15 results on '"Nøjgaard, Camilla"'
Search Results
2. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study
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Falconi, Massimo, Zou, Wen-Bin, Engjom, Trond, Ooi, Chee Y., Sutton, Robert, Frulloni, Luca, Neoptolemos, John, Wilcox, Charles, Miroslav, Vujasinovic, Trikudanathan, Guru, Liao, Zhuan, Hauge, Truls, Mössner, Joachim, Hoge, Chantal, Fockens, Paul, Mieog, Sven, Capurso, Gabriele, Cui, Yunfeng, de Madaria, Enrique, Distler, Marius, Aghdassi, Ali, Whitcomb, David C., Russell, Kylie, Beyer, Georg, Kunovsky, Lumír, Kwanten, Wilhelmus, Nava, Andrea Kazemi, Conlon, Kevin, Siriwardena, A.K., Paiella, Salvatore, Alconchel, Felipe, Marino, Marco Vito, de Meijer, Vincent E., Domingo, Carlos, Kleeff, Jorg, Lakshmanan, Aarti, Lie Chu, Michael Jen, Bouwense, Stefan, Nashidengo, Pueya Rashid, Konstantinos, Perivoliotis, Muttillo, Edoardo Maria, Umar, Garzali Ibrahim, Castro Santiago, Maria Jesus, Lopez-Lopez, Victor, Torri, Francesco, Schmelzle, Moritz, Ignatavicius, Povilas, Wicherts, Dennis, Gomes, Antonio, Machairas, Nikolaos A., Dorovinis, Panagiotis I., Serrablo, Alejandro, Soreide, Kjetil, Rahbari, Mohammad, Jie Chu, Michael Jen, Ptasnuka, Margarita, Petrulionis, Marius, Noel, Colin Byron, Castro, Ernest, Di Martino, Marcello, Recordare, Alfonso, Stättner, Stefan, Ausania, Fabio, Hartman, Vera, Roeyen, Geert, Egorov, Viacheslav, Vanagas, Tomas, Ebrahim, Mohamed, Arabadzhieva, Elena, Malleo, Giuseppe, Li, Liang, Adams, David, Oracz, Grzegorz, Nageshwar, Reddy D., Waldthaler, Alexander, Masamune, Atsushi, Drewes, Asbjorn Mohr, Amodio, Antonio, Tirkes, Temel, Srivastava, Anshu, Beilman, Gregory J., Berger, Zoltan, Lindkvist, Bjorn, Cavestro, Giulia Martina, Gariepy, Cheryl, Czakó, Laszlo, Di Leo, Milena, Sharma, Vishal, Lakhtakia, Sundeep, Rana, Surinder Singh, Duggan, Sinaed N., Kwon, Chang-Il, Phillips, Anna Evans, Forsmark, Christopher E., Gleeson, Ferga C., Lehman, Glen A., Greenhalf, William, Costamagna, Guido, Halloran, Christopher M., Friess, Helmut, Rasmussen, Henrik Hojgaard, Ikeura, Tsukasa, Haldorsen, Ingfrid S., Itoi, Takao, Izbicki, Jacob R., Windsor, John, Poulsen, Jakob Lykke, Frokjaer, Jens Brondum, Larino-Noia, Jose, Wang, Dan, Garcia, Julio Iglesias, Kalaitzakis, Evangelos, Wertheim-Tysarowska, Kararzyna, Kubota, Kensuke, Larusch, Jessica, Lerch, Markus M., Hu, Liang-Hao, Erkan, Mert, Machicado, Jorg D., Arvanitakis, Marianna, Buchler, Markus W., Levy, Marlon F., Heyman, Melvin B., Nojgaard, Camilla, Khashab, Mouen A., Delhaye, Myriam, Ogura, Takeshi, Okazaki, Kazuichi, Ghaneh, Paula, Banks, Peter A., Gupta, Pankaj, Papachristou, Georgios I., Michl, Patrick, Levy, Philippe, Pukitis, Aldis, Pezzilli, Raffaele, Baron, Ryan D., Amann, Stephen T., Schwarzenberg, Sarah Jane, Isaji, Shuiji, Olesen, Soren Schou, Novovic, Srdan, Hughes, Steven J., Werlin, Steven L., Gonska, Tanja, Gardner, Timothy B., Topazian, Mark D., Weiss, Frank Ulrich, Akshintala, Venakata S., Morinville, Veronique D., Rebours, Vinciane, Vincze, Aron, Singh, Vikesh K., Cui, Naiqiang, Zhang, Hong, Li, Zhao-shen, de Rijk, Florence E.M., van Veldhuisen, Charlotte L., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., van Geenen, Erwin J.M., Hegyi, Peter, Löhr, J-Matthias, Dominguez-Munoz, Juan E., de Jonge, Pieter Jan F., Bruno, Marco J., and Verdonk, Robert C.
