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203 results on '"Ohashi, Takuma"'

7. Comparison of standardized prophylactic high-dose and intrathecal methotrexate for DLBCL with a high risk of CNS relapse

Author

Akimoto, Masahiro, Miyazaki, Takuya, Takahashi, Hiroyuki, Saigusa, Yusuke, Takeda, Takaaki, Hibino, Yuto, Tokunaga, Mayumi, Ohashi, Takuma, Matsumura, Ayako, Teshigawara, Haruka, Suzuki, Taisei, Teranaka, Hiroshi, Nakajima, Yuki, Matsumoto, Kenji, Hashimoto, Chizuko, Fujimaki, Katsumichi, Fujita, Hiroyuki, Sakai, Rika, Fujisawa, Shin, and Nakajima, Hideaki

Published
2024
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16. Impact of standard-dose dipeptidyl peptidase-4 inhibitors on the incidence of graft-versus-host disease after allogeneic hematopoietic cell transplantation

Author

Kimura, Shun-ichi, Shimizu, Hiroaki, Miyazaki, Takuya, Sakurai, Masatoshi, Tanoue, Susumu, Kayamori, Kensuke, Ohwada, Chikako, Yoshimura, Kazuki, Nakasone, Hideki, Ohashi, Takuma, Shono, Katsuhiro, Tachibana, Takayoshi, Hatano, Kaoru, Okada, Keigo, Kimura, Yuta, Seo, Sachiko, Doki, Noriko, Tanaka, Masatsugu, Hatta, Yoshihiro, Takahashi, Satoshi, and Kanda, Yoshinobu

Published
2023
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25. Extracellular glypican‐1 affects tumor progression and prognosis in esophageal cancer.

Author

Shibata, Rie, Konishi, Hirotaka, Arita, Tomohiro, Yamamoto, Yusuke, Matsuda, Hayato, Yamamoto, Taiga, Ohashi, Takuma, Shimizu, Hiroki, Komatsu, Shuhei, Shiozaki, Atsushi, Kubota, Takeshi, Fujiwara, Hitoshi, and Otsuji, Eigo

Subjects
CANCER cell motility, METASTASIS, CANCER invasiveness, CANCER patients, TUMOR growth, ESOPHAGEAL cancer
Abstract

Introduction: Cells are covered with a glycan surface layer that is referred to as the glycocalyx (GCX). It has been reported that the formation of the GCX is promoted on cancer cells and is associated with tumor growth and metastasis. Heparan sulfate proteoglycan glypican‐1 (GPC1) is a core protein of the GCX that is overexpressed in esophageal squamous cell carcinoma (ESCC) and is involved in the development and progression of cancer cells. The purpose of the present study is to analyze the utility of GPC1 as a new biomarker ralated to glycocalyx that reflects therapeutic effect and prognosis of ESCC. Methods: We measured the concentration of GPC1 protein in preoperative plasma from advanced esophageal cancer patients and examined its relationships with clinicopathological factors and therapeutic efficacy, and the effects of extracellular GPC1 were investigated. Results: The following clinical factors were significantly correlated with the preoperative high GPC1 concentration: male, tumor size ≥30 mm, venous invasion, pT factor ≥2, pStage ≥3, residual tumor, and distant metastatic recurrence. Both overall and recurrence‐free survival were significantly worse in the high GPC1 group. Extracellular GPC1 protein concentration reflected intracellular GPC1 expression. Furthermore, we examined the effects of extracellular recombinant human (rh)GPC1 on ESCC cells, and found that extracellular rhGPC1 affects cell motility, including migration and invasion. Conclusions: These results demonstrated the utility of extracellular GPC1 as a biomarker, which can be assayed from a less invasive blood sample‐based liquid biopsy. Extracellular GPC1 protein plays a role in both tumor cell motility and cancer progression. Thus, plasma GPC1 is a useful biomarker for esophageal cancer progression and may be a potential candidate of therapeutic target. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Dropped head syndrome suspected due to oxaliplatin used in adjuvant chemotherapy for gastric cancer: a case report.

