10 results on '"Maharaj, Dipnarine"'
Search Results
2. Contributors
- Author
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Abreu, Maria M., primary, Adusumilli, Prasad S., additional, Badie, Behnam, additional, Basar, Rafet, additional, Bellis, Rebecca, additional, Blasberg, Ronald, additional, Breznik, Barbara, additional, Chaurasiya, Shyambabu, additional, Chen, Po-Chun, additional, Choong, Kevin, additional, Chovatiya, Nishant, additional, Daher, May, additional, Deshpande, Supriya, additional, Feldman, Lisa, additional, Folsom, Timothy D., additional, Fong, Christina, additional, Fong, Yuman, additional, Gouvea, Jacqueline, additional, Habič, Anamarija, additional, Jewett, Anahid, additional, Katz, Sharyn I., additional, Kaur, Kawaljit, additional, Ko, Meng-Wei, additional, Kos, Janko, additional, Lee, Derek, additional, Li, Zhe, additional, Lou, Emil, additional, Maharaj, Dipnarine, additional, Mahuron, Kelly, additional, Majc, Bernarda, additional, Matosevic, Sandro, additional, Moriarity, Branden S., additional, Murad, John P., additional, Navin, Ishwar, additional, Novak, Metka, additional, Parihar, Robin, additional, Park, Anthony K., additional, Polineni, Vineet, additional, Ponomarev, Vladimir, additional, Priceman, Saul J., additional, Rafei, Hind, additional, Rand, Jamie, additional, Rezvani, Katayoun, additional, Rivière, Isabelle, additional, Roshkovan, Leonid, additional, Sadeghi, Saeed, additional, Saini, Jasmeen, additional, Senjor, Emanuela, additional, Serganova, Inna, additional, Starr, Timothy K., additional, Turnsek, Tamara Lah, additional, Volpe, Alessia, additional, Wang, Xiuyan, additional, Webber, Beau R., additional, Wong, Paul, additional, Woo, Yanghee, additional, Wu, Jennifer, additional, Yang, Lili, additional, Yuan, Yuan, additional, Zeng, Samuel, additional, and Zhu, Amy, additional
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- 2023
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3. Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation
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Phelan, Rachel, Im, Annie, Hunter, Rebecca L., Inamoto, Yoshihiro, Lupo-Stanghellini, Maria Teresa, Rovo, Alicia, Badawy, Sherif M., Burns, Linda, Eissa, Hesham, Murthy, Hemant S., Prasad, Pinki, Sharma, Akshay, Suelzer, Elizabeth, Agrawal, Vaibhav, Aljurf, Mahmoud, Baker, Karen, Basak, Grzegorz W., Buchbinder, David, DeFilipp, Zachariah, Grkovic, Lana Desnica, Dias, Ajoy, Einsele, Hermann, Eisenberg, Michael L., Epperla, Narendranath, Farhadfar, Nosha, Flatau, Arthur, Gale, Robert Peter, Greinix, Hildegard, Hamilton, Betty K., Hashmi, Shahrukh, Hematti, Peiman, Jamani, Kareem, Maharaj, Dipnarine, Murray, John, Naik, Seema, Nathan, Sunita, Pavletic, Steven, Peric, Zinaida, Pulanic, Drazen, Ross, Richard, Salonia, Andrea, Sanchez-Ortega, Isabel, Savani, Bipin N., Schechter, Tal, Shah, Ami J., Smith, Stephanie M., Snowden, John A., Steinberg, Amir, Tremblay, Douglas, Vij, Sarah C., Walker, Lauren, Wolff, Daniel, Yared, Jean A., Schoemans, Hélène, and Tichelli, André
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- 2022
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4. The potential role of cytotoxic immune effectors in ALS; A longitudinal case study comparing the patient to genetically identical healthy twin
- Author
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Kaur, Kawaljit, primary, Chen, Po-Chun, additional, Ko, Meng-Wei, additional, Huerta-Yepez, Sara, additional, Maharaj, Dipnarine, additional, and Jewett, Anahid, additional
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- 2023
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5. Successes and challenges of taming the beast; Cytotoxic immune effectors in ALS
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Kaur, Kawaljit, primary, Chen, Po-Chun, additional, Ko, Meng-Wei, additional, Mei, Ao, additional, Huerta-Yepez, Sara, additional, Maharaj, Dipnarine, additional, Malarkannan, Subramaniam, additional, and Jewett, Anahid, additional
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- 2023
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6. Male-Specific Late Effects in Adult Hematopoietic Cell Transplantation Recipients: A Systematic Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation
- Author
