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305 results on '"Obara, Wataru"'

7. Effect of genetic polymorphisms on outcomes following nivolumab for advanced renal cell carcinoma in the SNiP-RCC trial

Author

Shiota, Masaki, Miyake, Hideaki, Takahashi, Masayuki, Oya, Mototsugu, Tsuchiya, Norihiko, Masumori, Naoya, Matsuyama, Hideyasu, Obara, Wataru, Shinohara, Nobuo, Fujimoto, Kiyohide, Nozawa, Masahiro, Ohba, Kojiro, Ohyama, Chikara, Hashine, Katsuyoshi, Akamatsu, Shusuke, Kamba, Tomomi, Mita, Koji, Gotoh, Momokazu, Tatarano, Shuichi, Fujisawa, Masato, Tomita, Yoshihiko, Mukai, Shoichiro, Ito, Keiichi, Tanegashima, Tokiyoshi, Tokunaga, Shoji, and Eto, Masatoshi

Published
2023
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8. Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals

Author

Matsuda, Koichi, Yamanashi, Yuji, Furukawa, Yoichi, Morisaki, Takayuki, Okada, Yukinori, Murakami, Yoshinori, Muto, Kaori, Nagai, Akiko, Nakamura, Yusuke, Obara, Wataru, Yamaji, Ken, Takahashi, Kazuhisa, Asai, Satoshi, Takahashi, Yasuo, Higashiue, Shinichi, Kobayashi, Shuzo, Yamaguchi, Hiroki, Nagata, Yasunobu, Wakita, Satoshi, Nito, Chikako, Iwasaki, Yu-Ki, Murayama, Shigeo, Yoshimori, Kozo, Miki, Yoshio, Obata, Daisuke, Higashiyama, Masahiko, Masumoto, Akihide, Koga, Yoshinobu, Koretsune, Yukihiro, Aihara, Makoto, Sakata, Rei, Kashiwagi, Kenji, Mabuchi, Fumihiko, Kawase, Kazuhide, Iwata, Takeshi, Tsujikawa, Motokazu, Nishiguchi, Koji M., Akiyama, Masato, Tamiya, Gen, Fujiwara, Kohta, Shiga, Yukihiro, Yokoyama, Yu, Hashimoto, Kazuki, Sato, Masataka, Sato, Kota, Narita, Akira, Hashimoto, Sawako, Ueda, Emi, Furuta, Yoshihiko, Hata, Jun, Miyake, Masahiro, Ikeda, Hanako O., Suda, Kenji, Numa, Shogo, Mori, Yuki, Morino, Kazuya, Murakami, Yusuke, Shimokawa, Sakurako, Nakamura, Shun, Yawata, Nobuyo, Fujisawa, Kimihiko, Yamana, Satoshi, Mori, Kenichiro, Ikeda, Yasuhiro, Miyata, Kazunori, Mori, Keisuke, Ogino, Ken, Koyanagi, Yoshito, Kamatani, Yoichiro, Ninomiya, Toshiharu, Sonoda, Koh-Hei, and Nakazawa, Toru

Published
2024
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10. Impact of exposure on outcomes with enfortumab vedotin in patients with locally advanced or metastatic urothelial cancer.

Author

Petrylak, Daniel P., primary, Chia, Yen Lin, additional, Yu, Evan Y., additional, Powles, Thomas, additional, Flaig, Thomas W., additional, Loriot, Yohann, additional, O'Donnell, Peter H., additional, Heath, Elisabeth I., additional, Kojima, Takahiro, additional, Park, Se Hoon, additional, Sonpavde, Guru P., additional, Picus, Joel, additional, Matsubara, Nobuaki, additional, Obara, Wataru, additional, Chudasama, Vaishali, additional, Poondru, Srinivasu, additional, Harrison, Michael, additional, Kim, Eric, additional, Brancato, Sam Joseph, additional, and Rosenberg, Jonathan E., additional

Published
2024
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13. PD61-11 INITIAL EXPERIENCE OF ROBOT-ASSISTED RADICAL PROSTATECTOMY USING HINOTORI SURGICAL ROBOT SYSTEM

