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Your search keyword '"Murphy, Michelle M."' showing total 12 results
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12 results on '"Murphy, Michelle M."'

1. The Differential Translation Capabilities of the Human DHFR2 Gene Indicates a Developmental and Tissue-Specific Endogenous Protein of Low Abundance

Author

Bookey, Niamh, Drago, Paola, Leung, Kit-Yi, Hughes, Linda, MacCooey, Aoife, Ozaki, Mari, Henry, Michael, De Castro, Sandra C.P., Doykov, Ivan, Heywood, Wendy E., Mills, Kevin, Murphy, Michelle M., Cavallé-Busquets, Pere, Campbell, Susan, Burtenshaw, Denise, Meleady, Paula, Cahill, Paul A., Greene, Nicholas D.E., and Parle-McDermott, Anne

Published
2024
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4. Indicators of Cobalamin Status During Pregnancy, Pregnancy Outcome and Long-Term Effects on Offspring Health.

Author

Santos-Calderón, Luis Adolfo, Rojas-Gómez, Alejandra, Ramos-Rodríguez, Carla, and Murphy, Michelle M.

Abstract

Background: Little attention has been given to prenatal cobalamin insufficiency in settings where dietary cobalamin intake is presumed adequate, such as populations with habitual intake of foods from animal sources. Results: However, low cobalamin status in women of fertile age has been reported in Europe, United States, and Canada. In India, where cobalamin deficiency is highly prevalent, it has been associated with an increased risk of miscarriage, intrauterine growth retardation, as well as insulin resistance and lower neurodevelopment scores in the offspring. Low cobalamin status in pregnancy has been associated with similar outcomes as those reported in the Indian studies although the evidence is scant and conflicting. Conclusions: Consideration should be given to maternal cobalamin status in the context of prevention of adverse pregnancy outcomes as well as cobalamin insufficiency both in the mother and the offspring during lactation. Further attention is now justified with the increasing tendency toward plant-based diets. Reference intervals for cobalamin status during each trimester of pregnancy are needed and further investigation of the long-term conse-quences of low cobalamin status during pregnancy for health and development in the offspring is warranted. Plain language title: Inadequate cobalamin status during critical periods of growth and development can have negative consequences on maternal and childhood health [ABSTRACT FROM AUTHOR]

Published
2024
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5. Ultra-processed food consumption and semen quality parameters in the Led-Fertyl study

Author

Valle-Hita, Cristina, primary, Salas-Huetos, Albert, additional, Fernández de la Puente, María, additional, Martínez, María Ángeles, additional, Canudas, Silvia, additional, Palau-Galindo, Antoni, additional, Mestres, Cristina, additional, Manzanares, José María, additional, Murphy, Michelle M, additional, Marquès, Montse, additional, Salas-Salvadó, Jordi, additional, and Babio, Nancy, additional

Published
2024
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6. Indicators of Cobalamin Status During Pregnancy, Pregnancy Outcome and Long-Term Effects on Offspring Health

Author

Green, Ralph, Plattel, Clara, Santos-Calderón, Luis Adolfo, Rojas-Gómez, Alejandra, Ramos-Rodríguez, Carla, and Murphy, Michelle M.

Abstract

Background: Little attention has been given to prenatal cobalamin insufficiency in settings where dietary cobalamin intake is presumed adequate, such as populations with habitual intake of foods from animal sources.Results: However, low cobalamin status in women of fertile age has been reported in Europe, United States, and Canada. In India, where cobalamin deficiency is highly prevalent, it has been associated with an increased risk of miscarriage, intrauterine growth retardation, as well as insulin resistance and lower neurodevelopment scores in the offspring. Low cobalamin status in pregnancy has been associated with similar outcomes as those reported in the Indian studies although the evidence is scant and conflicting.Conclusions: Consideration should be given to maternal cobalamin status in the context of prevention of adverse pregnancy outcomes as well as cobalamin insufficiency both in the mother and the offspring during lactation. Further attention is now justified with the increasing tendency toward plant-based diets. Reference intervals for cobalamin status during each trimester of pregnancy are needed and further investigation of the long-term conse-quences of low cobalamin status during pregnancy for health and development in the offspring is warranted.

