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13 results on '"Noguera, Nelida"'

1. MCL1 regulates AML cells metabolism via direct interaction with HK2. Metabolic signature at onset predicts overall survival in AMLs’ patients

Author

Catalano, Gianfranco, Zaza, Alessandra, Banella, Cristina, Pelosi, Elvira, Castelli, Germana, de Marinis, Elisabetta, Smigliani, Ariela, Travaglini, Serena, Ottone, Tiziana, Divona, Mariadomenica, Del Principe, Maria Ilaria, Buccisano, Francesco, Maurillo, Luca, Ammatuna, Emanuele, Testa, Ugo, Nervi, Clara, Venditti, Adriano, Voso, Maria Teresa, and Noguera, Nelida Ines

Published
2023
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2. CD99 as a novel therapeutic target on leukemic progenitor cells in FLT3-ITDmut AML

Author

Travaglini, Serena, Ottone, Tiziana, Angelini, Daniela Francesca, Fiori, Valentina, Dominici, Sabrina, Noguera, Nelida Ines, Śniegocka, Martyna, Antonelli, Silvia, Irno Consalvo, Maria Antonietta, De Bardi, Marco, Banella, Cristina, Divona, Mariadomenica, Marchesi, Francesco, Masciarelli, Silvia, Fazi, Francesco, Pieraccioli, Marco, Palmieri, Raffaele, De Angelis, Gottardo, Buccisano, Francesco, Venditti, Adriano, Battistini, Luca, Magnani, Mauro, and Voso, Maria Teresa

Published
2022
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3. Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies.

Author

Niscola, Pasquale, Gianfelici, Valentina, Catalano, Gianfranco, Giovannini, Marco, Mazzone, Carla, Noguera, Nelida Ines, and de Fabritiis, Paolo

Subjects
STEM cell transplantation, ACUTE myeloid leukemia, OLDER patients, OLDER people, INDUCTION chemotherapy
Abstract

Acute myeloid leukemia (AML) is a heterogeneous blood-related neoplasm that predominantly afflicts older adults with a poor prognosis due to their physical condition and the presence of medical accompanying comorbidities, adverse biological disease features, and suitability for induction intensive chemotherapy and allogenic stem cells transplantation. Recent research into the molecular and biological factors contributing to disease development and progression has led to significant advancements in treatment approaches for older patients with AML. This review article discusses the latest biological and therapeutic developments that are transforming the management of AML in older adults. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Characterization of a novel IDH2‐R159H mutation in acute myeloid leukaemia: Effects on cell metabolism and differentiation

Author

Nardozza, Anna Maria, primary, Guarnera, Luca, additional, Travaglini, Serena, additional, Ottone, Tiziana, additional, Divona, Mariadomenica, additional, De Bellis, Eleonora, additional, Savi, Arianna, additional, Banella, Cristina, additional, Noguera, Nelida Ines, additional, Di Fusco, Davide, additional, Monteleone, Ivan, additional, and Voso, Maria Teresa, additional

Published
2023
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5. YY1 Knockdown Relieves the Differentiation Block and Restores Apoptosis in AML Cells

Author

Noguera, Nelida Ines, primary, Travaglini, Serena, additional, Scalea, Stefania, additional, Catalanotto, Caterina, additional, Reale, Anna, additional, Zampieri, Michele, additional, Zaza, Alessandra, additional, Ricciardi, Maria Rosaria, additional, Angelini, Daniela Francesca, additional, Tafuri, Agostino, additional, Ottone, Tiziana, additional, Voso, Maria Teresa, additional, and Zardo, Giuseppe, additional

Published
2023
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6. PB1787: PLZF-RARΑ ENHANCES METABOLIC PLASTICITY AND ROS SCAVENGING IN AML CELLS

Author

Zaza, Alessandra, primary, Gallo, Mariana, additional, Biscussi, Brunella, additional, Angelini, Daniela F., additional, Pasqualini, Gloria, additional, Catalano, Gianfranco, additional, De Marinis, Elisabetta, additional, Pertinhez, Thelma, additional, Voso, Maria Teresa, additional, Venditti, Adriano, additional, Nervi, Clara, additional, and Noguera, Nelida Ines, additional

Published
2023
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7. Characterization of a novel IDH2‐R159H mutation in acute myeloid leukaemia: Effects on cell metabolism and differentiation.

