76 results on '"Min-Ji Kang"'
Search Results
2. Molecular Design of Encapsulin Protein Nanoparticles to Display Rotavirus Antigens for Enhancing Immunogenicity
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Hyun-Gyo Jung, Seonghun Jeong, Min-Ji Kang, Ingi Hong, Young-Shin Park, Eunbyeol Ko, Jae-Ouk Kim, and Deog-Young Choi
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encapsulin ,nanoparticle ,rotavirus ,vaccine ,VP8 ,immunization ,Medicine - Abstract
Rotavirus considerably threatens global health, particularly for children
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- 2024
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3. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model
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Jung-Eun Park, Jiyoun Lee, Soonhyuck Ok, Seunghee Byun, Eun-Ju Chang, Sung-Eun Yoon, Young-Joon Kim, and Min-Ji Kang
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Medicine ,Biochemistry ,QD415-436 - Abstract
Abstract The endoplasmic reticulum (ER) is a subcellular organelle essential for cellular homeostasis. Perturbation of ER functions due to various conditions can induce apoptosis. Chronic ER stress has been implicated in a wide range of diseases, including autosomal dominant retinitis pigmentosa (ADRP), which is characterized by age-dependent retinal degeneration caused by mutant rhodopsin alleles. However, the signaling pathways that mediate apoptosis in response to ER stress remain poorly understood. In this study, we performed an unbiased in vivo RNAi screen with a Drosophila ADRP model and found that Wg/Wnt1 mediated apoptosis. Subsequent transcriptome analysis revealed that ER stress-associated serine protease (Erasp), which has been predicted to show serine-type endopeptidase activity, was a downstream target of Wg/Wnt1 during ER stress. Furthermore, knocking down Erasp via RNAi suppressed apoptosis induced by mutant rhodopsin-1 (Rh-1P37H) toxicity, alleviating retinal degeneration in the Drosophila ADRP model. In contrast, overexpression of Erasp resulted in enhanced caspase activity in Drosophila S2 cells treated with apoptotic inducers and the stabilization of the initiator caspase Dronc (Death regulator Nedd2-like caspase) by stimulating DIAP1 (Drosophila inhibitor of apoptosis protein 1) degradation. These findings helped identify a novel cell death signaling pathway involved in retinal degeneration in an autosomal dominant retinitis pigmentosa model.
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- 2023
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4. Temporary Myopic Shift in a Patient with Multiple Parallel-Line Endotheliitis
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Jee Hye Lee, Yongsun Ahn, Ji Min Park, Jehyung Hwang, and Min-Ji Kang
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multiple parallel-line endotheliitis ,myopic shift ,endotheliitis ,corneal endothelium ,keratic precipitates ,Ophthalmology ,RE1-994 - Abstract
Here, we report the case of a patient with multiple parallel-line endotheliitis with myopic shift, which has not been previously reported. A 36-year-old man visited our clinic with blurred vision in his left eye. A slit lamp examination revealed an interesting pattern of multiple parallel lines of keratic precipitates, along with subtle corneal edema. The spherical equivalents measured in the right and left eyes were −9.25 and −11.875 diopter, respectively, with the left eye showing more myopic progression. On specular microscopy, endothelial cell loss was found in the left eye. After administration of a weak topical steroid, keratic precipitates and corneal edema resolved completely within 2 days. The myopic shift in his left eye recovered to −10.0 diopters. Multiple parallel-line endotheliitis can be easily treated with a weak topical steroid in a short period. A temporary myopic shift may occur, which in this case resolved upon disease recovery. However, corneal endothelial cell loss is inevitable; therefore, careful monitoring is needed.
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- 2023
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5. Physiological and biochemical responses of Limonium tetragonum to NaCl concentrations in hydroponic solution
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Seong-Nam Jang, Min-Ji Kang, Yun Na Kim, Eun Ju Jeong, Kye Man Cho, Jae Gil Yun, and Ki-Ho Son
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halophyte ,Limonium tetragonum ,salt stress ,myricetin ,hydroponics ,Plant culture ,SB1-1110 - Abstract
IntroductionLimonium (L.) tetragonum (Thunb.) A. A. Bullock, a halophyte that grows all over the southwest coast of Korea, is a medicinal plant with various pharmacological effects. The salt defense mechanism stimulates the biosynthesis of various secondary metabolites and improves functional substances. In this study, we investigated the optimal NaCl concentration for the growth and enhancement of secondary metabolites in hydroponically grown L. tetragonum.MethodsThe seedlings grown for 3 weeks in a hydroponic cultivation system were treated with 0-, 25-, 50-, 75-, and 100-mM NaCl in Hoagland’s nutrient solution for 8 weeks. No significant effect on the growth and chlorophyll fluorescence was observed for the NaCl concentrations below 100-mM.Results and discussionsThe increase in the NaCl concentration resulted in the decrease in the water potential of the L. tetragonum leaves. The Na+ content accumulated in the aerial part increased rapidly and the content of K+, which acts as an antagonist, decreased with the increase in NaCl concentrations in hydroponics. The total amino acid content of L. tetragonum decreased compared to the 0-mM NaCl, and most of the amino acid content decreased as the NaCl concentration increased. In contrast, the content of urea, proline (Pro), β-alanine, ornithine, and arginine was increased with an increase in NaCl concentration. The Pro content at 100-mM NaCl accounted for 60% of the total amino acids and was found to be a major osmoregulator as an important component of the salt defense mechanisms. The top five compounds identified in the L. tetragonum were classified as flavonoids while the flavanone compound was detected only in the NaCl treatments. A total of four myricetin glycosides were increased in comparison to the 0-mM NaCl. Among the differentially expressed genes, a significantly large change in Gene ontology was seen in the circadian rhythm. NaCl treatment enhanced the flavonoid-based substances of L. tetragonum. The optimum NaCl concentration for the enhancement of secondary metabolites of the L. tetragonum in the vertical farm-hydroponic cultivation system was 75-mM NaCl.
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- 2023
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6. ATF4 Responds to Metabolic Stress in Drosophila
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Soonhyuck Ok, Jung-Eun Park, Seunghee Byun, Kwonyoon Kang, Jaekyoung Son, and Min-Ji Kang
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atf4 ,integrated stress response ,nutrient restriction ,lipase ,microarray ,drosophila ,Biochemistry ,QD415-436 ,Biology (General) ,QH301-705.5 - Abstract
Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response. ATF4 regulates adaptive gene expression, thereby triggering stress resistance in cells. Methods: To characterize the metabolic status of atf4-/- Drosophila larvae, we conducted both metabolomic and microarray analyses. Results: Metabolomic analysis demonstrated an increase in lactate levels in atf4-/- mutants when compared to wild-type flies. However, there was a significant reduction in adenosine triphosphate (ATP) synthesis in the atf4-/- flies, suggesting an abnormal energy metabolism in the mutant larvae. Microarray analysis unveiled that Drosophila ATF4 controls gene expression related to diverse biological processes, including lipase activity, oxidoreductase activity, acyltransferase, immune response, cell death, and transcription factor, particularly under nutrient-restricted conditions. In situ hybridization analysis further demonstrated specific augmentation of CG6283, classified as a gastric lipase, within the gastric caeca of nutrient-restricted flies. Moreover, overexpression of lipases, CG6283 and CG6295, made the flies resistant to starvation. Conclusions: These findings underscore the role of Drosophila ATF4 in responding to metabolic fluctuations and modulating gene expression associated with metabolism and stress adaptation. Dysregulation of ATF4 may detrimentally impact the development and physiology of Drosophila.
