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Spin-Transfer-Torque (STT) MRAM is configured with high access speed, readily hybrid integration and guaranteed endurance/retention, which becomes one of the most promising candidates for next generation memory. However, the major challenge of STT-MRAM is its high switching energy consumption, accompanied with unreliable writing operation. This work exploits two emerging design paradigms entitled approximation and speculation MRAM. A novel design scheme with timing speculation and approximate storage is proposed to improve energy efficiency in MRAM write operation by reducing write time. Simulation results show that latency and energy loss in entire write operation can be significantly reduced. The proposed technique obtains 84%/57.4% in the symmetric and unidirectional writing operations. Meanwhile, timing speculative method improves the failure/reliability in writing by re-write strategy. Related MRAM macro specification is applied to image processing, which obtains 10% (58.8%-67.2%) of the improvement of precision in image and higher image quality is obtained under the same accuracy rate.

The potato tuber moth, Phthorimaea operculella, is the most damaging potato pest in the world and is difficult to control as the larvae are internal feeders in the foliage and tubers. Entomopathogenic fungi that colonize plants as endophytes have lethal and sublethal pathological effects on insect pests. We show that Beauveria bassiana colonizes the aerial parts of potato plants endophytically after inoculation through soil drenching. Endophytic B. bassiana persisted in potato foliage for more than 50 days postinoculation. Bioassays indicated that foliage of B. bassiana-inoculated potato plants were pathogenic against larvae of P. operculella. Sublethal experiments indicated that B. bassiana negatively affected the growth, development, and reproduction of P. operculella. Development experiments showed that the weight of P. operculella pupae reared on B. bassiana-colonized potato plants (4.25 mg) was significantly less than that of those reared on uninoculated control plants (8.89 mg). Compared with newly eclosed larvae fed on control plants, those fed on B. bassiana-inoculated plants had significantly lower survivorship, with only 17.8% developing to the adult stage. Oviposition of P. operculella females reared on B. bassiana endophytically colonized plants was significantly lower (35 eggs/female) than of those reared on uninoculated plants (115 eggs/female). This study demonstrates that endophytic B. bassiana can be a potential biological control agent for the control and management of P. operculella. Comparing pupal weights of P. operculella reared on potato plants inoculated with the B. bassiana strain GZGY-1-3 and on untreated control plants, pupae from the control plants were significantly heavier than those from treated plants.

A novel Gram-stain-negative, aerobic, non-motile, rod-shaped and orange-colored bacterium, designated as strain C305T, was isolated from marine sediment of the coast area of Weihai, China. Strain C305T growth occurs at 4–40 °C (optimally at 30–33 °C), pH 6.0–9.0 (optimally at pH 8.0) and with 0.5–10.0 % (w/v) NaCl (optimum 1.5–3.0 %). No growth is observed without NaCl. The major cellular fatty acids of strain C305T were identified as iso-C15:0 ，iso-C15:1G and iso-C17:0 3-OH. The major respiratory quinone was found to be MK-6, and the DNA G+C content was determined to be 35.5mol %. The predominant polar lipids were mainly Phosphatidylethanolamines (PE), unidentified aminophospholipids (APL), and a kind of unidentified lipid (L2). Phylogenetic analysis based on 16S rRNA gene sequences revealed that C305T was a member of the genus Brumimicrobium and had a 16S rRNA gene sequence similarity values of 96.9–98.0 % with recognized Brumimicrobium species. On the basis of the phylogentic and phenotypic evidences, strain C305T represents a novel species of the genus Brumimicrobium, for which the name Brumimicrobium oceani sp. nov. is proposed. The type strain is C305T (= KCTC 62371T =MCCC 1H00297T).

