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39 results on '"Monaco, Claudia"'

1. Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis

Author

Döring, Yvonne, van der Vorst, Emiel P. C., Yan, Yi, Neideck, Carlos, Blanchet, Xavier, Jansen, Yvonne, Kemmerich, Manuela, Bayasgalan, Soyolmaa, Peters, Linsey J. F., Hristov, Michael, Bidzhekov, Kiril, Yin, Changjun, Zhang, Xi, Leberzammer, Julian, Li, Ya, Park, Inhye, Kral, Maria, Nitz, Katrin, Parma, Laura, Gencer, Selin, Habenicht, Andreas J. R., Faussner, Alexander, Teupser, Daniel, Monaco, Claudia, Holdt, Lesca, Megens, Remco T. A., Atzler, Dorothee, Santovito, Donato, von Hundelshausen, Philipp, and Weber, Christian

Published
2024
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2. Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications

Author

Dib, Lea, Koneva, Lada A., Edsfeldt, Andreas, Zurke, Yasemin-Xiomara, Sun, Jiangming, Nitulescu, Mihaela, Attar, Moustafa, Lutgens, Esther, Schmidt, Steffen, Lindholm, Marie W., Choudhury, Robin P., Cassimjee, Ismail, Lee, Regent, Handa, Ashok, Goncalves, Isabel, Sansom, Stephen N., and Monaco, Claudia

Published
2023
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3. Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs

Author

Weeratunga, Praveen, Denney, Laura, Bull, Joshua A., Repapi, Emmanouela, Sergeant, Martin, Etherington, Rachel, Vuppussetty, Chaitanya, Turner, Gareth D. H., Clelland, Colin, Woo, Jeongmin, Cross, Amy, Issa, Fadi, de Andrea, Carlos Eduardo, Melero Bermejo, Ignacio, Sims, David, McGowan, Simon, Zurke, Yasemin-Xiomara, Ahern, David J., Gamez, Eddie C., Whalley, Justin, Richards, Duncan, Klenerman, Paul, Monaco, Claudia, Udalova, Irina A., Dong, Tao, Antanaviciute, Agne, Ogg, Graham, Knight, Julian C., Byrne, Helen M., Taylor, Stephen, and Ho, Ling-Pei

Published
2023
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5. Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation

Author

Mokry, Michal, Boltjes, Arjan, Slenders, Lotte, Bel-Bordes, Gemma, Cui, Kai, Brouwer, Eli, Mekke, Joost M., Depuydt, Marie A. C., Timmerman, Nathalie, Waissi, Farahnaz, Verwer, Maarten C., Turner, Adam W., Khan, Mohammad Daud, Hodonsky, Chani J., Diez Benavente, Ernest, Hartman, Robin J. G., van den Dungen, Noortje A. M., Lansu, Nico, Nagyova, Emilia, Prange, Koen H. M., Kovacic, Jason C., Björkegren, Johan L. M., Pavlos, Eleftherios, Andreakos, Evangelos, Schunkert, Heribert, Owens, Gary K., Monaco, Claudia, Finn, Aloke V., Virmani, Renu, Leeper, Nicholas J., de Winther, Menno P. J., Kuiper, Johan, de Borst, Gert J., Stroes, Erik S. G., Civelek, Mete, de Kleijn, Dominique P. V., den Ruijter, Hester M., Asselbergs, Folkert W., van der Laan, Sander W., Miller, Clint L., and Pasterkamp, Gerard

Published
2022
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8. Author Correction: Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications

Author

Dib, Lea, Koneva, Lada A., Edsfeldt, Andreas, Zurke, Yasemin-Xiomara, Sun, Jiangming, Nitulescu, Mihaela, Attar, Moustafa, Lutgens, Esther, Schmidt, Steffen, Lindholm, Marie W., Choudhury, Robin P., Cassimjee, Ismail, Lee, Regent, Handa, Ashok, Goncalves, Isabel, Sansom, Stephen N., and Monaco, Claudia

Published
2023
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9. Publisher Correction: Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications

Author

Dib, Lea, Koneva, Lada A., Edsfeldt, Andreas, Zurke, Yasemin-Xiomara, Sun, Jiangming, Nitulescu, Mihaela, Attar, Moustafa, Lutgens, Esther, Schmidt, Steffen, Lindholm, Marie W., Choudhury, Robin P., Cassimjee, Ismail, Lee, Regent, Handa, Ashok, Goncalves, Isabel, Sansom, Stephen N., and Monaco, Claudia

Published
2023
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10. Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Author

