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The study's objective is to provide a rapid, simple, accurate, and cost-effective RP-HPLC assay technique for the simultaneous quantification of domperidone and cinnarizine in pharmaceutical bulk. Domperidone and cinnarizine in bulk have been successfully separated using this approach. Separation was carried out at 226 nm on a C18 SunfireTM (5 m, 250 mm 4.6 mm) analytical column using an Orthophosphoric acid and acetonitrile (60:40) mobile phase operating in isocratic elution mode at a flow rate of 1.0 ml/min. Domperidone had a retention time of 2.52 minutes, whereas Cinnarizine's was 5.18 minutes. PDA detection at 226 nm based on peak area with linear calibration curve in concentration ranges of 0-5 g/ml (0.9999) and 0-25 g/ml (0.9996) allowed for accurate quantitation of Domperidone and Cinnarizine, respectively. Domperidone and cinnarizine had LODs of 0.3325 and 0.615 g/ml, respectively. The suggested approach is well-suited for use in qualitycontrol labs for bulk quantitative analysis of the medications, both alone and in combination, since it is straightforward and quick while maintaining high accuracy and precision. [ABSTRACT FROM AUTHOR]

Plant bioactive are being used since the early days of medicinal discovery for their various therapeutic activities and are safer compared to modern medicines. According to World Health Organization (WHO), approximately 180,000 deaths from burns occur every year with the majority in countries. Recent years have witnessed significant advancements in this domain, with numerous plant bioactive and their various nanoformulations demonstrating promising preclinical burn wound healing activity and identified plant-based nanotechnology of various materials through some variations of cellular mechanisms. A comprehensive search was conducted on scientific databases like PubMed, Web of Science, ScienceDirect and Google Scholar to retrieve relevant literature on burn wound, plants, nano formulations and in vivo studies from 1990 to 2024. From a total of approximately 180 studies, 40 studies were screened out following the inclusion and exclusion criteria, which reported 40 different plants and plant extracts with their various nano-formulations (NFs) that were used against burn wounds preclinically. This study provides the current scenario of naturally-derived targeted therapy, exploring the impact of natural products on various nanotechnology in burn wound healing on a preclinical model. This comprehensive review provides the application of herbal nanoformulations (HBNF) for the treatment of burn wounds. Natural products and their derivatives may include many unidentified bioactive chemicals or untested nano-formulations that might be useful in today's medical toolbox. Mostly, nano-delivery system modulates the bioactive compound's effectiveness on burn wounds and increases compatibility by suppressing inflammation. However, their exploration remains incomplete, necessitating possible pathways and mechanisms of action using clinical models., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)