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2. Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial

Author

Wang, Yongjun, Wang, Yilong, Liu, Liping, Liebeskind, David S., Miao, Zhongrong, Ren, Zeguang, Pereira, Vitor Mendes, Ji, Xunming, Dong, Qiang, Xu, Anding, Liu, Xinfeng, Yang, Qingwu, Jing (Chair), Jing, Zhang, Zhe, Zhang, Yingkui, Wu, Wei, Sun, Dapeng, Qi, Zhongqi, Li, Shuo, Liu, Zhenqiang, Yu, Zequan, Zhang, Jingyu, Chen, Fangguang, Li, Kangyue, Zhang, Kai, Hu, Mingkai, Liu (Chair), Jianmin, Yao, Chen, Chen, Kangning, Fang (Chair), Kun, Song, Bo, Dong, Yi, Huo, Xiaochuan, Ma, Gaoting, Yuan, Guangxiong, Han, Hongxing, Chen, Wenhuo, Wei, Ming, Zhang, Jiangang, Zhou, Zhiming, Yao, Xiaoxi, Wang, Guoqing, Song, Weigen, Cai, Xueli, Nan, Guangxian, Li, Di, Wang, Yizhou, Ling, Wentong, Cai, Chuwei, Wen, Changming, Wang, En, Zhang, Liyong, Jiang, Changchun, Liu, Yajie, Liao, Geng, Chen, Xiaohui, Li, Tianxiao, Liu, Shudong, Li, Jinglun, Sun, Yaxuan, Xu, Na, Gao, Zong’en, Ju, Dongsheng, Song, Cunfeng, Xuan, Jinggang, Zhou, Feng, Shi, Qing, Luo, Jun, Liu, Yan, Guo, Zaiyu, Li, Tong, Zheng, Hongbo, Dai, Linzhi, Zhao, Junfeng, Gui, Liqiang, Geng, Xiaokun, Tang, Yufeng, Yin, Congguo, Yang, Hua, An, Ruiyang, Sun, Yuying, Wu, Yanan, Yu, Chunlai, Zheng, Shuangcheng, Pan, Yuesong, Jin, Aoming, Xiang, Xianglong, Wang, Mengxing, Yan, Hongyi, He, Yuanling, Li, Chunyang, Kong, Weixia, Chen, Yuhuan, Guo, Chenhao, Ji, Fengjie, Ji, Pengshan, Liu, Lei, Lu, Xinghua, Luo, Guangkuo, Wang, Nanjing, Zhang, Yu, Liu, Bo, Yang, Jian, Deng, Jingjing, Wang, Juan, Wang, Wanru, Yu, Hang, Cui, Le, Liu, Wenwen, Wang, Ziyong, Zhao, Xia, Zhou, Zhou, Yi-Chou Wang, Alvin, Zheng, Lina, Nie, Ximing, Liu, Xin, Duan, Wanying, Liu, Jingyi, Wei, Yufei, Wen, Miao, Yang, Zhonghua, Leung, Thomas W., Nguyen, Thanh N., and Leng, Xinyi

Published
2024
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3. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials

