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17. Data from miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells

Author

Mazzu, Ying Z., primary, Hu, Yulan, primary, Soni, Rajesh K., primary, Mojica, Kelly M., primary, Qin, Li-Xuan, primary, Agius, Phaedra, primary, Waxman, Zachary M., primary, Mihailovic, Aleksandra, primary, Socci, Nicholas D., primary, Hendrickson, Ronald C., primary, Tuschl, Thomas, primary, and Singer, Samuel, primary

Published
2023
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18. Supplementary Figures S1-S9 from miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells

Author

Mazzu, Ying Z., primary, Hu, Yulan, primary, Soni, Rajesh K., primary, Mojica, Kelly M., primary, Qin, Li-Xuan, primary, Agius, Phaedra, primary, Waxman, Zachary M., primary, Mihailovic, Aleksandra, primary, Socci, Nicholas D., primary, Hendrickson, Ronald C., primary, Tuschl, Thomas, primary, and Singer, Samuel, primary

Published
2023
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19. Supplementary Tables S1-S7 from miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells

Author

Mazzu, Ying Z., primary, Hu, Yulan, primary, Soni, Rajesh K., primary, Mojica, Kelly M., primary, Qin, Li-Xuan, primary, Agius, Phaedra, primary, Waxman, Zachary M., primary, Mihailovic, Aleksandra, primary, Socci, Nicholas D., primary, Hendrickson, Ronald C., primary, Tuschl, Thomas, primary, and Singer, Samuel, primary

Published
2023
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20. Supplementary methods and figure legends from miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells

Author

Mazzu, Ying Z., primary, Hu, Yulan, primary, Soni, Rajesh K., primary, Mojica, Kelly M., primary, Qin, Li-Xuan, primary, Agius, Phaedra, primary, Waxman, Zachary M., primary, Mihailovic, Aleksandra, primary, Socci, Nicholas D., primary, Hendrickson, Ronald C., primary, Tuschl, Thomas, primary, and Singer, Samuel, primary

Published
2023
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21. Data from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Author

Farazi, Thalia A., primary, Horlings, Hugo M., primary, ten Hoeve, Jelle J., primary, Mihailovic, Aleksandra, primary, Halfwerk, Hans, primary, Morozov, Pavel, primary, Brown, Miguel, primary, Hafner, Markus, primary, Reyal, Fabien, primary, van Kouwenhove, Marieke, primary, Kreike, Bas, primary, Sie, Daoud, primary, Hovestadt, Volker, primary, Wessels, Lodewyk F.A., primary, van de Vijver, Marc J., primary, and Tuschl, Thomas, primary

Published
2023
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22. Data from Small RNA Sequencing and Functional Characterization Reveals MicroRNA-143 Tumor Suppressor Activity in Liposarcoma

Author

Ugras, Stacy, primary, Brill, Elliott, primary, Jacobsen, Anders, primary, Hafner, Markus, primary, Socci, Nicholas D., primary, DeCarolis, Penelope L., primary, Khanin, Raya, primary, O'Connor, Rachael, primary, Mihailovic, Aleksandra, primary, Taylor, Barry S., primary, Sheridan, Robert, primary, Gimble, Jeffrey M., primary, Viale, Agnes, primary, Crago, Aimee, primary, Antonescu, Cristina R., primary, Sander, Chris, primary, Tuschl, Thomas, primary, and Singer, Samuel, primary

Published
2023
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23. Supplementary Methods, Tables 1-4, Figures 1-7 from Small RNA Sequencing and Functional Characterization Reveals MicroRNA-143 Tumor Suppressor Activity in Liposarcoma

Author

Ugras, Stacy, primary, Brill, Elliott, primary, Jacobsen, Anders, primary, Hafner, Markus, primary, Socci, Nicholas D., primary, DeCarolis, Penelope L., primary, Khanin, Raya, primary, O'Connor, Rachael, primary, Mihailovic, Aleksandra, primary, Taylor, Barry S., primary, Sheridan, Robert, primary, Gimble, Jeffrey M., primary, Viale, Agnes, primary, Crago, Aimee, primary, Antonescu, Cristina R., primary, Sander, Chris, primary, Tuschl, Thomas, primary, and Singer, Samuel, primary

Published
2023
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24. Supplementary Figure 3 from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Author

Farazi, Thalia A., primary, Horlings, Hugo M., primary, ten Hoeve, Jelle J., primary, Mihailovic, Aleksandra, primary, Halfwerk, Hans, primary, Morozov, Pavel, primary, Brown, Miguel, primary, Hafner, Markus, primary, Reyal, Fabien, primary, van Kouwenhove, Marieke, primary, Kreike, Bas, primary, Sie, Daoud, primary, Hovestadt, Volker, primary, Wessels, Lodewyk F.A., primary, van de Vijver, Marc J., primary, and Tuschl, Thomas, primary

