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1. The PLATO Mission

Author

Rauer, Heike, Aerts, Conny, Cabrera, Juan, Deleuil, Magali, Erikson, Anders, Gizon, Laurent, Goupil, Mariejo, Heras, Ana, Lorenzo-Alvarez, Jose, Marliani, Filippo, Martin-Garcia, Cesar, Mas-Hesse, J. Miguel, O'Rourke, Laurence, Osborn, Hugh, Pagano, Isabella, Piotto, Giampaolo, Pollacco, Don, Ragazzoni, Roberto, Ramsay, Gavin, Udry, Stéphane, Appourchaux, Thierry, Benz, Willy, Brandeker, Alexis, Güdel, Manuel, Janot-Pacheco, Eduardo, Kabath, Petr, Kjeldsen, Hans, Min, Michiel, Santos, Nuno, Smith, Alan, Suarez, Juan-Carlos, Werner, Stephanie C., Aboudan, Alessio, Abreu, Manuel, Acuña, Lorena, Adams, Moritz, Adibekyan, Vardan, Affer, Laura, Agneray, François, Agnor, Craig, Børsen-Koch, Victor Aguirre, Ahmed, Saad, Aigrain, Suzanne, Al-Bahlawan, Ashraf, Gil, M de los Angeles Alcacera, Alei, Eleonora, Alencar, Silvia, Alexander, Richard, Alfonso-Garzón, Julia, Alibert, Yann, Prieto, Carlos Allende, Almeida, Leonardo, Sobrino, Roi Alonso, Altavilla, Giuseppe, Althaus, Christian, Trujillo, Luis Alonso Alvarez, Amarsi, Anish, Eiff, Matthias Ammler-von, Amôres, Eduardo, Andrade, Laerte, Antoniadis-Karnavas, Alexandros, António, Carlos, del Moral, Beatriz Aparicio, Appolloni, Matteo, Arena, Claudio, Armstrong, David, Aliaga, Jose Aroca, Asplund, Martin, Audenaert, Jeroen, Auricchio, Natalia, Avelino, Pedro, Baeke, Ann, Baillié, Kevin, Balado, Ana, Balestra, Andrea, Ball, Warrick, Ballans, Herve, Ballot, Jerome, Barban, Caroline, Barbary, Gaële, Barbieri, Mauro, Forteza, Sebastià Barceló, Barker, Adrian, Barklem, Paul, Barnes, Sydney, Navascues, David Barrado, Barragan, Oscar, Baruteau, Clément, Basu, Sarbani, Baudin, Frederic, Baumeister, Philipp, Bayliss, Daniel, Bazot, Michael, Beck, Paul G., Bedding, Tim, Belkacem, Kevin, Bellinger, Earl, Benatti, Serena, Benomar, Othman, Bérard, Diane, Bergemann, Maria, Bergomi, Maria, Bernardo, Pierre, Biazzo, Katia, Bignamini, Andrea, Bigot, Lionel, Billot, Nicolas, Binet, Martin, Biondi, David, Biondi, Federico, Birch, Aaron C., Bitsch, Bertram, Ceballos, Paz Victoria Bluhm, Bódi, Attila, Bognár, Zsófia, Boisse, Isabelle, Bolmont, Emeline, Bonanno, Alfio, Bonavita, Mariangela, Bonfanti, Andrea, Bonfils, Xavier, Bonito, Rosaria, Bonomo, Aldo Stefano, Börner, Anko, Saikia, Sudeshna Boro, Martín, Elisa Borreguero, Borsa, Francesco, Borsato, Luca, Bossini, Diego, Bouchy, Francois, Boué, Gwenaël, Boufleur, Rodrigo, Boumier, Patrick, Bourrier, Vincent, Bowman, Dominic M., Bozzo, Enrico, Bradley, Louisa, Bray, John, Bressan, Alessandro, Breton, Sylvain, Brienza, Daniele, Brito, Ana, Brogi, Matteo, Brown, Beverly, Brown, David, Brun, Allan Sacha, Bruno, Giovanni, Bruns, Michael, Buchhave, Lars A., Bugnet, Lisa, Buldgen, Gaël, Burgess, Patrick, Busatta, Andrea, Busso, Giorgia, Buzasi, Derek, Caballero, José A., Cabral, Alexandre, Calderone, Flavia, Cameron, Robert, Cameron, Andrew, Campante, Tiago, Martins, Bruno Leonardo Canto, Cara, Christophe, Carone, Ludmila, Carrasco, Josep Manel, Casagrande, Luca, Casewell, Sarah L., Cassisi, Santi, Castellani, Marco, Castro, Matthieu, Catala, Claude, Fernández, Irene Catalán, Catelan, Márcio, Cegla, Heather, Cerruti, Chiara, Cessa, Virginie, Chadid, Merieme, Chaplin, William, Charpinet, Stephane, Chiappini, Cristina, Chiarucci, Simone, Chiavassa, Andrea, Chinellato, Simonetta, Chirulli, Giovanni, Christensen-Dalsgaard, Jorgen, Church, Ross, Claret, Antonio, Clarke, Cathie, Claudi, Riccardo, Clermont, Lionel, Coelho, Hugo, Coelho, Joao, Cogato, Fabrizio, Colomé, Josep, Condamin, Mathieu, Conseil, Simon, Corbard, Thierry, Correia, Alexandre C. M., Corsaro, Enrico, Cosentino, Rosario, Costes, Jean, Cottinelli, Andrea, Covone, Giovanni, Creevey, Orlagh L., Crida, Aurelien, Csizmadia, Szilard, Cunha, Margarida, Curry, Patrick, da Costa, Jefferson, da Silva, Francys, Dalal, Shweta, Damasso, Mario, Damiani, Cilia, Damiani, Francesco, Chagas, Maria Liduina das, Davies, Melvyn, Davies, Guy, Davies, Ben, Davison, Gary, de Almeida, Leandro, de Angeli, Francesca, de Barros, Susana Cristina Cabral, Leão, Izan de Castro, de Freitas, Daniel Brito, de Freitas, Marcia Cristina, De Martino, Domitilla, de Medeiros, José Renan, de Paula, Luiz Alberto, de Plaa, Jelle, De Ridder, Joris, Deal, Morgan, Decin, Leen, Deeg, Hans, Degl'Innocenti, Scilla, Deheuvels, Sebastien, del Burgo, Carlos, Del Sordo, Fabio, Delgado-Mena, Elisa, Demangeon, Olivier, Denk, Tilmann, Derekas, Aliz, Desidera, Silvano, Dexet, Marc, Di Criscienzo, Marcella, Di Giorgio, Anna Maria, Di Mauro, Maria Pia, Rial, Federico Jose Diaz, Díaz-García, José-Javier, Dima, Marco, Dinuzzi, Giacomo, Dionatos, Odysseas, Distefano, Elisa, Nascimento Jr., Jose-Dias do, Domingo, Albert, D'Orazi, Valentina, Dorn, Caroline, Doyle, Lauren, Duarte, Elena, Ducellier, Florent, Dumaye, Luc, Dumusque, Xavier, Dupret, Marc-Antoine, Eggenberger, Patrick, Ehrenreich, David, Eigmüller, Philipp, Eising, Johannes, Emilio, Marcelo, Eriksson, Kjell, Ermocida, Marco, Giribaldi, Riano Isidoro Escate, Eschen, Yoshi, Estrela, Inês, Evans, Dafydd Wyn, Fabbian, Damian, Fabrizio, Michele, Faria, João Pedro, Farina, Maria, Farinato, Jacopo, Feliz, Dax, Feltzing, Sofia, Fenouillet, Thomas, Ferrari, Lorenza, Ferraz-Mello, Sylvio, Fialho, Fabio, Fienga, Agnes, Figueira, Pedro, Fiori, Laura, Flaccomio, Ettore, Focardi, Mauro, Foley, Steve, Fontignie, Jean, Ford, Dominic, Fornazier, Karin, Forveille, Thierry, Fossati, Luca, Franca, Rodrigo de Marca, da Silva, Lucas Franco, Frasca, Antonio, Fridlund, Malcolm, Furlan, Marco, Gabler, Sarah-Maria, Gaido, Marco, Gallagher, Andrew, Galli, Emanuele, Garcia, Rafael A., Hernández, Antonio García, Munoz, Antonio Garcia, García-Vázquez, Hugo, Haba, Rafael Garrido, Gaulme, Patrick, Gauthier, Nicolas, Gehan, Charlotte, Gent, Matthew, Georgieva, Iskra, Ghigo, Mauro, Giana, Edoardo, Gill, Samuel, Girardi, Leo, Winter, Silvia Giuliatti, Giusi, Giovanni, da Silva, João Gomes, Zazo, Luis Jorge Gómez, Gomez-Lopez, Juan Manuel, Hernández, Jonay Isai González, Murillo, Kevin Gonzalez, Gorius, Nicolas, Gouel, Pierre-Vincent, Goulty, Duncan, Granata, Valentina, Grenfell, John Lee, Grießbach, Denis, Grolleau, Emmanuel, Grouffal, Salomé, Grziwa, Sascha, Guarcello, Mario Giuseppe, Gueguen, Loïc, Guenther, Eike Wolf, Guilhem, Terrasa, Guillerot, Lucas, Guiot, Pierre, Guterman, Pascal, Gutiérrez, Antonio, Gutiérrez-Canales, Fernando, Hagelberg, Janis, Haldemann, Jonas, Hall, Cassandra, Handberg, Rasmus, Harrison, Ian, Harrison, Diana L., Hasiba, Johann, Haswell, Carole A., Hatalova, Petra, Hatzes, Artie, Haywood, Raphaelle, Hébrard, Guillaume, Heckes, Frank, Heiter, Ulrike, Hekker, Saskia, Heller, René, Helling, Christiane, Helminiak, Krzysztof, Hemsley, Simon, Heng, Kevin, Hermans, Aline, Hermes, JJ, Torres, Nadia Hidalgo, Hinkel, Natalie, Hobbs, David, Hodgkin, Simon, Hofmann, Karl, Hojjatpanah, Saeed, Houdek, Günter, Huber, Daniel, Huesler, Joseph, Hui-Bon-Hoa, Alain, Huygen, Rik, Huynh, Duc-Dat, Iro, Nicolas, Irwin, Jonathan, Irwin, Mike, Izidoro, André, Jacquinod, Sophie, Jannsen, Nicholas Emborg, Janson, Markus, Jeszenszky, Harald, Jiang, Chen, Mancebo, Antonio José Jimenez, Jofre, Paula, Johansen, Anders, Johnston, Cole, Jones, Geraint, Kallinger, Thomas, Kálmán, Szilárd, Kanitz, Thomas, Karjalainen, Marie, Karjalainen, Raine, Karoff, Christoffer, Kawaler, Steven, Kawata, Daisuke, Keereman, Arnoud, Keiderling, David, Kennedy, Tom, Kenworthy, Matthew, Kerschbaum, Franz, Kidger, Mark, Kiefer, Flavien, Kintziger, Christian, Kislyakova, Kristina, Kiss, László, Klagyivik, Peter, Klahr, Hubert, Klevas, Jonas, Kochukhov, Oleg, Köhler, Ulrich, Kolb, Ulrich, Koncz, Alexander, Korth, Judith, Kostogryz, Nadiia, Kovács, Gábor, Kovács, József, Kozhura, Oleg, Krivova, Natalie, Kučinskas, Arunas, Kuhlemann, Ilyas, Kupka, Friedrich, Laauwen, Wouter, Labiano, Alvaro, Lagarde, Nadege, Laget, Philippe, Laky, Gunter, Lam, Kristine