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- 2022
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3. Exocrine pancreas insufficiency in chronic pancreatitis – Risk factors and associations with complications. A multicentre study of 1869 patients
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Erchinger, Friedemann, Engjom, Trond, Dimcevski, Georg, Drewes, Asbjørn M., Olesen, Søren Schou, Vujasinovic, Miroslav, Löhr, Johannes-Matthias, Nøjgaard, Camilla, Novovic, Srdan, Laukkarinen, Johanna, Parhiala, Mikael, Björn, Lindkvist, Waage, Anne, Hauge, Truls, Pukitis, Aldis, Ozola-Zalite, Imanta, Kalaitzakis, Evangelos, Okhlobystin, Alexey, Barauskas, Giederius, Eva Efsen, Dahl, and Tjora, Erling
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- 2022
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4. Social disparity is associated with an increased risk of acute and chronic pancreatitis.
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Becker, Ulrik, Timmermann, Amalie, Ekholm, Ola, Drewes, Asbjørn Mohr, Novovic, Srdan, Nøjgaard, Camilla, Olesen, Søren Schou, and Tolstrup, Janne Schurmann
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CHRONIC disease risk factors ,RISK assessment ,ACUTE diseases ,INCOME ,BODY mass index ,SOCIOECONOMIC disparities in health ,SOCIOECONOMIC factors ,FAMILIES ,PANCREATITIS ,LONGITUDINAL method ,SURVEYS ,ALCOHOL drinking ,CONFIDENCE intervals ,DIET ,EDUCATIONAL attainment ,DISEASE incidence ,DISEASE risk factors - Abstract
Aim To study social disparity in acute pancreatitis (AP) and chronic pancreatitis (CP).We also aimed at exploring whether an interaction exists between alcohol intake and socioeconomic factors. Methods Prospective cohort study based on data from 271 696 men and women participating in the Danish National Health Surveys 2010, and 2013. Information on alcohol and smoking parameters, body mass index (BMI), diet, and education, were self-reported and information on family income was obtained from administrative registers. Outcome variables (acute and chronic pancreatitis) were obtained from national health registers. Results The incidence rate ratio (IRR) of developing AP and CP increased with decreasing family income. Compared to participants in the highest income quintile, participants in the lowest income quintile had 43 (95% CI: 14–80%), 99 (95% CI: 26–214%), and 56% (95% CI: 26–94%) higher incidence rates of AP, CP, and all pancreatitis, respectively. The associations persisted after adjustment for alcohol intake, smoking, BMI, and diet. Likewise, participants with only primary school education had an IRR for an AP of 1.30 (95% CI: 1.06–1.59) compared to those with higher education after adjustment for baseline year, age, and sex. We found no interactions between alcohol intake and income or between alcohol intake and education in relation to neither AP, CP, nor all pancreatitis. Conclusion This large prospective population study showed a significant social disparity in incidence rates of pancreatitis by family income, with higher rates among those with the lowest income and education independent of risk factors such as alcohol intake, smoking, BMI, and diet. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Prospective comparison of diagnostic tests for bile acid diarrhoea
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Borup, Christian, primary, Vinter‐Jensen, Lars, additional, Jørgensen, Søren Peter German, additional, Wildt, Signe, additional, Graff, Jesper, additional, Gregersen, Tine, additional, Zaremba, Anna, additional, Andersen, Trine Borup, additional, Nøjgaard, Camilla, additional, Timm, Hans Bording, additional, Lamazière, Antonin, additional, Rainteau, Dominique, additional, Hansen, Svend Høime, additional, Rumessen, Jüri Johannes, additional, and Munck, Lars Kristian, additional
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- 2023
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6. Prospective comparison of diagnostic tests for bile acid diarrhoea.
