303 results on '"Merlos, A."'
Search Results
2. Making Thermal Imaging More Equitable and Accurate: Resolving Solar Loading Biases
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Zhao, Ellin Q., Vilesov, Alexander, Athreya, Shreeram, Chari, Pradyumna, Merlos, Jeanette, Millett, Kendall, Cyr, Nia St., Jalilian, Laleh, and Kadambi, Achuta
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Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Thermal cameras and thermal point detectors are used to measure the temperature of human skin. These are important devices that are used everyday in clinical and mass screening settings, particularly in an epidemic. Unfortunately, despite the wide use of thermal sensors, the temperature estimates from thermal sensors do not work well in uncontrolled scene conditions. Previous work has studied the effect of wind and other environment factors on skin temperature, but has not considered the heating effect from sunlight, which is termed solar loading. Existing device manufacturers recommend that a subject who has been outdoors in sun re-acclimate to an indoor environment after a waiting period. The waiting period, up to 30 minutes, is insufficient for a rapid screening tool. Moreover, the error bias from solar loading is greater for darker skin tones since melanin absorbs solar radiation. This paper explores two approaches to address this problem. The first approach uses transient behavior of cooling to more quickly extrapolate the steady state temperature. A second approach explores the spatial modulation of solar loading, to propose single-shot correction with a wide-field thermal camera. A real world dataset comprising of thermal point, thermal image, subjective, and objective measurements of melanin is collected with statistical significance for the effect size observed. The single-shot correction scheme is shown to eliminate solar loading bias in the time of a typical frame exposure (33ms).
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- 2023
3. Adopting yield-improving practices to meet maize demand in Sub-Saharan Africa without cropland expansion
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Fernando Aramburu-Merlos, Fatima A. M. Tenorio, Nester Mashingaidze, Alex Sananka, Stephen Aston, Jonathan J. Ojeda, and Patricio Grassini
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Science - Abstract
Abstract Maize demand in Sub-Saharan Africa is expected to increase 2.3 times during the next 30 years driven by demographic and dietary changes. Over the past two decades, the area cropped with maize has expanded by 17 million hectares in the region, with limited yield increase. Following this trend could potentially result in further maize cropland expansion and the need for imports to satisfy domestic demand. Here, we use data collected from 14,773 smallholder fields in the region to identify agronomic practices that can improve farm yield gains. We find that agronomic practices related to cultivar selection, and nutrient, pest, and crop management can double on-farm yields and provide an additional 82 million tons of maize within current cropped area. Research and development investments should be oriented towards agricultural practices with proven capacity to raise maize yields in the region.
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- 2024
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4. Estimating lime requirements for tropical soils: Model comparison and development
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Merlos, Fernando Aramburu, Silva, João Vasco, Baudron, Frédéric, and Hijmans, Robert J
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Environmental Sciences ,Soil Sciences ,Acid soil ,Exchangeable acidity ,Aluminum saturation ,Base saturation ,pH ,Calcium carbonate equivalent ,Biological Sciences ,Agricultural and Veterinary Sciences ,Agronomy & Agriculture ,Soil sciences - Abstract
Acid tropical soils may become more productive when treated with agricultural lime, but optimal lime rates have yet to be determined in many tropical regions. In these regions, lime rates can be estimated with lime requirement models based on widely available soil data. We reviewed seven of these models and introduced a new model (LiTAS). We evaluated the models' ability to predict the amount of lime needed to reach a target change in soil chemical properties with data from four soil incubation studies covering 31 soil types. Two foundational models, one targeting acidity saturation and the other targeting base saturation, were more accurate than the five models that were derived from them, while the LiTAS model was the most accurate. The models were used to estimate lime requirements for 303 African soil samples. We found large differences in the estimated lime rates depending on the target soil chemical property of the model. Therefore, an important first step in formulating liming recommendations is to clearly identify the soil property of interest and the target value that needs to be reached. While the LiTAS model can be useful for strategic research, more information on acidity-related problems other than aluminum toxicity is needed to comprehensively assess the benefits of liming.
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- 2023
5. Metallothionein-3 is a multifunctional driver that modulates the development of sorafenib-resistant phenotype in hepatocellular carcinoma cells
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Miguel Angel Merlos Rodrigo, Hana Michalkova, Ana Maria Jimenez Jimenez, Frantisek Petrlak, Tomas Do, Ladislav Sivak, Yazan Haddad, Petra Kubickova, Vivian de los Rios, J. Ignacio Casal, Marina Serrano-Macia, Teresa C. Delgado, Loreto Boix, Jordi Bruix, Maria L. Martinez Chantar, Vojtech Adam, and Zbynek Heger
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Metallothionein-3 ,Resistance ,Hepatocellular carcinoma ,Sorafenib ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Background & aims Metallothionein-3 (hMT3) is a structurally unique member of the metallothioneins family of low-mass cysteine-rich proteins. hMT3 has poorly characterized functions, and its importance for hepatocellular carcinoma (HCC) cells has not yet been elucidated. Therefore, we investigated the molecular mechanisms driven by hMT3 with a special emphasis on susceptibility to sorafenib. Methods Intrinsically sorafenib-resistant (BCLC-3) and sensitive (Huh7) cells with or without up-regulated hMT3 were examined using cDNA microarray and methods aimed at mitochondrial flux, oxidative status, cell death, and cell cycle. In addition, in ovo/ex ovo chick chorioallantoic membrane (CAM) assays were conducted to determine a role of hMT3 in resistance to sorafenib and associated cancer hallmarks, such as angiogenesis and metastastic spread. Molecular aspects of hMT3-mediated induction of sorafenib-resistant phenotype were delineated using mass-spectrometry-based proteomics. Results The phenotype of sensitive HCC cells can be remodeled into sorafenib-resistant one via up-regulation of hMT3. hMT3 has a profound effect on mitochondrial respiration, glycolysis, and redox homeostasis. Proteomic analyses revealed a number of hMT3-affected biological pathways, including exocytosis, glycolysis, apoptosis, angiogenesis, and cellular stress, which drive resistance to sorafenib. Conclusions hMT3 acts as a multifunctional driver capable of inducing sorafenib-resistant phenotype of HCC cells. Our data suggest that hMT3 and related pathways could serve as possible druggable targets to improve therapeutic outcomes in patients with sorafenib-resistant HCC.
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- 2024
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6. Estudio comparativo entre maestros y estudiantes de magisterio sobre conocimientos en TDAH
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Ignasi Navarro Soria, Sergio Fernández García, Joshua Collado Valero, Cristina Garrigós Merlos, Eva Mollà Castelló, and Nuria Martínez Boix
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tdah ,funciones ejecutivas ,docentes ,estudiantes ,kadds ,Social Sciences ,Social sciences (General) ,H1-99 - Abstract
El presente estudio analiza los conocimientos de los docentes en activo de educación infantil y primaria y los estudiantes universitarios del Grado de Educación Infantil y Primaria sobre el Trastorno por Déficit de Atención e Hiperactividad (TDAH), y los compara entre sí. En una muestra total de 83 docentes en activo y 109 estudiantes universitarios, se ha implementado la Knowledge of Attention Deficit Hyperactivity Disorder (KADDS) un cuestionario que evalúa tres subescalas de conocimiento sobre el TDAH: Información, Síntomas y Tratamiento. Además, se han añadido ítems sobre el Funcionamiento Ejecutivo. Los resultados indican un pobre conocimiento sobre el TDAH tanto por parte de los docentes en activo como de los estudiantes universitarios, curiosamente, no mostrando diferencias significativas en la comparación general de ambos grupos, pero sí encontrando diferencias significativas en las subescalas individuales de Síntomas y Tratamiento a favor de los estudiantes y a favor de los docentes respectivamente.
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- 2024
7. Hip adduction and abduction strength profiles in elite and sub-elite female soccer players according to players level and leg limb-dominance
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Eloy Jaenada-Carrilero, Juan Vicente-Mampel, Luis Baraja-Vegas, Kristian Thorborg, Eloína Valero-Merlos, Paula Blanco-Gímenez, Pedro Gargallo, and Iker J. Bautista
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Adduction:abduction ratio ,Isometric contractions ,Groin ,Women’s football ,Sports medicine ,RC1200-1245 - Abstract
Abstract Background Understanding the hip adduction and abduction strength in female soccer players is crucial for performance enhancement and injury prevention. This study compares the strength profiles in these muscle groups between elite and sub-elite female soccer players and assesses the impact of leg limb-dominance. Methods A descriptive-comparative study was employed. Eighty-two female soccer players were evaluated. Isometric hip-adduction and abduction strength were measured using a handheld dynamometer. Results Female elite and sub-elite soccer players displayed a mean and standard deviation (SD) on isometric hip-adductor strength for dominant (3.19 Nm/kg ± 0.69 vs. 2.40 Nm/kg ± 0.67) and non-dominant leg (3.32 Nm/kg ± 0.76 versus 2.42 Nm/kg ± 0.70), respectively. For isometric hip-abductor strength in elite and sub-elite players, a mean and SD of dominant (2.86 Nm/kg ± 0.56 vs. 2.07 Nm/kg ± 0.50) and non-dominant (2.80 Nm/kg ± 0.59 vs. 2.04 Nm/kg ± 0.43). In essence, elite players were stronger than sub-elite players on isometric hip-adduction (mean difference [MD] = 0.82 Nm/kg, CI95% = 0.42–1.12) and abduction (MD = 0.83 Nm/kg, CI95% = 0.54- 1.12) both in dominant and non-dominant, leg, whereas no differences existed for hip adduction:abduction ratios between groups and legs. Conclusions Elite female athletes exhibited greater strength than sub-elite female players in both hip adduction and abduction, whereas adduction:abduction ratio values did not differ between the two groups or between different legs.