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- 2023
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7. Raloxifene induced keratopathy: A case report
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Ji Min Park, Kyeong Do Jeong, Min-Ji Kang, Jee Hye Lee, Jae Suk Kim, and Je Hyung Hwang
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Drug-induced keratopathy ,Keratopathy ,Raloxifene ,Selective estrogen receptor modulator ,Ophthalmology ,RE1-994 - Abstract
Purpose: We report a case of corneal verticillata in a patient who had been taking raloxifene for a prolonged period. To our knowledge, this is the first case report of an ocular side effect of raloxifene. Observations: A 69-year-old female patient presented to our clinic for her routine eye check-up. On slit-lamp examination, whorl-like subepithelial deposits were observed in the bilateral corneas. She was diagnosed with corneal verticillata (vortex keratopathy) caused by raloxifene. A follow-up evaluation was conducted after discontinuation of the drug; however, the corneal opacity did not improve. Conclusions and importance: Patients with corneal verticillata should be asked regarding any intake of raloxifene for osteoporosis, as it may cause corneal verticillata.
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- 2022
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8. Progress in Nano-Biosensors for Non-Invasive Monitoring of Stem Cell Differentiation
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Min-Ji Kang, Yeon-Woo Cho, and Tae-Hyung Kim
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stem cell differentiation ,biosensing ,nano- and micromaterials ,Biotechnology ,TP248.13-248.65 - Abstract
Non-invasive, non-destructive, and label-free sensing techniques are required to monitor real-time stem cell differentiation. However, conventional analysis methods, such as immunocytochemistry, polymerase chain reaction, and Western blot, involve invasive processes and are complicated and time-consuming. Unlike traditional cellular sensing methods, electrochemical and optical sensing techniques allow non-invasive qualitative identification of cellular phenotypes and quantitative analysis of stem cell differentiation. In addition, various nano- and micromaterials with cell-friendly properties can greatly improve the performance of existing sensors. This review focuses on nano- and micromaterials that have been reported to improve sensing capabilities, including sensitivity and selectivity, of biosensors towards target analytes associated with specific stem cell differentiation. The information presented aims to motivate further research into nano-and micromaterials with advantageous properties for developing or improving existing nano-biosensors to achieve the practical evaluation of stem cell differentiation and efficient stem cell-based therapies.
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- 2023
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9. The Correlation between Matrix Metalloproteinase-9 Point-of-Care Immunoassay, Tear Film Osmolarity, and Ocular Surface Parameters
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Min-Ji Kang, Hyun Seung Kim, Man Soo Kim, and Eun Chul Kim
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Ophthalmology ,RE1-994 - Abstract
Background. Dry eye disease is a multifactorial disease that is difficult to diagnose due to multiple causative factors. The study aimed to evaluate the correlations between tear film matrix metalloproteinase-9 (MMP-9), tear film osmolarity, and ocular surface parameters in patients with dry eyes. Methods. We performed a retrospective chart review for patients diagnosed with dry eye and investigated if associations existed amongst noninvasive tear breakup time (NIBUT); corneal staining scores; and MMP-9 grade, tear film osmolarity, and Schirmer’s test I results. Results. Twenty-four eyes of 24 patients were enrolled in the current study. The grade of MMP-9 (0–4) was positively correlated with tear film osmolarity (p=0.027). However, neither qualitative (positive or negative) nor quantitative (grade 0–4) measurements of MMP-9 correlated with any other ocular surface parameters. The osmolarity in the positive corneal staining group was significantly higher than that in the negative group (321.6 ± 19.261 and 299.89 ± 16.213, respectively; p=0.018). None of the other ocular surface parameters were correlated with tear film osmolarity. Conclusion. Tear film MMP-9 may be an indicator for tear film osmolarity, or vice-versa. Moreover, osmolarity may have a correlation with corneal staining in patients with dry eye. Tear film MMP-9 and osmolarity tests can be helpful and convenient evaluation tools for identifying inflammation in dry eye disease in clinical practice.
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- 2022
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10. Reduction of Ethyl Carbamate in an Alcoholic Beverage by CRISPR/Cas9-Based Genome Editing of the Wild Yeast
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Jin-Young Jung, Min-Ji Kang, Hye-Seon Hwang, Kwang-Rim Baek, and Seung-Oh Seo
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ethyl carbamate ,alcoholic beverages ,Saccharomyces cerevisiae ,CRISPR/Cas9 ,genome editing ,Chemical technology ,TP1-1185 - Abstract
Ethyl carbamate (EC) is a naturally occurring substance in alcoholic beverages from the reaction of ethanol with urea during fermentation and storage. EC can cause dizziness and vomiting when consumed in small quantities and develop kidney cancer when consumed in excess. Thus, the reduction of EC formation in alcoholic beverages is important for food safety and human health. One of the strategies for reducing EC contents in alcoholic beverages is developing a new yeast starter strain to enable less formation of EC during fermentation. In this study, we isolated a polyploid wild-type yeast Saccharomyces cerevisiae strain from the Nuruk (Korean traditional grain-based inoculum of wild yeast and mold) and developed a starter culture by genome engineering to reduce EC contents in alcoholic beverages. We deleted multiple copies of the target genes involved in the EC formation in the S. cerevisiae by a CRISPR/Cas9-based genome editing tool. First, the CAR1 gene encoding for the arginase enzyme responsible for the formation of urea was completely deleted in the genome of S. cerevisiae. Additionally, the GZF3 gene encoding the transcription factor controlling expression levels of several genes (DUR1, 2, and DUR3) related to urea absorption and degradation was deleted in S. cerevisiae to further reduce the EC formation. The effects of gene deletion were validated by RT-qPCR to confirm changes in transcriptional levels of the EC-related genes. The resulting strain of S. cerevisiae carrying a double deletion of CAR1 and GZF3 genes successfully reduced the EC contents in the fermentation medium without significant changes in alcohol contents and fermentation profiles when compared to the wild-type strain. Finally, we brewed the Korean traditional rice wine Makgeolli using the double deletion strain of S. cerevisiae dCAR1&GZF3, resulting in a significant reduction of the EC content in Makgeolli up to 41.6% when compared to the wild-type strain. This study successfully demonstrated the development of a starter culture to reduce the EC formation in an alcoholic beverage by CRISPR/Cas9 genome editing of the wild yeast.
