26 results on '"Nakielski P."'
Search Results
2. iPSC-neural crest derived cells embedded in 3D printable bio-ink promote cranial bone defect repair
- Author
-
Glaeser, Juliane D., Bao, Xianchao, Kaneda, Giselle, Avalos, Pablo, Behrens, Phillip, Salehi, Khosrowdad, Da, Xiaoyu, Chen, Angel, Castaneda, Chloe, Nakielski, Pawel, Jiang, Wensen, Tawackoli, Wafa, and Sheyn, Dmitriy
- Published
- 2022
- Full Text
- View/download PDF
3. Chameleon-inspired multifunctional plasmonic nanoplatforms for biosensing applications
- Author
-
Ziai, Yasamin, Petronella, Francesca, Rinoldi, Chiara, Nakielski, Paweł, Zakrzewska, Anna, Kowalewski, Tomasz A., Augustyniak, Weronika, Li, Xiaoran, Calogero, Antonella, Sabała, Izabela, Ding, Bin, De Sio, Luciano, and Pierini, Filippo
- Published
- 2022
- Full Text
- View/download PDF
4. Adhesive Antibacterial Moisturizing Nanostructured Skin Patch for Sustainable Development of Atopic Dermatitis Treatment in Humans.
- Author
-
Kosik-Kozioł, Alicja, Nakielski, Paweł, Rybak, Daniel, Frączek, Wiktoria, Rinoldi, Chiara, Lanzi, Massimiliano, Grodzik, Marta, and Pierini, Filippo
- Published
- 2024
- Full Text
- View/download PDF
5. An Innovative Floating System with a Savonius Rotor as a Horizontal-Axis Wind Turbine
- Author
-
Grzelak, Joanna, Carrillo, Lara Guijarro, Nakielski, Jacek, Piotrowicz, Michał, and Doerffer, Krzysztof
- Abstract
In this project, an innovative wind turbine was designed for a floating plant. A large Savonius rotor was replaced with a double-rotor wind turbine implemented as a horizontal-axis turbine. This double rotor was positioned on the tip of a thrust plate and fixed to the deck of a catamaran. Simple 2D numerical simulations were performed to confirm the effectiveness of the concept. An analysis of the floating system configuration was carried out, and the loads and stresses on the system components were verified. Next, floating supports with appropriate sizes were selected to counteract the forces on the wind turbine system. Finally, an anchoring system with full rotational freedom was selected for the floating platform. The present work was conducted as part of a Master’s thesis.
- Published
- 2024
- Full Text
- View/download PDF
6. Engineering surgical face masks with photothermal and photodynamic plasmonic nanostructures for enhancing filtration and on-demand pathogen eradicationElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3bm01125a
- Author
-
Haghighat Bayan, Mohammad Ali, Rinoldi, Chiara, Rybak, Daniel, Zargarian, Seyed Shahrooz, Zakrzewska, Anna, Cegielska, Olga, Põhako-Palu, Kaisa, Zhang, Shichao, Stobnicka-Kupiec, Agata, Górny, Rafa L., Nakielski, Pawe, Kogermann, Karin, De Sio, Luciano, Ding, Bin, and Pierini, Filippo
- Abstract
The shortage of face masks and the lack of antipathogenic functions has been significant since the recent pandemic's inception. Moreover, the disposal of an enormous number of contaminated face masks not only carries a significant environmental impact but also escalates the risk of cross-contamination. This study proposes a strategy to upgrade available surgical masks into antibacterial masks with enhanced particle and bacterial filtration. Plasmonic nanoparticles can provide photodynamic and photothermal functionalities for surgical masks. For this purpose, gold nanorods act as on-demand agents to eliminate pathogens on the surface of the masks upon near-infrared light irradiation. Additionally, the modified masks are furnished with polymer electrospun nanofibrous layers. These electrospun layers can enhance the particle and bacterial filtration efficiency, not at the cost of the pressure drop of the mask. Consequently, fabricating these prototype masks could be a practical approach to upgrading the available masks to alleviate the environmental toll of disposable face masks.