Ahern, David J, Ai, Zhichao, Ainsworth, Mark, Allan, Chris, Allcock, Alice, Angus, Brian, Ansari, M Azim, Arancibia-Cárcamo, Carolina, Aschenbrenner, Dominik, Attar, Moustafa, Baillie, J Kenneth, Barnes, Eleanor, Bashford-Rogers, Rachael, Bashyal, Archana, Beer, Sally, Berridge, Georgina, Beveridge, Amy, Bibi, Sagida, Bicanic, Tihana, Blackwell, Luke, Bowness, Paul, Brent, Andrew, Brown, Andrew, Broxholme, John, Buck, David, Burnham, Katie, Byrne, Helen, Camara, Susana, Ferreira, Ivan Candido, Charles, Philip, Chen, Wentao, Chen, Yi-Ling, Chong, Amanda, Clutterbuck, Elizabeth, Coles, Mark, Conlon, Christopher, Cornall, Richard, Cribbs, Adam, Curion, Fabiola, Davenport, Emma, Davidson, Neil, Davis, Simon, Dendrou, Calliope, Dequaire, Julie, Dib, Lea, Docker, James, Dold, Christina, Dong, Tao, Downes, Damien, Drakesmith, Hal, Dunachie, Susanna, Duncan, David, Eijsbouts, Chris, Esnouf, Robert, Espinosa, Alexis, Etherington, Rachel, Fairfax, Benjamin, Fairhead, Rory, Fang, Hai, Fassih, Shayan, Felle, Sally, Fernandez Mendoza, Maria, Ferreira, Ricardo, Fischer, Roman, Foord, Thomas, Forrow, Aden, Frater, John, Fries, Anastasia, Gallardo Sanchez, Veronica, Garner, Lucy, Geeves, Clementine, Georgiou, Dominique, Godfrey, Leila, Golubchik, Tanya, Gomez Vazquez, Maria, Green, Angie, Harper, Hong, Harrington, Heather, Heilig, Raphael, Hester, Svenja, Hill, Jennifer, Hinds, Charles, Hird, Clare, Ho, Ling-Pei, Hoekzema, Renee, Hollis, Benjamin, Hughes, Jim, Hutton, Paula, Jackson-Wood, Matthew, Jainarayanan, Ashwin, James-Bott, Anna, Jansen, Kathrin, Jeffery, Katie, Jones, Elizabeth, Jostins, Luke, Kerr, Georgina, Kim, David, Klenerman, Paul, Knight, Julian, Kumar, Vinod, Kumar Sharma, Piyush, Kurupati, Prathiba, Kwok, Andrew, Lee, Angela, Linder, Aline, Lockett, Teresa, Lonie, Lorne, Lopopolo, Maria, Lukoseviciute, Martyna, Luo, Jian, Marinou, Spyridoula, Marsden, Brian, Martinez, Jose, Matthews, Philippa, Mazurczyk, Michalina, McGowan, Simon, McKechnie, Stuart, Mead, Adam, Mentzer, Alexander, Mi, Yuxin, Monaco, Claudia, Montadon, Ruddy, Napolitani, Giorgio, Nassiri, Isar, Novak, Alex, O'Brien, Darragh, O'Connor, Daniel, O'Donnell, Denise, Ogg, Graham, Overend, Lauren, Park, Inhye, Pavord, Ian, Peng, Yanchun, Penkava, Frank, Pereira Pinho, Mariana, Perez, Elena, Pollard, Andrew, Powrie, Fiona, Psaila, Bethan, Quan, T Phuong, Repapi, Emmanouela, Revale, Santiago, Silva-Reyes, Laura, Richard, Jean-Baptiste, Rich-Griffin, Charlotte, Ritter, Thomas, Rollier, Christine, Rowland, Matthew, Ruehle, Fabian, Salio, Mariolina, Sansom, Stephen Nicholas, Sanches Peres, Raphael, Santos Delgado, Alberto, Sauka-Spengler, Tatjana, Schwessinger, Ron, Scozzafava, Giuseppe, Screaton, Gavin, Seigal, Anna, Semple, Malcolm, Sergeant, Martin, Simoglou Karali, Christina, Sims, David, Skelly, Donal, Slawinski, Hubert, Sobrinodiaz, Alberto, Sousos, Nikolaos, Stafford, Lizzie, Stockdale, Lisa, Strickland, Marie, Sumray, Otto, Sun, Bo, Taylor, Chelsea, Taylor, Stephen, Taylor, Adan, Thongjuea, Supat, Thraves, Hannah, Todd, John, Tomic, Adriana, Tong, Orion, Trebes, Amy, Trzupek, Dominik, Tucci, Felicia Anna, Turtle, Lance, Udalova, Irina, Uhlig, Holm, van Grinsven, Erinke, Vendrell, Iolanda, Verheul, Marije, Voda, Alexandru, Wang, Guanlin, Wang, Lihui, Wang, Dapeng, Watkinson, Peter, Watson, Robert, Weinberger, Michael, Whalley, Justin, Witty, Lorna, Wray, Katherine, Xue, Luzheng, Yuen Yeung, Hing, Yin, Zixi, Young, Rebecca, Youngs, Jonathan, Zhang, Ping, Zurke, Yasemin-Xiomara, Banning, Adrian, Antonopoulos, Alexios, Bajaj, Amrita, Kelion, Andrew, Deshpande, Aparna, Kardos, Attila, Hudson, Benjamin, Koo, Bon-Kwon, Shirodaria, Cheerag, Xie, Cheng, Kotanidis, Christos, Mahon, Ciara, Berry, Colin, Adlam, David, Newby, David, Connolly, Derek, Scaletta, Diane, Alexander, Donna, Nicol, Ed, McAlindon, Elisa, Oikonomou, Evangelos, Pugliese, Francesca, Pontone, Gianluca, Benedetti, Giulia, He, Guo-Wei, West, Henry, Kondo, Hidekazu, Benedek, Imre, Das, Intrajeet, Deanfield, John, Graby, John, Greenwood, John, Rodrigues, Jonathan, Ge, Junbo, Channon, Keith, Fabritz, Larissa, Fan, Li-Juan, Kingham, Lucy, Guglielmo, Marco, Lyasheva, Maria, Schmitt, Matthias, Beer, Meinrad, Anderson, Michelle, Desai, Milind, Marwan, Mohamed, Takahashi, Naohiko, Mehta, Nehal, Dai, Neng, Screaton, Nicholas, Sabharwal, Nikant, Maurovich-Horvat, Pál, Rao, Praveen, Kotronias, Rafail, Kharbanda, Rajesh, Preston, Rebecca, Wood, Richard, Blankstein, Ron, Rajani, Ronak, Mirsadraee, Saeed, Munir, Shahzad, Thomas, Sheena, Neubauer, Stefan, Klömpken, Steffen, Petersen, Steffen, Achenbach, Stephan, Anthony, Susan, Mak, Sze, Mittal, Tarun, Benedek, Theodora, Sharma, Vinoda, Lin, Wen-Hua, Kotanidis, Christos P, Rodrigues, Jonathan C L, O’Connor, Daniel, Siddique, Muhammad, Lockstone, Helen, Oikonomou, Evangelos K, Badi, Ileana, Lumley, Sheila F, Constantinides, Bede, Sanderson, Nicholas, Rodger, Gillian, Chau, Kevin K, Lodge, Archie, Tsakok, Maria, Gleeson, Fergus, Indrajeet, Das, Hudson, Benjamin J, Srivastava, Vivek, Farid, Shakil, Krasopoulos, George, Sayeed, Rana, Newby, David E, Channon, Keith M, and Antoniades, Charalambos

Published
2022
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13. The extracellular heparan sulfatase SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis.

Author

Swart, Maarten, Redpath, Andia N., Ogbechi, Joy, Cardenas, Ryan, Topping, Louise, Compeer, Ewoud B., Goddard, Michael, Chanalaris, Anastasios, Williams, Richard, Brewer, Daniel S., Smart, Nicola, Monaco, Claudia, and Troeberg, Linda

Subjects
JOINT diseases, HEPARAN sulfate, BONE marrow, GROWTH factors, T helper cells, TYPE I interferons
Abstract

Heparan sulfate (HS) proteoglycans are important regulators of cellular responses to soluble mediators such as chemokines, cytokines and growth factors. We profiled changes in expression of genes encoding HS core proteins, biosynthesis enzymes and modifiers during macrophage polarisation, and found that the most highly regulated gene was Sulf2, an extracellular HS 6-O-sulfatase that was markedly downregulated in response to pro-inflammatory stimuli. We then generated Sulf2+/− bone marrow chimeric mice and examined inflammatory responses in antigen-induced arthritis, as a model of rheumatoid arthritis. Resolution of inflammation was impaired in myeloid Sulf2+/− chimeras, with elevated joint swelling and increased abundance of pro-arthritic Th17 cells in synovial tissue. Transcriptomic and in vitro analyses indicated that Sulf2 deficiency increased type I interferon signaling in bone marrow-derived macrophages, leading to elevated expression of the Th17-inducing cytokine IL6. This establishes that dynamic remodeling of HS by Sulf2 limits type I interferon signaling in macrophages, and so protects against Th17-driven pathology. [ABSTRACT FROM AUTHOR]