A Gram-stain-negative, rod-shaped, glide, non-flagellated, and facultatively aerobic bacterial strain, designated as Z654T, was isolated from the gut of abalone Haliotis discus hannai from Rongcheng, Shandong province, China. Cells are 0.2–0.8 µm in width and 0.7–3.4 µm in length. Cells grew best at 30°C (range, 15–37°C), pH 7 (range, 6.0–8.5) and NaCl concentration of 2.0% (w/v) (range, 1–10%). According to the phylogenetic analysis of 16S rRNA gene sequence, the strain belongs to the genus Halocynthiibacter and the most close strain is Halocynthiibacter arcticus KCTC 42129T (97.12%). The genome size of strain Z654T was 3296250 bp and the DNA G + C content was 54.2 mol%. The average nucleotide identity (ANI) scores and digital DNA–DNA hybridization (dDDH) scores with H. arcticus KCTC 42129T was 70% and 14.6–18.2% respectively. The predominant quinone was Q-10 and the major fatty acids were C18:0, C18:1 ω7c 11-methyl and summed future 8. The polar lipids were consisted of phosphatidylcholine, phosphatidylglycerol, unidentified aminolipid and unidentifed lipids. Based on the phenotypic, phylogenetic and chemotaxonomic data, strain Z654T was considered to represent a novel species of the genus Halocynthiibacter, for which the name Halocynthiibacte halioticoli sp. nov., is proposed. The type strain is Z654T (= MCCC 1H00503T = KCTC 92003T).

Background Lung cancer is one of the most commonly diagnosed malignancies worldwide, and the occurrence of venous thrombosis in combination with lung cancer seriously affects the survival prognosis of patients with lung cancer. This study aimed to delineate the publication status and trends in the literature related to thrombosis in lung cancer and to explore hotspots in research by conducting a bibliometric analysis. Methods Using the Web of Science database as the data source for bibliometric analysis, we searched the published research literature related to thrombosis in lung cancer from 1942 to 2022. Bibliometrix and VOSviewer were used to analyze key bibliometric indicators, including trends in the number of annual publications, countries, journals, author contributions, and research hotspots. Results A total of 378 papers related to thrombosis in lung cancer were screened, including 349 original articles and 29 reviews. The number of publications has increased rapidly in the last 20 years, and China and the United States have the largest number of publications. In the analysis of authors and journals, we found that the distribution of Chinese authors is relatively high in terms of the number of publications and their influence, while the journal sources are mainly dominated by oncology and thrombosis research journals. The analysis of the top 10 highly cited papers revealed that several studies involved the relationship between cancer and venous thrombosis and the exploration of cancer-related thrombotic risk factors. The keyword analysis showed that the papers mainly focused on the exploration of risk factors, in which related genes represented by ROS1 and immunotherapy gradually appeared in research on predicting thrombosis in lung cancer. Conclusions Research on thrombosis in lung cancer has developed rapidly in the past 20 years, with the largest number of studies coming from China. The main research hotspots are the exploration of risk factors, among which the association between related genes represented by ROS1, immunotherapy, and thrombosis in lung cancer-related events has brought us new thinking in the prevention of thrombosis in lung cancer.

Purpose Drawing on the resource-based view (RBV) and structure–conduct–performance (SCP) paradigm perspectives, this study aims to investigate the influence of the innovation and technical capabilities of exporting organisations on their export performance moderate by competitive intensity. Design/methodology/approach Primary data were collected from 162 Chinese manufacturer–exporter companies operating across China. The conceptual framework of this study, which incorporated the impact of RBV and SCP paradigm determinants on export performance through the interaction effect of competitive intensity, was tested using structural equation modelling (Smart-PLS). Findings Results show that the technical and innovation capabilities can increase its export success in international markets. Furthermore, this research finds that competitive intensity moderates the positive relationship between technical capability and export performance but not the relationship between innovation capability and export performance. Originality/value This study presents a holistic assessment of the export performance of manufacturer–exporter enterprises by accounting for the overlooked effect of organisational capabilities through the moderating function of competitive intensity. This study has far-reaching consequences for export academics and practitioners, including the fundamental concept of an internationalizing small- and medium-sized enterprises, especially the manufacturers.