Author

Kanehira, Mitsugu, primary, Moriwaka, Makoto, additional, Toyoshima, Moe, additional, Kurokawa, Masahiro, additional, Takahashi, Kenta, additional, Shiomi, Ei, additional, Ishii, Shuhei, additional, Ikarashi, Daiki, additional, Maekawa, Shigekatsu, additional, Kato, Renpei, additional, Takata, Ryo, additional, Sugimura, Jun, additional, Abe, Takaya, additional, and Obara, Wataru, additional

Published
2024
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15. PD41-06 EVALUATION OF THE TUMOR MICROENVIRONMENT OF UPPER TRACT UROTHELIAL CARCINOMA USING MULTIPLEX FLUORESCENCE IMMUNOHISTOCHEMISTRY

Author

Takahashi, Kenta, primary, Ikarashi, Daiki, additional, Kawamura, Tatsuya, additional, Shiomi, Ei, additional, Matsuura, Tomohiko, additional, Maekawa, Shigekatsu, additional, Kato, Renpei, additional, Kanehira, Mitsugu, additional, Sugimura, Jun, additional, Abe, Takaya, additional, and Obara, Wataru, additional

Published
2024
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16. MP05-19 POLYGENETIC RISK SCORE FOR PROSTATE CANCER IS ASSOCIATED WITH LIPOPOLYSACCHARIDE PATHWAY IN GUT MICROBIOME

Author

Hatano, Koji, primary, Tomofuji, Yoshihiko, additional, Matsushita, Makoto, additional, Oka, Toshiki, additional, Motooka, Daisuke, additional, Fujimoto, Saizo, additional, Hata, Junya, additional, Tsujimura, Akira, additional, Obara, Wataru, additional, Nakamura, Shota, additional, Uemura, Hirotsugu, additional, Okada, Yukinori, additional, Nonomura, Norio, additional, and Fujita, Kazutoshi, additional

Published
2024
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17. Supplementary Tables S1-S5 from TAS0313 plus Pembrolizumab for Post-Chemotherapy Immune Checkpoint Inhibitor—Naïve Locally Advanced or Metastatic Urothelial Carcinoma

Author

Nishiyama, Hiroyuki, primary, Yonese, Junji, primary, Kawahara, Takashi, primary, Matsumoto, Ryuji, primary, Miyake, Hideaki, primary, Matsubara, Nobuaki, primary, Uemura, Hiroji, primary, Eto, Masatoshi, primary, Azuma, Haruhito, primary, Obara, Wataru, primary, Terai, Akito, primary, Fukasawa, Satoshi, primary, and Suekane, Shigetaka, primary

Published
2024
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18. Data from TAS0313 plus Pembrolizumab for Post-Chemotherapy Immune Checkpoint Inhibitor—Naïve Locally Advanced or Metastatic Urothelial Carcinoma

Author

Nishiyama, Hiroyuki, primary, Yonese, Junji, primary, Kawahara, Takashi, primary, Matsumoto, Ryuji, primary, Miyake, Hideaki, primary, Matsubara, Nobuaki, primary, Uemura, Hiroji, primary, Eto, Masatoshi, primary, Azuma, Haruhito, primary, Obara, Wataru, primary, Terai, Akito, primary, Fukasawa, Satoshi, primary, and Suekane, Shigetaka, primary

Published
2024
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19. Supplementary Legends from TAS0313 plus Pembrolizumab for Post-Chemotherapy Immune Checkpoint Inhibitor—Naïve Locally Advanced or Metastatic Urothelial Carcinoma

Author

Nishiyama, Hiroyuki, primary, Yonese, Junji, primary, Kawahara, Takashi, primary, Matsumoto, Ryuji, primary, Miyake, Hideaki, primary, Matsubara, Nobuaki, primary, Uemura, Hiroji, primary, Eto, Masatoshi, primary, Azuma, Haruhito, primary, Obara, Wataru, primary, Terai, Akito, primary, Fukasawa, Satoshi, primary, and Suekane, Shigetaka, primary

Published
2024
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20. Supplementary Figure S1 from TAS0313 plus Pembrolizumab for Post-Chemotherapy Immune Checkpoint Inhibitor—Naïve Locally Advanced or Metastatic Urothelial Carcinoma

