209 results on '"Ong, Ken K"'
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2. Understanding the genetic complexity of puberty timing across the allele frequency spectrum
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Kentistou, Katherine A., Kaisinger, Lena R., Stankovic, Stasa, Vaudel, Marc, Mendes de Oliveira, Edson, Messina, Andrea, Walters, Robin G., Liu, Xiaoxi, Busch, Alexander S., Helgason, Hannes, Thompson, Deborah J., Santoni, Federico, Petricek, Konstantin M., Zouaghi, Yassine, Huang-Doran, Isabel, Gudbjartsson, Daniel F., Bratland, Eirik, Lin, Kuang, Gardner, Eugene J., Zhao, Yajie, Jia, Raina Y., Terao, Chikashi, Riggan, Marjorie J., Bolla, Manjeet K., Yazdanpanah, Mojgan, Yazdanpanah, Nahid, Bradfield, Jonathan P., Broer, Linda, Campbell, Archie, Chasman, Daniel I., Cousminer, Diana L., Franceschini, Nora, Franke, Lude H., Girotto, Giorgia, He, Chunyan, Järvelin, Marjo-Riitta, Joshi, Peter K., Kamatani, Yoichiro, Karlsson, Robert, Luan, Jian’an, Lunetta, Kathryn L., Mägi, Reedik, Mangino, Massimo, Medland, Sarah E., Meisinger, Christa, Noordam, Raymond, Nutile, Teresa, Concas, Maria Pina, Polašek, Ozren, Porcu, Eleonora, Ring, Susan M., Sala, Cinzia, Smith, Albert V., Tanaka, Toshiko, van der Most, Peter J., Vitart, Veronique, Wang, Carol A., Willemsen, Gonneke, Zygmunt, Marek, Ahearn, Thomas U., Andrulis, Irene L., Anton-Culver, Hoda, Antoniou, Antonis C., Auer, Paul L., Barnes, Catriona L. K., Beckmann, Matthias W., Berrington de Gonzalez, Amy, Bogdanova, Natalia V., Bojesen, Stig E., Brenner, Hermann, Buring, Julie E., Canzian, Federico, Chang-Claude, Jenny, Couch, Fergus J., Cox, Angela, Crisponi, Laura, Czene, Kamila, Daly, Mary B., Demerath, Ellen W., Dennis, Joe, Devilee, Peter, De Vivo, Immaculata, Dörk, Thilo, Dunning, Alison M., Dwek, Miriam, Eriksson, Johan G., Fasching, Peter A., Fernandez-Rhodes, Lindsay, Ferreli, Liana, Fletcher, Olivia, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A., González-Neira, Anna, Grallert, Harald, Guénel, Pascal, Haiman, Christopher A., Hall, Per, Hamann, Ute, Hakonarson, Hakon, Hart, Roger J., Hickey, Martha, Hooning, Maartje J., Hoppe, Reiner, Hopper, John L., Hottenga, Jouke-Jan, Hu, Frank B., Huebner, Hanna, Hunter, David J., Jernström, Helena, John, Esther M., Karasik, David, Khusnutdinova, Elza K., Kristensen, Vessela N., Lacey, James V., Lambrechts, Diether, Launer, Lenore J., Lind, Penelope A., Lindblom, Annika, Magnusson, Patrik K. E., Mannermaa, Arto, McCarthy, Mark I., Meitinger, Thomas, Menni, Cristina, Michailidou, Kyriaki, Millwood, Iona Y., Milne, Roger L., Montgomery, Grant W., Nevanlinna, Heli, Nolte, Ilja M., Nyholt, Dale R., Obi, Nadia, O’Brien, Katie M., Offit, Kenneth, Oldehinkel, Albertine J., Ostrowski, Sisse R., Palotie, Aarno, Pedersen, Ole B., Peters, Annette, Pianigiani, Giulia, Plaseska-Karanfilska, Dijana, Pouta, Anneli, Pozarickij, Alfred, Radice, Paolo, Rennert, Gad, Rosendaal, Frits R., Ruggiero, Daniela, Saloustros, Emmanouil, Sandler, Dale P., Schipf, Sabine, Schmidt, Carsten O., Schmidt, Marjanka K., Small, Kerrin, Spedicati, Beatrice, Stampfer, Meir, Stone, Jennifer, Tamimi, Rulla M., Teras, Lauren R., Tikkanen, Emmi, Turman, Constance, Vachon, Celine M., Wang, Qin, Winqvist, Robert, Wolk, Alicja, Zemel, Babette S., Zheng, Wei, van Dijk, Ko W., Alizadeh, Behrooz Z., Bandinelli, Stefania, Boerwinkle, Eric, Boomsma, Dorret I., Ciullo, Marina, Chenevix-Trench, Georgia, Cucca, Francesco, Esko, Tõnu, Gieger, Christian, Grant, Struan F. A., Gudnason, Vilmundur, Hayward, Caroline, Kolčić, Ivana, Kraft, Peter, Lawlor, Deborah A., Martin, Nicholas G., Nøhr, Ellen A., Pedersen, Nancy L., Pennell, Craig E., Ridker, Paul M., Robino, Antonietta, Snieder, Harold, Sovio, Ulla, Spector, Tim D., Stöckl, Doris, Sudlow, Cathie, Timpson, Nic J., Toniolo, Daniela, Uitterlinden, André, Ulivi, Sheila, Völzke, Henry, Wareham, Nicholas J., Widen, Elisabeth, Wilson, James F., Pharoah, Paul D. P., Li, Liming, Easton, Douglas F., Njølstad, Pål R., Sulem, Patrick, Murabito, Joanne M., Murray, Anna, Manousaki, Despoina, Juul, Anders, Erikstrup, Christian, Stefansson, Kari, Horikoshi, Momoko, Chen, Zhengming, Farooqi, I. Sadaf, Pitteloud, Nelly, Johansson, Stefan, Day, Felix R., Perry, John R. B., and Ong, Ken K.
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- 2024
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3. Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease
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Zhao, Yajie, Chukanova, Maria, Kentistou, Katherine A., Fairhurst-Hunter, Zammy, Siegert, Anna Maria, Jia, Raina Y., Dowsett, Georgina K. C., Gardner, Eugene J., Lawler, Katherine, Day, Felix R., Kaisinger, Lena R., Tung, Yi-Chun Loraine, Lam, Brian Yee Hong, Chen, Hsiao-Jou Cortina, Wang, Quanli, Berumen-Campos, Jaime, Kuri-Morales, Pablo, Tapia-Conyer, Roberto, Alegre-Diaz, Jesus, Barroso, Inês, Emberson, Jonathan, Torres, Jason M., Collins, Rory, Saleheen, Danish, Smith, Katherine R., Paul, Dirk S., Merkle, Florian, Farooqi, I. Sadaf, Wareham, Nick J., Petrovski, Slavé, O’Rahilly, Stephen, Ong, Ken K., Yeo, Giles S. H., and Perry, John R. B.
