Search

Your search keyword '"Magnani, Giulia"' showing total 36 results
Start Over Author "Magnani, Giulia" Publication Year Range Last 3 years
36 results on '"Magnani, Giulia"'

5. Precipitating factors in patients with spontaneous coronary artery dissection: Clinical, laboratoristic and prognostic implications

Author

Gurgoglione, Filippo Luca, Rizzello, Davide, Giacalone, Rossella, Ferretti, Marco, Vezzani, Antonella, Pfleiderer, Bettina, Pelà, Giovanna, De Panfilis, Chiara, Cattabiani, Maria Alberta, Benatti, Giorgio, Tadonio, Iacopo, Grassi, Francesca, Magnani, Giulia, Noni, Manjola, Cancellara, Martina, Nicolini, Francesco, Ardissino, Diego, Vignali, Luigi, Niccoli, Giampaolo, and Solinas, Emilia

Published
2023
Full Text
View/download PDF

7. Cardiovascular Disease from Pathophysiology to Risk Estimation: Is Inflammation Estimated through Perivascular Attenuation on Computed Tomography the Key?

Author

Tuttolomondo, Domenico, primary, Niccoli, Giampaolo, additional, Martini, Chiara, additional, D’Ascenzo, Fabrizio, additional, De Filippo, Ovidio, additional, Nicolini, Francesco, additional, Formica, Francesco, additional, Carino, Davide, additional, Gurgoglione, Filippo Luca, additional, Denegri, Andrea, additional, Magnani, Giulia, additional, Vignali, Luigi, additional, De Filippo, Massimo, additional, Sverzellati, Nicola, additional, Ticinesi, Andrea, additional, Bergamaschi, Luca, additional, Pizzi, Carmine, additional, Gherbesi, Elisa, additional, Suma, Sergio, additional, and Gaibazzi, Nicola, additional

Published
2024
Full Text
View/download PDF

8. Microvascular complications identify a specific coronary atherosclerotic phenotype in patients with type 2 diabetes mellitus

Author

Montone, Rocco A., Pitocco, Dario, Gurgoglione, Filippo Luca, Rinaldi, Riccardo, Del Buono, Marco Giuseppe, Camilli, Massimiliano, Rizzi, Alessandro, Tartaglione, Linda, Rizzo, Gaetano Emanuele, Di Leo, Mauro, Flex, Andrea, Russo, Michele, Liuzzo, Giovanna, Magnani, Giulia, Bonadonna, Riccardo C., Ardissino, Diego, Crea, Filippo, and Niccoli, Giampaolo

Published
2022
Full Text
View/download PDF

9. Ischemic-hemorrhagic balance in diabetic and non-diabetic patients after acute coronary syndrome

Author

Domínguez-Rodríguez, Luis Manuel, Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Cespón-Fernández, María, Melendo-Viu, María, D’Ascenzo, Fabrizio, Kinnaird, Tim, Ariza-Solé, Albert, Manzano-Fernández, Sergio, Templin, Christian, Velicki, Lazar, Xanthopoulou, Ioanna, Cerrato, Enrico, Quadri, Giorgio, Rognoni, Andrea, Boccuzzi, Giacome, Montabone, Andrea, Taha, Salma, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Flores-Blanco, Pedro, Garay, Alberto, Varbella, Ferdinando, Tommassini, Francesco, Gallo, Diego, Morbiducci, Umberto, Domínguez-Rodríguez, Alberto, Valdés, Mariano, Cequier, Ángel, Gaita, Fiorenzo, Alexopoulos, Dimitrios, and Íñiguez-Romo, Andrés