Wai Fun, Lambrechts, Michiel, Lammer, Helmut, Lanza, Antonino Francesco, Lanzafame, Alessandro, Martiz, Mariel Lares, Laskar, Jacques, Latter, Henrik, Lavanant, Tony, Lawrenson, Alastair, Lazzoni, Cecilia, Lebre, Agnes, Lebreton, Yveline, Etangs, Alain Lecavelier des, Leinhardt, Zoe, Leleu, Adrien, Lendl, Monika, Leto, Giuseppe, Levillain, Yves, Libert, Anne-Sophie, Lichtenberg, Tim, Ligi, Roxanne, Lignieres, Francois, Lillo-Box, Jorge, Linsky, Jeffrey, Liu, John Scige, Loidolt, Dominik, Longval, Yuying, Lopes, Ilídio, Lorenzani, Andrea, Ludwig, Hans-Guenter, Lund, Mikkel, Lundkvist, Mia Sloth, Luri, Xavier, Maceroni, Carla, Madden, Sean, Madhusudhan, Nikku, Maggio, Antonio, Magliano, Christian, Magrin, Demetrio, Mahy, Laurent, Maibaum, Olaf, Malac-Allain, LeeRoy, Malapert, Jean-Christophe, Malavolta, Luca, Maldonado, Jesus, Mamonova, Elena, Manchon, Louis, Mann, Andrew, Mantovan, Giacomo, Marafatto, Luca, Marconi, Marcella, Mardling, Rosemary, Marigo, Paola, Marinoni, Silvia, Marques, Érico, Marques, Joao Pedro, Marrese, Paola Maria, Marshall, Douglas, Perales, Silvia Martínez, Mary, David, Marzari, Francesco, Masana, Eduard, Mascher, Andrina, Mathis, Stéphane, Mathur, Savita, Figueiredo, Ana Carolina Mattiuci, Maxted, Pierre F. L., Mazeh, Tsevi, Mazevet, Stephane, Mazzei, Francesco, McCormac, James, McMillan, Paul, Menou, Lucas, Merle, Thibault, Meru, Farzana, Mesa, Dino, Messina, Sergio, Mészáros, Szabolcs, Meunier, Nadége, Meunier, Jean-Charles, Micela, Giuseppina, Michaelis, Harald, Michel, Eric, Michielsen, Mathias, Michtchenko, Tatiana, Miglio, Andrea, Miguel, Yamila, Milligan, David, Mirouh, Giovanni, Mitchell, Morgan, Moedas, Nuno, Molendini, Francesca, Molnár, László, Mombarg, Joey, Montalban, Josefina, Montalto, Marco, Monteiro, Mário J. P. F. G., Morales, Juan Carlos, Morales-Calderon, Maria, Morbidelli, Alessandro, Mordasini, Christoph, Moreau, Chrystel, Morel, Thierry, Morello, Guiseppe, Morin, Julien, Mortier, Annelies, Mosser, Benoît, Mourard, Denis, Mousis, Olivier, Moutou, Claire, Mowlavi, Nami, Moya, Andrés, Muehlmann, Prisca, Muirhead, Philip, Munari, Matteo, Musella, Ilaria, Mustill, Alexander James, Nardetto, Nicolas, Nardiello, Domenico, Narita, Norio, Nascimbeni, Valerio, Nash, Anna, Neiner, Coralie, Nelson, Richard P., Nettelmann, Nadine, Nicolini, Gianalfredo, Nielsen, Martin, Niemi, Sami-Matias, Noack, Lena, Noels-Grotsch, Arlette, Noll, Anthony, Norazman, Azib, Norton, Andrew J., Nsamba, Benard, Ofir, Aviv, Ogilvie, Gordon, Olander, Terese, Olivetto, Christian, Olofsson, Göran, Ong, Joel, Ortolani, Sergio, Oshagh, Mahmoudreza, Ottacher, Harald, Ottensamer, Roland, Ouazzani, Rhita-Maria, Paardekooper, Sijme-Jan, Pace, Emanuele, Pajas, Miriam, Palacios, Ana, Palandri, Gaelle, Palle, Enric, Paproth, Carsten, Parro, Vanderlei, Parviainen, Hannu, Granado, Javier Pascual, Passegger, Vera Maria, Pastor-Morales, Carmen, Pätzold, Martin, Pedersen, May Gade, Hidalgo, David Pena, Pepe, Francesco, Pereira, Filipe, Persson, Carina M., Pertenais, Martin, Peter, Gisbert, Petit, Antoine C., Petit, Pascal, Pezzuto, Stefano, Pichierri, Gabriele, Pietrinferni, Adriano, Pinheiro, Fernando, Pinsonneault, Marc, Plachy, Emese, Plasson, Philippe, Plez, Bertrand, Poppenhaeger, Katja, Poretti, Ennio, Portaluri, Elisa, Portell, Jordi, de Mello, Gustavo Frederico Porto, Poyatos, Julien, Pozuelos, Francisco J., Moroni, Pier Giorgio Prada, Pricopi, Dumitru, Prisinzano, Loredana, Quade, Matthias, Quirrenbach160, ndreas, Reina6, Julio Arturo Rabanal, Soares, Maria Cristina Rabello, Raimondo, Gabriella, Rainer, Monica, Rodón, Jose Ramón, Ramón-Ballesta, Alejandro, Zapata, Gonzalo Ramos, Rätz, Stefanie, Rauterberg, Christoph, Redman, Bob, Redmer, Ronald, Reese, Daniel, Regibo, Sara, Reiners, Ansgar, Reinhold, Timo, Renie, Christian, Ribas, Ignasi, Ribeiro, Sergio, Ricciardi, Thiago Pereira, Rice, Ken, Richard, Olivier, Riello, Marco, Rieutord, Michel, Ripepi, Vincenzo, Rixon, Guy, Rockstein, Steve, Rodríguez, María Teresa Rodrigo, Díaz, Luisa Fernanda Rodríguez, Garcia, Juan Pablo Rodriguez, Rodriguez-Gomez, Julio, Roehlly, Yannick, Roig, Fernando, Rojas-Ayala, Bárbara, Rolf, Tobias, Rørsted, Jakob Lysgaard, Rosado, Hugo, Rosotti, Giovanni, Roth, Olivier, Roth, Markus, Rousseau, Alex, Roxburgh, Ian, Roy, Fabrice, Royer, Pierre, Ruane, Kirk, Mastropasqua, Sergio Rufini, de Galarreta, Claudia Ruiz, Russi, Andrea, Saar, Steven, Saillenfest, Melaine, Salaris, Maurizio, Salmon, Sebastien, Saltas, Ippocratis, Samadi, Réza, Samadi, Aunia, Samra, Dominic, da Silva, Tiago Sanches, Carrasco, Miguel Andrés Sánchez, Santerne, Alexandre, Santoli, Francesco, Santos, Ângela R. G., Mesa, Rosario Sanz, Sarro, Luis Manuel, Scandariato, Gaetano, Schäfer, Martin, Schlafly, Edward, Schmider, François-Xavier, Schneider, Jean, Schou, Jesper, Schunker, Hannah, Schwarzkopf, Gabriel Jörg, Serenelli, Aldo, Seynaeve, Dries, Shan, Yutong, Shapiro, Alexander, Shipman, Russel, Sicilia, Daniela, Sanmartin, Maria Angeles Sierra, Sigot, Axelle, Silliman, Kyle, Silvotti, Roberto, Simon, Attila E., Napoli, Ricardo Simoyama, Skarka, Marek, Smalley, Barry, Smiljanic, Rodolfo, Smit, Samuel, Smith, Alexis, Smith, Leigh, Snellen, Ignas, Sódor, Ádám, Sohl, Frank, Solanki, Sami K., Sortino, Francesca, Sousa, Sérgio, Southworth, John, Souto, Diogo, Sozzetti, Alessandro, Stamatellos, Dimitris, Stassun, Keivan, Steller, Manfred, Stello, Dennis, Stelzer, Beate, Stiebeler, Ulrike, Stokholm, Amalie, Storelvmo, Trude, Strassmeier, Klaus, Strøm, Paul Anthony, Strugarek, Antoine, Sulis, Sophia, Švanda, Michal, Szabados, László, Szabó, Róbert, Szabó, Gyula M., Szuszkiewicz, Ewa, Talens, Geert Jan, Teti, Daniele, Theisen, Tom, Thévenin, Frédéric, Thoul, Anne, Tiphene, Didier, Titz-Weider, Ruth, Tkachenko, Andrew, Tomecki, Daniel, Tonfat, Jorge, Tosi, Nicola, Trampedach, Regner, Traven, Gregor, Triaud, Amaury, Trønnes, Reidar, Tsantaki, Maria, Tschentscher, Matthias, Turin, Arnaud, Tvaruzka, Adam, Ulmer, Bernd, Ulmer-Moll, Solène, Ulusoy, Ceren, Umbriaco, Gabriele, Valencia, Diana, Valentini, Marica, Valio, Adriana, Guijarro, Ángel Luis Valverde, Van Eylen, Vincent, Van Grootel, Valerie, van Kempen, Tim A., Van Reeth, Timothy, Van Zelst, Iris, Vandenbussche, Bart, Vasiliou, Konstantinos, Vasilyev, Valeriy, de Mascarenhas, David Vaz, Vazan, Allona, Nunez, Marina Vela, Velloso, Eduardo Nunes, Ventura, Rita, Ventura, Paolo, Venturini, Julia, Trallero, Isabel Vera, Veras, Dimitri, Verdugo, Eva, Verma, Kuldeep, Vibert, Didier, Martinez, Tobias Vicanek, Vida, Krisztián, Vigan, Arthur, Villacorta, Antonio, Villaver, Eva, Aparicio, Marcos Villaverde, Viotto, Valentina, Vorobyov, Eduard, Vorontsov, Sergey, Wagner, Frank W., Walloschek, Thomas, Walton, Nicholas, Walton, Dave, Wang, Haiyang, Waters, Rens, Watson, Christopher, Wedemeyer, Sven, Weeks, Angharad, Weingril, Jörg, Weiss, Annita, Wendler, Belinda, West, Richard, Westerdorff, Karsten, Westphal, Pierre-Amaury, Wheatley, Peter, White, Tim, Whittaker, Amadou, Wickhusen, Kai, Wilson, Thomas, Windsor, James, Winter, Othon, Winther, Mark Lykke, Winton, Alistair, Witteck, Ulrike, Witzke, Veronika, Woitke, Peter, Wolter, David, Wuchterl, Günther, Wyatt, Mark, Yang, Dan, Yu, Jie, Sanchez, Ricardo Zanmar, Osorio, María Rosa Zapatero, Zechmeister, Mathias, Zhou, Yixiao, Ziemke, Claas, and Zwintz, Konstanze