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- 2024
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8. Periodontopathogens of Periodontal Patients
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Teresa Vinuesa Aumedes, Albert Estrugo Devesa, Felipe Aguilera Muñoz, Ester Fuste Domínguez, Enric Jané Salas, Isabel Martínez Lizán, Sonia Egido Moreno, Carlos Omaña Cepeda, Alexandra Merlos Gil, and José López Lopez, doctor
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- 2023
9. Dietary supplementation with plant extracts for amelioration of persistent myofascial discomfort in the cervical and back regions: a randomized double-blind controlled study
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Silvia Pérez-Piñero, Juan Carlos Muñoz-Carrillo, Jon Echepare-Taberna, Antonio J. Luque-Rubia, Jose Eduardo Millán Rivero, Macarena Muñoz-Cámara, María Josefa Díaz Silvente, Eloina Valero Merlos, Vicente Ávila-Gandía, Nuria Caturla, Pau Navarro, María Cabrera, and Francisco Javier López-Román
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back pain ,rosemary ,ashwagandha ,sesame ,quality of life ,herbal extracts ,Nutrition. Foods and food supply ,TX341-641 - Abstract
BackgroundBack pain is a common health problem that affects both workers and older people, reducing their quality of life. The primary objective was to assess the effect of dietary supplementation with plant extracts of rosemary, ashwagandha, and sesame consumed for 12 weeks on the intensity of back pain.MethodsA single-center randomized double-blind study with three parallel arms depending on the product consumed. The duration of treatment was 12 weeks. The investigational product, Berelief®, contained a blend of three polyphenolic standardized extracts: rosemary (Rosmarinus officinalis L.), ashwagandha (Withania somnifera L.), and sesame (Sesamum indicum L.) seed. Two doses were tested: low dose (400 mg) and high dose (800 mg). There were 42 subjects in the placebo group, 39 in the low dose and 42 in the high dose groups. Study variables included back pain intensity [VAS score, Patient-Reported Outcomes Measurement Information System (PROMIS-29), and Cornell Musculoskeletal Discomfort Questionnaire; functionality Roland-Morris Disability (RMD) questionnaire]; quality of life (QoL) [36-item Short Form Survey (SF-36), the Beck Depression Inventory-II (BDI-II), the State–Trait Anxiety Inventory (STAI), and the Perceived Stress Scale (PSS)]; sleep quality [accelerometer and Pittsburgh Sleep Quality Index (PSQI)].ResultsThe improvement in back pain recorded by the visual analogue scale (VAS) at the study visits after the beginning of treatment, as well as on a weekly basis recorded in the diary card was significantly higher in the intervention group than in the placebo group (p
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- 2024
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10. Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study
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Kasmi, Irena, Drali, Ouardia, Burghart, Sabine, Lakatos-Krepcik, Andrea, Eder, Johannes, Jaksch, Peter, Kainz, Katharina, Kallinger, Margit, Leitner, Alexander, Mozdzen, Marta, Pfleger, Andreas, Renner, Sabine, Stadlinger, Martin, Thir, Christina, Nuriyev, Emil, Boboli, Hedwige, De Wachter, Elke, Dupont, Lieven, Gohy, Sophie, Hanssens, Laurence, Knoop, Christiane, Lammertyn, Elise, Nowé, Vicky, Pirson, Jessica, Thimmesch, Matthieu, Van Braeckel, Eva, Van Hoorenbeeck, Kim, Vanderhelst, Eef, Filho, Eduardo Piacentini, Athanazio, Rodrigo Abensur, Martins, Valéria de Carvalho, Duarte, Marta Cristina, Monte, Luciana de Freitas Velloso, de Fuccio, Marcelo Bicalho, Knabben, Adriana de Siqueira Carvalho, Melloti, Roberta, Meneses, Daniela Gois, Petrova, Guergana, Tješić-Drinković, Duška, Dugac, Andrea Vukić, Bambir, Ivan, Yiallouros, Panayiotis, Bilkova, Alena, Drevinek, Pavel, Macek, Milan, Jr, Olesen, Hanne Vebert, Pressler, Tania, Fouda, Eman Mahmoud, Nasr, Samya, Weldetsadik, Abate Yeshidinber, Al-iede, Montaha, Abdrakhmanov, Olzhas, Corvol, Harriet, Lemonnier-Videau, Lydie, Abely, Michel, Piccini, Carole Bailly, Belleguic, Chantal, Bihouee, Tiphaine, Billon, Yves, Bui, Stéphanie, Camara, Boubou, Cheraud, Marie-Christine, Chiron, Raphael, Duet, Emmanuelle Coirier, Cosson, Laure, Dalphin, Marie-Laure, Boucher, Isabelle Danner, De Miranda, Sandra, Deneuville, Eric, Dubus, Jean-Christophe, Durieu, Isabelle, Epaud, Ralph, Gerardin, Michèle, Grenet, Dominique, Houdouin, Véronique, Huet, Frédéric, Reem, Kanaan, Kessler, Romain, Languepin, Jeanne, Laurans, Muriel, Leroy, Sylvie, Llerena, Cathie, Macey, Julie, Mankikian, Julie, Marguet, Christophe, Martin, Clémence, Mely, Laurent, Mittaine, Marie, Murris-Espin, Marlène, Perisson, Caroline, Prevotat, Anne, Ramel, Sophie, Rames, Cinthia, Reix, Philippe, Revillon, Marine, Reynaud-Gaubert, Martine, Richaud-Thiriez, Bénédicte, Rittie, Jean-Luc, Scalbert-Dujardin, Manuëla, Sermet-Gaudelus, Isabelle, Storni, Véronique, Tatopoulos, Aurélie, Thouvenin, Guillaume, Troussier, Françoise, Weiss, Laurence, Wizla, Nathalie, Behl, Eva-Susanne, Brinkmann, Folke, Claßen, Martin, Graepler-Mainka, Ute, Griese, Matthias, Grübl, Armin, Hammermann, Jutta, Hebestreit, Helge, Heinzmann, Andrea, Herz, Alexander, Kiefer, Alexander, Kinder, Birte, Köster, Holger, Kuhnert, Stefan, Mainz, Jochen, Mayer, Angelika, Naehrig, Susanne, Niehues, Tim, Nüßlein, Thomas, Poplawska, Krystyna, Ringshausen, Felix, Rose, Markus, Rosenecker, Josef, Ruppel, Renate, Scharschinger, Anette, Schropp, Christian, Schwarz, Carsten, Smaczny, Christina, Sommerburg, Olaf, Sutharsan, Sivagurunathan, Stolz, Simone, Thomas, Wolfgang, Wege, Sabine, Welzenbach, Britta, Wollschläger, Bettina, Diamantea, Filia, Hatziagorou, Elpis, Manika, Katerina, Cox, Des, Elnazir, Basil, Fletcher, Godfrey, Gunaratnam, Cedric, McKone, Edward F., Plant, Barry J., Cohen-Cymberknoh, Malena, Gur, Michal, Livnat, Galit, Mei-Zahav, Meir, Amato, Annalisa, Ferrari, Gianluca, Badolato, Raffaele, Poli, Piercarlo, Battistini, Fiorella, Donati, Valentina, Bignamini, Elisabetta, Folino, Anna, Carnovale, Vincenzo, Castellani, Carlo, Casciaro, Rosaria, Cimino, Giuseppe, Cipolli, Marco, Lucca, Francesca, Collura, Mirella, Ficili, Francesca, Daccò, Valeria, Gagliano, Vanessa, Pizzamiglio, Giovanna, Mencarini, Valeria, Palladino, Nicola, Leonardi, Salvatore, Rotolo, Novella, Lucanto, Maria Cristina, Quattromano, Ester, Lucidi, Vincenzina, Majo, Fabio, Alghisi, Federico, Ciciriello, Fabiana, Manca, Antonio, Leonetti, Giuseppina, Maschio, Massimo, Messore, Barbara, Pantano, Stefano, Pisi, Giovanna, Spaggiari, Cinzia, Raia, Valeria, Laezza, Caterina, Ros, Mirco, Salvatore, Donatello, Taccetti, Giovanni, Francalanci, Michela, Vitullo, Pamela, Zolin, Anna, Aleksejeva, Elina, Malakauskas, Kestutis, Misevičiene, Valdone, Charatsi, Anna-Maria, la Barrière, Hélène De, Altenburg, Josje, Bannier, Michiel, Heijerman, Harry, Janssens, Hettie, Koppelman, Gerard, van der Meer, Renske, Merkus, Peter, Nuijsink, Marianne, Terheggen, Suzanne, van der Vaart, Hester, Wesseling, Geert-Jan, de Winter, Karin, Danevska, Ivana Arnaudova, Maretti, Tatjana Jakovska, Fustik, Stojka, Dziecichowicz-Latała, Daria, Wojsyk-Banaszak, Irena, Wozniacki, Lukasz, Amorim, Adelina, Santos, Ana Sofia Araújo, Castanhinha, Susana, Gamboa, Fernanda, Silva, Teresa Reis, Gonçalves, Fabienne, Pereira, Luísa, Ciuca, Ioana, Silva, Sónia, Csilla-Enikö, Szabo, Stan, Iustina, Amelina, Elena, Boitсova, Evgeniya, Chernyavskaya, Anastasia, Gorinova, Yuliya, Krasovskiy, Stanislav, Mukhina, Maria, Sherman, Victoria, Simonova, Olga, Kondratyeva, Elena, Bérešová, Eva, Bližnáková, Nina, Kayserová, Hana, Salobir, Barbara, Šelb, Julij, Krivec, Uroš, Fernandez, Antonio José Aguilar, Fernàndez, Antonio Alvarez, García, Félix Baranda, Aparicio, Marina Blanco, Corullón, Silvia Castillo, Cortell-Aznar, Isidoro, Pérez, Inés, Colomer, Jordi Costa i, Roig, María Cols, Pecellín, Isabel Delgado, Cáceres, Layla Diab, Paredes, Carmen Luna, Gartner, Silvia, Martínez, José Ramón Gutiérrez, Labarga, Inés Herrero, Girón-Moreno, Rosa Maria, Nogueira, Esperanza Jiménez, Ferreiro, Adelaida Lamas, Neyra, Alejandro López, Castro, Enrique Blitz, Galarraga, Laura Moreno, de