Published
2024
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15. The extracellular heparan sulfatase SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis

Author

Swart, Maarten, primary, Redpath, Andia, additional, Ogbechi, Joy, additional, Cardenas, Ryan, additional, Topping, Louise, additional, Compeer, Ewoud B., additional, Goddard, Michael, additional, Chanalaris, Anastasios, additional, Williams, Richard, additional, Brewer, Daniel S., additional, Smart, Nicola, additional, Monaco, Claudia, additional, and Troeberg, Linda, additional

Published
2024
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17. Posicionamento do Departamento de Imagem Cardiovascular da Sociedade Brasileira de Cardiologia sobre o Uso do Strain Miocárdico na Rotina do Cardiologista – 2023

Author

Almeida, André Luiz Cerqueira, primary, Melo, Marcelo Dantas Tavares de, additional, Bihan, David Costa de Souza Le, additional, Vieira, Marcelo Luiz Campos, additional, Pena, José Luiz Barros, additional, Del Castillo, José Maria, additional, Abensur, Henry, additional, Hortegal, Renato de Aguiar, additional, Otto, Maria Estefania Bosco, additional, Piveta, Rafael Bonafim, additional, Dantas, Maria Rosa, additional, Assef, Jorge Eduardo, additional, Beck, Adenalva Lima de Souza, additional, Santo, Thais Harada Campos Espirito, additional, Silva, Tonnison de Oliveira, additional, Salemi, Vera Maria Cury, additional, Rocon, Camila, additional, Lima, Márcio Silva Miguel, additional, Barberato, Silvio Henrique, additional, Rodrigues, Ana Clara, additional, Rabschkowisky, Arnaldo, additional, Frota, Daniela do Carmo Rassi, additional, Gripp, Eliza de Almeida, additional, Barretto, Rodrigo Bellio de Mattos, additional, Silva, Sandra Marques e, additional, Cauduro, Sanderson Antonio, additional, Pinheiro, Aurélio Carvalho, additional, Araujo, Salustiano Pereira de, additional, Tressino, Cintia Galhardo, additional, Silva, Carlos Eduardo Suaide, additional, Monaco, Claudia Gianini, additional, Paiva, Marcelo Goulart, additional, Fisher, Cláudio Henrique, additional, Alves, Marco Stephan Lofrano, additional, Grau, Cláudia R. Pinheiro de Castro, additional, Santos, Maria Veronica Camara dos, additional, Guimarães, Isabel Cristina Britto, additional, Morhy, Samira Saady, additional, Leal, Gabriela Nunes, additional, Soares, Andressa Mussi, additional, Cruz, Cecilia Beatriz Bittencourt Viana, additional, Guimarães, Fabio Villaça, additional, Assunção, Bruna Morhy Borges Leal, additional, Fernandes, Rafael Modesto, additional, Saraiva, Roberto Magalhães, additional, Tsutsui, Jeane Mike, additional, Soares, Fábio Luis de Jesus, additional, Falcão, Sandra Nívea dos Reis Saraiva, additional, Hotta, Viviane Tiemi, additional, Armstrong, Anderson da Costa, additional, Hygidio, Daniel de Andrade, additional, Miglioranza, Marcelo Haertel, additional, Camarozano, Ana Cristina, additional, Lopes, Marly Maria Uellendahl, additional, Cerci, Rodrigo Julio, additional, Siqueira, Maria Eduarda Menezes de, additional, Torreão, Jorge Andion, additional, Rochitte, Carlos Eduardo, additional, and Felix, Alex, additional

Published
2023
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19. Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells

Author

Engelen, Suzanne E., primary, Ververs, Francesca A., additional, Markovska, Angela, additional, Lagerholm, B. Christoffer, additional, Kraaijenhof, Jordan M., additional, Yousif, Laura I.E., additional, Zurke, Yasemin-Xiomara, additional, Gulersonmez, Can M.C., additional, Kooijman, Sander, additional, Goddard, Michael, additional, van Eijkeren, Robert J., additional, Jervis, Peter J., additional, Besra, Gurdyal S., additional, Haitjema, Saskia, additional, Asselbergs, Folkert W., additional, Kalkhoven, Eric, additional, Ploegh, Hidde L., additional, Boes, Marianne, additional, Cerundolo, Vincenzo, additional, Hovingh, G.K., additional, Salio, Mariolina, additional, Stigter, Edwin C.A., additional, Rensen, Patrick C.N., additional, Monaco, Claudia, additional, and Schipper, Henk S., additional

Published
2023
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20. Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk

Author

Forteza, Maria J, primary, Berg, Martin, additional, Edsfeldt, Andreas, additional, Sun, Jangming, additional, Baumgartner, Roland, additional, Kareinen, Ilona, additional, Casagrande, Felipe Beccaria, additional, Hedin, Ulf, additional, Zhang, Song, additional, Vuckovic, Ivan, additional, Dzeja, Petras P, additional, Polyzos, Konstantinos A, additional, Gisterå, Anton, additional, Trauelsen, Mette, additional, Schwartz, Thue W, additional, Dib, Lea, additional, Herrmann, Joerg, additional, Monaco, Claudia, additional, Matic, Ljubica, additional, Gonçalves, Isabel, additional, and Ketelhuth, Daniel F J, additional

Published
2023
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22. Translational opportunities of single-cell biology in atherosclerosis

Author

de Winther, Menno P J, primary, Bäck, Magnus, additional, Evans, Paul, additional, Gomez, Delphine, additional, Goncalves, Isabel, additional, Jørgensen, Helle F, additional, Koenen, Rory R, additional, Lutgens, Esther, additional, Norata, Giuseppe Danilo, additional, Osto, Elena, additional, Dib, Lea, additional, Simons, Michael, additional, Stellos, Konstantinos, additional, Ylä-Herttuala, Seppo, additional, Winkels, Holger, additional, Bochaton-Piallat, Marie-Luce, additional, and Monaco, Claudia, additional

Published
2022
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24. Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Author