Published
2024
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8. Is telomere length a biomarker of sperm quality? A systematic review and meta‐analysis of observational studies.

Author

Fernández de la Puente, María, Salas‐Huetos, Albert, Valle‐Hita, Cristina, Babio, Nancy, Murphy, Michelle M., Canudas, Silvia, and Salas‐Salvadó, Jordi

Subjects
TELOMERES, SPERMATOZOA, SEMEN analysis, SCIENTIFIC observation, MALE infertility
Abstract

Background: Telomeres are essential for the integrity of chromosome ends during cell division and their involvement in different processes linked to aging has been established. These chromosome components are involved in spermatogenesis and seem to play an important role in fertilization and embryo development. Telomere length is shortened with each cell division. Recently, short sperm telomere length has been proposed as a potential biomarker of male infertility. Objectives: To conduct a systematic review and meta‐analysis of studies exploring the association between spermatozoa and/or leukocyte telomere length with sperm quality parameters and different infertility conditions. Material and methods: A systematic review and meta‐analysis was conducted with studies from Medline‐PUBMED and Cochrane Library databases until May 2022. Eligible studies included cohort, cross‐sectional and case–control studies, and telomere length in spermatozoa and/or leukocytes cells was defined as the exposure. Semen quality parameters or infertility conditions (e.g., oligozoospermia, asthenozoospermia, teratozoospermia, or other spermatogenic impairment combinations) were defined as the outcomes. Results: Twenty‐three observational studies were included. In the qualitative analysis, high heterogeneity was observed between studies regarding the associations between telomere length and semen parameters in different normozoospermic/fertile and oligozoospermic/infertile populations. In the meta‐analysis, spermatozoa and leukocyte telomere length were shorter in infertile individuals than in fertile individuals (mean difference [95% confidence interval]: –1.43 [–1.66 to –1.21], p‐value <0.001 and –1.67 [–2.02 to –1.31], p‐value <0.001, respectively). Moreover, in terms of sperm telomere length, these differences were also significant between individuals with a normal seminogram and individuals with a low quantity of spermatozoa in the ejaculate (–0.97 [–1.32, –0.61], p‐value <0.001). Conclusion: The current systematic review and meta‐analysis suggests the potential role of spermatozoa or leukocyte telomere length as a reliable biomarker of semen quality, which may help distinguish between infertility conditions beyond the routine semen analysis. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring

Author

Rojas-Gómez, Alejandra, primary, Solé-Navais, Pol, additional, Cavallé-Busquets, Pere, additional, Ornosa-Martin, Gemma, additional, Grifoll, Carme, additional, Ramos-Rodriguez, Carla, additional, Fernandez-Ballart, Joan, additional, Masana, Luis, additional, Ballesteros, Mónica, additional, Ueland, Per Magne, additional, and Murphy, Michelle M., additional

Published
2022
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10. Polyphenol intake and cardiovascular risk in the PREDIMED-Plus trial. A comparison of different risk equations

Author

Rubín-García, María, primary, Vitelli-Storelli, Facundo, additional, Toledo, Estefanía, additional, Castro-Barquero, Sara, additional, Tresserra-Rimbau, Anna, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Hernáez, Álvaro, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Bernal-López, M. Rosa, additional, Lapetra, José, additional, Serra-Majem, Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Álvarez-Álvarez, Laura, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Gea, Alfredo, additional, Manzanares, José María, additional, Sorlí, Jose V., additional, Schröder, Helmut, additional, Abete, Itziar, additional, Tojal-Sierra, Lucas, additional, Crespo-Oliva, Edelys, additional, González-Botella, Andrés, additional, Rayó, Elena, additional, García-Rios, Antonio, additional, Gómez-Pérez, Ana María, additional, Santos-Lozano, José Manuel, additional, Bartolomé Resano, Rafael, additional, Murphy, Michelle M., additional, Ortega-Azorin, Carolina, additional, Medrano, Casimira, additional, Zulet, María Ángeles, additional, Sorto-Sanchez, Carolina, additional, Babio, Nancy, additional, Fitó, Montserrat, additional, Lamuela-Raventós, Rosa María, additional, and Martín-Sánchez, Vicente, additional