- Published
- 2024
- Full Text
- View/download PDF
7. Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers
- Author
-
Nakielski, Paweł, Rybak, Daniel, Jezierska-Woźniak, Katarzyna, Rinoldi, Chiara, Sinderewicz, Emilia, Staszkiewicz-Chodor, Joanna, Haghighat Bayan, Mohammad Ali, Czelejewska, Wioleta, Urbanek, Olga, Kosik-Kozioł, Alicja, Barczewska, Monika, Skomorowski, Mateusz, Holak, Piotr, Lipiński, Seweryn, Maksymowicz, Wojciech, and Pierini, Filippo
- Abstract
Current treatments of degenerated intervertebral discs often provide only temporary relief or address specific causes, necessitating the exploration of alternative therapies. Cell-based regenerative approaches showed promise in many clinical trials, but limitations such as cell death during injection and a harsh disk environment hinder their effectiveness. Injectable microscaffolds offer a solution by providing a supportive microenvironment for cell delivery and enhancing bioactivity. This study evaluated the safety and feasibility of electrospun nanofibrous microscaffolds modified with chitosan (CH) and chondroitin sulfate (CS) for treating degenerated NP tissue in a large animal model. The microscaffolds facilitated cell attachment and acted as an effective delivery system, preventing cell leakage under a high disc pressure. Combining microscaffolds with bone marrow-derived mesenchymal stromal cells demonstrated no cytotoxic effects and proliferation over the entire microscaffolds. The administration of cells attached to microscaffolds into the NP positively influenced the regeneration process of the intervertebral disc. Injectable poly(l-lactide-co-glycolide) and poly(l-lactide) microscaffolds enriched with CH or CS, having a fibrous structure, showed the potential to promote intervertebral disc regeneration. These features collectively address critical challenges in the fields of tissue engineering and regenerative medicine, particularly in the context of intervertebral disc degeneration.
- Published
- 2023
- Full Text
- View/download PDF
8. Analysis of the Environmental Impact of the Hull Construction of a Small Vessel Based on LCA
- Author
-
Nakielski, Jacek
- Abstract
In recent years, issues related to the impact of human activity on the natural environment have become pressing, and the challenge of global warming necessitates immediate action. To support environmental protection efforts, it has become imperative to adopt a broader perspective when evaluating various products and systems. A valuable tool for such assessments is a life cycle assessment (LCA), which enables a comprehensive analysis of the entire life cycle of a product.
- Published
- 2023
- Full Text
- View/download PDF
9. Synthesis and Properties of 5‑Azaullazines.
- Author
-
Janke, Sophie, Boldt, Sebastian, Nakielski, Pascal, Villinger, Alexander, Ehlers, Peter, and Langer, Peter
- Published
- 2023
- Full Text
- View/download PDF
10. In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface.
- Author
-
Rinoldi, Chiara, Ziai, Yasamin, Zargarian, Seyed Shahrooz, Nakielski, Paweł, Zembrzycki, Krzysztof, Haghighat Bayan, Mohammad Ali, Zakrzewska, Anna Beata, Fiorelli, Roberto, Lanzi, Massimiliano, Kostrzewska-Księżyk, Agnieszka, Czajkowski, Rafał, Kublik, Ewa, Kaczmarek, Leszek, and Pierini, Filippo
- Published
- 2023
- Full Text
- View/download PDF
11. Near‐infrared light activated core‐shell electrospun nanofibers decorated with photoactive plasmonic nanoparticles for on‐demand smart drug delivery applications
- Author
-
Haghighat Bayan, Mohammad Ali, Dias, Yasmin Juliane, Rinoldi, Chiara, Nakielski, Paweł, Rybak, Daniel, Truong, Yen B., Yarin, Alexander L., and Pierini, Filippo
- Abstract
Over the last few years, traditional drug delivery systems (DDSs) have been transformed into smart DDSs. Recent advancements in biomedical nanotechnology resulted in introducing stimuli‐responsiveness to drug vehicles. Nanoplatforms can enhance drug release efficacy while reducing the side effects of drugs by taking advantage of the responses to specific internal or external stimuli. In this study, we developed an electrospun nanofibrous photo‐responsive DDSs. The photo‐responsivity of the platform enables on‐demand elevated drug release. Furthermore, it can provide a sustained release profile and prevent burst release and high concentrations of drugs. A coaxial electrospinning setup paired with an electrospraying technique is used to fabricate core‐shell PVA‐PLGA nanofibers decorated with plasmonic nanoparticles. The fabricated nanofibers have a hydrophilic PVA and Rhodamine‐B (RhB) core, while the shell is hydrophobic PLGA decorated with gold nanorods (Au NRs). The presence of plasmonic nanoparticles enables the platform to twice the amount of drug release besides exhibiting a long‐term release. Investigations into the photo‐responsive release mechanism demonstrate the system's potential as a “smart” drug delivery platform.