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- 2022
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11. Safety Evaluation by Phenotypic and Genomic Characterization of Four Lactobacilli Strains with Probiotic Properties
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Ye-Rim Lee, Won Yeong Bang, Kwang-Rim Baek, Geun-Hyung Kim, Min-Ji Kang, Jungwoo Yang, and Seung-Oh Seo
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Lactobacilli ,Lactobacillus fermentum ,Lactobacillus gasseri ,Lactobacillus helveticus ,Lactobacillus salivarius ,probiotics ,Biology (General) ,QH301-705.5 - Abstract
Probiotic Lactobacillus species are known to exert health benefits in hosts when administered in adequate quantities. A systematic safety assessment of the strains must be performed before the Lactobacillus strains can be designated as probiotics for human consumption. In this study, we selected Lactobacillus fermentum IDCC 3901, L. gasseri IDCC 3101, L. helveticus IDCC 3801, and L. salivarius IDCC 3551 as representative Lactobacilli probiotic strains and investigated their probiotic properties and potential risks through phenotypic and genomic characterization. Various assays including antimicrobial resistance, biogenic amine production, L-/D-lactate production, acute oral toxicity, and antipathogenic effect were performed to evaluate the safety of the four Lactobacillus strains. Genomic analysis using whole genome sequencing was performed to investigate virulence and antibiotic resistance genes in the genomes of the selected probiotic strains. The phenotypes of the strains such as enzymatic activity and carbohydrate utilization were also investigated. As a result, antibiotic resistances of the four Lactobacillus species were detected; however, neither antibiotic resistance-related genes nor virulence genes were found by genomic analysis. Moreover, the four Lactobacillus species did not exhibit hemolytic activity or β-glucuronidase activity. The biogenic amine production and oral acute toxicity were not shown in the four Lactobacillus species, whereas they produced D-lactate with minor ratio. The four Lactobacillus species exhibited antipathogenic effect to five pathogenic microorganisms. This study provides a way to assess the potential risks of four different Lactobacillus species and validates the safety of all four strains as probiotics for human consumption.
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- 2022
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12. Microbial Contamination of Preservative-Free Artificial Tears Based on Instillation Techniques
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Jee-Hye Lee, Min-Ji Kang, Ha-Eun Sim, and Je-Hyung Hwang
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preservative-free artificial tears ,contamination ,eye drop instillation technique ,Medicine - Abstract
Preservative-free artificial tears eliminate the side effects of preservatives but are prone to microbial contamination. This study evaluates the incidence of microbial contaminations in single-use vials of preservative-free 0.1% hyaluronate artificial tears. Based on what touched the vial tip during its first use, 60 unit-dose vials (0.5 mL) were divided into groups A (no touch, n = 20), B (fingertip, n = 20), and C (lid margin, n = 20). The vials were recapped after the first use, and the residual solution was cultured 24 h later. The solution from 20 aseptically opened and unused vials was also cultured (group D). Microbial contamination rates were compared between the groups using the Fisher’s exact test. Groups B and C contained 45% (9/20) and 10% (2/20) contaminations while groups A and D contained undetected microbial growth. The culture positivity rates were significantly different between groups A and B (p = 0.001) and groups B and C (p = 0.013) but not between groups A and C (p = 0.487). We demonstrate a significantly higher risk of contamination when fingertips touch the vial mouth. Therefore, users should avoid the vial tip touching the fingers or eyelid during instillation to prevent contamination of the eye drops.
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- 2022
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13. Production of Vitamin K by Wild-Type and Engineered Microorganisms
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Min-Ji Kang, Kwang-Rim Baek, Ye-Rim Lee, Geun-Hyung Kim, and Seung-Oh Seo
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vitamin K ,production ,microorganisms ,fermentation ,metabolic engineering ,Biology (General) ,QH301-705.5 - Abstract
Vitamin K is a fat-soluble vitamin that mainly exists as phylloquinone or menaquinone in nature. Vitamin K plays an important role in blood clotting and bone health in humans. For use as a nutraceutical, vitamin K is produced by natural extraction, chemical synthesis, and microbial fermentation. Natural extraction and chemical synthesis methods for vitamin K production have limitations, such as low yield of products and environmental concerns. Microbial fermentation is a more sustainable process for industrial production of natural vitamin K than two other methods. Recent advanced genetic technology facilitates industrial production of vitamin K by increasing the yield and productivity of microbial host strains. This review covers (i) general information about vitamin K and microbial host, (ii) current titers of vitamin K produced by wild-type microorganisms, and (iii) vitamin K production by engineered microorganisms, including the details of strain engineering strategies. Finally, current limitations and future directions for microbial production of vitamin K are also discussed.
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- 2022
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14. Road Geometry Safety Evaluation Based on Driver Behavior Using a Driving Simulator.
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Min Ji Kang, Hyun Su Park, Oh Hoon Kwon, and Shin Hyoung Park
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- 2023
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15. DRSPRING: Graph convolutional network (GCN)-Based drug synergy prediction utilizing drug-induced gene expression profile.
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Jiyeon Han, Min Ji Kang, and Sanghyuk Lee
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- 2024
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16. Artificial Intelligence-Based Anomaly Detection Technology over Encrypted Traffic: A Systematic Literature Review.
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Ilhwan Ji, Ju Hyeon Lee, Min Ji Kang, Woo Jin Park, Seungho Jeon, and Jung-Taek Seo
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- 2024
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17. Retraction Note to: Analysis of risk factors related to the re-fracture of adjacent vertebral body after PKP
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Fang, Shen-Yun, Dai, Ji-Lin, Min, Ji-Kang, and Zhang, Wei-Li
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- 2022
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18. RETRACTED ARTICLE: Analysis of risk factors related to the re-fracture of adjacent vertebral body after PKP
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Fang, Shen-Yun, Dai, Ji-Lin, Min, Ji-Kang, and Zhang, Wei-Li
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- 2021
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19. Oblique lateral interbody fusion combined with lateral plate fixation for the treatment of degenerative diseases of the lumbar spine: A retrospective study
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Li, Hai-Dong, Zhong, Li, Min, Ji-Kang, Fang, Xiang-Qian, and Jiang, Lei-Sheng
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- 2022
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20. Conservation Treatment of the Printing Woodblocks with Inscription of 'Hunmongjahoe' in the Collection of the Pusan National University Museum
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Sang Yoon Jo, Jung Hae Park, Young Mok Kim, Min Ji Kang, and Soo Chul Kim
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General Medicine - Abstract
Printing woodblocks with inscription of “Hunmongjahoe”, in the collection of the Pusan National University Museum, is engraved the “Hunmongjahoe” written by Se-jin Choi who is a translator at the reign of King Joongjong of the Joseon Dynasty on the woodblocks, and it is consists of totally 52 pieces of ‘In’, ‘Sang’, ‘Jung’ and ‘Ha’. A conservation treatment was performed because a number of damage to the woody part due to insect damage was confirmed on above woodblocks. A number of traces presumed as the insect holes generated by harmful insects were observed on the surface and inside of the woodblocks as a result of X-ray inspection to determine the approximate size of damage by insects prior to the conservation treatment. In addition, all 52 pieces were identified as Acer spp. as a result of species identification to confirm the tree species used in the woodblocks production. 3D Scan was conducted for digital recording and precise measurement of Printing woodblocks with inscription of “Hunmongjahoe” after the pre-treatment survey and analysis, and it was possible to produce various size-specific end pieces as a result of it. The conservation treatment of woodblocks were performed in the order of cleaning, consolidation treatment, edge of a woodblocks manufacturing and assembly, and it was possible to stably preserve and treat woody part which were degraded and peeled off due to the insects as a result of applying above conservation treatment method.