Vincente, Carlos Martin, Navarro, Silvia Merlos, Nieto-Royo, Rosa, Fuster, Casilda Olveira, Pastor, Maria Dolores, Pérez-Ruiz, Estela, Prados-Sánchez, Concepción, Cancelo, Isabel Ramos, de Valbuena, Marta Ruiz, Asensi, José R. Villa, Santiago, Veronica Sanz, García, Patricia Fernández, Tawfeeq, Reem Mustafa, Banki, Adrienn, Gilljam, Marita, Krantz, Christina, Lindberg, Ulrika, Lindblad, Anders, Clarenbach, Christian, Steinack, Carolin, Hage, René, Schuurmans, Macé, Fischer, Reta, Kusche, Rachel, Rochat, Isabelle, Walter, Anna-Lena, Kamalaporn, Harutai, Hamouda, Samia, Tural, Dilber Ademhan, Ozcelik, Ugur, Asfuroğlu, Pelin, Eyüboğlu, Tuğba Şişmanlar, Aslan, Ayse Tana, Bingöl, Ayşen, Çobanoğlu, Nazan, Ozcan, Gizem, Dogru, Deniz, Gökdemir, Yasemin, KÖSE, Mehmet, Pekcan, Sevgi, Cosgriff, Rebecca, Semenchuk, Julie, Naito, Yumi, Charman, Susan C., Carr, Siobhán B, Cheng, Stephanie Y., Marshall, Bruce C., Faro, Albert, Elbert, Alexander, Gutierrez, Hector H., Goss, Christopher H., Karadag, Bulent, Burgel, Pierre-Régis, Colombo, Carla, Salvatore, Marco, Padoan, Rita, Daneau, Géraldine, Harutyunyan, Satenik, Kashirskaya, Nataliya, Kirwan, Laura, Middleton, Peter G, Ruseckaite, Rasa, de Monestrol, Isabelle, Naehrlich, Lutz, Mondejar-Lopez, Pedro, Jung, Andreas, van Rens, Jacqui, Bakkeheim, Egil, Orenti, Annalisa, Zomer-van Ommen, Domenique, da Silva-Filho, Luiz Vicente RF, Fernandes, Flavia Fonseca, Zampoli, Marco, and Stephenson, Anne L.
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- 2024
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11. Frailty in severe COVID-19 survivors after ICU admission. A prospective and multicenter study in Mexico
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Peñuelas, Oscar, Lomelí, Manuel, del Campo-Albendea, Laura, Toledo, Sara I., Arellano, Alfredo, Chavarría, Uriel, Marín, Maria Carmen, Rosas, Karina, Galván Merlos, María Alacíen, Mercado, Roberto, García-Lerma, Héctor R., Monares, Enrique, González, Daira, Pérez, Juan, Esteban-Fernández, Andrés, Muriel, Alfonso, Frutos-Vivar, Fernando, and Esteban, Andrés
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- 2024
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12. Home Treatment and Perinatal Psychiatry: An Alternative to Acute Psychiatric Wards
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J. Marti Bonany, D. García Hernández, R. Romar Navia, D. Tolosa Merlos, F. Casanovas Martínez, C. Llimona Sánchez, A. Pérez Oms, and G. De Iturbe Catania
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Psychiatry ,RC435-571 - Abstract
Introduction Women experiencing severe perinatal mental health problems require specialized services and care. Perinatal mental disorders are common and can contribute to maternal mortality, affecting neonatal, infant, and child outcomes. Home treatment can prevent hospital admissions and promote strategies within the patient’s support network. Objectives Our aim is to describe a clinical case in perinatal psychiatry managed by a Psychiatric Home Treatment Unit. Methods We present a case of perinatal psychotic depression in a 26-year-old pregnant woman. Results We describe the case of a patient with no prior history of mental health issues. She was 25 weeks pregnant when she first sought psychiatric help in July 2023 and was diagnosed with depressive disorder with psychotic symptoms. She reported symptoms such as low mood, psychomotor inhibition, delusional guilt thoughts, and auditory hallucinations beginning three weeks before her initial visit. Due to her clinical presentation, the patient was admitted to the hospital, where pharmacological treatment was initiated with Olanzapine 5 mg, Sertraline 50 mg, and Lorazepam 1.5 mg. She remained in the hospital for four days, during which she showed gradual improvement but did not achieve full recovery. Considering the improvement observed, home treatment was proposed and accepted by the patient and her relatives. During home treatment, she continued to exhibit persistent depressive and psychotic symptoms, including low mood, inhibition, and delusional thoughts of ruin and catastrophe. Therefore, her treatment was adjusted, with Olanzapine increased to 10 mg, Sertraline raised to 100 mg, and Lorazepam reduced to 0.75 mg. Over time, significant improvement in her clinical symptoms was noted. Throughout the follow-up period, she reported no significant side effects from the pharmacological treatment. After a month of follow-up in our department, she was discharged with outpatient care provided by a specialized community perinatal psychiatric unit. Conclusions We illustrate the possibility of home treatment for perinatal psychiatric disorders. The potential benefits of remaining close to one’s support network and developing coping strategies can be advantageous during the course of illness. Further studies should be conducted to explore these potential benefits. Disclosure of Interest None Declared
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- 2024
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13. Addressing negative symptoms of schizophrenia in a Psychosis Day Hospital: a case report
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F. Mayor Sanabria, E. M. Fernández Fonollosa, C. M. Gil Sánchez, A. Fuentes Merlos, E. X. González Vivero, S. Puyal González, M. Fernández Fariña, and B. Serván Rendon-Luna
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Psychiatry ,RC435-571 - Abstract
Introduction Negative symptoms are present in more than two thirds of schizophrenic patients throughout the evolution of the disorder. These include symptoms related to reduced motivation or pleasure, such as avolition, anhedonia and asociality, and reduced expressivity, including alogia and blunted affect. We present the case of a 24-year-old man who was admitted to our Psychosis Day Hospital after several psychotic episodes, presenting with prominent negative symptomatology that was imbued with mystical delusional beliefs. Objectives 1) To describe the clinical particularities of this case, focusing on the improvement of negative symptoms during the course of treatment at our Day Hospital. 2) To review the available evidence regarding the pharmacological and psychotherapeutic management of negative symptoms of schizophrenia. Methods A review of the patient’s clinical history and complementary tests were carried out. Likewise, we reviewed the available literature in relation to the management of negative symptoms of schizophrenia in an ambulatory setting. Results The patient was admitted to our Day Hospital after four psychiatric hospitalizations due to mystical delusions, ideas of grandiosity and hyper-spirituality, along with prominent negative symptoms at the moment of inclusion at our centre, including social withdrawal, diminished affective response, lack of interest in the academic sphere and poor social drive. Although previous positive symptoms were present in a lesser degree, the patient interpreted the presence of the negative symptoms described above as a “punishment” or “test” from spiritual creatures. Management of negative symptoms represents a major unmet need in schizophrenia. Modest effect size evidence for pharmacological approaches favours the use of antipsychotic in monotherapy and augmentation of antipsychotic treatment with other agents, such as antidepressants. Scarce evidence regarding psychotherapeutic approaches to these symptoms points to the use of cognitive behaviour therapy and social skills training. Conclusions - Clinical identification and characterization of negative symptoms is crucial when treating patients with schizophrenia, as these are associated with important disability and poorer functional outcomes. - Differentiation of primary and secondary negative symptoms is a key aspect in the evaluation and management of schizophrenic patients. - This case outlines the coexistence of positive and negative symptoms, and illustrates the challenges in the pharmacological and psychotherapeutic management of these symptoms at a Psychosis Day Hospital. Disclosure of Interest None Declared
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- 2024
