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1. Design and rationale of the CLEAR SYNERGY (OASIS 9) trial: A 2x2 factorial randomized controlled trial of colchicine versus placebo and spironolactone vs placebo in patients with myocardial infarction

Author

d'Entremont, Marc-André, Lee, Shun Fu, Mian, Rajibul, Kedev, Sasko, Montalescot, Gilles, Cornel, Jan Hein, Stankovic, Goran, Moreno, Raul, Storey, Robert F., Henry, Timothy D., Skuriat, Elizabeth, Tyrwhitt, Jessica, Mehta, Shamir R., Devereaux, P.J., Eikelboom, John, Cairns, John A., Pitt, Bertram, and Jolly, Sanjit S.

Published
2024
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3. SYNERGY—Everolimus-Eluting Stent With a Bioabsorbable Polymer in ST-Elevation Myocardial Infarction: CLEAR SYNERGY OASIS-9 Registry

Author

Jolly, Sanjit S., Lee, Shun Fu, Mian, Rajibul, Kedev, Sasko, Lavi, Shahar, Moreno, Raul, Montalescot, Gilles, Hillani, Ali, Henry, Timothy D., Asani, Valon, Storey, Robert F., Silvain, Johanne, Spratt, James C.S., d'Entremont, Marc-André, Stankovic, Goran, Zafirovska, Biljana, Natarajan, Madhu K., Sabate, Manel, Shreenivas, Satya, Pinilla-Echeverri, Natalia, Sheth, Tej, Altisent, Omar Abdul-Jawad, Ribas, Núria, Skuriat, Elizabeth, Tyrwhitt, Jessica, and Mehta, Shamir R.

Published
2024
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4. Ticagrelor with or without aspirin following percutaneous coronary intervention in high-risk patients with concomitant peripheral artery disease: A subgroup analysis of the TWILIGHT randomized clinical trial

Author

Krucoff, Mitchell, Spirito, Alessandro, Baber, Usman, Sartori, Samantha, Angiolillo, Dominick J., Briguori, Carlo, Cohen, David J., Collier, Timothy, Dangas, George, Dudek, Dariusz, Escaned, Javier, Gibson, C. Michael, Han, Ya-Ling, Huber, Kurt, Kastrati, Adnan, Kaul, Upendra, Kornowski, Ran, Kunadian, Vijay, Vogel, Birgit, Mehta, Shamir R., Moliterno, David, Sardella, Gennaro, Shlofmitz, Richard A., Sharma, Samin, Steg, Philippe Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2024
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5. Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology 2023 Focused Update of the Guidelines for the Use of Antiplatelet Therapy

Author

Bainey, Kevin R., Marquis-Gravel, Guillaume, Belley-Côté, Emilie, Turgeon, Ricky D., Ackman, Margaret L., Babadagli, Hazal E., Bewick, David, Boivin-Proulx, Laurie-Anne, Cantor, Warren J., Fremes, Stephen E., Graham, Michelle M., Lordkipanidzé, Marie, Madan, Mina, Mansour, Samer, Mehta, Shamir R., Potter, Brian J., Shavadia, Jay, So, Derek F., Tanguay, Jean-François, Welsh, Robert C., Yan, Andrew T., Bagai, Akshay, Bagur, Rodrigo, Bucci, Claudia, Elbarouni, Basem, Geller, Carol, Lavoie, Andrea, Lawler, Patrick, Liu, Shuangbo, Mancini, John, and Wong, Graham C.

Published
2024
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6. Effects of complete revascularization according to age in patients with ST-segment elevation myocardial infarction and multivessel disease (COMPLETE-AGE)

Author

Bainey, Kevin R., Wood, David A., Bossard, Matthias, Campo, Gianluca, Cantor, Warren J., Lavi, Shahar, Madan, Mina, Mehran, Roxana, Pinilla-Echeverri, Natalia, Rao, Sunil, Sarma, Jaydeep, Sheth, Tej, Stankovic, Goran, Steg, Phillipe Gabriel, Storey, Robert F., Tanguay, Jean-Francois, Velianou, James L., Welsh, Robert C., Mani, Thenmozhi, Cairns, John A., and Mehta, Shamir R.