Author

Nardozza, Anna Maria, Guarnera, Luca, Travaglini, Serena, Ottone, Tiziana, Divona, Mariadomenica, De Bellis, Eleonora, Savi, Arianna, Banella, Cristina, Noguera, Nelida Ines, Di Fusco, Davide, Monteleone, Ivan, and Voso, Maria Teresa

Subjects
ACUTE myeloid leukemia, CELL metabolism, CELL differentiation, GENETIC mutation, KREBS cycle
Abstract

This article, published in the British Journal of Haematology, discusses a novel IDH2-R159H mutation found in a patient with acute myeloid leukaemia (AML). The mutation was acquired during disease progression and had a significant impact on cell metabolism and differentiation. The study also explores the sensitivity of the mutation to enasidenib, an oral inhibitor of mutant IDH2. The findings suggest that the presence of the IDH2-R159H mutation, along with another mutation, may be associated with a negative outcome and reduced response to enasidenib. The authors emphasize the importance of retesting for molecular changes during the course of the disease. [Extracted from the article]

Published
2024
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8. Effects of Triheptanoin on Mitochondrial Respiration and Glycolysis in Cultured Fibroblasts from Neutral Lipid Storage Disease Type M(NLSD-M) Patients

Author

Inés Noguera, Nelida, Tavian, Daniela, Angelini, Corrado, Cortese, Francesca, Filosto, Massimiliano, Garibaldi, Matteo, Missaglia, Sara, Smigliani, Ariela, Zaza, Alessandra, Maria Pennisi, Elena, Daniela Tavian (ORCID:0000-0003-3333-0068), Sara Missaglia (ORCID:0000-0001-6551-6698), Inés Noguera, Nelida, Tavian, Daniela, Angelini, Corrado, Cortese, Francesca, Filosto, Massimiliano, Garibaldi, Matteo, Missaglia, Sara, Smigliani, Ariela, Zaza, Alessandra, Maria Pennisi, Elena, Daniela Tavian (ORCID:0000-0003-3333-0068), and Sara Missaglia (ORCID:0000-0001-6551-6698)

Abstract

Neutral lipid storage disease type M (NLSD-M) is an ultra-rare, autosomal recessive disorder that causes severe skeletal and cardiac muscle damage and lipid accumulation in all body tissues. In this hereditary pathology, the defective action of the adipose triglyceride lipase (ATGL) enzyme induces the enlargement of cytoplasmic lipid droplets and reduction in the detachment of mono- (MG) and diglycerides (DG). Although the pathogenesis of muscle fiber necrosis is unknown, some studies have shown alterations in cellular energy production, probably because MG and DG, the substrates of Krebs cycle, are less available. No tests have been tried with medium-chain fatty acid molecules to evaluate the anaplerotic effect in NLSD cells. In this study, we evaluated the in vitro effect of triheptanoin (Dojolvi®), a highly purified chemical triglyceride with seven carbon atoms, in fibroblasts obtained from five NLSD-M patients. Glycolytic and mitochondrial functions were determined by Seahorse XF Agylent Technology, and cellular viability and triglyceride content were measured through colorimetric assays. After the addition of triheptanoin, we observed an increase in glycolysis and mitochondrial respiration in all patients compared with healthy controls. These preliminary results show that triheptanoin is able to induce an anaplerotic effect in NLSD-M fibroblasts, paving the way towards new therapeutic strategies.