Published
2023
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25. Supplementary Figure 5 from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Author

Farazi, Thalia A., primary, Horlings, Hugo M., primary, ten Hoeve, Jelle J., primary, Mihailovic, Aleksandra, primary, Halfwerk, Hans, primary, Morozov, Pavel, primary, Brown, Miguel, primary, Hafner, Markus, primary, Reyal, Fabien, primary, van Kouwenhove, Marieke, primary, Kreike, Bas, primary, Sie, Daoud, primary, Hovestadt, Volker, primary, Wessels, Lodewyk F.A., primary, van de Vijver, Marc J., primary, and Tuschl, Thomas, primary

Published
2023
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26. Supplementary Figure 4 from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Author

Farazi, Thalia A., primary, Horlings, Hugo M., primary, ten Hoeve, Jelle J., primary, Mihailovic, Aleksandra, primary, Halfwerk, Hans, primary, Morozov, Pavel, primary, Brown, Miguel, primary, Hafner, Markus, primary, Reyal, Fabien, primary, van Kouwenhove, Marieke, primary, Kreike, Bas, primary, Sie, Daoud, primary, Hovestadt, Volker, primary, Wessels, Lodewyk F.A., primary, van de Vijver, Marc J., primary, and Tuschl, Thomas, primary

Published
2023
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27. Supplementary Figure 2B from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Author

Farazi, Thalia A., primary, Horlings, Hugo M., primary, ten Hoeve, Jelle J., primary, Mihailovic, Aleksandra, primary, Halfwerk, Hans, primary, Morozov, Pavel, primary, Brown, Miguel, primary, Hafner, Markus, primary, Reyal, Fabien, primary, van Kouwenhove, Marieke, primary, Kreike, Bas, primary, Sie, Daoud, primary, Hovestadt, Volker, primary, Wessels, Lodewyk F.A., primary, van de Vijver, Marc J., primary, and Tuschl, Thomas, primary

Published
2023
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28. Supplementary Figure 1 from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Author

Farazi, Thalia A., primary, Horlings, Hugo M., primary, ten Hoeve, Jelle J., primary, Mihailovic, Aleksandra, primary, Halfwerk, Hans, primary, Morozov, Pavel, primary, Brown, Miguel, primary, Hafner, Markus, primary, Reyal, Fabien, primary, van Kouwenhove, Marieke, primary, Kreike, Bas, primary, Sie, Daoud, primary, Hovestadt, Volker, primary, Wessels, Lodewyk F.A., primary, van de Vijver, Marc J., primary, and Tuschl, Thomas, primary

Published
2023
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29. Supplementary Methods, Figure and Table Legends from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Author

Farazi, Thalia A., primary, Horlings, Hugo M., primary, ten Hoeve, Jelle J., primary, Mihailovic, Aleksandra, primary, Halfwerk, Hans, primary, Morozov, Pavel, primary, Brown, Miguel, primary, Hafner, Markus, primary, Reyal, Fabien, primary, van Kouwenhove, Marieke, primary, Kreike, Bas, primary, Sie, Daoud, primary, Hovestadt, Volker, primary, Wessels, Lodewyk F.A., primary, van de Vijver, Marc J., primary, and Tuschl, Thomas, primary

Published
2023
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30. Supplementary Figure 6 from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Author

Farazi, Thalia A., primary, Horlings, Hugo M., primary, ten Hoeve, Jelle J., primary, Mihailovic, Aleksandra, primary, Halfwerk, Hans, primary, Morozov, Pavel, primary, Brown, Miguel, primary, Hafner, Markus, primary, Reyal, Fabien, primary, van Kouwenhove, Marieke, primary, Kreike, Bas, primary, Sie, Daoud, primary, Hovestadt, Volker, primary, Wessels, Lodewyk F.A., primary, van de Vijver, Marc J., primary, and Tuschl, Thomas, primary

Published
2023
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31. Supplementary Tables 1-8C from MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Author

Farazi, Thalia A., primary, Horlings, Hugo M., primary, ten Hoeve, Jelle J., primary, Mihailovic, Aleksandra, primary, Halfwerk, Hans, primary, Morozov, Pavel, primary, Brown, Miguel, primary, Hafner, Markus, primary, Reyal, Fabien, primary, van Kouwenhove, Marieke, primary, Kreike, Bas, primary, Sie, Daoud, primary, Hovestadt, Volker, primary, Wessels, Lodewyk F.A., primary, van de Vijver, Marc J., primary, and Tuschl, Thomas, primary