- Published
- 2023
- Full Text
- View/download PDF
12. Nanotechnology Transition Roadmap toward Multifunctional Stimuli-Responsive Face Masks.
- Author
-
Zakrzewska, Anna, Haghighat Bayan, Mohammad Ali, Nakielski, Paweł, Petronella, Francesca, De Sio, Luciano, and Pierini, Filippo
- Published
- 2022
- Full Text
- View/download PDF
13. In VivoChronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface
- Author
-
Rinoldi, Chiara, Ziai, Yasamin, Zargarian, Seyed Shahrooz, Nakielski, Paweł, Zembrzycki, Krzysztof, Haghighat Bayan, Mohammad Ali, Zakrzewska, Anna Beata, Fiorelli, Roberto, Lanzi, Massimiliano, Kostrzewska-Księżyk, Agnieszka, Czajkowski, Rafał, Kublik, Ewa, Kaczmarek, Leszek, and Pierini, Filippo
- Abstract
In neuroscience, the acquisition of neural signals from the brain cortex is crucial to analyze brain processes, detect neurological disorders, and offer therapeutic brain–computer interfaces. The design of neural interfaces conformable to the brain tissue is one of today’s major challenges since the insufficient biocompatibility of those systems provokes a fibrotic encapsulation response, leading to an inaccurate signal recording and tissue damage precluding long-term/permanent implants. The design and production of a novel soft neural biointerface made of polyacrylamide hydrogels loaded with plasmonic silver nanocubes are reported herein. Hydrogels are surrounded by a silicon-based template as a supporting element for guaranteeing an intimate neural-hydrogel contact while making possible stable recordings from specific sites in the brain cortex. The nanostructured hydrogels show superior electroconductivity while mimicking the mechanical characteristics of the brain tissue. Furthermore, in vitrobiological tests performed by culturing neural progenitor cells demonstrate the biocompatibility of hydrogels along with neuronal differentiation. In vivochronic neuroinflammation tests on a mouse model show no adverse immune response toward the nanostructured hydrogel-based neural interface. Additionally, electrocorticography acquisitions indicate that the proposed platform permits long-term efficient recordings of neural signals, revealing the suitability of the system as a chronic neural biointerface.