Published
2023

9. Effects of Triheptanoin on Mitochondrial Respiration and Glycolysis in Cultured Fibroblasts from Neutral Lipid Storage Disease Type M (NLSD-M) Patients

Author

Noguera, Nelida Inés, primary, Tavian, Daniela, additional, Angelini, Corrado, additional, Cortese, Francesca, additional, Filosto, Massimiliano, additional, Garibaldi, Matteo, additional, Missaglia, Sara, additional, Smigliani, Ariela, additional, Zaza, Alessandra, additional, and Pennisi, Elena Maria, additional

Published
2023
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10. Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia

Author

Pereira‐Martins, Diego A., primary, Coelho‐Silva, Juan L., additional, Weinhäuser, Isabel, additional, Franca‐Neto, Pedro L., additional, Silveira, Douglas R., additional, Ortiz, César, additional, Moreira‐Aguiar, Amanda, additional, Lima, Marinus M., additional, Koury, Luisa C., additional, de Melo, Raul A., additional, Glória, Ana B., additional, Fagundes, Evandro M., additional, Lino, Bruno K., additional, Pagnano, Katia, additional, Bittencourt, Rosane, additional, Nunes, Elenaide, additional, Traina, Fabiola, additional, Figueiredo‐Pontes, Lorena, additional, Keating, Armand, additional, Tallman, Martin S., additional, Ribeiro, Raul C., additional, Dilon, Richard, additional, Ganser, Arnold, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, Valk, Peter, additional, Löwenberg, Bob, additional, Ottone, Tiziana, additional, Noguera, Nelida I., additional, Voso, Maria T., additional, Paoloni, Francesca, additional, Fazi, Paola, additional, Ammatuna, Emanuele, additional, Huls, Gerwin, additional, Schuringa, Jan Jacob, additional, Rego, Eduardo M., additional, and Lucena‐Araujo, Antonio R., additional

Published
2022
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11. Ascorbate Plus Buformin in AML: A Metabolic Targeted Treatment

Author

Banella, Cristina, primary, Catalano, Gianfranco, additional, Travaglini, Serena, additional, Pelosi, Elvira, additional, Ottone, Tiziana, additional, Zaza, Alessandra, additional, Guerrera, Gisella, additional, Angelini, Daniela Francesca, additional, Niscola, Pasquale, additional, Divona, Mariadomenica, additional, Battistini, Luca, additional, Screnci, Maria, additional, Ammatuna, Emanuele, additional, Testa, Ugo, additional, Nervi, Clara, additional, Voso, Maria Teresa, additional, and Noguera, Nelida Ines, additional

Published
2022
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13. Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia.

Author

Pereira-Martins DA, Coelho-Silva JL, Weinhäuser I, Franca-Neto PL, Silveira DR, Ortiz C, Moreira-Aguiar A, Lima MM, Koury LC, de Melo RA, Glória AB, Fagundes EM, Lino BK, Pagnano K, Bittencourt R, Nunes E, Traina F, Figueiredo-Pontes L, Keating A, Tallman MS, Ribeiro RC, Dilon R, Ganser A, Sanz MA, Berliner N, Valk P, Löwenberg B, Ottone T, Noguera NI, Voso MT, Paoloni F, Fazi P, Ammatuna E, Huls G, Schuringa JJ, Rego EM, and Lucena-Araujo AR

Subjects
Humans, Tretinoin therapeutic use, DNA, Mitochondrial genetics, Clinical Relevance, Neoplasm Recurrence, Local drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Treatment Outcome, Leukemia, Promyelocytic, Acute drug therapy, Leukemia, Promyelocytic, Acute genetics
Abstract

Although a growing body of evidence demonstrates that altered mtDNA content (mtDNAc) has clinical implications in several types of solid tumours, its prognostic relevance in acute promyelocytic leukaemia (APL) patients remains largely unknown. Here, we show that patients with higher-than-normal mtDNAc had better outcomes regardless of tumour burden. These results were more evident in patients with low-risk of relapse. The multivariate Cox proportional hazard model demonstrated that high mtDNAc was independently associated with a decreased cumulative incidence of relapse. Altogether, our data highlights the possible role of mitochondrial metabolism in APL patients treated with ATRA., (© 2022 British Society for Haematology and John Wiley & Sons Ltd.)

Published
2023
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