1,329 results on '"Manson, JoAnn E"'
Search Results
2. Discovery and validation of plasma, saliva and multi-fluid plasma–saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults
- Author
-
Haslam, Danielle E., Liang, Liming, Guo, Kai, Martínez-Lozano, Marijulie, Pérez, Cynthia M., Lee, Chih-Hao, Morou-Bermudez, Evangelia, Clish, Clary, Wong, David T. W., Manson, JoAnn E., Hu, Frank B., Stampfer, Meir J., Joshipura, Kaumudi, and Bhupathiraju, Shilpa N.
- Published
- 2024
- Full Text
- View/download PDF
3. Associations of tubal ligation and hysterectomy with serum androgen and estrogen metabolites among postmenopausal women in the Women’s Health Initiative Observational Study
- Author
-
Geczik, Ashley M., Michels, Kara A., Anderson, Garnet L., Falk, Roni T., Farland, Leslie V., Manson, JoAnn E., Shadyab, Aladdin H., Pfeiffer, Ruth M., Xu, Xia, and Trabert, Britton
- Published
- 2024
- Full Text
- View/download PDF
4. Ductal carcinoma in situ and cause-specific mortality among younger and older postmenopausal women: the Women’s Health Initiative
- Author
-
Pan, Kathy, Nelson, Rebecca A., Chlebowski, Rowan T., Piela, Rita, Mullooly, Maeve, Simon, Michael S., Rohan, Thomas E., Wactawski-Wende, Jean, Manson, JoAnn E., Mortimer, Joanne E., Lane, Dorothy, and Kruper, Laura
- Published
- 2024
- Full Text
- View/download PDF
5. Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis
- Author
-
Chlebowski, Rowan T., Aragaki, Aaron K., Pan, Kathy, Mortimer, Joanne E., Johnson, Karen C., Wactawski-Wende, Jean, LeBoff, Meryl S., Lavasani, Sayeh, Lane, Dorothy, Nelson, Rebecca A., and Manson, JoAnn E.
- Published
- 2024
- Full Text
- View/download PDF
6. The association of leukocyte telomere length with exceptional longevity among older women
- Author
-
Thai, Nhat Quang N., LaCroix, Andrea Z., Haring, Bernhard, Wactawski-Wende, Jean, Manson, JoAnn E., Posis, Alexander Ivan B., and Shadyab, Aladdin H.
- Published
- 2024
- Full Text
- View/download PDF
7. Associations between Ambient Air Pollutants and Clonal Hematopoiesis of Indeterminate Potential.
- Author
-
Leiser, Claire L, Whitsel, Eric A, Reiner, Alexander, Rich, Stephen S, Rotter, Jerome I, Taylor, Kent D, Tracy, Russel P, Kooperberg, Charles, Smith, Albert Vernon, Manson, JoAnn E, Mychaleckyj, Josyf C, Bick, Alexander G, Szpiro, Adam A, and Kaufman, Joel D
- Subjects
Epidemiology ,Health Sciences ,Aging ,Cancer ,Hematology ,Climate-Related Exposures and Conditions ,Prevention ,Atherosclerosis ,Genetics ,2.2 Factors relating to the physical environment ,Humans ,Female ,Air Pollutants ,Environmental Pollutants ,Nitrogen Dioxide ,Clonal Hematopoiesis ,Cross-Sectional Studies ,Environmental Exposure ,Air Pollution ,Particulate Matter ,Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundClonal hematopoiesis of indeterminate potential (CHIP) is an age-related somatic mutation associated with incident hematologic cancer. Environmental stressors which, like air pollution, generate oxidative stress at the cellular level, may induce somatic mutations and some mutations may provide a selection advantage for persistence and expansion of specific clones.MethodsWe used data from the Multi-Ethnic Study of Atherosclerosis (MESA) N = 4,379 and the Women's Health Initiative (WHI) N = 7,701 to estimate cross-sectional associations between annual average air pollution concentrations at participant address the year before blood draw using validated spatiotemporal models. We used covariate-adjusted logistic regression to estimate risk of CHIP per interquartile range increases in particulate matter (PM2.5; 4 μg/m3) and nitrogen dioxide (NO2; 10 ppb) as ORs (95% confidence intervals).ResultsPrevalence of CHIP at blood draw (variant allele fraction > 2%) was 4.4% and 8.7% in MESA and WHI, respectively. The most common CHIP driver mutation was in DNMT3A. Neither pollutant was associated with CHIP: ORMESA PM2.5 = 1.00 (0.68-1.45), ORMESA NO2 = 1.05 (0.69-1.61), ORWHI PM2.5 = 0.97 (0.86-1.09), ORWHI NO2 = 0.98 (0.88-1.10); or with DNMT3A-driven CHIP.ConclusionsWe did not find evidence that air pollution contributes to CHIP prevalence in two large observational cohorts.ImpactThis is the first study to estimate associations between air pollution and CHIP.
- Published
- 2023
8. The menopausal transition period and cardiovascular risk
- Author
-
Mehta, Jaya M. and Manson, JoAnn E.
- Published
- 2024
- Full Text
- View/download PDF
9. Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials
- Author
-
Kuznia, Sabine, Zhu, Anna, Akutsu, Taisuke, Buring, Julie E, Camargo, Carlos A, Cook, Nancy R, Chen, Li-Ju, Cheng, Ting-Yuan David, Hantunen, Sari, Lee, I-Min, Manson, JoAnn E, Neale, Rachel E, Scragg, Robert, Shadyab, Aladdin H, Sha, Sha, Sluyter, John, Tuomainen, Tomi-Pekka, Urashima, Mitsuyoshi, Virtanen, Jyrki K, Voutilainen, Ari, Wactawski-Wende, Jean, Waterhouse, Mary, Brenner, Hermann, and Schöttker, Ben
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Trials and Supportive Activities ,Complementary and Integrative Health ,Prevention ,Nutrition ,Cancer ,Clinical Research ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Good Health and Well Being ,Humans ,Cholecalciferol ,Dietary Supplements ,Neoplasms ,Prognosis ,Vitamin D ,Mortality ,Survival ,Systematic review ,Individual patient -data ,Individual patient-data ,Biochemistry and Cell Biology ,Neurosciences ,Gerontology ,Biochemistry and cell biology ,Clinical sciences - Abstract
To evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients, a systematic review and meta-analysis of randomised, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted. Overall, 14 RCTs with a total of 104,727 participants (2015 cancer deaths) were identified and 7 RCTs, including 90 % of all study participants (n = 94,068), could be included in the IPD meta-analyses. The main meta-analysis of the 14 RCTs yielded a statistically non-significant reduction in cancer mortality by 6 % (risk ratio (RR) [95%-confidence interval (95%CI)]: 0.94 [0.86-1.02]). Subgroup analyses revealed a 12 % lower cancer mortality in the vitamin D3 group compared with the placebo group in 10 trials with a daily dosing regimen (RR [95%CI]: 0.88 [0.78-0.98]), whereas no mortality reduction was seen in 4 trials using a bolus regimen (RR [95%CI]: 1.07 [0.91-1.24]; p-value for interaction: 0.042). The IPD meta-analysis (RR [95%CI]: 0.93 [0.84; 1.02]) confirmed the finding of all trials. The IPD were used to test effect modification by age, sex, body mass index, ethnicity, baseline serum 25-hydroxyvitamin D concentration, adherence and cancer-related factors but no statistically significant findings were obtained in meta-analyses of all trials. When restricted to trials with daily dosing in a post-hoc analysis, adults aged ≥ 70 years (RR [95%CI]: 0.83 [0.77; 0.98]) and subjects with vitamin D3 therapy initiation before cancer diagnosis (RR [95%CI]: 0.87 [0.69; 0.99]) appeared to benefit most from daily vitamin D3 supplementation. Measurements of baseline 25-hydroxyvitamin D levels and inclusion of other than non-Hispanic White adults were too sparse in the trials to draw conclusions. Results for all-cause and cancer-specific survival of participants with cancer were comparable to those obtained in the general population for cancer mortality. In conclusion, vitamin D3 did not reduce cancer mortality in the main meta-analysis of all RCTs because the observed risk reduction by 6 % was not statistically significant. However, a subgroup analysis revealed that vitamin D3 administered daily, in contrast to bolus supplementation, reduced cancer mortality by 12 %.
