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134 results on '"Moffatt, Lauren T."'

4. Inhalation Injury is Associated with Endotheliopathy and Abnormal Fibrinolytic Phenotypes in Burn Patients: A Cohort Study

Author

Keyloun, John W, Le, Tuan D, Brummel-Ziedins, Kathleen E, Mclawhorn, Melissa M, Bravo, Maria C, Orfeo, Thomas, Johnson, Laura S, Moffatt, Lauren T, Pusateri, Anthony E, Shupp, Jeffrey W, McLawhorn, Melissa M, Callcut, Rachael A, Cohen, Mitchell J, Petzold, Linda R, Varner, Jeffrey D, Bravo, Maria Cristina, Freeman, Kalev, Mann, Kenneth G, Gautam, Aarti, Hammamieh, Rasha, and Jett, Marti

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Hematology, Physical Injury - Accidents and Adverse Effects, Clinical Research, Good Health and Well Being, Burns, Cohort Studies, Female, Humans, Male, Phenotype, Retrospective Studies, Thrombelastography, SYSCOT Study Group, Emergency & Critical Care Medicine, Clinical sciences, Allied health and rehabilitation science, Nursing
Abstract

Burn injury is associated with endothelial dysfunction and coagulopathy and concomitant inhalation injury (IHI) increases morbidity and mortality. The aim of this work is to identify associations between IHI, coagulation homeostasis, vascular endothelium, and clinical outcomes in burn patients. One hundred and twelve patients presenting to a regional burn center were included in this retrospective cohort study. Whole blood was collected at set intervals from admission through 24 hours and underwent viscoelastic assay with rapid thromboelastography (rTEG). Syndecan-1 (SDC-1) on admission was quantified by ELISA. Patients were grouped by the presence (n = 28) or absence (n = 84) of concomitant IHI and rTEG parameters, fibrinolytic phenotypes, SDC-1, and clinical outcomes were compared. Of the 112 thermally injured patients, 28 (25%) had IHI. Most patients were male (68.8%) with a median age of 40 (interquartile range, 29-57) years. Patients with IHI had higher overall mortality (42.68% vs 8.3%; P < .0001). rTEG LY30 was lower in patients with IHI at hours 4 and 12 (P < .05). There was a pattern of increased abnormal fibrinolytic phenotypes among IHI patients. There was a greater proportion of IHI patients with endotheliopathy (SDC-1 > 34 ng/ml) (64.7% vs 26.4%; P = .008). There was a pattern of increased mortality among patients with IHI and endotheliopathy (0% vs 72.7%; P = .004). Significant differences between patients with and without IHI were found in measures assessing fibrinolytic potential and endotheliopathy. Mortality was associated with abnormal fibrinolysis, endotheliopathy, and IHI. However, the extent to which IHI-associated dysfunction is independent of TBSA burn size remains to be elucidated.

Published
2022

6. Comparison of Rapid-, Kaolin-, and Native-TEG Parameters in Burn Patient Cohorts With Acute Burn-induced Coagulopathy and Abnormal Fibrinolytic Function

Author

Keyloun, John W, Le, Tuan D, Moffatt, Lauren T, Orfeo, Thomas, McLawhorn, Melissa M, Bravo, Maria-Cristina, Tejiram, Shawn, Bravo, Maria-Cristina, Brummel-Ziedins, Kathleen E, Callcut, Rachael A, Cohen, Mitchell J, Freeman, Kalev, Gautam, Aarti, Hammamieh, Rasha, Jett, Marti, McLawhorn, Melissa M, Moffatt, Lauren T, Petzold, Linda R, Pusateri, Anthony E, Shupp, Jeffrey W, Varner, Jeffrey D, Shupp, Jeffrey W, and Pusateri, Anthony E

Published
2024
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17. Endothelial dysfunction is dampened by early administration of fresh frozen plasma in a rodent burn shock model

Author

Kelly, Edward J., Ziedins, Eriks E., Carney, Bonnie C., Moffatt, Lauren T., and Shupp, Jeffrey W.