- Published
- 2023
- Full Text
- View/download PDF
14. Highly Adhesive, Stretchable and Breathable Gelatin Methacryloyl-based Nanofibrous Hydrogels for Wound Dressings.
- Author
-
Yumin Liu, Qiusheng Wang, Xueting Liu, Pawel Nakielski, Filippo Pierini, Xiaoran Li, Jianyong Yu, and Bin Ding
- Published
- 2022
- Full Text
- View/download PDF
15. Smart plasmonic hydrogels based on gold and silver nanoparticles for biosensing application
- Author
-
Ziai, Yasamin, Rinoldi, Chiara, Nakielski, Paweł, De Sio, Luciano, and Pierini, Filippo
- Abstract
The importance of having a fast, accurate, and reusable track for detection has led to an increase investigation in the field of biosensing. Optical biosensing using plasmonic nanoparticles, such as gold and silver, introduces localized surface plasmon resonance (LSPR) sensors. LSPR biosensors are progressive in their sensing precision and detection limit. Also, the possibility to tune the sensing range by varying the size and shape of the particles has made them extremely useful. Hydrogels being hydrophilic 3D networks can be beneficial when used as matrices, because of a more efficient biorecognition. Stimuli-responsive hydrogels can be great candidates, as their response to a stimulus can increase recognition and detection. This article highlights recent advances in combining hydrogels as a matrix and plasmonic nanoparticles as sensing elements. The end capability and diversity of these novel biosensors in different applications in the near future are discussed.
- Published
- 2022
- Full Text
- View/download PDF
16. NIR-Light Activable 3D Printed Platform Nanoarchitectured with Electrospun Plasmonic Filaments for On Demand Treatment of Infected Wounds.
- Author
-
Rybak D, Du J, Nakielski P, Rinoldi C, Kosik-Kozioł A, Zakrzewska A, Wu H, Li J, Li X, Yu Y, Ding B, and Pierini F
- Abstract
Bacterial infections can lead to severe complications that adversely affect wound healing. Thus, the development of effective wound dressings has become a major focus in the biomedical field, as current solutions remain insufficient for treating complex, particularly chronic wounds. Designing an optimal environment for healing and tissue regeneration is essential. This study aims to optimize a multi-functional 3D printed hydrogel for infected wounds. A dexamethasone (DMX)-loaded electrospun mat, incorporated with gold nanorods (AuNRs), is structured into short filaments (SFs). The SFs are 3D printed into gelatine methacrylate (GelMA) and sodium alginate (SA) scaffold. The photo-responsive AuNRs within SFs significantly enhanced DXM release when exposed to near-infrared (NIR) light. The material exhibits excellent photothermal properties, biocompatibility, and antibacterial activity under NIR irradiation, effectively eliminating Staphylococcus aureus and Escherichia coli in vitro. In vivo, material combined with NIR light treatment facilitate infectes wound healing, killing S. aureus bacteria, reduced inflammation, and induced vascularization. The final materials' shape can be adjusted to the skin defect, release the anti-inflammatory DXM on-demand, provide antimicrobial protection, and accelerate the healing of chronic wounds., (© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
17. The Future of Bone Repair: Emerging Technologies and Biomaterials in Bone Regeneration.
- Author
-
Łuczak JW, Palusińska M, Matak D, Pietrzak D, Nakielski P, Lewicki S, Grodzik M, and Szymański Ł
- Subjects
- Humans, Animals, Printing, Three-Dimensional, Bone and Bones, Bone Regeneration, Biocompatible Materials chemistry, Tissue Engineering methods, Tissue Scaffolds chemistry, Bone Substitutes therapeutic use, Bone Substitutes chemistry
- Abstract
Bone defects and fractures present significant clinical challenges, particularly in orthopedic and maxillofacial applications. While minor bone defects may be capable of healing naturally, those of a critical size necessitate intervention through the use of implants or grafts. The utilization of traditional methodologies, encompassing autografts and allografts, is constrained by several factors. These include the potential for donor site morbidity, the restricted availability of suitable donors, and the possibility of immune rejection. This has prompted extensive research in the field of bone tissue engineering to develop advanced synthetic and bio-derived materials that can support bone regeneration. The optimal bone substitute must achieve a balance between biocompatibility, bioresorbability, osteoconductivity, and osteoinductivity while simultaneously providing mechanical support during the healing process. Recent innovations include the utilization of three-dimensional printing, nanotechnology, and bioactive coatings to create scaffolds that mimic the structure of natural bone and enhance cell proliferation and differentiation. Notwithstanding the advancements above, challenges remain in optimizing the controlled release of growth factors and adapting materials to various clinical contexts. This review provides a comprehensive overview of the current advancements in bone substitute materials, focusing on their biological mechanisms, design considerations, and clinical applications. It explores the role of emerging technologies, such as additive manufacturing and stem cell-based therapies, in advancing the field. Future research highlights the need for multidisciplinary collaboration and rigorous testing to develop advanced bone graft substitutes, improving outcomes and quality of life for patients with complex defects.
