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Researchers from the University of Michigan Health Rogel Cancer Center have developed a urine-based test that can detect head and neck cancer. The test utilizes DNA fragments released by tumor cells, which are passed into urine through the kidneys. These fragments are ultra-short, making them difficult to detect using conventional urine or blood-based tests. The test has already been distributed for research purposes and has shown promising results in detecting cancer recurrences earlier than clinical imaging. Additionally, the test has the potential to be expanded to detect other types of cancer. [Extracted from the article]

Researchers at the University of Michigan have reported new findings on the detection of oropharyngeal cancer. The study focused on the use of transrenal cell-free tumor DNA (TR-ctDNA) found in urine as a noninvasive method for cancer detection. The researchers discovered that the DNA fragments in urine are predominantly ultrashort, which may be missed by conventional ctDNA assays. The study suggests that focusing on these ultrashort fragments of TR-ctDNA could improve urine-based cancer diagnostics and facilitate at-home specimen collections. [Extracted from the article]