Kotanidis, Christos P, primary, Xie, Cheng, additional, Alexander, Donna, additional, Rodrigues, Jonathan C L, additional, Burnham, Katie, additional, Mentzer, Alexander, additional, O’Connor, Daniel, additional, Knight, Julian, additional, Siddique, Muhammad, additional, Lockstone, Helen, additional, Thomas, Sheena, additional, Kotronias, Rafail, additional, Oikonomou, Evangelos K, additional, Badi, Ileana, additional, Lyasheva, Maria, additional, Shirodaria, Cheerag, additional, Lumley, Sheila F, additional, Constantinides, Bede, additional, Sanderson, Nicholas, additional, Rodger, Gillian, additional, Chau, Kevin K, additional, Lodge, Archie, additional, Tsakok, Maria, additional, Gleeson, Fergus, additional, Adlam, David, additional, Rao, Praveen, additional, Indrajeet, Das, additional, Deshpande, Aparna, additional, Bajaj, Amrita, additional, Hudson, Benjamin J, additional, Srivastava, Vivek, additional, Farid, Shakil, additional, Krasopoulos, George, additional, Sayeed, Rana, additional, Ho, Ling-Pei, additional, Neubauer, Stefan, additional, Newby, David E, additional, Channon, Keith M, additional, Deanfield, John, additional, Antoniades, Charalambos, additional, Ahern, David J, additional, Ai, Zhichao, additional, Ainsworth, Mark, additional, Allan, Chris, additional, Allcock, Alice, additional, Angus, Brian, additional, Ansari, M Azim, additional, Arancibia-Cárcamo, Carolina, additional, Aschenbrenner, Dominik, additional, Attar, Moustafa, additional, Baillie, J Kenneth, additional, Barnes, Eleanor, additional, Bashford-Rogers, Rachael, additional, Bashyal, Archana, additional, Beer, Sally, additional, Berridge, Georgina, additional, Beveridge, Amy, additional, Bibi, Sagida, additional, Bicanic, Tihana, additional, Blackwell, Luke, additional, Bowness, Paul, additional, Brent, Andrew, additional, Brown, Andrew, additional, Broxholme, John, additional, Buck, David, additional, Byrne, Helen, additional, Camara, Susana, additional, Ferreira, Ivan Candido, additional, Charles, Philip, additional, Chen, Wentao, additional, Chen, Yi-Ling, additional, Chong, Amanda, additional, Clutterbuck, Elizabeth, additional, Coles, Mark, additional, Conlon, Christopher, additional, Cornall, Richard, additional, Cribbs, Adam, additional, Curion, Fabiola, additional, Davenport, Emma, additional, Davidson, Neil, additional, Davis, Simon, additional, Dendrou, Calliope, additional, Dequaire, Julie, additional, Dib, Lea, additional, Docker, James, additional, Dold, Christina, additional, Dong, Tao, additional, Downes, Damien, additional, Drakesmith, Hal, additional, Dunachie, Susanna, additional, Duncan, David, additional, Eijsbouts, Chris, additional, Esnouf, Robert, additional, Espinosa, Alexis, additional, Etherington, Rachel, additional, Fairfax, Benjamin, additional, Fairhead, Rory, additional, Fang, Hai, additional, Fassih, Shayan, additional, Felle, Sally, additional, Fernandez Mendoza, Maria, additional, Ferreira, Ricardo, additional, Fischer, Roman, additional, Foord, Thomas, additional, Forrow, Aden, additional, Frater, John, additional, Fries, Anastasia, additional, Gallardo Sanchez, Veronica, additional, Garner, Lucy, additional, Geeves, Clementine, additional, Georgiou, Dominique, additional, Godfrey, Leila, additional, Golubchik, Tanya, additional, Gomez Vazquez, Maria, additional, Green, Angie, additional, Harper, Hong, additional, Harrington, Heather, additional, Heilig, Raphael, additional, Hester, Svenja, additional, Hill, Jennifer, additional, Hinds, Charles, additional, Hird, Clare, additional, Hoekzema, Renee, additional, Hollis, Benjamin, additional, Hughes, Jim, additional, Hutton, Paula, additional, Jackson-Wood, Matthew, additional, Jainarayanan, Ashwin, additional, James-Bott, Anna, additional, Jansen, Kathrin, additional, Jeffery, Katie, additional, Jones, Elizabeth, additional, Jostins, Luke, additional, Kerr, Georgina, additional, Kim, David, additional, Klenerman, Paul, additional, Kumar, Vinod, additional, Kumar Sharma, Piyush, additional, Kurupati, Prathiba, additional, Kwok, Andrew, additional, Lee, Angela, additional, Linder, Aline, additional, Lockett, Teresa, additional, Lonie, Lorne, additional, Lopopolo, Maria, additional, Lukoseviciute, Martyna, additional, Luo, Jian, additional, Marinou, Spyridoula, additional, Marsden, Brian, additional, Martinez, Jose, additional, Matthews, Philippa, additional, Mazurczyk, Michalina, additional, McGowan, Simon, additional, McKechnie, Stuart, additional, Mead, Adam, additional, Mi, Yuxin, additional, Monaco, Claudia, additional, Montadon, Ruddy, additional, Napolitani, Giorgio, additional, Nassiri, Isar, additional, Novak, Alex, additional, O'Brien, Darragh, additional, O'Connor, Daniel, additional, O'Donnell, Denise, additional, Ogg, Graham, additional, Overend, Lauren, additional, Park, Inhye, additional, Pavord, Ian, additional, Peng, Yanchun, additional, Penkava, Frank, additional, Pereira Pinho, Mariana, additional, Perez, Elena, additional, Pollard, Andrew, additional, Powrie, Fiona, additional, Psaila, Bethan, additional, Quan, T Phuong, additional, Repapi, Emmanouela, additional, Revale, Santiago, additional, Silva-Reyes, Laura, additional, Richard, Jean-Baptiste, additional, Rich-Griffin, Charlotte, additional, Ritter, Thomas, additional, Rollier, Christine, additional, Rowland, Matthew, additional, Ruehle, Fabian, additional, Salio, Mariolina, additional, Sansom, Stephen Nicholas, additional, Sanches Peres, Raphael, additional, Santos Delgado, Alberto, additional, Sauka-Spengler, Tatjana, additional, Schwessinger, Ron, additional, Scozzafava, Giuseppe, additional, Screaton, Gavin, additional, Seigal, Anna, additional, Semple, Malcolm, additional, Sergeant, Martin, additional, Simoglou Karali, Christina, additional, Sims, David, additional, Skelly, Donal, additional, Slawinski, Hubert, additional, Sobrinodiaz, Alberto, additional, Sousos, Nikolaos, additional, Stafford, Lizzie, additional, Stockdale, Lisa, additional, Strickland, Marie, additional, Sumray, Otto, additional, Sun, Bo, additional, Taylor, Chelsea, additional, Taylor, Stephen, additional, Taylor, Adan, additional, Thongjuea, Supat, additional, Thraves, Hannah, additional, Todd, John, additional, Tomic, Adriana, additional, Tong, Orion, additional, Trebes, Amy, additional, Trzupek, Dominik, additional, Tucci, Felicia Anna, additional, Turtle, Lance, additional, Udalova, Irina, additional, Uhlig, Holm, additional, van Grinsven, Erinke, additional, Vendrell, Iolanda, additional, Verheul, Marije, additional, Voda, Alexandru, additional, Wang, Guanlin, additional, Wang, Lihui, additional, Wang, Dapeng, additional, Watkinson, Peter, additional, Watson, Robert, additional, Weinberger, Michael, additional, Whalley, Justin, additional, Witty, Lorna, additional, Wray, Katherine, additional, Xue, Luzheng, additional, Yuen Yeung, Hing, additional, Yin, Zixi, additional, Young, Rebecca, additional, Youngs, Jonathan, additional, Zhang, Ping, additional, Zurke, Yasemin-Xiomara, additional, Banning, Adrian, additional, Antonopoulos, Alexios, additional, Kelion, Andrew, additional, Kardos, Attila, additional, Hudson, Benjamin, additional, Koo, Bon-Kwon, additional, Kotanidis, Christos, additional, Mahon, Ciara, additional, Berry, Colin, additional, Newby, David, additional, Connolly, Derek, additional, Scaletta, Diane, additional, Nicol, Ed, additional, McAlindon, Elisa, additional, Oikonomou, Evangelos, additional, Pugliese, Francesca, additional, Pontone, Gianluca, additional, Benedetti, Giulia, additional, He, Guo-Wei, additional, West, Henry, additional, Kondo, Hidekazu, additional, Benedek, Imre, additional, Das, Intrajeet, additional, Graby, John, additional, Greenwood, John, additional, Rodrigues, Jonathan, additional, Ge, Junbo, additional, Channon, Keith, additional, Fabritz, Larissa, additional, Fan, Li-Juan, additional, Kingham, Lucy, additional, Guglielmo, Marco, additional, Schmitt, Matthias, additional, Beer, Meinrad, additional, Anderson, Michelle, additional, Desai, Milind, additional, Marwan, Mohamed, additional, Takahashi, Naohiko, additional, Mehta, Nehal, additional, Dai, Neng, additional, Screaton, Nicholas, additional, Sabharwal, Nikant, additional, Maurovich-Horvat, Pál, additional, Kharbanda, Rajesh, additional, Preston, Rebecca, additional, Wood, Richard, additional, Blankstein, Ron, additional, Rajani, Ronak, additional, Mirsadraee, Saeed, additional, Munir, Shahzad, additional, Klömpken, Steffen, additional, Petersen, Steffen, additional, Achenbach, Stephan, additional, Anthony, Susan, additional, Mak, Sze, additional, Mittal, Tarun, additional, Benedek, Theodora, additional, Sharma, Vinoda, additional, and Lin, Wen-Hua, additional