Published
2024
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7. Clinically Driven Revascularization in High-Risk Patients Treated With Ticagrelor Monotherapy After PCI: Insights from the Randomized TWILIGHT Trial

Author

Baber, Usman, Spirito, Alessandro, Sartori, Samantha, Angiolillo, Dominick J., Briguori, Carlo, Cohen, David J., Collier, Timothy, Dangas, George, Dudek, Dariusz, Escaned, Javier, Gibson, C. Michael, Han, Ya-Ling, Huber, Kurt, Kastrati, Adnan, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell, Kunadian, Vijay, Vogel, Birgit, Mehta, Shamir R., Moliterno, David, Sardella, Gennaro, Shlofmitz, Richard A., Sharma, Samin, Steg, Philippe Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2023
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9. Biolimus-eluting vs. other limus-eluting stents in NSTE-ACS: A pooled analysis of GLASSY and TWILIGHT

Author

Spirito, Alessandro, Valgimigli, Marco, Cao, Davide, Baber, Usman, Mehta, Shamir R., Gibson, C. Michael, Steg, Gabriel P., Sharma, Samin K., Goel, Ridhima, Huber, Kurt, Kunadian, Vijay, Escaned, Javier, Franzone, Anna, Yaling, Han, Collier, Timothy, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell, Moliterno, David, Sartori, Samantha, Owen, Ruth, Zhang, Zhongjie, Dangas, George D., Kastrati, Adnan, Angiolillo, Dominick J., Cohen, David J., Vranckx, Pascal, Windecker, Stephan, Pocock, Stuart, and Mehran, Roxana

Published
2023
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11. External applicability of the Effect of ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) trial: An analysis of patients with diabetes and coronary artery disease in the REduction of Atherothrombosis for Continued Health (REACH) registry

Author

Abtan, Jeremie, Bhatt, Deepak L., Elbez, Yedid, Ducrocq, Gregory, Goto, Shinya, Smith, Sidney C., Jr, Ohman, E. Magnus, Eagle, Kim A., Fox, Kim, Harrington, Robert A., Leiter, Lawrence A., Mehta, Shamir R., Simon, Tabassome, Petrov, Ivo, Sinnaeve, Peter R., Pais, Prem, Lev, Eli, Bueno, Héctor, Wilson, Peter, and Steg, Philippe Gabriel

Published
2023
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12. Use and outcomes of dual antiplatelet therapy for acute coronary syndrome in patients with chronic kidney disease: insights from the Canadian Observational Antiplatelet Study (COAPT)

Author

Graham, Carol Anne, Tan, Mary K., Chew, Derek P., Gale, Christopher P., Fox, Keith A. A., Bagai, Akshay, Henderson, Mark A., Quraishi, Ata ur Rehman, Déry, Jean-Pierre, Cheema, Asim N., Fisher, Harold, Brieger, David, Lutchmedial, Sohrab R., Lavi, Shahar, Wong, Brian Y. L., Cieza, Tomas, Mehta, Shamir R., Brass, Neil, Goodman, Shaun G., and Yan, Andrew T.

Published
2022
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13. Complete Revascularization Versus Culprit-Lesion-Only PCI in STEMI Patients With Diabetes and Multivessel Coronary Artery Disease: Results From the COMPLETE Trial

Author

Oqab, Zardasht, Kunadian, Vijay, Wood, David A., Storey, Robert F., Rao, Sunil V., Mehran, Roxana, Pinilla-Echeverri, Natalia, Mani, Thenmozhi, Boone, Robert H., Kassam, Saleem, Bossard, Matthias, Mansour, Samer, Ball, Warren, Sibbald, Matthew, Valettas, Nicholas, Moreno, Raul, Steg, Philippe Gabriel, Cairns, John A., and Mehta, Shamir R.

Published
2023
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16. Balance of benefit and risk of ticagrelor in patients with diabetes and stable coronary artery disease according to bleeding risk assessment with the CRUSADE score: Data from THEMIS and THEMIS PCI

Author

Ducrocq, Gregory, Bhatt, Deepak L., Lee, Jane J., Kui, Naishu, Fox, Kim M., Harrington, Robert A., Leiter, Lawrence A., Mehta, Shamir R., Kiss, Róbert Gábor, James, Stefan, Vinereanu, Dragos, Huber, Kurt, Andersson, Marielle, Himmelmann, Anders, Simon, Tabassome, and Steg, Ph. Gabriel

Published
2022
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18. Demystifying the Contemporary Role of 12-Month Dual Antiplatelet Therapy After Acute Coronary Syndrome.