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- 2024
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4. Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum
- Author
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Kentistou, Katherine A., Kaisinger, Lena R., Stankovic, Stasa, Vaudel, Marc, Mendes de Oliveira, Edson, Messina, Andrea, Walters, Robin G., Liu, Xiaoxi, Busch, Alexander S., Helgason, Hannes, Thompson, Deborah J., Santoni, Federico, Petricek, Konstantin M., Zouaghi, Yassine, Huang-Doran, Isabel, Gudbjartsson, Daniel F., Bratland, Eirik, Lin, Kuang, Gardner, Eugene J., Zhao, Yajie, Jia, Raina Y., Terao, Chikashi, Riggan, Marjorie J., Bolla, Manjeet K., Yazdanpanah, Mojgan, Yazdanpanah, Nahid, Bradfield, Jonathan P., Broer, Linda, Campbell, Archie, Chasman, Daniel I., Cousminer, Diana L., Franceschini, Nora, Franke, Lude H., Girotto, Giorgia, He, Chunyan, Järvelin, Marjo-Riitta, Joshi, Peter K., Kamatani, Yoichiro, Karlsson, Robert, Luan, Jian’an, Lunetta, Kathryn L., Mägi, Reedik, Mangino, Massimo, Medland, Sarah E., Meisinger, Christa, Noordam, Raymond, Nutile, Teresa, Concas, Maria Pina, Polašek, Ozren, Porcu, Eleonora, Ring, Susan M., Sala, Cinzia, Smith, Albert V., Tanaka, Toshiko, van der Most, Peter J., Vitart, Veronique, Wang, Carol A., Willemsen, Gonneke, Zygmunt, Marek, Ahearn, Thomas U., Andrulis, Irene L., Anton-Culver, Hoda, Antoniou, Antonis C., Auer, Paul L., Barnes, Catriona L. K., Beckmann, Matthias W., Berrington de Gonzalez, Amy, Bogdanova, Natalia V., Bojesen, Stig E., Brenner, Hermann, Buring, Julie E., Canzian, Federico, Chang-Claude, Jenny, Couch, Fergus J., Cox, Angela, Crisponi, Laura, Czene, Kamila, Daly, Mary B., Demerath, Ellen W., Dennis, Joe, Devilee, Peter, De Vivo, Immaculata, Dörk, Thilo, Dunning, Alison M., Dwek, Miriam, Eriksson, Johan G., Fasching, Peter A., Fernandez-Rhodes, Lindsay, Ferreli, Liana, Fletcher, Olivia, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A., González-Neira, Anna, Grallert, Harald, Guénel, Pascal, Haiman, Christopher A., Hall, Per, Hamann, Ute, Hakonarson, Hakon, Hart, Roger J., Hickey, Martha, Hooning, Maartje J., Hoppe, Reiner, Hopper, John L., Hottenga, Jouke-Jan, Hu, Frank B., Huebner, Hanna, Hunter, David J., Jernström, Helena, John, Esther M., Karasik, David, Khusnutdinova, Elza K., Kristensen, Vessela N., Lacey, James V., Lambrechts, Diether, Launer, Lenore J., Lind, Penelope A., Lindblom, Annika, Magnusson, Patrik K. E., Mannermaa, Arto, McCarthy, Mark I., Meitinger, Thomas, Menni, Cristina, Michailidou, Kyriaki, Millwood, Iona Y., Milne, Roger L., Montgomery, Grant W., Nevanlinna, Heli, Nolte, Ilja M., Nyholt, Dale R., Obi, Nadia, O’Brien, Katie M., Offit, Kenneth, Oldehinkel, Albertine J., Ostrowski, Sisse R., Palotie, Aarno, Pedersen, Ole B., Peters, Annette, Pianigiani, Giulia, Plaseska-Karanfilska, Dijana, Pouta, Anneli, Pozarickij, Alfred, Radice, Paolo, Rennert, Gad, Rosendaal, Frits R., Ruggiero, Daniela, Saloustros, Emmanouil, Sandler, Dale P., Schipf, Sabine, Schmidt, Carsten O., Schmidt, Marjanka K., Small, Kerrin, Spedicati, Beatrice, Stampfer, Meir, Stone, Jennifer, Tamimi, Rulla M., Teras, Lauren R., Tikkanen, Emmi, Turman, Constance, Vachon, Celine M., Wang, Qin, Winqvist, Robert, Wolk, Alicja, Zemel, Babette S., Zheng, Wei, van Dijk, Ko W., Alizadeh, Behrooz Z., Bandinelli, Stefania, Boerwinkle, Eric, Boomsma, Dorret I., Ciullo, Marina, Chenevix-Trench, Georgia, Cucca, Francesco, Esko, Tõnu, Gieger, Christian, Grant, Struan F. A., Gudnason, Vilmundur, Hayward, Caroline, Kolčić, Ivana, Kraft, Peter, Lawlor, Deborah A., Martin, Nicholas G., Nøhr, Ellen A., Pedersen, Nancy L., Pennell, Craig E., Ridker, Paul M., Robino, Antonietta, Snieder, Harold, Sovio, Ulla, Spector, Tim D., Stöckl, Doris, Sudlow, Cathie, Timpson, Nic J., Toniolo, Daniela, Uitterlinden, André, Ulivi, Sheila, Völzke, Henry, Wareham, Nicholas J., Widen, Elisabeth, Wilson, James F., Pharoah, Paul D. P., Li, Liming, Easton, Douglas F., Njølstad, Pål R., Sulem, Patrick, Murabito, Joanne M., Murray, Anna, Manousaki, Despoina, Juul, Anders, Erikstrup, Christian, Stefansson, Kari, Horikoshi, Momoko, Chen, Zhengming, Farooqi, I. Sadaf, Pitteloud, Nelly, Johansson, Stefan, Day, Felix R., Perry, John R. B., and Ong, Ken K.
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- 2024
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5. Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
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Anderson, Greg M., Hill, Jennifer W., Kaiser, Ursula B., Navarro, Victor M., Ong, Ken K., Perry, John R. B., Prevot, Vincent, Tena-Sempere, Manuel, and Elias, Carol F.
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- 2024
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6. Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries
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Li, Chunxiao, Bishop, Tom R P, Imamura, Fumiaki, Sharp, Stephen J, Pearce, Matthew, Brage, Soren, Ong, Ken K, Ahsan, Habibul, Bes-Rastrollo, Maira, Beulens, Joline W J, den Braver, Nicole, Byberg, Liisa, Canhada, Scheine, Chen, Zhengming, Chung, Hsin-Fang, Cortés-Valencia, Adrian, Djousse, Luc, Drouin-Chartier, Jean-Philippe, Du, Huaidong, Du, Shufa, Duncan, Bruce B, Gaziano, J Michael, Gordon-Larsen, Penny, Goto, Atsushi, Haghighatdoost, Fahimeh, Härkänen, Tommi, Hashemian, Maryam, Hu, Frank B, Ittermann, Till, Järvinen, Ritva, Kakkoura, Maria G, Neelakantan, Nithya, Knekt, Paul, Lajous, Martin, Li, Yanping, Magliano, Dianna J, Malekzadeh, Reza, Le Marchand, Loic, Marques-Vidal, Pedro, Martinez-Gonzalez, Miguel A, Maskarinec, Gertraud, Mishra, Gita D, Mohammadifard, Noushin, O'Donoghue, Gráinne, O'Gorman, Donal, Popkin, Barry, Poustchi, Hossein, Sarrafzadegan, Nizal, Sawada, Norie, Schmidt, Maria Inês, Shaw, Jonathan E, Soedamah-Muthu, Sabita, Stern, Dalia, Tong, Lin, van Dam, Rob M, Völzke, Henry, Willett, Walter C, Wolk, Alicja, Yu, Canqing, Forouhi, Nita G, and Wareham, Nicholas J
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- 2024
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7. Loss of transient receptor potential channel 5 causes obesity and postpartum depression
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Li, Yongxiang, Cacciottolo, Tessa M., Yin, Na, He, Yang, Liu, Hesong, Liu, Hailan, Yang, Yuxue, Henning, Elana, Keogh, Julia M., Lawler, Katherine, Mendes de Oliveira, Edson, Gardner, Eugene J., Kentistou, Katherine A., Laouris, Panayiotis, Bounds, Rebecca, Ong, Ken K., Perry, John R.B., Barroso, Inês, Tu, Longlong, Bean, Jonathan C., Yu, Meng, Conde, Kristine M., Wang, Mengjie, Ginnard, Olivia, Fang, Xing, Tong, Lydia, Han, Junying, Darwich, Tia, Williams, Kevin W., Yang, Yongjie, Wang, Chunmei, Joss, Shelagh, Firth, Helen V., Xu, Yong, and Farooqi, I. Sadaf
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- 2024
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8. Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency
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Shekari, Saleh, Stankovic, Stasa, Gardner, Eugene J., Hawkes, Gareth, Kentistou, Katherine A., Beaumont, Robin N., Mörseburg, Alexander, Wood, Andrew R., Prague, Julia K., Mishra, Gita D., Day, Felix R., Baptista, Julia, Wright, Caroline F., Weedon, Michael N., Hoffmann, Eva R., Ruth, Katherine S., Ong, Ken K., Perry, John R. B., and Murray, Anna
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- 2023
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9. Associations of appetitive traits with growth velocities from infancy to childhood
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Olwi, Duaa Ibrahim, Day, Felix R., Cheng, Tuck Seng, Olga, Laurentya, Petry, Clive J., Hughes, Ieuan A., Smith, Andrea D., and Ong, Ken K.