Published
2022
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25. Preclinical Aortic Atherosclerosis in Adolescents With Chronic Disease

Author

Ververs, Francesca A., primary, Eikendal, Anouk L. M., additional, Kofink, Daniel, additional, Nuboer, Roos, additional, Westenberg, Jos J. M., additional, Hovenkamp, Gijs T., additional, Kemps, Jitske J.A., additional, Coenen, Iris C. J., additional, Daems, Joëlle J. N., additional, Claus, Laura R., additional, Ju, Yillie, additional, Wulffraat, Nico M., additional, van der Ent, Cornelis K., additional, Monaco, Claudia, additional, Boes, Marianne, additional, Leiner, Tim, additional, Grotenhuis, Heynric B., additional, and Schipper, Henk S., additional

Published
2022
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26. Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state.

Author

Bosmans, Laura A, Tiel, Claudia M van, Aarts, Suzanne A B M, Willemsen, Lisa, Baardman, Jeroen, Os, Bram W van, Toom, Myrthe den, Beckers, Linda, Ahern, David J, Levels, Johannes H M, Jongejan, Aldo, Moerland, Perry D, Verberk, Sanne G S, van den Bossche, Jan, Winther, Menno M P J de, Weber, Christian, Atzler, Dorothee, Monaco, Claudia, Gerdes, Norbert, and Shami, Annelie

Subjects
INFLAMMATION, ATHEROSCLEROTIC plaque, MYELOID cells, ATHEROSCLEROSIS, MACROPHAGES, CYTOMETRY
Abstract

Aims CD40 and its ligand, CD40L, play a critical role in driving atherosclerotic plaque development. Disrupted CD40-signalling reduces experimental atherosclerosis and induces a favourable stable plaque phenotype. We recently showed that small molecule-based inhibition of CD40-tumour necrosis factor receptor associated factor-6 interactions attenuates atherosclerosis in hyperlipidaemic mice via macrophage-driven mechanisms. The present study aims to detail the function of myeloid CD40 in atherosclerosis using myeloid-specific CD40-deficient mice. Method and Results Cd40flox/flox and LysM-cre Cd40flox/flox mice on an Apoe−/− background were generated (CD40wt and CD40mac−/− , respectively). Atherosclerotic lesion size, as well as plaque macrophage content, was reduced in CD40mac−/− compared to CD40wt mice, and their plaques displayed a reduction in necrotic core size. Transcriptomics analysis of the CD40mac−/− atherosclerotic aorta revealed downregulated pathways of immune pathways and inflammatory responses. Loss of CD40 in macrophages changed the representation of aortic macrophage subsets. Mass cytometry analysis revealed a higher content of a subset of alternative or resident-like CD206+CD209b− macrophages in the atherosclerotic aorta of CD40mac−/− compared to CD40wt mice. RNA-sequencing of bone marrow-derived macrophages of CD40mac−/− mice demonstrated upregulation of genes associated with alternatively activated macrophages (including Folr2 , Thbs1 , Sdc1 , and Tns1). Conclusions We here show that absence of CD40 signalling in myeloid cells reduces atherosclerosis and limits systemic inflammation by preventing a shift in macrophage polarization towards pro-inflammatory states. Our study confirms the merit of macrophage-targeted inhibition of CD40 as a valuable therapeutic strategy to combat atherosclerosis. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Translational opportunities of single-cell biology in atherosclerosis.