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Borup, Christian, Vinter‐Jensen, Lars, Jørgensen, Søren Peter German, Wildt, Signe, Graff, Jesper, Gregersen, Tine, Zaremba, Anna, Andersen, Trine Borup, Nøjgaard, Camilla, Timm, Hans Bording, Lamazière, Antonin, Rainteau, Dominique, Hansen, Svend Høime, Rumessen, Jüri Johannes, and Munck, Lars Kristian
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BILE acids ,DIARRHEA ,DIAGNOSIS methods ,RECEIVER operating characteristic curves ,TREATMENT effectiveness ,ENTEROHEPATIC circulation - Abstract
Summary: Background: Bile acid diarrhoea is often missed because gold standard nuclear medicine tauroselcholic [75‐Se] acid (SeHCAT) testing has limited availability. Empirical treatment effect has unknown diagnostic performance, whereas plasma 7α‐hydroxy‐4‐cholesten‐3‐one (C4) is inexpensive but lacks sensitivity. Aims: To determine diagnostic characteristics of empirical treatment and explore improvements in diagnostics with potential better availability than SeHCAT. Methods: This diagnostic accuracy study was part of a randomised, placebo‐controlled trial of colesevelam. Consecutive patients with chronic diarrhoea attending SeHCAT had blood and stool sampled. Key thresholds were C4 > 46 ng/mL and SeHCAT retention ≤10%. A questionnaire recorded patient‐reported empirical treatment effect. We analysed receiver operating characteristics and explored machine learning applied logistic regression and decision tree modelling with internal validation. Results: Ninety‐six (38%) of 251 patients had SeHCAT retention ≤10%. The effect of empirical treatment assessed with test results for bile acid studies blinded had 63% (95% confidence interval 44%–79%) sensitivity and 65% (47%–80%) specificity; C4 > 46 ng/mL had 47% (37%–57%) and 92% (87%–96%), respectively. A decision tree combining C4 ≥ 31 ng/mL with ≥1.1 daily watery stools (Bristol type 6 and 7) had 70% (51%–85%) sensitivity and 95% (83%–99%) specificity. The logistic regression model, including C4, the sum of measured stool bile acids and daily watery stools, had 77% (58%–90%) sensitivity and 93% (80%–98%) specificity. Conclusions: Diagnosis of bile acid diarrhoea using empirical treatment was inadequate. Exploration suggested considerable improvements in the sensitivity of C4‐based testing, offering potential widely available diagnostics. Further validation is warranted. ClinicalTrials.gov: NCT03876717. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Alcohol Drinking Patterns and Risk of Developing Acute and Chronic Pancreatitis
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Becker, Ulrik, primary, Timmermann, Amalie, additional, Ekholm, Ola, additional, Grønbæk, Morten, additional, Drewes, Asbjørn Mohr, additional, Novovic, Srdan, additional, Nøjgaard, Camilla, additional, Olesen, Søren Schou, additional, and Tolstrup, Janne Schurmann, additional
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- 2023
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8. Alcohol Drinking Patterns and Risk of Developing Acute and Chronic Pancreatitis
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Becker, Ulrik, Timmermann, Amalie, Ekholm, Ola, Grønbæk, Morten, Drewes, Asbjørn Mohr, Novovic, Srdan, Nøjgaard, Camilla, Olesen, Søren Schou, Tolstrup, Janne Schurmann, Becker, Ulrik, Timmermann, Amalie, Ekholm, Ola, Grønbæk, Morten, Drewes, Asbjørn Mohr, Novovic, Srdan, Nøjgaard, Camilla, Olesen, Søren Schou, and Tolstrup, Janne Schurmann