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- 2023
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10. Genetic impacts on DNA methylation help elucidate regulatory genomic processes
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Villicaña, Sergio, Castillo-Fernandez, Juan, Hannon, Eilis, Christiansen, Colette, Tsai, Pei-Chien, Maddock, Jane, Kuh, Diana, Suderman, Matthew, Power, Christine, Relton, Caroline, Ploubidis, George, Wong, Andrew, Hardy, Rebecca, Goodman, Alissa, Ong, Ken K., and Bell, Jordana T.
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- 2023
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11. Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
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Mathieson, Iain, Day, Felix R., Barban, Nicola, Tropf, Felix C., Brazel, David M., Vaez, Ahmad, van Zuydam, Natalie, Bitarello, Bárbara D., Gardner, Eugene J., Akimova, Evelina T., Azad, Ajuna, Bergmann, Sven, Bielak, Lawrence F., Boomsma, Dorret I., Bosak, Kristina, Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey Smith, George, Davies, Gail, Deary, Ian J., Esko, Tõnu, Faul, Jessica D., Franco, Oscar, Ganna, Andrea, Gaskins, Audrey J., Gelemanovic, Andrea, de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Gopinath, Bamini, Grabe, Hans Jörgen, Gunderson, Erica P., Hayward, Caroline, He, Chunyan, van Heemst, Diana, Hill, W. David, Hoffmann, Eva R., Homuth, Georg, Hottenga, Jouke Jan, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M. Arfan, Jansen, Rick, Johannesson, Magnus, Kamali, Zoha, Kardia, Sharon L. R., Kavousi, Maryam, Kifley, Annette, Kiiskinen, Tuomo, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Liew, Gerald, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, Medland, Sarah E., Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Milani, Lili, Missmer, Stacey A., Mitchell, Paul, Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, van der Most, Peter J., de Mutsert, Renée, Nauck, Matthias, Nolte, Ilja M., Noordam, Raymond, Penninx, Brenda W. J. H., Peters, Annette, Peyser, Patricia A., Polašek, Ozren, Power, Chris, Pribisalic, Ajka, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Shukla, Vallari, Smith, Jennifer A., Stankovic, Stasa, Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Swertz, Morris A., Teumer, Alexander, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Uitterlinden, André G., Waldenberger, Melanie, Wareham, Nicholas J., Weir, David R., Willemsen, Gonneke, Zhao, Jing Hau, Zhao, Wei, Zhao, Yajie, Snieder, Harold, den Hoed, Marcel, Ong, Ken K., Mills, Melinda C., and Perry, John R. B.
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- 2023
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12. Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity
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Kaisinger, Lena R., Kentistou, Katherine A., Stankovic, Stasa, Gardner, Eugene J., Day, Felix R., Zhao, Yajie, Mörseburg, Alexander, Carnie, Christopher J., Zagnoli-Vieira, Guido, Puddu, Fabio, Jackson, Stephen P., O’Rahilly, Stephen, Farooqi, I. Sadaf, Dearden, Laura, Pantaleão, Lucas C., Ozanne, Susan E., Ong, Ken K., and Perry, John R.B.
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- 2023
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13. Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study
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Canton, Ana P M, Tinano, Flávia R, Guasti, Leonardo, Montenegro, Luciana R, Ryan, Fiona, Shears, Deborah, de Melo, Maria Edna, Gomes, Larissa G, Piana, Mariana P, Brauner, Raja, Espino-Aguilar, Rafael, Escribano-Muñoz, Arancha, Paganoni, Alyssa, Read, Jordan E, Korbonits, Márta, Seraphim, Carlos E, Costa, Silvia S, Krepischi, Ana Cristina, Jorge, Alexander A L, David, Alessia, Kaisinger, Lena R, Ong, Ken K, Perry, John R B, Abreu, Ana Paula, Kaiser, Ursula B, Argente, Jesús, Mendonca, Berenice B, Brito, Vinicius N, Howard, Sasha R, and Latronico, Ana Claudia
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- 2023
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14. Associations between abdominal adiposity, body size and objectively measured physical activity in infants from Soweto, South Africa
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Prioreschi, Alessandra, Ong, Ken K, Rolfe, Emanuella De Lucia, Westgate, Kate, Micklesfield, Lisa K, and Brage, Soren
- Subjects
Soweto, South Africa -- Health aspects ,Exercise -- Health aspects ,Body size -- Health aspects ,Adipose tissues -- Health aspects ,Infants -- Physiological aspects -- Health aspects ,Pediatric research ,Health care industry - Abstract
Objectives: Considering the importance of the early life period, in conjunction with the increasing prevalence of adiposity and insufficient physical activity already evident in early childhood, this study aimed to determine associations between abdominal adiposity, body size, and objectively measured physical activity in infancy. Methods: Infants (n = 138, aged 3-24 months) from Soweto, South Africa were recruited to this cross-sectional study. Visceral (VAT) and subcutaneous abdominal fat (SAT) were measured using ultrasound. Physical activity was assessed using accelerometry and analysed at the hourly level. Multilevel linear regression analyses were run with body composition exposures adjusted for age, sex, and length; models with VAT and SAT were also adjusted for total abdominal fat. Results: Mean (SD) age was 11.8 (7.6) months; 86% were normal weight, 7% were underweight and 7% overweight. In linear models, no body composition variable was significantly associated with physical activity. Physical activity was higher with each increasing length tertile (ANOVA p < 0.01); with a mean(95%CI) 29(60-60)mg in the lowest tertile, 39(71-71)mg in the middle tertile, and 50(81-82)mg in the highest tertile. Infants with normal weight had higher mean(95%CI) physical activity (40(70-80)mg) than underweight (34(73-85)mg, p = 0.01) or overweight infants (31(63-78)mg, ANOVA p < 0.01). When also adjusting for total abdominal fat, infants in the lowest SAT tertile had higher physical activity than those in the middle or highest SAT tertiles (p < 0.01). Conclusions These findings lend support for higher physical activity as a marker of healthy growth in the first two years of life., Author(s): Alessandra Prioreschi [sup.1] , Ken K Ong [sup.1] [sup.2] , Emanuella De Lucia Rolfe [sup.2] , Kate Westgate [sup.2] , Lisa K Micklesfield [sup.1] , Soren Brage [sup.2] Author [...]