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- 2023
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21. Universal Polymeric Hole Transporting Material for Solution-Processable Green and Blue Thermally Activated Delayed Fluorescence OLEDs
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Hyeondoo Je, Min Ju Cho, Na Yeon Kwon, Su Hong Park, Min Ji Kang, Heume Il Baek, Junho Youn, Chang Wook Han, and Dong Hoon Choi
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General Materials Science - Published
- 2023
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22. Rational strategy to enhance the thermal stability of solar cell performance using a photocrosslinkable conjugated polymer
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Hong Diem Chau, Su Hong Park, Sung Hoon Jung, Jin Young Park, Min Ji Kang, Amit Kumar Harit, Han Young Woo, Min Ju Cho, and Dong Hoon Choi
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Renewable Energy, Sustainability and the Environment ,General Materials Science ,General Chemistry - Abstract
A photocrosslinkable donor, PM6-X30, has been designed by engineering the side chains of the PM6 backbone. A high PCE of 12.33% was achieved with significantly enhanced thermal stability.
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- 2023
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23. Effects of surface hydroxyl ions on the color of sintered Al2O3 characterized by X-ray photoelectron and infrared spectroscopy
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Min Ji Kang and Dang-Hyok Yoon
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Materials Chemistry ,Ceramics and Composites - Published
- 2022
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24. Effect of Kümmell's disease with kyphosis on spinal-pelvic sagittal parameters.
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HE Shou-yu, MIN Ji-kang, LI Hai-dong, ZHANG Qiang-hua, and DAI Ji-lin
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- 2024
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25. Corneal Graft Rejection after Vaccination against COVID-19: A Case Report
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Ji Min Park, Jee Hye Lee, Je Hyung Hwang, and Min-Ji Kang
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Ophthalmology - Published
- 2023
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26. Exploring Real-Time Word Learning Skills and Its Related Factors in Preschool Children: An Eye-Tracking Study
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Yoonhee Yang, Dongsun Yim, Wonjeong Park, Soo Jung Baek, and Min Ji Kang
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Speech and Hearing ,Linguistics and Language ,Communication - Abstract
Objectives: This study aimed to identify the real-time word learning processing aspects of children in each group by classifying groups according to their actual vocabulary acquisition performance (offline processing data) in QUIL (Quick incidental learning). We compared whether there was a significant difference between the QUIL offline and online processing data of the two groups, and finally we attempted to explore whether QUIL offline and online processing data had a significant correlation with children’s working memory. Methods: Thirty-three children [21 with TD (Typically developing children); and 12 with SLI (Children with specific language impairment)] aged 3- to 6-year-old participated in this study. K-mean cluster analysis was conducted to create new groups based on QUIL offline scores, and to examine children’s online word learning processing. To analyze the children’s word learning process with an eye-tracker, the animations recorded with narration were shown to the children through a computer with an eye-tracker attached. Results: There was a significant difference between the two clusters at the third exposure condition in online data (fixation duration). In addition, there was a significant correlation between QUIL online processing and linguistic WM (Working memory) in cluster 1, and between QUIL offline scores and nonlinguistic WM in cluster 2. Conclusion: When new vocabulary is exposed for cluster 2, it can be inferred that the efficiency of vocabulary acquisition will be improved if visual information is intensively combined with language information.
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- 2022
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27. Establishment of a useful in vitro decidual induction model using eCG-primed nonpregnant mouse endometrial stromal cells
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Ji Eun, Kim, Min Young, Lee, Min-Ji, Kang, Jihyun, Byun, Jeong Bin, Jo, Hye-Yeong, Yang, Jong-Hoon, Kim, Kyung-Ah, Lee, and Yong-Pil, Cheon
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Gonadotropins, Equine ,Uterus ,Cell Biology ,General Medicine ,Mice ,Endometrium ,Reproductive Medicine ,Pregnancy ,Decidua ,Animals ,Female ,Horses ,Embryo Implantation ,Stromal Cells ,Progesterone - Abstract
Uterine endometrial differentiation is essential for developmental continuity and female health. A convenient in vitro model mimicking the physiological status is needed to effectively evaluate implantation and uterine response mechanisms. Thus, we developed a promising in vitro model, the FSS (FSH mimic-stimulated synchronized) model, by using primary mouse uterine stromal cells (mUSCs) obtained from equine chorionic gonadotropin (eCG)-primed mice. These mUSCs could be differentiated into decidualized cells with 17 beta-estradiol (E2) and progesterone (P4). The pregnancy day 4 (PD4) model, in which mUSCs are obtained at day 4 of pregnancy, was used as a control. The cell shape index and polyploidy rates were similar between the two models. The staining intensities of lipids and glycogen were significantly higher in the induced groups in both models but stronger in the FSS model than in the PD4 model. The expression levels of AP-TNAP, cathepsin L, Prl8a2, Gja1, Cebpb, and Igfbp1 were increased at 24 h after decidual induction. PR-alpha and PR-beta levels were also increased at 24 h after decidual induction in both models. These results indicate that the FSS model provides a convenient method for obtaining USCs that are usable for various experimental approaches due to their physiological competence and flexibility for triggering induction. This may serve as a model system for the study of pathogeneses originating from the endometrium or communication with other tissues and lead to a better understanding of embryo implantation mechanisms. Furthermore, the results of this study will be integral for further refinements of 3D uterine culture manipulation techniques.
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- 2022
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28. Rational Molecular Design Strategy for Host Materials in Thermally Activated Delayed Fluorescence-OLEDs Suitable for Solution Processing
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Na Yeon Kwon, Su Hong Park, Chang Woo Koh, Jin Young Park, Min Ji Kang, Heume Il Baek, Junho Youn, Sungnam Park, Chang Wook Han, Min Ju Cho, and Dong Hoon Choi
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General Materials Science - Published
- 2023
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29. Mobility Assistive Devices Use Status and Satisfaction Survey among Elderly with Brain Lesions Disability
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Min-Ji Kang
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- 2022
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30. Effects of impurities on the slip viscosity and sintered properties of low-soda easy-sintered α-alumina
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Min Ji Kang and Dang-Hyok Yoon
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Ceramics and Composites - Published
- 2022
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31. Raloxifene induced keratopathy: A case report
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Haeun Sim, Jeonga Jeong, Min Ji Kang, and Jehyung Hwang
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Ophthalmology ,General Medicine - Published
- 2022
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32. New onset of acute uveitis following <scp>COVID</scp> ‐19 vaccination
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Haeun Sim, Jeonga Jeong, Min Ji Kang, and Jehyung Hwang
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Ophthalmology ,General Medicine - Published
- 2022
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33. Hysterectomy for benign indication and risk of cataract in women in South Korea
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Haeun Sim, Jeonga Jeong, Min Ji Kang, and Jehyung Hwang
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Ophthalmology ,General Medicine - Published
- 2022
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34. Menopausal hormone therapy and the risk of cataract in postmenopausal women in South Korea
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Haeun Sim, Jeonga Jeong, Min Ji Kang, and Jehyung Hwang
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Ophthalmology ,General Medicine - Published
- 2022
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35. Strong inhibition of organic cation transporter 2 by flavonoids and attenuation effects on cisplatin-induced cytotoxicity
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Kwang-Hee Shin, Kyeong-Ryoon Lee, Min-Ji Kang, and Yoon-Jee Chae
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General Medicine ,Toxicology - Published
- 2023
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36. Corneal Graft Rejection after Vaccination against Coronavirus Disease
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Ji Min, Park, Jee Hye, Lee, Je Hyung, Hwang, and Min-Ji, Kang
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- 2022
37. Comprehensive Comparison of Chemical Composition and Antioxidant Activity of Panax ginseng Sprouts by Different Cultivation Systems in a Plant Factory
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Kye Man Cho, Hee Yul Lee, Du Yong Cho, Jea Gack Jung, Min Ju Kim, Jong Bin Jeong, Seong-Nam Jang, Ga Oun Lee, Han-Sol Sim, Min Ji Kang, Ye Lin Kim, Ji Hyun Lee, Sooyeon Lim, and Ki-Ho Son
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Ecology ,ginseng ,ginsenoside ,free amino acid ,medicinal plant ,vertical farm ,Plant Science ,Ecology, Evolution, Behavior and Systematics - Abstract
In this study, the primary (such as amino acids, fatty acids, and minerals) and secondary (including ginsenosides, phenolic acids, and flavonols) metabolites and antioxidant effects of Panax ginseng sprouts (PGSs) by different cultivation systems, such as soil–substrate cultivation (SSC) and deep-water cultivation (DWC), in a plant factory has been observed. There was no significant difference in the total fatty acid (FA) contents. Particularly, the major FAs of PGSs were palmitic acid (207.4 mg/100 g) of saturated FAs and linoleic acid (397.6 mg/100 g) and α-linolenic acid (222.6 mg/100 g) of unsaturated FAs in the SSC system. The values of total amino acids were all higher in SSC than in DWC. In the case of ginsenosides, the total protopanaxtriol product was 30.88 mg/g in SSC, while the total protopanaxdiol product was 34.83 mg/g in DWC. In particular, the values of total phenolic acids and total flavonols were 133.36 and 388.19 ug/g, respectively, and SSC had a higher content than DWC. In conclusion, the SSC system was shown to be higher in nutritional constituents and antioxidant activities in soil cultivation, suggesting that PGS with SSC has a positive effect on the quality of PGS in a plant factory.