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Phelan, Rachel, primary, Im, Annie, additional, Hunter, Rebecca L., additional, Inamoto, Yoshihiro, additional, Lupo-Stanghellini, Maria Teresa, additional, Rovo, Alicia, additional, Badawy, Sherif M., additional, Burns, Linda, additional, Eissa, Hesham, additional, Murthy, Hemant S., additional, Prasad, Pinki, additional, Sharma, Akshay, additional, Suelzer, Elizabeth, additional, Agrawal, Vaibhav, additional, Aljurf, Mahmoud, additional, Baker, Karen, additional, Basak, Grzegorz W., additional, Buchbinder, David, additional, DeFilipp, Zachariah, additional, Grkovic, Lana Desnica, additional, Dias, Ajoy, additional, Einsele, Hermann, additional, Eisenberg, Michael L., additional, Epperla, Narendranath, additional, Farhadfar, Nosha, additional, Flatau, Arthur, additional, Gale, Robert Peter, additional, Greinix, Hildegard, additional, Hamilton, Betty K., additional, Hashmi, Shahrukh, additional, Hematti, Peiman, additional, Jamani, Kareem, additional, Maharaj, Dipnarine, additional, Murray, John, additional, Naik, Seema, additional, Nathan, Sunita, additional, Pavletic, Steven, additional, Peric, Zinaida, additional, Pulanic, Drazen, additional, Ross, Richard, additional, Salonia, Andrea, additional, Sanchez-Ortega, Isabel, additional, Savani, Bipin N., additional, Schechter, Tal, additional, Shah, Ami J., additional, Smith, Stephanie M., additional, Snowden, John A., additional, Steinberg, Amir, additional, Tremblay, Douglas, additional, Vij, Sarah C., additional, Walker, Lauren, additional, Wolff, Daniel, additional, Yared, Jean A., additional, Schoemans, Hélène, additional, and Tichelli, André, additional
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- 2022
- Full Text
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7. Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation
- Author
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Shahrukh K. Hashmi, Jean A. Yared, Arthur Flatau, Sunita Nathan, Yoshihiro Inamoto, Dipnarine Maharaj, Bipin N. Savani, Lana Desnica Grkovic, André Tichelli, Mahmoud Aljurf, Stephanie M. Smith, Rachel Phelan, Hélène Schoemans, Richard J. Ross, Lauren M. Walker, Robert Peter Gale, Zachariah DeFilipp, Daniel Wolff, Karen C. Baker, Hesham Eissa, Sherif M. Badawy, Hermann Einsele, Alicia Rovó, Isabel Sanchez-Ortega, Maria Teresa Lupo-Stanghellini, Douglas Tremblay, Michael L. Eisenberg, Hildegard T. Greinix, Hemant S. Murthy, Annie Im, Amir Steinberg, Grzegorz W. Basak, Peiman Hematti, Tal Schechter, Andrea Salonia, David Buchbinder, Elizabeth M. Suelzer, Vaibhav Agrawal, Steven Pavletic, Kareem Jamani, John Murray, Seema Naik, Ami J. Shah, Sarah C. Vij, Akshay Sharma, Rebecca Hunter, Zinaida Peric, Narendranath Epperla, Linda J. Burns, Ajoy Dias, Nosha Farhadfar, Pinki Prasad, John A. Snowden, Betty K. Hamilton, D. Pulanić, Phelan, Rachel, Im, Annie, Hunter, Rebecca L, Inamoto, Yoshihiro, Lupo-Stanghellini, Maria Teresa, Rovo, Alicia, Badawy, Sherif M, Burns, Linda, Eissa, Hesham, Murthy, Hemant S, Prasad, Pinki, Sharma, Akshay, Suelzer, Elizabeth, Agrawal, Vaibhav, Aljurf, Mahmoud, Baker, Karen, Basak, Grzegorz W, Buchbinder, David, Defilipp, Zachariah, Grkovic, Lana Desnica, Dias, Ajoy, Einsele, Hermann, Eisenberg, Michael L, Epperla, Narendranath, Farhadfar, Nosha, Flatau, Arthur, Gale, Robert Peter, Greinix, Hildegard, Hamilton, Betty K, Hashmi, Shahrukh, Hematti, Peiman, Jamani, Kareem, Maharaj, Dipnarine, Murray, John, Naik, Seema, Nathan, Sunita, Pavletic, Steven, Peric, Zinaida, Pulanic, Drazen, Ross, Richard, Salonia, Andrea, Sanchez-Ortega, Isabel, Savani, Bipin N, Schechter, Tal, Shah, Ami J, Smith, Stephanie M, Snowden, John A, Steinberg, Amir, Tremblay, Dougla, Vij, Sarah C, Walker, Lauren, Wolff, Daniel, Yared, Jean A, Schoemans, Hélène, and Tichelli, André
- Subjects
Adult ,Male ,Infertility ,medicine.medical_specialty ,Evidence-based practice ,Sexual Dysfunction ,Survivorship ,Late effects ,Male-specific ,Hematopoietic cell transplantation ,Genital ,Chronic graft-versus-host disease ,Hypogonadism ,Sexual dysfunction ,Subsequent malignancies ,Population ,Graft vs Host Disease ,610 Medicine & health ,Disease ,Article ,Testicular Neoplasms ,Quality of life ,Bone Marrow ,medicine ,Humans ,Immunology and Allergy ,Hematopoietic Cell Transplantation ,Intensive care medicine ,education ,Late Effects ,Reproductive health ,education.field_of_study ,Subsequent Malignancies ,Transplantation ,business.industry ,Male-Specific ,Hematopoietic Stem Cell Transplantation ,Cell Biology ,Hematology ,medicine.disease ,Transplant Recipients ,surgical procedures, operative ,Genital Chronic Graft-versus-Host Disease ,Disease Progression ,Quality of Life ,Molecular Medicine ,Female ,medicine.symptom ,business - Abstract
