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"The random design is the simplest of all the designs that are used to compare two or more treatments. The analysis of variance is the central technique in the analysis of experimental data, the general idea of this technique is to separate the total variation in the parts which contributes each source of variation in the experiment. In the case of the random design, separates the variability of treatment. To facilitate education students, it focused on interpreting the results and not developing. It is important to use new technologies as a support to the teaching of the subject, in this document we propose different forms of feedback to the subject as statistical software, specialized web pages, applets, and virtual labs. In this work an E-Learning course was developed on the platform Dokeos as support for the traditional kinds of design of experiments. In which, the subject of analysis of variance explains in a simple way what is the random design. The Dokeos platform was used because it is a free software based online learning suite and provides all the features that an online learning application needs, from the authorship of courses up to reports. The objective was to adapt the above mentioned subject to an E-learning model in order (a) optimize the contribution of content, skills, and competencies that students must have, (b) the integration of statistical software in courses to emphasize applications to the real problems as contexts, concepts and methods, (c) the development of interactive materials that facilitate updating and learning by experimentation, (d) the use of a model of continuous assessment that guide and prepare the students in their formation, (e) the participation of the collaborative learning online by assigning projects and activities to be carried out in working groups. E-learning course helps students for three things. First, to save time, since they have different tools that help to solve real problems. Second, they make use of computer science to understand the themes of the platform and at the same time are at the forefront of technology. On the other hand, it is also transmitted to the students the idea that learning is a continuous process and that it should be done. Third, show students that these tools offered the platform is not important memorizing formulas or perform arithmetic calculations, if not who can concentrate on results more quickly. The third, show that students with these tools offered by the platform is not as important memorizing formulas or perform arithmetic calculations, if not who can concentrate on results more quickly."

"These are the advantages of technology: multimedia presentation, interaction, personalization, etc. Within this context an interactive digital book of the characteristics of the information was realized. In a data set, the following characteristics are usually of paramount importance: 1. the center, 2. the variation, 3. the distribution, 4. the atypical values and 5. The characteristics of the data that change over time. It is important to understand the standard deviation values using tools such as the general rule of rank. Because technology allows us to get many of these statistics automatically, it is not so important to memorize formulas or perform complex arithmetic calculations by hand on the other hand, so that the students can concentrate on understanding and interpreting the values that are obtained from them. The interactive digital book of measures of central tendency contemplates that each chapter indicates prerequisites, learning objectives, written development of the subject, videos with explanation, interactive exercises, widget (html 5. Interactive galleries, interactive images, etc.) review questions. The interactive digital book will provide students with full-screen experience with galleries, videos, interactive diagrams, 3D objects, and math expressions and more; these books give life to the content in ways that a printed page cannot do. Students will no longer be limited to static images that illustrate traditional texts, but can now immerse themselves in an image with interactive subtitles, rotate a 3D object or make an answer come to life in a chapter review. You can flip through a book with a single finger on the screen. They can also highlight text, take notes, look up content and find definitions in a glossary very easily. In addition, they can take them wherever they go, which will allow students not only to learn between the walls of the classroom, but also in the virtual space that make up these books."

[EN] These are the advantages of technology: multimedia presentation, interaction, personalization, etc. Within this context an interactive digital book of the characteristics of the information was realized. In a data set, the following characteristics are usually of paramount importance: 1. the center, 2. the variation, 3. the distribution, 4. the atypical values and 5. The characteristics of the data that change over time. It is important to understand the standard deviation values using tools such as the general rule of rank. Because technology allows us to get many of these statistics automatically, it is not so important to memorize formulas or perform complex arithmetic calculations by hand on the other hand, so that the students can concentrate on understanding and interpreting the values that are obtained from them.The interactive digital book of measures of central tendency contemplates that each chapter indicates prerequisites, learning objectives, written development of the subject, videos with explanation, interactive exercises, widget (html 5. Interactive galleries, interactive images, etc.) review questions.The interactive digital book will provide students with full-screen experience with galleries, videos, interactive diagrams, 3D objects, and math expressions and more; these books give life to the content in ways that a printed page can not do. Students will no longer be limited to static images that illustrate traditional texts, but can now immerse themselves in an image with interactive subtitles, rotate a 3D object or make an answer come to life in a chapter review. You can flip through a book with a single finger on the screen. They can also highlight text, take notes, look up content and find definitions in a glossary very easily. In addition, they can take them wherever they go, which will allow students not only to learn between the walls of the classroom, but also in the virtual space that make up these books., To the PAPIME 104420, project for the support provided in carrying out this work

Ample evidence supports the prominent role of gut-liver axis in perpetuating pathological networks of high-fat high-fructose (HFF) diet induced metabolic disorders, however, the molecular mechanisms are still not fully understood. Herein, this study aims to present a holistic delineation and scientific explanation for the crosstalk between the gut and liver, including the potential mediators involved in orchestrating the metabolic and immune systems.An experimental obesity-associated metaflammation rat model is induced with a HFF diet. An integrative multi-omics analysis is then performed. Following the clues illustrated by the multi-omics discoveries, putative pathways are subsequently validated by RT-qPCR and Western blotting. HFF diet leads to obese phenotypes in rats, as well as histopathological changes. Integrated omics analysis shows that there exists a strong interdependence among gut microbiota composition, intestinal metabolites, and innate immunity regulation in the liver. Some carboxylic acids may contribute to gut-liver communication. Moreover, activation of the hepatic LPS-TLR4 pathway in obesity is confirmed.HFF-intake disturbs gut flora homeostasis. Crosstalk between gut microbiota and innate immune system mediates hepatic metaflammation in obese rats, associated with LPS-TLR4 signaling pathway activation. Moreover, α-hydroxyisobutyric acid and some other organic acids may play a role as messengers in the liver-gut axis.