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- 2022
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38. A high-performance liquid chromatography–evaporative light scattering detection–based quantitative analytical method for polyvinyl alcohol in food supplements with pyrolysis–gas chromatography/mass spectrometry-based verification
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Juhee Park, Jihee Lee, Young-Min Kim, Min ji Kang, Hee-Jae Suh, Jihyun Lee, Hee-Seok Lee, and Chan Lee
- Subjects
Applied Microbiology and Biotechnology ,Food Science ,Biotechnology ,Research Article - Abstract
Polyvinyl alcohol (PVOH) is extensively used in agricultural, pharmaceutical, textile, and food industries. A new high-performance liquid chromatography (HPLC) method with evaporative light scattering detection (ELSD) was developed for the quantitative analysis of PVOH products. Pyrolysis–gas chromatography/mass spectrometry (Py–GC/MS) was employed for method verification. The HPLC–ELSD method exhibited acceptable linearity (R(2) > 0.99), with limits of detection and quantitation of 19.43 and 58.88 μg/mL, respectively. Accuracies of 91.16–102.30% were estimated based on recoveries of the intra- and inter-day tests of PVOH. Repeatability and intermediate precision (%RSD) of 1.23–4.45 and 2.18–6.95, respectively, were obtained. The presence of PVOH in the HPLC peaks was further verified using typical indicators of PVOH in Py–GC/MS analysis, such as acetaldehyde, 2,5-dihydrofuran, benzaldehyde, and crotonaldehyde. This novel HPLC method with Py–GC/MS-based verification can be successfully applied for analyzing PVOH in dietary supplement tablets.
- Published
- 2022
39. Oblique lateral interbody fusion combined with lateral plate VS. combined with pedicle screw fixation for the treament of lumbar degenerative diseases
- Author
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Li, Hai-Dong, primary, Zhu, Xin-Hong, additional, Min, Ji-Kang, additional, and Zhong, Li, additional
- Published
- 2022
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- View/download PDF
40. Adipose tissue LECT2 expression is associated with obesity and insulin resistance in Korean women
- Author
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Jimin Kim, Seul Ki Lee, Donguk Kim, Eunyoung Lee, Chan Yoon Park, Han Choe, Min‐Ji Kang, Hwa Jung Kim, Jong‐Hyeok Kim, Joon Pio Hong, Yeon Ji Lee, Hye Soon Park, Yoonseok Heo, and Yeon Jin Jang
- Subjects
Nutrition and Dietetics ,Endocrinology ,Adipose Tissue ,Diabetes Mellitus, Type 2 ,Endocrinology, Diabetes and Metabolism ,Republic of Korea ,Medicine (miscellaneous) ,Humans ,Intercellular Signaling Peptides and Proteins ,Female ,Obesity ,Insulin Resistance - Abstract
Leukocyte cell-derived chemotaxin 2 (LECT2) is an obesity-upregulated hepatokine inducing skeletal muscle insulin resistance. The study's aim was to explore whether LECT2 is expressed in human adipose tissue and whether the expression is dysregulated during obesity and associated with obesity-related metabolic disorders.This study measured metabolic parameters, serum LECT2, and expression of LECT2 and CD209, a gene encoding a putative receptor for LECT2, in abdominal subcutaneous and visceral adipose tissues in women with obesity (with or without type 2 diabetes) and women with normal weight. The expression/secretion of LECT2 and its putative effects were assessed in human adipocytes.Adipose tissue LECT2 mRNA and serum LECT2 were higher in women with obesity and were significantly correlated with parameters related to insulin resistance. LECT2 was mainly expressed by adipocytes. Both LECT2 and CD209 expression was higher in adipocytes from women with obesity. Incubating adipocytes with substances mimicking the microenvironment of obesity adipose tissue increased LECT2 expression/secretion. LECT2 treatment of adipocytes suppressed insulin-stimulated Akt phosphorylation; it reduced adiponectin (ADIPOQ) and increased leptin (LEP) expression in a CD209-dependent manner.This study demonstrates that LECT2 expression in adipose tissue is high in patients with obesity and associated with insulin resistance and suggests that adipocyte-derived LECT2 may contribute to adipose tissue dysfunction.
- Published
- 2022
41. Serum vitamin D-binding protein (VDBP) concentration and rs7041 genotype may be associated with preterm labor
- Author
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Min-Chul Cho, In Ae Cho, Hyun Kyoung Seo, Min Ji Kang, Jae Yoon Jo, Jeong Kyu Shin, Soon Ae Lee, Seung Chan Kim, Rock-Bum Kim, and Won Jun Choi
- Subjects
Cross-Sectional Studies ,Obstetric Labor, Premature ,Genotype ,Pregnancy ,Vitamin D-Binding Protein ,Pediatrics, Perinatology and Child Health ,Infant, Newborn ,Obstetrics and Gynecology ,Humans ,Female ,Vitamin D ,Polymorphism, Single Nucleotide - Abstract
Vitamin D deficiency is common during pregnancy and may cause complications such as preterm labor (PTL). This study was aimed to investigate the effect of the vitamin D-binding protein (VDBP) rs7041 genotype, which has a significant effect on vitamin D metabolism and PTL.This cross-sectional study was conducted with 32 pregnant women who had spontaneous PTL and 54 pregnant women who had no specific findings as a control group. Serum total vitamin D 25-hydroxy vitamin D (25(OH)D) levels were measured using the Elecsys Vitamin D Total Kit. VDBP was measured using a VDBP Quantikine ELISA Kit. The levels of bioavailable 25(OH)D were calculated based on the total 25(OH)D and VDBP concentrations. DNA was extracted using the DNeasy Blood and Tissue Kit. Single nucleotide polymorphisms (rs7041) in GC were analyzed using a TaqMan SNP Genotyping Assay Kit. The unpairedTotal 25(OH)D levels were not significantly different between the two groups. Bioavailable 25(OH)D was significantly decreased in PTL women (Pregnant women with the VDBP rs7041(c.1296 T G) T allele genotype had reduced serum levels of bioavailable 25(OH)D and were more likely to develop PTL. Therefore, if the T allele is found in the VDBP rs7041 SNP genotyping test before or during pregnancy, more careful prenatal care may be required because of the increased risk of PTL.