Author

Zi, Wenjie, Nogueira, Raul, Yang, Qingwu, Liu, Jianmin, Yang, Pengfei, Zhang, Yongwei, Yan, Bernard, Mitchell, Peter, Miao, Zhong Rong, Majoie, Charles B., Roos, Yvo B., Suzuki, Kentaro, Kimura, Kazumi, Matsumaru, Yuji, Fischer, Urs, Gralla, Jan, Cavalcante, Fabiano W., Kappelhof, Manon, Treurniet, Kilian M., Kaesmacher, Johannes, Zhang, Lei, Bush, Steven, Nieboer, Daan, Lingsma, Hester F., Rothwell, Peter, Saver, Jeffrey, Fiehler, Jens, Li, Fengli, Huang, Jiacheng, Song, Jiaxing, Hong, Bo, Chen, Wenhuo, Peng, Ya, Han, Hongxing, Zhang, Liyong, Li, Zifu, Xing, Pengfei, Shen, Hongjian, Zhang, Ping, Zhang, Xiaoxi, Davis, Stephen, Nguyen, Huy-Thang, Donnan, Geoffrey, Huo, Xiaochuan, Nan, Guangxian, Bivard, Andrew, Ma, Henry, Vu, Dang Lu, Campbell, Bruce, Rinkel, Leon A., Emmer, Bart J., Coutinho, Jonathan M., LeCouffe, Natalie E., Dippel, Diederik W., van der Lugt, Aad, van Zwam, Wim H., van Oostenbrugge, Robert J., Uyttenboogaart, Maarten, Costalat, Vincent, Lycklama, Geert, Hofmeijer, Jeannette, van Norden, Anouk, Otsuka, Toshiaki, Takeuchi, Masataka, Morimoto, Masafumi, Kanazawa, Ryuzaburo, Takayama, Yohei, Kamiya, Yuki, Shigeta, Keigo, Okubo, Seiji, Hayakawa, Mikito, Strbian, Daniel, Eker, Omer, Cognard, Christophe, Meinel, Thomas, Dobrocky, Tomas, Jung, Simon, Piechowiak, Eike, Marnat, Gaultier, Sibon, Igor, Bourcier, Romain, de Gaalon, Solene, Papagiannaki, Chrysanthi, Lefebvre, Margaux, Majoie, Charles B, Cavalcante, Fabiano, Treurniet, Kilian M, Miao, Zhongrong, Rinkel, Leon A, Wang, Shouchun, Coutinho, Jonathan M, Emmer, Bart J, LeCouffe, Natalie E, Lingsma, Hester F, Nogueira, Raul G, and Roos, Yvo B

Published
2023
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4. Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial

Author

Zheng, Lina, primary, Nie, Ximing, additional, Wang, Mengxing, additional, Liu, Xin, additional, Duan, Wanying, additional, Zhang, Zhe, additional, Liu, Jingyi, additional, Wei, Yufei, additional, Wen, Miao, additional, Yang, Zhonghua, additional, Leung, Thomas W., additional, Ma, Gaoting, additional, Huo, Xiaochuan, additional, Pan, Yuesong, additional, Nguyen, Thanh N., additional, Leng, Xinyi, additional, Miao, Zhongrong, additional, Liu, Liping, additional, Wang, Yongjun, additional, Wang, Yilong, additional, Liebeskind, David S., additional, Ren, Zeguang, additional, Pereira, Vitor Mendes, additional, Ji, Xunming, additional, Dong, Qiang, additional, Xu, Anding, additional, Liu, Xinfeng, additional, Yang, Qingwu, additional, Jing (Chair), Jing, additional, Zhang, Yingkui, additional, Wu, Wei, additional, Sun, Dapeng, additional, Qi, Zhongqi, additional, Li, Shuo, additional, Liu, Zhenqiang, additional, Yu, Zequan, additional, Zhang, Jingyu, additional, Chen, Fangguang, additional, Li, Kangyue, additional, Zhang, Kai, additional, Hu, Mingkai, additional, Liu (Chair), Jianmin, additional, Yao, Chen, additional, Chen, Kangning, additional, Fang (Chair), Kun, additional, Song, Bo, additional, Dong, Yi, additional, Yuan, Guangxiong, additional, Han, Hongxing, additional, Chen, Wenhuo, additional, Wei, Ming, additional, Zhang, Jiangang, additional, Zhou, Zhiming, additional, Yao, Xiaoxi, additional, Wang, Guoqing, additional, Song, Weigen, additional, Cai, Xueli, additional, Nan, Guangxian, additional, Li, Di, additional, Wang, Yizhou, additional, Ling, Wentong, additional, Cai, Chuwei, additional, Wen, Changming, additional, Wang, En, additional, Zhang, Liyong, additional, Jiang, Changchun, additional, Liu, Yajie, additional, Liao, Geng, additional, Chen, Xiaohui, additional, Li, Tianxiao, additional, Liu, Shudong, additional, Li, Jinglun, additional, Sun, Yaxuan, additional, Xu, Na, additional, Gao, Zong’en, additional, Ju, Dongsheng, additional, Song, Cunfeng, additional, Xuan, Jinggang, additional, Zhou, Feng, additional, Shi, Qing, additional, Luo, Jun, additional, Liu, Yan, additional, Guo, Zaiyu, additional, Li, Tong, additional, Zheng, Hongbo, additional, Dai, Linzhi, additional, Zhao, Junfeng, additional, Gui, Liqiang, additional, Geng, Xiaokun, additional, Tang, Yufeng, additional, Yin, Congguo, additional, Yang, Hua, additional, An, Ruiyang, additional, Sun, Yuying, additional, Wu, Yanan, additional, Yu, Chunlai, additional, Zheng, Shuangcheng, additional, Jin, Aoming, additional, Xiang, Xianglong, additional, Yan, Hongyi, additional, He, Yuanling, additional, Li, Chunyang, additional, Kong, Weixia, additional, Chen, Yuhuan, additional, Guo, Chenhao, additional, Ji, Fengjie, additional, Ji, Pengshan, additional, Liu, Lei, additional, Lu, Xinghua, additional, Luo, Guangkuo, additional, Wang, Nanjing, additional, Zhang, Yu, additional, Liu, Bo, additional, Yang, Jian, additional, Deng, Jingjing, additional, Wang, Juan, additional, Wang, Wanru, additional, Yu, Hang, additional, Cui, Le, additional, Liu, Wenwen, additional, Wang, Ziyong, additional, Zhao, Xia, additional, Zhou, Zhou, additional, and Yi-Chou Wang, Alvin, additional