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

PLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2 R_(Earth)) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5 %, 10 %, 10 % for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, the mission will perform high-precision photometric measurements. Here we review the science objectives, present PLATO's target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile at the beginning of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases.

Published
2024

2. Expanding the frontiers of cool-dwarf asteroseismology with ESPRESSO. Detection of solar-like oscillations in the K5 dwarf $\epsilon$ Indi

Author

Campante, T. L., Kjeldsen, H., Li, Y., Lund, M. N., Silva, A. M., Corsaro, E., da Silva, J. Gomes, Martins, J. H. C., Adibekyan, V., Silva, T. Azevedo, Bedding, T. R., Bossini, D., Buzasi, D. L., Chaplin, W. J., Costa, R. R., Cunha, M. S., Cristo, E., Faria, J. P., García, R. A., Huber, D., Lundkvist, M. S., Metcalfe, T. S., Monteiro, M. J. P. F. G., Neitzel, A. W., Nielsen, M. B., Poretti, E., Santos, N. C., and Sousa, S. G.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

Fuelled by space photometry, asteroseismology is vastly benefitting the study of cool main-sequence stars, which exhibit convection-driven solar-like oscillations. Even so, the tiny oscillation amplitudes in K dwarfs continue to pose a challenge to space-based asteroseismology. A viable alternative is offered by the lower stellar noise over the oscillation timescales in Doppler observations. In this letter we present the definite detection of solar-like oscillations in the bright K5 dwarf $\epsilon$ Indi based on time-intensive observations collected with the ESPRESSO spectrograph at the VLT, thus making it the coolest seismic dwarf ever observed. We measured the frequencies of a total of 19 modes of degree $\ell=0$--2 along with $\nu_{\rm max}=5305\pm176\:{\rm \mu Hz}$ and $\Delta\nu=201.25\pm0.16\:{\rm \mu Hz}$. The peak amplitude of radial modes is $2.6\pm0.5\:{\rm cm\,s^{-1}}$, or a mere ${\sim} 14\%$ of the solar value. Measured mode amplitudes are ${\sim} 2$ times lower than predicted from a nominal $L/M$ scaling relation and favour a scaling closer to $(L/M)^{1.5}$ below ${\sim} 5500\:{\rm K}$, carrying important implications for our understanding of the coupling efficiency between pulsations and near-surface convection in K dwarfs. This detection conclusively shows that precise asteroseismology of cool dwarfs is possible down to at least the mid-K regime using next-generation spectrographs on large-aperture telescopes, effectively opening up a new domain in observational asteroseismology., Comment: Accepted for publication in Astronomy & Astrophysics Letters

Published
2024
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3. Revisiting the Red-giant Branch Hosts KOI-3886 and $\iota$ Draconis. Detailed Asteroseismic Modeling and Consolidated Stellar Parameters

Author

Campante, Tiago L., Li, Tanda, Ong, J. M. Joel, Corsaro, Enrico, Cunha, Margarida S., Bedding, Timothy R., Bossini, Diego, Breton, Sylvain N., Buzasi, Derek L., Chaplin, William J., Deal, Morgan, García, Rafael A., Hill, Michelle L., Hon, Marc, Huber, Daniel, Jiang, Chen, Kane, Stephen R., Kayhan, Cenk, Kuszlewicz, James S., Lillo-Box, Jorge, Mathur, Savita, Monteiro, Mário J. P. F. G., Pereira, Filipe, Santos, Nuno C., Serenelli, Aldo, and Stello, Dennis

