1. HbA1c variability associated with dementia risk in people with type 2 diabetes.
- Author
-
Moran, Chris, Whitmer, Rachel, Dove, Zoe, Lacy, Mary, Soh, Yenee, Tsai, Ai-Lin, Quesenberry, Charles, Karter, Andrew, Adams, Alyce, and Gilsanz, Paola
- Subjects
dementia ,diabetes ,glycemic control ,glycosylated hemoglobin A1c variability ,Humans ,Diabetes Mellitus ,Type 2 ,Female ,Glycated Hemoglobin ,Male ,Dementia ,Middle Aged ,Aged ,Risk Factors ,Blood Glucose - Abstract
INTRODUCTION: Although poor glycemic control is associated with dementia, it is unknown if variability in glycemic control, even in those with optimal glycosylated hemoglobin A1c (HbA1c) levels, increases dementia risk. METHODS: Among 171,964 people with type 2 diabetes, we evaluated the hazard of dementia association with long-term HbA1c variability using five operationalizations, including standard deviation (SD), adjusting for demographics and comorbidities. RESULTS: The mean baseline age was 61 years (48% women). Greater HbA1c SD was associated with greater dementia hazard (adjusted hazard ratio = 1.15 [95% confidence interval: 1.12, 1.17]). In stratified analyses, higher HbA1c SD quintiles were associated with greater dementia hazard among those with a mean HbA1c
- Published
- 2024