Published
2024
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5. Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial

Author

Yang, Pengfei, Song, Lili, Zhang, Yongwei, Zhang, Xiaoxi, Chen, Xiaoying, Li, Yunke, Sun, Lingli, Wan, Yingfeng, Billot, Laurent, Li, Qiang, Ren, Xinwen, Shen, Hongjian, Zhang, Lei, Li, Zifu, Xing, Pengfei, Zhang, Yongxin, Zhang, Ping, Hua, Weilong, Shen, Fang, Zhou, Yihan, Tian, Bing, Chen, Wenhuo, Han, Hongxing, Zhang, Liyong, Xu, Chenghua, Li, Tong, Peng, Ya, Yue, Xincan, Chen, Shengli, Wen, Changming, Wan, Shu, Yin, Congguo, Wei, Ming, Shu, Hansheng, Nan, Guangxian, Liu, Sheng, Liu, Wenhua, Cai, Yiling, Sui, Yi, Chen, Maohua, Zhou, Yu, Zuo, Qiao, Dai, Dongwei, Zhao, Rui, Huang, Qinghai, Xu, Yi, Deng, Benqiang, Wu, Tao, Lu, Jianping, Wang, Xia, Parsons, Mark W, Butcher, Ken, Campbell, Bruce, Robinson, Thompson G, Goyal, Mayank, Dippel, Diederik, Roos, Yvo, Majoie, Charles, Wang, Longde, Wang, Yongjun, Liu, Jianmin, and Anderson, Craig S

Published
2022
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6. Aphasia due to right hemisphere infarction in a patient with situs inversus after carotid artery stenting: a case report.

Author

Zhao, Jingmin, Shen, Guangxun, Nan, Guangxian, and Zhao, Songji

Subjects
CEREBRAL dominance, SITUS inversus, MAGNETIC resonance imaging, DOMINANT language, PARIETAL lobe, CEREBRAL infarction
Abstract

Background: Situs inversus (SI) is a rare congenital anomaly in which systemic organs and vessels are positioned in a mirror image of their normal positions. An interesting issue regarding individuals with such a condition is whether they also have reversed brain asymmetries. Most of studies on this issue indicate that, similarly to many people with normal visceral alignment, patients with SI have a left hemispheric dominance for language functions. Case presentation: We report a rare occurrence of anomalous cerebral dominance for language in a patient with complete situs inversus. The right-handed patient developed aphasia after carotid stenting, and brain magnetic resonance imaging showed cerebral infarction in the right parietal lobe. Conclusion: Anomalous cerebral dominance for language and visceral situs inversus in our patient both may result from a single, genetically coded atypicality of developmental gradient. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Bow hunter's syndrome due to an anomalous right vertebral artery origin and contralateral absence: a case report and literature review.