- Published
- 2022
42. Vitamin D Status and Bone Health in Postmenopausal Women Working in Greenhouses
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Jae Yoon Jo, Yeon Jee Lee, Hyun Kyoung Seo, Min Ji Kang, In Ae Cho, Won Jun Choi, Seung Chan Kim, and Min-Chul Cho
- Abstract
Greenhouse workers synthesize less vitamin D because ultraviolet light is blocked by the vinyl that covers the greenhouses. This study aimed to investigate the vitamin D status and bone health of postmenopausal women working in greenhouses.This observational study enrolled women living in urban (n = 70, group 1) and rural areas (n = 91, group 2) and those working in greenhouses (n = 112, group 3). Serum levels of total and bioavailable 25-hydroxy-vitamin D [25(OH)D] and vitamin D binding protein were measured. T-scores of the lumbar spine and femur neck were measured by dual-energy X-ray absorptionetry.Heights were shorter in group 2 and group 3 than in group 1. Bioavailable 25(OH)D levels were higher and T-scores of the spine and femur were lower in both group 2 and 3 than in group 1. T-scores of the femur in group 3 were lower than those in group 2. The linear regression analysis showed that levels of bioavailable 25(OH)D significantly correlated with the spine T-scores but not with the femur T-scores. The prevalence of spinal osteoporosis was higher in both groups 2 and 3 compared to group 1. Group 3 demonstrated greater femur osteoporosis compared to groups 1 and 2.Vitamin D plays an important role in spinal bone health. Moreover, working conditions are likely to play an important role in femur bone health. Therefore, appropriate working conditions and nutrition are paramount to improve bone health in postmenopausal women working in greenhouses.
- Published
- 2021
43. Vitamin D Status and Bone Health in Postmenopausal Women Working in Greenhouses.
- Author
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Jae Yoon Jo, Yeon Jee Lee, Hyun Kyoung Seo, Min Ji Kang, In Ae Cho, Won Jun Choi, Seung Chan Kim, and Min-Chul Cho
- Subjects
VITAMIN D ,BONE health ,POSTMENOPAUSE ,GREENHOUSES ,BONE density - Abstract
Objectives: Greenhouse workers synthesize less vitamin D because ultraviolet light is blocked by the vinyl that covers the greenhouses. This study aimed to investigate the vitamin D status and bone health of postmenopausal women working in greenhouses. Methods: This observational study enrolled women living in urban (n = 70, group 1) and rural areas (n = 91, group 2) and those working in greenhouses (n = 112, group 3). Serum levels of total and bioavailable 25-hydroxy-vitamin D [25(OH)D] and vitamin D binding protein were measured. T-scores of the lumbar spine and femur neck were measured by dual-energy X-ray absorptionetry. Results: Heights were shorter in group 2 and group 3 than in group 1. Bioavailable 25(OH)D levels were higher and T-scores of the spine and femur were lower in both group 2 and 3 than in group 1. T-scores of the femur in group 3 were lower than those in group 2. The linear regression analysis showed that levels of bioavailable 25(OH)D significantly correlated with the spine T-scores but not with the femur T-scores. The prevalence of spinal osteoporosis was higher in both groups 2 and 3 compared to group 1. Group 3 demonstrated greater femur osteoporosis compared to groups 1 and 2. Conclusions: Vitamin D plays an important role in spinal bone health. Moreover, working conditions are likely to play an important role in femur bone health. Therefore, appropriate working conditions and nutrition are paramount to improve bone health in postmenopausal women working in greenhouses. [ABSTRACT FROM AUTHOR]
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- 2022
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44. Artificial Intelligence-Based Anomaly Detection Technology over Encrypted Traffic: A Systematic Literature Review
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Il Hwan Ji, Ju Hyeon Lee, Min Ji Kang, Woo Jin Park, Seung Ho Jeon, and Jung Taek Seo
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cyber security ,anomaly detection ,encrypted traffic ,Chemical technology ,TP1-1185 - Abstract
As cyber-attacks increase in unencrypted communication environments such as the traditional Internet, protected communication channels based on cryptographic protocols, such as transport layer security (TLS), have been introduced to the Internet. Accordingly, attackers have been carrying out cyber-attacks by hiding themselves in protected communication channels. However, the nature of channels protected by cryptographic protocols makes it difficult to distinguish between normal and malicious network traffic behaviors. This means that traditional anomaly detection models with features from packets extracted a deep packet inspection (DPI) have been neutralized. Recently, studies on anomaly detection using artificial intelligence (AI) and statistical characteristics of traffic have been proposed as an alternative. In this review, we provide a systematic review for AI-based anomaly detection techniques over encrypted traffic. We set several research questions on the review topic and collected research according to eligibility criteria. Through the screening process and quality assessment, 30 research articles were selected with high suitability to be included in the review from the collected literature. We reviewed the selected research in terms of dataset, feature extraction, feature selection, preprocessing, anomaly detection algorithm, and performance indicators. As a result of the literature review, it was confirmed that various techniques used for AI-based anomaly detection over encrypted traffic were used. Some techniques are similar to those used for AI-based anomaly detection over unencrypted traffic, but some technologies are different from those used for unencrypted traffic.