- Published
- 2023
10. Investigating Gene-Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits.
- Author
-
Westerman, Kenneth E, Walker, Maura E, Gaynor, Sheila M, Wessel, Jennifer, DiCorpo, Daniel, Ma, Jiantao, Alonso, Alvaro, Aslibekyan, Stella, Baldridge, Abigail S, Bertoni, Alain G, Biggs, Mary L, Brody, Jennifer A, Chen, Yii-Der Ida, Dupuis, Joseé, Goodarzi, Mark O, Guo, Xiuqing, Hasbani, Natalie R, Heath, Adam, Hidalgo, Bertha, Irvin, Marguerite R, Johnson, W Craig, Kalyani, Rita R, Lange, Leslie, Lemaitre, Rozenn N, Liu, Ching-Ti, Liu, Simin, Moon, Jee-Young, Nassir, Rami, Pankow, James S, Pettinger, Mary, Raffield, Laura M, Rasmussen-Torvik, Laura J, Selvin, Elizabeth, Senn, Mackenzie K, Shadyab, Aladdin H, Smith, Albert V, Smith, Nicholas L, Steffen, Lyn, Talegakwar, Sameera, Taylor, Kent D, de Vries, Paul S, Wilson, James G, Wood, Alexis C, Yanek, Lisa R, Yao, Jie, Zheng, Yinan, Boerwinkle, Eric, Morrison, Alanna C, Fornage, Miriam, Russell, Tracy P, Psaty, Bruce M, Levy, Daniel, Heard-Costa, Nancy L, Ramachandran, Vasan S, Mathias, Rasika A, Arnett, Donna K, Kaplan, Robert, North, Kari E, Correa, Adolfo, Carson, April, Rotter, Jerome I, Rich, Stephen S, Manson, JoAnn E, Reiner, Alexander P, Kooperberg, Charles, Florez, Jose C, Meigs, James B, Merino, Jordi, Tobias, Deirdre K, Chen, Han, and Manning, Alisa K
- Subjects
Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Nutrition ,Diabetes ,Human Genome ,Minority Health ,Genetics ,Cardiovascular ,Health Disparities ,Prevention ,Precision Medicine ,Clinical Research ,Metabolic and endocrine ,Good Health and Well Being ,Humans ,Glycated Hemoglobin ,Diet ,Diabetes Mellitus ,Eating ,Guanine Nucleotide Dissociation Inhibitors ,Genome-Wide Association Study ,Medical and Health Sciences ,Endocrinology & Metabolism ,Biomedical and clinical sciences - Abstract
Few studies have demonstrated reproducible gene-diet interactions (GDIs) impacting metabolic disease risk factors, likely due in part to measurement error in dietary intake estimation and insufficient capture of rare genetic variation. We aimed to identify GDIs across the genetic frequency spectrum impacting the macronutrient-glycemia relationship in genetically and culturally diverse cohorts. We analyzed 33,187 participants free of diabetes from 10 National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine program cohorts with whole-genome sequencing, self-reported diet, and glycemic trait data. We fit cohort-specific, multivariable-adjusted linear mixed models for the effect of diet, modeled as an isocaloric substitution of carbohydrate for fat, and its interactions with common and rare variants genome-wide. In main effect meta-analyses, participants consuming more carbohydrate had modestly lower glycemic trait values (e.g., for glycated hemoglobin [HbA1c], -0.013% HbA1c/250 kcal substitution). In GDI meta-analyses, a common African ancestry-enriched variant (rs79762542) reached study-wide significance and replicated in the UK Biobank cohort, indicating a negative carbohydrate-HbA1c association among major allele homozygotes only. Simulations revealed that >150,000 samples may be necessary to identify similar macronutrient GDIs under realistic assumptions about effect size and measurement error. These results generate hypotheses for further exploration of modifiable metabolic disease risk in additional cohorts with African ancestry.Article highlightsWe aimed to identify genetic modifiers of the dietary macronutrient-glycemia relationship using whole-genome sequence data from 10 Trans-Omics for Precision Medicine program cohorts. Substitution models indicated a modest reduction in glycemia associated with an increase in dietary carbohydrate at the expense of fat. Genome-wide interaction analysis identified one African ancestry-enriched variant near the FRAS1 gene that may interact with macronutrient intake to influence hemoglobin A1c. Simulation-based power calculations accounting for measurement error suggested that substantially larger sample sizes may be necessary to discover further gene-macronutrient interactions.
- Published
- 2023
11. Associations of Accelerometer-Measured Physical Activity and Sedentary Time With All-Cause Mortality by Genetic Predisposition for Longevity.
- Author
-
Posis, Alexander Ivan B, Bellettiere, John, Salem, Rany M, LaMonte, Michael J, Manson, JoAnn E, Casanova, Ramon, LaCroix, Andrea Z, and Shadyab, Aladdin H
- Subjects
Public Health ,Health Sciences ,Behavioral and Social Science ,Aging ,Basic Behavioral and Social Science ,Clinical Research ,Prevention ,Cardiovascular ,Metabolic and endocrine ,Good Health and Well Being ,Humans ,Female ,Aged ,Longevity ,Sedentary Behavior ,Genetic Predisposition to Disease ,Accelerometry ,Exercise ,healthy aging ,sedentary behavior ,women?s health ,women’s health ,Human Movement and Sports Sciences ,Gerontology ,Public health ,Sports science and exercise ,Applied and developmental psychology - Abstract
The goal of this study was to examine associations between accelerometer-measured physical activity (PA) and sedentary time (ST) with mortality by a genetic risk score (GRS) for longevity. Among 5,446 women, (mean [SD]: age, 78.2 [6.6] years), 1,022 deaths were observed during 33,350 person-years of follow-up. Using multivariable Cox proportional hazards models, higher light PA and moderate to vigorous PA were associated with lower mortality across all GRS for longevity categories (low/medium/high; all ptrend < .001). Higher ST was associated with higher mortality (ptrend across all GRS categories < .001). Interaction tests for PA and ST with the GRS were not statistically significant. Findings support the importance of higher PA and lower ST for reducing mortality risk in older women, regardless of genetic predisposition for longevity.
- Published
- 2023
12. Correction: Discovery and validation of plasma, saliva and multi-fluid plasma–saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults
- Author
-
Haslam, Danielle E., Liang, Liming, Guo, Kai, Martínez-Lozano, Marijulie, Pérez, Cynthia M., Lee, Chih-Hao, Morou-Bermudez, Evangelia, Clish, Clary, Wong, David T. W., Manson, JoAnn E., Hu, Frank B., Stampfer, Meir J., Joshipura, Kaumudi, and Bhupathiraju, Shilpa N.
- Published
- 2024
- Full Text
- View/download PDF
13. A Review of Hormone and Non-Hormonal Therapy Options for the Treatment of Menopause
- Author
-
Madsen, Tracy E, Sobel, Talia, Negash, Seraphina, Allen, Tara Shrout, Stefanick, Marcia L, Manson, JoAnn E, and Allison, Matthew
- Subjects
Reproductive Medicine ,Biomedical and Clinical Sciences ,Clinical Sciences ,Comparative Effectiveness Research ,Aging ,Clinical Research ,Contraception/Reproduction ,Cardiovascular ,Estrogen ,Reproductive health and childbirth ,Good Health and Well Being ,menopause ,hormone therapy ,cardiovascular disease ,stroke ,Oncology and Carcinogenesis ,Paediatrics and Reproductive Medicine ,Reproductive medicine ,Midwifery - Abstract
Understanding the role of both menopausal hormone therapy (MHT) along with non-hormonal options for the treatment of vasomotor symptoms, sleep disruption, and genitourinary symptoms after menopause is critical to the health of women during middle and later life. Recent updates to the evidence for the treatment of menopausal symptoms pertaining to both hormonal and non-hormonal therapies as well as updated guidance from specialty societies can help guide clinicians in their treatment of women going through natural menopause or with estrogen deficiencies due to primary ovarian insufficiency or induced menopause from surgery or medications. The objective of this narrative review is to provide clinicians with an overview of MHT for the use of menopausal symptoms in women, incorporating updated primary evidence for risk versus benefit profiles, recent specialty society recommendations, and alternative, non-hormonal options. In this review, we summarize literature on the use of MHT for menopause-related symptomatology including options for formulations and dosages of MHT, non-hormonal treatment options, and the risk-benefit profile of MHT including long-term health consequences (eg, cardiovascular disease, cognitive decline, venous thromboembolism, and fracture risk). Finally, we highlight areas in which future research is needed to advance care of women after menopause. In summary, both hormonal (MHT) and non-hormonal options exist to treat symptoms of menopause. There is strong evidence for safety and effectiveness of MHT for the treatment of vasomotor symptoms among women who are less than 60 years of age, less than 10 years since menopause, and without significant cardiometabolic comorbidities. For others, treatment with hormonal versus non-hormonal therapies can be considered based on individual risk profiles, as well as other factors such as drug formulation, therapeutic goals, and symptom severity.
- Published
- 2023
14. Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups
- Author
-
Kurniansyah, Nuzulul, Goodman, Matthew O, Khan, Alyna T, Wang, Jiongming, Feofanova, Elena, Bis, Joshua C, Wiggins, Kerri L, Huffman, Jennifer E, Kelly, Tanika, Elfassy, Tali, Guo, Xiuqing, Palmas, Walter, Lin, Henry J, Hwang, Shih-Jen, Gao, Yan, Young, Kendra, Kinney, Gregory L, Smith, Jennifer A, Yu, Bing, Liu, Simin, Wassertheil-Smoller, Sylvia, Manson, JoAnn E, Zhu, Xiaofeng, Chen, Yii-Der Ida, Lee, I-Te, Gu, C Charles, Lloyd-Jones, Donald M, Zöllner, Sebastian, Fornage, Myriam, Kooperberg, Charles, Correa, Adolfo, Psaty, Bruce M, Arnett, Donna K, Isasi, Carmen R, Rich, Stephen S, Kaplan, Robert C, Redline, Susan, Mitchell, Braxton D, Franceschini, Nora, Levy, Daniel, Rotter, Jerome I, Morrison, Alanna C, and Sofer, Tamar
- Subjects
Human Genome ,Genetics ,Clinical Research ,Cardiovascular ,Good Health and Well Being ,Male ,Female ,Humans ,Blood Pressure ,Population Health ,Risk Factors ,Multifactorial Inheritance ,Ethnicity ,Genome-Wide Association Study ,Genetic Predisposition to Disease - Abstract
We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs developed from multiple independent GWAS, perform best across all race/ethnic backgrounds. Stratified analysis in All of Us shows that PRSs are better predictive of BP in females compared to males, individuals without obesity, and middle-aged (40-60 years) compared to older and younger individuals.
- Published
- 2023
15. The Impact of the COVID-19 Pandemic on Older Women in the Women’s Health Initiative
- Author
-
VoPham, Trang, Harris, Holly R, Tinker, Lesley F, Manson, JoAnn E, Meliker, Jaymie R, Wassertheil-Smoller, Sylvia, Shadyab, Aladdin H, Saquib, Nazmus, Anderson, Garnet L, and Shumaker, Sally A
- Subjects
Health Services and Systems ,Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Infectious Diseases ,Aging ,Prevention ,Behavioral and Social Science ,Lung ,Clinical Research ,Emerging Infectious Diseases ,Management of diseases and conditions ,7.1 Individual care needs ,Generic health relevance ,Good Health and Well Being ,Female ,Humans ,Aged ,Aged ,80 and over ,Pandemics ,COVID-19 ,SARS-CoV-2 ,COVID-19 Testing ,Prospective Studies ,Women's Health ,Cohort study ,Living arrangements ,Well-being ,Gerontology ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundThe coronavirus disease 2019 (COVID-19) pandemic is a health crisis of which older adults are a high-risk group for severe illness and mortality. The objectives of this article are to describe the methods and responses to a COVID-19 survey administered by the Women's Health Initiative (WHI) to assess the impact of the pandemic on older women.MethodsWHI is an ongoing prospective cohort study that recruited 161 808 postmenopausal women from 1993 to 1998. From June 2020 to October 2020, participants in active follow-up were surveyed by mail, phone, or online to assess health and well-being, living situations, lifestyle, health care, and self-reported COVID-19 testing, treatment, and preventive behaviors.ResultsOf 64 061 eligible participants, 49 695 (average age 83.6 years ± 5.6) completed the COVID-19 survey (response rate 77.6%). Many participants reported very good or good well-being (75.6%). Respondents reported being very concerned about the pandemic (51.1%; more common in urban compared to rural areas), with 6.9% reporting disruptions in living arrangements and 9.7% reporting changes in medication access. Participants (54.4%) reported physical activity levels were much less or somewhat less compared to levels before the pandemic, and this was more pronounced in urban areas versus rural areas (55.3% vs 44.4%). Participants engaged in preventive behaviors including wearing a face mask (93.2%). A total of 18.9% reported testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), among whom 3.5% (n = 311) reported testing positive.ConclusionsIn this nationwide survey of older U.S. women, the COVID-19 pandemic was associated with impacts on health and well-being, living situations, lifestyle, health care access, and SARS-CoV-2 testing and preventive behaviors.