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Aim: The aim was to analyze the effects of drinking pattern and type of alcohol on risk of acute and chronic pancreatitis. Methods: Prospective cohort study based on data from 316,751 men and women participating in the Danish National Health Surveys 2010 and 2013. Self-reported questionnaire-based alcohol parameters and information on pancreatitis was obtained from national health registers. Cox regression models were used adjusting for baseline year, gender, age, smoking, Body Mass Index, diet and education. Results: Development of acute and chronic pancreatitis increased with alcohol intake with a significant increase among abstainers and those drinking >14 drinks per week compared with individuals drinking 1-7 drinks per week. Frequent binge drinking and frequent drinking (every day) was associated with increased development of acute and chronic pancreatitis compared with those drinking 2-4 days per week. Problematic alcohol use according to the CAGE-C questionnaire was associated with increased development of acute and chronic pancreatitis. Intake of more than 14 drinks of spirits per week was associated with increased development of acute and chronic pancreatitis, and more than 14 drinks of beer per week were associated with increased development of chronic pancreatitis, whereas drinking wine was not associated with development of pancreatitis. Conclusion: This large prospective population study showed a J-shaped association between alcohol intake and development of pancreatitis. Drinking every day, frequent binge drinking and problematic alcohol use were associated with increased development of pancreatitis and drinking large amounts of beer and spirits might be more harmful than drinking wine.
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- 2023
9. Quality of life after endoscopic procedures for chronic pancreatitis: A multicentre study
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Parhiala, Mikael, Nøjgaard, Camilla, Bartholdy, Andreas, Waage, Anne, Ignatavičius, Povilas, Engjom, Trond, Dimcevski, Georg, Nordaas, Ingrid Kvåle, Kalaitzakis, Evangelos, Drewes, Asbjørn M., Hadi, Amer, Olesen, Søren S., Poulsen, Jakob L., and Laukkarinen, Johanna
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Chronic Pancreatitis (CP) causes morphological changes in the pancreatic tissue, leading to complications and pain, which may require endoscopic interventions. Our aim was to determine the frequency of endoscopic procedures (EP) in CP patients and to analyse pain and quality of life (QoL) in these patients after their EP. This study included 1327 CP patients from the Scandinavian Baltic Pancreatic Club (SBPC) database including four countries and eight centres. We analysed patients undergoing EPs and gathered information on the EP, pancreatic function, pain, disease and duration. The EORTC C‐30 QoL questionnaire was gathered prospectively and multivariable analysis was conducted on independent parameters between the groups. The reference population had no interventions (n= 870). 260 CP patients (22%) underwent EPs, median one year (range 0–39 years) after CP diagnosis. 68% were males. The median age was 59 (20–90) years. Most common aetiological factors were alcohol in 65% and smoking in 71%. Extracorporeal shock wave lithotripsy (ESWL) was used in 6% of the CP population and in 21% of the EP group. Biliary duct stenting was performed on 37% and pancreatic stenting was performed on 56% of the patients. There was no difference in pain patterns between patients who had pancreatic stenting and the reference population. The EP group had slightly better QoL (p= 0.047), functioning and fewer symptoms than the reference population, in the multivariable analysis there was no interaction effect analysis between the groups. The pancreatic stent group had better QoL and the same amount of pain than the reference group. The patients who needed later surgery (23%) had more pain (p= 0.043) and fatigue (p= 0.021). One in five of the CP patients underwent EP. These patients scored higher on QoL responses and had better symptom scores. CP patients who had pancreatic stenting performed had the same pain patterns as the reference population. Randomised prospective trials are needed to determine the effect of endoscopy procedures on CP patients.