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14. Bipolar disorder, Deafness and Culturality in Psychiatric Home Hospitalization: A Clinical Case
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J. Marti Bonany, G. De Iturbe Catania, R. Romar Navia, D. Tolosa Merlos, C. Montserrat Diez, E. Pechuan Martínez, R. Rodriguez Seoane, L. Gil Martinez, and D. Garcia Hernandez
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Psychiatry ,RC435-571 - Abstract
Introduction Mental health in the deaf community is a complex issue. Challenges in diagnosis and treatment arise from a lack of experienced interpreters and difficulties in translating Sign Language to spoken language. Deaf individuals, due to auditory limitations, are more vulnerable to abuse, increasing their risk of mental health disorders, including bipolar affective disorder (BPAD). BPAD is a prevalent, debilitating condition with varied prevalence estimates. Managing it is tough due to its lifelong, unpredictable nature. A new approach called Psychiatric Home Hospitalization Unit aims to provide acute mental health care at home as an alternative to hospitalization. Objectives To show the management of severe bipolar disorder with comorbidity from a Psychiatric Home Hospitalization Unit Methods A clinical case of bipolar disorder with deafness attended at the Psychiatric Home Hospitalization Unit of our hospital is presented. Results A 24-year-old deaf woman borned in Pakistan and later moving to Catalonia, she faced educational challenges but ultimately completed her studies with sign language support. Afterward, she struggled to find suitable employment, and her family had a history of bipolar disorder. She exhibited a sudden change in behavior, characterized by irritability, paranoia, and distrust. Communication was challenging due to her speech difficulties, but assessments using sign language and observation were conducted. Her physical examination was normal, but her speech was disorganized and pressured, suggesting possible auditory hallucinations and thought disturbances. She was hospitalized and diagnosed with bipolar disorder with psychotic features. During her initial hospitalization, she received lithium, olanzapine, clotiapine and benzodiacepines. After discharge, she continued treatment through a home hospitalization service during almost 4 month. During follow-up she presented a course with high affective instability, rapid cycling alternating brief periods of stability with other presenting manic and mixed features with high disorganization. Due to the rapid cycling pattern Valproic acid was considered. Valproic acid was introduced up to 700 mg/d (97.1 mcg/mL). Treatment with lithium carbonate 800 mg/d (0.91 mEq/L) was maintained. Previous antipsychotic regimen was changed to quetiapine 400mg/d, olanzapine 5mg/d. Her condition improved significantly with the adjusted treatment regimen. She was discharged to an outpatient service. Conclusions Diagnosing and treating bipolar affective disorder (BPAD) in a deaf and mute patient posed unique challenges. The rapid mood cycling pattern and complexity of her case made treatment challenging. Family information and interpreter support were vital. Cultural factors were considered, and home hospitalization was crucial in managing symptoms that lasted over four months. Disclosure of Interest None Declared
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- 2024
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15. Descriptive study of patients admitted to a Psychiatric Home Hospitalization Unit in Santa Coloma de Gramenet and Badalona
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J. Marti Bonany, D. Garcia Hernandez, D. Tolosa Merlos, R. Romar Navia, R. B. Sauras Quetcuti, M. J. Ambros Ghisilieri, G. A. Mateu Codina, D. Garcia Fuentes, A. M. Coratu, G. De Iturbe Catania, R. Sanchez Gonzalez, M. T. Campillo Sanz, and A. Riera Soler
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Psychiatry ,RC435-571 - Abstract
Introduction Hospital at home for psychiatric patients is a new emerging resource of delivering acute mental health care in the community. The main objective of this program is to provide intense care to patients with severe mental disorders at home as an alternative to acute admission. Although home hospitalisation has begun to develop widely in recent years there is a notable lack of studies The CAEM Psychiatric Home Hospitalization Unit (HAD-CAEM) has been operating since 2018 and takes place in Santa Coloma de Gramenet; and from March 2022 also in a part of Badalona. Both are sociodemographically depressed areas near Barcelona. Objectives The aim of this study is to describe the characteristics of patients attended at the Psychiatric Home Hospitalization Unit of our hospital and to study differences according to area and place of referral. Methods Socio-demographic and clinical data were collected retrospectively at admission and discharge of all patients treated at HAD-CAEM between March 2022 to february 2023. Statistical analysis was performed by using SPSS program. Results 85 patients were included in the study. 45.9% were women. The mean age was 45.5 years (SD 15.58 years). The main diagnoses of the sample were psychosis and schizophrenia (38.8%), Bipolar disorder (23.53%), Depressive disorder (21.18%), schizoaffective disorder (8.24%) and others (8,24%). 54 (63.53%) patients were from Santa Coloma area and 35 (41.18%) from Badalona area. The total mean duration of admission was 40.22 days (SD 26.18 days), with a mean follow-up of 10.09 visits (SD 5.39 visits) and 2.41 teleassistence (SD 2.62). The mean duration of admission for Santa Coloma patients was 43.98 days (SD 28.59), and for Badalona patients 33.68 days (SD 20.13). Trend without significance is observed (t= 1.77, p=0.08) We found differences in the mean duration of admission according to referral location. Acute psychiatric unit 33.25 days (SD 18.06), Mental health Center 51.93 days (SD 33.45), Emergencies 34.28 days (SD 19.69) (F=5.1, p=0.008). Conclusions Sociodemografic and clinical característics obtained in our study are consistent with those reported in previous studies. The duration of admission of patients referred from the mental health center is longer than those referred from the acute psychiatric or emergency unit. Home hospitalization teams have been increasing in recent years, being an alternative to traditional hospitalization. Disclosure of Interest None Declared
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- 2024
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16. In vitro models for neuropathic pain phenotypic screening in brain therapeutics
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A.L. Martínez, J. Brea, D. López, N. Cosme, M. Barro, X. Monroy, J. Burgueño, M. Merlos, and M.I. Loza
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Phenotypic screening ,Immortalized cell lines ,In vitro models ,Neuropathic pain ,In vitro pharmacology ,Early drug discovery ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The discovery of brain therapeutics faces a significant challenge due to the low translatability of preclinical results into clinical success. To address this gap, several efforts have been made to obtain more translatable neuronal models for phenotypic screening. These models allow the selection of active compounds without predetermined knowledge of drug targets. In this review, we present an overview of various existing models within the field, examining their strengths and limitations, particularly in the context of neuropathic pain research. We illustrate the usefulness of these models through a comparative review in three crucial areas: i) the development of novel phenotypic screening strategies specifically for neuropathic pain, ii) the validation of the models for both primary and secondary screening assays, and iii) the use of the models in target deconvolution processes.
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- 2024
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17. In vitro models for neuropathic pain phenotypic screening in brain therapeutics
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Martínez, A.L., Brea, J., López, D., Cosme, N., Barro, M., Monroy, X., Burgueño, J., Merlos, M., and Loza, M.I.