Published
2023
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32. Associations among Visual, Auditory, and Olfactory Functions in Community-Based Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

Author

Arsiwala-Scheppach, Lubaina T., primary, Ramulu, Pradeep Y., additional, Sharrett, A. Richey, additional, Kamath, Vidyulata, additional, Deal, Jennifer A., additional, Guo, Xinxing, additional, Du, Simo, additional, Garcia Morales, Emmanuel E., additional, Mihailovic, Aleksandra, additional, Chen, Honglei, additional, and Abraham, Alison G., additional

Published
2022
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34. Association of Optical Coherence Tomography and Optical Coherence Tomography Angiography Retinal Features With Visual Function in Older Adults

Author

Dong, Yanan, primary, Guo, Xinxing, additional, Arsiwala-Scheppach, Lubaina T., additional, Sharrett, A. Richey, additional, Ramulu, Pradeep Y., additional, Mihailovic, Aleksandra, additional, Pan-Doh, Nathan, additional, Mosley, Thomas, additional, Coresh, Josef, additional, and Abraham, Alison G., additional

Published
2022
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37. APOE4 Allele, Sex, and Dementia Risk in Parkinson's Disease: Lessons From a Longitudinal Cohort.

Author

Umeh, Chizoba C., Mahajan, Abhimanyu, Mihailovic, Aleksandra, and Pontone, Gregory M.

Subjects
PARKINSON'S disease, DISEASE risk factors, APOLIPOPROTEIN E, ALZHEIMER'S disease, ALLELES, APOLIPOPROTEIN E4
Abstract

Introduction: The effect of APOE4 allele on dementia risk is well established in Alzheimer's disease and Parkinson's disease (PD). However, it is unknown if sex modifies this relationship. We sought to determine the effect of sex on the relationship between APOE4 status and incident cognitive decline in PD. Methods: Data from the prospectively collected longitudinal National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) and Neuropathology Data Set (NDS) were analyzed. The NACC develops and maintains data from approximately 29 National Institutes of Aging-funded Alzheimer's Disease Research Centers. Further details may be found at the NACC web site (www.alz.washington.edu). The visit at which diagnosis of PD was made was termed the baseline visit. All patients with a PD diagnosis but without dementia at the baseline visit were included in the analyses. Results: Presence of APOE4 allele was associated with higher odds (OR = 7.4; P <.001) of subsequent diagnosis of dementia and with a faster time to developing dementia (P =.04). Those with APOE4 allele were more likely to have neuropathology associated with Alzheimer's disease than those without APOE4 allele. We did not find any difference by sex. There were no differences between Lewy body pathology or neuron loss in the substantia nigra between the 2 groups. Sex was not associated with dementia risk in PD (OR = 0.53, P =.15) or with the time to dementia onset (P =.22). Sex did not modify the relationship between the APOE4 allele and dementia onset in PD patients (P =.12) Conclusions: APOE4 allele status in PD may be a predictor of cognitive decline in PD but does not appear to be modified by sex. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Associations of Visual Function With Cognitive Performance in Community-Based Older Adults: The Eye Determinants of Cognition Study.

Author

Arsiwala, Lubaina T, Guo, Xinxing, Ramulu, Pradeep Y, Sharrett, A Richey, Mihailovic, Aleksandra, Swenor, Bonnielin K, Mosley, Thomas, Dong, YaNan, and Abraham, Alison G

Subjects
VISION, COGNITIVE ability, CONTRAST sensitivity (Vision), EXECUTIVE function, GENERALIZED estimating equations, COGNITION disorders, COGNITION, VISUAL acuity, RESEARCH funding, VISION disorders
Abstract

Background: Given the detrimental impacts of visual and cognitive impairment separately, in older adults, understanding their coexistence could inform strategies against age-related cognitive changes.Methods: Participants from Washington County (White) and Jackson (Black) sites of the Atherosclerosis Risk in Communities Study were recruited who differed on racial, regional, urbanicity, and community-based factors. Presenting distance visual acuity (DVA; representing vision loss due to disease or lack of eye-care), corrected DVA (representing optimal correction for refractive loss of vision), and contrast sensitivity were measured. Factor scores for global cognition, memory, executive function, and language domains were calculated for 3 visits. We quantified the associations of vision measures with change in cognitive scores, stratified by community/race, using generalized estimating equations.Results: In 982 participants, mean (standard deviation [SD]) baseline age was 74 (4) years, with 37% males and 45% Jackson/Black participants. As hypothesized, after accounting for potential confounders, in the better-eye, worse presenting DVA was associated with greater 10-year decline rate in global cognition, memory, and executive function in Washington County/White participants (eg, global cognition: -0.08 SD [95% confidence interval: -0.12, -0.04]). Worse corrected DVA was associated with greater 10-year decline rate in executive function in Washington County/White participants (-0.10 SD [-0.15, -0.04]). Better contrast sensitivity was associated with lower 10-year decline rate in global cognition and executive function in Washington County/White participants (eg, global cognition: 0.10 SD [0.06,0.14]). None of these associations were confirmed in Jackson/Black participants.Conclusions: Our study supports a functional link between some vision measures and cognition in older adults, but in only 1 of the 2 communities studied. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Prediction of MIGS outcomes on second eyes using first eyes’ response

