Search

Janus structure offers materials unique functionalities which are difficult to achieve otherwise with isotropic counterpart, opening up new avenues in diverse application fields. Here, a series of novel photonic Janus carbon fibers (PJCFs) with structural color gradient and excellent mechanical stability are reported by introducing 1D photonic layers with a gradient of periodicity. By virtue of the unique photonic architecture, the PJCFs exhibit a multiple and continuous variation of structural color (i.e., structural color gradient) in a full spectrum. By controlling the thickness of periodic layer, a series of PJCFs with vivid and tunable structural colors ranging from blue, green, orange, to violet‐red can be obtained. Furthermore, their gradient structural colors remain constant after reciprocating rubbing and laundering, showing outstanding mechanical robustness. Notably, benefiting from the inherent electrothermal property and flexibility of CFs, the PJCFs display stable Joule heating performance even under deformation. As proof‐of‐concept, the PJCFs are further integrated with wireless transmission system to construct a multicolored, wirelessly controlled thermal management device, realizing remote and precise temperature manipulation via Bluetooth. This work provides not only a new platform for achieving distinct structural color gradient of CFs, but also a promising strategy toward next‐generation multicolored personal healthcare devices. [ABSTRACT FROM AUTHOR]

The stimuli-responsive textiles, especially water-responsive textiles, have garnered attention owing to their environmental compatibility. Inspired by the hydrochromic behavior of Diphylleia grayi , water-rewritable structural color (WRSC) textiles exhibiting fast response speed and antispreading capability were fabricated by spraying hollow SiO 2 (H-SiO 2 ) microspheres and poly(trifluoroethyl methacrylate-butyl acrylate) [P(TFEMA-BA)]. The water-written textiles exhibited structural color changes in 0.6 s via an increase in the refractive index, driven by water penetrating the gaps between H-SiO 2 microspheres. The structural color was restored to the initial state after the water evaporated, allowing multiple cycles of the write-erase-write mode. The hydrophobic P(TFEMA-BA) adhesive was used to construct a stable chromogenic array and endow WRSC textiles with antispreading properties, thereby improving structural stability and achieving clear writing patterns. The prepared WRSC textiles demonstrated high flexibility, structural stability, and water-rewritable properties, providing advanced bionic inspiration and valuable design ideas for rewritable materials and smart textiles.

Background: Disheveled, EGL-10, and pleckstrin (DEP) domain-containing protein 5 (DEPDC5) is a component of GTPase-activating protein (GAP) activity toward the RAG complex 1 (GATOR1) protein, which is an inhibitor of the amino acid-sensing branch of the mammalian target of rapamycin complex 1 (mTORC1) pathway. GATOR1 complex variations were reported to correlate with familial focal epilepsy with variable foci (FFEVF). With the wide application of whole exome sequencing (WES), more and more variations in DEPDC5 were uncovered in FFEVF families., Methods: A family with a proband diagnosed with familial focal epilepsy with variable foci (FFEVF) was involved in this study. Whole exome sequencing (WES) was performed in the proband, and Sanger sequencing was used to confirm the variation carrying status of the family members. Mini-gene splicing assay was performed to validate the effect on the alternative splicing of the variation., Results: A novel variant, c.1217 + 2T>A, in DEPDC5 was identified by WES in the proband. This splicing variant that occurred at the 5' end of intron 17 was confirmed by mini-gene splicing assays, which impacted alternative splicing and led to the inclusion of an intron fragment. The analysis of the transcribed mRNA sequence indicates that the translation of the protein is terminated prematurely, which is very likely to result in the loss of function of the protein and lead to the occurrence of FFEVF., Conclusion: The results suggest that c.1217 + 2T>A variations in DEPDC5 might be the genetic etiology for FFEVF in this pedigree. This finding expands the genotype spectrum of FFEVF and provides new etiological information for FFEVF., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wang, Niu, Shi, Bao, Liu, Lu and Sun.)

Objective: To carry out preimplantation genetic testing (PGT) for a couple where the husband was affected by osteogenesis imperfecta combined with balanced translocation using the karyomapping technique., Methods: Blastocysts were detected using karyomapping, the carrier status of COL1A1 c.760G>A (p.Gly254Arg) variant and the carrier status of the translocated chromosome were analyzed simultaneously., Results: For a total of 10 blastocysts, two euploid blastocysts were found to not carry the COL1A1 c.760G>A (p.Gly254Arg) variant but a balanced translocation. After transplanting one of the blastocysts, clinical pregnancy was achieved. Amniocentesis at 18th gestational week and prenatal genetic testing was in keeping with the result of PGT.A healthy female was born at 40+4 weeks gestation., Conclusion: For patients simultaneously carrying genetic variant and balanced chromosomal translocation, PGT can be performed with efficiency by the use of karyomapping method.