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- 2024
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45. Comparison of the Incidence of Nd:YAG Laser Capsulotomy Based on the Type of Intraocular Lens
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Yuri Lee, Jae Suk Kim, Bum Gi Kim, Je Hyung Hwang, Min Ji Kang, and Jee Hye Lee
- Subjects
intraocular lens ,Nd:YAG laser ,posterior capsule opacity ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Posterior capsular opacification (PCO) is the most common long-term complication of successful cataract surgery and can cause visual impairment. We aimed to investigate the effects of intraocular lens (IOL) characteristics on PCO by comparing the incidence of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy for different types of intraocular lenses. Materials and Methods: A retrospective analysis was performed on 2866 eyes that underwent cataract surgery between January 2010 and December 2017, with at least 5 years of follow-up. The IOLs used for surgery were the hydrophobic lenses SN60WF (Alcon, Fort Worth, TX, USA), ZCB00 (Johnson & Johnson Vision, Santa Ana, CA, USA), and MX60 (Bausch & Lomb, Rochester, NY, USA), and the hydrophilic lens MI60 (Bausch & Lomb, Rochester, NY, USA). We analyzed the incidence of Nd:YAG laser capsulotomy according to the type of IOL used. Results: The incidence of Nd:YAG laser capsulotomy was significantly higher with MI60 lenses (31.70%, 175/552 eyes) compared to SN60WF (7.90%, 113/1431 eyes), ZCB00 (10.06%, 64/636 eyes), and MX60 (10.57%, 13/123 eyes; p < 0.001) lenses. The incidence of Nd:YAG laser capsulotomy was significantly lower with the hydrophobic IOLs (8.68%, 190/2190 eyes) than with the hydrophilic IOL (31.70%, 175/552 eyes; p < 0.001). Over time, the rate of increase in the cumulative number of Nd:YAG laser capsulotomy cases was the highest with MI60. The cumulative rate of Nd:YAG laser capsulotomy during the first 3 years was 4.90% with SN60WF (70/1431 eyes), 6.76% with ZCB00 (43/636 eyes), 8.94% with MX60 (11/123 eyes), and 26.10% with MI60 (144/552 eyes) lenses. Conclusions: The incidence of PCO is influenced by the material of the IOLs. The hydrophilic IOL was associated with a higher rate of Nd:YAG laser capsulotomy than the hydrophobic IOLs, with a shorter time to Nd:YAG laser capsulotomy.
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- 2023
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46. Tissue Characterization Using an Electrical Bioimpedance Spectroscopy-Based Multi-Electrode Probe to Screen for Cervical Intraepithelial Neoplasia
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Tong In Oh, Min Ji Kang, You Jeong Jeong, Tingting Zhang, Seung Geun Yeo, and Dong Choon Park
- Subjects
CIN ,electrical impedance spectrum ,cancer screening ,bioimpedance spectroscopy ,multi-electrode screening probe ,Medicine (General) ,R5-920 - Abstract
The successful management of cervical intraepithelial neoplasia (CIN) with proper screening and treatment methods could prevent cervical cancer progression. We propose a bioimpedance spectroscopic measurement device and a multi-electrode probe as an independent screening tool for CIN. To evaluate the performance of this screening method, we enrolled 123 patients, including 69 patients with suspected CIN and 54 control patients without cervical dysplasia who underwent a hysterectomy for benign disease (non-CIN). Following conization, the electrical properties of the excised cervical tissue were characterized using an electrical bioimpedance spectroscopy-based multi-electrode probe. Twenty-eight multifrequency voltages were collected through the two concentric array electrodes via a sensitivity-optimized measurement protocol based on an electrical energy concentration method. The electrical properties of the CIN and non-CIN groups were compared with the results of the pathology reports. Reconstructed resistivity tended to decrease in the CIN and non-CIN groups as frequency increased. Reconstructed resistivity from 625 Hz to 50 kHz differed significantly between the CIN and non-CIN groups (p < 0.001). Using 100 kHz as the reference, the difference between the CIN and non-CIN groups was significant. Based on the difference in reconstructed resistivity between 100 kHz and the other frequencies, this method had a sensitivity of 94.3%, a specificity of 84%, and an accuracy of 90% in CIN screening. The feasibility of noninvasive CIN screening was confirmed through the difference in the frequency spectra evaluated in the excised tissue using the electrical bioimpedance spectroscopy-based multi-electrode screening probe.
- Published
- 2021
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47. [Comparison of open reduction hollow nail anchoring system with loop plate fixation under arthroscopy for the treatment of posterior cruciate ligament avulsion fractures].
- Author
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Wu R, Zhang ZF, Weng W, Yang HH, Min JK, Sun JW, and Shen ZY
- Subjects
- Humans, Male, Female, Middle Aged, Adult, Aged, Retrospective Studies, Fractures, Avulsion surgery, Bone Nails, Arthroscopy methods, Posterior Cruciate Ligament surgery, Posterior Cruciate Ligament injuries, Fracture Fixation, Internal methods, Fracture Fixation, Internal instrumentation, Bone Plates
- Abstract
Objective: To compare clinical effect between open reduction and fixation with cannulated screw and threaded rivet via posteromedial approach versus arthroscopic Endobutton plate fixation in treating posterior cruciate ligament avulsion fractures., Methods: Clinical data of 38 patients with posterior cruciate ligament avulsion fractures from July 2020 to December 2021 were analyzed retrospectively, and divided into open reduction and internal fixation group (posterior medial approach hollow anchor system fixation) and arthroscopic fixation group (Endobutton with loop plate fixation under arthroscopy). There were 20 patients in open reduction and internal fixation group, including 16 males and 4 females, aged from 26 to 74 years old with an average of (42.9±18.8) years old;13 patients on the left side and 7 patients on the right side;12 patients were classified to typeⅡand 8 patiens with type Ⅲ according to Meyers-McKeever fractures classification;14 patients were gradeⅡand 6 patients were grade Ⅲ in back drawer test. There were 18 patients in arthroscopic fixation group, including 11 males and 7 females;aged from 24 to 70 years old with an average of (53.5±13.4) years old;11 patients on the left side and 7 patients on the right side;10 patients were classified to typeⅡand 8 patiens with type Ⅲ according to Meyers-McKeever fractures classification;11 patients were gradeⅡand 7 patients were grade Ⅲ in back drawer test. Operation time, blood loss, and quality of immediate reduction were compared between two groups. Knee range of motion, knee back drawer test, and International Knee Documentation Committee(IKDC) grading, KT2000 stability evaluation and Lysholm function score of knee joint were compared at 6 months after operation., Results: All patients were followed up for 8 to 16 months with an average of (12.3±1.9) months. There were no complications such as incision infection, fracture malunion or non-union, and internal fixation loosening occurred. The avulsion fractures of knee joint were reached to imaging healing standard at 6 months after operation. Operation time and blood loss in open reduction and internal fixation group were (56.4±7.1) min and (63.2±10.2) ml, while (89.9±7.4) min and (27.7±8.7) ml in arthroscopic fixation group, respectively, and had significant difference between two groups ( P <0.05). There were no differences in immediate reduction quality ( χ
2 =0.257, P =0.612), knee joint range of motion at 6 months after opertaion ( t =0.492, P =0.626), knee joint rear drawer test ( χ2 =0.320, P =0.572), IKDC classification of knee joint ( χ2 =0.127, P =0.938), KT2000 stability evaluation ( χ2 =0.070, P =0.791), and knee Lysholm function score ( t =0.092, P =0.282) between two groups., Conclusion: Posterior medial approach with hollow anchoring system fixation and arthroscopic Endobutton with loop plate fixation for the treatment of posterior cruciate ligament tibial occlusion avulsion fracture could achieve satisfactory clinical results, and arthroscopic surgery has less bleeding, but also has a longer learning curve and longer operation time than traditional incision surgery. The surgeon needs to make a choice according to clinical situation of patient and their own surgical inclination.- Published
- 2024
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48. [Effect of Kümmell's disease with kyphosis on spinal-pelvic sagittal parameters].