Author

Zhang, Li, Gao, Yu, Yu, Xiao, Guo, Ying, Piao, Zhe, and Nan, Guangxian

Subjects
VERTEBRAL artery, LITERATURE reviews, BOWHUNTERS, CAROTID artery stenosis, DIGITAL subtraction angiography
Abstract

Background: Bow Hunter's syndrome (BHS), also known as rotational vertebral artery occlusion (RVAO), is a rare condition characterized by dynamic vertebrobasilar insufficiency due to position-dependent occlusion of the vertebral artery (VA). In the existing literature, most cases of BHS are attributed to osteophytic compression originating from the occipital condyle or within the transverse foramen, often accompanied by anatomical abnormalities of the VA. However, cases presenting solely with VA anomalies in the absence of any cervical vertebral structural abnormality are rare. This case report presents a unique instance of BHS in a 56-year-old male, attributed to the anomalous origin of the right VA and the absence of the left VA, without cervical structural abnormalities. Case presentation: The patient exhibited symptoms like episodic dizziness and vertigo, which were exacerbated by rightward head rotation and alleviated upon returning to a neutral position. Diagnostic evaluation, including digital subtraction angiography, revealed that the right VA originated from the right common carotid artery and compression-induced stenosis of the right VA during head rotation. Conservative management, including avoidance of certain head movements and anti-arteriosclerosis medication, led to symptom resolution over a two-year follow-up period. Conclusions: This report contributes to the understanding of BHS by highlighting a rare vascular anomaly presentation and incorporates a review of 14 similar case reports in the literature describing that an anatomical abnormality of the VA is mainly responsible for the pathology of BHS in the absence of cervical vertebral anomalies, thus emphasizing the need for careful diagnostic and management strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials

Author

Majoie, Charles B, primary, Cavalcante, Fabiano, additional, Gralla, Jan, additional, Yang, Pengfei, additional, Kaesmacher, Johannes, additional, Treurniet, Kilian M, additional, Kappelhof, Manon, additional, Yan, Bernard, additional, Suzuki, Kentaro, additional, Zhang, Yongwei, additional, Li, Fengli, additional, Morimoto, Masafumi, additional, Zhang, Lei, additional, Miao, Zhongrong, additional, Rinkel, Leon A, additional, Huang, Jiacheng, additional, Otsuka, Toshiaki, additional, Wang, Shouchun, additional, Davis, Stephen, additional, Cognard, Christophe, additional, Hong, Bo, additional, Coutinho, Jonathan M, additional, Song, Jiaxing, additional, Chen, Wenhuo, additional, Emmer, Bart J, additional, Eker, Omer, additional, Zhang, Liyong, additional, Dobrocky, Tomas, additional, Nguyen, Huy-Thang, additional, Bush, Steven, additional, Peng, Ya, additional, LeCouffe, Natalie E, additional, Takeuchi, Masataka, additional, Han, Hongxing, additional, Matsumaru, Yuji, additional, Strbian, Daniel, additional, Lingsma, Hester F, additional, Nieboer, Daan, additional, Yang, Qingwu, additional, Meinel, Thomas, additional, Mitchell, Peter, additional, Kimura, Kazumi, additional, Zi, Wenjie, additional, Nogueira, Raul G, additional, Liu, Jianmin, additional, Roos, Yvo B, additional, Fischer, Urs, additional, Nogueira, Raul, additional, Miao, Zhong Rong, additional, Majoie, Charles B., additional, Roos, Yvo B., additional, Cavalcante, Fabiano W., additional, Treurniet, Kilian M., additional, Lingsma, Hester F., additional, Rothwell, Peter, additional, Saver, Jeffrey, additional, Fiehler, Jens, additional, Li, Zifu, additional, Xing, Pengfei, additional, Shen, Hongjian, additional, Zhang, Ping, additional, Zhang, Xiaoxi, additional, Donnan, Geoffrey, additional, Huo, Xiaochuan, additional, Nan, Guangxian, additional, Bivard, Andrew, additional, Ma, Henry, additional, Vu, Dang Lu, additional, Campbell, Bruce, additional, Rinkel, Leon A., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, LeCouffe, Natalie E., additional, Dippel, Diederik W., additional, van der Lugt, Aad, additional, van Zwam, Wim H., additional, van Oostenbrugge, Robert J., additional, Uyttenboogaart, Maarten, additional, Costalat, Vincent, additional, Lycklama, Geert, additional, Hofmeijer, Jeannette, additional, van Norden, Anouk, additional, Kanazawa, Ryuzaburo, additional, Takayama, Yohei, additional, Kamiya, Yuki, additional, Shigeta, Keigo, additional, Okubo, Seiji, additional, Hayakawa, Mikito, additional, Jung, Simon, additional, Piechowiak, Eike, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Bourcier, Romain, additional, de Gaalon, Solene, additional, Papagiannaki, Chrysanthi, additional, and Lefebvre, Margaux, additional