Published
2022
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11. Ingesta de polifenoles y riesgo cardiovascular en el ensayo PREDIMED-Plus. Una comparación de diferentes ecuaciones de riesgo

Author

Rubín-García, María, primary, Vitelli-Storelli, Facundo, additional, Toledo, Estefanía, additional, Castro-Barquero, Sara, additional, Tresserra-Rimbau, Anna, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Hernáez, Álvaro, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Bernal-López, M. Rosa, additional, Lapetra, José, additional, Serra-Majem, Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Álvarez-Álvarez, Laura, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Gea, Alfredo, additional, Manzanares, José María, additional, Sorlí, Jose V., additional, Schröder, Helmut, additional, Abete, Itziar, additional, Tojal-Sierra, Lucas, additional, Crespo-Oliva, Edelys, additional, González-Botella, Andrés, additional, Rayó, Elena, additional, García-Rios, Antonio, additional, Gómez-Pérez, Ana María, additional, Santos-Lozano, José Manuel, additional, Bartolomé Resano, Rafael, additional, Murphy, Michelle M., additional, Ortega-Azorin, Carolina, additional, Medrano, Casimira, additional, Zulet, María Ángeles, additional, Sorto-Sanchez, Carolina, additional, Babio, Nancy, additional, Fitó, Monstserrat, additional, Lamuela-Raventós, Rosa María, additional, and Martín-Sánchez, Vicente, additional

Published
2022
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12. The Differential Translation Capabilities of the Human DHFR2Gene Indicates a Developmental and Tissue-Specific Endogenous Protein of Low Abundance

Author

Bookey, Niamh, Drago, Paola, Leung, Kit-Yi, Hughes, Linda, MacCooey, Aoife, Ozaki, Mari, Henry, Michael, De Castro, Sandra C.P., Doykov, Ivan, Heywood, Wendy E., Mills, Kevin, Murphy, Michelle M., Cavallé-Busquets, Pere, Campbell, Susan, Burtenshaw, Denise, Meleady, Paula, Chill, Paul A., Greene, Nicholas D.E., and Parle-McDermott, Anne

Abstract

A functional role has been ascribed to the human dihydrofolate reductase 2 (DHFR2) gene based on the enzymatic activity of recombinant versions of the predicted translated protein. However, the in vivofunction is still unclear. The high amino acid sequence identity (92%) between DHFR2 and its parental homolog, DHFR, makes analysis of the endogenous protein challenging. This paper describes a targeted mass spectrometry proteomics approach in several human cell lines and tissue types to identify DHFR2-specific peptides as evidence of its translation. We show definitive evidence that the DHFR2 activity in the mitochondria is in fact mediated by DHFR, and not DHFR2. Analysis of Ribo-seq data and an experimental assessment of ribosome association using a sucrose cushion showed that the two main Ensembl annotated mRNA isoforms of DHFR2, 201 and 202, are differentially associated with the ribosome. This indicates a functional role at both the RNA and protein level. However, we were unable to detect DHFR2 protein at a detectable level in most cell types examined despite various RNA isoforms of DHFR2 being relatively abundant. We did detect a DHFR2-specific peptide in embryonic heart, indicating that the protein may have a specific role during embryogenesis. We propose that the main functionality of the DHFR2gene in adult cells is likely to arise at the RNA level.

Published
2024
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