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- 2022
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15. Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food
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Dearden, Laura, primary, Furigo, Isadora C., additional, Pantaleão, Lucas C., additional, Wong, L W. P., additional, Fernandez-Twinn, Denise S., additional, de Almeida-Faria, Juliana, additional, Kentistou, Katherine A., additional, Carreira, Maria V., additional, Bidault, Guillaume, additional, Vidal-Puig, Antonio, additional, Ong, Ken K., additional, Perry, John R. B., additional, Donato, Jose, additional, and Ozanne, Susan E., additional
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- 2024
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16. Population scale whole genome sequencing provides novel insights into cardiometabolic health
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Zhao, Yajie, primary, Lockhart, Sam, additional, Liu, Jimmy, additional, Li, Xihao, additional, Cortes, Adrian, additional, Hua, Xing, additional, Gardner, Eugene J., additional, Kentistou, Katherine A., additional, Lo, Yancy, additional, Davitte, Jonathan, additional, Savage, David B., additional, Buser-Doepner, Carolyn, additional, Ong, Ken K., additional, Zhang, Haoyu, additional, Scott, Robert, additional, O'Rahilly, Stephen, additional, and Perry, John R.B., additional
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- 2024
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17. Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts
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Fraszczyk, Eliza, Spijkerman, Annemieke M. W., Zhang, Yan, Brandmaier, Stefan, Day, Felix R., Zhou, Li, Wackers, Paul, Dollé, Martijn E. T., Bloks, Vincent W., Gào, Xīn, Gieger, Christian, Kooner, Jaspal, Kriebel, Jennifer, Picavet, H. Susan J., Rathmann, Wolfgang, Schöttker, Ben, Loh, Marie, Verschuren, W. M. Monique, van Vliet-Ostaptchouk, Jana V., Wareham, Nicholas J., Chambers, John C., Ong, Ken K., Grallert, Harald, Brenner, Hermann, Luijten, Mirjam, and Snieder, Harold
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- 2022
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18. Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes
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Gardner, Eugene J., Kentistou, Katherine A., Stankovic, Stasa, Lockhart, Samuel, Wheeler, Eleanor, Day, Felix R., Kerrison, Nicola D., Wareham, Nicholas J., Langenberg, Claudia, O'Rahilly, Stephen, Ong, Ken K., and Perry, John R.B.
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- 2022
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19. Trends Toward Earlier Puberty Timing in Girls and Its Likely Mechanisms
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Cheng, Tuck Seng, Ong, Ken K., and Biro, Frank M.
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- 2022
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20. Adverse Effects of Early Puberty Timing in Girls and Potential Solutions
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Cheng, Tuck Seng, Ong, Ken K., and Biro, Frank M.
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- 2022
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21. Distinct infant feeding type-specific plasma metabolites at age 3 months associate with body composition at 2 years
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van Beijsterveldt, Inge A.L.P., Myers, Pernille Neve, Snowden, Stuart G., Ong, Ken K., Brix, Susanne, Hokken-Koelega, Anita C.S., and Koulman, Albert
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- 2022
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22. Longitudinal associations between prepubertal childhood total energy and macronutrient intakes and subsequent puberty timing in UK boys and girls
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Cheng, Tuck Seng, Sharp, Stephen J., Brage, Soren, Emmett, Pauline M., Forouhi, Nita G., and Ong, Ken K.
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- 2022
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23. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
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Wielscher, Matthias, Mandaviya, Pooja R., Kuehnel, Brigitte, Joehanes, Roby, Mustafa, Rima, Robinson, Oliver, Zhang, Yan, Bodinier, Barbara, Walton, Esther, Mishra, Pashupati P., Schlosser, Pascal, Wilson, Rory, Tsai, Pei-Chien, Palaniswamy, Saranya, Marioni, Riccardo E., Fiorito, Giovanni, Cugliari, Giovanni, Karhunen, Ville, Ghanbari, Mohsen, Psaty, Bruce M., Loh, Marie, Bis, Joshua C., Lehne, Benjamin, Sotoodehnia, Nona, Deary, Ian J., Chadeau-Hyam, Marc, Brody, Jennifer A., Cardona, Alexia, Selvin, Elizabeth, Smith, Alicia K., Miller, Andrew H., Torres, Mylin A., Marouli, Eirini, Gào, Xin, van Meurs, Joyce B. J., Graf-Schindler, Johanna, Rathmann, Wolfgang, Koenig, Wolfgang, Peters, Annette, Weninger, Wolfgang, Farlik, Matthias, Zhang, Tao, Chen, Wei, Xia, Yujing, Teumer, Alexander, Nauck, Matthias, Grabe, Hans J., Doerr, Macus, Lehtimäki, Terho, Guan, Weihua, Milani, Lili, Tanaka, Toshiko, Fisher, Krista, Waite, Lindsay L., Kasela, Silva, Vineis, Paolo, Verweij, Niek, van der Harst, Pim, Iacoviello, Licia, Sacerdote, Carlotta, Panico, Salvatore, Krogh, Vittorio, Tumino, Rosario, Tzala, Evangelia, Matullo, Giuseppe, Hurme, Mikko A., Raitakari, Olli T., Colicino, Elena, Baccarelli, Andrea A., Kähönen, Mika, Herzig, Karl-Heinz, Li, Shengxu, Conneely, Karen N., Kooner, Jaspal S., Köttgen, Anna, Heijmans, Bastiaan T., Deloukas, Panos, Relton, Caroline, Ong, Ken K., Bell, Jordana T., Boerwinkle, Eric, Elliott, Paul, Brenner, Hermann, Beekman, Marian, Levy, Daniel, Waldenberger, Melanie, Chambers, John C., Dehghan, Abbas, and Järvelin, Marjo-Riitta
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- 2022
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24. Increased basal insulin sensitivity in late pregnancy in women carrying a male fetus: a cohort study
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Petry, Clive J., Hughes, Ieuan A., and Ong, Ken K.
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- 2022
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25. Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
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Mills, Melinda C., Tropf, Felix C., Brazel, David M., van Zuydam, Natalie, Vaez, Ahmad, Pers, Tune H., Snieder, Harold, Perry, John R. B., Ong, Ken K., den Hoed, Marcel, Barban, Nicola, and Day, Felix R.