- Published
- 2024
- Full Text
- View/download PDF
18. Iodinated PSMA Ligands as XFI Tracers for Targeted Cell Imaging and Characterization of Nanoparticles.
- Author
-
Kerpa S, Holzapfel M, Staufer T, Kuhrwahl R, Mutas M, Werner S, Schulze VR, Nakielski P, Feliu N, Oetjen E, Haak J, Ziegler F, Buchin R, Han J, Parak WJ, Grüner F, and Maison W
- Subjects
- Humans, Ligands, Cell Line, Tumor, Male, Prostatic Neoplasms metabolism, Prostatic Neoplasms diagnostic imaging, Nanoparticles chemistry, Optical Imaging methods, Glutamate Carboxypeptidase II metabolism, Antigens, Surface metabolism, Quantum Dots chemistry
- Abstract
Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Despite this, current diagnostic tools are still not satisfactory, lacking sensitivity for early-stage or single-cell diagnosis. This study describes the development of small-molecule tracers for the well-known tumor marker prostate-specific membrane antigen (PSMA). These tracers contain a urea motif for PSMA-targeting and iodinated aromatic moieties to allow detection via X-ray fluorescence imaging (XFI). Tracers with a triiodobenzoyl moiety allowed the specific targeting and successful imaging of PSMA+ cell lines with XFI. The XFI-measured uptake of 7.88 × 10
-18 mol iodine (I) per cell is consistent with the uptake of known PSMA tracers measured by other techniques such as inductively coupled plasma mass spectrometry (ICP-MS). This is the first successful application of XFI to tumor cell targeting with a small-molecule tracer. In addition, iodinated tracers were used for the characterization of quantum dots (QDs) conjugated to PSMA-targeting urea motifs. The resulting targeted QD conjugates were shown to selectively bind PSMA+ cell lines via confocal microscopy. The immobilized iodinated targeting vectors allowed the determination of the tracer/QD ratio via XFI and ICP-MS. This ratio is a key property of targeted particles and difficult to measure by other techniques.- Published
- 2024
- Full Text
- View/download PDF
19. Injectable PLGA Microscaffolds with Laser-Induced Enhanced Microporosity for Nucleus Pulposus Cell Delivery.
- Author
-
Nakielski P, Kosik-Kozioł A, Rinoldi C, Rybak D, More N, Wechsler J, Lehmann TP, Głowacki M, Stępak B, Rzepna M, Marinelli M, Lanzi M, Seliktar D, Mohyeddinipour S, Sheyn D, and Pierini F
- Abstract
Intervertebral disc (IVD) degeneration is a leading cause of lower back pain (LBP). Current treatments primarily address symptoms without halting the degenerative process. Cell transplantation offers a promising approach for early-stage IVD degeneration, but challenges such as cell viability, retention, and harsh host environments limit its efficacy. This study aimed to compare the injectability and biocompatibility of human nucleus pulposus cells (hNPC) attached to two types of microscaffolds designed for minimally invasive delivery to IVD. Microscaffolds are developed from poly(lactic-co-glycolic acid) (PLGA) using electrospinning and femtosecond laser structuration. These microscaffolds are tested for their physical properties, injectability, and biocompatibility. This study evaluates cell adhesion, proliferation, and survival in vitro and ex vivo within a hydrogel-based nucleus pulposus model. The microscaffolds demonstrate enhanced surface architecture, facilitating cell adhesion and proliferation. Laser structuration improved porosity, supporting cell attachment and extracellular matrix deposition. Injectability tests show that microscaffolds can be delivered through small-gauge needles with minimal force, maintaining high cell viability. The findings suggest that laser-structured PLGA microscaffolds are viable for minimally invasive cell delivery. These microscaffolds enhance cell viability and retention, offering potential improvements in the therapeutic efficiency of cell-based treatments for discogenic LBP., (© 2024 Wiley‐VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
20. Injectable and self-healable nano-architectured hydrogel for NIR-light responsive chemo- and photothermal bacterial eradication.