Author

Valgimigli, Marco, Landi, Antonio, Angiolillo, Dominick J., Baber, Usman, Bhatt, Deepak L., Bonaca, Marc P., Capodanno, Davide, Cohen, David J., Gibson, C. Michael, James, Stefan, Takeshi Kimura, Lopes, Renato D., Mehta, Shamir R., Montalescot, Gilles, Sibbing, Dirk, Steg, P. Gabriel, Stone, Gregg W., Storey, Robert F., Vranckx, Pascal, and Windecker, Stephan

Published
2024
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21. 2023 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy

Author

Bainey, Kevin R., primary, Marquis-Gravel, Guillaume, additional, Belley-Côté, Emilie, additional, Turgeon, Ricky D., additional, Ackman, Margaret L., additional, Babadagli, Hazal E., additional, Bewick, David, additional, Boivin-Proulx, Laurie-Anne, additional, Cantor, Warren J., additional, Fremes, Stephen E., additional, Graham, Michelle M., additional, Lordkipanidzé, Marie, additional, Madan, Mina, additional, Mansour, Samer, additional, Mehta, Shamir R., additional, Potter, Brian J., additional, Shavadia, Jay, additional, So, Derek F., additional, Tanguay, Jean-François, additional, Welsh, Robert C., additional, Yan, Andrew T., additional, Bagai, Akshay, additional, Bagur, Rodrigo, additional, Bucci, Claudia, additional, Elbarouni, Basem, additional, Geller, Carol, additional, Lavoie, Andrea, additional, Lawler, Patrick, additional, Liu, Shuangbo, additional, Mancini, John, additional, and Wong, Graham C., additional

Published
2023
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23. No-reflow after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction: an angiographic core laboratory analysis of the TOTAL Trial

Author

d'Entremont, Marc-André, primary, Alazzoni, Ashraf, additional, Dzavik, Vladimir, additional, Sharma, Vinoda, additional, Overgaard, Christopher B., additional, Lemaire-Paquette, Samuel, additional, Lamelas, Pablo, additional, Cairns, John A., additional, Mehta, Shamir R., additional, Natarajan, Madhu K., additional, Sheth, Tej N., additional, Schwalm, John-David, additional, Rao, Sunil V., additional, Stankovic, Goran, additional, Kedev, Sasko, additional, Moreno, Raul, additional, Cantor, Warren J., additional, Lavi, Shahar, additional, Bertrand, Olivier F., additional, Nguyen, Michel, additional, Couture, Étienne L., additional, and Jolly, Sanjit S., additional

Published
2023
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24. Ultrasound-Guided Femoral Access in Patients With Vascular Closure Devices: Insights From the Randomized UNIVERSAL Trial

Author

d'Entremont, Marc-André, primary, Alrashidi, Sulaiman, additional, Alansari, Omar, additional, Brochu, Bradley, additional, Heenan, Laura, additional, Skuriat, Elizabeth, additional, Tyrwhitt, Jessica, additional, Raco, Micheal, additional, Tsang, Micheal, additional, Valettas, Nicholas, additional, Velianou, James, additional, Sheth, Tej, additional, Sibbald, Matthew, additional, Mehta, Shamir R., additional, Pinilla-Echeverri, Natalia, additional, Schwalm, Jon David, additional, Natarajan, Madhu K., additional, Akl, Elie, additional, Tawadros, Sarah, additional, Camargo, Mercedes, additional, Bauer, John, additional, Moxham, Rachel, additional, Dutra, Gustavo, additional, Winter, Jose, additional, and Jolly, Sanjit S., additional

Published
2023
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26. Ultrasound-guided femoral access in patients with vascular closure devices: a prespecified analysis of the randomised UNIVERSAL trial

Author

d'Entremont, Marc-André, primary, Alrashidi, Sulaiman, additional, Alansari, Omar, additional, Brochu, Bradley, additional, Heenan, Laura, additional, Skuriat, Elizabeth, additional, Tyrwhitt, Jessica, additional, Raco, Micheal, additional, Tsang, Micheal, additional, Valettas, Nicholas, additional, Velianou, James L., additional, Sheth, Tej N., additional, Sibbald, Matthew, additional, Mehta, Shamir R., additional, Pinilla-Echeverri, Natalia, additional, Schwalm, Jon David, additional, Natarajan, Madhu K., additional, Kelly, Andrew, additional, Akl, Elie, additional, Tawadros, Sarah, additional, Camargo, Mercedes, additional, Faidi, Walaa, additional, Bauer, John, additional, Moxham, Rachel, additional, Nkurunziza, James, additional, Dutra, Gustavo, additional, Winter, Jose, additional, and Jolly, Sanjit S., additional

Published
2023
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27. Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure

Author

Borlaug, Barry A., Blair, John, Bergmann, Martin W., Bugger, Heiko, Burkhoff, Dan, Bruch, Leonhard, Celermajer, David S., Claggett, Brian, Cleland, John G. F., Cutlip, Donald E., Dauber, Ira, Eicher, Jean-Christophe, Gao, Qi, Gorter, Thomas M., Gustafsson, Finn, Hayward, Chris, Van der Heyden, Jan, Hasenfuß, Gerd, Hummel, Scott L., Kaye, David M., Komtebedde, Jan, Massaro, Joseph M., Mazurek, Jeremy A., McKenzie, Scott, Mehta, Shamir R., Petrie, Mark C., Post, Marco C., Nair, Ajith, Rieth, Andreas, Silvestry, Frank E., Solomon, Scott D., Trochu, Jean-Noël, Veldhuisen, Dirk J. Van, Westenfeld, Ralf, Leon, Martin B., Shah, Sanjiv J., and Cardiovascular Centre (CVC)