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

Asteroseismology is playing an increasingly important role in the characterization of red-giant host stars and their planetary systems. Here, we conduct detailed asteroseismic modeling of the evolved red-giant branch (RGB) hosts KOI-3886 and $\iota$ Draconis, making use of end-of-mission Kepler (KOI-3886) and multi-sector TESS ($\iota$ Draconis) time-series photometry. We also model the benchmark star KIC 8410637, a member of an eclipsing binary, thus providing a direct test to the seismic determination. We test the impact of adopting different sets of observed modes as seismic constraints. Inclusion of $\ell=1$ and 2 modes improves the precision on the stellar parameters, albeit marginally, compared to adopting radial modes alone, with $1.9$-$3.0\%$ (radius), $5$-$9\%$ (mass), and $19$-$25\%$ (age) reached when using all p-dominated modes as constraints. Given the very small spacing of adjacent dipole mixed modes in evolved RGB stars, the sparse set of observed g-dominated modes is not able to provide extra constraints, further leading to highly multimodal posteriors. Access to multi-year time-series photometry does not improve matters, with detailed modeling of evolved RGB stars based on (lower-resolution) TESS data sets attaining a precision commensurate with that based on end-of-mission Kepler data. Furthermore, we test the impact of varying the atmospheric boundary condition in our stellar models. We find mass and radius estimates to be insensitive to the description of the near-surface layers, at the expense of substantially changing both the near-surface structure of the best-fitting models and the values of associated parameters like the initial helium abundance, $Y_{\rm i}$. Attempts to measure $Y_{\rm i}$ from seismic modeling of red giants may thus be systematically dependent on the choice of atmospheric physics., Comment: Accepted for publication in The Astronomical Journal (AJ)

Published
2023
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4. Glitches in solar-like oscillating F-type stars: Theoretical signature of the base of the convective envelope on the ratios $r_{010}$

Author

Deal, M., Goupil, M. -J., Cunha, M. S., Monteiro, M. J. P. F. G., Lebreton, Y., Christophe, S., Pereira, F., Samadi, R., Oreshina, A. V., and Buldgen, G.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The transition between convective and radiative stellar regions is still not fully understood. The sharp variations in sound speed located in these transition regions give rise to a signature in specific seismic indicators, opening the possibility to constrain the physics of convection to radiation transition. Among those seismic indicators, the ratios of the small to large frequency separation for $l=0$ and $1$ modes ($r_{010}$) were shown to be particularly efficient to probe these transition regions. Interestingly, in the Kepler Legacy F-type stars, the oscillatory signatures left in the $r_{010}$ ratios by the sharp sound-speed variation have unexpected large amplitudes that still need to be explained. We show that the signature of the bottom of the convective envelope is amplified in the ratios $r_{010}$ by the frequency dependence of the amplitude compared to the signal seen in the frequencies themselves or the second differences. We find that among the different options of physical input investigated here, large amplitude signatures can only be obtained when convective penetration of the surface convective zone into the underlying radiative region is taken into account. In this case and even for amplitudes as large as those observed in F-type stars, the oscillating signature in the ratios can only be detected when the convective envelope is deep enough. This deep extension of the convective envelope causes doubt that the origin of the large amplitudes is due to penetrative convection as it is modelled here or implies that current stellar modelling (without penetrative convection) leads to an underestimation of the size of convective envelopes. In any case, studying the glitch signatures of a large number of oscillating F-type stars opens the possibility to constrain the physics of the stellar interior in these regions., Comment: 19 pages, 12 figures, accepted for publication in A&A

Published
2023
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6. The Gaia-ESO Public Spectroscopic Survey: Motivation, implementation, GIRAFFE data processing, analysis, and final data products

Author

Gilmore, G., Randich, S., Worley, C. C., Hourihane, A., Gonneau, A., Sacco, G. G., Lewis, J. R., Magrini, L., Francois, P., Jeffries, R. D., Koposov, S. E., Bragaglia, A., Alfaro, E. J., Prieto, C. Allende, Blomme, R., Korn, A. J., Lanzafame, A. C., Pancino, E., Recio-Blanco, A., Smiljanic, R., Van Eck, S., Zwitter, T., Bensby, T., Flaccomio, E., Irwin, M. J., Franciosini, E., Morbidelli, L., Damiani, F., Bonito, R., Friel, E. D., Vink, J. S., Prisinzano, L., Abbas, U., Hatzidimitriou, D., Held, E. V., Jordi, C., Paunzen, E., Spagna, A., Jackson, R. J., Apellaniz, J. Maiz, Asplund, M., Bonifacio, P., Feltzing, S., Binney, J., Drew, J., Ferguson, A. M. N., Micela, G., Negueruela, I., Prusti, T., Rix, H. -W., Vallenari, A., Bergemann, M., Casey, A. R., de Laverny, P., Frasca, A., Hill, V., Lind, K., Sbordone, L., Sousa, S. G., Adibekyan, V., Caffau, E., Daflon, S., Feuillet, D. K., Gebran, M., Hernandez, J. I. Gonzalez, Guiglion, G., Herrero, A., Lobel, A., Merle, T., Mikolaitis, S., Montes, D., Morel, T., Ruchti, G., Soubiran, C., Tabernero, H. M., Tautvaisiene, G., Traven, G., Valentini, M., Van der Swaelmen, M., Villanova, S., Vazquez, C. Viscasillas, Bayo, A., Biazzo, K., Carraro, G., Edvardsson, B., Heiter, U., Jofre, P., Marconi, G., Martayan, C., Masseron, T., Monaco, L., Walton, N. A., Zaggia, S., Borsen-Koch, V. Aguirre, Alves, J., Balaguer-Nunez, L., Barklem, P. S., Barrado, D., Bellazzini, M., Berlanas, S. R., Binks, A. S., Bressan, A., Capuzzo-Dolcetta, R., Casagrande, L., Casamiquela, L., Collins, R. S., D'Orazi, V., Dantas, M. L. L., Debattista, V. P., Delgado-Mena, E., Di Marcantonio, P., Drazdauskas, A., Evans, N. W., Famaey, B., Franchini, M., Fremat, Y., Fu, X., Geisler, D., Gerhard, O., Solares, E. A. Gonzalez, Grebel, E. K., Albarran, M. L. Gutierrez, Jimenez-Esteban, F., Jonsson, H., Khachaturyants, T., Kordopatis, G., Kos, J., Lagarde, N., Ludwig, H. -G., Mahy, L., Mapelli, M., Marfil, E., Martell, S. L., Messina, S., Miglio, A., Minchev, I., Moitinho, A., Montalban, J., Monteiro, M. J. P. F. G., Morossi, C., Mowlavi, N., Mucciarelli, A., Murphy, D. N. A., Nardetto, N., Ortolani, S., Paletou, F., Palous, J., Pickering, J. C., Quirrenbach, A., Fiorentin, P. Re, Read, J. I., Romano, D., Ryde, N., Sanna, N., Santos, W., Seabroke, G. M., Spina, L., Steinmetz, M., Stonkute, E., Sutorius, E., Thevenin, F., Tosi, M., Tsantaki, M., Wright, N., Wyse, R. F. G., Zoccali, M., Zorec, J., and Zucker, D. B.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Gaia-ESO Public Spectroscopic Survey is an ambitious project designed to obtain astrophysical parameters and elemental abundances for 100,000 stars, including large representative samples of the stellar populations in the Galaxy, and a well-defined sample of 60 (plus 20 archive) open clusters. We provide internally consistent results calibrated on benchmark stars and star clusters, extending across a very wide range of abundances and ages. This provides a legacy data set of intrinsic value, and equally a large wide-ranging dataset that is of value for homogenisation of other and future stellar surveys and Gaia's astrophysical parameters. This article provides an overview of the survey methodology, the scientific aims, and the implementation, including a description of the data processing for the GIRAFFE spectra. A companion paper (arXiv:2206.02901) introduces the survey results. Gaia-ESO aspires to quantify both random and systematic contributions to measurement uncertainties. Thus all available spectroscopic analysis techniques are utilised, each spectrum being analysed by up to several different analysis pipelines, with considerable effort being made to homogenise and calibrate the resulting parameters. We describe here the sequence of activities up to delivery of processed data products to the ESO Science Archive Facility for open use. The Gaia-ESO Survey obtained 202,000 spectra of 115,000 stars using 340 allocated VLT nights between December 2011 and January 2018 from GIRAFFE and UVES. The full consistently reduced final data set of spectra was released through the ESO Science Archive Facility in late 2020, with the full astrophysical parameters sets following in 2022., Comment: 38 pages. A&A in press

Published
2022
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7. The Gaia-ESO Public Spectroscopic Survey: Implementation, data products, open cluster survey, science, and legacy

