1. Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones
- Author
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Z. A. Khushbaktova, M G Klinnikova, N.V. Tursunova, Yu. V. Tornuev, and Vladimir Nikolaevich Syrov
- Subjects
Hepatitis ,Toxic hepatitis ,Cytochrome ,biology ,General Medicine ,Metabolism ,Monooxygenase ,Nitrite reductase ,Sesquiterpene ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Biochemistry ,chemistry ,biology.protein ,medicine ,medicine.symptom ,Xenobiotic - Abstract
We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes of rats with toxic CCl4-induced hepatitis after a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg). It was found that toxic hepatitis was associated with significant inhibition of NADPH-cytochrome c-reductase, benzo(a)pyrene hydroxylase, and NADPH-diaphorase, reduced cytochrome P-450 content, and enhanced induction of nitrate/nitrite reductase with accumulation of NO metabolites in the liver. Administration of sesquiterpene lactones stimulated activity of the studied components of the cytochrome P-450 system and promoted recovery of the NOergic system components; the effects were most pronounced in 7 and 14 days after treatment.
- Published
- 2021
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