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- 2021
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26. Meta-analysis of epigenome-wide association studies of carotid intima-media thickness
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Portilla-Fernández, Eliana, Hwang, Shih-Jen, Wilson, Rory, Maddock, Jane, Hill, W. David, Teumer, Alexander, Mishra, Pashupati P., Brody, Jennifer A., Joehanes, Roby, Ligthart, Symen, Ghanbari, Mohsen, Kavousi, Maryam, Roks, Anton J. M., Danser, A. H. Jan, Levy, Daniel, Peters, Annette, Ghasemi, Sahar, Schminke, Ulf, Dörr, Marcus, Grabe, Hans J., Lehtimäki, Terho, Kähönen, Mika, Hurme, Mikko A., Bartz, Traci M., Sotoodehnia, Nona, Bis, Joshua C., Thiery, Joachim, Koenig, Wolfgang, Ong, Ken K., Bell, Jordana T., Meisinger, Christine, Wardlaw, Joanna M., Starr, John M., Seissler, Jochen, Then, Cornelia, Rathmann, Wolfgang, Ikram, M. Arfan, Psaty, Bruce M., Raitakari, Olli T., Völzke, Henry, Deary, Ian J., Wong, Andrew, Waldenberger, Melanie, O’Donnell, Christopher J., and Dehghan, Abbas
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- 2021
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27. Mendelian randomization identifies circulating proteins as biomarkers for age at menarche and age at natural menopause
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Yazdanpanah, Nahid, primary, Jumentier, Basile, additional, Yazdanpanah, Mojgan, additional, Ong, Ken K., additional, Perry, John R. B., additional, and Manousaki, Despoina, additional
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- 2024
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28. Penetrance of Pathogenic Genetic Variants Associated With Premature Ovarian Insufficiency
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Shekari, Saleh, primary, Stankovic, Stasa, additional, Gardner, Eugene J., additional, Hawkes, Gareth, additional, Kentistou, Katherine A., additional, Beaumont, Robin N., additional, Mörseburg, Alexander, additional, Wood, Andrew R., additional, Prague, Julia K., additional, Mishra, Gita D., additional, Day, Felix R., additional, Baptista, Julia, additional, Wright, Caroline F., additional, Weedon, Michael N., additional, Hoffmann, Eva R., additional, Ruth, Katherine S., additional, Ong, Ken K., additional, Perry, John R. B., additional, and Murray, Anna, additional
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- 2024
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29. Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity
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Mbarek, Hamdi, primary, Gordon, Scott D, additional, Duffy, David L, additional, Hubers, Nikki, additional, Mortlock, Sally, additional, Beck, Jeffrey J, additional, Hottenga, Jouke-Jan, additional, Pool, René, additional, Dolan, Conor V, additional, Actkins, Ky’Era V, additional, Gerring, Zachary F, additional, Van Dongen, Jenny, additional, Ehli, Erik A, additional, Iacono, William G, additional, Mcgue, Matt, additional, Chasman, Daniel I, additional, Gallagher, C Scott, additional, Schilit, Samantha L P, additional, Morton, Cynthia C, additional, Paré, Guillaume, additional, Willemsen, Gonneke, additional, Whiteman, David C, additional, Olsen, Catherine M, additional, Derom, Catherine, additional, Vlietinck, Robert, additional, Gudbjartsson, Daniel, additional, Cannon-Albright, Lisa, additional, Krapohl, Eva, additional, Plomin, Robert, additional, Magnusson, Patrik K E, additional, Pedersen, Nancy L, additional, Hysi, Pirro, additional, Mangino, Massimo, additional, Spector, Timothy D, additional, Palviainen, Teemu, additional, Milaneschi, Yuri, additional, Penninnx, Brenda W, additional, Campos, Adrian I, additional, Ong, Ken K, additional, Perry, John R B, additional, Lambalk, Cornelis B, additional, Kaprio, Jaakko, additional, Ólafsson, Ísleifur, additional, Duroure, Karine, additional, Revenu, Céline, additional, Rentería, Miguel E, additional, Yengo, Loic, additional, Davis, Lea, additional, Derks, Eske M, additional, Medland, Sarah E, additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Del Bene, Filippo, additional, Reversade, Bruno, additional, Montgomery, Grant W, additional, Boomsma, Dorret I, additional, and Martin, Nicholas G, additional
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- 2023
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30. High but decreasing prevalence of overweight in preschool children: encouragement for further action
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Maessen, Sarah E, primary, Nichols, Melanie, additional, Cutfield, Wayne, additional, Norris, Shane A, additional, Beger, Christoph, additional, and Ong, Ken K, additional
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- 2023
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31. An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults
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Weir, Elizabeth, Allison, Carrie, Ong, Ken K., and Baron-Cohen, Simon
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- 2021
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32. Folic acid supplementation during pregnancy and associations with offspring size at birth and adiposity: a cohort study
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Petry, Clive J., Ong, Ken K., Hughes, Ieuan A., and Dunger, David B.
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- 2021
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33. SMIM1 absence is associated with reduced energy expenditure and excess weight
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Banasik, Karina, Bay, Jakob, Boldsen, Jens Kjærgaard, Brodersen, Thorsten, Brunak, Søren, Burgdorf, Kristoffer, Chalmer, Mona Ameri, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Hindhede, Lotte, Hjalgrim, Henrik, Jacobsen, Rikke Louise, Jemec, Gregor, Jensen, Bitten Aagaard, Kaspersen, Katrine, Kjerulff, Bertram Dalskov, Kogelman, Lisette, Hørup Larsen, Margit Anita, Louloudis, Ioannis, Lundgaard, Agnete, Susan, Mikkelsen, Christina, Nissen, Ioanna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Henriksen, Alexander Pil, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Stefansson, Kari, Stefánsson, Hreinn, Sørensen, Erik, þorsteinsdóttir, Unnur, Thørner, Lise Wegner, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian’an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Katie Chan, Kei Hang, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Loz, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V.R., Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P., Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Southam, Lorraine, Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J.L., Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J.C., Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M. Arfan, Johnson, W. Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R.H.J., Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, Van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Goncalo R., Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Ida Chen, Yii-Der, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, Janaka de Silva, H., Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J. Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L.R., Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J.F., Magnusson, Patrik K.E., Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N.A., Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P. Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I.A., Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E. Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G.M., Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C.J., Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., Barroso, Inês, Stefanucci, Luca, Moslemi, Camous, Tomé, Ana R., Virtue, Samuel, Bidault, Guillaume, Gleadall, Nicholas S., Watson, Laura P.E., Kwa, Jing E., Burden, Frances, Farrow, Samantha, Võsa, Urmo, Burling, Keith, Walker, Lindsay, Ord, John, Barker, Peter, Warner, James, Frary, Amy, Renhstrom, Karola, Ashford, Sofie E., Piper, Jo, Biggs, Gail, Erber, Wendy N., Hoffman, Gary J., Schoenmakers, Nadia, Rieneck, Klaus, Dziegiel, Morten H., Azzu, Vian, Vacca, Michele, Aparicio, Hugo Javier, Hui, Qin, Cho, Kelly, Sun, Yan V., Wilson, Peter W., Bayraktar, Omer A., Vidal-Puig, Antonio, Ostrowski, Sisse R., Astle, William J., Olsson, Martin L., Storry, Jill R., Pedersen, Ole B., Ouwehand, Willem H., Chatterjee, Krishna, Vuckovic, Dragana, and Frontini, Mattia
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- 2024
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34. Protein-truncating variants in BSNare associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease
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Zhao, Yajie, Chukanova, Maria, Kentistou, Katherine A., Fairhurst-Hunter, Zammy, Siegert, Anna Maria, Jia, Raina Y., Dowsett, Georgina K. C., Gardner, Eugene J., Lawler, Katherine, Day, Felix R., Kaisinger, Lena R., Tung, Yi-Chun Loraine, Lam, Brian Yee Hong, Chen, Hsiao-Jou Cortina, Wang, Quanli, Berumen-Campos, Jaime, Kuri-Morales, Pablo, Tapia-Conyer, Roberto, Alegre-Diaz, Jesus, Barroso, Inês, Emberson, Jonathan, Torres, Jason M., Collins, Rory, Saleheen, Danish, Smith, Katherine R., Paul, Dirk S., Merkle, Florian, Farooqi, I. Sadaf, Wareham, Nick J., Petrovski, Slavé, O’Rahilly, Stephen, Ong, Ken K., Yeo, Giles S. H., and Perry, John R. B.
