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Your search keyword '"Maligres, Peter E."' showing total 5 results
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5 results on '"Maligres, Peter E."'

2. Selective Synthesis of N6,3′,5′-Tripivaloyladenosine via Dynamic Kinetic Crystallization and Regioselective Preparation of Pivalated 2′-Deoxy-2′-fluoroarabinoadenosines

Author

Maligres, Peter E., Song, Zhiguo Jake, Chen, Lu, Kosjek, Birgit, Ad, Omer, and Chung, Cheol K.

Abstract

A four chemical step route to 2′-deoxy-2′-fluoro-N6,3′-dipivaloylarabinoadenosine and 2′-deoxy-2′-fluoro-N6-pivaloylarabinoadenosine from adenosine was developed for the preparation of ulevostinag in our STING (Stimulator of Interferon Genes) program. This 4-step route is based on the selective protection of adenosine with a dynamic kinetic crystallization of the desired N6,3′,5′-tripivaloyladenosine. This is followed by activation of the 2′-alcohol as its triflate without pivalate migration. Subsequently, the triflate is displaced with fluoride under mild conditions. Selective deprotection of the esters can give a variety of mono- and diacylated products including the 3′- or 5′-protected 2′-fluoroarabinonucleoside in the presence of the N6-pivalamide.

Published
2024
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3. Manufacturing Process Development for Uprifosbuvir (MK-3682): A Green and Sustainable Process for Preparing Penultimate 2′-Deoxy-α-2′-Chloro-β-2′-Methyluridine

Author

Maligres, Peter E., primary, Peng, Feng, additional, Calabria, Ralph, additional, Campeau, Louis-Charles, additional, Chen, Wenyong, additional, Dormer, Peter G., additional, Green, Meredith, additional, He, Cyndi Qixin, additional, Hyde, Alan M., additional, Klapars, Artis, additional, Larsen, Mona Utne, additional, Limanto, John, additional, Liu, Guiquan, additional, Liu, Yizhou, additional, Moment, Aaron, additional, Nowak, Timothy, additional, Ruck, Rebecca T., additional, Shevlin, Michael, additional, Song, Zhiguo Jake, additional, Tan, Lushi, additional, Tong, Weidong, additional, Waldman, Jacob H., additional, Ye, Honglin, additional, Zhao, Ralph, additional, Zhou, George, additional, Zompa, Michael A., additional, and Zultanski, Susan L., additional

Published
2022
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4. Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454

Author

Benkovics, Tamas, primary, Peng, Feng, additional, Phillips, Eric M., additional, An, Chihui, additional, Bade, Rachel S., additional, Chung, Cheol K., additional, Dance, Zachary E. X., additional, Fier, Patrick S., additional, Forstater, Jacob H., additional, Liu, Zhijian, additional, Liu, Zhuqing, additional, Maligres, Peter E., additional, Marshall, Nicholas M., additional, Salehi Marzijarani, Nastaran, additional, McIntosh, John A., additional, Miller, Steven P., additional, Moore, Jeffrey C., additional, Neel, Andrew J., additional, Obligacion, Jennifer V., additional, Pan, Weilan, additional, Pirnot, Michael T., additional, Poirier, Marc, additional, Reibarkh, Mikhail, additional, Sherry, Benjamin D., additional, Song, Zhiguo Jake, additional, Tan, Lushi, additional, Turnbull, Ben W. H., additional, Verma, Deeptak, additional, Waldman, Jacob H., additional, Wang, Lu, additional, Wang, Tao, additional, Winston, Matthew S., additional, and Xu, Feng, additional

Published
2022
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