Author

Randich, S., Gilmore, G., Magrini, L., Sacco, G. G., Jackson, R. J., Jeffries, R. D., Worley, C. C., Hourihane, A., Gonneau, A., Vàzquez, C. Viscasillas, Franciosini, E., Lewis, J. R., Alfaro, E. J., Prieto, C. Allende, Blomme, T. Bensby R., Bragaglia, A., Flaccomio, E., François, P., Irwin, M. J., Koposov, S. E., Korn, A. J., Lanzafame, A. C., Pancino, E., Recio-Blanco, A., Smiljanic, R., Van Eck, S., Zwitter, T., Asplund, M., Bonifacio, P., Feltzing, S., Binney, J., Drew, J., Ferguson, A. M. N., Micela, G., Negueruela, I., Prusti, T., Rix, H. -W., Vallenari, A., Bayo, A., Bergemann, M., Biazzo, K., Carraro, G., Casey, A. R., Damiani, F., Frasca, A., Heiter, U., Hill, V., Jofré, P., de Laverny, P., Lind, K., Marconi, G., Martayan, C., Masseron, T., Monaco, L., Morbidelli, L., Prisinzano, L., Sbordone, L., Sousa, S. G., Zaggia, S., Adibekyan, V., Bonito, R., Caffau, E., Daflon, S., Feuillet, D. K., Gebran, M., Hernández, J. I. González, Guiglion, G., Herrero, A., Lobel, A., Apellániz, J. Maíz, Merle, T., Mikolaitis, S., Montes, D., Morel, T., Soubiran, C., Spina, L., Tabernero, H. M., Tautvaišienė, G., Traven, G., Valentini, M., Van der Swaelmen, M., Villanova, S., Wright, N. J., Abbas, U., Børsen-Koch, V. Aguirre, Alves, J., Balaguer-Núnez, L., Barklem, P. S., Barrado, D., Berlanas, S. R., Binks, A. S., Bressan, A., Capuzzo--Dolcetta, R., Casagrande, L., Casamiquela, L., Collins, R. S., D'Orazi, V., Dantas, M. L. L., Debattista, V. P., Delgado-Mena, E., Di Marcantonio, P., Drazdauskas, A., Evans, N. W., Famaey, B., Franchini, M., Frémat, Y., Friel, E. D., Fu, X., Geisler, D., Gerhard, O., Solares, E. A. González, Grebel, E. K., Albarrán, M. L. Gutiérrez, Hatzidimitriou, D., Held, E. V., Jiménez-Esteban, F., Jönsson, H., Jordi, C., Khachaturyants, T., Kordopatis, G., Kos, J., Lagarde, N., Mahy, L., Mapelli, M., Marfil, E., Martell, S. L., Messina, S., Miglio, A., Minchev, I., Moitinho, A., Montalban, J., Monteiro, M. J. P. F. G., Morossi, C., Mowlavi, N., Mucciarelli, A., Murphy, D. N. A., Nardetto, N., Ortolani, S., Paletou, F., Palouus, J., Paunzen, E., Pickering, J. C., Quirrenbach, A., Fiorentin, P. Re, Read, J. I., Romano, D., Ryde, N., Sanna, N., Santos, W., Seabroke, G. M., Spagna, A., Steinmetz, M., Stonkuté, E., Sutorius, E., Thévenin, F., Tosi, M., Tsantaki, M., Vink, J. S., Wright, N., Wyse, R. F. G., Zoccali, M., Zorec, J., Zucker, D. B., and Walton, N. A.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

In the last 15 years different ground-based spectroscopic surveys have been started (and completed) with the general aim of delivering stellar parameters and elemental abundances for large samples of Galactic stars, complementing Gaia astrometry. Among those surveys, the Gaia-ESO Public Spectroscopic Survey (GES), the only one performed on a 8m class telescope, was designed to target 100,000 stars using FLAMES on the ESO VLT (both Giraffe and UVES spectrographs), covering all the Milky Way populations, with a special focus on open star clusters. This article provides an overview of the survey implementation (observations, data quality, analysis and its success, data products, and releases), of the open cluster survey, of the science results and potential, and of the survey legacy. A companion article (Gilmore et al.) reviews the overall survey motivation, strategy, Giraffe pipeline data reduction, organisation, and workflow. The GES has determined homogeneous good-quality radial velocities and stellar parameters for a large fraction of its more than 110,000 unique target stars. Elemental abundances were derived for up to 31 elements for targets observed with UVES. Lithium abundances are delivered for about 1/3 of the sample. The analysis and homogenisation strategies have proven to be successful; several science topics have been addressed by the Gaia-ESO consortium and the community, with many highlight results achieved. The final catalogue has been released through the ESO archive at the end of May 2022, including the complete set of advanced data products. In addition to these results, the Gaia-ESO Survey will leave a very important legacy, for several aspects and for many years to come., Comment: Accepted for publication in Astronomy and Astrophysics. 30 pages, 30 figures, 4 tables

Published
2022
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8. On the stellar core physics of the 16 Cyg binary system: constraining the central hydrogen abundance using asteroseismology

Author

Nsamba, Benard, Cunha, Margarida S., Rocha, Catarina I. S. A., Pereira, Cristiano J. G. N., Monteiro, Mário J. P. F. G., and Campante, Tiago L.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The unprecedented quality of the asteroseismic data of solar-type stars made available by space missions such as NASA's Kepler telescope are making it possible to explore stellar interior structures. This offers possibilities of constraining stellar core properties (such as core sizes, abundances, and physics) paving the way for improving the precision of the inferred stellar ages. We employ 16 Cyg A and B as our benchmark stars for an asteroseismic study in which we present a novel approach aimed at selecting from a sample of acceptable stellar models returned from Forward Modelling techniques, down to the ones that better represent the core of each star. This is accomplished by comparing specific properties of the observed frequency ratios for each star to the ones derived from the acceptable stellar models. We demonstrate that in this way we are able to constrain further the hydrogen mass fraction in the core, establishing the stars' precise evolutionary states and ages. The ranges of the derived core hydrogen mass fractions are [0.01 - 0.06] and [0.12 - 0.19] for 16 Cyg A and B, respectively, and, considering that the stars are coeval, the age and metal mass fraction parameters span the region [6.4 - 7.4] Gyr and [0.023 - 0.026], respectively. In addition, our findings show that using a single helium-to-heavy element enrichment ratio, ($\Delta Y/\Delta Z$), when forward modelling the 16 Cyg binary system, may result in a sample of acceptable models that do not simultaneously fit the observed frequency ratios, further highlighting that such an approach to the definition of the helium content of the star may not be adequate in studies of individual stars., Comment: 13 pages, 8 figures, and 5 tables. Accepted for publication in MNRAS

Published
2022
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10. A mimetic peptide of ACE2 protects against SARS-CoV-2 infection and decreases pulmonary inflammation related to COVID-19

Author

Oliveira, Ernna H., Monteleone-Cassiano, Ana C., Tavares, Lucas, Santos, Jadson C., Lima, Thais M., Gomes, Giovanni F., Tanaka, Pedro P., Monteiro, Cintia J., Munuera, Matheus, Batah, Sabrina S., Fabro, Alexandre T., Faça, Vitor M., Masson, Ana P., Donadi, Eduardo A., Dametto, Mariangela, Bonacin, Rodrigo, Martins, Ronaldo B., Jr., Neto, Eurico Arruda, daSilva, Luis Lamberti P., Cunha, Thiago M., and Passos, Geraldo A.

Published
2024
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12. Fish School Search Algorithm for Constrained Optimization

Author

Alcântara, J. P. M., Monteiro-Filho, J. B., Albuquerque, I. M. C., Villar-Dias, J. L., Lacerda, M. G. P., Lima-Neto, F. B., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Abraham, Ajith, editor, Hong, Tzung-Pei, editor, Kotecha, Ketan, editor, Ma, Kun, editor, Manghirmalani Mishra, Pooja, editor, and Gandhi, Niketa, editor

Published
2023
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13. Individualizing the Autism Assessment Process: A Framework for School Psychologists

Author

Monteiro, Marilyn J.

Abstract

School psychologists familiar with the autism evaluation process have an awareness of the complexity of this school-based process. This paper provides school clinicians with an introduction to a visual framework and descriptive language to think and talk about the complex students they evaluate in positive, nuanced, and accessible terms. This framework shifts the way in which school psychologists describe students during the autism assessment process away from the reductive language of deficits to the expansive language of describing individualized patterns of strengths and differences. The shift away from labeling behavioral deficits to describing patterns of behavioral differences leads to a positive narrative and creative ways to develop supports and interventions for students across age and ability levels. The use of this strength-based language supports parents, teachers, and students in their development of an individualized understanding of the diagnosis, promoting resiliency in the individual and in their support systems. Readers are provided with a student sample case to show how using this visual framework provides a way to describe individual students using a behavioral profile of strengths and differences, linking those profiles to positive behavior supports.