Author

Winther, Menno P J de, Bäck, Magnus, Evans, Paul, Gomez, Delphine, Goncalves, Isabel, Jørgensen, Helle F, Koenen, Rory R, Lutgens, Esther, Norata, Giuseppe Danilo, Osto, Elena, Dib, Lea, Simons, Michael, Stellos, Konstantinos, Ylä-Herttuala, Seppo, Winkels, Holger, Bochaton-Piallat, Marie-Luce, and Monaco, Claudia

Subjects
BIOLOGY, CARDIOVASCULAR diseases, INTERNATIONAL relations, MUSCLE cells, PATIENT care
Abstract

The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state

Author

Bosmans, Laura A, primary, van Tiel, Claudia M, additional, Aarts, Suzanne A B M, additional, Willemsen, Lisa, additional, Baardman, Jeroen, additional, van Os, Bram W, additional, Toom, Myrthe den, additional, Beckers, Linda, additional, Ahern, David J, additional, Levels, Johannes H M, additional, Jongejan, Aldo, additional, Moerland, Perry D, additional, Verberk, Sanne G S, additional, den Bossche, Jan van, additional, de Winther, Menno M P J, additional, Weber, Christian, additional, Atzler, Dorothee, additional, Monaco, Claudia, additional, Gerdes, Norbert, additional, Shami, Annelie, additional, and Lutgens, Esther, additional

Published
2022
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29. Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model

Author

Arora, Aastha, primary, Tripodi, Gustavo Luis, additional, Kareinen, Ilona, additional, Berg, Martin, additional, Forteza, Maria Josefa, additional, Gisterå, Anton, additional, Griepke, Silke, additional, Casagrande, Felipe Beccaria, additional, Martins, Joilson O., additional, Abdalla, Dulcineia Saes Parra, additional, Cole, Jennifer, additional, Monaco, Claudia, additional, and Ketelhuth, Daniel F. J., additional

Published
2022
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30. A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Author

Ahern, David J., primary, Ai, Zhichao, additional, Ainsworth, Mark, additional, Allan, Chris, additional, Allcock, Alice, additional, Angus, Brian, additional, Ansari, M. Azim, additional, Arancibia-Cárcamo, Carolina V., additional, Aschenbrenner, Dominik, additional, Attar, Moustafa, additional, Baillie, J. Kenneth, additional, Barnes, Eleanor, additional, Bashford-Rogers, Rachael, additional, Bashyal, Archana, additional, Beer, Sally, additional, Berridge, Georgina, additional, Beveridge, Amy, additional, Bibi, Sagida, additional, Bicanic, Tihana, additional, Blackwell, Luke, additional, Bowness, Paul, additional, Brent, Andrew, additional, Brown, Andrew, additional, Broxholme, John, additional, Buck, David, additional, Burnham, Katie L., additional, Byrne, Helen, additional, Camara, Susana, additional, Candido Ferreira, Ivan, additional, Charles, Philip, additional, Chen, Wentao, additional, Chen, Yi-Ling, additional, Chong, Amanda, additional, Clutterbuck, Elizabeth A., additional, Coles, Mark, additional, Conlon, Christopher P., additional, Cornall, Richard, additional, Cribbs, Adam P., additional, Curion, Fabiola, additional, Davenport, Emma E., additional, Davidson, Neil, additional, Davis, Simon, additional, Dendrou, Calliope A., additional, Dequaire, Julie, additional, Dib, Lea, additional, Docker, James, additional, Dold, Christina, additional, Dong, Tao, additional, Downes, Damien, additional, Drakesmith, Hal, additional, Dunachie, Susanna J., additional, Duncan, David A., additional, Eijsbouts, Chris, additional, Esnouf, Robert, additional, Espinosa, Alexis, additional, Etherington, Rachel, additional, Fairfax, Benjamin, additional, Fairhead, Rory, additional, Fang, Hai, additional, Fassih, Shayan, additional, Felle, Sally, additional, Fernandez Mendoza, Maria, additional, Ferreira, Ricardo, additional, Fischer, Roman, additional, Foord, Thomas, additional, Forrow, Aden, additional, Frater, John, additional, Fries, Anastasia, additional, Gallardo Sanchez, Veronica, additional, Garner, Lucy C., additional, Geeves, Clementine, additional, Georgiou, Dominique, additional, Godfrey, Leila, additional, Golubchik, Tanya, additional, Gomez Vazquez, Maria, additional, Green, Angie, additional, Harper, Hong, additional, Harrington, Heather A., additional, Heilig, Raphael, additional, Hester, Svenja, additional, Hill, Jennifer, additional, Hinds, Charles, additional, Hird, Clare, additional, Ho, Ling-Pei, additional, Hoekzema, Renee, additional, Hollis, Benjamin, additional, Hughes, Jim, additional, Hutton, Paula, additional, Jackson-Wood, Matthew A., additional, Jainarayanan, Ashwin, additional, James-Bott, Anna, additional, Jansen, Kathrin, additional, Jeffery, Katie, additional, Jones, Elizabeth, additional, Jostins, Luke, additional, Kerr, Georgina, additional, Kim, David, additional, Klenerman, Paul, additional, Knight, Julian C., additional, Kumar, Vinod, additional, Kumar Sharma, Piyush, additional, Kurupati, Prathiba, additional, Kwok, Andrew, additional, Lee, Angela, additional, Linder, Aline, additional, Lockett, Teresa, additional, Lonie, Lorne, additional, Lopopolo, Maria, additional, Lukoseviciute, Martyna, additional, Luo, Jian, additional, Marinou, Spyridoula, additional, Marsden, Brian, additional, Martinez, Jose, additional, Matthews, Philippa C., additional, Mazurczyk, Michalina, additional, McGowan, Simon, additional, McKechnie, Stuart, additional, Mead, Adam, additional, Mentzer, Alexander J., additional, Mi, Yuxin, additional, Monaco, Claudia, additional, Montadon, Ruddy, additional, Napolitani, Giorgio, additional, Nassiri, Isar, additional, Novak, Alex, additional, O'Brien, Darragh P., additional, O'Connor, Daniel, additional, O'Donnell, Denise, additional, Ogg, Graham, additional, Overend, Lauren, additional, Park, Inhye, additional, Pavord, Ian, additional, Peng, Yanchun, additional, Penkava, Frank, additional, Pereira Pinho, Mariana, additional, Perez, Elena, additional, Pollard, Andrew J., additional, Powrie, Fiona, additional, Psaila, Bethan, additional, Quan, T. Phuong, additional, Repapi, Emmanouela, additional, Revale, Santiago, additional, Silva-Reyes, Laura, additional, Richard, Jean-Baptiste, additional, Rich-Griffin, Charlotte, additional, Ritter, Thomas, additional, Rollier, Christine S., additional, Rowland, Matthew, additional, Ruehle, Fabian, additional, Salio, Mariolina, additional, Sansom, Stephen Nicholas, additional, Sanches Peres, Raphael, additional, Santos Delgado, Alberto, additional, Sauka-Spengler, Tatjana, additional, Schwessinger, Ron, additional, Scozzafava, Giuseppe, additional, Screaton, Gavin, additional, Seigal, Anna, additional, Semple, Malcolm G., additional, Sergeant, Martin, additional, Simoglou Karali, Christina, additional, Sims, David, additional, Skelly, Donal, additional, Slawinski, Hubert, additional, Sobrinodiaz, Alberto, additional, Sousos, Nikolaos, additional, Stafford, Lizzie, additional, Stockdale, Lisa, additional, Strickland, Marie, additional, Sumray, Otto, additional, Sun, Bo, additional, Taylor, Chelsea, additional, Taylor, Stephen, additional, Taylor, Adan, additional, Thongjuea, Supat, additional, Thraves, Hannah, additional, Todd, John A., additional, Tomic, Adriana, additional, Tong, Orion, additional, Trebes, Amy, additional, Trzupek, Dominik, additional, Tucci, Felicia Anna, additional, Turtle, Lance, additional, Udalova, Irina, additional, Uhlig, Holm, additional, van Grinsven, Erinke, additional, Vendrell, Iolanda, additional, Verheul, Marije, additional, Voda, Alexandru, additional, Wang, Guanlin, additional, Wang, Lihui, additional, Wang, Dapeng, additional, Watkinson, Peter, additional, Watson, Robert, additional, Weinberger, Michael, additional, Whalley, Justin, additional, Witty, Lorna, additional, Wray, Katherine, additional, Xue, Luzheng, additional, Yeung, Hing Yuen, additional, Yin, Zixi, additional, Young, Rebecca K., additional, Youngs, Jonathan, additional, Zhang, Ping, additional, and Zurke, Yasemin-Xiomara, additional