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- 2024
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18. Filling the agronomic data gap through a minimum data collection approach
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Tenorio, Fatima A.M., Rattalino Edreira, Juan I., Monzon, Juan Pablo, Aramburu-Merlos, Fernando, Dobermann, Achim, Gruere, Armelle, Brihet, Juan Martin, Gayo, Sofia, Conley, Shawn, Mourtzinis, Spyridon, Mashingaidze, Nester, Sananka, Alex, Aston, Stephen, Ojeda, Jonathan J., and Grassini, Patricio
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- 2024
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19. Cáncer neuroendocrino de mama, presentación de un caso y técnicas diagnósticas
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Merlos-Martínez, María Isabel, Martínez-Díaz, Francisco, and Huelbes-Ros, Alejandro
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- 2023
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20. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events
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Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio
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- 2023
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21. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS eventsResearch in context
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Javier Martínez-Sanz, Jorge Díaz-Álvarez, Marta Rosas, Raquel Ron, José Antonio Iribarren, Enrique Bernal, Félix Gutiérrez, Andrés Ruiz Sancho, Noemi Cabello, Julián Olalla, Santiago Moreno, Sergio Serrano-Villar, Inma Jarrín, David Dalmau, M. Luisa Navarro, M. Isabel González, Federico Garcia, Eva Poveda, Jose Antonio Iribarren, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M. Ángeles Muñoz-Fernández, Inmaculada Jarrín, Cristina Moreno, Marta Rava, Rebeca Izquierdo, Elba Mauleón, Joaquín Portilla, Irene Portilla, Esperanza Merino, Gema García, Iván Agea, José Sánchez-Payá, Juan Carlos Rodríguez, Livia Giner, Sergio Reus, Vicente Boix, Diego Torrus, Verónica Pérez, Julia Portilla, Juan Luís Gómez, Jehovana Hernández, Ana López Lirola, Dácil García, Felicitas Díaz-Flores, M. Mar Alonso, Ricardo Pelazas, M. Remedios Alemán, Víctor Asensi, María Eugenia Rivas Carmenado, Tomás Suarez-Zarracina, Federico Pulido, Otilia Bisbal, M. Asunción Hernando, David Rial, María de Lagarde, Octavio Arce, Adriana Pinto, Laura Bermejo, Mireia Santacreu, Roser Navarro, Candela Gonzalez, M. José Aramburu, Xabier Camino, Miguel Ángel von Wichmann, Miguel Ángel Goenaga, M. Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Xabier Kortajarena, Ignacio Álvarez-Rodriguez, Leire Gil, Lourdes Martínez, Catalina Robledano, Mar Masiá, Sergio Padilla, Araceli Adsuar, Rafael Pascual, Marta Fernández, Antonio Galiana, José Alberto García, Xavier Barber, Vanessa Agullo, Javier Garcia Abellán, Reyes Pascual, Guillermo Telenti, Lucia Guillén, Ángela Botella, Roberto Muga, Arantza Sanvisens, Daniel Fuster, Isabel Gutierrez, Juan Carlos López, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldamiz-Echevarría, Francisco Tejerina, Cristina Diez, Leire Pérez, Chiara Fanciulli, Saray Corral, Anna Martí, Joaquín Peraire, Consuelo Viladés, Montserrat Vargas, Montserrat Olona, Anna Rull, Verónica Alba, Elena Yeregui, Jenifer Masip, Graciano García-Pardo, Frederic Gómez Bertomeu, Sonia Espineira, Marta Montero, Sandra Cuéllar, Marino Blanes, María Tasias, Eva Calabuig, Miguel Salavert, Juan Fernández, Inmaculada Segarra, Juan González-García, Ana Delgado, Francisco Arnalich, José Ramón Arribas, Jose Ignacio Bernardino, Juan Miguel Castro, Luis Escosa, Pedro Herranz, Victor Hontañón, Silvia García-Bujalance, Milagros García, Alicia González-Baeza, M. Luz Martín-Carbonero, Mario Mayoral, M. Jose Mellado, Rafael Esteban, Rocío Montejano, M. Luisa Montes, Victoria Moreno, Ignacio Pérez-Valero, Berta Rodés, Guadalupe Rúa, Talía Sainz, Elena Sendagorta, Eulalia Valencia, Carmen Busca, Joanna Cano, Julen Cardiñanos, Rosa de Miguel, Jose Ramón Blanco, Laura Pérez-Martínez, José Antonio Oteo, Valvanera Ibarra, Luis Metola, Mercedes Sanz, Piedad Arazo, Gloria Sampériz, Marina Martinez, Angels Jaén, Montse Sanmartí, Mireia Cairó, Javier Martinez-Lacasa, Pablo Velli, Roser Font, Mariona Xercavins, Noemí Alonso, Francesco Aiello, María Rivero, Beatriz Piérola, Maider Goikoetxea, María Gracia, Carlos Ibero, Estela Moreno, Jesús Repáraz, Gemma Navarro, Manel Cervantes Garcia, Sonia Calzado Isbert, Marta Navarro Vilasaro, Belen Lopez Garcia, Ignacio de los Santos, Alejandro de los Santos, Jesús Sanz, Lucio García-Fraile, Enrique Martín, Ildefonso Sánchez-Cerrillo, Marta Calvet, Ana Barrios, Azucena Bautista, Carmen Sáez, Marianela Ciudad, Ángela Gutiérrez, Santos del Campo, José Luis Casado, Fernando Dronda, Ana Moreno, M. Jesús Pérez, Sergio Serrano, Ma Jesús Vivancos, Alejandro Vallejo, Matilde Sanchez, Jose Antonio Pérez-Molina, José Manuel Hermida, Antonia Alcaraz, Joaquín Bravo, Ángeles Muñoz, Cristina Tomás, Mónica Martínez, M. Carmen Villalba, Federico García, Clara Martínez, José Hernández, Leopoldo Muñoz Medina, Marta Álvarez, Natalia Chueca, David Vinuesa, Adolfo de Salazar, Ana Fuentes, Emilio Guirao, Laura Viñuela, Andrés Ruiz-Sancho, Francisco Anguita, Jorge Del Romero, Montserrat Raposo, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Begoña Baza, Eva Orviz, Antonio Antela, Elena Losada, Melchor Riera, María Peñaranda, M. Angels Ribas, Antoni A. Campins, Mercedes Garcia-Gazalla, Francisco J. Fanjul, Javier Murillas, Francisco Homar, Helem H. Vilchez, Luisa Martin, Antoni Payeras, Jesús Santos, María López, Crisitina Gómez, Isabel Viciana, Rosario Palacios, Luis Fernando López-Cortés, Nuria Espinosa, Cristina Roca, Silvia Llaves, Juan Manuel Tiraboschi, Arkaitz Imaz, Ana Karina Silva, María Saumoy, Sofía Catalina Scévola, Adrián Curran, Vicenç Falcó, Jordi Navarro, Joaquin Burgos, Paula Suanzes, Jorge García, Vicente Descalzo, Patricia Álvarez, Bibiana Planas, Marta Sanchiz, Lucía Rodríguez, M José Sánchez, Javier Pérez, Alfonso del Arco, Javier de la Torre, José Luis Prada, Onofre Juan Martínez, Lorena Martinez, Francisco Jesús Vera, Josefina García, Begoña Alcaraz, Antonio Jesús Sánchez Guirao, Alvaro Mena, Angeles Castro, Berta Pernas, Pilar Vázquez, Soledad López, Sofía Ibarra, Guillermo García, Josu Mirena, Oscar Luis Ferrero, Josefina López, M. Mar Cámara, Mireia de la Peña, Miriam Lopez, Iñigo Lopez, Itxaso Lombide, Victor Polo, Joana de Miguel, Carlos Galera, Marian Fernández, Helena Albendin, Antonia Castillo, Asunción Iborra, Antonio Moreno, M. Angustias Merlos, Asunción Vidal, Concha Amador, Francisco Pasquau, Concepcion Gil, Jose Tomás Algado, Inés Suarez-García, Eduardo Malmierca, Patricia González-Ruano, M. Pilar Ruiz, José Francisco Pascual, Elena Sáez, Luz Balsalobre, M. Villa López, Mohamed Omar, Carmen Herrero, M. Amparo Gómez, Miguel Alberto de Zarraga, Desiré Pérez, Vicente Estrada, Nieves Sanz, Noemí Cabello, Jorge Vergas García, Maria Jose Núñez, Iñigo Sagastagoitia, Miguel Górgolas, Alfonso Cabello, Beatriz Álvarez, Laura Prieto, Irene Carrillo, José Sanz, Alberto Arranz, Cristina Hernández, María Novella, M. José Galindo, Ana Ferrer, Antonio Rivero Román, Inma Ruíz, Antonio Rivero Juárez, Pedro López, Isabel Machuca, Mario Frias, Ángela Camacho, Ignacio Pérez, Diana Corona, Miguel Cervero, Rafael Torres, Juan Antonio Pineda, Pilar Rincón, Juan Macías, Luis Miguel Real, Anais Corma, Alejandro Gonzalez-Serna, Alexandre Pérez, Luis Morano, Celia Miralles, Antonio Ocampo, Guillermo Pousada, Lucía Patiño, Carlos Dueñas, Sara Gutiérrez, Elena Tapia, Cristina Novoa, Xjoylin Egües, and Pablo Telleria
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HIV ,Non-AIDS events ,Neoplasia ,Cardiovascular event ,CD4/CD8 ratio ,Medicine ,Medicine (General) ,R5-920 - Abstract
Summary: Background: While a low CD4/CD8 ratio during HIV treatment correlates with immunosenescence, its value in identifying patients at an increased risk for clinical events remains unclear. Methods: We analyzed data from the CoRIS cohort to determine whether CD4 count, CD8 count, and CD4/CD8 ratio at year two of antiretroviral therapy (ART) could predict the risk of serious non-AIDS events (SNAEs) during the next five years. These included major adverse cardiovascular events, non-AIDS-defining malignancies, and non-accidental deaths. We used pooled logistic regression with inverse probability weighting to estimate the survival curves and cumulative risk of clinical events. Findings: The study included 4625 participants, 83% male, of whom 200 (4.3%) experienced an SNAE during the follow-up period. A CD4/CD8 ratio
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- 2023
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22. Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids
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Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Javier Burgueño, Xavier Monroy, Bertrand Aubel, Xavier Codony, Luz Romero, Rosalía Pascual, Maria Teresa Serafini, Gregorio Encina, Carmen Almansa, Daniel Zamanillo, Manuel Merlos, and José Miguel Vela
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WLB-73502 ,Sigma-1 receptor ,Mu-opioid receptor ,Biased agonist ,Analgesic activity ,Chronic pain ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Opioids are the most effective painkillers, but their benefit-risk balance often hinder their therapeutic use. WLB-73502 is a dual, bispecific compound that binds sigma-1 (S1R) and mu-opioid (MOR) receptors. WLB-73502 is an antagonist at the S1R. It behaved as a partial MOR agonist at the G-protein pathway and produced no/unsignificant β-arrestin-2 recruitment, thus demonstrating low intrinsic efficacy on MOR at both signalling pathways. Despite its partial MOR agonism, WLB-73502 exerted full antinociceptive efficacy, with potency superior to morphine and similar to oxycodone against nociceptive, inflammatory and osteoarthritis pain, and superior to both morphine and oxycodone against neuropathic pain. WLB-73502 crosses the blood–brain barrier and binds brain S1R and MOR to an extent consistent with its antinociceptive effect. Contrary to morphine and oxycodone, tolerance to its antinociceptive effect did not develop after repeated 4-week administration. Also, contrary to opioid comparators, WLB-73502 did not inhibit gastrointestinal transit or respiratory function in rats at doses inducing full efficacy, and it was devoid of proemetic effect (retching and vomiting) in ferrets at potentially effective doses. WLB-73502 benefits from its bivalent S1R antagonist and partial MOR agonist nature to provide an improved antinociceptive and safety profile respect to strong opioid therapy.