Author

Nishiyama, Hiroyuki, primary, Yonese, Junji, primary, Kawahara, Takashi, primary, Matsumoto, Ryuji, primary, Miyake, Hideaki, primary, Matsubara, Nobuaki, primary, Uemura, Hiroji, primary, Eto, Masatoshi, primary, Azuma, Haruhito, primary, Obara, Wataru, primary, Terai, Akito, primary, Fukasawa, Satoshi, primary, and Suekane, Shigetaka, primary

Published
2024
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21. WCN24-244 The utility of Indoxyl sulfate as a biomarker for early detection of CKD

Author

Hisano, Mizuki, primary, Abe, Takaya, additional, Sekiguchi, Kie, additional, Shiomi, Ei, additional, Ishii, Shuhei, additional, Matsuura, Tomohiko, additional, Maekawa, Shigekatsu, additional, Kato, Renpei, additional, Kanehira, Mistugu, additional, Takata, Ryo, additional, Sugimura, Jun, additional, Tanno, Kozo, additional, Abe, Toshikazu, additional, Tatsumi, Kenta, additional, and Obara, Wataru, additional

Published
2024
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22. WCN24-866 THE TYPE OF HEPARIN USED FOR ANTICOAGULATION IN PATIENTS ON HEMODIALYSIS AFFECTS CARNITINE METABOLISM

Author

Sekiguchi, Kie, primary, Abe, Takaya, additional, Shiomi, Ei, additional, Ikarashi, Daiki, additional, Matsuura, Tomohiko, additional, Maekawa, Shigekatsu, additional, Kato, Renpei, additional, Kanehira, Mitsugu, additional, Takata, Ryo, additional, Sugimura, Jun, additional, Sekiguchi, Takashi, additional, and Obara, Wataru, additional

Published
2024
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24. Correction to: Significance of upfront cytoreductive nephrectomy stratified by IMDC risk for metastatic renal cell carcinoma in targeted therapy era – a multi‑institutional retrospective study

Author

Kato, Renpei, Naito, Sei, Numakura, Kazuyuki, Hatakeyama, Shingo, Koguchi, Tomoyuki, Kojima, Takahiro, Kawasaki, Yoshihide, Kandori, Shuya, Kawamura, Sadafumi, Arai, Yoichi, Ito, Akihiro, Nishiyama, Hiroyuki, Kojima, Yoshiyuki, Ohyama, Chikara, Habuchi, Tomonori, Tsuchiya, Norihiko, and Obara, Wataru

Published
2023
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26. Significance of upfront cytoreductive nephrectomy stratified by IMDC risk for metastatic renal cell carcinoma in targeted therapy era – a multi-institutional retrospective study

Author

Kato, Renpei, Naito, Sei, Numakura, Kazuyuki, Hatakeyama, Shingo, Koguchi, Tomoyuki, Kojima, Takahiro, Kawasaki, Yoshihide, Kandori, Shuya, Kawamura, Sadafumi, Arai, Yoichi, Ito, Akihiro, Nishiyama, Hiroyuki, Kojima, Yoshiyuki, Ohyama, Chikara, Habuchi, Tomonori, Tsuchiya, Norihiko, and Obara, Wataru

Published
2022
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27. Emphysematous pyelonephritis diagnosed by acute changes detected via computed tomography: A case report.

Author

Kato, Yoichiro, Ishii, Shuhei, Goto, Yuta, Nozaki, Yasushi, Kawamura, Tatsuya, Morino, Gota, Hoshi, Shintaro, Takahashi, Gaku, and Obara, Wataru

Subjects
URINARY tract infections, COMPUTED tomography, CONSERVATIVE treatment, DIABETES, REFRACTORY materials
Abstract

Key Clinical Message: This is the first case report in which computed tomography (CT) images of a patient with emphysematous pyelonephritis (EPN) capture the time course of emphysema from onset to resolution through conservative treatment. To re‐evaluate EPN, including refractory urinary tract infections, CT scans after 72 h might be helpful. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss.