Author

Dickinson, Anna, Leidy, Luke, Nusair, Omar, Rachapudi, Sruti, Valenzuela, Tony, Ramulu, Pradeep, Mihailovic, Aleksandra, Yohannan, Jithin, Kaleem, Mona, Johnson, Thomas V., and An, Jella

Abstract

To evaluate how well outcomes following cataract extraction and microinvasive glaucoma surgery in one eye predict outcomes in sequential second eye. Retrospective study of 78 patients who underwent cataract extraction and microinvasive glaucoma surgery in both eyes. Linear regressions using Pearson correlation coefficients were used to evaluate correlations in intraocular pressure and glaucoma medication change between eyes. Multivariable logistic regression models were used to evaluate the associations between first-eye variables and the likelihood of second-eye surgical success at 6 months. Surgical success was defined as meeting target intraocular pressure without additional medications compared to baseline or secondary surgical interventions. Baseline ocular characteristics were comparable between fellow eyes, with the majority having mild glaucoma. Intraocular pressure changes between fellow eyes at 6 months were modestly correlated between eyes (R = 0.48; P < .001). Changes in glaucoma medications were strongly correlated between eyes at all time points, and month 6 demonstrated the most significant correlation (R = 0.80; P < .001). First and second eye cohorts achieved 82% and 83% surgical success. Multivariate analysis for predictive factors of successful second eye surgery showed patients with successful first eye surgery at 6 months were significantly more likely to have successful second eye surgery (odds ratio, 20.67; P < .001). Reductions in intraocular pressure and glaucoma medications at 6 months following surgery in first eyes are correlated to second eye reductions. Successful surgical outcomes at 6 months following first eye surgeries are strongly associated with successful sequential second eye outcomes.

Published
2023
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40. The Quantitative Impact of Visual Function on Accelerometer-measured Physical Activity in Older United States Adults: A Nationwide Cross-sectional Analysis.

Author

Almidani L, Varadaraj V, Banerjee S, E JY, Mihailovic A, and Ramulu PY

Abstract

Purpose: To explore the impact of objective vision measures on novel metrics of objectively-measured physical activity (PA) in a nationally representative sample of United States (US) older adults., Design: Cross-sectional analysis using data from the National Health and Aging Trends Study., Participants: Adults had their distance and near visual acuity (VA) and contrast sensitivity (CS) tested. Any objective vision impairment (VI), defined as any VI in distance VA, near VA, or CS, was the primary exposure. Physical activity data were collected using the Actigraph CentrePoint Insight Watch worn for 7 days., Methods: Multivariable regression models were used to investigate the association between vision and PA measures. All analyses accounted for the survey design and models were adjusted for age, sex, race, living arrangement, education, and comorbidities., Main Outcome Measures: Physical activity metrics included (1) total daily activity (active minutes per day, number of active bouts, and mean length of active bouts), (2) activity fragmentation, and (3) time until 75% activity. An active bout was defined as ≥ 1 consecutive active minute. Activity fragmentation was defined as the probability of an active minute being followed by a sedentary minute, with higher values indicating more fragmented activity. Time until 75% activity was defined as the time taken to complete 75% of daily PA starting from their first active bout., Results: Among 723 participants, sampled from 10 443 338 older adults in the US, 30% had any objective VI. Any objective VI was significantly associated with lower number of active minutes per day (7.8% fewer [95% confidence interval {CI}: -13.6% to -1.7%]), shorter active bouts (7.0% shorter [95% CI: -12.3% to -1.4%]), and greater activity fragmentation (2.5% [95% CI: 0.8% to 4.2%]), while no associations were found with number of active bouts. Time until 75% activity did not significantly differ between adults with any objective VI and those without ( P  = 0.34)., Conclusions: Older US adults with any objective VI displayed lower total daily activity, as well as more fragmented, shorter periods of PA, despite having a similar number of active bouts compared to their normally sighted counterparts. Implementing interventions that increase bout duration may help promote PA in adults with VI., Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article., (© 2023 by the American Academy of Ophthalmology.)

Published
2023
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