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Dendrimers are symmetric molecules; their size is within the nanoscale. Its structure is usually homogeneous and monodisperse; they are composed of a nucleus and several layers. The number of layers that the dendrimer has defines its generation. There are different types of dendrimers. The synthesis of these macromolecules is carried out following steps of growth and activation, and organic reactions are required to obtain their branched structure. Although size is essential, the determining factor of toxicity in dendrimers is the charge of the surface; it has been found that the higher generation dendrimers and the cationic ones are the most toxic compared to the lower generation anionics that evaluated at low concentrations did not show any toxicity. The dendrimers will favor the pharmacokinetics of a drug through the dendritic structure, the generation of the dendrimer to be used, the intramolecular interaction force between the adjacent functional groups in the dendrimer, the conditions of the environment such as pH, solvent polarity, strength ionic, saline concentration or presence of counterions, among others 4. Due to dendrimers' size and surface composition, the use of dendrimers in drug delivery has been increasingly studied. There are different interaction mechanisms between drugs in dendrimers, and these can be broadly divided into simple encapsulation, electrostatic interaction, and covalent bonds 5. The use of dendrimers in ocular administration has greatly impacted the complexity of this administration route. Gene therapy has also benefited from the emergence of these molecules as it facilitates targeted therapy. [ABSTRACT FROM AUTHOR]

Workshops using arts and board games are forms of non-pharmacological intervention widely employed in seniors with neurocognitive disorders. However, clear guidelines on how to conduct these workshops are missing. The objective of the Art and Game project (AGAP) was to draft recommendations on the structure and content of workshops for elderly people with neurocognitive disorders and healthy seniors, with a particular focus on remote/hybrid workshops, in which at least a part of the participants is connected remotely. Recommendations were gathered using a Delphi methodology. The expert panel (N = 18) included experts in the health, art and/or board games domains. They answered questions via two rounds of web-surveys, and then discussed the results in a plenary meeting. Some of the questions were also shared with the general public (N = 101). Both the experts and the general public suggested that organizing workshops in a hybrid format (some face-to-face sessions, some virtual session) is feasible and interesting for people with neurocognitive disorders. We reported guidelines on the overall structure of workshops, practical tips on how to organize remote workshops, and a SWOT analysis of the use of remote/hybrid workshops. The guidelines may be employed by clinicians to decide, based on their needs and constraints, what interventions and what kind of workshop format to employ, as well as by researcher to standardize procedures to assess the effectiveness of non-pharmacological treatments for people with neurocognitive disorders.