Author

Marunaka, Yuta, Ohashi, Takuma, Kubota, Takeshi, Nishibeppu, Keiji, Konishi, Hirotaka, Shiozaki, Atsushi, Fujiwara, Hitoshi, and Otsuji, Eigo

Subjects
DROPPED head syndrome, ADJUVANT chemotherapy, CANCER chemotherapy, STOMACH cancer, NECK pain, OXALIPLATIN
Abstract

Background: Dropped head syndrome (DHS) is caused by dysfunction of the cervical musculature. It is classified into two groups according to the cause: one is weakness of the neck extensors and the other is hypercontraction of the cervical flexors associated with Parkinson's disease and other disorders. Although some drugs have previously been reported as suspected causes of DHS, we are unaware of any reports in which oxaliplatin was suspected. In this report, we describe a case of DHS during adjuvant chemotherapy for gastric cancer, along with a review of the relevant literature. Case presentation: A 72-year-old man was diagnosed with gastric cancer, cT3N0M0 cStage IIB, and underwent laparoscopic total gastrectomy with D2 lymphnode dissection and Roux-en-Y reconstruction. The operative time was 311 min, intraoperative blood loss was 40 g, and he was discharged without any post-operative complications. The histopathological diagnosis was pT4aN2M0 pStage IIIA, and S-1 + oxaliplatin (SOX) therapy was started as adjuvant chemotherapy. On the 4th course of SOX, he complained of neck heaviness and a blood test revealed that his creatine kinase (CK) level was elevated to 2464 IU/L. After consultation with an orthopedic surgeon and a neurologist, DHS due to localized cervical extensor myositis was suspected. Therefore, the 6th course of SOX was postponed, and 30 mg of oral steroids were initiated. His symptoms improved, and his CK level decreased within 2 weeks. After resuming S-1 monotherapy and tapering off oral steroids, no recurrence of symptoms has been observed. Conclusions: We experienced one case of DHS during adjuvant chemotherapy for gastric cancer. If DHS develops after starting oxaliplatin, involvement of the drug should be suspected, and discontinuation of chemotherapy and introduction of oral steroids should be considered. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Low blood level of tumour suppressor miR-5193 as a target of immunotherapy to PD-L1 in gastric cancer

Author

Kamiya, Hajime, primary, Komatsu, Shuhei, additional, Takashima, Yusuke, additional, Ishida, Ryo, additional, Arakawa, Hiroshi, additional, Nishibeppu, Keiji, additional, Kiuchi, Jun, additional, Imamura, Taisuke, additional, Ohashi, Takuma, additional, Shimizu, Hiroki, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Shiozaki, Atsushi, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Yagyu, Shigeki, additional, Iehara, Tomoko, additional, and Otsuji, Eigo, additional

Published
2023
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36. Lymphovascular invasion is associated with poor long-term outcomes in patients with pT1N0-3 or pT2-3N0 remnant gastric cancer: a retrospective cohort study.

Author

Sumiyoshi, Shutaro, Ohashi, Takuma, Kubota, Takeshi, Nishibeppu, Keiji, Owada, Kaho, Kiuchi, Jun, Shimizu, Hiroki, Arita, Tomohiro, Iitaka, Daisuke, Yamamoto, Yusuke, Konishi, Hirotaka, Morimura, Ryo, Watanabe, Kenji, Kuriu, Yoshiaki, Shiozaki, Atsushi, Ikoma, Hisashi, Fujiwara, Hitoshi, Yamaoka, Nobuki, and Otsuji, Eigo

Subjects
*STOMACH cancer, *PROPORTIONAL hazards models, *TREATMENT effectiveness, *ADJUVANT chemotherapy, *COHORT analysis
Abstract