- Published
- 2022
16. Cardiometabolic risk factors, physical activity, and postmenopausal breast cancer mortality: results from the Women’s Health Initiative
- Author
-
Dieli-Conwright, Christina M, Nelson, Rebecca A, Simon, Michael S, Irwin, Melinda L, Neuhouser, Marian L, Reding, Kerryn W, Crane, Tracy E, Manson, JoAnn E, Nassir, Rami, Shadyab, Aladdin H, LaMonte, Michael, Qi, Lihing, Thomson, Cynthia A, Kroenke, Candyce H, Pan, Kathy, Chlebowski, Rowan T, and Mortimer, Joanne
- Subjects
Biomedical and Clinical Sciences ,Health Services and Systems ,Health Sciences ,Public Health ,Oncology and Carcinogenesis ,Nutrition ,Aging ,Cardiovascular ,Prevention ,Cancer ,Breast Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Metabolic and endocrine ,Good Health and Well Being ,Breast Neoplasms ,Cardiometabolic Risk Factors ,Exercise ,Female ,Humans ,Metabolic Syndrome ,Postmenopause ,Proportional Hazards Models ,Risk Factors ,Women's Health ,Physical activity ,Metabolic syndrome ,Breast cancer ,Nursing ,Paediatrics and Reproductive Medicine ,Public Health and Health Services ,Obstetrics & Reproductive Medicine ,Reproductive medicine ,Midwifery ,Public health - Abstract
BackgroundHigher physical activity levels are associated with lower breast cancer-specific mortality. In addition, the metabolic syndrome is associated with higher breast cancer-specific mortality. Whether the physical activity association with breast cancer mortality is modified by number of metabolic syndrome components (cardiometabolic risk factors) in postmenopausal women with early-stage breast cancer remains unknown.MethodsCardiovascular risk factors included high waist circumference, hypertension, high cholesterol, and diabetes. Breast cancers were verified by medical record review. Mortality finding were enhanced by serial National Death Index queries. Cox proportional hazards regression models were used to estimate associations between baseline physical activity and subsequent breast cancer-specific and overall mortality following breast cancer diagnosis in Women's Health Initiative participants. These associations were examined after stratifying by cardiometabolic risk factor group.ResultsAmong 161,308 Women's Health Initiative (WHI) participants, 8543 breast cancers occurred after 9.5 years (median) follow-up in women, additionally with information on cardiometabolic risk factors and physical activity at entry. In multi-variable analyses, as measured from cancer diagnosis, higher physical activity levels were associated with lower all-cause mortality risk (hazard ratio [HR] 0.86, 95% confidence interval [CI] 0.78-0.95, trend P
- Published
- 2022
17. Optimism, lifestyle, and longevity in a racially diverse cohort of women
- Author
-
Koga, Hayami K, Trudel‐Fitzgerald, Claudia, Lee, Lewina O, James, Peter, Kroenke, Candyce, Garcia, Lorena, Shadyab, Aladdin H, Salmoirago‐Blotcher, Elena, Manson, JoAnn E, Grodstein, Francine, and Kubzansky, Laura D
- Subjects
Epidemiology ,Public Health ,Health Sciences ,Psychology ,Clinical Research ,Aging ,Nutrition ,Good Health and Well Being ,Ethnicity ,Female ,Health Promotion ,Hispanic or Latino ,Humans ,Life Style ,Longevity ,aging ,longevity ,optimism ,psychological well-being ,race ,ethnicity ,race/ethnicity ,Medical and Health Sciences ,Geriatrics ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundResearch has suggested optimism is associated with healthy aging and exceptional longevity, but most studies were conducted among non-Hispanic White populations. We examined associations of optimism to longevity across racial and ethnic groups and assessed healthy lifestyle as a possible mediating pathway.MethodsParticipants from the Women's Health Initiative (N = 159,255) completed a validated measure of optimism and provided other demographic and health data at baseline. We evaluated associations of optimism with increments in lifespan using accelerated failure time models, and with likelihood of exceptional longevity (survival to age ≥90) using Poisson regression models. Causal mediation analysis explored whether lifestyle-related factors mediated optimism-lifespan associations.ResultsAfter covariate adjustment, the highest versus lowest optimism quartile was associated with 5.4% (95% confidence interval [CI] = 4.5, 6.4%) longer lifespan. Within racial and ethnic subgroups, these estimates were 5.1% (95%CI = 4.0, 6.1%) in non-Hispanic White, 7.6% (95%CI = 3.6, 11.7%) in Black, 5.4% (95%CI = -0.1, 11.2%) in Hispanic/Latina, and 1.5% (95% CI = -5.0, 8.5) in Asian women. A high proportion (53%) of the women achieved exceptional longevity. Participants in the highest versus lowest optimism quartile had greater likelihood of achieving exceptional longevity (e.g., full sample risk ratio = 1.1, 95%CI = 1.1, 1.1). Lifestyle mediated 24% of the optimism-lifespan association in the full sample, 25% in non-Hispanic White, 10% in Black, 24% in Hispanic/Latina, and 43% in Asian women.ConclusionsHigher optimism was associated with longer lifespan and a greater likelihood of achieving exceptional longevity overall and across racial and ethnic groups. The contribution of lifestyle to these associations was modest. Optimism may promote health and longevity in diverse racial and ethnic groups. Future research should investigate these associations in less long-lived populations.
- Published
- 2022
18. Low Diastolic Blood Pressure and Mortality in Older Women. Results From the Women's Health Initiative Long Life Study.
- Author
-
Haring, Bernhard, McGinn, Aileen P, Kamensky, Victor, Allison, Matthew, Stefanick, Marcia L, Schnatz, Peter F, Kuller, Lewis H, Berger, Jeffrey S, Johnson, Karen C, Saquib, Nazmus, Garcia, Lorena, Richey, Phyllis A, Manson, JoAnn E, Alderman, Michael, and Wassertheil-Smoller, Sylvia
- Subjects
Clinical Research ,Aging ,Heart Disease ,Cardiovascular ,Prevention ,Good Health and Well Being ,Aged ,Blood Pressure ,Blood Pressure Determination ,Cardiovascular Diseases ,Female ,Humans ,Hypertension ,Hypotension ,Risk Factors ,Women's Health ,blood pressure ,cardiovascular disease ,diastolic blood pressure ,hypertension ,mortality ,older women ,Clinical Sciences ,Cardiovascular System & Hematology - Abstract
BackgroundRecommended systolic blood pressure targets often do not consider the relationship of low diastolic blood pressure (DBP) levels with cardiovascular disease (CVD) and all-cause mortality risk, which is especially relevant for older people with concurrent comorbidities. We examined the relationship of DBP levels to CVD and all-cause mortality in older women in the Women's Health Initiative Long Life Study (WHI-LLS).MethodsThe study sample included 7,875 women (mean age: 79 years) who underwent a blood pressure measurement at an in-person home visit conducted in 2012-2013. CVD and all-cause mortality were centrally adjudicated. Hazard ratios (HRs) were obtained from adjusted Cox proportional hazards models.ResultsAfter 5 years follow-up, all-cause mortality occurred in 18.4% of women. Compared with a DBP of 80 mm Hg, the fully adjusted HR for mortality was 1.33 (95% confidence interval [CI]: 1.04-1.71) for a DBP of 50 mm Hg and 1.67 (95% CI: 1.29-2.16) for a DBP of 100 mm Hg. The HRs for CVD were 1.14 (95% CI: 0.78-1.67) for a DBP of 50 mm Hg and HR 1.50 (95% CI: 1.03-2.17) for a DBP of 100 mm Hg. The nadir DBP associated with lowest mortality risk was 72 mm Hg overall.ConclusionsIn older women, consideration should be given to the potential adverse effects of low and high DBP. Low DBP may serve as a risk marker. DBP target levels between 68 and 75 mm Hg may avoid higher mortality risk.