Author

Sonehara, Kyuto, Yano, Yoshitaka, Naito, Tatsuhiko, Goto, Shinobu, Yoshihara, Hiroyuki, Otani, Takahiro, Ozawa, Fumiko, Kitaori, Tamao, Yamanashi, Yuji, Furukawa, Yoichi, Morisaki, Takayuki, Murakami, Yoshinori, Kamatani, Yoichiro, Muto, Kaori, Nagai, Akiko, Nakamura, Yusuke, Obara, Wataru, Yamaji, Ken, Takahashi, Kazuhisa, and Asai, Satoshi

Subjects
RECURRENT miscarriage, GENETIC variation, GENOME-wide association studies, HAPLOTYPES, MAJOR histocompatibility complex, ANTIPHOSPHOLIPID syndrome
Abstract

Recurrent pregnancy loss (RPL) is a major reproductive health issue with multifactorial causes, affecting 2.6% of all pregnancies worldwide. Nearly half of the RPL cases lack clinically identifiable causes (e.g., antiphospholipid syndrome, uterine anomalies, and parental chromosomal abnormalities), referred to as unexplained RPL (uRPL). Here, we perform a genome-wide association study focusing on uRPL in 1,728 cases and 24,315 female controls of Japanese ancestry. We detect significant associations in the major histocompatibility complex (MHC) region at 6p21 (lead variant=rs9263738; P = 1.4 × 10−10; odds ratio [OR] = 1.51 [95% CI: 1.33–1.72]; risk allele frequency = 0.871). The MHC associations are fine-mapped to the classical HLA alleles, HLA-C*12:02, HLA-B*52:01, and HLA-DRB1*15:02 (P = 1.1 × 10−10, 1.5 × 10−10, and 1.2 × 10−9, respectively), which constitute a population-specific common long-range haplotype with a protective effect (P = 2.8 × 10−10; OR = 0.65 [95% CI: 0.57–0.75]; haplotype frequency=0.108). Genome-wide copy-number variation (CNV) calling demonstrates rare predicted loss-of-function (pLoF) variants of the cadherin-11 gene (CDH11) conferring the risk of uRPL (P = 1.3 × 10−4; OR = 3.29 [95% CI: 1.78–5.76]). Our study highlights the importance of reproductive immunology and rare variants in the uRPL etiology. Here, the authors perform a genome-wide association study for recurrent pregnancy loss without apparent clinical causes and identify a protective HLA haplotype. They also show that rare predicted loss-of-function variants in CDH11 are associated with risk of recurrent pregnancy loss. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Comparison of outcomes in kidney transplantations involving blood-related and non-blood-related living donors: a multicenter retrospective study by the Michinoku renal transplant network.

Author

Matsuura, Tomohiko, Toyoshima, Moe, Saitoh, Mitsuru, Nishida, Hayato, Hatakeyama, Shingo, Maita, Shinya, Murakami, Reiichi, Sugimura, Jun, Abe, Takaya, Tomita, Hirofumi, Saitoh, Hisao, Tsuchiya, Norihiko, Ohyama, Chikara, Habuchi, Tomonori, and Obara, Wataru

Published
2024
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31. Prognosis of Japanese metastatic renal cell carcinoma patients in the targeted therapy era

Author

Naito, Sei, Kato, Tomoyuki, Numakura, Kazuyuki, Hatakeyama, Shingo, Koguchi, Tomoyuki, Kandori, Shuya, Kawasaki, Yoshihide, Adachi, Hisanobu, Kato, Renpei, Narita, Shintaro, Yamamoto, Hayato, Ogawa, Soichiro, Kawamura, Sadafumi, Obara, Wataru, Ito, Akihiro, Nishiyama, Hiroyuki, Kojima, Yoshiyuki, Ohyama, Chikara, Habuchi, Tomonori, and Tsuchiya, Norihiko

Published
2021
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34. Pathological complete response to neoadjuvant chemotherapy may improve antitumor immune response via reduction of regulatory T cells in muscle-invasive bladder cancer

Author

Ikarashi, Daiki, primary, Kitano, Shigehisa, additional, Tsuyukubo, Takashi, additional, Yamashita, Makiko, additional, Matsuura, Tomohiko, additional, Maekawa, Shigekatsu, additional, Kato, Renpei, additional, Kato, Yoichiro, additional, Kanehira, Mitsugu, additional, Takata, Ryo, additional, Sugai, Tamotsu, additional, and Obara, Wataru, additional