Background: Lymphovascular invasion (LVI) is a poor prognostic factor in various malignancies. However, its prognostic effect in remnant gastric cancer (RGC) remains unclear. We examined the correlation between LVI and disease prognosis in patients with T1N0-3 or T2-3N0 RGC in whom adjuvant chemotherapy was not indicated and a treatment strategy was not established. Methods: We retrospectively analyzed patients with T1N0-3 and T2-3N0 RGC who underwent curative surgery at the Kyoto Prefectural University of Medicine between 1997 and 2019 and at the Kyoto Chubu Medical Center between 2009 and 2019. Results: Fifteen of 38 patients (39.5%) with RGC were positive for LVI. Patients with LVI had a significantly poorer prognosis for both overall survival ([OS]: P = 0.006) and recurrence-free survival ([RFS]: P = 0.001) than those without LVI. Multivariate analyses using the Cox proportional hazards model revealed LVI as an independent prognostic factor affecting OS (P = 0.024; hazard ratio 8.27, 95% confidence interval:1.285–161.6) and RFS (P = 0.013; hazard ratio 8.98, 95% confidence interval:1.513–171.2). Conclusions: LVI is a prognostic factor for patients with T1N0-3 or T2-3N0 RGC. Evaluating LVI may be useful for determining treatment strategies for RGC. [ABSTRACT FROM AUTHOR]

Published
2024
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37. MO49-1 The efficacy of high-dose versus intrathecal methotrexate for DLBCL with high risk of CNS relapse: A multicenter retrospective study

Author

Akimoto, Masahiro, primary, Miyazaki, Takuya, additional, Takahashi, Hiroyuki, additional, Saigusa, Yusuke, additional, Takeda, Takaaki, additional, Hibino, Yuto, additional, Tokunaga, Mayumi, additional, Ohashi, Takuma, additional, Matsumura, Ayako, additional, Teshigawara, Haruka, additional, Suzuki, Taisei, additional, Teranaka, Hiroshi, additional, Nakajima, Yuki, additional, Matsumoto, Kenji, additional, Hashimoto, Chizuko, additional, Fujimaki, Katsumichi, additional, Fujita, Hiroyuki, additional, Sakai, Rika, additional, Fujisawa, Shin, additional, and Nakajima, Hideaki, additional

Published
2023
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38. Preoperative oral antibiotic administration in patients undergoing curative resection with stoma creation for colorectal cancer: effectiveness in preventing surgical site infection and the possibility of peristomal candidiasis induced by enterobacterial alteration

Author

Kiuchi, Jun, primary, Kuriu, Yoshiaki, additional, Arita, Tomohiro, additional, Shimizu, Hiroki, additional, Nanishi, Kenji, additional, Takaki, Wataru, additional, Ohashi, Takuma, additional, Konishi, Hirotaka, additional, Yamamoto, Yusuke, additional, Morimura, Ryo, additional, Shiozaki, Atsuishi, additional, Ikoma, Hisashi, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, and Otsuji, Eigo, additional

Published
2023
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40. 395. SURGICAL PROCEDURE AND PERIOPERATIVE OUTCOME OF TRANSMEDIASTINAL ESOPHAGECTOMY FOR ESOPHAGOGASTRIC JUNCTION CANCER

Author

Shiozaki, Atsushi, primary, Fujiwara, Hitoshi, additional, Konishi, Hirotaka, additional, Nishibeppu, Keiji, additional, Ohashi, Takuma, additional, Shimizu, Hiroki, additional, Arita, Tomohiro, additional, Yamamoto, Yusuke, additional, Morimura, Ryo, additional, Kuriu, Yoshiaki, additional, Ikoma, Hisashi, additional, Kubota, Takeshi, additional, and Otsuji, Eigo, additional

Published
2023
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41. 436. USEFULNESS OF INTRAOPERATIVE CONTINUOUS NERVE MONITORING IN TRANSMEDIASTINAL MINIMALLY INVASIVE ESOPHAGECTOMY

Author

Nakamichi, Naosuke, primary, Fujiwara, Hitoshi, additional, Shiozaki, Atsushi, additional, Konishi, Hirotaka, additional, Inoue, Hiroyuki, additional, Nishibeppu, Keiji, additional, Ohashi, Takuma, additional, Shimizu, Hiroki, additional, Arita, Tomohiro, additional, Yamamoto, Yusuke, additional, Morimura, Ryo, additional, Kuriu, Yoshiaki, additional, Ikoma, Hisashi, additional, Kubota, Takeshi, additional, and Otsuji, Eigo, additional

