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Your search keyword '"Mario Lorenzo-López"' showing total 4 results
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4 results on '"Mario Lorenzo-López"'

1. Post-operative sepsis-induced acute respiratory distress syndrome: risk factors for a life-threatening complication

Author

Miguel Bardají-Carrillo, Marta Martín-Fernández, Rocío López-Herrero, Juan Manuel Priede-Vimbela, María Heredia-Rodríguez, Esther Gómez-Sánchez, Estefanía Gómez-Pesquera, Mario Lorenzo-López, Pablo Jorge-Monjas, Rodrigo Poves-Álvarez, Jesús Villar, and Eduardo Tamayo

Subjects
ARDS, sepsis, septic shock, surgical patients, post-operative sepsis-induced ARDS, Medicine (General), R5-920
Abstract

IntroductionPrevalence and mortality of the acute respiratory distress syndrome (ARDS) in intensive care units (ICU) are unacceptably high. There is scarce literature on post-operative sepsis-induced ARDS despite that sepsis and major surgery are conditions associated with ARDS. We aimed to examine the impact of post-operative sepsis-induced ARDS on 60-day mortality.MethodsWe performed a secondary analysis of a prospective observational study in 454 patients who underwent major surgery admitted into a single ICU. Patients were stratified in two groups depending on whether they met criteria for ARDS. Primary outcome was 60-day mortality of post-operative sepsis-induced ARDS. Secondary outcome measures were potential risk factors for post-operative sepsis-induced ARDS, and for 60-day mortality.ResultsHigher SOFA score (OR 1.1, 95% CI 1.0–1.3, p = 0.020) and higher lactate (OR 1.9, 95% CI 1.2–2.7, p = 0.004) at study inclusion were independently associated with ARDS. ARDS patients (n = 45) had higher ICU stay [14 (18) vs. 5 (11) days, p < 0.001] and longer need for mechanical ventilation [6 (14) vs. 1 (5) days, p < 0.001] than non-ARDS patients (n = 409). Sixty-day mortality was higher in ARDS patients (OR 2.7, 95% CI 1.1–6.3, p = 0.024). Chronic renal failure (OR 4.0, 95% CI 1.2–13.7, p = 0.026), elevated lactate dehydrogenase (OR 1.7, 95% CI 1.1–2.7, p = 0.015) and higher APACHE II score (OR 2.7, 95% CI 1.3–5.4, p = 0.006) were independently associated with 60-day mortality.ConclusionPost-operative sepsis-induced ARDS is associated with higher 60-day mortality compared to non-ARDS post-operative septic patients. Post-operative septic patients with higher severity of illness have a greater risk of ARDS and worse outcomes. Further investigation is needed in post-operative sepsis-induced ARDS to prevent ARDS.

Published
2024
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2. CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients

Author

Felipe Pérez-García, Maria Ángeles Jiménez-Sousa, Esther Gómez-Sánchez, Hugo Gonzalo-Benito, Amanda Fernández-Rodríguez, Mario Lorenzo-López, María Heredia-Rodríguez, Pedro Martínez-Paz, Estefanía Gómez-Pesquera, Eduardo Tamayo, and Salvador Resino

Subjects
CEACAM7, SNPs, Septic shock, Survival, Major surgery, Microbiology, QR1-502
Abstract

We carried out a retrospective exploratory study on 173 patients who underwent major surgery and developed septic shock after surgery. Our findings suggest that CEACAM7 rs1001578, rs10409040, and rs889365 polymorphisms could influence septic shock-related death in individuals who underwent major surgery.

Published
2022
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3. Relación existente entre Ecocardiografía y Variables Hemodinámicas en una Unidad de Cuidados Intensivos (UCI) Cardiotorácicos

Author

null Carla del Rey de Cabo, null Mario Lorenzo López, null Belén Sánchez Quirós, and null Rocío López Herrero

Subjects
General Materials Science
Abstract

La disfunción del ventrículo izquierdo y la inestabilidad cardiovascular subsiguiente es una de las principales causas de morbimortalidad en los pacientes ingresados en las UCI. La monitorización hemodinámica permite obtener información sobre el estado cardiovascular ayudándonos a obtener un diagnostico adecuado y a guiar la terapia de los pacientes ingresados en dichas unidades. En este estudio los autores pretendían demostrar la existencia de una asociación entre parámetros hemodinámicos y los ecocardiográficos para la evaluación hemodinámica en los pacientes ingresados en UCI.

Published
2022
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4. PCR-based diagnosis of respiratory virus in postsurgical septic patients: A preliminary study before SARS-CoV-2 pandemic

Author

María Heredia-Rodríguez, Sara Balbás-Álvarez, Mario Lorenzo-López, Estefanía Gómez-Pequera, Pablo Jorge-Monjas, Silvia Rojo-Rello, Laura Sánchez-De Prada, Ivan Sanz-Muñoz, José María Eiros, Pedro Martínez-Paz, Hugo Gonzalo-Benito, Álvaro Tamayo-Velasco, Marta Martín-Fernández, Pilar Sánchez-Conde, Eduardo Tamayo, and Esther Gómez-Sánchez

Subjects
Intensive Care Units, COVID-19 Testing, SARS-CoV-2, Sepsis, COVID-19, Humans, General Medicine, Pandemics, Polymerase Chain Reaction
Abstract

Respiratory viruses are part of the normal microbiota of the respiratory tract, which sometimes cause infection with/without respiratory insufficiency and the need for hospital or ICU admission. The aim of this study is to determine the prevalence of respiratory viruses in nontransplanted postoperative septic patients as well as lymphocyte count influence in their presence and its relationship to mortality. 223 nontransplanted postsurgical septic patients were recruited on the Intensive Care Unit (ICU) at Hospital Clínico Universitario de Valladolid prior to the SARS-COV-2 pandemic. Patients were split into 2 groups according to the presence/absence of respiratory viruses. Multivariate logistic regression analysis was used to identify independent factors related to positive respiratory virus PCR test. Respiratory viruses were isolated in 28.7% of patients. 28-day mortality was not significantly different between virus-positive and virus-negative groups. Logistic regression analysis revealed that lymphocyte count ≤ 928/µl is independently associated with a positive PCR result [OR 3.76, 95% CI (1.71-8.26), P = .001] adjusted by platelet count over 128,500/µL [OR 4.27, 95% CI (1.92-9.50) P.001] and the presence of hypertension [OR 2.69, 95% CI (1.13-6.36) P = .025] as confounding variables. Respiratory viruses' detection by using PCR in respiratory samples of nontransplanted postoperative septic patients is frequent. These preliminary results revealed that the presence of lymphopenia on sepsis diagnosis is independently associated to a positive virus result, which is not related to a higher 28-day mortality.

Published
2022
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