Published
2024
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36. A case of complete response to avelumab plus axitinib combination therapy for metastatic clear cell renal cell carcinoma in a kidney undergoing dialysis

Author

Shiomi, Ei, primary, Goto, Yuta, additional, Hisano, Mizuki, additional, Ito, Rento, additional, Moriwaka, Makoto, additional, Ikarashi, Daiki, additional, Maekawa, Shigekatsu, additional, Kato, Renpei, additional, Kanehira, Mitsugu, additional, Ujiie, Takashi, additional, and Obara, Wataru, additional

Published
2024
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37. Abnormal carnitine metabolism in hemodialysis patients on different anticoagulants.

Author

Sekiguchi, Kie, Abe, Takaya, Shiomi, Ei, Ikarashi, Daiki, Matsuura, Tomohiko, Maekawa, Shigekatsu, Kato, Renpei, Kanehira, Mitsugu, Takata, Ryo, Sugimura, Jun, Sekiguchi, Takashi, and Obara, Wataru

Subjects
LOW-molecular-weight heparin, HEMODIALYSIS patients, CARNITINE, FREE fatty acids, ANTICOAGULANTS
Abstract

Introduction: We aimed to determine whether unfractionated heparin (UH) and low molecular weight heparin (LH) contribute to aberrant carnitine metabolism in patients receiving hemodialysis. Methods: The rate of increase in serum free fatty acids (FFAs) and the ratio of acylcarnitine to free carnitine (AC/FC) from before to after hemodialysis were determined in patients receiving UH and LH. Additionally, the effect of switching patients to UH from LH was examined. Results: AC/FC was significantly higher in the UH group. In addition, serum FFAs in that group increased to 0.825 ± 0.270 after dialysis from 0.172 ± 0.160 before dialysis, showing a positive correlation with AC/FC. Furthermore, AC/FC was observed to be significantly higher in patients who were switched to UH from LH at 3 months after the change. Conclusion: Compared with UH, LH has a lesser effect on lipid metabolism, suggesting that it also has a lesser effect on carnitine metabolism. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Prevalence of germline BRCA1/2 pathogenic variants in Japanese patients treated with castration-resistant prostate cancer and efficacy of CRPC treatment in real-world clinical practice.

Author

Maekawa, Shigekatsu, Takata, Ryo, Sekiguchi, Kie, Kagabu, Masahiro, Toyoshima, Moe, Tamada, Shinji, Takahashi, Kenta, Ikarashi, Daiki, Matsuura, Tomohiko, Kato, Renpei, Kato, Yoichiro, Kanehira, Mitsugu, Sugimura, Jun, Abe, Takaya, Baba, Tsukasa, and Obara, Wataru

Published
2024
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41. Postoperative recurrence detection using individualized circulating tumor DNA in upper tract urothelial carcinoma

Author

Tamura, Daichi, primary, Abe, Masakazu, additional, Hiraki, Hayato, additional, Sasaki, Noriyuki, additional, Yashima‐Abo, Akiko, additional, Ikarashi, Daiki, additional, Kato, Renpei, additional, Kato, Yoichiro, additional, Maekawa, Shigekatsu, additional, Kanehira, Mitsugu, additional, Takata, Ryo, additional, Maejima, Kazuhiro, additional, Sasagawa, Shota, additional, Fujita, Masashi, additional, Suzuki, Yutaka, additional, Nakagawa, Hidewaki, additional, Iwaya, Takeshi, additional, Nishizuka, Satoshi S., additional, and Obara, Wataru, additional

Published
2023
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43. TAS0313 plus Pembrolizumab for Post-Chemotherapy Immune Checkpoint Inhibitor—Naïve Locally Advanced or Metastatic Urothelial Carcinoma

Author

Nishiyama, Hiroyuki, primary, Yonese, Junji, additional, Kawahara, Takashi, additional, Matsumoto, Ryuji, additional, Miyake, Hideaki, additional, Matsubara, Nobuaki, additional, Uemura, Hiroji, additional, Eto, Masatoshi, additional, Azuma, Haruhito, additional, Obara, Wataru, additional, Terai, Akito, additional, Fukasawa, Satoshi, additional, and Suekane, Shigetaka, additional

Published
2023
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49. Association between nocturnal polyuria and 24‐h blood pressure fluctuations in males with lower urinary tract symptoms: A multicenter prospective study.