- Abstract
Obesity is a major risk factor for many common diseases and has a substantial heritable component. To identify new genetic determinants, we performed exome-sequence analyses for adult body mass index (BMI) in up to 587,027 individuals. We identified rare loss-of-function variants in two genes (BSNand APBA1) with effects substantially larger than those of well-established obesity genes such as MC4R. In contrast to most other obesity-related genes, rare variants in BSNand APBA1were not associated with normal variation in childhood adiposity. Furthermore, BSNprotein-truncating variants (PTVs) magnified the influence of common genetic variants associated with BMI, with a common variant polygenic score exhibiting an effect twice as large in BSNPTV carriers than in noncarriers. Finally, we explored the plasma proteomic signatures of BSNPTV carriers as well as the functional consequences of BSNdeletion in human induced pluripotent stem cell-derived hypothalamic neurons. Collectively, our findings implicate degenerative processes in synaptic function in the etiology of adult-onset obesity.
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- 2024
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35. Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty
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Duckett, Katie, Williamson, Alice, Kincaid, John WR, Rainbow, Kara, Corbin, Laura J, Martin, Hilary C, Eberhardt, Ruth Y, Huang, Qin Qin, Hurles, Matthew E, He, Wen, Brauner, Raja, Delaney, Angela, Dunkel, Leo, Grinspon, Romina P, Hall, Janet E, Hirschhorn, Joel N, Howard, Sasha R, Latronico, Ana C, Jorge, Alexander AL, McElreavey, Ken, Mericq, Verónica, Merino, Paulina M, Palmert, Mark R, Plummer, Lacey, Rey, Rodolfo A, Rezende, Raíssa C, Seminara, Stephanie B, Salnikov, Kathryn, Banerjee, Indraneel, Lam, Brian YH, Perry, John RB, Timpson, Nicholas J, Clayton, Peter, Chan, Yee-Ming, Ong, Ken K, O'Rahilly, Stephen, Duckett, Katie [0000-0002-0222-1689], Williamson, Alice [0000-0002-7599-9301], Kincaid, John WR [0000-0003-0660-9813], Rainbow, Kara [0000-0002-8089-0693], Corbin, Laura J [0000-0002-4032-9500], Martin, Hilary C [0000-0002-4454-9084], Eberhardt, Ruth Y [0000-0001-6152-1369], Huang, Qin Qin [0000-0003-3073-717X], Hurles, Matthew E [0000-0002-2333-7015], Brauner, Raja [0000-0002-4456-4508], Delaney, Angela [0000-0002-0632-6365], Grinspon, Romina P [0000-0002-6291-1518], Hall, Janet E [0000-0003-4644-3061], Hirschhorn, Joel N [0000-0002-1650-7901], Palmert, Mark R [0000-0002-4096-0685], Lam, Brian YH [0000-0002-3638-9025], Timpson, Nicholas J [0000-0002-7141-9189], Clayton, Peter [0000-0003-1225-4537], Chan, Yee-Ming [0000-0003-0554-8502], Ong, Ken K [0000-0003-4689-7530], O'Rahilly, Stephen [0000-0003-2199-4449], and Apollo - University of Cambridge Repository
- Subjects
UK Biobank ,constitutional delay ,MC3R ,ALSPAC ,delayed puberty - Abstract
ContextThe melanocortin 3 receptor (MC3R) has recently emerged as a critical regulator of pubertal timing, linear growth and the acquisition of lean mass in humans and mice. In population-based studies, heterozygous carriers of deleterious variants in MC3R report a later onset of puberty than non-carriers. However, the frequency of such variants in patients who present with clinical disorders of pubertal development is currently unknown.ObjectiveTo determine whether deleterious MC3R variants are more frequently found in patients clinically presenting with constitutional delay of growth and puberty (CDGP) or normosmic idiopathic hypogonadotropic hypogonadism (nIHH).Design, Setting and ParticipantsWe examined the sequence of MC3R in 362 adolescents with a clinical diagnosis of CDGP and 657 patients with nIHH, experimentally characterised the signalling properties of all non-synonymous variants found and compared their frequency to that in 5774 controls from a population-based cohort. Additionally, we established the relative frequency of predicted deleterious variants in individuals with self-reported delayed vs normally timed menarche/voice breaking in the UK Biobank cohort.ResultsMC3R loss-of-function variants were infrequent but overrepresented in patients with CDGP (8/362 (2.2%), OR = 4.17, p = 0.001). There was no strong evidence of overrepresentation in patients with nIHH (4/657 (0.6%), OR = 1.15, p = 0.779). In 246,328 women from UK Biobank, predicted deleterious variants were more frequently found in those self-reporting delayed (≥16 years) vs normal age at menarche (OR = 1.66, p = 3.90E-07).ConclusionsWe have found evidence that functionally damaging variants in MC3R are overrepresented in individuals with CDGP but are not a common cause of this phenotype.
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- 2023
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36. Leptin and IGF-1 in infancy are associated with variants in DHCR7 and CYP2R1 that relate with type 1 diabetes and 25OHD
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Eleftheriou, Antigoni, Ong, Ken K, Hughes, Ieuan A, Petry, Clive J, Eleftheriou, Antigoni [0000-0003-1374-719X], Ong, Ken K [0000-0003-4689-7530], Hughes, Ieuan A [0000-0002-8787-1575], Petry, Clive J [0000-0002-6642-9825], and Apollo - University of Cambridge Repository
- Subjects
type 1 diabetes ,IGF-1 ,vitamin D ,early growth ,leptin - Abstract
CONTEXT: Vitamin D has been variably implicated in risk of developing type 1 diabetes based on cohorts of at-risk individuals. Emergent type 1 diabetes in childhood is putatively preceded by altered growth. OBJECTIVE: We explored whether polymorphisms in vitamin D metabolism genes modify risk of type 1 diabetes via effects on growth in a prospective, population-based cohort of infants. DESIGN, SETTING AND PARTICIPANTS: The Cambridge Baby Growth Study enrolled newborns from Cambridgeshire, UK, for follow-up in infancy. In 612 infants, we genotyped single nucleotide polymorphisms in vitamin D metabolism genes that relate with type 1 diabetes: rs10741657 and rs12794714 in CYP2R1, rs12785878 in DHCR7, and rs10877012 in CYP27B1. Multivariate linear regression analyses tested associations between genotypes and anthropometric indices (weight, length, and skinfold thickness) or growth-related hormones (C-peptide, IGF-1, and leptin) in infancy. RESULTS: Birth weight showed borderline associations with the diabetes risk-increasing alleles in CYP2R1, rs10741657 (β=-0.11, P=0.02) and rs12794714 (β=-0.09, P=0.04). The risk-increasing allele rs12794714 was also associated with higher IGF-1 levels at age 24 months (β=0.30, P=0.01). At age 3 months, the risk-increasing allele rs12785878 in DHCR7, known to negatively associate with 25OHD levels, showed a positive association with leptin levels (β=0.23, P=0.009), which was pronounced in girls (P=0.004) vs. boys (P=0.7). CONCLUSIONS: The vitamin D metabolism genes DHCR7 and CYP2R1 might influence infancy leptin and IGF-1 levels respectively. These findings open the possibility for a developmental role of vitamin D that is mediated by growth-related hormones with implications for the onset of type 1 diabetes autoimmunity.