- Published
- 2022
19. Birthweight and subsequent risk for thyroid and autoimmune conditions in postmenopausal women
- Author
-
Monahan, Brian, Farland, Leslie V, Shadyab, Aladdin H, Hankinson, Susan E, Manson, JoAnn E, and Spracklen, Cassandra N
- Subjects
Reproductive Medicine ,Biomedical and Clinical Sciences ,Autoimmune Disease ,Prevention ,Arthritis ,Aetiology ,2.4 Surveillance and distribution ,Inflammatory and immune system ,Autoimmune Diseases ,Birth Weight ,Female ,Humans ,Postmenopause ,Proportional Hazards Models ,Risk Factors ,Thyroid Diseases ,Birthweight ,thyroid ,autoimmune disease ,lupus ,rheumatoid arthritis ,hyperthyroid ,hypothyroid ,postmenopausal women ,Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
The objective of this study was to determine the association between birthweight and risk of thyroid and autoimmune conditions in a large sample of postmenopausal women. Baseline data from the Women's Health Initiative (n = 80,806) were used to examine the associations between birthweight category (
- Published
- 2022
20. Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults
- Author
-
LeBoff, Meryl S, Chou, Sharon H, Ratliff, Kristin A, Cook, Nancy R, Khurana, Bharti, Kim, Eunjung, Cawthon, Peggy M, Bauer, Douglas C, Black, Dennis, Gallagher, J Chris, Lee, I-Min, Buring, Julie E, and Manson, JoAnn E
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Aging ,Nutrition ,Clinical Trials and Supportive Activities ,Clinical Research ,Prevention ,Complementary and Integrative Health ,Osteoporosis ,6.1 Pharmaceuticals ,3.3 Nutrition and chemoprevention ,Evaluation of treatments and therapeutic interventions ,Prevention of disease and conditions ,and promotion of well-being ,Musculoskeletal ,Aged ,Cholecalciferol ,Dietary Supplements ,Double-Blind Method ,Fatty Acids ,Omega-3 ,Female ,Fractures ,Bone ,Hip Fractures ,Humans ,Male ,Middle Aged ,Vitamin D Deficiency ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundVitamin D supplements are widely recommended for bone health in the general population, but data on whether they prevent fractures have been inconsistent.MethodsIn an ancillary study of the Vitamin D and Omega-3 Trial (VITAL), we tested whether supplemental vitamin D3 would result in a lower risk of fractures than placebo. VITAL was a two-by-two factorial, randomized, controlled trial that investigated whether supplemental vitamin D3 (2000 IU per day), n-3 fatty acids (1 g per day), or both would prevent cancer and cardiovascular disease in men 50 years of age or older and women 55 years of age or older in the United States. Participants were not recruited on the basis of vitamin D deficiency, low bone mass, or osteoporosis. Incident fractures were reported by participants on annual questionnaires and adjudicated by centralized medical-record review. The primary end points were incident total, nonvertebral, and hip fractures. Proportional-hazards models were used to estimate the treatment effect in intention-to-treat analyses.ResultsAmong 25,871 participants (50.6% women [13,085 of 25,871] and 20.2% Black [5106 of 25,304]), we confirmed 1991 incident fractures in 1551 participants over a median follow-up of 5.3 years. Supplemental vitamin D3, as compared with placebo, did not have a significant effect on total fractures (which occurred in 769 of 12,927 participants in the vitamin D group and in 782 of 12,944 participants in the placebo group; hazard ratio, 0.98; 95% confidence interval [CI], 0.89 to 1.08; P = 0.70), nonvertebral fractures (hazard ratio, 0.97; 95% CI, 0.87 to 1.07; P = 0.50), or hip fractures (hazard ratio, 1.01; 95% CI, 0.70 to 1.47; P = 0.96). There was no modification of the treatment effect according to baseline characteristics, including age, sex, race or ethnic group, body-mass index, or serum 25-hydroxyvitamin D levels. There were no substantial between-group differences in adverse events as assessed in the parent trial.ConclusionsVitamin D3 supplementation did not result in a significantly lower risk of fractures than placebo among generally healthy midlife and older adults who were not selected for vitamin D deficiency, low bone mass, or osteoporosis. (Funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases; VITAL ClinicalTrials.gov number, NCT01704859.).
- Published
- 2022
21. Physical function trends and their association with mortality in postmenopausal women.
- Author
-
Laddu, Deepika R, Saquib, Nazmus, Manson, JoAnn E, Arena, Ross, Shadyab, Aladdin H, Weitlauf, Julie C, Hovey, Kathleen M, Andrews, Christopher, Banack, Hailey, Stefanick, Marcia L, LaMonte, Michael J, and Women’s Health Initiative Investigators
- Subjects
Women’s Health Initiative Investigators ,Humans ,Neoplasms ,Cardiovascular Diseases ,Proportional Hazards Models ,Risk Factors ,Cohort Studies ,Postmenopause ,Aged ,Female ,Aging ,Clinical Research ,Behavioral and Social Science ,Cancer ,Basic Behavioral and Social Science ,Prevention ,Good Health and Well Being ,All-cause mortality ,CVD mortality ,Gait speed ,Geriatric assessment ,Physical functioning ,RAND-36 ,Medical and Health Sciences ,Obstetrics & Reproductive Medicine - Abstract
ObjectiveResearch is limited regarding the predictive utility of the RAND-36 questionnaire and physical performance tests in relation to all-cause, cardiovascular disease (CVD), and total-cancer mortality in older women.MethodsData on the RAND-36 questionnaire, gait speed, and chair stand performance were assessed in 5,534 women aged ≥65 years at baseline. A subset (n = 298) had physical function assessments additionally at follow-up (years 1, 3, or 6). Multivariable Cox proportional hazards regression models estimated associations (HR) for a 1-standard deviation (SD) difference in baseline RAND-36 scores and performance tests (alone and combined) with mortality outcomes in the overall cohort and in models stratified by enrollment age (
- Published
- 2022
22. Discovering the direct relations between nutrients and epigenetic ageing
- Author
-
Grootswagers, Pol, Bach, Daimy, Biemans, Ynte, Behrouzi, Pariya, Horvath, Steve, Kramer, Charlotte S., Liu, Simin, Manson, JoAnn E., Shadyab, Aladdin H., Stewart, James D., Whitsel, Eric, Yang, Bo, and de Groot, Lisette
- Published
- 2024
- Full Text
- View/download PDF
23. Ultra-processed foods and cardiovascular disease: analysis of three large US prospective cohorts and a systematic review and meta-analysis of prospective cohort studies
- Author
-
Mendoza, Kenny, Smith-Warner, Stephanie A., Rossato, Sinara Laurini, Khandpur, Neha, Manson, JoAnn E., Qi, Lu, Rimm, Eric B., Mukamal, Kenneth J., Willett, Walter C., Wang, Molin, Hu, Frank B., Mattei, Josiemer, and Sun, Qi
- Published
- 2024
- Full Text
- View/download PDF
24. Heart Failure Risk Among African-American Women With an ICAM1 Missense Variant
- Author
-
Dalal, Prarthana J., Giro, Pedro, Rasmussen-Torvik, Laura J., Yancy, Clyde W., Shah, Sanjiv J., Reiner, Alex P., Haring, Bernhard, Martin, Lisa Warsinger, Wells, Gretchen L., Manson, JoAnn E., Kooperberg, Charles, Eaton, Charles B., and Patel, Ravi B.
- Published
- 2024
- Full Text
- View/download PDF
25. Vitamin D and heart failure risk among individuals with type 2 diabetes: observational and Mendelian randomization studies
- Author
-
Chen, Xue, Xu, Jiajing, Wan, Zhenzhen, Geng, Tingting, Zhu, Kai, Li, Rui, Lu, Qi, Lin, Xiaoyu, Liu, Sen, Ou, Yunjing, Yang, Kun, An, Pan, Manson, JoAnn E, and Liu, Gang
- Published
- 2024
- Full Text
- View/download PDF
26. Associations of steps per day and step intensity with the risk of cancer: Findings from the Women's Health Accelerometry Collaboration cohort
- Author
-
Cuthbertson, Carmen C., Evenson, Kelly R., Wen, Fang, Moore, Christopher C., Howard, Annie G., Di, Chongzhi, Parada, Humberto, Jr, Matthews, Charles E., Manson, JoAnn E., Buring, Julie, Shiroma, Eric J., LaCroix, Andrea Z., and Lee, I-Min
- Published
- 2024
- Full Text
- View/download PDF
27. Associations of social determinants of health with life expectancy and future health risks among individuals with type 2 diabetes: two nationwide cohort studies in the UK and USA
- Author
-
Zhong, Jiale, Zhang, Yanbo, Zhu, Kai, Li, Rui, Zhou, Xiaotao, Yao, Pang, Franco, Oscar H, Manson, JoAnn E, Pan, An, and Liu, Gang
- Published
- 2024
- Full Text
- View/download PDF
28. Multidisciplinary approach combining food metabolomics and epidemiology identifies meglutol as an important bioactive metabolite in tempe, an Indonesian fermented food
- Author
-
Iman, Marvin N., Haslam, Danielle E., Liang, Liming, Guo, Kai, Joshipura, Kaumudi, Pérez, Cynthia M., Clish, Clary, Tucker, Katherine L., Manson, JoAnn E., Bhupathiraju, Shilpa N., Fukusaki, Eiichiro, Lasky-Su, Jessica, and Putri, Sastia P.
- Published
- 2024
- Full Text
- View/download PDF
29. 24-h urinary sodium and potassium excretions, plasma metabolomic profiles, and cardiometabolic biomarkers in the United States adults: a cross-sectional study
- Author
-
Hamaya, Rikuta, Sun, Qi, Li, Jun, Yun, Huan, Wang, Fenglei, Curhan, Gary C, Huang, Tianyi, Manson, JoAnn E, Willett, Walter C, Rimm, Eric B, Clish, Clary, Liang, Liming, Hu, Frank B, and Ma, Yuan
- Published
- 2024
- Full Text
- View/download PDF
30. Joint effects of one year of marine omega-3 fatty acid supplementation and participant dietary fish intake upon circulating lipid mediators of inflammation resolution in a randomized controlled trial
- Author
-
Oakes, Emily G., Vlasakov, Iliyan, Kotler, Gregory, Bubes, Vadim, Mora, Samia, Tatituri, Raju, Cook, Nancy R., Manson, JoAnn E., and Costenbader, Karen H.
- Published
- 2024
- Full Text
- View/download PDF
31. Systolic Blood Pressure and Survival to Very Old Age: Results From the Women’s Health Initiative
- Author
-
Haring, Bernhard, Andrews, Chris A., Hovey, Kathleen, Shadyab, Aladdin H., LaCroix, Andrea, Martin, Lisa Warsinger, Rosal, Milagros C., Kuller, Lewis H., Salmoirago-Blotcher, Elena, Saquib, Nazmus, Koo, Patrick, Laddu, Deepika, Stefanick, Marcia L., Manson, JoAnn E., Wassertheil-Smoller, Sylvia, and LaMonte, Michael J.
- Published
- 2024
- Full Text
- View/download PDF
32. Effects of Vitamin D3 Supplementation on Incident Fractures by eGFR in VITAL
- Author
-
Hsu, Simon, Zelnick, Leila R., Buring, Julie E., Chou, Sharon H., Cook, Nancy R., DʼAgostino, Denise, Hoofnagle, Andrew N., LeBoff, Meryl S., Lee, I-Min, Limonte, Christine P., Sesso, Howard D., Manson, JoAnn E., and de Boer, Ian H.