A Gram-stain-negative, rod-shaped, glide, non-flagellated, and facultatively aerobic bacterial strain, designated as Z654T, was isolated from the gut of abalone Haliotis discus hannai from Rongcheng, Shandong province, China. Cells are 0.2–0.8 µm in width and 0.7–3.4 µm in length. Cells grew best at 30°C (range, 15–37°C), pH 7 (range, 6.0–8.5) and NaCl concentration of 2.0% (w/v) (range, 1–10%). According to the phylogenetic analysis of 16S rRNA gene sequence, the strain belongs to the genus Halocynthiibacter and the most close strain is Halocynthiibacter arcticus KCTC 42129T (97.12%). The genome size of strain Z654T was 3296250 bp and the DNA G + C content was 54.2 mol%. The average nucleotide identity (ANI) scores and digital DNA–DNA hybridization (dDDH) scores with H. arcticus KCTC 42129T was 70% and 14.6–18.2% respectively. The predominant quinone was Q-10 and the major fatty acids were C18:0, C18:1 ω7c 11-methyl and summed future 8. The polar lipids were consisted of phosphatidylcholine, phosphatidylglycerol, unidentified aminolipid and unidentifed lipids. Based on the phenotypic, phylogenetic and chemotaxonomic data, strain Z654T was considered to represent a novel species of the genus Halocynthiibacter, for which the name Halocynthiibacte halioticoli sp. nov., is proposed. The type strain is Z654T (= MCCC 1H00503T = KCTC 92003T).

Psoriasis is a type of chronic autoimmune-mediated inflammatory skin condition in which clinical manifestations are characterized by erythema and scaly changes, with complex pathogenesis and ease of relapse, and it is difficult to cure. Lenalidomide (Len) is a structural analog of thalidomide, which belongs to the second generation of immunomodulators and has the functions of tumor killing, immune regulation, anti-angiogenesis and regulation of the myeloma microenvironment. In the current experiment, we investigated the therapeutic effect of transdermal application of Len on the pathological changes of imiquimod (IMQ)-induced skin irritations and inflammation in psoriatic-like mice. The in vivo results revealed that Len nanoemulsion-based gels markedly reduced the IMQ-induced Psoriasis Area Severity Index (PASI) score, spleen-to-body weight index and CD4 protein expression in the derma of mice and improved IMQ-induced skin inflammatory cell infiltration. Transcriptome sequencing was intended to obtain the differentially expressed genes among the skin of Con mice and the skin of IMQ mice, and then, the GO enrichment classification and KEGG pathway analysis of the significant genes was executed to obtain major signaling pathways in the pathogenesis of the psoriasis mouse model. It was found that the PI3K/AKT signaling pathway was a major pathway in the pathogenesis of psoriasis in a mouse model induced by IMQ. The immunohistochemical results confirmed that Len could modulate the protein expression of AKT and NF-κB in skin. In conclusion, the protective effect of transdermal administration of Len may be related to the inhibition of the PI3K/AKT signaling pathway and its downstream NF-κB pathway against IMQ-induced psoriasis in mice.

Six Cd(II)/Mn(II)/Co(II)/Ni(II)/Zn(II) coordination complexes are formulated as [Cd2(X2−)2(μ3-O)2/3]n (1), [Mn2(X2−)2(μ3-O)2/3]n (2), {[Co1.5(Y4−)0.5(4,4′-bpy)1.5(OH−)]·2H2O}n (3), {[Ni(X2−)(4,4′-bpy)(H2O)2]·4H2O}n (4), [Zn(m-bdc2−)(bebiyh)]n (5), and [Cd(5-tbia2−)(bebiyh)]n (6) (H2X = 3,3′-(2,3,5,6-tetramethyl-1,4-phenylene) dipropionic acid. H4Y = 2,2′-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene) dimalonic acid, bebiyh = 1,6-bis(2-ethyl-1H-benzo[d]imidazol-1-yl)hexane, m-H2bdc = 1,3-benzenedicarboxylic acid, and 5-H2tbia = 5-(tert-butyl)isophthalic acid) were obtained by hydrothermal reactions and structurally characterized. Complexes 1 and 2 have a 6-connected 3D architecture and with several point symbols of (36·46·53). Complex 3 features a 5-connected 3D net structure with a point symbol of (5·69). Complex 4 possesses a 4-connected 2D net with a vertex symbol of (44·62). Complex 5 is a 3-connected 2D network with a point symbol of (63). Complex 6 is a (3,3)-connected 2D network with a point symbol of (63)2. In addition, complexes 1 and 4 present good photoluminescence behaviors. The electronic structures of 1 and 4 were investigated with the density functional theory (DFT) method to understand the photoluminescence behaviors.