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This study investigated the impact of a cylindrical obstacle on convection in an inclined square cavity filled with water-Al2O3 nanofluid. Using the finite volume method, the problem was resolved by having the inner cylinder rotate adiabatically while other walls were thermally insulated. Additionally, the bottom wall was hotter than the top. The study examined the effects of cylindrical obstacle radius (0.1 ≤ R ≤ 0.2), rotation speed (-500 ≤ Ω ≤ 500), Richardson number (0.01 ≤ Ri ≤ 100), volumetric nanoparticle fraction (0.02), and Grashof number (Gr = 104 ) on heat transfer rate or Nusselt number. The results were compared with previous literature, and the influence of the cylindrical obstacle rotational speed on convection flow was evaluated. An increase in the counterclockwise angular rotating speed resulted in higher nanofluid flux. The heat transmission coefficient increased as the Richardson number decreased. The use of nanofluid in the enclosure increased the coefficient of heat flow through mixed convection. Finally, the study showed that the convection heat exchange is enhanced with the increase in the radius. Moreover, an enhancement of the Nusselt number around 46% was reported for the cylinder, under Gr=10000, ∅=0.02, =45° and Ri= 10.

Nowadays, innovative biodegradable packaging based on pH-sensitive natural dyes is being developed. These smart systems quickly inform the food quality to the consumer and monitor fresh foods in real-time. Smart packaging protects food against ambiance risks and simultaneously sends information to users for variations and alterations in the packaging settings. Anthocyanin (ACY), among the natural dyes used as indicators serves as water-soluble flavonoid pigments which made reflection in light in the red-blue range and can detect chemical and microbial alterations in foods based on their pH-susceptible conditions; on the other hand, they have considerable antimicrobial and antioxidant functions that result in the longer shelf life of food products. They also have beneficial properties including anti-cancer and anti-inflammatory functions, avoidance of heart diseases, overweight, and diabetes. Hence, this paper deals with the characteristics of smart packaging films based on anthocyanins, as well as their application in various food industries.

Neuroblastoma is a cancer that occurs due to abnormal development of the sympathetic nervous system. The dysregulation of miR-9 and miR-222 plays a crucial role in neuroblastoma development. These microRNAs have a significant relationship with PTEN, caspase-9, and MMP14, which can potentially form the basis for the specific diagnosis and treatment of this disease. In our study, two neuroblastoma cell lines were divided into three groups based on whether they had been treated with miR-9, anti-miR-9, miR-222, or both. We evaluated various parameters in these groups, including migration (through a wound healing assay), apoptosis (using flow cytometry), and gene expression (through qRT-PCR). Additionally, we measured the expression levels of MMP14, miR-9, and miR-222 in plasma and CSF samples from neuroblastoma patients using ELISA and qRT-PCR. We found that patients with neuroblastoma had higher levels of MMP14 and miR-222 mRNA expression but lower levels of miR-9 mRNA expression. Furthermore, after treating the cell lines with anti-miR-9 and anti-miR-222, we observed increased levels of MMP14 expression, as well as PTEN and caspase-9. Additionally, the treatment with anti-miR-222 and anti-miR-9 led to an increase in the frequency of apoptosis and migration of cancer cells. Our research shows that the dysregulation of miR-9, miR-222, and MMP14 could be key indicators in the pathogenesis of neuroblastoma. We also found that up-regulation of miR-9 was associated with decreased disease severity, whereas up-regulation of miR-222 and MMP14 was linked to increased disease severity., Competing Interests: Compliance with Ethical Standards. Conflict of Interest: The authors declare no competing interests. Consent to Participate: Written informed consent was obtained from all subjects before the study. Ethical Approval: This study was performed per the principles of the Declaration of Helsinki and the related ethics committee., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)