Published
2022
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31. Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture–prone atherosclerotic plaques

Author

Edsfeldt, Andreas, primary, Swart, Maarten, additional, Singh, Pratibha, additional, Dib, Lea, additional, Sun, Jiangming, additional, Cole, Jennifer E, additional, Park, Inhye, additional, Al-Sharify, Dania, additional, Persson, Ana, additional, Nitulescu, Mihaela, additional, Borges, Patricia Das Neves, additional, Kassiteridi, Christina, additional, Goddard, Michael E, additional, Lee, Regent, additional, Volkov, Petr, additional, Orho-Melander, Marju, additional, Maegdefessel, Lars, additional, Nilsson, Jan, additional, Udalova, Irina, additional, Goncalves, Isabel, additional, and Monaco, Claudia, additional

Published
2022
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33. Transcriptomic-based clustering of advanced atherosclerotic plaques identifies subgroups of plaques with differential underlying biology that associate with clinical presentation

Author

Mokry, Michal, primary, Boltjes, Arjan, additional, Cui, Kai, additional, Slenders, Lotte, additional, Mekke, Joost M., additional, depuydt, Marie A.C., additional, Timmerman, Nathalie M., additional, Waissi, Farahnaz, additional, Verwer, Maarten C., additional, Turner, Adam W., additional, Khan, Mohammad D., additional, Hodonsky, Chani J., additional, Diez Benavente, Ernest, additional, Hartman, Robin J. G., additional, van den Dungen, Noortje A. M., additional, Lansu, Nico, additional, Nagyova, Emilia, additional, Prange, Koen H. M., additional, Pavlos, Eleftherios, additional, Andreakos, Evangelos, additional, Schunkert, Heribert, additional, Owens, Gary K., additional, Monaco, Claudia, additional, Finn, Aloke V., additional, Virmani, Renu, additional, Leeper, Nicholas J., additional, de Winther, Menno P. J., additional, Kuiper, Johan, additional, de Borst, Gert J., additional, Stroes, Erik S. G., additional, Civelek, Mete, additional, de Kleijn, Dominique P. V., additional, den Ruijter, Hester M., additional, Asselbergs, Folkert W., additional, van der Laan, Sander W., additional, Miller, Clint L., additional, and Pasterkamp, Gerard, additional

Published
2021
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35. The role of natural killer T cells in atherosclerosis

Author

Engelen, Suzanne, Monaco, Claudia, Buckley, Christopher, and Schipper, Hendrik

Abstract

Atherosclerosis is a multifactorial, chronic inflammatory disease of the arterial wall starting in childhood. It is characterised by the gradual formation of lipid-, connective tissue- and immune cell containing plaques. The interplay between lipids and the immune system has proven key in its development. Natural Killer T (NKT) cells are at the interface between lipid metabolism and immunity, due to their restriction to lipid antigen-mediated activation by antigen presenting cells (APC). Although considered pro-atherogenic in mouse, the mechanisms involved in NKT cell activation in humans remain elusive and their role in human cardiovascular disease requires further study. In this thesis, I identify lipoproteins very-low-density- (VLDL) and low-density (LDL) as vehicles for lipid antigen delivery and subsequent activation of invariant NKT cells. In the circulation, model lipid antigens bind to VLDL and LDL. Subsequent uptake by APCs is LDL-receptor (LDLR)-mediated, demonstrated in vitro and in vivo in mouse models. As a consequence, LDLR-mutant APCs of patients with familial hypercholesterolemia are impaired in their ability to activate invariant NKT cells, validating this mechanism in a human context. Moreover, the relation of NKT cell plaque-abundance with clinical outcome, patient- and plaque characteristics was studied in a human cohort. NKT cell abundance in plaques is inversely associated with plaque vulnerability, suggesting a protective role for NKT cells in stabilisation of the human plaque. Evidence of APC-NKT cell interaction in human atherosclerosis is currently lacking. To this end, I applied Hyperion Imaging Mass Cytometry (IMC) to human atherosclerotic plaques to study the NKT cell niche, revealing spatial evidence in situ of close cellular interactions of macrophages and NKT cells. In conclusion, this thesis defines the mechanism of lipid antigen delivery to APCs by circulating lipoproteins, and its fundamental role in invariant NKT cell activation. It proposes innovative imaging modalities to study the APC-iNKT axis in the human plaque, and associates NKT plaque-abundance with clinical parameters for the first time. These novel insights further our understanding of the interplay of lipids and the immune system, underlying atherosclerosis.

Published
2022

36. Position Statement on the Use of Myocardial Strain in Cardiology Routines by the Brazilian Society of Cardiology's Department Of Cardiovascular Imaging - 2023.

