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In this cross‐sectional study, we explored the current status and the correlates of self‐perceived transcultural self‐efficacy among nurses working in a tertiary hospital in Hangzhou, China. A total of 336 nurses (age range, 24–50 years) completed the Chinese version of the Transcultural Self‐Efficacy Tool. The majority of respondents were female (94.64%), and 67.26% were government employees. Between group differences were assessed using the rank sum test. Most nurses had a below‐moderate level of self‐perceived transcultural self‐efficacy in all subscales (Cognitive [67.69%]; Practical [71.65%], Affective [66.75%]). Age, professional title, employment type, and income level had a significant influence on all three subscale scores of the survey instrument. Our findings highlight the need for inclusion of transcultural nursing in the continuing education curricula for nurses. Nursing managers should target continuing education based on the demographic characteristics of nurses. Hospital managers should consider minimizing the pay disparity between government‐employed and temporary nurses. These initiatives can help improve the quality of nursing care in a cross‐cultural milieu. [ABSTRACT FROM AUTHOR]