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Your search keyword '"O'Rourke, Robert A."' showing total 11 results
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11 results on '"O'Rourke, Robert A."'

3. Postbariatric hypoglycemia: symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery study

Author

Berk, Paul D., Bessler, Marc, Daud, Amna, Lobdell, Harrison, IV, Mwelu, Jemela, Schrope, Beth, Ude, Akuezunkpa, Honohan, Jamie, Capasso, Michelle, Costa, Ricardo, Dakin, Greg, Ebel, Faith, Gagner, Michel, Hsieh, Jane, Pomp, Alfons, Strain, Gladys, Bowden, Rita, Chapman, William, Cundiff, Blair, Ball, Mallory, Cunningham, Emily, Dohm, Lynis, Pender, John, Pories, Walter, Barker, Jennifer, Howell, Michael, Garcia, Luis, Lancaster, Kathy, Lovaas, Erika, Mitchell, James E., Monson, Tim, Cassady, Chelsea, Coburn, Emily, Moher, Emily, Deveney, Clifford, Elder, Katherine, Greene, Stefanie, Purnell, Jonathan, O’Rourke, Robert, Sorenson, Chad, Wolfe, Bruce M., Patterson, Emma, Raum, William, VanDerWerff, Lisa, Kwiatkowski, Jason, Courcoulas, Anita P., Gourash, William, McCloskey, Carol A., Ramanathan, Ramesh, Kalarchian, Melissa, Marcus, Marsha, Shirley, Eleanor, Turo, Angela, Flum, David R., Dellinger, E. Patchen, Khandelwal, Saurabh, Stewart, Skye D., Cooley, Morgan M., Blissell, Rebecca, Miller, Megan J., Thirlby, Richard, Chang, Lily, Hunter, Jeffrey, Moonka, Ravi, Ng, Debbie, Belle, Steven H., King, Wendy C., Martin, Debbie, Mercurio, Rocco, Wahed, Abdus, Averbach, Frani, Horlick, Mary, Miles, Carolyn W., Staten, Myrlene A., Yanovski, Susan Z., Kleiner, David E., Fischer, Laura E., Fino, Nora, Elman, Miriam R., Pories, Walter J., Purnell, Jonathan Q., and Patti, Mary-Elizabeth

Published
2021
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4. Matrix density regulates adipocyte phenotype

Author

Ky, Alexander, primary, McCoy, Atticus J., additional, Flesher, Carmen G., additional, Friend, Nicole E., additional, Li, Jie, additional, Akinleye, Kore, additional, Patsalis, Christopher, additional, Lumeng, Carey N., additional, Putnam, Andrew J., additional, and O’Rourke, Robert W., additional

Published
2023
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7. Adipose METTL14‐Elicited N6‐Methyladenosine Promotes Obesity, Insulin Resistance, and NAFLD Through Suppressing β Adrenergic Signaling and Lipolysis.

Author

Kang, Qianqian, Zhu, Xiaorong, Ren, Decheng, Ky, Alexander, MacDougald, Ormond A., O'Rourke, Robert W., and Rui, Liangyou

Subjects
LIPOLYSIS, INSULIN resistance, NON-alcoholic fatty liver disease, HIGH-fat diet, WHITE adipose tissue, SYMPATHETIC nervous system
Abstract

White adipose tissue (WAT) lipolysis releases free fatty acids as a key energy substance to support metabolism in fasting, cold exposure, and exercise. Atgl, in concert with Cgi‐58, catalyzes the first lipolytic reaction. The sympathetic nervous system (SNS) stimulates lipolysis via neurotransmitter norepinephrine that activates adipocyte β adrenergic receptors (Adrb1‐3). In obesity, adipose Adrb signaling and lipolysis are impaired, contributing to pathogenic WAT expansion; however, the underling mechanism remains poorly understood. Recent studies highlight importance of N6‐methyladenosine (m6A)‐based RNA modification in health and disease. METTL14 heterodimerizes with METTL3 to form an RNA methyltransferase complex that installs m6A in transcripts. Here, this work shows that adipose Mettl3 and Mettl14 are influenced by fasting, refeeding, and insulin, and are upregulated in high fat diet (HFD) induced obesity. Adipose Adrb2, Adrb3, Atgl, and Cgi‐58 transcript m6A contents are elevated in obesity. Mettl14 ablation decreases these transcripts' m6A contents and increases their translations and protein levels in adipocytes, thereby increasing Adrb signaling and lipolysis. Mice with adipocyte‐specific deletion of Mettl14 are resistant to HFD‐induced obesity, insulin resistance, glucose intolerance, and nonalcoholic fatty liver disease (NAFLD). These results unravel a METTL14/m6A/translation pathway governing Adrb signaling and lipolysis. METTL14/m6A‐based epitranscriptomic reprogramming impairs adipose Adrb signaling and lipolysis, promoting obesity, NAFLD, and metabolic disease. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Postbariatric hypoglycemia: symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery study

Author

Fischer, Laura E., primary, Wolfe, Bruce M., additional, Fino, Nora, additional, Elman, Miriam R., additional, Flum, David R., additional, Mitchell, James E., additional, Pomp, Alfons, additional, Pories, Walter J., additional, Purnell, Jonathan Q., additional, Patti, Mary-Elizabeth, additional, Berk, Paul D., additional, Bessler, Marc, additional, Daud, Amna, additional, Lobdell, Harrison, additional, Mwelu, Jemela, additional, Schrope, Beth, additional, Ude, Akuezunkpa, additional, Honohan, Jamie, additional, Capasso, Michelle, additional, Costa, Ricardo, additional, Dakin, Greg, additional, Ebel, Faith, additional, Gagner, Michel, additional, Hsieh, Jane, additional, Strain, Gladys, additional, Bowden, Rita, additional, Chapman, William, additional, Cundiff, Blair, additional, Ball, Mallory, additional, Cunningham, Emily, additional, Dohm, Lynis, additional, Pender, John, additional, Pories, Walter, additional, Barker, Jennifer, additional, Howell, Michael, additional, Garcia, Luis, additional, Lancaster, Kathy, additional, Lovaas, Erika, additional, Monson, Tim, additional, Cassady, Chelsea, additional, Coburn, Emily, additional, Moher, Emily, additional, Deveney, Clifford, additional, Elder, Katherine, additional, Greene, Stefanie, additional, Purnell, Jonathan, additional, O’Rourke, Robert, additional, Sorenson, Chad, additional, Patterson, Emma, additional, Raum, William, additional, VanDerWerff, Lisa, additional, Kwiatkowski, Jason, additional, Courcoulas, Anita P., additional, Gourash, William, additional, McCloskey, Carol A., additional, Ramanathan, Ramesh, additional, Kalarchian, Melissa, additional, Marcus, Marsha, additional, Shirley, Eleanor, additional, Turo, Angela, additional, Dellinger, E. Patchen, additional, Khandelwal, Saurabh, additional, Stewart, Skye D., additional, Cooley, Morgan M., additional, Blissell, Rebecca, additional, Miller, Megan J., additional, Thirlby, Richard, additional, Chang, Lily, additional, Hunter, Jeffrey, additional, Moonka, Ravi, additional, Ng, Debbie, additional, Belle, Steven H., additional, King, Wendy C., additional, Martin, Debbie, additional, Mercurio, Rocco, additional, Wahed, Abdus, additional, Averbach, Frani, additional, Horlick, Mary, additional, Miles, Carolyn W., additional, Staten, Myrlene A., additional, Yanovski, Susan Z., additional, and Kleiner, David E., additional

Published
2021
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