Published
2022
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19. Genome‐Wide Population Structure in a Marine Keystone Species, the European Flat Oyster (Ostrea edulis)

Author

Alves Monteiro, Homère J., Bekkevold, Dorte, Pacheco, George, Mortensen, Stein, Lou, Runyang Nicolas, Therkildsen, Nina O., Tanguy, Arnaud, Robert, Chloé, De Wit, Pierre, Meldrup, Dorte, Laugen, Ane T., Ermgassen, Philine S. E., Strand, Åsa, Saurel, Camille, and Hemmer‐Hansen, Jakob

Abstract

ABSTRACT Ostrea edulis, the European flat oyster, was once a widespread economically and ecologically important marine species, but has suffered dramatic declines over the past two centuries. Consequently, there has been a surge in European restoration efforts, many of which focus on restocking as a conservation measure. In this study, we used whole‐genome sequencing (WGS) data to investigate the population structure, demographic history, and patterns of local adaptation of O. edulis across its natural distribution with increased sampling densities at Scandinavian localities. Results revealed seven distinct genetic clusters, including previously undescribed complex population structure in Norway, and evidence for introgression between genetic clusters in Scandinavia. We detected large structural variants (SVs) on three pseudo‐chromosomes. These megabase long regions were characterised by strong linkage disequilibrium and clear geographical differentiation, suggestive of chromosomal inversions potentially associated with local adaptation. The results indicated that genomic traces of past translocations of non‐native O. edulis were still present in some individuals, but overall, we found limited evidence of major impacts of translocations on the scale of contemporary population structure. Our findings highlight the importance of considering population structure and signatures of selection in the design of effective conservation strategies to preserve and restore wild native European flat oyster populations, and we provide direct knowledge safeguarding sustainable mitigation actions in this important species. [ABSTRACT FROM AUTHOR]

Published
2024
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20. The single-cell transcriptome of mTECs and CD4+ thymocytes under adhesion revealed heterogeneity of mTECs and a network controlled by Aire and lncRNAs.

Author

Monteiro, Cíntia J., Duarte, Max J., Machado, Mayara Cristina V., Mascarenhas, Romário S., Bonini Palma, Patrícia V., García, Henry D. Mogollón, Nakaya, Helder I., Cunha, Thiago M., Donadi, Eduardo A., and Passos, Geraldo A.

Subjects
LINCRNA, GENE expression, CELL metabolism, CELL cycle, THYMOCYTES
Abstract

To further understand the impact of deficiency of the autoimmune regulator (Aire) gene during the adhesion of medullary thymic epithelial cells (mTECs) to thymocytes, we sequenced single-cell libraries (scRNA-seq) obtained from Aire wild-type (WT) (Airewt/wt) or Aire-deficient (Airewt/mut) mTECs cocultured with WT single-positive (SP) CD4+ thymocytes. Although the libraries differed in their mRNA and long noncoding RNA (lncRNA) profiles, indicating that mTECs were heterogeneous in terms of their transcriptome, UMAP clustering revealed that both mTEC lines expressed their specific markers, i.e., Epcam, Itgb4, Itga6, and Casp3 in resting mTECs and Ccna2, Pbk, and Birc5 in proliferative mTECs. Both cocultured SP CD4+ thymocytes remained in a homogeneous cluster expressing the Il7r and Ccr7markers. Comparisons of the two types of cocultures revealed the differential expression of mRNAs that encode transcription factors (Zfpm2, Satb1, and Lef1), cell adhesion genes (Itgb1) inmTECs, and Themis in thymocytes, which is associated with the regulation of positive and negative selection. At the single-cell sequencing resolution, we observed that Aire acts on both Aire WT and Airedeficient mTECs as an upstream controller of mRNAs, which encode transcription factors or adhesion proteins that, in turn, are posttranscriptionally controlled by lncRNAs, for example, Neat1, Malat1, Pvt1, and Dancr among others. Under Aire deficiency, mTECs dysregulate the expression of MHC-II, CD80, and CD326 (EPCAM) protein markers as well as metabolism and cell cycle-related mRNAs, which delay the cell cycle progression. Moreover, when adhered to mTECs, WT SP CD4+ or CD8+ thymocytes modulate the expression of cell activation proteins, including CD28 and CD152/CTLA4, and the expression of cellular metabolism mRNAs. These findings indicate a complex mechanism through which an imbalance in Aire expression can affect mTECs and thymocytes during adhesion. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Bone targeted nano-drug and nano-delivery.

Author

Wu, Yilun, Sun, Bing, Tang, Ying, Shen, Aining, Lin, Yanlin, Zhao, Xiaohui, Li, Jingui, Monteiro, Michael J., and Gu, Wenyi

Subjects
TARGETED drug delivery, CONTROLLED release drugs, DRUG therapy, BONE diseases, SMALL molecules, DRUG delivery systems
Abstract

There are currently no targeted delivery systems to satisfactorily treat bone-related disorders. Many clinical drugs consisting of small organic molecules have a short circulation half-life and do not effectively reach the diseased tissue site. This coupled with repeatedly high dose usage that leads to severe side effects. With the advance in nanotechnology, drugs contained within a nano-delivery device or drugs aggregated into nanoparticles (nano-drugs) have shown promises in targeted drug delivery. The ability to design nanoparticles to target bone has attracted many researchers to develop new systems for treating bone related diseases and even repurposing current drug therapies. In this review, we shall summarise the latest progress in this area and present a perspective for future development in the field. We will focus on calcium-based nanoparticle systems that modulate calcium metabolism and consequently, the bone microenvironment to inhibit disease progression (including cancer). We shall also review the bone affinity drug family, bisphosphonates, as both a nano-drug and nano-delivery system for bone targeted therapy. The ability to target and release the drug in a controlled manner at the disease site represents a promising safe therapy to treat bone diseases in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Expanding the frontiers of cool-dwarf asteroseismology with ESPRESSO. Detection of solar-like oscillations in the K5 dwarf ϵ Indi

Author

Campante, T. L., primary, Kjeldsen, H., additional, Li, Y., additional, Lund, M. N., additional, Silva, A. M., additional, Corsaro, E., additional, Gomes da Silva, J., additional, Martins, J. H. C., additional, Adibekyan, V., additional, Azevedo Silva, T., additional, Bedding, T. R., additional, Bossini, D., additional, Buzasi, D. L., additional, Chaplin, W. J., additional, Costa, R. R., additional, Cunha, M. S., additional, Cristo, E., additional, Faria, J. P., additional, García, R. A., additional, Huber, D., additional, Lundkvist, M. S., additional, Metcalfe, T. S., additional, Monteiro, M. J. P. F. G., additional, Neitzel, A. W., additional, Nielsen, M. B., additional, Poretti, E., additional, Santos, N. C., additional, and Sousa, S. G., additional

Published
2024
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27. Brief report: caregivers' well-being in families with neurodevelopmental disorders members during COVID-19: implications for family therapy.

Author

Sousa, Daniela, Ferreira, Ana, Sequeira, Joana, Monteiro, Marilyn J., Simões, Marco, and Castelo-Branco, Miguel

Subjects
FAMILY relations, BURDEN of care, COVID-19 pandemic, FAMILY psychotherapy, CAREGIVERS
Abstract

Neurodevelopmental disorders affect the lifespan of diagnosed individuals and their families. COVID-19 challenged these families with daily routine unpredictability requiring rapid adaptations. Moreover, associations and schools were closed, leaving these families without regular social support. Here, we investigate which individual and family factors can predict the caregiver's depressive state and overall burden. An online study took place between 2021 and 2022. A total of 32 caregivers (30 women; 48 ± 8.22 years old; range 26 to 63 years old) reported having a family member with a neurodevelopmental disorder, the majority diagnosed with autism spectrum disorder. Caregivers responded to a protocol to assess the burden, resilience, depressive, anxious, and stress symptomatology, as well as the behavior of the diagnosed individual. Hierarchical multiple regressions were performed to identify protective and risk factors for the caregivers' well-being. Caregivers' depressive statewas explained by 29.3% of the variance of the family cohesion factor, indicating that high levels of balanced family cohesion represent a crucial protective factor for reducing the caregiver's depressive state. Additionally, overall caregiver burden was explained by 17.8% of the variance due to self-perception and 26.4% due to family cohesion, with the caregiver's self-perception playing an important protective role in the overall perception of burden. The proportion of male and female respondents seems to corroborate the significant role of women in caregiving. These results emphasize the importance of considering both individual and family factors of caregivers during interventions, which have implications for family therapy with families of members diagnosed with neurodevelopmental disorders, specifically with autism. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Polymeric Nanoparticles as Oral and Intranasal Peptide Vaccine Delivery Systems: The Role of Shape and Conjugation

Author

Koirala, Prashamsa, primary, Shalash, Ahmed O., additional, Chen, Sung-Po R., additional, Faruck, Mohammad O., additional, Wang, Jingwen, additional, Hussein, Waleed M., additional, Khalil, Zeinab G., additional, Capon, Robert J., additional, Monteiro, Michael J., additional, Toth, Istvan, additional, and Skwarczynski, Mariusz, additional

Published
2024
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39. The ribonucleoprotein-mediated CRISPR‒Cas9 system induces recurrent Aire gene mutations in contrast to the nickase expression vector in murine in vitro or in vivo models

Author

Tanaka, Pedro P, primary, Monteiro, Cintia J, additional, Duarte, Max J, additional, Oliveira, Ernna H, additional, Monteleone-Cassiano, Ana C, additional, Mascarenhas, Romario S, additional, Machado, Mayara C, additional, Matos, Adriana A, additional, Brito, Leticia A, additional, Ozorio, Aline O, additional, Cunha, Thiago M, additional, Donadi, Eduardo Antônio, additional, and Passos, Geraldo A, additional

Published
2023
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40. Genetic parentage reconstruction as a practical tool applied to aquaculture and restoration programs for the European flat oyster, Ostrea edulis