Published
2022
Full Text
View/download PDF

10. Long-term outcomes of early-onset myocardial infarction with non-obstructive coronary artery disease (MINOCA)

Author

Magnani, Giulia, Bricoli, Serena, Ardissino, Maddalena, Maglietta, Giuseppe, Nelson, Adam, Malagoli Tagliazucchi, Guidantonio, Disisto, Caterina, Celli, Patrizia, Ferrario, Maurizio, Canosi, Umberto, Cernetti, Carlo, Negri, Francesco, Merlini, Piera Angelica, Tubaro, Marco, Berzuini, Carlo, Manzalini, Chiara, Ignone, Gianfranco, Campana, Carlo, Moschini, Luigi, Ponte, Elisabetta, Pozzi, Roberto, Fetiveau, Raffaela, Buratti, Silvia, Paraboschi, Elvezia, Asselta, Rosanna, Botti, Andrea, Tuttolomondo, Domenico, Barocelli, Federico, Biagi, Andrea, Bonura, Rosario, Moccetti, Tiziano, Crocamo, Antonio, Benatti, Giorgio, Paoli, Giorgia, Solinas, Emilia, Notarangelo, Maria Francesca, Moscarella, Elisabetta, Calabrò, Paolo, Duga, Stefano, Niccoli, Giampaolo, and Ardissino, Diego

Published
2022
Full Text
View/download PDF

11. Evaluation of a Voltametric E-Tongue Combined with Data Preprocessing for Fast and Effective Machine Learning-Based Classification of Tomato Purées by Cultivar.

Author

Magnani, Giulia, Giliberti, Chiara, Errico, Davide, Stighezza, Mattia, Fortunati, Simone, Mattarozzi, Monica, Boni, Andrea, Bianchi, Valentina, Giannetto, Marco, De Munari, Ilaria, Cagnoni, Stefano, and Careri, Maria

Subjects
*FISHER discriminant analysis, *GOLD nanoparticles, *TOMATOES, *COPPER, *CARBON electrodes, *SENSOR arrays, *CULTIVARS
Abstract

The potential of a voltametric E-tongue coupled with a custom data pre-processing stage to improve the performance of machine learning techniques for rapid discrimination of tomato purées between cultivars of different economic value has been investigated. To this aim, a sensor array with screen-printed carbon electrodes modified with gold nanoparticles (GNP), copper nanoparticles (CNP) and bulk gold subsequently modified with poly(3,4-ethylenedioxythiophene) (PEDOT), was developed to acquire data to be transformed by a custom pre-processing pipeline and then processed by a set of commonly used classifiers. The GNP and CNP-modified electrodes, selected based on their sensitivity to soluble monosaccharides, demonstrated good ability in discriminating samples of different cultivars. Among the different data analysis methods tested, Linear Discriminant Analysis (LDA) proved to be particularly suitable, obtaining an average F1 score of 99.26%. The pre-processing stage was beneficial in reducing the number of input features, decreasing the computational cost, i.e., the number of computing operations to be performed, of the entire method and aiding future cost-efficient hardware implementation. These findings proved that coupling the multi-sensing platform featuring properly modified sensors with the custom pre-processing method developed and LDA provided an optimal tradeoff between analytical problem solving and reliable chemical information, as well as accuracy and computational complexity. These results can be preliminary to the design of hardware solutions that could be embedded into low-cost portable devices. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. Author Correction: Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction

Author

Galli, Mattia, primary, Niccoli, Giampaolo, additional, De Maria, Gianluigi, additional, Brugaletta, Salvatore, additional, Montone, Rocco A., additional, Vergallo, Rocco, additional, Benenati, Stefano, additional, Magnani, Giulia, additional, D’Amario, Domenico, additional, Porto, Italo, additional, Burzotta, Francesco, additional, Abbate, Antonio, additional, Angiolillo, Dominick J., additional, and Crea, Filippo, additional