- Author
-
Rybak D, Rinoldi C, Nakielski P, Du J, Haghighat Bayan MA, Zargarian SS, Pruchniewski M, Li X, Strojny-Cieślak B, Ding B, and Pierini F
- Subjects
- Staphylococcus aureus, Escherichia coli, Gram-Negative Bacteria, Gram-Positive Bacteria, Anti-Bacterial Agents pharmacology, Hydrogels pharmacology
- Abstract
Hydrogels with multifunctional properties activated at specific times have gained significant attention in the biomedical field. As bacterial infections can cause severe complications that negatively impact wound repair, herein, we present the development of a stimuli-responsive, injectable, and in situ -forming hydrogel with antibacterial, self-healing, and drug-delivery properties. In this study, we prepared a Pluronic F-127 (PF127) and sodium alginate (SA)-based hydrogel that can be targeted to a specific tissue via injection. The PF127/SA hydrogel was incorporated with polymeric short-filaments (SFs) containing an anti-inflammatory drug - ketoprofen, and stimuli-responsive polydopamine (PDA) particles. The hydrogel, after injection, could be in situ gelated at the body temperature, showing great in vitro stability and self-healing ability after 4 h of incubation. The SFs and PDA improved the hydrogel injectability and compressive strength. The introduction of PDA significantly accelerated the KET release under near-infrared light exposure and extended its release validity period. The excellent composites' photo-thermal performance led to antibacterial activity against representative Gram-positive and Gram-negative bacteria, resulting in 99.9% E. coli and S. aureus eradication after 10 min of NIR light irradiation. In vitro , fibroblast L929 cell studies confirmed the materials' biocompatibility and paved the way toward further in vivo and clinical application of the system for chronic wound treatments.
- Published
- 2024
- Full Text
- View/download PDF
21. Developing strategies to optimize the anchorage between electrospun nanofibers and hydrogels for multi-layered plasmonic biomaterials.
- Author
-
Ziai Y, Lanzi M, Rinoldi C, Zargarian SS, Zakrzewska A, Kosik-Kozioł A, Nakielski P, and Pierini F
- Abstract
Polycaprolactone (PCL), a recognized biopolymer, has emerged as a prominent choice for diverse biomedical endeavors due to its good mechanical properties, exceptional biocompatibility, and tunable properties. These attributes render PCL a suitable alternative biomaterial to use in biofabrication, especially the electrospinning technique, facilitating the production of nanofibers with varied dimensions and functionalities. However, the inherent hydrophobicity of PCL nanofibers can pose limitations. Conversely, acrylamide-based hydrogels, characterized by their interconnected porosity, significant water retention, and responsive behavior, present an ideal matrix for numerous biomedical applications. By merging these two materials, one can harness their collective strengths while potentially mitigating individual limitations. A robust interface and effective anchorage during the composite fabrication are pivotal for the optimal performance of the nanoplatforms. Nanoplatforms are subject to varying degrees of tension and physical alterations depending on their specific applications. This is particularly pertinent in the case of layered nanostructures, which require careful consideration to maintain structural stability and functional integrity in their intended applications. In this study, we delve into the influence of the fiber dimensions, orientation and surface modifications of the nanofibrous layer and the hydrogel layer's crosslinking density on their intralayer interface to determine the optimal approach. Comprehensive mechanical pull-out tests offer insights into the interfacial adhesion and anchorage between the layers. Notably, plasma treatment of the hydrophobic nanofibers and the stiffness of the hydrogel layer significantly enhance the mechanical effort required for fiber extraction from the hydrogels, indicating improved anchorage. Furthermore, biocompatibility assessments confirm the potential biomedical applications of the proposed nanoplatforms., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)
- Published
- 2024
- Full Text
- View/download PDF
22. Nanostructured graphene oxide enriched with metallic nanoparticles as a biointerface to enhance cell adhesion through mechanosensory modifications.