Author

Almeida ALC, Melo MDT, Bihan DCSL, Vieira MLC, Pena JLB, Del Castillo JM, Abensur H, Hortegal RA, Otto MEB, Piveta RB, Dantas MR, Assef JE, Beck ALS, Santo THCE, Silva TO, Salemi VMC, Rocon C, Lima MSM, Barberato SH, Rodrigues AC, Rabschkowisky A, Frota DDCR, Gripp EA, Barretto RBM, Silva SME, Cauduro SA, Pinheiro AC, Araujo SP, Tressino CG, Silva CES, Monaco CG, Paiva MG, Fisher CH, Alves MSL, Grau CRPC, Santos MVCD, Guimarães ICB, Morhy SS, Leal GN, Soares AM, Cruz CBBV, Guimarães Filho FV, Assunção BMBL, Fernandes RM, Saraiva RM, Tsutsui JM, Soares FLJ, Falcão SNDRS, Hotta VT, Armstrong ADC, Hygidio DA, Miglioranza MH, Camarozano AC, Lopes MMU, Cerci RJ, Siqueira MEM, Torreão JA, Rochitte CE, and Felix A

Subjects
Humans, Echocardiography, Doppler, Brazil, Heart Atria diagnostic imaging, Ventricular Function, Left, Atrial Fibrillation diagnostic imaging, Cardiology, Ventricular Dysfunction, Left
Abstract

Central Illustration : Position Statement on the Use of Myocardial Strain in Cardiology Routines by the Brazilian Society of Cardiology's Department Of Cardiovascular Imaging - 2023 Proposal for including strain in the integrated diastolic function assessment algorithm, adapted from Nagueh et al.67 Am: mitral A-wave duration; Ap: reverse pulmonary A-wave duration; DD: diastolic dysfunction; LA: left atrium; LASr: LA strain reserve; LVGLS: left ventricular global longitudinal strain; TI: tricuspid insufficiency. Confirm concentric remodeling with LVGLS. In LVEF, mitral E wave deceleration time < 160 ms and pulmonary S-wave < D-wave are also parameters of increased filling pressure. This algorithm does not apply to patients with atrial fibrillation (AF), mitral annulus calcification, > mild mitral valve disease, left bundle branch block, paced rhythm, prosthetic valves, or severe primary pulmonary hypertension.

Published
2023
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37. Cell selectivity in succinate receptor SUCNR1 /GPR91 signaling in skeletal muscle.

Author

Abdelmoez AM, Dmytriyeva O, Zurke YX, Trauelsen M, Marica AA, Savikj M, Smith JAB, Monaco C, Schwartz TW, Krook A, and Pillon NJ

Subjects
Humans, Muscles metabolism, Obesity metabolism, Signal Transduction, Receptors, G-Protein-Coupled genetics, Receptors, G-Protein-Coupled metabolism, Succinic Acid metabolism
Abstract

Succinate is released by skeletal muscle during exercise and activates SUCNR1 /GPR91. Signaling of SUCNR1 is involved in metabolite-sensing paracrine communication in skeletal muscle during exercise. However, the specific cell types responding to succinate and the directionality of communication are unclear. We aim to characterize the expression of SUCNR1 in human skeletal muscle. De novo analysis of transcriptomic datasets demonstrated that SUCNR1 mRNA is expressed in immune, adipose, and liver tissues, but scarce in skeletal muscle. In human tissues, SUCNR1 mRNA was associated with macrophage markers. Single-cell RNA sequencing and fluorescent RNAscope demonstrated that in human skeletal muscle, SUCNR1 mRNA is not expressed in muscle fibers but coincided with macrophage populations. Human M2-polarized macrophages exhibit high levels of SUCNR1 mRNA and stimulation with selective agonists of SUCNR1 triggered Gq- and Gi-coupled signaling. Primary human skeletal muscle cells were unresponsive to SUCNR1 agonists. In conclusion, SUCNR1 is not expressed in muscle cells and its role in the adaptive response of skeletal muscle to exercise is most likely mediated via paracrine mechanisms involving M2-like macrophages within the muscle. NEW & NOTEWORTHY Macrophages but not skeletal muscle cells respond to extracellular succinate via SUCNR1/GPR91.

Published
2023
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38. Erratum: Author Correction: Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications.

Author

Dib L, Koneva LA, Edsfeldt A, Zurke YX, Sun J, Nitulescu M, Attar M, Lutgens E, Schmidt S, Lindholm MW, Choudhury RP, Cassimjee I, Lee R, Handa A, Goncalves I, Sansom SN, and Monaco C

Abstract

[This corrects the article DOI: 10.1038/s44161-023-00295-x.]., (© The Author(s) 2023.)

Published
2023
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39. Evaluation of the myocardial deformation in the diagnosis of rejection after heart transplantation.

Author

da Costa RCPL, Rodrigues ACT, Vieira MLC, Fischer CH, Monaco CG, Filho EBL, Bacal F, Caixeta A, and Morhy SS

Abstract

Introduction: Heart transplantation represents main therapy for end-stage heart failure. However, survival after transplantation is limited by development of graft rejection. Endomyocardial biopsy, an invasive and expensive procedure, is gold standard technique for diagnosis of rejection. Most of biopsy complications are observed using echocardiography. Novel echocardiographic techniques, such as myocardial strain and three-dimensional reconstruction, can be useful in heart transplant patients., Purpose: To evaluate ventricular strain in heart transplant patients and association with rejection, cellular or humoral, as well as two- and three-dimensional echocardiographic parameters., Methods: Cohort of patients from heart transplant program taken to echocardiography after endomyocardial biopsy, from December 2017 to January 2020. Ventricular strain and three-dimensional left ventricle parameters were studied. Rejection results were retrieved from medical record. Qualitative variables were expressed by absolute frequency and percentages, while continuous variables by means and standard deviations. Association between rejection and variables of interest was measured by odds ratio and confidence interval of 95%, with p -value < 0.05., Results: 123 post-endomyocardial biopsy echocardiographic exams were performed in 54 patients. Eighteen exams were excluded, lasting 105 exams to be evaluated for conventional and advanced echocardiographic parameters. Male patients were 60.4%. Prevalence of cellular rejection was 8.6%, humoral rejection 12.4%, and rejection of any type 20%. There was no association between right ventricular strain and rejection, whether cellular ( p = 0.118 and p = 0.227 for septum and free wall, respectively), humoral ( p = 0.845 and p = 0.283, respectively), or of any type (0.504 and 0.446). There was no correlation between rejection and left ventricle global longitudinal strain, three-dimensional ejection fraction or desynchrony index. Conventional parameters associated to rejection were left ventricle posterior wall thickness [OR 1.660 (1.163; 2.370), p = 0.005] and left ventricle mass index [OR 1.027 (1.011; 1.139), p = 0.001]. Left ventricle posterior wall thickness remained significant after analysis of cellular and humoral rejection separately [OR 1.825 (1.097; 3.036), p = 0.021 and OR 1.650 (1.028; 2.648), p = 0.038, respectively]., Conclusions: There was no association between ventricular strain, three-dimensional left ventricular ejection fraction and the desynchrony index and rejection, cellular or humoral. Evidence of association of graft rejection with left ventricle posterior wall thickness and left ventricle mass index was observed., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Costa, Rodrigues, Vieira, Fischer, Monaco, Filho, Bacal, Caixeta and Morhy.)

Published
2022
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