Subjects
Male, Cardiac Catheterization, Pulmonary Circulation, hypertension, pulmonary, hypertension, pulmonary, heart failure, EXERCISE, PRESSURE, Article, Physiology (medical), therapeutics, Humans, Heart Atria, lung diseases, OUTCOMES, REST, Stroke Volume, clinical trial, TIME, Treatment Outcome, PRESERVED EJECTION FRACTION, Female, vascular diseases, Cardiology and Cardiovascular Medicine, INTERATRIAL SHUNT
Abstract

Background: In REDUCE LAP-HF II (A Study to Evaluate the Corvia Medical, Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients With Heart Failure), implantation of an atrial shunt device did not provide overall clinical benefit for patients with heart failure with preserved or mildly reduced ejection fraction. However, prespecified analyses identified differences in response in subgroups defined by pulmonary artery systolic pressure during submaximal exercise, right atrial volume, and sex. Shunt implantation reduces left atrial pressures but increases pulmonary blood flow, which may be poorly tolerated in patients with pulmonary vascular disease (PVD). On the basis of these results, we hypothesized that patients with latent PVD, defined as elevated pulmonary vascular resistance during exercise, might be harmed by shunt implantation, and conversely that patients without PVD might benefit. Methods: REDUCE LAP-HF II enrolled 626 patients with heart failure, ejection fraction ≥40%, exercise pulmonary capillary wedge pressure ≥25 mm Hg, and resting pulmonary vascular resistance Results: Compared with patients without PVD (n=382), those with latent PVD (n=188) were older, had more atrial fibrillation and right heart dysfunction, and were more likely to have elevated left atrial pressure at rest. Shunt treatment was associated with worse outcomes in patients with PVD (win ratio, 0.60 [95% CI, 0.42, 0.86]; P =0.005) and signal of clinical benefit in patients without PVD (win ratio, 1.31 [95% CI, 1.02, 1.68]; P =0.038). Patients with larger right atrial volumes and men had worse outcomes with the device and both groups were more likely to have pacemakers, heart failure with mildly reduced ejection fraction, and increased left atrial volume. For patients without latent PVD or pacemaker (n=313; 50% of randomized patients), shunt treatment resulted in more robust signal of clinical benefit (win ratio, 1.51 [95% CI, 1.14, 2.00]; P =0.004). Conclusions: In patients with heart failure with preserved or mildly reduced ejection fraction, the presence of latent PVD uncovered by invasive hemodynamic exercise testing identifies patients who may worsen with atrial shunt therapy, whereas those without latent PVD may benefit.

Published
2022

28. PREVALENCE AND IMPACT OF ANGINA IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE AND DIABETES. INSIGHTS FROM THE THEMIS TRIAL

Author

Mesnier, Jules, primary, Bhatt, Deepak L., additional, Zheng, Luke, additional, Fox, Kim Michael, additional, Harrington, Robert A., additional, Leiter, Lawrence A., additional, Mehta, Shamir R., additional, Simon, Tabassome, additional, Andersson, Marielle, additional, Himmelmann, Anders, additional, and Steg, Philippe Gabriel, additional

Published
2023
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29. Clinical Significance of Culprit Vessel Occlusion in Patients With Non–ST-Elevation Myocardial Infarction Who Underwent Percutaneous Coronary Intervention

Author

Popovic, Batric, primary, Ducrocq, Gregory, additional, Elbez, Yedid, additional, Bode, Christoph, additional, Mehta, Shamir. R., additional, Pollack, Charles V., additional, Sabate, Manel, additional, Rao, Sunil V., additional, Parkhomenko, Alexander, additional, Feldman, Laurent J., additional, Sayah, Neila, additional, Sabatine, Marc S., additional, and Steg, Philippe Gabriel, additional

Published
2023
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30. CRT-100.01 Ultrasound-Guided Femoral Access in Patients With Vascular Closure Devices: Insights From the Randomized UNIVERSAL Trial

Author

d'Entremont, Marc-André, primary, Alrashidi, Sulaiman, additional, Alansari, Omar, additional, Brochu, Bradley, additional, Heenan, Laura, additional, Skuriat, Elizabeth, additional, Tyrwhitt, Jessica, additional, Raco, Micheal, additional, Tsang, Micheal, additional, Valettas, Nicholas, additional, Velianou, James, additional, Sheth, Tej, additional, Sibbald, Matthew, additional, Mehta, Shamir R., additional, Pinilla-Echeverri, Natalia, additional, Schwalm, Jon David, additional, Natarajan, Madhu K., additional, Akl, Elie, additional, Tawadros, Sarah, additional, Camargo, Mercedes, additional, Bauer, John, additional, Moxham, Rachel, additional, Dutra, Gustavo, additional, Winter, Jose, additional, and Jolly, Sanjit S., additional