Abstract

Endothelial dysfunction has been implicated in the pathogenesis of shock. Fresh frozen plasma is a promising potential therapy. This work utilizes a rodent burn shock model to examine the timing of FFP administration and its effects on glycocalyx and cytokine transcription.

Published
2024
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24. Laser‐assisted drug delivery of synthetic alpha melanocyte stimulating hormone and L‐tyrosine leads to increased pigmentation area and expression of melanogenesis genes in a porcine hypertrophic scar model

Author

Carney, Bonnie C., primary, Oliver, Mary A., additional, Kurup, Sanjana, additional, Collins, Monica, additional, Keyloun, John W., additional, Moffatt, Lauren T., additional, Shupp, Jeffrey W., additional, and Travis, Taryn E., additional

Published
2023
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27. Evaluation of healing outcomes combining a novel polymer formulation with autologous skin cell suspension to treat deep partial and full thickness wounds in a porcine model: a pilot study

Author

Carney, Bonnie C., primary, Oliver, Mary A., additional, Erdi, Metecan, additional, Kirkpatrick, Liam D., additional, Tranchina, Stephen P., additional, Rozyyev, Selim, additional, Keyloun, John W., additional, Saruwatari, Michele S., additional, Daristotle, John L., additional, Moffatt, Lauren T., additional, Kofinas, Peter, additional, Sandler, Anthony D., additional, and Shupp, Jeffrey W., additional

Published
2022
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30. Comparison of Transcriptional Signatures of Three Staphylococcal Superantigenic Toxins in Human Melanocytes

Author

Chakraborty, Nabarun, primary, Srinivasan, Seshamalini, additional, Yang, Ruoting, additional, Miller, Stacy-Ann, additional, Gautam, Aarti, additional, Detwiler, Leanne J., additional, Carney, Bonnie C., additional, Alkhalil, Abdulnaser, additional, Moffatt, Lauren T., additional, Jett, Marti, additional, Shupp, Jeffrey W., additional, and Hammamieh, Rasha, additional

Published
2022
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31. Assessing Factor V Antigen and Degradation Products in Burn and Trauma Patients

Author

Keyloun, John W., primary, Le, Tuan D., additional, Orfeo, Thomas, additional, Brummel-Ziedins, Kathleen E., additional, Bravo, Maria C., additional, Kaye, Matthew D., additional, Bourne, Dana E., additional, Carney, Bonnie C., additional, Freeman, Kalev, additional, Mann, Kenneth G., additional, Pusateri, Anthony E., additional, Shupp, Jeffrey W., additional, McLawhorn, Melissa M., additional, Moffatt, Lauren T., additional, Callcut, Rachael A., additional, Cohen, Mitchell J., additional, Petzold, Linda R., additional, Varner, Jeffrey D., additional, Bravo, Maria Cristina, additional, Gautam, Aarti, additional, Hammamieh, Rasha, additional, and Jett, Marti, additional

Published
2022
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46. Proceedings of the 2021 American Burn Association State and Future of Burn Science Meeting.

Author

Group, The 2021 American Burn Association State and Future of Burn Science Working, Moffatt, Lauren T, and 2021 American Burn Association State and Future of Burn Science Working Group

Subjects
BURNS & scalds
Abstract

Periodically, the American Burn Association (ABA) has convened a State of the Science meeting on various topics representing multiple disciplines within burn care and research. In 2021 at the request of the ABA President, meeting development was guided by the ABA's Burn Science Advisory Panel (BSAP) and a subgroup of meeting chairs. The goal of the meeting was to produce both an evaluation of the current literature and ongoing studies, and to produce a research agenda and/or define subject matter-relevant next steps to advance the field(s). Members of the BSAP defined the topics to be addressed and subsequently solicited for nominations of expert speakers and topic leaders from the ABA's Research Committee. Current background literature for each topic was compiled by the meeting chairs and the library then enhanced by the invited topic and breakout discussion leaders. The meeting was held in New Orleans, LA on November 2nd and 3rd and was formatted to allow for 12 different topics, each with two subtopics, to be addressed. Topic leaders provided a brief overview of each topic to approximately 100 attendees, followed by expert-lead breakout sessions for each topic that allowed for focused discussion among subject matter experts and interested participants. The breakout and topic group leaders worked with the participants to determine research needs and associated next steps including white papers, reviews and in some cases collaborative grant proposals. Here, summaries from each topic area will be presented to highlight the main foci of discussion and associated conclusions. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Early Transcriptomic Response to Burn Injury: Severe Burns Are Associated With Immune Pathway Shutdown.

