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A rigged hyperstrip distribution is a special class of hyperstrips. The study of hyperstrips and their generalizations in spaces with various fun­damental groups is of great interest due to numerous applications in mathematics and physics. A special place is occupied by regular hyper­strips, for which the characteristic planes of families of principal tangent hyperplanes do not contain directions tangent to the base surface of the hyperstrip. In this work, we use E. Cartan’s method of external differen­tial forms and the group-theoretic method of G. F. Laptev. In affine space, a hyperstrip distribution is considered, which at each point of the base surface is equipped with a tangent plane and a conjugate tangent line. The specification of the studied hyperstrip distribution in an affine space with respect to a 1st order reference and an existence theorem are given. The fields of affine normals of the 1st kind for Blaschke and Transon are constructed and the conditions for their coincidence are found. The definition of normal affine connection and normal centroaffine connection on the studied framed hyperstrip distribution is given.

In this paper, we study a special class of hyperbands, i. e., a framed hyperband distribution. The study of hyperbands and their generalizations in spaces with different fundamental groups is of great interest in connec­tion with numerous applications in mathematics and physics. A special place is occupied by regular hyperstrips, for which the characteristic planes of families of principal tangent hyperplanes do not contain direc­tions tangent to the basal surface of the hyperstrip. In this paper, we use the method of external differential forms of E. Cartan and the group-theoretic method of G. F. Laptev. We consider a regular hyperband distribution of an affine space equipped with a field of conjugate planes with respect to an asymptotic bundle of tensors of the basic surface. The definition of the studied hy­perband distribution in the affine space with respect to the 1st order frame is given and the existence theorem is proved. A sequence of fundamental geometric objects of the 1st and 2nd order of a hyperband distribution equip­ped with a field of conjugate planes is constructed. Fields of qua­sitensors are constructed that define the fields of normals of the first kind of the distribution of the characteristics of the hyperband distribution. In a differential neighborhood of the 2nd order, the fields of Transon normals of the 1st and 2nd kind are constructed. The conditions for the coincidence of the Transon normal and the Blaschke normal are found.

Aim. To study the structural and functional features of the carotid and femoral arteries using ultrasound duplex scanning of them in patients with hypertension undergoing periodic preventive medical examination.Material and methods. Periodic preventive examination was carried out for 2431 employees (1311 men and 1120 women) aged 20-65 years using a specially developed questionnaire, blood pressure measurement, anthropometry, total cholesterol test. Hypertensive men were assessed for preclinical manifestations of atherosclerosis by ultrasound duplex scanning of the carotid and femoral arteries.Results. Hypertensive men (BP ≥140/90 mmHg and/or taking antihypertensive drugs; n=176, mean age 43.5 years) were included in the study. An increase in the thickness of the intima-media complex in the carotid arteries was found in 22.2% (n=38) people, in the femoral arteries – in 34.1% (n=60) people, in both basins – in 16.5% (n= 29) man. Atherosclerotic plaques in the carotid arteries were found in 40.3% of people (n=71), and in the femoral arteries – in 34.7% (n=61) of people, in both pools – in 23.9% (n=42) of men.Conclusion. Ultrasound diagnostic using modern ultrasound scanners is a highly informative method for non-invasive diagnosis of atherosclerosis in the arteries of the carotid and femoral basins in employees of a large industrial enterprise with arterial hypertension in the conditions of the medical and sanitary department. Carrying out these diagnostic approaches is advisable when organizing periodic medical examinations in order to improve primary prevention, as well as to prevent the aggravation of the identified pathological process, reduce complications, improve quality and increase life expectancy.

Selective kappa-opioid receptor (KOR) agonists are considered a promising group of substances for developing opioid analgesics characterised with an original mechanism of action without the risk of respiratory depression and drug addiction. Previous studies identified a fluorophenyl derivative of imidazo[1,2-a]benzimidazole (RU-1205) with a KOR-based mechanism of analgesic action established in in vitro and in vivo experiments.The aim of the study was to assess the effect of 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-a]benzimidazole dihydrochloride on the level of DNA damage in rats after a single subcutaneous injection.Materials and methods. The study was conducted in adult white outbred laboratory rats of both sexes. DNA damage was estimated using the comet assay. The study involved a single subcutaneous injection of an aqueous solution of RU-1205 in three doses: 1, 10, and 100 mg/kg. The authors used intraperitoneal methyl methanesulfonate (40 mg per kg of animal body weight) as a positive control and 0.9% NaCl (100 μL per 100 g of animal body weight) as a negative control.Results. A single subcutaneous injection of RU-1205 to rats did not produce a significant dose-dependent increase in % tail DNA when compared with the state of the corresponding organ/tissue cell genome in negative control animals after normal saline administration at the same time points. In the negative control groups, % tail DNA in cells of various organs/tissues ranged from 1.83% to 3.82% (median values [25–75%]). On the contrary, the administration of 40 mg/kg of genotoxic methyl methanesulfonate led to an increase in damaged DNA in all studied organs and tissues when compared with negative control animals.Conclusions. The study of 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-a] benzimidazole dihydrochloride genotoxicity demonstrated that a single subcutaneous injection of 1, 10, or 100 mg/kg of RU-1205 to rats did not damage the cell genome of the studied organs.