Published
2023
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13. Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct

Author

Huo, Xiaochuan, primary, Ma, Gaoting, additional, Tong, Xu, additional, Zhang, Xuelei, additional, Pan, Yuesong, additional, Nguyen, Thanh N., additional, Yuan, Guangxiong, additional, Han, Hongxing, additional, Chen, Wenhuo, additional, Wei, Ming, additional, Zhang, Jiangang, additional, Zhou, Zhiming, additional, Yao, Xiaoxi, additional, Wang, Guoqing, additional, Song, Weigen, additional, Cai, Xueli, additional, Nan, Guangxian, additional, Li, Di, additional, Wang, A. Yi-Chou, additional, Ling, Wentong, additional, Cai, Chuwei, additional, Wen, Changming, additional, Wang, En, additional, Zhang, Liyong, additional, Jiang, Changchun, additional, Liu, Yajie, additional, Liao, Geng, additional, Chen, Xiaohui, additional, Li, Tianxiao, additional, Liu, Shudong, additional, Li, Jinglun, additional, Gao, Feng, additional, Ma, Ning, additional, Mo, Dapeng, additional, Song, Ligang, additional, Sun, Xuan, additional, Li, Xiaoqing, additional, Deng, Yiming, additional, Luo, Gang, additional, Lv, Ming, additional, He, Hongwei, additional, Liu, Aihua, additional, Zhang, Jingbo, additional, Mu, Shiqing, additional, Liu, Lian, additional, Jing, Jing, additional, Nie, Ximing, additional, Ding, Zeyu, additional, Du, Wanliang, additional, Zhao, Xingquan, additional, Yang, Pengfei, additional, Liu, Liping, additional, Wang, Yilong, additional, Liebeskind, David S., additional, Pereira, Vitor M., additional, Ren, Zeguang, additional, Wang, Yongjun, additional, and Miao, Zhongrong, additional

Published
2023
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14. Cerebral stroke mimics associated with spinal vascular disease: two case reports

Author

Li, Huiying and Nan, Guangxian

Subjects
Case Report
Abstract

Several diseases produce symptoms similar to those of a cerebral stroke, resulting in their misdiagnosis as stroke. Cerebral stroke mimics are common in emergency rooms. We report two cases of cerebral stroke mimics to attract the attention of clinicians, especially emergency room doctors. In one case, a patient with spontaneous spinal epidural hematoma (SSEH) exhibited lower-right limb numbness and weakness. In the other, a patient with spinal cord infarction (SCI) had numbness and weakness of the lower-left limb. Both cases were misdiagnosed as cerebral strokes in the emergency room. One of the patients underwent hematoma removal surgery, and the other received medical treatment for spinal cord infarction. Patients’ symptoms improved, but the sequelae remained. Single-limb numbness and weakness are an uncommon initial presentation of spinal vascular disease that can lead to its misdiagnosis. When encountering single-limb numbness and weakness, it is necessary to consider the differential diagnosis of spinal vascular disease, thereby reducing misdiagnosis.