- Published
- 2024
- Full Text
- View/download PDF
33. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies
- Author
-
Qi, Qibin, Li, Jun, Yu, Bing, Moon, Jee-Young, Chai, Jin C, Merino, Jordi, Hu, Jie, Ruiz-Canela, Miguel, Rebholz, Casey, Wang, Zheng, Usyk, Mykhaylo, Chen, Guo-Chong, Porneala, Bianca C, Wang, Wenshuang, Nguyen, Ngoc Quynh, Feofanova, Elena V, Grove, Megan L, Wang, Thomas J, Gerszten, Robert E, Dupuis, Josée, Salas-Salvadó, Jordi, Bao, Wei, Perkins, David L, Daviglus, Martha L, Thyagarajan, Bharat, Cai, Jianwen, Wang, Tao, Manson, JoAnn E, Martínez-González, Miguel A, Selvin, Elizabeth, Rexrode, Kathryn M, Clish, Clary B, Hu, Frank B, Meigs, James B, Knight, Rob, Burk, Robert D, Boerwinkle, Eric, and Kaplan, Robert C
- Subjects
Obesity ,Human Genome ,Prevention ,Genetics ,Nutrition ,Diabetes ,2.2 Factors relating to the physical environment ,Aetiology ,Metabolic and endocrine ,Oral and gastrointestinal ,Bacteria ,Cohort Studies ,Diabetes Mellitus ,Type 2 ,Diet ,Gastrointestinal Microbiome ,Humans ,Kynurenine ,Lactase ,Tryptophan ,diabetes mellitus ,dietary factors ,genetics ,Clinical Sciences ,Paediatrics and Reproductive Medicine ,Gastroenterology & Hepatology - Abstract
ObjectiveTryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet and gut microbiota.MethodWe analysed associations between circulating levels of 11 tryptophan metabolites and incident T2D in 9180 participants of diverse racial/ethnic backgrounds from five cohorts. We examined host genome-wide variants, dietary intake and gut microbiome associated with these metabolites.ResultsTryptophan, four kynurenine-pathway metabolites (kynurenine, kynurenate, xanthurenate and quinolinate) and indolelactate were positively associated with T2D risk, while indolepropionate was inversely associated with T2D risk. We identified multiple host genetic variants, dietary factors, gut bacteria and their potential interplay associated with these T2D-relaetd metabolites. Intakes of fibre-rich foods, but not protein/tryptophan-rich foods, were the dietary factors most strongly associated with tryptophan metabolites. The fibre-indolepropionate association was partially explained by indolepropionate-associated gut bacteria, mostly fibre-using Firmicutes. We identified a novel association between a host functional LCT variant (determining lactase persistence) and serum indolepropionate, which might be related to a host gene-diet interaction on gut Bifidobacterium, a probiotic bacterium significantly associated with indolepropionate independent of other fibre-related bacteria. Higher milk intake was associated with higher levels of gut Bifidobacterium and serum indolepropionate only among genetically lactase non-persistent individuals.ConclusionHigher milk intake among lactase non-persistent individuals, and higher fibre intake were associated with a favourable profile of circulating tryptophan metabolites for T2D, potentially through the host-microbial cross-talk shifting tryptophan metabolism toward gut microbial indolepropionate production.
- Published
- 2022
34. Association of Epigenetic Age Acceleration with Incident Mild Cognitive Impairment and Dementia Among Older Women
- Author
-
Shadyab, Aladdin H, McEvoy, Linda K, Horvath, Steve, Whitsel, Eric A, Rapp, Stephen R, Espeland, Mark A, Resnick, Susan M, Manson, JoAnn E, Chen, Jiu-Chiuan, Chen, Brian H, Li, Wenjun, Hayden, Kathleen M, Bao, Wei, Kusters, Cynthia DJ, and LaCroix, Andrea Z
- Subjects
Alzheimer's Disease ,Heart Disease ,Dementia ,Prevention ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Cardiovascular ,Aging ,Clinical Research ,Neurodegenerative ,Brain Disorders ,Acquired Cognitive Impairment ,Neurological ,Acceleration ,Aged ,Cognitive Dysfunction ,Cohort Studies ,Epigenesis ,Genetic ,Female ,Humans ,Prospective Studies ,Alzheimer's disease ,Biomarker ,Cognitive aging ,Alzheimer’s disease ,Clinical Sciences ,Gerontology - Abstract
BackgroundEpigenetic age acceleration (AgeAccel), which indicates faster biological aging relative to chronological age, has been associated with lower cognitive function. However, the association of AgeAccel with mild cognitive impairment (MCI) or dementia is not well-understood. We examined associations of 4 AgeAccel measures with incident MCI and dementia.MethodsThis prospective analysis included 578 older women from the Women's Health Initiative Memory Study selected for a case-cohort study of coronary heart disease (CHD). Women were free of CHD and cognitive impairment at baseline. Associations of AgeAccel measures (intrinsic AgeAccel [IEAA], extrinsic AgeAccel [EEAA], AgeAccelPheno, and AgeAccelGrim) with risks for incident adjudicated diagnoses of MCI and dementia overall and stratified by incident CHD status were evaluated.ResultsIEAA was not significantly associated with MCI (HR, 1.23; 95% CI, 0.99-1.53), dementia (HR, 1.10; 95% CI, 0.88-1.38), or cognitive impairment (HR, 1.18; 95% CI, 0.99-1.40). In stratified analysis by incident CHD status, there was a 39% (HR, 1.39; 95% CI, 1.07-1.81) significantly higher risk of MCI for every 5-year increase in IEAA among women who developed CHD during follow-up. Other AgeAccel measures were not significantly associated with MCI or dementia.ConclusionsIEAA was not significantly associated with cognitive impairment overall but was associated with impairment among women who developed CHD. Larger studies designed to examine associations of AgeAccel with cognitive impairment are needed, including exploration of whether associations are stronger in the setting of underlying vascular pathologies.
- Published
- 2022
35. Ambient air pollution exposure and increasing depressive symptoms in older women: The mediating role of the prefrontal cortex and insula
- Author
-
Petkus, Andrew J, Resnick, Susan M, Wang, Xinhui, Beavers, Daniel P, Espeland, Mark A, Gatz, Margaret, Gruenewald, Tara, Millstein, Joshua, Chui, Helena C, Kaufman, Joel D, Manson, JoAnn E, Wellenius, Gregory A, Whitsel, Eric A, Widaman, Keith, Younan, Diana, and Chen, Jiu-Chiuan
- Subjects
Pollution and Contamination ,Biological Psychology ,Epidemiology ,Environmental Sciences ,Health Sciences ,Psychology ,Clinical Research ,Mental Health ,Biomedical Imaging ,Brain Disorders ,Neurosciences ,Climate-Related Exposures and Conditions ,Depression ,Behavioral and Social Science ,Aging ,2.2 Factors relating to the physical environment ,Aetiology ,Mental health ,Neurological ,Aged ,Aged ,80 and over ,Air Pollutants ,Air Pollution ,Cross-Sectional Studies ,Environmental Exposure ,Female ,Humans ,Nitrogen Dioxide ,Particulate Matter ,Prefrontal Cortex ,Prospective Studies ,Air pollution ,Brain aging ,Structural magnetic resonance imaging - Abstract
Exposures to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) have been associated with the emergence of depressive symptoms in older adulthood, although most studies used cross-sectional outcome measures. Elucidating the brain structures mediating the adverse effects can strengthen the causal role between air pollution and increasing depressive symptoms. We evaluated whether smaller volumes of brain structures implicated in late-life depression mediate associations between ambient air pollution exposure and changes in depressive symptoms. This prospective study included 764 community-dwelling older women (aged 81.6 ± 3.6 in 2008-2010) from the Women's Health Initiative Memory Study (WHIMS) Magnetic Resonance Imaging study (WHIMS-MRI; 2005-06) and WHIMS-Epidemiology of Cognitive Health Outcomes (WHIMS-ECHO; 2008-16). Three-year average annual mean concentrations (scaled by interquartile range [IQR]) of ambient PM2.5 (in μg/m3; IQR = 3.14 μg/m3) and NO2 (in ppb; IQR = 7.80 ppb) before WHIMS-MRI were estimated at participants' addresses via spatiotemporal models. Mediators included structural brain MRI-derived grey matter volumes of the prefrontal cortex and structures of the limbic-cortical-striatal-pallidal-thalamic circuit. Depressive symptoms were assessed annually by the 15-item Geriatric Depression Scale. Structural equation models were constructed to estimate associations between exposure, structural brain volumes, and depressive symptoms. Increased exposures (by each IQR) were associated with greater annual increases in depressive symptoms (βPM2.5 = 0.022; 95% Confidence Interval (CI) = 0.003, 0.042; βNO2 = 0.019; 95% CI = 0.001, 0.037). The smaller volume of prefrontal cortex associated with exposures partially mediated the associations of increased depressive symptoms with NO2 (8%) and PM2.5 (13%), and smaller insula volume associated with NO2 contributed modestly (13%) to the subsequent increase in depressive symptoms. We demonstrate the first evidence that the smaller volumes of the prefrontal cortex and insula may mediate the subsequent increases in depressive symptoms associated with late-life exposures to NO2 and PM2.5.
- Published
- 2022
36. Racial/Ethnic Disparities in Alzheimer’s Disease Risk: Role of Exposure to Ambient Fine Particles
- Author
-
Younan, Diana, Wang, Xinhui, Gruenewald, Tara, Gatz, Margaret, Serre, Marc L, Vizuete, William, Braskie, Meredith N, Woods, Nancy F, Kahe, Ka, Garcia, Lorena, Lurmann, Fred, Manson, JoAnn E, Chui, Helena C, Wallace, Robert B, Espeland, Mark A, and Chen, Jiu-Chiuan
- Subjects
Dementia ,Behavioral and Social Science ,Alzheimer's Disease ,Aging ,Mental Health ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurosciences ,Acquired Cognitive Impairment ,Brain Disorders ,Neurodegenerative ,Cardiovascular ,Prevention ,Clinical Research ,Good Health and Well Being ,Aged ,Air Pollutants ,Air Pollution ,Alzheimer Disease ,Environmental Exposure ,Female ,Humans ,Particulate Matter ,Prospective Studies ,Air pollution ,Epidemiology ,Incidence ,Clinical Sciences ,Gerontology - Abstract
BackgroundWhether racial/ethnic disparities in Alzheimer's disease (AD) risk may be explained by ambient fine particles (PM2.5) has not been studied.MethodWe conducted a prospective, population-based study on a cohort of Black (n = 481) and White (n = 6 004) older women (aged 65-79) without dementia at enrollment (1995-1998). Cox models accounting for competing risk were used to estimate the hazard ratio (HR) for racial/ethnic disparities in AD (1996-2010) defined by Diagnostic and Statistical Manual of Mental Disorders, 4th edition and the association with time-varying annual average PM2.5 (1999-2010) estimated by spatiotemporal model.ResultsOver an average follow-up of 8.3 (±3.5) years with 158 incident cases (21 in Black women), the racial disparities in AD risk (range of adjusted HRBlack women = 1.85-2.41) observed in various models could not be explained by geographic region, age, socioeconomic characteristics, lifestyle factors, cardiovascular risk factors, and hormone therapy assignment. Estimated PM2.5 exposure was higher in Black (14.38 ± 2.21 µg/m3) than in White (12.55 ± 2.76 µg/m3) women, and further adjustment for the association between PM2.5 and AD (adjusted HRPM2.5 = 1.18-1.28) slightly reduced the racial disparities by 2%-6% (HRBlack women = 1.81-2.26). The observed association between PM2.5 and AD risk was ~2 times greater in Black (HRPM2.5 = 2.10-2.60) than in White (HRPM2.5 = 1.07-1.15) women (range of interaction ps:
- Published
- 2022
37. Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE).
