Search

A recent study conducted by investigators at the University of Arizona explores the role of ceramide synthases (CerS) in regulating sphingolipids, a class of lipids found in all eukaryotic cells. The researchers analyzed the expression of CerS mRNA and sphingolipid levels in various tissues of mice and found that CerS expression correlated with ceramide species and complex sphingolipids. This suggests that CerS could be potential therapeutic targets for diseases related to disturbances in sphingolipid homeostasis. The study also highlights the relevance of mice as preclinical models for ceramide and sphingolipid research. [Extracted from the article]