Published
2023
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31. Ticagrelor with or without aspirin in high-risk patients with anaemia undergoing percutaneous coronary intervention: a subgroup analysis of the TWILIGHT trial

Author

Spirito, Alessandro, primary, Kastrati, Adnan, additional, Cao, Davide, additional, Baber, Usman, additional, Sartori, Samantha, additional, Angiolillo, Dominick J, additional, Briguori, Carlo, additional, Cohen, David J, additional, Dangas, George, additional, Dudek, Dariusz, additional, Escaned, Javier, additional, Gibson, C Michael, additional, Zhang, Zhongjie, additional, Huber, Kurt, additional, Kaul, Upendra, additional, Kornowski, Ran, additional, Kunadian, Vijay, additional, Han, Ya-Ling, additional, Mehta, Shamir R, additional, Sardella, Gennaro, additional, Sharma, Samin, additional, Shlofmitz, Richard A, additional, Vogel, Birgit, additional, Collier, Timothy, additional, Pocock, Stuart, additional, and Mehran, Roxana, additional

Published
2023
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33. Effects of routine early treatment with PCSK9 inhibitors in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a randomised, double-blind, sham-controlled trial 

Author

Mehta, Shamir R., primary, Pare, Guillaume, additional, Lonn, Eva M., additional, Jolly, Sanjit S., additional, Natarajan, Madhu K., additional, Pinilla-Echeverri, Natalia, additional, Schwalm, Jon-David, additional, Sheth, Tej N., additional, Sibbald, Matthew, additional, Tsang, Michael, additional, Valettas, Nicholas, additional, Velianou, James L., additional, Lee, Shun Fu, additional, Ferdous, Tahsin, additional, Nauman, Sadia, additional, Nguyen, Helen, additional, McCready, Tara, additional, and McQueen, Matthew J., additional

Published
2022
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34. Design and Rationale of Routine UltrasouNd GuIdance for Vascular AccEss foR Cardiac Procedures: A Randomized TriaL (UNIVERSAL)

Author

Alrashidi, Sulaiman, primary, d’Entremont, Marc-André, additional, Alansari, Omar, additional, Winter, Jose, additional, Brochu, Bradley, additional, Heenan, Laura, additional, Skuriat, Elizabeth, additional, Tyrwhitt, Jessica, additional, Raco, Michael, additional, Tsang, Michael B., additional, Valettas, Nicholas, additional, Velianou, James, additional, Sheth, Tej, additional, Sibbald, Matthew, additional, Mehta, Shamir R., additional, Pinilla-Echeverri, Natalia, additional, Schwalm, Jon David, additional, Natarajan, Madhu K., additional, Kelly, Andrew, additional, Akl, Elie, additional, Tawadros, Sarah, additional, Camargo, Mercedes, additional, Faidi, Walaa, additional, Dutra, Gustavo, additional, and Jolly, Sanjit S., additional

Published
2022
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35. Routine Ultrasonography Guidance for Femoral Vascular Access for Cardiac Procedures

Author

Jolly, Sanjit S., primary, AlRashidi, Sulaiman, additional, d’Entremont, Marc-André, additional, Alansari, Omar, additional, Brochu, Bradley, additional, Heenan, Laura, additional, Skuriat, Elizabeth, additional, Tyrwhitt, Jessica, additional, Raco, Michael, additional, Tsang, Michael, additional, Valettas, Nicholas, additional, Velianou, James L., additional, Sheth, Tej, additional, Sibbald, Matthew, additional, Mehta, Shamir R., additional, Pinilla-Echeverri, Natalia, additional, Schwalm, Jon David, additional, Natarajan, Madhu K., additional, Kelly, Andrew, additional, Akl, Elie, additional, Tawadros, Sarah, additional, Camargo, Mercedes, additional, Faidi, Walaa, additional, Bauer, John, additional, Moxham, Rachel, additional, Nkurunziza, James, additional, Dutra, Gustavo, additional, and Winter, Jose, additional

Published
2022
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36. Cost–effectiveness of ticagrelor in patients with type 2 diabetes and coronary artery disease: a European economic evaluation of the THEMIS trial