Published
2023

19. Comparing the efficacy and safety of the Skyflow device with those of the Solitaire FR stent in patients with acute ischemic stroke: a prospective, multicenter, randomized, non-inferiority clinical trial

Author

Zhou, Tengfei, primary, Li, Tianxiao, additional, Zhu, Liangfu, additional, Li, Zhaoshuo, additional, Li, Qiang, additional, Bai, Wei-xing, additional, He, Ying-kun, additional, Liu, Xiao, additional, Guan, Haitao, additional, Long, Youming, additional, Liu, Jinchao, additional, Wei, Liping, additional, Nan, Guangxian, additional, Li, Hongzhuang, additional, Wen, Changming, additional, Zhang, Yude, additional, Qiao, Hongyu, additional, Han, Jianfeng, additional, Wang, Shouchun, additional, Gu, Jianping, additional, Cai, Xueli, additional, Liu, Sheng, additional, and Zhao, Zhenxin, additional

Published
2021
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20. Features of myocardial injury detected by cardiac magnetic resonance in a patient with desmin‐related restrictive cardiomyopathy

Author

Chen, Zixian, primary, Li, Rui, additional, Wang, Yongxiang, additional, Cao, Liang, additional, Lin, Chen, additional, Liu, Feng, additional, Hu, Rui, additional, Nan, Jiang, additional, Zhuang, Xin, additional, Lu, Xiande, additional, Nan, Guangxian, additional, Hu, Guocui, additional, Xue, Jingmei, additional, Zhang, Yaping, additional, Xiao, Jing, additional, Yao, Yali, additional, Guo, Shunlin, additional, and Lei, Junqiang, additional

Published
2021
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21. Selection criteria for large core trials: rationale for the ANGEL-ASPECT study design

Author

Ren, Zeguang, Huo, Xiaochuan, Ma, Gaoting, Tong, Xu, Kumar, Jay, Pressman, Elliot, Chen, Wenhuo, Yuan, Guangxiong, Wang, Alvin Yi-Chou, Wei, Ming, Zhang, Jiangang, Nan, Guangxian, Zhu, Qiyi, Liu, Yajie, Zhang, Liyong, Song, Weigen, Zhou, Zhiming, Wang, Guoqing, Li, Tianxiao, Luo, Jun, Wang, En, Ling, Wentong, Ju, Dongsheng, Song, Cunfeng, Liu, Shu-Dong, Gui, Liqiang, Li, Tong, Liu, Yan, Zhao, Junfeng, Guo, Zaiyu, Zheng, Hongbo, Sun, Yaxuan, Xu, Na, Wang, Yong Jun, and Miao, Zhongrong

Published
2022
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22. Comparing the efficacy and safety of the Skyflow device with those of the Solitaire FR stent in patients with acute ischemic stroke: a prospective, multicenter, randomized, non-inferiority clinical trial

Author

Zhou, Tengfei, Li, Tianxiao, Zhu, Liangfu, Li, Zhaoshuo, Li, Qiang, Bai, Wei-xing, He, Ying-kun, Liu, Xiao, Guan, Haitao, Long, Youming, Liu, Jinchao, Wei, Liping, Nan, Guangxian, Li, Hongzhuang, Wen, Changming, Zhang, Yude, Qiao, Hongyu, Han, Jianfeng, Wang, Shouchun, Gu, Jianping, Cai, Xueli, Liu, Sheng, and Zhao, Zhenxin