Published
2023
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43. 424. EXPRESSION OF KCNB1 AND ITS RELATION TO TUMOR PROGRESSION IN ESOPHAGEAL CANCER

Author

Ota, Atsuki, primary, Shiozaki, Atsushi, additional, Nishibeppu, Keiji, additional, Kiuchi, Jun, additional, Ohashi, Takuma, additional, Shimizu, Hiroki, additional, Arita, Tomohiro, additional, Yamamoto, Yusuke, additional, Konishi, Hirotaka, additional, Morimura, Ryo, additional, Kuriu, Yoshiaki, additional, Ikoma, Hisashi, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, and Otsuji, Eigo, additional

Published
2023
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44. Plasma miR ‐1254 as a predictive biomarker of chemosensitivity and a target of nucleic acid therapy in esophageal cancer

Author

Takashima, Yusuke, primary, Komatsu, Shuhei, additional, Ohashi, Takuma, additional, Kiuchi, Jun, additional, Nishibeppu, Keiji, additional, Kamiya, Hajime, additional, Arakawa, Hiroshi, additional, Ishida, Ryo, additional, Shimizu, Hiroki, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Shiozaki, Atsushi, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, and Otsuji, Eigo, additional

Published
2023
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45. Incidence and Risk of Hematological Adverse Events Associated With Immune Checkpoint Inhibitors: A Systematic Literature Review and Meta-Analysis

Author

Ohashi, Takuma, primary, Takase-Minegishi, Kaoru, additional, Maeda, Ayaka, additional, Hamada, Naoki, additional, Yoshimi, Ryusuke, additional, Kirino, Yohei, additional, Teranaka, Hiroshi, additional, Kunimoto, Hiroyoshi, additional, Hagihara, Maki, additional, Matsumoto, Kenji, additional, Namkoong, Ho, additional, Horita, Nobuyuki, additional, and Nakajima, Hideaki, additional

Published
2023
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47. Additional file 4 of Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study

Author

Sumiyoshi, Shutaro, Kiuchi, Jun, Kuriu, Yoshiaki, Arita, Tomohiro, Shimizu, Hiroki, Takaki, Wataru, Ohashi, Takuma, Yamamoto, Yusuke, Konishi, Hirotaka, Morimura, Ryo, Shiozaki, Atsushi, Ikoma, Hisashi, Kubota, Takeshi, Fujiwara, Hitoshi, Okamoto, Kazuma, and Otsuji, Eigo

Abstract

Additional file 4: Table S3. Changes in hepatobiliary enzymes in patient withpostoperative liver dysfunction.

Published
2023
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48. Additional file 5 of Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study

Author

Sumiyoshi, Shutaro, Kiuchi, Jun, Kuriu, Yoshiaki, Arita, Tomohiro, Shimizu, Hiroki, Takaki, Wataru, Ohashi, Takuma, Yamamoto, Yusuke, Konishi, Hirotaka, Morimura, Ryo, Shiozaki, Atsushi, Ikoma, Hisashi, Kubota, Takeshi, Fujiwara, Hitoshi, Okamoto, Kazuma, and Otsuji, Eigo

Abstract

Additional file 5: Table S4. The association between postoperative liverdysfunction and Stage III CRC patient characteristics.

Published
2023
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49. Additional file 3 of Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study

Author

Sumiyoshi, Shutaro, Kiuchi, Jun, Kuriu, Yoshiaki, Arita, Tomohiro, Shimizu, Hiroki, Takaki, Wataru, Ohashi, Takuma, Yamamoto, Yusuke, Konishi, Hirotaka, Morimura, Ryo, Shiozaki, Atsushi, Ikoma, Hisashi, Kubota, Takeshi, Fujiwara, Hitoshi, Okamoto, Kazuma, and Otsuji, Eigo

Abstract

Additional file 3: Table S2. The association between postoperative comorbiditiesand postoperative liver dysfunction.

Published
2023
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