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Your search keyword '"Nicolazzo, Chiara"' showing total 17 results
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17 results on '"Nicolazzo, Chiara"'

2. An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile

Author

De Angelis, Maria Laura, Francescangeli, Federica, Nicolazzo, Chiara, Signore, Michele, Giuliani, Alessandro, Colace, Lidia, Boe, Alessandra, Magri, Valentina, Baiocchi, Marta, Ciardi, Antonio, Scarola, Francesco, Spada, Massimo, La Torre, Filippo, Gazzaniga, Paola, Biffoni, Mauro, De Maria, Ruggero, and Zeuner, Ann

Published
2022
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3. Blood Extracellular Vesicles Beyond Circulating Tumour Cells: A Valuable Risk Stratification Biomarker in High-Risk Non-Muscle-Invasive Bladder Cancer Patients.

Author

Magri, Valentina, Marino, Luca, Del Giudice, Francesco, De Meo, Michela, Siringo, Marco, De Berardinis, Ettore, Gandini, Orietta, Santini, Daniele, Nicolazzo, Chiara, and Gazzaniga, Paola

Subjects
NON-muscle invasive bladder cancer, TRANSURETHRAL resection of bladder, EXTRACELLULAR vesicles, SURVIVAL rate, PROGNOSIS
Abstract

Non-muscle-invasive bladder cancer (NMIBC) prognosis varies significantly due to the biological and clinical heterogeneity. High-risk stage T1-G3, comprising 15–20% of NMIBCs, involves the lamina propria and is associated with higher rates of recurrence, progression, and cancer-specific mortality. In the present study, we have evaluated the enumeration of tumour-derived extracellular vesicles (tdEVs) and circulating tumour cells (CTCs) in high-risk NMIBC patients and their correlation with survival outcomes such as time to progression (TTP), and cancer-specific survival (CSS). Eighty-three high-risk T1-G3 NMIBC patients treated between September 2010 and January 2013 were included. Blood samples were collected before a transurethral resection of the bladder (TURB) and analysed using the CellSearch® system. The presence of at least one CTC was associated with a shorter TTP and CSS. Extending follow-up to 120 months and incorporating automated tdEV evaluation using ACCEPT software demonstrated that tdEV count may additionally stratify patient risk. Combining tdEVs and CTCs improves risk stratification for NMIBC progression, suggesting that tdEVs could be valuable biomarkers for prognosis and disease monitoring. Further research is needed to confirm these findings and establish the clinical significance of tdEVs in early-stage cancers. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Circulating Cancer-Associated Macrophage-like Cells as a Blood-Based Biomarker of Response to Immune Checkpoint Inhibitors

Author

Magri, Valentina, primary, De Renzi, Gianluigi, additional, Marino, Luca, additional, De Meo, Michela, additional, Siringo, Marco, additional, Gelibter, Alain, additional, Gareri, Roberta, additional, Cataldi, Chiara, additional, Giannini, Giuseppe, additional, Santini, Daniele, additional, Nicolazzo, Chiara, additional, and Gazzaniga, Paola, additional

Published
2024
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8. Genomic landscape and survival analysis of ctDNA “neo-RAS wild-type” patients with originally RAS mutant metastatic colorectal cancer

Author

Nicolazzo, Chiara, primary, Magri, Valentina, additional, Marino, Luca, additional, Belardinilli, Francesca, additional, Di Nicolantonio, Federica, additional, De Renzi, Gianluigi, additional, Caponnetto, Salvatore, additional, De Meo, Michela, additional, Giannini, Giuseppe, additional, Santini, Daniele, additional, Cortesi, Enrico, additional, and Gazzaniga, Paola, additional

Published
2023
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9. An Orthotopic Patient-Derived Xenograft (PDX) Model Allows the Analysis of Metastasis-Associated Features in Colorectal Cancer

Author

De Angelis, Maria Laura, primary, Francescangeli, Federica, additional, Nicolazzo, Chiara, additional, Xhelili, Eljona, additional, La Torre, Filippo, additional, Colace, Lidia, additional, Bruselles, Alessandro, additional, Macchia, Daniele, additional, Vitale, Sara, additional, Gazzaniga, Paola, additional, Baiocchi, Marta, additional, and Zeuner, Ann, additional

Published
2022
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11. Additional file 1 of An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile

Author

De Angelis, Maria Laura, Francescangeli, Federica, Nicolazzo, Chiara, Signore, Michele, Giuliani, Alessandro, Colace, Lidia, Boe, Alessandra, Magri, Valentina, Baiocchi, Marta, Ciardi, Antonio, Scarola, Francesco, Spada, Massimo, La Torre, Filippo, Gazzaniga, Paola, Biffoni, Mauro, De Maria, Ruggero, and Zeuner, Ann

Abstract

Additional file 1:. Supplementary Methods.

Published
2022
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12. RAS Mutation Conversion in Bevacizumab-Treated Metastatic Colorectal Cancer Patients: A Liquid Biopsy Based Study

Author

Nicolazzo, Chiara, primary, Belardinilli, Francesca, additional, Vestri, Annarita, additional, Magri, Valentina, additional, De Renzi, Gianluigi, additional, De Meo, Michela, additional, Caponnetto, Salvatore, additional, Di Nicolantonio, Federica, additional, Cortesi, Enrico, additional, Giannini, Giuseppe, additional, and Gazzaniga, Paola, additional

Published
2022
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15. Comparison of Two Blood-Based Genotyping Tests to Investigate the KRAS G12C Mutation in Patients with Non-Small-Cell Lung Cancer at Failure of First-Line Treatments

Author

Nicolazzo, Chiara, primary, Gelibter, Alain, additional, Bottillo, Irene, additional, Belardinilli, Francesca, additional, Pisegna, Simona, additional, De Renzi, Gianluigi, additional, Marinelli, Daniele, additional, Grammatico, Paola, additional, Cortesi, Enrico, additional, Giannini, Giuseppe, additional, and Gazzaniga, Paola, additional

Published
2021
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16. A Fast and Furious Liquid Biopsy Assay to Monitor Targeted Therapy Resistance.

Author

Nicolazzo C and Gazzaniga P

Subjects
Biomarkers, Tumor genetics, Drug Resistance, Neoplasm genetics, Humans, Liquid Biopsy methods, Circulating Tumor DNA genetics, Neoplastic Cells, Circulating pathology
Abstract

Liquid biopsies represent a valid alternative to conventional tissue biopsies, offering a real time molecular picture of tumors in a minimally invasive manner. Of the various circulating biomarkers available for liquid biopsy, circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) are the most intensively studied to date. However, CTC and ctDNA represent different tumor components, therefore, complementary information from both sources might be beneficial. This protocol focuses on the description of a sample processing workflow that allowed for concurrent isolation of CTC and ctDNA from the same source sample. This single tube approach enables simultaneous analysis of multiple biomarkers to better monitor cancer drug resistance., (© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2022
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