Author

Steg, Philippe Gabriel, primary, Bhatt, Deepak L, additional, James, Stefan K, additional, Darlington, Oliver, additional, Hoskin, Louise, additional, Simon, Tabassome, additional, Fox, Kim M, additional, Leiter, Lawrence A, additional, Mehta, Shamir R, additional, Harrington, Robert A, additional, Himmelmann, Anders, additional, Ridderstråle, Wilhelm, additional, Andersson, Marielle, additional, Bueno, Héctor, additional, De Luca, Leonardo, additional, Tank, Amarjeet, additional, Mellström, Carl, additional, and McEwan, Phil, additional

Published
2022
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37. Ticagrelor With or Without Aspirin in Chinese Patients Undergoing Percutaneous Coronary Intervention: A TWILIGHT China Substudy

Author

Han, Yaling, primary, Claessen, Bimmer E., additional, Chen, Shao-Liang, additional, Chunguang, Qiu, additional, Zhou, Yujie, additional, Xu, Yawei, additional, Hailong, Lin, additional, Chen, Jiyan, additional, Qiang, Wu, additional, Zhang, Ruiyan, additional, Luo, Suxin, additional, Li, Yongjun, additional, Zhu, Jianhua, additional, Zhao, Xianxian, additional, Cheng, Xiang, additional, Wang, Jian’an, additional, Su, Xi, additional, Tao, Jianhong, additional, Sun, Yingxian, additional, Wang, Geng, additional, Li, Yi, additional, Bian, Liya, additional, Goel, Ridhima, additional, Sartori, Samantha, additional, Zhang, Zhongjie, additional, Angiolillo, Dominick J., additional, Cohen, David J., additional, Gibson, C. Michael, additional, Kastrati, Adnan, additional, Krucoff, Mitchell, additional, Mehta, Shamir R., additional, Ohman, E. Magnus, additional, Steg, Philippe Gabriel, additional, Liu, Yuqi, additional, Dangas, George, additional, Sharma, Samin, additional, Baber, Usman, additional, and Mehran, Roxana, additional

Published
2022
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38. Effects on Mortality and Major Bleeding of Radial Versus Femoral Artery Access for Coronary Angiography or Percutaneous Coronary Intervention: Meta-Analysis of Individual Patient Data From 7 Multicenter Randomized Clinical Trials

Author

Gargiulo, Giuseppe, Giacoppo, Daniele, Jolly, Sanjit S, Cairns, John, Le May, Michel, Bernat, Ivo, Romagnoli, Enrico, Rao, Sunil V, van Leeuwen, Maarten A H, Mehta, Shamir R, Bertrand, Olivier F, Wells, George A, Meijers, Thomas A, Siontis, George C M, Esposito, Giovanni, Windecker, Stephan, Jüni, Peter, and Valgimigli, Marco

Subjects
610 Medicine & health
Abstract

BACKGROUND In some randomized clinical trials, transradial access (TRA) compared with transfemoral access (TFA) was associated with lower mortality in patients with coronary artery disease undergoing invasive management. We analyzed the effects of TRA versus TFA across multicenter randomized clinical trials and whether these associations are modified by patient or procedural characteristics. METHODS We performed an individual patient data meta-analysis of multicenter randomized clinical trials comparing TRA with TFA among patients undergoing coronary angiography with or without percutaneous coronary intervention. The primary outcome was all-cause mortality and the co-primary outcome was major bleeding at 30 days. The primary analysis was conducted by 1-stage mixed-effects models on the basis of the intention-to-treat cohort. The effect of access site on mortality and major bleeding was assessed further by multivariable analysis. The relationship among access site, bleeding, and mortality was investigated by natural effect model mediation analysis with multivariable adjustment. RESULTS A total of 21 600 patients (10 775 TRA, 10 825 TFA) from 7 randomized clinical trials were included. The median age was 63.9 years, 31.9% were women, 95% presented with acute coronary syndrome, and 75.2% underwent percutaneous coronary intervention. All-cause mortality (1.6% versus 2.1%; hazard ratio, 0.77 [95% CI, 0.63-0.95]; P=0.012) and major bleeding (1.5% versus 2.7%; odds ratio, 0.55 [95% CI, 0.45-0.67]; P

Published
2022
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39. Ticagrelor monotherapy after PCI in high-risk patients with prior MI : A prespecified TWILIGHT Substudy

Author

Chiarito, Mauro, Baber, Usman, Cao, Davide, Sharma, Samin K., Dangas, George, Angiolillo, Dominick J., Briguori, Carlo, Cohen, David J., Dudek, Dariusz, Džavík, Vladimír, Escaned, Javier, Gil, Robert, Hamm, Christian W., Henry, Timothy, Huber, Kurt, Kastrati, Adnan, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell, Kunadian, Vijay, Mehta, Shamir R., Moliterno, David, Ohman, E. Magnus, Oldroyd, Keith, Sardella, Gennaro, Zhongjie, Zhang, Sartori, Samantha, Stefanini, Giulio, Shlofmitz, Richard, Steg, P. Gabriel, Weisz, Giora, Witzenbichler, Bernhard, Han, Ya-Ling, Pocock, Stuart, Gibson, C. Michael, and Mehran, Roxana