- Author
-
Lai, Heidi TM, Imamura, Fumiaki, Korat, Andres V Ardisson, Murphy, Rachel A, Tintle, Nathan, Bassett, Julie K, Chen, Jiaying, Kröger, Janine, Chien, Kuo-Liong, Senn, Mackenzie, Wood, Alexis C, Forouhi, Nita G, Schulze, Matthias B, Harris, William S, Vasan, Ramachandran S, Hu, Frank, Giles, Graham G, Hodge, Allison, Djousse, Luc, Brouwer, Ingeborg A, Qian, Frank, Sun, Qi, Wu, Jason HY, Marklund, Matti, Lemaitre, Rozenn N, Siscovick, David S, Fretts, Amanda M, Shadyab, Aladdin H, Manson, JoAnn E, Howard, Barbara V, Robinson, Jennifer G, Wallace, Robert B, Wareham, Nick J, Chen, Yii-Der Ida, Rotter, Jerome I, Tsai, Michael Y, Micha, Renata, and Mozaffarian, Dariush
- Subjects
Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Diabetes ,Clinical Research ,Metabolic and endocrine ,Adolescent ,Adult ,Biomarkers ,Cohort Studies ,Diabetes Mellitus ,Type 2 ,Fatty Acids ,Humans ,Outcome Assessment ,Health Care ,Prospective Studies ,Risk Factors ,Trans Fatty Acids ,Fatty Acids and Outcomes Research Consortium ,Medical and Health Sciences ,Endocrinology & Metabolism ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveTrans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis.Research design and methodsWe included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged ≥18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics.ResultsDuring a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-18:2, 0.89 (0.73-1.07); and trans/cis-18:2, 0.87 (0.73-1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67-0.99], 0.86 [0.75-0.99], and 0.84 [0.74-0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P ≥ 0.1).ConclusionsCirculating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.
- Published
- 2022
38. Association between race/ethnicity and income on the likelihood of coronary revascularization among postmenopausal women with acute myocardial infarction: Women's health initiative study
- Author
-
Tertulien, Tarryn, Roberts, Mary B, Eaton, Charles B, Cene, Crystal W, Corbie-Smith, Giselle, Manson, JoAnn E, Allison, Matthew, Nassir, Rami, and Breathett, Khadijah
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Cardiovascular ,Atherosclerosis ,Heart Disease ,Ethnicity ,Female ,Humans ,Myocardial Infarction ,Myocardial Revascularization ,Postmenopause ,White People ,Women's Health ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundHistorically, race, income, and gender were associated with likelihood of receipt of coronary revascularization for acute myocardial infarction (AMI). Given public health initiatives such as Healthy People 2010, it is unclear whether race and income remain associated with the likelihood of coronary revascularization among women with AMI.MethodsUsing the Women's Health Initiative Study, hazards ratio (HR) of revascularization for AMI was compared for Black and Hispanic women vs White women and among women with annual income
- Published
- 2022
39. Use of melatonin supplements and risk of type 2 diabetes and cardiovascular diseases in the USA: insights from three prospective cohort studies
- Author
-
Li, Yanping, Huang, Tianyi, Redline, Susan, Willett, Walter C, Manson, JoAnn E, Schernhammer, Eva S, and Hu, Frank B
- Published
- 2024
- Full Text
- View/download PDF
40. Biomarker-assessed total energy intake and its cohort study association with all-cause mortality in postmenopausal females
- Author
-
Prentice, Ross L, Aragaki, Aaron K, Zheng, Cheng, Manson, JoAnn E, Tinker, Lesley F, Ravelli, Michele N, Mossavar-Rahmani, Yasmin, Wallace, Robert B, Tooze, Janet A, Johnson, Karen C, Lampe, Johanna W, Neuhouser, Marian L, and Schoeller, Dale A
- Published
- 2024
- Full Text
- View/download PDF
41. A randomized clinical trial of omega-3 fatty acid and vitamin D supplementation on electrocardiographic risk profiles
- Author
-
Tikkanen, Jani T., Soliman, Elsayed Z., Pester, Julie, Danik, Jacqueline S., Gomelskya, Natalia, Copeland, Trisha, Lee, I.-Min, Buring, Julie E., Manson, JoAnn E., Cook, Nancy R., and Albert, Christine M.
- Published
- 2023
- Full Text
- View/download PDF
42. Histamine H2 Receptor Antagonists and Heart Failure Risk in Postmenopausal Women: The Women’s Health Initiative
- Author
-
Larson, Sophia R, Vasbinder, Alexi L, Reding, Kerryn W, Leary, Peter J, Branch, Kelley R, Shadyab, Aladdin H, Johnson, Karen C, Haring, Bernhard, Wallace, Robert, Manson, JoAnn E, Anderson, Garnet, and Cheng, Richard K
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Heart Disease ,Cardiovascular ,Prevention ,Aging ,Female ,Heart Failure ,Histamine ,Histamine H2 Antagonists ,Humans ,Incidence ,Postmenopause ,Risk Factors ,Women's Health ,heart failure ,postmenopausal women ,prevention ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
Background Prior studies suggested lower risk of heart failure (HF) in individuals taking H2 receptor antagonists (H2RA) compared with H2RA nonusers in relatively small studies. We evaluated the association of H2RA use and incident HF in postmenopausal women in the large-scale WHI (Women's Health Initiative) study. Methods and Results This study included postmenopausal women from the WHI without a history of HF at baseline. HF was defined as first incident hospitalization for HF and physician adjudicated. Multivariable Cox proportional hazards regression models evaluated the association of H2RA use as a time-varying exposure with HF risk, after adjustment for demographic, lifestyle, and medical history variables. Sensitivity analyses examined (1) risk of HF stratified by the ARIC (Atherosclerosis Risk in Communities) score, (2) propensity score matching on H2RA use, (3) use of proton pump inhibitors rather than H2RA nonuse as the referent, and (4) exclusion of those taking diuretics at baseline. The primary analysis included 158 854 women after exclusion criteria, of whom 9757 (6.1%) were H2RA users. During median 8.2 years of follow-up, 376 H2RA users (4.9 events/1000 person-years) and 3206 nonusers (2.7 events/1000 person-years) developed incident HF. After multivariable adjustment, there was no association between H2RA use and HF in the primary analysis (hazard ratio, 1.07; 95% CI, 0.94-1.22; P=0.31) or in any of the sensitivity analyses. Conclusions Clinical H2RA use was not associated with incident HF among postmenopausal women. Future studies are needed to evaluate potential effect modification by sex, HF severity, or patterns of use on H2RA exposure and HF risk. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT00000611.
- Published
- 2022
43. Clonal Hematopoiesis Is Associated With Higher Risk of Stroke
- Author
-
Bhattacharya, Romit, Zekavat, Seyedeh M, Haessler, Jeffrey, Fornage, Myriam, Raffield, Laura, Uddin, Mesbah, Bick, Alexander G, Niroula, Abhishek, Yu, Bing, Gibson, Christopher, Griffin, Gabriel, Morrison, Alanna C, Psaty, Bruce M, Longstreth, William T, Bis, Joshua C, Rich, Stephen S, Rotter, Jerome I, Tracy, Russell P, Correa, Adolfo, Seshadri, Sudha, Johnson, Andrew, Collins, Jason M, Hayden, Kathleen M, Madsen, Tracy E, Ballantyne, Christie M, Jaiswal, Siddhartha, Ebert, Benjamin L, Kooperberg, Charles, Manson, JoAnn E, Whitsel, Eric A, Program, NHLBI Trans-Omics for Precision Medicine, Natarajan, Pradeep, and Reiner, Alexander P
- Subjects
Epidemiology ,Health Sciences ,Human Genome ,Prevention ,Brain Disorders ,Neurosciences ,Stroke ,Genetics ,Aging ,Good Health and Well Being ,Adult ,Aged ,Aged ,80 and over ,Clonal Hematopoiesis ,DNA Methyltransferase 3A ,DNA-Binding Proteins ,Dioxygenases ,Female ,Hemorrhagic Stroke ,Humans ,Incidence ,Ischemic Stroke ,Male ,Middle Aged ,Prevalence ,Repressor Proteins ,Risk ,NHLBI Trans-Omics for Precision Medicine Program ,brain ischemia ,cardiovascular diseases ,clonal hematopoiesis ,humans ,prospective studies ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Neurology & Neurosurgery ,Clinical sciences ,Allied health and rehabilitation science - Abstract
Background and purposeClonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was reported previously in an exploratory analysis including a small number of incident stroke cases without replication and lack of stroke subphenotyping. The purpose of this study was to discover whether CHIP is a risk factor for ischemic or hemorrhagic stroke.MethodsWe utilized plasma genome sequence data of blood DNA to identify CHIP in 78 752 individuals from 8 prospective cohorts and biobanks. We then assessed the association of CHIP and commonly mutated individual CHIP driver genes (DNMT3A, TET2, and ASXL1) with any stroke, ischemic stroke, and hemorrhagic stroke.ResultsCHIP was associated with an increased risk of total stroke (hazard ratio, 1.14 [95% CI, 1.03-1.27]; P=0.01) after adjustment for age, sex, and race. We observed associations with CHIP with risk of hemorrhagic stroke (hazard ratio, 1.24 [95% CI, 1.01-1.51]; P=0.04) and with small vessel ischemic stroke subtypes. In gene-specific association results, TET2 showed the strongest association with total stroke and ischemic stroke, whereas DMNT3A and TET2 were each associated with increased risk of hemorrhagic stroke.ConclusionsCHIP is associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke. Future studies clarifying the relationship between CHIP and subtypes of stroke are needed.