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- 2023
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10. Surgical strategies for chronic pancreatitis in a 1,327- patient Scandinavian Baltic pancreatic Club (SBPC) register
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Parhiala, Mikael, primary, Waage, Anne, additional, Ignatavičius, Povilas, additional, Olesen, Søren S., additional, Poulsen, Jakob L., additional, Trond, Engjom, additional, Dimcevski, Georg, additional, Nordaas, Ingrid, additional, Hadi, Amer, additional, Kalaitzakis, Evangelos, additional, Drewes, Asbjørn M., additional, Nøjgaard, Camilla, additional, and Laukkarinen, Johanna, additional
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- 2023
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11. Pancreatic enzyme treatment in chronic pancreatitis: Quality of management and adherence to guidelines–A cross‐sectional observational study
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Erchinger, Friedemann, primary, Tjora, Erling, additional, Nordaas, Ingrid Kvåle, additional, Dimcevski, Georg, additional, Olesen, Søren Schou, additional, Jensen, Nanna, additional, Dahl, Eva Efsen, additional, Borch, Anders, additional, Nøjgaard, Camilla, additional, Novovic, Srdan, additional, Barauskas, Giedrus, additional, Ignatavicius, Povilas, additional, Vujasinovic, Miroslav, additional, Lőhr, Matthias, additional, Laukkarinen, Johanna, additional, Parhiala, Mikael, additional, Drewes, Asbjørn Mohr, additional, and Engjom, Trond, additional
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- 2022
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12. Long-term changes of pancreatic function in patients with complicated walled-off necrosis
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Nøjgaard, Camilla, primary, Werge, Mikkel, additional, Naver, Astrid, additional, Wilkens Knudsen, Anne, additional, Wewer Albrechtsen, Nicolai J., additional, Møller, Søren, additional, Gluud, Lise Lotte, additional, and Novovic, Srdan, additional
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- 2022
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13. Structural imaging findings are related to clinical complications in chronic pancreatitis
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Nordaas, Ingrid Kvåle, Tjora, Erling, Dimcevski, Georg, Haldorsen, Ingfrid S., Olesen, Søren Schou, Drewes, Asbjørn Mohr, Zviniene, Kristina, Barauskas, Giedrius, Bayram, Berivan Kyed, Nørregaard, Peter, Borch, Anders, Nøjgaard, Camilla, Jensen, Annette Bøjer, Kardasheva, Svetlana S., Okhlobystin, Alexey, Hauge, Truls, Waage, Anne, Frøkjær, Jens Brøndum, and Engjom, Trond
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Male ,Pancreatitis, Chronic/diagnosis ,Gastroenterology ,Pancreatic Diseases ,Middle Aged ,Atrophy/complications ,Exocrine Pancreatic Insufficiency/diagnostic imaging ,exocrine pancreatic insufficiency ,Abdominal Pain ,Cross-Sectional Studies ,Oncology ,underweight ,Pancreatitis, Chronic ,diabetes mellitus ,Diabetes Mellitus ,Humans ,Exocrine Pancreatic Insufficiency ,Female ,pain ,pancreas ,Atrophy ,Pancreas ,Abdominal Pain/diagnosis - Abstract
BACKGROUND/OBJECTIVES: Structural pancreatic changes and complications related to chronic pancreatitis are well described, but little is known about their relationship. We aimed to explore the associations between pancreatic morphology and clinical complications in a large chronic pancreatitis cohort.METHODS: The Scandinavian Baltic Pancreatic Club database collects registrations on patients with definite or probable chronic pancreatitis according to the M-ANNHEIM diagnostic criteria. In this cross-sectional study, we used multivariate logistic regression analyses to evaluate whether imaging-based structural pancreatic changes were associated with common clinical complications. We adjusted for sex, age, disease duration, current alcohol abuse and current smoking.RESULTS: We included 742 patients with a mean age of 55 years. Among these, 68% were males, 69% had pancreatic exocrine insufficiency, 35% had diabetes, 12% were underweighted and 68% reported abdominal pain. Main pancreatic duct obstruction, severe (i.e. more than 14) calcifications, pancreatic atrophy and parenchymal changes throughout the entire pancreas (continuous organ involvement) were positively associated with pancreatic exocrine insufficiency. Continuous organ involvement and pseudocysts were positively and negatively associated with diabetes, respectively. Pancreatic atrophy and severe calcifications were positively associated with underweight, and severe calcifications were negatively associated with pain.CONCLUSIONS: This study shows independent associations between distinct structural changes on pancreatic imaging and clinical complications in chronic pancreatitis. Pancreatic atrophy, severe calcifications and continuous organ involvement may be of particular clinical relevance, and these findings should motivate monitoring of pancreatic function and nutritional status.