Author

Alves Monteiro Homère J., Saurel Camille, Jacobsen Maj-Britt, Hemmer-Hansen Jakob, and Bekkevold Dorte

Subjects
european native oyster (ostrea edulis), bivalves, parentage assignment, breeding program, hatchery, conservation, spat supply, Aquaculture. Fisheries. Angling, SH1-691
Abstract

Preserving and maximizing genetic diversity in conservation programs, including for restocking, are of high importance. The threatened European flat oyster (Ostrea edulis) is currently the subject of several applied conservation and restocking programs, but concerns have been raised over potential negative side effects of these programs, for example due to our limited knowledge about the genetic effects in natural populations of releasing offspring of hatchery origin. Here, we developed an effective, easily applicable and highly reliable method to assess the genetic diversity and parental contributions in flat oyster hatchery production based on analyses of 17 microsatellite loci. We analysed four broodstocks and their hatchery-reared spat (total n = 354) and compared diversity to that in wild samples of adults and spat from the broodstock source in the Limfjorden (total n = 138). Based on four hatchery tank experiments with fully resolved parentage assignments, we found that five swarming events (larval releases) were characterized by a single maternal and multiple paternal contributions, and that the number of contributing parents varied greatly both among individual tanks, and between swarming events within tank. On average, the effective number of breeders was only one third of the actual broodstock size. Although the broodstock exhibited high genetic variation, the high reproductive skew resulted in produced offspring representing only a relatively small subset of this variation. The work demonstrates potential impact of hatchery reared offspring on decreasing genetic diversity in wild populations, but also that genetic monitoring can be integrated in conservation programs to minimize negative effects on restoration and supplementary restocking programs that utilize hatchery reared spats to support natural populations.

Published
2022
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42. Firefly: The Case for a Holistic Understanding of the Global Structure and Dynamics of the Sun and the Heliosphere

Author

Raouafi, Nour E., primary, Hoeksema, J. Todd, additional, Newmark, Jeffrey S., additional, Gibson, Sarah, additional, Berger, Thomas E., additional, Upton, Lisa A., additional, Vourlidas, Angelos, additional, Hassler, Donald M., additional, Kinnison, James, additional, Ho, George C., additional, Mason, Glenn M., additional, Vievering, Juliana T., additional, Viall, Nicholeen M., additional, Szabo, Adam, additional, Casti, Marta, additional, Case, Anthony W., additional, Lepri, Susan T., additional, Velli, Marco, additional, Georgoulis, Manolis K., additional, Bourouaine, Sofiane, additional, Jagarlamudi, Vamsee K., additional, Laming, John M., additional, Mason, James P., additional, Harra, Louise, additional, Madjarska, Maria, additional, Chitta, Lakshmi Pradeep, additional, Duran, J. Sebastian Castellanos, additional, Korpi-Lagg, Andreas, additional, Badman, Samuel, additional, Chifu, Iulia, additional, Lario, David, additional, Wing, Simon, additional, Bale, Stuart, additional, Paouris, Evangelos, additional, Narayanamurthy, Smitha, additional, Sinjan, Jonas, additional, Bernasconi, Pietro, additional, Krivova, Natalie, additional, Gizon, Laurent, additional, Leamon, Robert J., additional, Gosain, Sanjay, additional, Kazachenko, Maria, additional, Petrie, Gordon, additional, Pillet, Valentin Martinez, additional, Jain, Kiran, additional, Luhmann, Janet, additional, Bertello, Luca, additional, Toriumi, Shin, additional, Jiang, Chen, additional, Vasko, Ivan, additional, Harvey, John W., additional, Schad, Thomas A., additional, Jebaraj, Immanuel C., additional, Scherrer, Philip, additional, Hofmeister, Stefan, additional, Tiwari, Sanjiv, additional, Wang, Haimin, additional, Roth, Markus, additional, Panesar, Navdeep, additional, Sekii, Takashi, additional, Magyar, Norbert, additional, Guglielmino, Salvo L., additional, Parenti, Susanna, additional, Tremblay, Benoit, additional, Tziotziou, Kostas, additional, Toma, Giuliana de, additional, Chen, Bin, additional, Katsukawa, Yukio, additional, Pontieu, Bart De, additional, Cheng, Xin, additional, Cheung, Mark, additional, Kosovichev, Alexander, additional, Jiang, Jie, additional, Schunker, Hannah, additional, Kawabata, Yusuke, additional, Oba, Takayoshi, additional, Cameron, Robert, additional, Mathew, Shibu K., additional, Rodriguez, Jaime de la Cruz, additional, Kusano, Kanya, additional, Temmer, Manuela, additional, Andretta, Vincenzo, additional, Sven, Wedemeyer, additional, Samara, Evangelia, additional, Heinemann, Stephan G., additional, Warmuth, Alexander, additional, Jafarzadeh, Shahin, additional, Mackay, Duncan H., additional, Fludra, Andrzej, additional, Rubio, Luis Bellot, additional, Suárez, David Orozco, additional, Chen, Thomas Y., additional, Kontogiannis, Ioannis, additional, Yardley, Stephanie, additional, Veronig, Astrid, additional, Joshi, Jayant, additional, Spadaro, Daniele, additional, Kubo, Masahito, additional, Bose, Souvik, additional, González, Nazaret Bello, additional, Solanki, Sami, additional, Denker, Carsten, additional, Verma, Meetu, additional, Vocks, Christian, additional, Borrero, Juan Manuel, additional, Mathews, Nathaniel H., additional, Cury, Shannon, additional, Sasso, Clementina, additional, Stenborg, Guillermo, additional, Tibebu, Getachew, additional, Battams, Karl, additional, Wijsen, Nicolas, additional, Bruno, Alessandro, additional, Peter, Hardi, additional, I., Mason Emily, additional, M., Caplan Ronald, additional, Martinez-Sykora, Juan, additional, Seaton, Daniel, additional, Airapetian, Vladimir, additional, Jian, Lan, additional, Thompson, William T., additional, Ofman, Leon, additional, Wallace, Samantha, additional, Kucera, Therese, additional, Desai, Ravindra, additional, Richardson, Ian, additional, Burkepile, Joan, additional, Cranmer, Steven, additional, Strauss, R. Du Toit, additional, Murabito, Mariarita, additional, Alfred, De Wijn, additional, Xie, Hong, additional, Rempel, Matthias, additional, Webber, Shea Hess, additional, Reeves, Katharine K., additional, Hurlburt, Neal, additional, Berrilli, Francesco, additional, DeLuca, Edward, additional, Egeland, Ricky, additional, Ko, Yuan-Kuen, additional, Kee, Nathaniel Dylan, additional, Mahajan, Sushant S., additional, Craig, DeForest, additional, Wood, Brian E., additional, Chris, Chaston, additional, Nigro, Giuseppina, additional, Shaik, Shaheda Begum, additional, Gosic, Milan, additional, Shimizu, Toshifumi, additional, Zuccarello, Francesca, additional, Nitta, Nariaki, additional, Chatzistergos, Theodosios, additional, Fan, Yuhong, additional, Zhang, Jie, additional, Fehlmann, Andre, additional, Palmerio, Erika, additional, Ishikawa, Ryohtaroh T., additional, Danilovic, Sanja, additional, Skan, Moa, additional, Froment, Clara, additional, Baso, Carlos José Díaz, additional, Liang, Zhi-Chao, additional, Wit, Thierry Dudok de, additional, Barczynski, Krzysztof, additional, Johnston, Craig, additional, Pariat, Etienne, additional, Hadid, Lina, additional, Aulanier, Guillaume, additional, Brun, Allan Sacha, additional, Athanasios, Kouloumvakos, additional, Cauzzi, Gianna, additional, Dredger, Pauline, additional, French, Ryan, additional, Christian, Damian, additional, Linton, Mark, additional, Ireland, Jack, additional, Tarr, Lucas, additional, Strugarek, Antoine, additional, Uritsky, Vadim, additional, DeRosa, Marc, additional, Kretzschmar, Matthieu, additional, García, Rafael A., additional, Monteiro, Mario J. P. F. G., additional, Mathur, Savita, additional, Breton, Sylvain N., additional, Pinto, Rui F., additional, Oliveros, Juan Carlos Martinez, additional, Loper, Robert, additional, Auchère, Frédéric, additional, Wang, Tongjiang, additional, Reginald, Nelson, additional, Cunha, Margarida S., additional, Teriaca, Luca, additional, Chintzoglou, Georgios, additional, Lynch, Benjamin J., additional, Linker, Jon, additional, Beck, Paul, additional, Shannon, Jackson, additional, Clare, Benjamin, additional, Krupiarz, Christopher, additional, Whiting, Ian D., additional, Byerly, Adam, additional, Bushman, Stewart, additional, Carrelli, David, additional, Kijewski, Seth, additional, Englander, Jacob, additional, Mizes, Adam, additional, Porter, Jamie, additional, O’Neill, Michael, additional, Chattopadhyay, Debarati, additional, Albers, Joshua, additional, Rast, Mark, additional, Ermolli, Ilaria, additional, Tzeng, Nigel, additional, Hudson, James F., additional, Giunta, Alessandra, additional, Buchlin, Éric, additional, Bommier, Véronique, additional, Duncan, Nicole, additional, Janvier, Miho, additional, Strecker, Hanna, additional, Siu, Azaymi, additional, Perri, Barbara, additional, Maksimovic, Milan, additional, Vilmer, Nicole, additional, Toledo-Redondo, Sergio, additional, Kuckein, Christoph, additional, Alberti, Tommaso, additional, Antolin, Patrick, additional, Cuadrado, Regina Aznar, additional, Berghmans, David, additional, Brigitte, Schmieder, additional, Bucik, Radoslav, additional, Calchetti, Daniele, additional, Caspi, Amir, additional, Cohen, Christina, additional, Corbard, Thierry, additional, Cremades, Hebe, additional, Cummings, Alan, additional, Dhakal, Suman, additional, Dolla, Laurent, additional, Dominique, Marie, additional, Emslie, Gordon, additional, Ferrente, Fabiana, additional, Finley, Adam J., additional, Fletcher, Lyndsay, additional, Fraschetti, Federico, additional, Gafeira, Ricardo, additional, Gissot, Samuel, additional, Hegde, Dinesha, additional, Hu, Qiang, additional, Innocenti, Maria Elena, additional, Jin, Meng, additional, Klein, Kristopher, additional, Kumar, Pankaj, additional, Lacatus, Daniela, additional, Liewer, Paulett, additional, Magdalenic, Jasmina, additional, Mandal, Sudip, additional, Mandrini, Cristina H., additional, Mierla, Marilena, additional, Miralles, Mari Paz, additional, Moore, Ron, additional, Neville, Jonathan, additional, Niembro, Tatiana, additional, Nikou, Eleni, additional, Nindos, Alexander, additional, Papaioannou, Athanasios, additional, Rajaguru, S. Paul, additional, Reville, Victor, additional, Rochus, Pierre, additional, Rodriguez, Luciano, additional, Romoli, Marco, additional, Shestov, Sergei, additional, Shi, Chen, additional, Sorriso-Valvo, Luca, additional, St. Cyr, O. C., additional, Sterling, Alphohse, additional, Stevens, Michael L., additional, Susino, Roberto, additional, Swisdak, Marc, additional, Thompson, Barbara J., additional, Valliappan, Senthamizh Pavai, additional, Verbeeck, Francis, additional, Bothmer, Volker, additional, Xudong, Sun, additional, Zhukov, Andrei, additional, Katsiyannis, Thanassis, additional, Owen, Christopher, additional, Karna, Nishu, additional, Janssens, Jan, additional, Khomenko, Elena, additional, Gary, Dale, additional, Bandyopadhyay, Riddhi, additional, Chhiber, Rohit, additional, Tenerani, Anna, additional, Rouillard, Alexis, additional, Patsourakos, Spiros, additional, Anastasiadis, Anastasios, additional, Bocchialini, Karine, additional, Moraitis, Kostas, additional, Rivera, Yeimy, additional, Drake, James, additional, Baudin, Frédéric, additional, Chandran, Benjamin, additional, Dayeh, Maher, additional, Reardon, Kevin, additional, Cairns, Iver, additional, Bizien, Nina, additional, Wexler, David, additional, Bahauddin, Shah, additional, Rodriguez-Pacheco, Javier, additional, Yu, Sijie, additional, Lee, Jeongwoo, additional, Gontikakis, Costis, additional, Koukras, Alexandros, additional, Contel, Olivier Le, additional, Pezzi, Oreste, additional, Kintziger, Christian, additional, Boumier, Patrick, additional, Balasis, Georgios, additional, Dikpati, Mausumi, additional, Pesnell, W. Dean, additional, Chai, Yi, additional, Nandy, Dibyendu, additional, Charles, Arge, additional, Corti, Claudio, additional, Zhao, Lulu, additional, Matthaeus, William H., additional, Gilly, Chris R., additional, Erlandson, Robert E., additional, Derouich, Moncef, additional, Zhao, Lingling, additional, Poedts, Stefaan, additional, Vieira, Luis, additional, Adhikari, Laxman, additional, Buitrago-Casas, Juan Camilo, additional, Huang, Jia, additional, Moestl, Christian, additional, Liu, Mingzhe, additional, Oloketuyi, Jacob, additional, Zhuang, Bin, additional, Rodríguez-García, Laura, additional, Perez, Jean Carlos, additional, Xu, Zigong, additional, Kooi, Jason, additional, Woodham, Lloyd D., additional, Tripathi, Durgesh, additional, Young, Peter, additional, López-Portela, Cynthia, additional, Cuesta, Manuel Enrique, additional, and Wilson, Lynn, additional