Background : Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GvHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies, such as prostate, penile, and testicular cancer. They may be closely intertwined and cause prolonged morbidity and decreased quality of life after HCT. Objective : Here, we provide a systematic review of male-specific late effects in a collaboration between transplant physicians, endocrinologists, urologists, dermatologists, and sexual health professionals through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research, and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Study Design : We utilized systematic review methodology to summarize incidence, risk factors, screening, prevention and treatment of these complications and provide consensus evidence-based recommendations for clinical practice and future research. Results : Most of the evidence regarding male GvHD is still based on limited data, precluding strong therapeutic recommendations. We therefore recommend to systematically screen for male genital GvHD regularly and report it to large registries to allow for a better understanding. Future research should also address treatment since little published evidence is available to date. Male-specific endocrine consequences of HCT include hypogonadism which may also affect bone health. Since the evidence is scarce, current recommendations for hormone substitution and/or bone health treatment are based on similar principles as for the general population. Following HCT, sexual health decreases and this topic should be addressed at regular intervals. Future studies should focus on interventional strategies to address sexual dysfunction. Infertility remains prevalent in patients having undergone myeloablative conditioning, which warrants offering sperm preservation in all HCT candidates. Most studies on fertility rely on descriptive registry analysis and surveys, hence the importance of reporting post-HCT conception data to large registries. Although the quality of evidence is low, the development of cancer in male genital organs does not seem more prevalent than in the general population; however, subsequent malignancies in general seem to be more prevalent in males than females, and special attention should be given to skin and oral mucosa. Conclusion : Male-specific late effects, probably more under-reported than female-specific complications, should be systematically considered during the regular follow-up visits of male survivors who have undergone HCT. Care of patients with male-specific late effects warrants close collaboration between transplant physicians and specialists from other involved disciplines. Future research should be directed towards better data collection on male-specific late effects and on studies about the interrelationship between these late effects, to allow the development of evidence based effective management practices.
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- 2022
8. The Potential Role of Cytotoxic Immune Effectors in Amyotrophic Lateral Sclerosis (ALS); A Longitudinal Case Study Comparing Patients with Genetically Identical Healthy Twin.
- Author
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Kaur K, Chen PC, Ko MW, Huerta-Yepez S, Maharaj D, and Jewett A
- Abstract
Amyotrophic lateral sclerosis (ALS) is an auto-immune neurodegenerative disorder affecting the motor-neurons. The causes of ALS are heterogeneous, and are only partially understood to date. We studied percentage and function of immune cell subsets in particular natural killer (NK) and CD8+ T cells in an ALS patient and compared the results to those obtained from his genetically identical healthy twin in a longitudinal study. We found several basic mechanisms which were potentially involved in the disease induction and progression. Our findings demonstrate that ALS patient's peripheral blood contained higher NK and B cells and, lower T cell percentages compared with the healthy twin brother's peripheral blood. Significantly increased interferon-gamma secretion by anti-CD3/28 monoclonal antibody-treated peripheral blood mononuclear cells, and sorted CD8+ T cells were observed in the ALS patient, suggesting that hyper-responsiveness of T cell compartment could be a potential mechanism of ALS progression. Significant increase in NK cell function due to genetic mutations in ALS associated genes may partly be responsible for the increase expansion and function of CD8+ T cells with effector/memory phenotype, in addition to direct activation and expansion of antigen specific T cells by such mutations. Weekly N-acetyl cysteine infusion to block cell death in patient in addition to a number of other therapies listed in this paper were not effective, and even though the treatments might have extended the patient's life, it was not curative. Therefore, activated CD8+ T and NK cells are likely cells targeting motor neurons in the patient, and strategies should be designed to decrease the aggressive nature of these cells to achieve longer lasting therapeutic benefits.