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- 2023
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23. Estimating lime requirements for tropical soils: Model comparison and development
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Aramburu Merlos, Fernando, Silva, João Vasco, Baudron, Frédéric, and Hijmans, Robert J.
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- 2023
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24. BENEFICIOS DE LA TERAPIA ASISTIDA CON PERROS EN EL ÁREA COGNITIVO-CONDUCTUAL DE LOS ADULTOS MAYORES
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PALAZUELOS, PAULA OVEJERO, primary, DÍAZ, MAGDALENA GÓMEZ, additional, PARRA, EVA VEGUE, additional, MERLOS, ELOÍNA VALERO, additional, and MARTÍNEZ, LLANOS MARTÍNEZ, additional
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- 2022
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25. EFECTOS POSITIVOS EN LAS PERSONAS MAYORES AL POSEER UNA MASCOTA
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MERLOS, ELOINA VALERO, primary, MARTÍNEZ, LLANOS MARTÍNEZ, additional, PALAZUELOS, PAULA OVEJERO, additional, DÍAZ, MAGDALENA GÓMEZ, additional, and PARRA, EVA VEGUE, additional
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- 2022
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26. BENEFICIOS DE LA TERAPIA ASISTIDA CON PERROS EN EL ÁREA AFECTIVA DE LOS ADULTOS MAYORES
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DÍAZ, MAGDALENA GÓMEZ, primary, PARRA, EVA VEGUE, additional, MERLOS, ELOÍNA VALERO, additional, MARTÍNEZ, LLANOS MARTÍNEZ, additional, and PALAZUELOS, PAULA OVEJERO, additional
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- 2022
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27. BIENESTAR ANIMAL EN EL PERRO DE INTERVENCIÓN ASISTIDA
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MARTÍNEZ, LLANOS MARTÍNEZ, primary, PALAZUELOS, PAULA OVEJERO, additional, DÍAZ, MAGDALENA GÓMEZ, additional, PARRA, EVA VEGUE, additional, and MERLOS, ELOINA VALERO, additional
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- 2022
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28. APORTES DE LA TERAPIA ASISTIDA CON PERROS A LA ATENCIÓN INTEGRAL DE LAS PERSONAS MAYORES
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PARRA, EVA VEGUE, primary, MERLOS, ELOINA VALERO, additional, MARTÍNEZ, LLANOS MARTÍNEZ, additional, PALAZUELOS, PAULA OVEJERO, additional, and DÍAZ, MAGDALENA GÓMEZ, additional
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- 2022
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29. The burden of acid soils for crop production in sub-Saharan Africa
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Silva, Joao, primary, Aramburu-Merlos, Fernando, additional, Baudron, Frederic, additional, Gameda, Samuel, additional, Sida, Tesfaye, additional, Ruganzu, Vicky, additional, Meliyo, Joel, additional, Jaleta, Moti, additional, Chamberlin, Jordan, additional, and Hijmans, Robert, additional
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- 2024
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30. FRI-466-YI Implications and therapeutic potential of neddylation for pediatric liver cancer: hepatoblastoma
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Zapata-Pavas, Leidy Estefanía, primary, Serrano-Macía, Marina, additional, Rodrigo, Miguel Angel Merlos, additional, Peña-Sanfelix, Patricia, additional, Gil-Pitarch, Claudia, additional, Goikoetxea-Usandizaga, Naroa, additional, Michalkova, Hana, additional, Heger, Zbynek, additional, del Río-Álvarez, Alvaro, additional, Royo, Laura, additional, Rejano-Gordillo, Claudia M., additional, Barrenechea-Barrenechea, Jon Ander, additional, Mercado-Gómez, Maria, additional, Lachiondo-Ortega, Sofia, additional, Delgado, Teresa C., additional, Xirodimas, Dimitris, additional, Marin, Jose J.G., additional, Fernandez-Barrena, Maite G., additional, Avila, Matías A., additional, Armengol, Carolina, additional, and Martínez-Chantar, María Luz, additional
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- 2024
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31. Adopting yield-improving practices to meet maize demand in Sub-Saharan Africa without cropland expansion
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Aramburu-Merlos, Fernando, primary, Tenorio, Fatima A. M., additional, Mashingaidze, Nester, additional, Sananka, Alex, additional, Aston, Stephen, additional, Ojeda, Jonathan J., additional, and Grassini, Patricio, additional
- Published
- 2024
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32. Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition
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Beltrán Álvarez-Pérez, Meritxell Deulofeu, Judit Homs, Manuel Merlos, José Miguel Vela, Enrique Verdú, and Pere Boadas-Vaello
- Subjects
Medicine ,Science - Abstract
Abstract Nociplastic pain arises from altered nociception despite no clear evidence of tissue or somatosensory system damage, and fibromyalgia syndrome can be highlighted as a prototype of this chronic pain subtype. Currently, there is a lack of effective treatments to alleviate both reflexive and nonreflexive pain responses associated with fibromyalgia condition, and suitable preclinical models are needed to assess new pharmacological strategies. In this context, although in recent years some remarkable animal models have been developed to mimic the main characteristics of human fibromyalgia, most of them show pain responses in the short term. Considering the chronicity of this condition, the present work aimed to develop two mouse models showing long-lasting reflexive and nonreflexive pain responses after several reserpine (RIM) or intramuscular acid saline solution (ASI) injections. To our knowledge, this is the first study showing that RIM6 and ASI mouse models show reflexive and nonreflexive responses up to 5–6 weeks, accompanied by either astro- or microgliosis in the spinal cord as pivotal physiopathology processes related to such condition development. In addition, acute treatment with pregabalin resulted in reflexive pain response alleviation in both the RIM6 and ASI models. Consequently, both may be considered suitable experimental models of fibromyalgia-like condition, especially RIM6.
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- 2022
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33. Chick chorioallantoic membrane (CAM) assay for the evaluation of the antitumor and antimetastatic activity of platinum-based drugs in association with the impact on the amino acid metabolism
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Katerina Mitrevska, Miguel Angel Merlos Rodrigo, Natalia Cernei, Hana Michalkova, Zbynek Splichal, David Hynek, Ondrej Zitka, Zbynek Heger, Pavel Kopel, Vojtech Adam, and Vedran Milosavljevic
- Subjects
Platinum nanoparticles ,Cisplatin ,CAM assay ,Breast cancer ,Amino acids metabolism ,TCA cycle ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
The combination of in ovo and ex ovo chorioallantoic membrane (CAM) assay provides an excellent platform which extends its relevance in studying carcinogenesis to the field of screening of anticancer activity of platinum nanoparticles (PtNPs) and further study of the amino acids’ fluctuations in liver and brain. PtNPs are promising candidates for replacing cisplatin (CDDP); however, insufficient data of their antitumor efficiency and activity on the cancer-related amino acid metabolism are available, and the assessment of the in vivo performance has barely scratched the surface. Herein, we used CAM assay as in vivo model for screening of novel therapeutic modalities, and we conducted a comparative study of the effects of CDDP and polyvinylpyrrolidone coated PtNPs on MDA-MB-231 breast cancer xenograft. PtNPs showed a higher efficiency to inhibit the tumor growth and metastasis compared to CDDP. The amino acids profiling in the MDA-MB-231 cells revealed that the PtNPs had an overall depleting effect on the amino acids content. Noteworthy, more side effects to amino acid metabolism were deduced from the depletion of the amino acids in tumor, brain, and liver upon CDDP treatment. Different sets of enzymes of the tricarboxylic acid (TCA) cycle were targeted by PtNPs and CDDP, and while mRNA encoding multiple enzymes was downregulated by PtNPs, the treatment with CDDP affected only two TCA enzymes, indicating a different mechanism of action. Taken together, CAM assay represents and invaluable model, demonstrating the PtNPs capability of repressing angiogenesis, decrease amino acid contents and disrupt the TCA cycle.