- Published
- 2022
44. Social Isolation and Incident Heart Failure Hospitalization in Older Women: Women’s Health Initiative Study Findings
- Author
-
Cené, Crystal W, Leng, Xiaoyan Iris, Faraz, Khushnood, Allison, Matthew, Breathett, Khadijah, Bird, Chloe, Coday, Mace, Corbie‐Smith, Giselle, Foraker, Randi, Ijioma, Nkechinyere N, Rosal, Milagros C, Sealy‐Jefferson, Shawnita, Shippee, Tetyana P, Kroenke, Candyce H, Rossouw, Jacques, Ludlam, Shari, McGowan, Joan, Ford, Leslie, Geller, Nancy, Anderson, Garnet, Prentice, Ross, LaCroix, Andrea, Kooperberg, Charles, Manson, JoAnn E, Howard, Barbara V, Stefanick, Marcia L, Jackson, Rebecca, Thomson, Cynthia A, Wactawski‐Wende, Jean, Limacher, Marian, Robinson, Jennifer, Kuller, Lewis, Shumaker, Sally, and Brunner, Robert
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Cardiovascular ,Heart Disease ,Behavioral and Social Science ,Prevention ,Depression ,Aging ,Clinical Research ,Mental Health ,Good Health and Well Being ,Aged ,Female ,Heart Failure ,Hospitalization ,Humans ,Incidence ,Postmenopause ,Risk Factors ,Social Isolation ,Women's Health ,heart failure ,older adults ,social isolation ,women ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
Background The association of social isolation or lack of social network ties in older adults is unknown. This knowledge gap is important since the risk of heart failure (HF) and social isolation increase with age. The study examines whether social isolation is associated with incident HF in older women, and examines depressive symptoms as a potential mediator and age and race and ethnicity as effect modifiers. Methods and Results This study included 44 174 postmenopausal women of diverse race and ethnicity from the WHI (Women's Health Initiative) study who underwent annual assessment for HF adjudication from baseline enrollment (1993-1998) through 2018. We conducted a mediation analysis to examine depressive symptoms as a potential mediator and further examined effect modification by age and race and ethnicity. Incident HF requiring hospitalization was the main outcome. Social isolation was a composite variable based on marital/partner status, religious ties, and community ties. Depressive symptoms were assessed using CES-D (Center for Epidemiology Studies-Depression). Over a median follow-up of 15.0 years, we analyzed data from 36 457 women, and 2364 (6.5%) incident HF cases occurred; 2510 (6.9%) participants were socially isolated. In multivariable analyses adjusted for sociodemographic, behavioral, clinical, and general health/functioning; socially isolated women had a higher risk of incident HF than nonisolated women (HR, 1.23; 95% CI, 1.08-1.41). Adding depressive symptoms in the model did not change this association (HR, 1.22; 95% CI, 1.07-1.40). Neither race and ethnicity nor age moderated the association between social isolation and incident HF. Conclusions Socially isolated older women are at increased risk for developing HF, independent of traditional HF risk factors. Registration URL: http://www.clinicaltrials.gov; Unique identifier: NCT00000611.
- Published
- 2022
45. Evaluation of Social Isolation, Loneliness, and Cardiovascular Disease Among Older Women in the US
- Author
-
Golaszewski, Natalie M, LaCroix, Andrea Z, Godino, Job G, Allison, Matthew A, Manson, JoAnn E, King, Jennifer J, Weitlauf, Julie C, Bea, Jennifer W, Garcia, Lorena, Kroenke, Candyce H, Saquib, Nazmus, Cannell, Brad, Nguyen, Steve, and Bellettiere, John
- Subjects
Behavioral and Social Science ,Heart Disease - Coronary Heart Disease ,Aging ,Cardiovascular ,Heart Disease ,Prevention ,Clinical Research ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Cardiovascular Diseases ,Cohort Studies ,Female ,Humans ,Incidence ,Loneliness ,Postmenopause ,Prospective Studies ,Social Isolation ,Social Support ,United States ,Women's Health - Abstract
ImportanceSocial isolation and loneliness are increasing public health concerns and have been associated with increased risk of cardiovascular disease (CVD) among older adults.ObjectiveTo examine the associations of social isolation and loneliness with incident CVD in a large cohort of postmenopausal women and whether social support moderated these associations.Design, setting, and participantsThis prospective cohort study, conducted from March 2011 through March 2019, included community-living US women aged 65 to 99 years from the Women's Health Initiative Extension Study II who had no history of myocardial infarction, stroke, or coronary heart disease.ExposuresSocial isolation and loneliness were ascertained using validated questionnaires.Main outcomes and measuresThe main outcome was major CVD, which was physician adjudicated using medical records and included coronary heart disease, stroke, and death from CVD. Continuous scores of social isolation and loneliness were analyzed. Hazard ratios (HRs) and 95% CIs for CVD were calculated for women with high social isolation and loneliness scores (midpoint of the upper half of the distribution) vs those with low scores (midpoint of the lower half of the distribution) using multivariable Cox proportional hazards regression models adjusting for age, race and ethnicity, educational level, and depression and then adding relevant health behavior and health status variables. Questionnaire-assessed social support was tested as a potential effect modifier.ResultsAmong 57 825 women (mean [SD] age, 79.0 [6.1] years; 89.1% White), 1599 major CVD events occurred over 186 762 person-years. The HR for the association of high vs low social isolation scores with CVD was 1.18 (95% CI, 1.13-1.23), and the HR for the association of high vs low loneliness scores with CVD was 1.14 (95% CI, 1.10-1.18). The HRs after additional adjustment for health behaviors and health status were 1.08 (95% CI, 1.03-1.12; 8.0% higher risk) for social isolation and 1.05 (95% CI, 1.01-1.09; 5.0% higher risk) for loneliness. Women with both high social isolation and high loneliness scores had a 13.0% to 27.0% higher risk of incident CVD than did women with low social isolation and low loneliness scores. Social support was not a significant effect modifier of the associations (social isolation × social support: r, -0.18; P = .86; loneliness × social support: r, 0.78; P = .48).Conclusions and relevanceIn this cohort study, social isolation and loneliness were independently associated with modestly higher risk of CVD among postmenopausal women in the US, and women with both social isolation and loneliness had greater CVD risk than did those with either exposure alone. The findings suggest that these prevalent psychosocial processes merit increased attention for prevention of CVD in older women, particularly in the era of COVID-19.
- Published
- 2022
46. Broad clinical manifestations of polygenic risk for coronary artery disease in the Women’s Health Initiative
- Author
-
Clarke, Shoa L, Parham, Matthew, Lankester, Joanna, Shadyab, Aladdin H, Liu, Simin, Kooperberg, Charles, Manson, JoAnn E, Tcheandjieu, Catherine, and Assimes, Themistocles L
- Subjects
Biological Sciences ,Genetics ,Epidemiology ,Health Services and Systems ,Health Sciences ,Prevention ,Breast Cancer ,Atherosclerosis ,Lung ,Heart Disease ,Cancer ,Genetic Testing ,Clinical Research ,Aging ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Good Health and Well Being ,Cardiovascular genetics ,Medical genomics - Abstract
BackgroundThe genetic basis for coronary artery disease (CAD) risk is highly complex. Genome-wide polygenic risk scores (PRS) can help to quantify that risk, but the broader impacts of polygenic risk for CAD are not well characterized.MethodsWe measured polygenic risk for CAD using the meta genomic risk score, a previously validated genome-wide PRS, in a subset of genotyped participants from the Women's Health Initiative and applied a phenome-wide association study framework to assess associations between the PRS and a broad range of blood biomarkers, clinical measurements, and health outcomes.ResultsPolygenic risk for CAD is associated with a variety of biomarkers, clinical measurements, behaviors, and diagnoses related to traditional risk factors, as well as risk-enhancing factors. Analysis of adjudicated outcomes shows a graded association between atherosclerosis related outcomes, with the highest odds ratios being observed for the most severe manifestations of CAD. We find associations between increased polygenic risk for CAD and decreased risk for incident breast and lung cancer, with replication of the breast cancer finding in an external cohort. Genetic correlation and two-sample Mendelian randomization suggest that breast cancer association is likely due to horizontal pleiotropy, while the association with lung cancer may be causal.ConclusionPolygenic risk for CAD has broad clinical manifestations, reflected in biomarkers, clinical measurements, behaviors, and diagnoses. Some of these associations may represent direct pathways between genetic risk and CAD while others may reflect pleiotropic effects independent of CAD risk.