- Author
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He SY, Min JK, Li HD, Zhang QH, and Dai JL
- Subjects
- Male, Female, Humans, Middle Aged, Aged, Retrospective Studies, Lumbar Vertebrae diagnostic imaging, Lumbar Vertebrae surgery, Pelvis diagnostic imaging, Lordosis diagnostic imaging, Kyphosis diagnostic imaging, Kyphosis surgery, Spondylosis
- Abstract
Objective: To explore the effect of Kümmell's disease with kyphosis on the sagittal morphology of the spine-pelvis., Methods: A retrospective analysis of 34 patients of Kümmell's disease with kyphosis (Kümmell group) admitted from August 2015 to September 2022, including 10 males and 24 females with an average age of (71.1±8.5) years old. A control group of 37 asymptomatic population aged (69.3±6.7) years old was matched. Spinal-pelvic sagittal parameters were measured on the anterior-posterior and lateral X-rays of the whole spine in the standing position, including segmental kyphosis(SK) or thoracolumbar kyphosis(TLK), thoracic kyphosis(TK), lumbar lordosis(LL), pelvic incidence(PI), pelvic tilt(PT), sacral slope(SS), sagittal vertical axis(SVA), T1 pelvic angle(TPA) and PI-LL. Vertebral wedge angle(WA) in Kümmell was measured and differences in parameters among groups were analyzed and the relationship between spino-pelvic parameters and WA, SK were also investigated., Results: TK, SK, PT, SVA, TPA and PI-LL in Kümmell group were significantly larger than those in control group ( P <0.05), LL and SS in Kümmell group were significantly decreased than those in control group ( P <0.05), and there was no significant difference in PI between two groups ( P >0.05). In Kümmell group, WA(30.8±5.9)° showed a positive correlation with SK and TK( r =0.366, 0.597, P <0.05), and SK was significantly correlated with LL and SS( r =0.539, -0.591, P <0.05). Strong positive correlation between LL and PI, SS, SVA, TPA, PI-LL were also confirmed in patients with Kümmell with kyphosis( r =0.559, 0.741, -0.273, -0.356, -0.882, P <0.05)., Conclusion: Patients with Kümmell with kyphosis not only have segmental kyphosis, but also changes the overall spinal-pelvic sagittal parameters, including loss of lumbar lordosis, pelvic retrorotation, trunk forward tilt. The surgical treatment of Kümmell disease should not only pay attention to the recovery of the height of the collapsed vertebra, but also focus on the overall balance of the spine-pelvic sagittal plane for patients with kyphosis.
- Published
- 2024
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- View/download PDF
49. [Effect of morphological changes in the sagittal plane of vertebrae and discs on degenerative kyphodeformity].
- Author
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He SY, Li HD, Min JK, Luo SC, and Dai JL
- Subjects
- Male, Adult, Female, Humans, Middle Aged, Aged, Retrospective Studies, Thoracic Vertebrae diagnostic imaging, Lumbar Vertebrae diagnostic imaging, Kyphosis, Scoliosis, Intervertebral Disc
- Abstract
Objective: To explore the effects of morphological changes such as vertebral wedge deformation and disc degeneration (collapse) on adult thoracolumbar/lumbar degenerative kyphosis(TL/LDK) deformity., Methods: A retrospective analysis of 32 patients with spinal TL/LDK deformity admitted from August 2015 to December 2020, including 8 males and 24 females, aged 48 to 75(60.3±12.4) years old. On the long-cassette standing upright lateral radiographs, the coronal Cobb angle, sagittal thoracic lumbar/lumbar kyphosis angle(KA) of spine were measured, and the height and wedge parameters of apex vertebral(AV) and two vertebrae(AV-1, AV-2, AV+1, AV+2) above and below AV and the intervertebrae and the intervertebral disc(AV-1D, AV-2D, AV+1D, AV+2D) were evaluated, involving anterior vertebral body height(AVH), posterior vertebral body height(PVH), vertebral wedge angle(VWA), ratio of vertebral wedging(RVW), anterior disc height(ADH), posterior disc height(PDH), disc wedge angle(DWA), ratio of disc wedging(RDW), and DWA/KA., Results: The average angle of kyphosis was (44.2±19.1)°. A significant decrease in anterior height of vertebral was observed compared to the posterior height of vertebral( P <0.005). There was no significant difference in anterior and posterior height of discs. The vertebral wedging ratio/contribution ratio:AV-2(14.98±10.95)%/(14.21±8.08)%, AV-1(21.08±12.39)%/(18.09±7.38)%, AV(26.94±11.94)%/(25.52±8.64)%, AV+1(24.19±8.42)%/(20.82±8.69)%, AV+2(20.56±7.80)%/(15.60±9.71)%, total contribution(94.23±22.25)%, the disc wedging ratio/contribution ratio:AV-2D(2.88±2.57)%/(5.27±4.11)%, AV-1D(1.98±1.41)%/(2.29±2.16)%, AV+1D(-5.54±3.75)%/(-0.57±0.46)%, AV+2D(-8.27±4.62)%/(-1.22±1.11)%, total contribution (5.77±4.79)%. And the contribution rate of AV was significantly higher than that of adjacent vertebral( P <0.05)., Conclusion: The vertebral body and intervertebral disc shape both have influence on thoracolumbar kyphosis. However, the contribution of vertebral morphometry to the angle of TL/LDK deformity is relatively more important than the disc. The contribution of the wedge change of the AV to the TL/LDK deformity is particularly significant.
- Published
- 2023
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50. [Treatment of acetabular fracture involving quadrilateral body by external rectus abdominis incision combined with calcaneal profiled plate internal fixation].
- Author
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Zhu XH, Min JK, Zhang QH, Guo SH, Li HD, and Zhu ZL
- Subjects
- Male, Female, Humans, Young Adult, Adult, Middle Aged, Aged, Rectus Abdominis, Retrospective Studies, Acetabulum surgery, Acetabulum injuries, Bone Plates, Hip Fractures surgery, Spinal Fractures
- Abstract
Objective: To investigate the therapeutic effect of lateral rectus abdominis incision combined with winged calcaneal plate on pelvic and acetabular fractures involving quadrilateral body., Methods: From January 2017 to April 2021, 21 cases of pelvic and acetabular fractures involving quadrilateral bodies were retrospectively analyzed, including 12 males and 9 females. The age ranged from 21 to 73 years with an average of (43.23±6.45) years. All patients were treated by lateral incision of rectus abdominis combined with open reduction and internal fixation with aerofoil plate, including 12 cases of pelvis with anterior and posterior column fractures, 7 cases of acetabular fractures with quadrilateral involvement, and 2 cases of acetabular fractures with central dislocation., Results: All 21 patients were followed up for 12 to 36 months with an average of (18.60±6.45) months. All fractures healed. According to Matta's image reduction evaluation after operation, 11 cases of pelvic anterior and posterior column fractures were all anatomic reduction, 1 case was satisfactory reduction, 7 cases of acetabular fractures involving quadrilateral were anatomic reduction, 1 case with central dislocation was anatomic reduction, and 1 case was satisfactory reduction. The modified Merle D'Aubigne Postel hip joint score was 13 to 17 points., Conclusion: Lateral incision approach of rectus abdominis combined with wing-shaped steel plate can obtain good radiological and clinical results in the treatment of complex pelvic and acetabular fractures involving quadrilateral bodies, and has advantages in the treatment of complex pelvic fractures and acetabular quadrilateral fractures.
- Published
- 2022
- Full Text
- View/download PDF
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