Author

Keyloun, John W, Campbell, Ross, Carney, Bonnie C, Yang, Ruoting, Miller, Stacy-Ann, Detwiler, Leanne, Gautam, Aarti, Moffatt, Lauren T, Hammamieh, Rasha, Jett, Marti, Shupp, Jeffrey W, group, SYSCOT study, and SYSCOT study group

Subjects
BURN patients, BURNS & scalds, INFLAMMATION, RNA, SEVERITY of illness index, GENE expression profiling, IMMUNITY, BIOCHIPS, DESCRIPTIVE statistics, LONGITUDINAL method
Abstract

Burn injury induces a systemic hyperinflammatory response with detrimental side effects. Studies have described the biochemical changes induced by severe burns, but the transcriptome response is not well characterized. The goal of this work is to characterize the blood transcriptome after burn injury. Burn patients presenting to a regional center between 2012 and 2017 were prospectively enrolled. Blood was collected on admission and at predetermined time points (hours 2, 4, 8, 12, and 24). RNA was isolated and transcript levels were measured with a gene expression microarray. To identify differentially regulated genes (false-discovery rate ≤0.1) by burn injury severity, patients were grouped by TBSA above or below 20% and statistically enriched pathways were identified. Sixty-eight patients were analyzed, most patients were male with a median age of 41 (interquartile range, 30.5-58.5) years, and TBSA of 20% (11%-34%). Thirty-five patients had % TBSA injury ≥20%, and this group experienced greater mortality (26% vs 3%, P = .008). Comparative analysis of genes from patients with

Published
2022
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50. Review of the Terminology Describing Ionizing Radiation-Induced Skin Injury: A Case for Standardization.

Author

Burnett, Luke R., Hughes, Ryan T., Rejeski, Alexis F., Moffatt, Lauren T., Shupp, Jeffrey W., Christy, Robert J., and Winkfield, Karen M.

Subjects
SKIN injuries, RADIODERMATITIS, RADIATION injuries, MEDICAL personnel, WOUND care, SKIN
Abstract

Ionizing radiation causes injury to the skin that produces a complex clinical presentation that is managed by various paradigms without clear standards. The situation is further complicated by the fact that clinicians and researchers often use different terms and billing codes to describe the spectrum of cutaneous injury. There is, however, general agreement between the two most commonly-used diagnostic scales, the Radiation Therapy Oncology Group and the Common Terminology Criteria for Adverse Events, and in their use to describe skin injury following radiation therapy. These scales are typically used by radiation oncologists to quantify radiation dermatitis, a component of the radiation-related disorders of the skin and subcutaneous tissue family of diagnoses. In rare cases, patients with severe injury may require treatment by wound care or burn specialists, in which case the disease is described as a "radiation burn" and coded as a burn or corrosion. Further compounding the issue, most US government agencies use the term Cutaneous Radiation Injury to indicate skin damage resulting from large, whole-body exposures. In contrast, the US Food and Drug Administration approves products for radiation dermatitis or "burns caused by radiation oncology procedures." A review of the literature and comparison of clinical presentations shows that each of these terms represents a similar injury, and can be used interchangeably. Herein we provide a comparative review of the commonly used terminology for radiation-induced skin injury. Further, we recommend standardization across clinicians, providers, and researchers involved in the diagnosis, care, and investigation of radiation-induced skin injury. This will facilitate collaboration and broader inclusion criteria for grant-research and clinical trials and will assist in assessing therapeutic options particularly relevant to patient skin pigmentation response differences. [ABSTRACT FROM AUTHOR]

Published
2021
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