Published
2022

40. SYNERGY- EVEROLIMUS ELUTING STENT WITH A BIOABSORBABLE POLYMER IN ST ELEVATION MYOCARDIAL INFARCTION- CLEAR SYNERGY OASIS-9 TRIAL

Author

Jolly, Sanjit S., primary, Mian, Rajibul, additional, Kedev, Sasko, additional, Lavi, Shahar, additional, Moreno, Raul, additional, Montalescot, Gilles, additional, Henry, Timothy D., additional, Asani, Valon, additional, Storey, Robert F., additional, Silvain, Johanne, additional, Spratt, James C.S., additional, Stankovic, Goran, additional, Zafirovska, Biljana, additional, Natarajan, Madhu K., additional, Sabate, Manel, additional, Shreenivas, Satya, additional, Altisent, Omar Abdul-Jawad, additional, Ribas, Núria, additional, and Mehta, Shamir R., additional

Published
2022
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41. Ticagrelor Monotherapy After PCI in High-Risk Patients With Prior MI

Author

Chiarito, Mauro, primary, Baber, Usman, additional, Cao, Davide, additional, Sharma, Samin K., additional, Dangas, George, additional, Angiolillo, Dominick J., additional, Briguori, Carlo, additional, Cohen, David J., additional, Dudek, Dariusz, additional, Džavík, Vladimír, additional, Escaned, Javier, additional, Gil, Robert, additional, Hamm, Christian W., additional, Henry, Timothy, additional, Huber, Kurt, additional, Kastrati, Adnan, additional, Kaul, Upendra, additional, Kornowski, Ran, additional, Krucoff, Mitchell, additional, Kunadian, Vijay, additional, Mehta, Shamir R., additional, Moliterno, David, additional, Ohman, E. Magnus, additional, Oldroyd, Keith, additional, Sardella, Gennaro, additional, Zhongjie, Zhang, additional, Sartori, Samantha, additional, Stefanini, Giulio, additional, Shlofmitz, Richard, additional, Steg, P. Gabriel, additional, Weisz, Giora, additional, Witzenbichler, Bernhard, additional, Han, Ya-ling, additional, Pocock, Stuart, additional, Gibson, C. Michael, additional, and Mehran, Roxana, additional

Published
2022
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42. Prediction of radial crossover in acute coronary syndromes: derivation and validation of the MATRIX score

Author

Gragnano, Felice, primary, Jolly, Sanjit S., additional, Mehta, Shamir R., additional, Branca, Mattia, additional, van Klaveren, David, additional, Frigoli, Enrico, additional, Gargiulo, Giuseppe, additional, Leonardi, Sergio, additional, Vranckx, Pascal, additional, Di Maio, Dario, additional, Monda, Emanuele, additional, Fimiani, Luigi, additional, Fioretti, Vincenzo, additional, Chianese, Salvatore, additional, Andò, Giuseppe, additional, Esposito, Giovanni, additional, Sangiorgi, Giuseppe Massimo, additional, Biondi-Zoccai, Giuseppe, additional, Heg, Dik, additional, Calabrò, Paolo, additional, Windecker, Stephan, additional, Romagnoli, Enrico, additional, and Valgimigli, Marco, additional

Published
2021
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44. Impact of Transcatheter Mitral Valve Repair on Preprocedural and Postprocedural Hospitalization Rates

Author

Czarnecki, Andrew, primary, Han, Lu, additional, Abuzeid, Wael, additional, Cantor, Warren J., additional, Chan, Vincent, additional, Cohen, Eric A., additional, Cohen, Gideon N., additional, Fam, Neil, additional, Garg, Pallav, additional, Hibbert, Benjamin, additional, Mehta, Shamir R., additional, Ong, Geraldine, additional, Osten, Mark, additional, and Ko, Dennis T., additional

Published
2021
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45. Complete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction: Results From the COMPLETE Randomized Clinical Trial.