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- 2023
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9. Successes and Challenges in Taming the Beast: Cytotoxic Immune Effectors in Amyotrophic Lateral Sclerosis.
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Kaur K, Chen PC, Ko MW, Mei A, Huerta-Yepez S, Maharaj D, Malarkannan S, and Jewett A
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- Humans, Motor Neurons metabolism, Motor Neurons pathology, Superoxide Dismutase-1 genetics, Superoxide Dismutase-1 metabolism, Superoxide Dismutase-1 pharmacology, Cytokines metabolism, Amyotrophic Lateral Sclerosis genetics, Amyotrophic Lateral Sclerosis therapy, Amyotrophic Lateral Sclerosis metabolism
- Abstract
Amyotrophic lateral sclerosis (ALS) is a neurological disease characterized by the progressive loss of motor neurons in the brain and spinal cord. No effective therapeutic strategies have been established thus far, and therefore there is a significant unmet need for effective therapeutics to arrest the disease and reverse the pathologies induced by it. Although the cause of ALS is not well-defined, it appears to be heterogenous. Currently over 20 genes have been found to be associated with ALS. Family history can only be found in 10% of ALS patients, but in the remaining 90% no association with family history is found. The most common genetic causes are expansion in the C9orf72 gene and mutations in superoxide dismutase 1, TDP-43, and FUS. In our recent study, we also found mutations in TDP43 and FUS in ALS patients. To understand the pathogenesis of the disease, we set ourselves the task of analyzing the phenotype and function of all key immune effectors in ALS patients, comparing them with either a genetically healthy twin or healthy individuals. Our study demonstrated a significant increase in functional activation of NK and CD8+ T cytotoxic immune effectors and release of significant IFN-γ not only by the effector cells but also in the serum of ALS patients. Longitudinal analysis of CD8+ T cell-mediated IFN-γ secretion from ALS patients demonstrated continued and sustained increase in IFN-γ secretion with periods of decrease which coincided with certain treatments; however, the effects were largely short-lived. N-acetyl cysteine (NAC), one of the treatments used, is known to block cell death; however, even though such treatment was able to block most of the proinflammatory cytokines, chemokines, and growth factor release, it was not able to block IFN-γ and TNF-α, the two cytokines we had demonstrated previously to induce differentiation of the cells. In this review, we discuss the contribution of cytotoxic effector cells, especially primary NK cells, supercharged NK cells (sNK), and the contribution of sNK cells in expansion and functional activation of CD8+ T cells to memory/effector T cells in the pathogenesis of ALS. Potential new targeted therapeutic strategies are also discussed.
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- 2023
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10. Personalized Precision Immunotherapy for Amyotrophic Lateral Sclerosis (ALS).
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Maharaj D, Kaur K, Saltese A, and Gouvea J
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- Humans, Immunotherapy, Brain, Cytokines, Inflammation, Amyotrophic Lateral Sclerosis genetics, Amyotrophic Lateral Sclerosis therapy
- Abstract
Neurological syndrome amyotrophic lateral sclerosis (ALS) affects motor neurons and is characterized by progressive motor neuron loss in the brain and spinal cord. ALS starts with mainly focal onset but when the disease progresses, it spreads to different parts of the body, with survival limits of 2-5 years after disease initiation. To date, only supportive care is provided for ALS patients, and no effective treatment or cure has been discovered. This review is focused on clinical and immunological aspects of ALS patients, based on our case studies, and we discuss the treatment we have provided to those patients based on a detailed evaluation of their peripheral blood immune cells and blood-derived serum secreted factors, cytokines, chemokines and growth factors. We show that using a personalized approach of low dose immunotherapy there is an improvement in the effects on inflammation and immunological dysfunction.
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- 2023
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