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Interest in the phase behavior of hydrocarbons in shale reservoirs has grown in recent years. Petroleum fluid phase behavior has been observed to differ significantly between conventional reservoirs and shale reservoirs. Within shale reservoirs, notable surface-fluid interactions can lead to non-uniform molecule distribution and an alteration in fluid phase behavior, primarily caused by the existence of nano-scale porous materials. In this work, we study the phase behavior of methane in single cylindrical pore models. We apply the gauge Gibbs ensemble Monte Carlo (gauge-GEMC) simulation technique to investigate the phase behavior of methane in 4–10 nm single nanopores and calculate the saturation pressures at various temperatures using the grand canonical Monte Carlo (GCMC) simulation technique. A shift in the phase diagram has been found for methane in nanopores. As pore size decreases, the shift becomes more significant.

With the development of the petroleum industry and advancements in technology, gas injection techniques have gradually matured and become an important means to enhance oil recovery in reservoir development. Gas channeling is a major challenge in the process of gas injection development. The presence of gas channeling can lead to a decrease in the swept volume of gas flooding, severely affecting the effectiveness of gas injection development. This paper focuses on low-permeability reservoirs, comprehensively analyzing the development characteristics of low-permeability reservoirs and the dynamic characteristics of gas flooding production. It selects and evaluates indicators for assessing the development degree of gas channeling and establishes a fuzzy comprehensive evaluation method for evaluating gas channeling in the gas injection development of low-permeability reservoirs. Based on the evaluation values derived from the fuzzy comprehensive evaluation, it classifies the development levels of gas channeling. Application in oilfield cases shows that the evaluation results of this method are generally consistent with the dynamic response of production data, with high evaluation accuracy. This provides strong support for implementing gas channeling prevention and control measures on site and improving the effectiveness of gas injection development.

Abstract HIV subtypes convey important epidemiological information and possibly influence the rate of disease progression. In this study, HIV disease progression in patients infected with CRF01_AE, CRF07_BC, and subtype B was compared in the largest HIV molecular epidemiology study ever done in China. A national data set of HIV pol sequences was assembled by pooling sequences from public databases and the Beijing HIV laboratory network. Logistic regression was used to assess factors associated with the risk of AIDS at diagnosis ([AIDSAD], defined as a CD4 count

As efficient technologies boost oil yields and economic benefits, horizontal wells and hydraulic fracturing are widely used in low- permeability reservoirs. To better evaluate the reserve and improve recovery, it is essential to determine fluid flow patterns and transport mechanisms. Laboratory experiments, field operations, and analytical studies have identified nonlinear flow and microfracture networks during the fluid flow in a reservoir with fractured horizontal wells. However, the interactions between nonlinear flow and microfracture networks are still not fully understood. In this study, nonlinear flow experiments and triaxial compression tests were carried out to analyze nonlinear flow characteristics in the vicinity of microfracture networks. By analyzing the effects of microfracture networks on nonlinear flow, two-phase flow, rock stress sensitivity, and artificial fractures, we found that fluid capacity in capillaries with smaller dimensions decreased along with a drop in the pressure gradient, generating a nonlinear flow pattern. The area of nonlinear flow was diminished by the presence of microfractures, which improved flow efficiency and reservoir quality. Considering the size of fracture apertures, microfractures behave more like matrix pores than natural fractures. Also, microfractures significantly increase rock stress sensitivity and reduce the threshold permeability, which enhances fluid flow capacity. This study contributes to our understanding of flow behavior, predicting production and improving recovery in low-permeability reservoirs.

The study on the flow behaviors of oil and water two phases in porous media and their influencing factor is very important to adjust the porous carbonate reservoir development strategy and enhance the oil recovery. Based on the CT (computed tomography) scanning of real carbonate reservoir core sample, the micropore structure was reconstructed, and the effects of different factors (injection rate, oil-to-water viscosity ratio, and contact angle) and secondary development methods (higher injection rate and water displacement direction optimization) on the flow behavior of oil and water two phases were explored by numerical simulation in this paper. It is found from the study that the pores in the porous carbonate reservoirs have good structural connectivity. During the displacement process, the oil-water interface mainly resides at the pore throat junction with a large change of pore size, and the Haines jumps exist in the oil-water movement; the areal sweep efficiency of the water phase is jointly affected by the viscosity effect, interfacial tension, pore structure, and injection rate. Under the minimum injection rate and oil-to-water viscosity ratio, the maximum oil recovery can be obtained, and the oil recovery is 52.62% and 57.01%, respectively. The recovery efficiency and swept area are better in a water-wet system than oil-wet system. During the secondary development, the remaining oil is hardly displaced even with the injection rate increased by a factor of 50, and it shows improvement after 250 times of initial injection rate. Changing the position of water inlet and the produced fluid outlet results in better recovery since the remaining oil near the new inlet and outlet can be effectively produced.