Abstract

BackgroundMechanical thrombectomy is the standard treatment for acute ischemic stroke (AIS) with large vessel occlusion (LVO) in the anterior circulation. This trial aimed to indicate whether Skyflow, a new thrombectomy device, could achieve the same safety and efficacy as Solitaire FR in the treatment of AIS.MethodsThis study was a prospective, multicenter, randomized, single blind, parallel, positive controlled, non-inferiority clinical trial. Patients with intracranial anterior circulation LVO within 8 hours from onset were included to receive thrombectomy treatment with either the Skyflow or Solitaire FR stent retriever. The primary endpoint was the rate of successful reperfusion (modified Treatment In Cerebral Infarction (mTICI) ≥2b) after the operation. The safety endpoints were the rate of symptomatic intracranial hemorrhage (sICH) and subarachnoid hemorrhage (SAH) at 24 hours after operation.ResultsA total of 95 and 97 patients were involved in the Skyflow group and Solitaire FR group, respectively. A successful reperfusion (mTICI ≥2b) was finally achieved in 84 (88.4%) patients in the Skyflow group and 80 (82.5%) patients in the Solitaire FR group. Skyflow was non-inferior to Solitaire FR in regard to the primary outcome, with the criterion of a non-inferiority margin of 12.5% (p=0.0002) after being adjusted for the combined center effect and the National Institutes of Health Stroke Scale (NIHSS) score. The rate of periprocedural sICH and SAH did not differ significantly between the two groups.ConclusionEndovascular thrombectomy with the Skyflow stent retriever was non-inferior to Solitaire FR with regard to successful reperfusion in AIS due to LVO (with a pre-specified non-inferiority margin of 12.5%).

Published
2022
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23. Optical Coherence Tomography–Guided Stenting for Common Carotid Free-Floating Thrombus

Author

Shen, Guangxun, Zhao, Jingmin, Mao, Ying, Yu, Xiao, Lee, Kwee-Yum, and Nan, Guangxian

Abstract

A 57-year-old male with a history of esophagus cancer presented with acute dysarthria and mild weakness in his left extremities. Carotid duplex ultrasonography demonstrated a carotid free-floating thrombus (CFFT) in the right common carotid artery (CCA) extending to innominate artery (IA). It was difficult to determine the entity and the proximal end of the thrombus on digital subtraction angiography (DSA), but intravascular optical coherence tomography (OCT) showed unique morphological features and identified the exact location of the proximal and distal ends of the thrombus through the number of guide-wire artifacts, facilitating in making an informed decision regarding stent landing. After OCT-guided carotid artery stenting, DSA showed no residual free-floating thrombus and stenosis with complete recanalization in the CCA and IA. Our case highlights the rarity of a CFFT occurring in an uncommon location and OCT as a valuable adjunct to DSA in the management of CFFTs.Clinical Impact Digital subtraction angiography (DSA) has traditionally been considered an effective method for visualizing carotid free-floating thrombus (CFFT), but it falls short in providing detailed structures of the lumen and the composition of thrombi, making it challenging to determine the etiology. Intravascular optical coherence tomography (OCT) is a valuable adjunct to DSA that can precisely evaluate the characteristics of the intrinsic vessel wall and accurately distinguish between red and white thrombus, providing clues to the etiology of CFFTs. Moreover, OCT not only precisely determined the scope of a floating thrombus but also provided guidance for decision-making in endovascular treatment.

Published
2024
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24. Genetically predicted small dense low-density lipoprotein cholesterol and ischemic stroke subtype: multivariable Mendelian randomization study.

Author

Yu X, Shen G, Zhang Y, Cui C, Zha Y, Li P, Li L, Wang X, and Nan G

Subjects
Humans, Polymorphism, Single Nucleotide, Genetic Predisposition to Disease, Female, Risk Factors, Male, Mendelian Randomization Analysis, Ischemic Stroke genetics, Ischemic Stroke epidemiology, Ischemic Stroke blood, Cholesterol, LDL blood, Genome-Wide Association Study
Abstract