- Author
-
Pruchniewski M, Sawosz E, Sosnowska-Ławnicka M, Ostrowska A, Łojkowski M, Koczoń P, Nakielski P, Kutwin M, Jaworski S, and Strojny-Cieślak B
- Subjects
- Humans, Cell Adhesion, Gold pharmacology, Gold chemistry, Biocompatible Materials pharmacology, Nanostructures chemistry, Metal Nanoparticles chemistry, Graphite pharmacology, Graphite chemistry
- Abstract
Nanostructuring is a process involving surface manipulation at the nanometric level, which improves the mechanical and biological properties of biomaterials. Specifically, it affects the mechanotransductive perception of the microenvironment of cells. Mechanical force conversion into an electrical or chemical signal contributes to the induction of a specific cellular response. The relationship between the cells and growth surface induces a biointerface-modifying cytophysiology and consequently a therapeutic effect. In this study, we present the fabrication of graphene oxide (GO)-based nanofilms decorated with metallic nanoparticles (NPs) as potential coatings for biomaterials. Our investigation showed the effect of decorating GO with metallic NPs for the modification of the physicochemical properties of nanostructures in the form of nanoflakes and nanofilms. A comprehensive biocompatibility screening panel revealed no disturbance in the metabolic activity of human fibroblasts (HFFF2) and bone marrow stroma cells (HS-5) cultivated on the GO nanofilms decorated with gold and copper NPs, whereas a significant cytotoxic effect of the GO nanocomplex decorated with silver NPs was demonstrated. The GO nanofilm decorated with gold NPs beneficially managed early cell adhesion as a result of the transient upregulation of α1β5 integrin expression, acceleration of cellspreading, and formation of elongated filopodia. Additionally, the cells, sensing the substrate derived from the nanocomplex enriched with gold NPs, showed reduced elasticity and altered levels of vimentin expression. In the future, GO nanocomplexes decorated with gold NPs can be incorporated in the structure of architecturally designed biomimetic biomaterials as biocompatible nanostructuring agents with proadhesive properties.
- Published
- 2023
- Full Text
- View/download PDF
23. Conducting polymer-based nanostructured materials for brain-machine interfaces.
- Author
-
Ziai Y, Zargarian SS, Rinoldi C, Nakielski P, Sola A, Lanzi M, Truong YB, and Pierini F
- Subjects
- Polymers chemistry, Artificial Intelligence, Hydrogels chemistry, Brain-Computer Interfaces, Nanostructures
- Abstract
As scientists discovered that raw neurological signals could translate into bioelectric information, brain-machine interfaces (BMI) for experimental and clinical studies have experienced massive growth. Developing suitable materials for bioelectronic devices to be used for real-time recording and data digitalizing has three important necessitates which should be covered. Biocompatibility, electrical conductivity, and having mechanical properties similar to soft brain tissue to decrease mechanical mismatch should be adopted for all materials. In this review, inorganic nanoparticles and intrinsically conducting polymers are discussed to impart electrical conductivity to systems, where soft materials such as hydrogels can offer reliable mechanical properties and a biocompatible substrate. Interpenetrating hydrogel networks offer more mechanical stability and provide a path for incorporating polymers with desired properties into one strong network. Promising fabrication methods, like electrospinning and additive manufacturing, allow scientists to customize designs for each application and reach the maximum potential for the system. In the near future, it is desired to fabricate biohybrid conducting polymer-based interfaces loaded with cells, giving the opportunity for simultaneous stimulation and regeneration. Developing multi-modal BMIs, Using artificial intelligence and machine learning to design advanced materials are among the future goals for this field. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease., (© 2023 Wiley Periodicals LLC.)