Author

Kato, Yoichiro, Akaihata, Hidenori, Takezawa, Kentaro, Maekawa, Shigekatsu, Matsuoka, Kanako, Fukuhara, Shinichiro, Kato, Renpei, Kojima, Yoshiyuki, Nonomura, Norio, and Obara, Wataru

Subjects
POLYURIA, NOCTURIA, BLOOD pressure, URINARY organs, DIASTOLIC blood pressure, SYSTOLIC blood pressure
Abstract

Objectives: Nocturnal polyuria (NP) is one of the causes of nocturia that impairs quality of life. It is necessary to consider that NP is latent when the initial treatment for nocturia is unsatisfactory. Therefore, it is important to establish a treatment for NP based on the pathophysiology. We have previously reported the relationship between NP and fluctuation in blood pressure. The present study aimed to investigate the association between NP and 24‐h blood pressure fluctuations in a multicenter prospective study. Methods: This study included male patients with lower urinary tract symptoms. We categorized the patients into the nonnocturnal polyuria (non‐NP) group (≤0.33) and the NP group (>0.33) based on the nocturnal polyuria index from the frequency volume chart. We measured the 24‐h diurnal blood pressure and compared the two groups. Results: Among 90 patients, 46 in the non‐NP group and 44 in the NP group were included. There was no significant difference in the systolic and diastolic blood pressure during waking time between the two groups; however, the degree of systolic blood pressure reduction during sleep time in the NP group was significantly less than that in the non‐NP group (p = 0.039). In the multivariate analysis, systolic BP during sleep was significantly associated with NP (OR 0.970, p = 0.028). Conclusion: NP is associated with inadequate nocturnal blood pressure reduction in males, suggesting that reduction in nocturnal blood pressure may lead to improvement in nocturia. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Postoperative recurrence detection using individualized circulating tumor DNA in upper tract urothelial carcinoma.

Author

Tamura, Daichi, Abe, Masakazu, Hiraki, Hayato, Sasaki, Noriyuki, Yashima‐Abo, Akiko, Ikarashi, Daiki, Kato, Renpei, Kato, Yoichiro, Maekawa, Shigekatsu, Kanehira, Mitsugu, Takata, Ryo, Maejima, Kazuhiro, Sasagawa, Shota, Fujita, Masashi, Suzuki, Yutaka, Nakagawa, Hidewaki, Iwaya, Takeshi, Nishizuka, Satoshi S., and Obara, Wataru

Abstract

Biomarkers that could detect the postoperative recurrence of upper tract urothelial carcinoma (UTUC) have not been established. In this prospective study, we aim to evaluate the utility of individualized circulating tumor DNA (ctDNA) monitoring using digital PCR (dPCR) as a tumor recurrence biomarker for UTUC in the perioperative period. Twenty‐three patients who underwent radical nephroureterectomy (RNU) were included. In each patient, whole exome sequencing by next‐generation sequencing and TERT promoter sequencing of tumor DNA were carried out. Case‐specific gene mutations were selected from sequencing analysis to examine ctDNA by dPCR analysis. We also prospectively collected plasma and urine ctDNA from each patient. The longitudinal variant allele frequencies of ctDNA during the perioperative period were plotted. Case‐specific gene mutations were detected in 22 cases (96%) from ctDNA in the preoperative samples. Frequently detected genes were TERT (39%), FGFR3 (26%), TP53 (22%), and HRAS (13%). In all cases, we obtained plasma and urine samples for 241 time points and undertook individualized ctDNA monitoring for 2 years after RNU. Ten patients with intravesical recurrence had case‐specific ctDNA detected in urine at the time of recurrence. The mean lead time of urinary ctDNA in intravesical recurrence was 60 days (range, 0–202 days). Two patients with distal metastasis had case‐specific ctDNA in plasma at the time of metastasis. In UTUC, tumor‐specific gene mutations can be monitored postoperatively as ctDNA in plasma and urine. Individualized ctDNA might be a minimally invasive biomarker for the early detection of postoperative recurrence. [ABSTRACT FROM AUTHOR]

Published
2024
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