Search

Your search keyword '"Mancuso, Giovanni"' showing total 7 results
Start Over "Mancuso, Giovanni" Publication Year Range Last 3 years
7 results on '"Mancuso, Giovanni"'

1. Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium.

Author

Bartolini, Desirée, Arato, Iva, Mancuso, Francesca, Giustarini, Daniela, Bellucci, Catia, Vacca, Carmine, Aglietti, Maria Chiara, Stabile, Anna Maria, Rossi, Ranieri, Cruciani, Gabriele, Rende, Mario, Calafiore, Riccardo, Luca, Giovanni, and Galli, Francesco

Subjects
SERTOLI cells, NUCLEAR factor E2 related factor, TESTIS physiology, CADMIUM, MELATONIN
Abstract

Melatonin (MLT) is a cytoprotective agent holding potential to prevent cadmium (Cd) toxicity and its impact in testicular function and fertility. In this study, we explored such potential in porcine pre‐pubertal Sertoli cells (SCs). Cd toxicity resulted in impaired SC viability and function, abnormal cellular H2O2 generation and efflux, and induction of reductive stress by the upregulation of Nrf2 expression and activity, cystine uptake and glutathione biosynthesis, glutathione‐S‐transferase P (GSTP) expression, and protein glutathionylation inhibition. Cd toxicity also stimulated the activity of cellular kinases (MAPK‐ERK1/2 and Akt) and NFkB transcription factor, and cJun expression was increased. MLT produced a potent cytoprotective effect when co‐administered with Cd to SCs; its efficacy and the molecular mechanism behind its cytoprotective function varied according to Cd concentrations. However, a significant restoration of cell viability and function, and of H2O2 levels, was observed both at 5 and 10 μM Cd. Mechanistically, these effects of MLT were associated with a significant reduction of the Cd‐induced activation of Nrf2 and GSTP expression at all Cd concentrations. CAT and MAPK‐ERK1/2 activity upregulation was associated with these effects at 5 μM Cd, whereas glutathione biosynthesis and efflux were involved at 10 μM Cd together with an increased expression of the cystine transporter xCT, of cJun and Akt and NFkB activity. MLT protects SCs from Cd toxicity reducing its H2O2 generation and reductive stress effects. A reduced activity of Nrf2 and the modulation of other molecular players of MLT signaling, provide a mechanistic rational for the cytoprotective effect of this molecule in SCs. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

2. New Atrial Fibrillation Findings from University of Perugia Outlined (Reperfusion Therapies In Patients With Acute Ischaemic Stroke and Atrial Fibrillation: Data On Safety and Effectiveness From a Multi-centre Cohort Study).

Subjects
ATRIAL fibrillation, ISCHEMIC stroke, REPERFUSION, COHORT analysis, ARRHYTHMIA
Abstract

A study conducted by the University of Perugia in Italy examined the safety and effectiveness of reperfusion therapies in patients with acute ischemic stroke and atrial fibrillation (AF). The study found that patients who received reperfusion therapies had a significantly higher rate of good functional outcome and lower rates of mortality compared to those who underwent conservative treatment. The research analyzed data from two multicenter cohort studies and used multivariable logistic regression analysis and propensity score matching to compare treated and untreated patients. These findings provide valuable insights into the management of AF patients with acute ischemic stroke. [Extracted from the article]

Published
2024

3. Study Findings on Male Infertility Reported by Researchers at University of Perugia (Nickel oxide nanoparticles exposure as a risk factor for male infertility: "In vitro" effects on porcine pre-pubertal Sertoli cells).

Subjects
SERTOLI cells, MALE infertility, NICKEL oxide, RISK exposure, GENITALIA, TRANSITION metals
Abstract

Keywords: Emerging Technologies; Endocrine Cells; Genetics; Gonadal Hormones; Health and Medicine; Inhibins; Male Genital Diseases and Conditions; Male Infertility; Men's Health; Nanoparticles; Nanotechnology; Nickel; Reproductive Medicine; Risk and Prevention; Sertoli Cells; Testis; Transition Elements EN Emerging Technologies Endocrine Cells Genetics Gonadal Hormones Health and Medicine Inhibins Male Genital Diseases and Conditions Male Infertility Men's Health Nanoparticles Nanotechnology Nickel Reproductive Medicine Risk and Prevention Sertoli Cells Testis Transition Elements 1611 1611 1 04/17/23 20230421 NES 230421 2023 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on male infertility. For more information on this research see: Nickel oxide nanoparticles exposure as a risk factor for male infertility: "In vitro" effects on porcine pre-pubertal Sertoli cells. [Extracted from the article]

Published
2023

4. Utopia, Innovation, Tradition : Bruno Maderna's Cosmos

Author

Angela Ida De Benedictis and Angela Ida De Benedictis

Subjects
Music--History and criticism.--20th century
Abstract

This book, first collection of essays in English on Bruno Maderna, brings the reader closer to one of the greatest European composer and conductor of the last century.Utopia, Innovation, Tradition: Bruno Maderna's cosmos is the first collection of essays in English dedicated to one of the most multifaceted and interesting musical personalities of the 20th century, a protagonist in the development of new music after World War II. The various essays cover the most important aspects of Bruno Maderna's peculiar compositional approach and, thanks to innovative methodological perspectives based mainly on the study of archival materials, arrive at new and often completely unexpected interpretations.

Published
2023

5. Magic in Malta: Sellem Bin Al-Sheikh Mansur and the Roman Inquisition, 1605

Author

Dionysius A. Agius, Alexander Mallett, Catherine Rider, Dionysius A. Agius, Alexander Mallett, and Catherine Rider

Subjects
Trials (Witchcraft)--History--Malta--Sources, Magicians--Legal status, laws, etc.--History -, Muslims--Legal status, laws, etc.--History--, Inquisition--History--Malta--Sources
Abstract

In this volume, a microhistorical approach is employed to provide a transcription, translation, and case-study of the proceedings (written in Latin, Italian and Arabic) of the Roman Inquisition on Malta's 1605 trial of the ‘Moorish'slave Sellem Bin al-Sheikh Mansur, who was accused and found guilty of practising magic and teaching it to the local Christians. Through both a detailed commentary and individual case-studies, it assesses what these proceedings reflect about religion, society, and politics both on Malta and more widely across the Mediterranean in the early 17th century. In so doing, this inter- and multi-disciplinary project speaks to a wide range of subjects, including magic, Christian-Muslim relations, slavery, Maltese social history, Mediterranean history, and the Roman Inquisition. It will be of interest to both students and researchers who study any of these subjects, and will help demonstrate the richness and potential of the documents in the Maltese archives. With contributions by: Joan Abela, Dionisius A. Agius, Paul Auchterlonie, Jonathan Barry, Charles Burnett, Frans Ciappara, Pierre Lory, Alex Malett, Ian Netton, Catherine R. Rider, Liana Saif

Published
2022

6. Study Findings on Male Infertility Reported by Researchers at University of Perugia (Nickel oxide nanoparticles exposure as a risk factor for male infertility: 'In vitro' effects on porcine pre-pubertal Sertoli cells)

Subjects
Infertility, Male -- Risk factors -- Research, Puberty -- Reports -- Research, Nickel -- Research -- Reports, Nanoparticles -- Research -- Reports, Reproductive organs -- Research -- Reports, Health
Abstract

2023 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on male infertility. According to news reporting originating from [...]

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results