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- 2023
37. Butyrate in Human Milk : Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth
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Olga, Laurentya, Van Diepen, Janna A, Chichlowski, Maciej, Petry, Clive J, Vervoort, Jacques, Dunger, David B, Kortman, Guus AM, Gross, Gabriele, Ong, Ken K, Olga, Laurentya [0000-0002-3562-0598], Petry, Clive J [0000-0002-6642-9825], Kortman, Guus AM [0000-0002-8076-0661], Ong, Ken K [0000-0003-4689-7530], Apollo - University of Cambridge Repository, and Kortman, Guus A M [0000-0002-8076-0661]
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infant growth ,Nutrition and Dietetics ,Milk, Human ,human milk microbiota ,Microbiota ,infant weight gain ,Infant ,Weight Gain ,Butyrates ,Breast Feeding ,infant adiposity ,butyrate intake ,Humans ,Female ,Prospective Studies ,Host-Microbe Interactomics ,human milk intake volume ,human milk butyrate ,Food Science - Abstract
Peer reviewed: True, Funder: Reckitt/Mead Johnson Nutrition, Funder: National Institute for Health Research/Wellcome Trust Clinical Research Facility at Cambridge University Hospitals-NHS Foundation Trust, Funder: NIHR Cambridge Comprehensive Biomedical Research Centre, Butyrate in human milk (HM) has been suggested to reduce excessive weight and adipo-sity gains during infancy. However, HM butyrate's origins, determinants, and its influencing mechanism on weight gain are not completely understood. These were studied in the prospective longitudinal Cambridge Baby Growth and Breastfeeding Study (CBGS-BF), in which infants (n = 59) were exclusively breastfed for at least 6 weeks. Infant growth (birth, 2 weeks, 6 weeks, 3 months, 6 months, and 12 months) and HM butyrate concentrations (2 weeks, 6 weeks, 3 months, and 6 months) were measured. At age 6 weeks, HM intake volume was measured by deuterium-labelled water technique and HM microbiota by 16S sequencing. Cross-sectionally at 6 weeks, HM butyrate was associated with HM microbiota composition (p = 0.036) although no association with the abundance of typical butyrate producers was detected. In longitudinal analyses across all time points, HM butyrate concentrations were overall negatively associated with infant weight and adiposity, and associations were stronger at younger infant ages. HM butyrate concentration was also inversely correlated with HM intake volume, supporting a possible mechanism whereby butyrate might reduce infant growth via appetite regulation and modulation of HM intake.
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- 2023
38. Genome-wide analysis of promoter contacts identifies novel regulators of late-stage adipogenesis
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Sandovici, Ionel, primary, Mifsud, Borbala, additional, Emery, Amy, additional, Gulati, Pawan, additional, Kentistou, Katherine A., additional, Banu, Ayesha, additional, Campbell, Niamh, additional, Hardwick, Bryn S., additional, Crooks, Alex T., additional, Fernandez-Twinn, Denise S., additional, Mennitti, Lais V., additional, Srour, Luma, additional, Awad, Sherine, additional, Chiarugi, Davide, additional, Hamilton, Russell S., additional, Wingett, Steven W., additional, Fraser, Peter, additional, Ong, Ken K., additional, Schoenfelder, Stefan, additional, Mohammad, Farhan, additional, O’Rahilly, Stephen, additional, Perry, John R.B., additional, Venkitaraman, Ashok R., additional, Ozanne, Susan E., additional, and Constância, Miguel, additional
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- 2023
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39. Prevalence of Deleterious Variants in MC3R in Patients With Constitutional Delay of Growth and Puberty
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Duckett, Katie, primary, Williamson, Alice, additional, Kincaid, John W R, additional, Rainbow, Kara, additional, Corbin, Laura J, additional, Martin, Hilary C, additional, Eberhardt, Ruth Y, additional, Huang, Qin Qin, additional, Hurles, Matthew E, additional, He, Wen, additional, Brauner, Raja, additional, Delaney, Angela, additional, Dunkel, Leo, additional, Grinspon, Romina P, additional, Hall, Janet E, additional, Hirschhorn, Joel N, additional, Howard, Sasha R, additional, Latronico, Ana C, additional, Jorge, Alexander A L, additional, McElreavey, Ken, additional, Mericq, Verónica, additional, Merino, Paulina M, additional, Palmert, Mark R, additional, Plummer, Lacey, additional, Rey, Rodolfo A, additional, Rezende, Raíssa C, additional, Seminara, Stephanie B, additional, Salnikov, Kathryn, additional, Banerjee, Indraneel, additional, Lam, Brian Y H, additional, Perry, John R B, additional, Timpson, Nicholas J, additional, Clayton, Peter, additional, Chan, Yee-Ming, additional, Ong, Ken K, additional, and O’Rahilly, Stephen, additional
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- 2023
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40. Protein-truncating variants inBSNare associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease
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Zhao, Yajie, primary, Chukanova, Maria, additional, Kentistou, Katherine A, additional, Fairhurst-Hunter, Zammy, additional, Siegert, Anna Maria, additional, Jia, Raina, additional, Dowsett, Georgina, additional, Gardner, Eugene J, additional, Day, Felix R, additional, Kaisinger, Lena R, additional, Tung, Yi-Chun Loraine, additional, Hong Lam, Brian Yee, additional, Chen, Hsiao-Jou Cortina, additional, Wang, Quanli, additional, Berumen-Campos, Jaime, additional, Kuri-Morales, Pablo, additional, Tapia-Conyer, Roberto, additional, Alegre-Diaz, Jesus, additional, Emberson, Jonathan, additional, Torres, Jason M, additional, Collins, Rory, additional, Saleheen, Danish, additional, Smith, Katherine R, additional, Paul, Dirk S, additional, Merkle, Florian, additional, Wareham, Nick J, additional, Petrovski, Slavé, additional, O’Rahilly, Steve, additional, Ong, Ken K, additional, Yeo, Giles S H, additional, and Perry, John R B, additional
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- 2023
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41. The association between the timing, intensity and magnitude of adolescent growth and body composition in early adulthood
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Nyati, Lukhanyo H., primary, Pettifor, John M., additional, Ong, Ken K., additional, and Norris, Shane A., additional
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- 2023
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42. Manuscript title: Ultra-processed food consumption in UK adolescents: distribution, trends, and sociodemographic correlates using the National Diet and Nutrition Survey 2008/09 to 2018/19
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Chavez-Ugalde, Yanaina, primary, De Vocht, Frank, additional, Jago, Russell, additional, Adams, Jean, additional, Ong, Ken K., additional, Forouhi, Nita, additional, Colombet, Zoé, additional, Ricardo, Luiza I.C., additional, Van Sluijs, Esther, additional, and Toumpakari, Zoi, additional
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- 2023
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43. Pre-pubertal accelerometer-assessed physical activity and timing of puberty in British boys and girls: the Millennium Cohort Study
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Cheng, Tuck Seng, primary, Brage, Soren, additional, van Sluijs, Esther M F, additional, and Ong, Ken K, additional
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- 2023
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44. Leptin and IGF-1 in Infancy Are Associated With Variants in DHCR7 and CYP2R1 That Relate With Type 1 Diabetes and 25OHD
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Eleftheriou, Antigoni, primary, Ong, Ken K, additional, Hughes, Ieuan A, additional, and Petry, Clive J, additional
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- 2023
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45. Genetic impacts on DNA methylation help elucidate regulatory genomic processes