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- 2022
14. Time trends in incidence and prevalence of chronic pancreatitis: A 25-year population-based nationwide study
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Olesen, Søren S, Mortensen, Laust H, Zinck, Elisabeth, Becker, Ulrik, Drewes, Asbjørn M, Nøjgaard, Camilla, Novovic, Srdan, Yadav, Dhiraj, and Tolstrup, Janne S
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Background Updated population-based estimates on incidence and prevalence of chronic pancreatitis are scarce.Methods We used nationwide healthcare registries to identify all Danish patients diagnosed with chronic pancreatitis and computed crude and standardised incidence rates and prevalence estimates in 1994–2018. Incidence and prevalence were evaluated in relation to patients age and gender, aetiology (alcoholic vs non-alcoholic) and smoking and alcohol consumption in the general Danish population.Results The mean incidence rate of chronic pancreatitis during the study period was 12.6 per 100,000 person years for the total population, for women it was 8.6 per 100,000 person years and for men it was 16.7 per 100,000 person years. The standardised incidence rate was stable from from 1994 through 2018, remaining at 12.5 per 100,000 person years in the last observation period (2014–2018). The point prevalence of chronic pancreatitis in 2016 was 153.9 per 100,000 persons. A gradual increase in standardised prevalence estimates was observed during the study period from 126.6 in 1996 to 153.9 in 2016. The mean age at chronic pancreatitis diagnosis increased from 52.1 to 60.0 years during the study period.Conclusion The prevalence of chronic pancreatitis is increasing in the Danish population despite a stable incidence level. Improved management strategies and changes in the underlying patient population may explain these observations.
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- 2024
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15. Structural imaging findings are related to clinical complications in chronic pancreatitis.
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Nordaas IK, Tjora E, Dimcevski G, Haldorsen IS, Olesen SS, Drewes AM, Zviniene K, Barauskas G, Bayram BK, Nørregaard P, Borch A, Nøjgaard C, Jensen AB, Kardasheva SS, Okhlobystin A, Hauge T, Waage A, Frøkjaer JB, and Engjom T
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- Abdominal Pain diagnosis, Abdominal Pain etiology, Atrophy complications, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Diabetes Mellitus, Exocrine Pancreatic Insufficiency diagnostic imaging, Exocrine Pancreatic Insufficiency epidemiology, Pancreatic Diseases, Pancreatitis, Chronic diagnosis, Pancreatitis, Chronic diagnostic imaging
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Background/objectives: Structural pancreatic changes and complications related to chronic pancreatitis are well described, but little is known about their relationship. We aimed to explore the associations between pancreatic morphology and clinical complications in a large chronic pancreatitis cohort., Methods: The Scandinavian Baltic Pancreatic Club database collects registrations on patients with definite or probable chronic pancreatitis according to the M-ANNHEIM diagnostic criteria. In this cross-sectional study, we used multivariate logistic regression analyses to evaluate whether imaging-based structural pancreatic changes were associated with common clinical complications. We adjusted for sex, age, disease duration, current alcohol abuse and current smoking., Results: We included 742 patients with a mean age of 55 years. Among these, 68% were males, 69% had pancreatic exocrine insufficiency, 35% had diabetes, 12% were underweighted and 68% reported abdominal pain. Main pancreatic duct obstruction, severe (i.e. more than 14) calcifications, pancreatic atrophy and parenchymal changes throughout the entire pancreas (continuous organ involvement) were positively associated with pancreatic exocrine insufficiency. Continuous organ involvement and pseudocysts were positively and negatively associated with diabetes, respectively. Pancreatic atrophy and severe calcifications were positively associated with underweight, and severe calcifications were negatively associated with pain., Conclusions: This study shows independent associations between distinct structural changes on pancreatic imaging and clinical complications in chronic pancreatitis. Pancreatic atrophy, severe calcifications and continuous organ involvement may be of particular clinical relevance, and these findings should motivate monitoring of pancreatic function and nutritional status., (© 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.)
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- 2022
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