Published
2023
Full Text
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43. Effect of Loading Frequency on the Fretting-Corrosion Degradation of the Stem-Head and Stem-Cement Interfaces in Hip Implants.

Author

dos Santos, Vinícius O., Cubillos, Patricia O., dos Santos, Claudio T., Monteiro, Maurício J., Caminha, Ieda M. V., Moré, Ari D. O., and Roesler, Carlos R. M.

Abstract

Degradation by fretting-corrosion of the stem-head interface is considered the main source of the release of metal ions and debris, leading to adverse tissue reactions at the cemented total hip arthroplasty. The aim of this study was to investigate the effect of loading frequency on the fretting-corrosion degradation at the stem-head and stem-cement interfaces through electrochemical measurements during the benchtop testing. Different loading frequency conditions were investigated with the same number of cycles (1,000 cycles) to calculate the fretting current and Faraday mass loss. For both interfaces, there was a biphasic waveform response of the fretting current to the load applied, at 1 Hz, almost with phase opposition. An increase in the loading frequency (1 to 30 Hz) generated a higher fretting current for the stem-head (2.97 ± 2.04 µA to 7.66 ± 2.46 µA) and stem-cement (7.62 ± 2.26 µA to 25.48 ± 5.35 µA) interfaces. However, an increase in the loading frequency (1 to 30 Hz) reduced the Faraday mass loss of the stem-head (0.79 ± 0.54 µg to 0.07 ± 0.02 µg) and stem-cement (2.02 ± 0.62 µg to 0.32 ± 0.12 µg) interfaces because of a reduction in the overall testing time. Thus, there is a compromise relation between the fretting current and the Faraday mass loss, which must be considered when setting the loading frequencies in the fretting-corrosion benchtop testing of hip implants. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Green innovation ecosystem and water performance in the food service industry: The effects of environmental management controls and digitalization.

Author

Rosa, Fabricia S., Compagnucci, Lorenzo, Lunkes, Rogerio J., and Monteiro, Januário J.

Subjects
POLLUTION control industry, FOOD service, ENVIRONMENTAL management, MANAGEMENT controls, FOOD industry, ECOSYSTEMS, SUSTAINABILITY
Abstract

Based on the theory of innovation ecosystems (IEs) and the literature on environmental management controls (EMCs), this study examines the effects of green innovation ecosystems (GIEs), EMCs, and digitalization on the water performance of firms in the food service industry (FSI). In this context, the moderating role of technology sensing/response (TSR) is explored. Surveying 245 managers in large Brazilian restaurants, the hypotheses are tested through partial least squares structural equation modeling. The findings reveal that the GIE positively influences digitalization and the use of both diagnostic and interactive EMCs. Additionally, the results demonstrate not only that interactive EMCs improve water performance but also that a high level of TSR increases the impact of diagnostic EMCs on water performance. This study therefore advances the literature by illustrating how cooperation between FSI firms and multiagents provides competences and resources that facilitate the implementation of digital tools and EMCs to achieve sustainability outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Revisiting the Red Giant Branch Hosts KOI-3886 and ι Draconis. Detailed Asteroseismic Modeling and Consolidated Stellar Parameters

Author

Campante, Tiago L., primary, Li, Tanda, additional, Ong, J. M. Joel, additional, Corsaro, Enrico, additional, Cunha, Margarida S., additional, Bedding, Timothy R., additional, Bossini, Diego, additional, Breton, Sylvain N., additional, Buzasi, Derek L., additional, Chaplin, William J., additional, Deal, Morgan, additional, García, Rafael A., additional, Hill, Michelle L., additional, Hon, Marc, additional, Huber, Daniel, additional, Jiang, Chen, additional, Kane, Stephen R., additional, Kayhan, Cenk, additional, Kuszlewicz, James S., additional, Lillo-Box, Jorge, additional, Mathur, Savita, additional, F. G. Monteiro, Mário J. P., additional, Pereira, Filipe, additional, Santos, Nuno C., additional, Serenelli, Aldo, additional, and Stello, Dennis, additional

Published
2023
Full Text
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