- Published
- 2023
- Full Text
- View/download PDF
24. Evolution of nanostructured skin patches towards multifunctional wearable platforms for biomedical applications.
- Author
-
Rybak D, Su YC, Li Y, Ding B, Lv X, Li Z, Yeh YC, Nakielski P, Rinoldi C, Pierini F, and Dodda JM
- Subjects
- Electronics, Electric Power Supplies, Prostheses and Implants, Wearable Electronic Devices
- Abstract
Recent advances in the field of skin patches have promoted the development of wearable and implantable bioelectronics for long-term, continuous healthcare management and targeted therapy. However, the design of electronic skin (e-skin) patches with stretchable components is still challenging and requires an in-depth understanding of the skin-attachable substrate layer, functional biomaterials and advanced self-powered electronics. In this comprehensive review, we present the evolution of skin patches from functional nanostructured materials to multi-functional and stimuli-responsive patches towards flexible substrates and emerging biomaterials for e-skin patches, including the material selection, structure design and promising applications. Stretchable sensors and self-powered e-skin patches are also discussed, ranging from electrical stimulation for clinical procedures to continuous health monitoring and integrated systems for comprehensive healthcare management. Moreover, an integrated energy harvester with bioelectronics enables the fabrication of self-powered electronic skin patches, which can effectively solve the energy supply and overcome the drawbacks induced by bulky battery-driven devices. However, to realize the full potential offered by these advancements, several challenges must be addressed for next-generation e-skin patches. Finally, future opportunities and positive outlooks are presented on the future directions of bioelectronics. It is believed that innovative material design, structure engineering, and in-depth study of fundamental principles can foster the rapid evolution of electronic skin patches, and eventually enable self-powered close-looped bioelectronic systems to benefit mankind.
- Published
- 2023
- Full Text
- View/download PDF
25. Corrigendum to "Electrospun nanofiber-reinforced three-dimensional chitosan matrices: Architectural, mechanical and biological properties" [J. Colloid interface Sci. 565 (2020) 416-425].
- Author
-
Wang L, Lv H, Liu L, Zhang Q, Nakielski P, Si Y, Cao J, Li X, Pierini F, Yu J, and Ding B
- Published
- 2022
- Full Text
- View/download PDF
26. Highly Adhesive, Stretchable and Breathable Gelatin Methacryloyl-based Nanofibrous Hydrogels for Wound Dressings.
- Author
-
Liu Y, Wang Q, Liu X, Nakielski P, Pierini F, Li X, Yu J, and Ding B
- Subjects
- Adhesives, Bandages, Hydrogels, Methacrylates, Gelatin pharmacology, Nanofibers therapeutic use
- Abstract
Adhesive and stretchable nanofibrous hydrogels have attracted extensive attraction in wound dressings, especially for joint wound treatment. However, adhesive hydrogels tend to display poor stretchable behavior. It is still a significant challenge to integrate excellent adhesiveness and stretchability in a nanofibrous hydrogel. Herein, a highly adhesive, stretchable, and breathable nanofibrous hydrogel was developed via an in situ hybrid cross-linking strategy of electrospun nanofibers comprising dopamine (DA) and gelatin methacryloyl (GelMA). Benefiting from the balance of cohesion and adhesion based on photocross-linking of methacryloyl (MA) groups in GelMA and the chemical/physical reaction between GelMA and DA, the nanofibrous hydrogels exhibited tunable adhesive and mechanical properties through varying MA substitution degrees of GelMA. The optimized GelMA60-DA exhibited 2.0 times larger tensile strength (2.4 MPa) with an elongation of about 200%, 2.3 times greater adhesive strength (9.1 kPa) on porcine skin, and 3.1 times higher water vapor transmission rate (10.9 kg m
-2 d-1 ) compared with gelatin nanofibrous hydrogels. In parallel, the GelMA60-DA nanofibrous hydrogels could facilitate cell growth and accelerate wound healing. This work presented a type of breathable nanofibrous hydrogels with excellent adhesive and stretchable capacities, showing great promise as wound dressings.- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.