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Your search keyword '"Michael, Anglesio"' showing total 3 results
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3 results on '"Michael, Anglesio"'

1. Multisite gynecologic endometrioid adenocarcinomas: Can mutation profiling be used to distinguish synchronous primary cancers from metastases?

Author

Dominique Barnes, Nissreen Mohammad, Lien Hoang, Michael Anglesio, Robert L. Hollis, Charlie Gourley, Heather C. Stuart, Mark S. Carey, and Gavin C.E. Stuart

Subjects
Endometrioid carcinoma, Mutation analysis, Clonality, Gynecologic cancers, Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

It is well recognized that some patients with endometrioid gynecological cancers have tumors arising in multiple sites (ovary, endometrium, and endometriosis) at the time of diagnosis. Molecular analysis has helped discern whether these multisite cancers represent synchronous primary tumors or alternatively metastatic disease. We present a complex case of a patient with endometrioid carcinomas arising in multiple sites. We discuss the use of mutation profiling to discern clonality and highlight how this information may inform the clinical management of such cases.

Published
2022
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2. O031/#777 Lymphadenectomy in endometrioid ovarian carcinoma patients with early stage disease: results from the leopard trial

Author

Marcel Grube, Andrea Neilson, Marie Plante, Koen Brummel, Cornelis De Kroon, Fabienne Schochter, Michail Sideris, Florian Heitz, Thomas Bartl, Sabine Heublein, Barbara Vanderhyden, Pauline Wimberger, Barbara Schmalfeldt, Björn Lampe, Amber Yasmeen, Larry Phouthavongsy, Ranjit Manchanda, Hans Nijman, Friedrich Kommoss, Michael Anglesio, and Stefan Kommoss

Published
2022

3. The proteome of clear cell ovarian carcinoma

Author

Jennifer X Ji, Dawn R Cochrane, Gian Luca Negri, Shane Colborne, Sandra E Spencer Miko, Lynn N Hoang, David Farnell, Basile Tessier‐Cloutier, Jutta Huvila, Emily Thompson, Samuel Leung, Derek Chiu, Christine Chow, Monica Ta, Martin Köbel, Lucas Feil, Michael Anglesio, Ellen L Goode, Kelly Bolton, Gregg B Morin, and David G Huntsman

Subjects
Proteomics, Ovarian Neoplasms, Proteome, Humans, Female, Carcinoma, Ovarian Epithelial, Article, Pathology and Forensic Medicine, Adenocarcinoma, Clear Cell
Abstract

Clear cell ovarian carcinoma (CCOC) is the second most common subtype of epithelial ovarian carcinoma. Late-stage CCOC is not responsive to gold-standard chemotherapy and results in suboptimal outcomes for patients. In-depth molecular insight is urgently needed to stratify the disease and drive therapeutic development. We conducted global proteomics for 192 cases of CCOC and compared these with other epithelial ovarian carcinoma subtypes. Our results showed distinct proteomic differences in CCOC compared with other epithelial ovarian cancer subtypes including alterations in lipid and purine metabolism pathways. Furthermore, we report potential clinically significant proteomic subgroups within CCOC, suggesting the biologic plausibility of stratified treatment for this cancer. Taken together, our results provide a comprehensive understanding of the CCOC proteomic landscape to facilitate future understanding and research of this disease. © 2022 The Pathological Society of Great Britain and Ireland.

Published
2022

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