Author

Mehta, Shamir R., Wang, Jia, Wood, David A., Spertus, John A., Cohen, David J., Mehran, Roxana, Storey, Robert F., Steg, Philippe Gabriel, Pinilla-Echeverri, Natalia, Sheth, Tej, Bainey, Kevin R., Bangalore, Sripal, Cantor, Warren J., Faxon, David P., Feldman, Laurent J., Jolly, Sanjit S., Kunadian, Vijay, Lavi, Shahar, Lopez-Sendon, Jose, and Madan, Mina

Published
2022
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46. Sex Differences Among Patients With High Risk Receiving Ticagrelor With or Without Aspirin After Percutaneous Coronary Intervention

Author

Vogel, Birgit, primary, Baber, Usman, additional, Cohen, David J., additional, Sartori, Samantha, additional, Sharma, Samin K., additional, Angiolillo, Dominick J., additional, Farhan, Serdar, additional, Goel, Ridhima, additional, Zhang, Zhongjie, additional, Briguori, Carlo, additional, Collier, Timothy, additional, Dangas, George, additional, Dudek, Dariusz, additional, Escaned, Javier, additional, Gil, Robert, additional, Han, Ya-ling, additional, Kaul, Upendra, additional, Kornowski, Ran, additional, Krucoff, Mitchell W., additional, Kunadian, Vijay, additional, Mehta, Shamir R., additional, Moliterno, David, additional, Ohman, E. Magnus, additional, Sardella, Gennaro, additional, Witzenbichler, Bernhard, additional, Gibson, C. Michael, additional, Pocock, Stuart, additional, Huber, Kurt, additional, and Mehran, Roxana, additional

Published
2021
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49. Antiplatelet therapy in patients with myocardial infarction without obstructive coronary artery disease.

Author

Bossard, Matthias, Gao, Peggy, Boden, William, Steg, Gabriel, Tanguay, Jean-Francois, Joyner, Cam, Granger, Christopher B., Kastrati, Adnan, Faxon, David, Budaj, Andrzej, Pais, Prem, Di Pasquale, Giuseppe, Valentin, Vicent, Flather, Marcus, Moccetti, Tiziano, Yusuf, Salim, and Mehta, Shamir R.

Subjects
CORONARY artery disease, MYOCARDIAL infarction, PLATELET aggregation inhibitors, MORTALITY, TREATMENT effectiveness, CORONARY arteries
Abstract

Objective: Approximately 10% of patients with myocardial infarction (MI) have no obstructive coronary artery disease. The prognosis and role of intensified antiplatelet therapy in those patients were evaluated.Methods: We analysed data from the Clopidogrel and Aspirin Optimal Dose Usage to Reduce Recurrent Events-Seventh Organisation to Assess Strategies in Ischaemic Symptoms trial randomising patients with ACS referred for early intervention to receive either double-dose (600 mg, day 1; 150 mg, days 2-7; then 75 mg/day) or standard-dose (300 mg, day 1; then 75 mg/day) clopidogrel. Outcomes in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) versus those with obstructive coronary artery disease (CAD) and their relation to standard-dose versus double-dose clopidogrel were evaluated. The primary outcome was cardiovascular (CV) death, MI or stroke at 30 days.Results: We included 23 783 patients with MI and 1599 (6.7%) with MINOCA. Patients with MINOCA were younger, presented more frequently with non-ST-segment elevation MI and had fewer comorbidities. All-cause mortality (0.6% vs 2.3%, p=0.005), CV mortality (0.6% vs 2.2%, p=0.006), repeat MI (0.5% vs 2.3%, p=0.001) and major bleeding (0.6% vs 2.4%, p<0.0001) were lower among patients with MINOCA than among those with obstructive CAD. Among patients with MINOCA, 2.1% of patients in the double-dose clopidogrel group and 0.6% in the standard-dose group experienced a primary outcome (HR 3.57, 95% CI 1.31 to 9.76), whereas in those with obstructive CAD, rates were 4.3% and 4.7%, respectively (HR 0.91, 95% CI 0.80 to 1.03; p value for interaction=0.011).Conclusions: Patients with MINOCA are at lower risk of recurrent CV events compared with patients with MI with obstructive CAD. Compared with a standard clopidogrel-based dual antiplatelet therapy (DAPT) regimen, an intensified dosing strategy appears to offer no additional benefit with a signal of possible harm. Further randomised trials evaluating the effects of potent DAPT in patients with MINOCA are warranted.Trial Registration Number: NCT00335452. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Outcomes in non-ST-segment elevation myocardial infarction patients according to heart failure at admission: Insights from a large trial with systematic early invasive strategy.

Author

Popovic, Batric, Sorbets, Emmanuel, Abtan, Jeremie, Cohen, Marc, Pollack Jr, Charles V., Bode, Christoph, Wiviott, Stephen D., Sabatine, Marc S., Mehta, Shamir R., Ruzyllo, Witold, Rao, Sunil V., French, William J., Kerkar, Prafulla, Kiss, Robert G., Estrada, Jose Luis N., Elbez, Yedid, Ducrocq, Gregory, and Steg, Philippe Gabriel

Published
2021
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