- Published
- 2022
47. Added Sugar, Sugar-Sweetened Beverages, and Artificially Sweetened Beverages and Risk of Cardiovascular Disease: Findings from the Women’s Health Initiative and a Network Meta-Analysis of Prospective Studies
- Author
-
Yang, Bo, Glenn, Andrea J, Liu, Qing, Madsen, Tracy, Allison, Matthew A, Shikany, James M, Manson, JoAnn E, Chan, Kei Hang Katie, Wu, Wen-Chih, Li, Jie, Liu, Simin, and Lo, Kenneth
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Nutrition and Dietetics ,Cardiovascular ,Heart Disease ,Heart Disease - Coronary Heart Disease ,Nutrition ,Brain Disorders ,Prevention ,Stroke ,Female ,Humans ,Artificially Sweetened Beverages ,Sugar-Sweetened Beverages ,Sweetening Agents ,Sugars ,Prospective Studies ,Cardiovascular Diseases ,Network Meta-Analysis ,Women's Health ,Coronary Disease ,Beverages ,added sugar ,sugar-sweetened beverages ,artificially sweetened beverages ,cardiovascular disease ,network meta-analysis ,prospective cohort ,Food Sciences ,Clinical sciences ,Nutrition and dietetics ,Public health - Abstract
Much remains unknown about the role of added sugar in relation to cardiovascular disease (CVD) and the relative contributions of sugar-sweetened beverages (SSB) or artificially sweetened beverages (ASB) to CVD risk. Among the 109,034 women who participated in Women's Health Initiative, we assessed average intakes of added sugar, SSB and ASB, and conducted Cox regression to estimate the hazard ratios (HRs) and their 95% confidence intervals for CVD risk. The consistency of findings was compared to a network meta-analysis of all available cohorts. During an average of 17.4 years of follow-up, 11,597 cases of total CVD (nonfatal myocardial infarction, coronary heart disease (CHD) death, stroke, coronary revascularization, and/or incident heart failure) were confirmed. Added sugar as % energy intake daily (%EAS) at ≥15.0% was positively associated with total CVD (HR = 1.08 [1.01, 1.15]) and CHD (HR = 1.20 [1.09, 1.32]). There was also a higher risk of total CVD associated with ≥1 serving of SSB intake per day (HR = 1.29 [1.17, 1.42]), CHD (1.35 [1.16, 1.57]), and total stroke (1.30 [1.10, 1.53]). Similarly, ASB intake was associated with an increased risk of CVD (1.14 [1.03, 1.26]) and stroke (1.24 [1.04, 1.48]). According to the network meta-analysis, there was a large amount of heterogeneity across studies, showing no consistent pattern implicating added sugar, ASB, or SSB in CVD outcomes. A diet containing %EAS ≥15.0% and consuming ≥1 serving of SSB or ASB may be associated with a higher CVD incidence. The relative contribution of added sugar, SSB, and ASB to CVD risk warrants further investigation.
- Published
- 2022
48. Heart rate variability and the risk of heart failure and its subtypes in post-menopausal women: The Women’s Health Initiative study
- Author
-
Baig, Muhammad, Moafi-Madani, Miremad, Qureshi, Reema, Roberts, Mary B, Allison, Matthew, Manson, JoAnn E, LaMonte, Michael J, Liu, Simin, and Eaton, Charles B
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Cardiovascular ,Heart Disease ,Clinical Research ,Aging ,Prevention ,Good Health and Well Being ,Humans ,Female ,Middle Aged ,Heart Rate ,Heart Failure ,Longitudinal Studies ,Calcium ,Postmenopause ,Stroke Volume ,Coronary Disease ,Women's Health ,Hormones ,General Science & Technology - Abstract
BackgroundLow heart rate variability (HRV), a measure of autonomic imbalance, is associated with increased risk of coronary heart disease (CHD) and heart failure (HF). However, its relationship with HF subtypes; heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) has not been studied prior.Methods and findingsWe conducted a longitudinal study in Women's Health Initiative study cohort to investigate the association of baseline quartiles of resting heart rate (rHR) and HRV measures; SDNN (SD of normal-to-normal RR interval) and RMSSD (root mean square of successive difference of RR interval) measured by twelve-lead electrocardiogram (ECG) on enrollment, with the risk of hospitalized HF and its subtypes. Total of 28,603 post-menopausal women, predominantly non-Hispanic whites (69%), with a mean (SD) age of 62.6 (7.1) years, free of baseline CHD and HF were included. In a fully adjusted cox-proportional hazards regression model which adjusted for age, race, BMI, alcohol intake, education, physical activity, hyperlipidemia, hypertension, left ventricular hypertrophy, use of beta-blocker, calcium-channel blocker, hormone therapy, and time-varying incident CHD, the hazard ratios of lowest quartile of HRV (Q1) with HF risk were significant (Q1 SDNN compared to Q4 SDNN: 1.22, 95% CI 1.07, 1.39; Q1 RMSSD compared to Q4 RMSSD: 1.17, 95% CI 1.02, 1.33). On subgroup analysis of HF subtypes, low HRV was associated with elevated HFpEF risk (Q1 vs Q4 SDNN: 1.22, 95% CI 1.02, 1.47) but not with HFrEF (Q1 vs Q4 SDNN: 1.19, 95% CI 0.95, 1.50; Q1 RMSSD: 1.13, 95% CI 0.90, 1.43).ConclusionLow HRV is associated with elevated overall hospitalized HF risk and HFpEF risk in post-menopausal women. Whether interventions to increase HRV through healthy lifestyle changes will decrease HF risk warrants further investigation.
- Published
- 2022
49. A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood
- Author
-
Kurniansyah, Nuzulul, Goodman, Matthew O, Kelly, Tanika N, Elfassy, Tali, Wiggins, Kerri L, Bis, Joshua C, Guo, Xiuqing, Palmas, Walter, Taylor, Kent D, Lin, Henry J, Haessler, Jeffrey, Gao, Yan, Shimbo, Daichi, Smith, Jennifer A, Yu, Bing, Feofanova, Elena V, Smit, Roelof AJ, Wang, Zhe, Hwang, Shih-Jen, Liu, Simin, Wassertheil-Smoller, Sylvia, Manson, JoAnn E, Lloyd-Jones, Donald M, Rich, Stephen S, Loos, Ruth JF, Redline, Susan, Correa, Adolfo, Kooperberg, Charles, Fornage, Myriam, Kaplan, Robert C, Psaty, Bruce M, Rotter, Jerome I, Arnett, Donna K, Morrison, Alanna C, Franceschini, Nora, Levy, Daniel, and Sofer, Tamar
- Subjects
Epidemiology ,Biological Sciences ,Health Sciences ,Genetics ,Hypertension ,Human Genome ,Prevention ,Cardiovascular ,Aging ,Aetiology ,2.1 Biological and endogenous factors ,Adult ,Diabetes Mellitus ,Type 2 ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Multifactorial Inheritance ,Prevalence ,Risk Factors ,NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium - Abstract
In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and progression. The PRS is trained using genome-wide association studies (GWAS) for systolic, diastolic blood pressure, and hypertension, respectively. For each trait, PRS is selected by optimizing the coefficient of variation (CV) across estimated effect sizes from multiple potential PRS using the same GWAS, after which the 3 trait-specific PRSs are combined via an unweighted sum called "PRSsum", forming the HTN-PRS. The HTN-PRS is associated with both prevalent and incident hypertension at 4-6 years of follow up. This association is further confirmed in age-stratified analysis. In an independent biobank of 40,201 individuals, the HTN-PRS is confirmed to be predictive of increased risk for coronary artery disease, ischemic stroke, type 2 diabetes, and chronic kidney disease.
- Published
- 2022
50. Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
- Author
-
DiCorpo, Daniel, Gaynor, Sheila M, Russell, Emily M, Westerman, Kenneth E, Raffield, Laura M, Majarian, Timothy D, Wu, Peitao, Sarnowski, Chloé, Highland, Heather M, Jackson, Anne, Hasbani, Natalie R, de Vries, Paul S, Brody, Jennifer A, Hidalgo, Bertha, Guo, Xiuqing, Perry, James A, O’Connell, Jeffrey R, Lent, Samantha, Montasser, May E, Cade, Brian E, Jain, Deepti, Wang, Heming, D’Oliveira Albanus, Ricardo, Varshney, Arushi, Yanek, Lisa R, Lange, Leslie, Palmer, Nicholette D, Almeida, Marcio, Peralta, Juan M, Aslibekyan, Stella, Baldridge, Abigail S, Bertoni, Alain G, Bielak, Lawrence F, Chen, Chung-Shiuan, Chen, Yii-Der Ida, Choi, Won Jung, Goodarzi, Mark O, Floyd, James S, Irvin, Marguerite R, Kalyani, Rita R, Kelly, Tanika N, Lee, Seonwook, Liu, Ching-Ti, Loesch, Douglas, Manson, JoAnn E, Minster, Ryan L, Naseri, Take, Pankow, James S, Rasmussen-Torvik, Laura J, Reiner, Alexander P, Reupena, Muagututi’a Sefuiva, Selvin, Elizabeth, Smith, Jennifer A, Weeks, Daniel E, Xu, Huichun, Yao, Jie, Zhao, Wei, Parker, Stephen, Alonso, Alvaro, Arnett, Donna K, Blangero, John, Boerwinkle, Eric, Correa, Adolfo, Cupples, L Adrienne, Curran, Joanne E, Duggirala, Ravindranath, He, Jiang, Heckbert, Susan R, Kardia, Sharon LR, Kim, Ryan W, Kooperberg, Charles, Liu, Simin, Mathias, Rasika A, McGarvey, Stephen T, Mitchell, Braxton D, Morrison, Alanna C, Peyser, Patricia A, Psaty, Bruce M, Redline, Susan, Shuldiner, Alan R, Taylor, Kent D, Vasan, Ramachandran S, Viaud-Martinez, Karine A, Florez, Jose C, Wilson, James G, Sladek, Robert, Rich, Stephen S, Rotter, Jerome I, Lin, Xihong, Dupuis, Josée, Meigs, James B, Wessel, Jennifer, and Manning, Alisa K
- Subjects
Biological Sciences ,Genetics ,Human Genome ,Biotechnology ,Diabetes ,2.1 Biological and endogenous factors ,Aetiology ,Metabolic and endocrine ,Good Health and Well Being ,Diabetes Mellitus ,Type 2 ,Fasting ,Glucose ,Humans ,Insulin ,National Heart ,Lung ,and Blood Institute (U.S.) ,Nerve Tissue Proteins ,Polymorphism ,Single Nucleotide ,Precision Medicine ,Receptors ,Immunologic ,United States ,Biological sciences ,Biomedical and clinical sciences - Abstract
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses from fifteen cohorts in NHLBI's Trans-Omics for Precision Medicine (TOPMed) program. Over 23,000 non-diabetic individuals from five race-ethnicities/populations (African, Asian, European, Hispanic and Samoan) were included. Eight variants were significantly associated with FG or FI across previously identified regions MTNR1B, G6PC2, GCK, GCKR and FOXA2. We additionally characterize suggestive associations with FG or FI near previously identified SLC30A8, TCF7L2, and ADCY5 regions as well as APOB, PTPRT, and ROBO1. Functional annotation resources including the Diabetes Epigenome Atlas were compiled for each signal (chromatin states, annotation principal components, and others) to elucidate variant-to-function hypotheses. We provide a catalog of nucleotide-resolution genomic variation spanning intergenic and intronic regions creating a foundation for future sequencing-based investigations of glycemic traits.
- Published
- 2022
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.