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- 2023
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34. Diagnostic difficulties in bipolar disorder type II
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L. Núñez, C. A. del Val, A. F. Merlos, E. X. G. Vivero, C. C. Carrascosa, and M. H. Naval
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Psychiatry ,RC435-571 - Abstract
Introduction Bipolar disorder is one of the top 10 medical causes of disability according to the WHO and despite this, its diagnosis can be delayed up to 10 years after the appearance of the first symptoms of the disease. A major reason for the difficult diagnosis is the challenge of differentiating bipolar disorder type II from unipolar depression and borderline personality disorder, especially in those patients with no clear history of hypomania. Objectives To present a case report of a bipolar disorder undiagnosed for years to remark the importance of recognizing premorbid symptoms of the disease in order to implement an early intervention that potentially improves the prognosis of patients. Methods We compiled the patient’s complete medical history and we carried out a non-systematic review of literature containing the key-words “bipolar disorder type II” and “diagnosis”. Results We present the case of a 48-year-old woman going through a depressive episode, multiple suicide attempts and more than 10 admissions in the Acute Inpatient Psychiatric Unit. For 3 years, the evolution was torpid with a significant multidomain cognitive impairment in a previously functional patient. Different antidepressant treatments were tested, however they were not tolerated due to adverse effects such as anxiety, insomnia and nervousness. After considering multiple differential diagnoses, bipolar disorder type II was finally diagnosed. A hypomanic episode that took place after 3 sessions of electroconvulsive therapy during an admission for depression, allowed to guide the diagnosis and after the introduction of Lithium and Quetiapine as treatment, the patient experienced a complete remission of the symptoms. Conclusions 1. It is important to consider the differential diagnosis of bipolar disorder type II due to its impact on the patient´s life. 2. An early diagnosis improves the course and prognosis of the disease. 3. Patients resistant or intolerant to antidepressant treatment could have undiagnosed bipolar disorder. Disclosure of Interest None Declared
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- 2023
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35. Expectations in the treatment of delusional disorder: A case report
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A. Fuentes Merlos, C. Arroyo del Val, E. X. González Vivero, L. Núñez Cantos, and A. Francos Ajona
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Psychiatry ,RC435-571 - Abstract
Introduction We present the case of a 43 year-old woman that, following the sudden death of his brother in 2015, begins with symptoms of anxiety, irritability and emotional instability, with a tendency to social isolation. Thereafter, she starts the development of persecutory delusions focused on the work and family environment that evolve into inappropriate behaviors to the point of abandoning her professional life. Objectives (1) We will carry out a complete review about persecutory delusions and its relationship with affective disorders, based on the severity of our patient’s case. (2) We will study the different lines of treatment in delusional disorder (DD) and its course and prognosis in relation to the intervention performed. Methods A review of the patient’s history will be conducted, taking into account her biography, clinical evolution and response to the treatments received. Likewise, a bibliographic review of the available scientific literature in relation to DD treatment strategies will be carried out. Results (1) DD is more common in middle-aged women. People who tend to be socially isolated are more likely to develop DD. (2) Acute onset, in young women with identifiable precipitating factors, suggests a better prognosis. (3) In the long term, 50% of patients recover and a further 20% experience some improvement. (4) The combination of antipsychotic medications and psychological therapies such as cognitive behavioral therapy (CBT) is fundamental in the management of DD patients. Conclusions The prognosis for patients with DD varies depending on various factors, including the type and severity of the delusional ideas, and their own life circumstances. It is often possible to eliminate the behavioral alterations derived from the DD, allowing the patient to function normally. However, delusions often persist and become encapsulated. Disclosure of Interest None Declared
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- 2023
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36. POR QUE OS ESTUDANTES DE MEDICINA DEVEM ESTUDAR FILOSOFIA?
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MASSINHAN, B., primary, MERLIN, M. A. R., additional, MERLOS, F., additional, PROSDOCIMO, N. S. N., additional, MERLOS, G. C., additional, GRANDE, I. G., additional, and STREBE, B., additional
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- 2022
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37. Conotoxin-derived biomimetic coiled cone-shaped peptide as ligand for selective nanodelivery to norepinephrine transporter-expressing neuroblastoma cells
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Zivotska, Hana, Mokry, Michal, Rodrigo, Miguel Angel Merlos, Michalkova, Hana, Kapolkova, Katerina, Splichal, Zbynek, Stokowa-Soltys, Kamila, Milosavljevic, Vedran, Guran, Roman, Richtera, Lukas, Haddad, Yazan, Rex, Simona, and Heger, Zbynek
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- 2022
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38. Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition
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Álvarez-Pérez, Beltrán, Deulofeu, Meritxell, Homs, Judit, Merlos, Manuel, Vela, José Miguel, Verdú, Enrique, and Boadas-Vaello, Pere
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- 2022
- Full Text
- View/download PDF
39. Array of individually addressable two-electrode electrochemical cells sharing a single counter/reference electrode for multiplexed enzyme activity measurements
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Gutiérrez-Capitán, Manuel, Baldi, Antoni, Merlos, Ángel, and Fernández-Sánchez, César
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- 2022
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40. A Compact MIMO Rectangular Dielectric Resonator Antenna for Millimeter-Wave Communication.
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Merlos-Garza, Erendira, Khan, Zia U., and Khamas, Salam K.
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DIELECTRIC resonator antennas ,ANTENNA radiation patterns ,ANTENNAS (Electronics) ,MIMO systems ,STATISTICAL correlation - Abstract
A Rectangular Dielectric Resonator Antenna (RDRA) design for mmWave-frequency-band MIMO metrics is proposed, with a compact, low-complexity, high-gain structure that is easy to fabricate and offers reduced inter–port isolation. The RDRA operates in the mmWave spectrum, featuring a compact size of 1.307 λ 0 × 1.307 λ 0 , an impedance bandwidth of 6%, and a resonant frequency of 28 GHz, with a peak gain of 7 dBi. A four element MIMO system iteration was developed while maintaining the performance of the single element antenna. Additionally, a simple, low-complexity slot-etching technique was applied to achieve an average inter-port element isolation of 14 dB. The design also achieved a novel four-beam petal-splitting radiation pattern. The MIMO metrics, with an envelope correlation coefficient (ECC) of <0.5 and a diversity gain (DG) < 10, were successfully met. The simulated and measured results are in good agreement. [ABSTRACT FROM AUTHOR]
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- 2024
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41. Native Pig Neutrophil Products: Insights into Their Antimicrobial Activity
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Eric Fernández-De La Cruz, Joanna Wessely-Szponder, Miguel Viñas, Teresa Vinuesa, Alexandra Merlos, Marta Jorba, Paula Espinal, and Ester Fusté
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antimicrobial peptides ,cathelicidins ,efflux pumps ,black lipid bilayer ,membrane disruption ,atomic force microscopy ,Biology (General) ,QH301-705.5 - Abstract
Cationic antimicrobial peptides are molecules with potential applications for treating infections due to their antimicrobial and immunomodulatory properties. The aim of this work was to explore the antimicrobial activity and mechanisms of action of a porcine neutrophil cathelicidin mixture (MPPN). Gram-positive and Gram-negative bacteria were used to determine the minimum inhibitory concentration (MIC) and experiments of both time–kill kinetics and effects on growth curves were performed. Planar black lipid bilayer conductance was measured to analyze the interaction of MPPN with lipid bilayers. Visualization of bacterial surfaces and membrane alterations was achieved using atomic force microscopy and transmission electron microscopy. The effects on the activity of efflux pumps (EPs) were studied with an intracellular accumulation of acridine orange (AO) assay. In E. coli, MPPN behaves as a bactericide at high concentrations and as a bacteriostatic at lower concentrations. The bacteriostatic effect was also observed for slightly shorter periods in S. enterica. The mixture was not active on S. aureus. The increase in AO accumulation in the presence of MPPN indicates that, at least in E. coli, the mixture causes inhibition of the EP function. Observed and detected variable conductance events demonstrate a strong MPPN effect on lipid bilayers. Damage to the structure of treated E. coli indicates that MPPN induces alterations in the bacterial surface. The use of AMPs capable of inhibiting EP can be seen as a good tool to combat antimicrobial resistance since they could be used alone or in combination with other conventional antibiotics to which bacteria have become resistant.