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Villicana, Sergio, primary, Castillo-Fernandez, Juan, additional, Hannon, Eilis, additional, Christiansen, Colette, additional, Tsai, Pei-Chien, additional, Maddock, Jane, additional, Kuh, Diana, additional, Suderman, Matthew, additional, Power, Christine, additional, Relton, Caroline, additional, Ploubidis, George, additional, Wong, Andrew, additional, Hardy, Rebecca, additional, Goodman, Alissa, additional, Ong, Ken K., additional, and Bell, Jordana T., additional
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- 2023
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46. Genetic links between ovarian ageing, cancer risk and de novo mutation rates
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Stankovic, Stasa, Shekari, Saleh, Huang, Qin Qin, Gardner, Eugene J., Ivarsdottir, Erna V., Owens, Nick D. L., Mavaddat, Nasim, Azad, Ajuna, Hawkes, Gareth, Kentistou, Katherine A., Beaumont, Robin N., Day, Felix R., Zhao, Yajie, Jonsson, Hakon, Rafnar, Thorunn, Tragante, Vinicius, Sveinbjornsson, Gardar, Oddsson, Asmundur, Styrkarsdottir, Unnur, Gudmundsson, Julius, Stacey, Simon N., Gudbjartsson, Daniel F., Kennedy, Kitale, Wood, Andrew R., Weedon, Michael N., Ong, Ken K., Wright, Caroline F., Hoffmann, Eva R., Sulem, Patrick, Hurles, Matthew E., Ruth, Katherine S., Martin, Hilary C., Stefansson, Kari, Perry, John R. B., and Murray, Anna
- Abstract
Human genetic studies of common variants have provided substantial insight into the biological mechanisms that govern ovarian ageing1. Here we report analyses of rare protein-coding variants in 106,973 women from the UK Biobank study, implicating genes with effects around five times larger than previously found for common variants (ETAA1, ZNF518A, PNPLA8, PALB2and SAMHD1). The SAMHD1association reinforces the link between ovarian ageing and cancer susceptibility1, with damaging germline variants being associated with extended reproductive lifespan and increased all-cause cancer risk in both men and women. Protein-truncating variants in ZNF518Aare associated with shorter reproductive lifespan—that is, earlier age at menopause (by 5.61 years) and later age at menarche (by 0.56 years). Finally, using 8,089 sequenced trios from the 100,000 Genomes Project (100kGP), we observe that common genetic variants associated with earlier ovarian ageing associate with an increased rate of maternally derived de novo mutations. Although we were unable to replicate the finding in independent samples from the deCODE study, it is consistent with the expected role of DNA damage response genes in maintaining the genetic integrity of germ cells. This study provides evidence of genetic links between age of menopause and cancer risk.
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- 2024
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47. Association between perinatal factors, genetic susceptibility to obesity and age at adiposity rebound in children of the EDEN mother–child cohort
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Cissé, Aminata Hallimat, Lioret, Sandrine, de Lauzon-Guillain, Blandine, Forhan, Anne, Ong, Ken K., Charles, Marie Aline, and Heude, Barbara
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Background: Early adiposity rebound (AR) has been associated with increased risk of overweight or obesity in adulthood. However, little is known about early predictors of age at AR. We aimed to study the role of perinatal factors and genetic susceptibility to obesity in the kinetics of AR. Methods: Body mass index (BMI) curves were modelled by using mixed-effects cubic models, and age at AR was estimated for 1415 children of the EDEN mother–child cohort study. A combined obesity risk-allele score was calculated from genotypes for 27 variants identified by genome-wide association studies of adult BMI. Perinatal factors of interest were maternal age at delivery, parental education, parental BMI, gestational weight gain, maternal smoking during pregnancy, and newborn characteristics (sex, prematurity, and birth weight). We used a hierarchical level approach with multivariable linear regression model to investigate the association between these factors, obesity risk-allele score, and age at AR. Results: A higher genetic susceptibility to obesity score was associated with an earlier age at AR. At the most distal level of the hierarchical model, maternal and paternal educational levels were positively associated with age at AR. Children born to parents with higher BMI were more likely to exhibit earlier age at AR. In addition, higher gestational weight gain was related to earlier age at AR. For children born small for gestational age, the average age at AR was 88 [±39] days lower than for children born appropriate for gestational age and 91 [±56] days lower than for children born large for gestational age. Conclusion: The timing of AR seems to be an early childhood manifestation of the genetic susceptibility to adult obesity. We further identified low birth weight and gestational weight gain as novel predictors of early AR, highlighting the role of the intrauterine environment in the kinetics of adiposity.
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- 2024
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48. The association between the timing, intensity and magnitude of adolescent growth and body composition in early adulthood
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Nyati, Lukhanyo H, Pettifor, John M, Ong, Ken K, Norris, Shane A, Nyati, Lukhanyo H [0000-0003-0975-344X], Norris, Shane A [0000-0001-7124-3788], and Apollo - University of Cambridge Repository
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Pediatric ,Clinical Research ,Prevention ,Contraception/Reproduction ,32 Biomedical and Clinical Sciences ,Obesity ,Generic health relevance ,3213 Paediatrics ,Metabolic and endocrine ,Nutrition - Abstract
OBJECTIVES: There's paucity of longitudinal studies assessing the role of adolescent growth on adult body composition in developing countries. The aims of this study were to assess the association between adolescent change in height, weight and BMI and early adult height, weight, body fat and lean mass. METHODS: Magnitude, timing and intensity of height, weight and BMI growth were modelled for participants from the Birth to Thirty (Bt30) cohort (7-23 years). Early adult height, weight, BMI and DXA-derived body composition were obtained 1881 black participants (21-24 years). Linear regression analyses were used to assess associations. RESULTS: Adolescents with an earlier onset of puberty were heavier in childhood and had an earlier timing and faster weight gain velocity in late adolescence. The intensity of adolescent weight gain was positively associated with adult BMI and fat mass index (FMI) in females. Early timing of adolescent BMI gain was associated with increased weight and BMI in adult females and FMI in adult males. Achieving peak weight velocity around age at peak height velocity was associated with lower BMI and fat mass in both sexes. CONCLUSION: This study confirms the adverse consequences of excessive weight gain prior to puberty, which is associated with an earlier and faster resurgence in weight gain velocity in early adulthood. Factors that contribute to an asynchronous timing of ages of peak weight and peak height velocities may accentuate the risk of adult obesity.
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- 2023
49. Early development of infant gut microbiota in relation to breastfeeding and human milk oligosaccharides
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Chichlowski, Maciej, primary, van Diepen, Janna A., additional, Prodan, Andrei, additional, Olga, Laurentya, additional, Ong, Ken K., additional, Kortman, Guus A. M., additional, Dunger, David B., additional, and Gross, Gabriele, additional
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- 2023
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50. Prospective Associations of Accelerometer-Measured Physical Activity with Polycystic Ovary Syndrome Features Among Adolescent Girls in the Avon Longitudinal Study of Parents and Children
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Peters, Tricia, primary, Chen, Tuck Seng, additional, Brage, Soren, additional, and Ong, Ken K., additional
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- 2023
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