Purpose: Small dense low-density lipoprotein cholesterol (S-LDL-C) has been suggested as a particularly atherogenic factor for ischemic stroke (IS) in observational studies, but the causality regarding the etiological subtype remains unclear. This study aims to explore the causal effects of small dense low-density lipoprotein cholesterol (S-LDL-C), medium (M-LDL-C) and large (L-LDL-C) subfractions on the lifetime risk of ischemic stroke (IS) and main subtypes using two-sample Mendelian randomization (TSMR) design., Methods: We identified genetic instruments for S-LDL-C, M-LDL-C and L-LDL-C from a genome-wide association study of 115 082 UK Biobank participants. Summary-level data for genetic association of any ischemic stroke (AIS), large artery stroke (LAS), small vessel stroke (SVS) and cardioembolic stroke (CES) were obtained from MEGASTROKE consortium. Accounting for the pleiotropic effects of triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C), we conducted multivariable TSMR analysis., Results: In univariable TSMR, we found a causal association between genetically predicted S-LDL-C and LAS (IVW-FE: odds ratio (OR) = 1.481, 95% confidence interval (CI): 1.117-1.963, P = 0.006, q = 0.076) but not AIS, SVS or CES. No causal effects were observed for M-LDL-C or L-LDL-C in terms of AIS and IS subtype. In multivariable analysis, the causal association between S-LDL-C and LAS remained significant (IVE-MRE: OR = 1.329, 95% CI: 1.106-1.597, P = 0.002)., Conclusions: Findings supported a causal association between S-LDL-C and LAS. Further studies are warranted to elucidate the underlying mechanism and clinical benefit of targeting S-LDL-C., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer Y-XC declared a shared affiliation with the author PL to the handling editor at the time of the review., (Copyright © 2024 Yu, Shen, Zhang, Cui, Zha, Li, Li, Wang and Nan.)

Published
2024
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25. Endovascular treatment for severe cerebral venous sinus thrombosis in a patient with polycythemia vera and nephrotic syndrome: a case report.

Author

Sun J, Nan G, Zhang L, Gao Y, and Cui M

Abstract

Cerebral venous sinus thrombosis (CVST) is a rare cerebrovascular disease that can occur at any age and generally has a good prognosis. Polycythemia vera and nephrotic syndrome are uncommon risk factors for cerebral venous sinus thrombosis. A dilemma exists in the treatment of cerebral venous sinus thrombosis with polycythemia vera and nephrotic syndrome, as some cases are refractory to first-line therapy. Here, we report a patient with CVST who presented with a generalized seizure and was found to have bilateral frontal lobe hemorrhage and subarachnoid hemorrhage. Brain magnetic resonance venography showed extensive cerebral venous sinus thrombosis extending from the superior sagittal sinus to the left internal jugular vein. Further testing revealed that the patient had polycythemia vera and nephrotic syndrome. Anticoagulation therapy had limited effects. He underwent endovascular intervention, including stent thrombectomy, intermediate catheter aspiration, balloon dilatation, and local intravenous thrombolysis, to achieve revascularization. After 9 months of follow-up, the patient had recovered well without any sequelae. This case shows that in patients with critical cerebral venous sinus thrombosis who fail to respond to anticoagulant therapy, stent thrombectomy combined with intermediate catheter aspiration, balloon dilation, and local thrombolysis may be a viable option. This strategy can quickly resolve venous sinus obstruction and improve the prognosis of patients with critical cerebral venous sinus thrombosis., Competing Interests: None., (AJTR Copyright © 2023.)

Published
2023

26. Cerebral stroke mimics associated with spinal vascular disease: two case reports.

Author

Li H and Nan G

Abstract

Several diseases produce symptoms similar to those of a cerebral stroke, resulting in their misdiagnosis as stroke. Cerebral stroke mimics are common in emergency rooms. We report two cases of cerebral stroke mimics to attract the attention of clinicians, especially emergency room doctors. In one case, a patient with spontaneous spinal epidural hematoma (SSEH) exhibited lower-right limb numbness and weakness. In the other, a patient with spinal cord infarction (SCI) had numbness and weakness of the lower-left limb. Both cases were misdiagnosed as cerebral strokes in the emergency room. One of the patients underwent hematoma removal surgery, and the other received medical treatment for spinal cord infarction. Patients' symptoms improved, but the sequelae remained. Single-limb numbness and weakness are an uncommon initial presentation of spinal vascular disease that can lead to its misdiagnosis. When encountering single-limb numbness and weakness, it is necessary to consider the differential diagnosis of spinal vascular disease, thereby reducing misdiagnosis., Competing Interests: None., (AJTR Copyright © 2023.)

Published
2023

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