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- 2023
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42. Effectiveness and Safety of Inhaled Antibiotics in Patients With Chronic Obstructive Pulmonary Disease. A Multicentre Observational Study
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Rolon, Annie Navarro, Wang, Xuejie, Tapia, Alicia Marín, Rubio, Myriam Calle, Asensio, María Jesús Linares, Orbis, Iria Pérez, Olondris, Pilar Martínez, Sanz, Ascensión Hernando, Gafas, Alicia de Pablos, Royo, Margarita Marín, Peris, Selene Cuenca, Fuertes, Julia Amaranta García, Olveira, Casilda, Ramos, Guillermo Bentabol, Bou, Lirios Sacristán, Moreno, Rosa María Girón, Arguedas, Sandra Marín, Zabaleta, Raúl Moreno, Fernández, Sarai Quirós, Sarasate, Mikel, Arranz, María Victoria Leal, Pozas, Gema Castaño de las, Ávila, Nuria Bruguera, Diago, Carlos Antonio Amado, Viteri, Soledad Alonso, Cancelo, María Isabel Ramos, Rivera, Carolina Gotera, Díez, Javier de Miguel, Muñoz, Gemma Sánchez, Zapatero, Esperanza Martín, Celis, Sandra Ros, Navarro, Silvia Merlos, García, Rut Ayerbe, De la Rosa Carrillo, David, Martínez-García, Miguel Ángel, Barreiro, Esther, Tabernero Huguet, Eva, Costa Sola, Roser, García-Clemente, Marta María, Celorrio Jiménez, Nuria, Rodríguez Pons, Laura, Calero Acuña, Carmen, Rodríguez Hermosa, Juan Luís, Golpe, Rafael, Dacal Quintas, Raquel, Sánchez-Cuéllar, Silvia, Torres Arroyo, Irene, Blanco Aparicio, Marina, Almadana Pacheco, Virginia, and Miravitlles, Marc
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- 2022
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43. Healthcare use among people with diabetes mellitus in Europe: a population-based cross-sectional study
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Domingo Orozco-Beltran, Álvaro Fuentes-Merlos, José Antonio Quesada-Rico, and Raul Reina
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Medicine (General) ,R5-920 - Abstract
Objective This study aimed to determine the association of health determinants, lifestyle and socioeconomic variables on healthcare use in people with diabetes in Europe.Design A cross-sectional study was conducted using data from the European Health Interview Survey wave 2 (ie, secondary analysis).Setting The sample included data from 25 European countries.Participants The sample included 16 270 patients with diabetes aged 15 years or older (49.1% men and 50.9% women).Results The survey data showed that 58.2% of respondents had seen their primary care physician in the past month and 22.6% had been admitted to the hospital in the past year. Use of primary care was associated with being retired (prevalence ratio (PR) 1.13, 95% CI 1.07 to 1.19) and having very poor self-perceived health (PR 1.80, 95% CI 1.51 to 2.15), long-standing health problems (PR 1.14, 95% CI 1.04 to 1.24), high blood pressure (PR 1.06, 95% CI 1.03 to 1.10) and chronic back pain (PR 1.07, 95% CI 1.04 to 1.11). Hospital admission was associated with very poor self-perceived health (PR 3.03, 95% CI 2.14 to 4.31), accidents at home (PR 1.54, 95% CI 1.40 to 1.69), chronic obstructive pulmonary disease (COPD) (PR 1.34, 95% CI 1.22 to 1.47), high blood pressure (PR 1.08, 95% CI 1.01 to 1.17), chronic back pain (PR 0.91, 95% CI 0.84 to 0.98), moderate difficulty walking (PR 1.33, 95% CI 1.21 to 1.45) and severe difficulty walking (PR 1.67, 95% CI 1.51 to 1.85).Conclusions In the European diabetic population, the high cumulative incidences of primary care visits and hospital admissions are associated with labour status, alcohol consumption, self-perceived health, long-standing health problems, high blood pressure, chronic back pain, accidents at home, COPD and difficulty walking.
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- 2022
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44. Metallothionein-3 is a multifunctional driver that modulates the development of sorafenib-resistant phenotype in hepatocellular carcinoma cells
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Rodrigo, Miguel Angel Merlos, primary, Michalkova, Hana, additional, Jimenez, Ana Maria Jimenez, additional, Petrlak, Frantisek, additional, Do, Tomas, additional, Sivak, Ladislav, additional, Haddad, Yazan, additional, Kubickova, Petra, additional, de los Rios, Vivian, additional, Casal, J. Ignacio, additional, Serrano-Macia, Marina, additional, Delgado, Teresa C., additional, Boix, Loreto, additional, Bruix, Jordi, additional, Martinez Chantar, Maria L., additional, Adam, Vojtech, additional, and Heger, Zbynek, additional
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- 2024
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45. Author Response: The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19
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Martin-Castaño, Benita, primary, Diez-Echave, Patricia, additional, García-García, Jorge, additional, Hidalgo-García, Laura, additional, Ruiz-Malagon, Antonio Jesús, additional, Molina-Tijeras, José Alberto, additional, Rodríguez-Sojo, María Jesús, additional, Redruello-Romero, Anaïs, additional, Martínez-Zaldívar, Margarita, additional, Mota, Emilio, additional, Cobo, Fernando, additional, Díaz-Villamarin, Xando, additional, Fernández-Varón, Emilio, additional, Alvarez-Estevez, Marta, additional, García, Federico, additional, Morales-García, Concepción, additional, Merlos, Silvia, additional, García-Flores, Paula, additional, Colmenero-Ruiz, Manuel, additional, Ruiz-Sancho, Andrés, additional, Nuñez, María, additional, Rodríguez-Cabezas, María Elena, additional, Carazo, Ángel, additional, Martín, Javier, additional, Morón, Rocío, additional, Rodríguez-Nogales, Alba, additional, and Galvez, Julio, additional
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- 2024
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46. The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19
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Martin-Castaño, Benita, primary, Diez-Echave, Patricia, additional, García-García, Jorge, additional, Hidalgo-García, Laura, additional, Ruiz-Malagon, Antonio Jesús, additional, Molina-Tijeras, José Alberto, additional, Rodríguez-Sojo, María Jesús, additional, Redruello-Romero, Anaïs, additional, Martínez-Zaldívar, Margarita, additional, Mota, Emilio, additional, Cobo, Fernando, additional, Díaz-Villamarin, Xando, additional, Fernández-Varón, Emilio, additional, Alvarez-Estevez, Marta, additional, García, Federico, additional, Morales-García, Concepción, additional, Merlos, Silvia, additional, García-Flores, Paula, additional, Colmenero-Ruiz, Manuel, additional, Ruiz-Sancho, Andrés, additional, Nuñez, María, additional, Rodríguez-Cabezas, María Elena, additional, Carazo, Ángel, additional, Martín, Javier, additional, Morón, Rocío, additional, Rodríguez-Nogales, Alba, additional, and Galvez, Julio, additional
- Published
- 2024
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47. A 2x2 Dual-Band Open Loop Array With Circular Polarisation
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Merlos-Garza, E., primary, Saad, R., additional, and Khamas, S.K., additional
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- 2024
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48. Hip adduction and abduction strength profiles in elite and sub-elite female soccer players according to players level and leg limb-dominance
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Jaenada-Carrilero, Eloy, primary, Vicente-Mampel, Juan, additional, Baraja-Vegas, Luis, additional, Thorborg, Kristian, additional, Valero-Merlos, Eloína, additional, Blanco-Gímenez, Paula, additional, Gargallo, Pedro, additional, and Bautista, Iker J., additional
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- 2024
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49. Educación estética I educación artística. Perspectivas curriculares superpuestas de la enseñanza del arte en la escuela primaria de la provincia de Buenos Aires (1984-1999)
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Merlos, Lucía
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- 2021
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50. Platinum-based drug-induced depletion of amino acids in the kidneys and liver
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Katerina Mitrevska, Natalia Cernei, Hana Michalkova, Migue Angel Merlos Rodrigo, Ladislav Sivak, Zbynek Heger, Ondrej Zitka, Pavel Kopel, Vojtech Adam, and Vedran Milosavljevic
- Subjects
amino acids ,chicken embryo ,platinum nanoparticles ,TCA ,methionine cycle ,toxicity ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Cisplatin (cis-diamminedichloroplatinum II; CDDP) is a widely used cytostatic agent; however, it tends to promote kidney and liver disease, which are a major signs of drug-induced toxicity. Platinum compounds are often presented as alternative therapeutics and subsequently easily dispersed in the environment as contaminants. Due to the major roles of the liver and kidneys in removing toxic materials from the human body, we performed a comparative study of the amino acid profiles in chicken liver and kidneys before and after the application of CDDP and platinum nanoparticles (PtNPs-10 and PtNPs-40). The treatment of the liver with the selected drugs affected different amino acids; however, Leu and Arg were decreased after all treatments. The treatment of the kidneys with CDDP mostly affected Val; PtNPs-10 decreased Val, Ile and Thr; and PtNPs-40 affected only Pro. In addition, we tested the same drugs on two healthy cell lines, HaCaT and HEK-293, and ultimately explored the amino acid profiles in relation to the tricarboxylic acid cycle (TCA) and methionine cycle, which revealed that in both cell lines, there was a general increase in amino acid concentrations associated with changes in the concentrations of the metabolites of these cycles.
- Published
- 2022
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