Published
2023
Full Text
View/download PDF

14. Timing of Complete Revascularization with Multivessel PCI for Myocardial Infarction

Author

Stähli, Barbara E., primary, Varbella, Ferdinando, additional, Linke, Axel, additional, Schwarz, Bettina, additional, Felix, Stephan B., additional, Seiffert, Moritz, additional, Kesterke, Rahel, additional, Nordbeck, Peter, additional, Witzenbichler, Bernhard, additional, Lang, Irene M., additional, Kessler, Mirjam, additional, Valina, Christian, additional, Dibra, Alban, additional, Rohla, Miklos, additional, Moccetti, Marco, additional, Vercellino, Matteo, additional, Gaede, Luise, additional, Bott-Flügel, Lorenz, additional, Jakob, Philipp, additional, Stehli, Julia, additional, Candreva, Alessandro, additional, Templin, Christian, additional, Schindler, Matthias, additional, Wischnewsky, Manfred, additional, Zanda, Greca, additional, Quadri, Giorgio, additional, Mangner, Norman, additional, Toma, Aurel, additional, Magnani, Giulia, additional, Clemmensen, Peter, additional, Lüscher, Thomas F., additional, Münzel, Thomas, additional, Schulze, P. Christian, additional, Laugwitz, Karl-Ludwig, additional, Rottbauer, Wolfgang, additional, Huber, Kurt, additional, Neumann, Franz-Josef, additional, Schneider, Steffen, additional, Weidinger, Franz, additional, Achenbach, Stephan, additional, Richardt, Gert, additional, Kastrati, Adnan, additional, Ford, Ian, additional, Maier, Willibald, additional, and Ruschitzka, Frank, additional

Published
2023
Full Text
View/download PDF

15. Microvascular Complications Are Associated With Coronary Collateralization in Type 2 Diabetes and Chronic Occlusion.

Author

Gurgoglione, Filippo Luca, Pitocco, Dario, Montone, Rocco A, Rinaldi, Riccardo, Bonadonna, Riccardo C, Magnani, Giulia, Calvieri, Camilla, Solinas, Emilia, Rizzi, Alessandro, Tartaglione, Linda, Flex, Andrea, Viti, Luca, Trani, Carlo, Ardissino, Diego, Crea, Filippo, and Niccoli, Giampaolo

Subjects
TYPE 2 diabetes, CHRONIC total occlusion, CORONARY angiography
Abstract

Context Coronary collateral (CC) vessel development appears to be protective with regard to adverse cardiovascular events and survival in patients with coronary chronic total occlusion (CTO). The influence of type 2 diabetes mellitus (T2DM) on CC growth has been controversial. In particular, the role of diabetic microvascular complications (DMC) in determining coronary collateralization has not been elucidated. Objective To investigate whether patients with DMC presented differences in CC vessel presence and grading as compared with patients without DMC. Methods We conducted a single-center observational study, including consecutive T2DM patients, without previous cardiovascular history, undergoing a clinically indicated coronary angiography for chronic coronary syndrome (CCS) and angiographic evidence of at least one CTO. Patients were subdivided into 2 study groups according to the presence/absence of at least one DMC (neuropathy, nephropathy, or retinopathy). The presence and grading of angiographically visible CC development from the patent vessels to the occluded artery were assessed using the Rentrop classification. Results We enrolled 157 patients (mean age 68.6 ± 9.8 years; 120 [76.4%] men). Patients with DMC (75 [47.8%]) had a higher prevalence of CC (69 [92.0%] vs 62 [75.6%], P =.006) and high-grade CC (55 [73.3%] vs 39 [47.6%], P =.001) compared with those without, and we found a positive association between the number of DMC in each patient and the prevalence of high-grade CC. Conclusion Among T2DM patients with coronary CTO, the presence of DMC was associated with a high CC development. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Dual Antiplatelet Therapy or Antiplatelet Plus Anticoagulant Therapy in Patients with Peripheral and Chronic Coronary Artery Disease: An Updated Review

Author

Magnani, Giulia, primary, Denegri, Andrea, additional, Gurgoglione, Filippo Luca, additional, Barocelli, Federico, additional, Indrigo, Elia, additional, Catellani, Davide, additional, Signoretta, Gianluca, additional, Bettella, Alberto, additional, Tuttolomondo, Domenico, additional, Solinas, Emilia, additional, Nicolini, Francesco, additional, Niccoli, Giampaolo, additional, and Ardissino, Diego, additional

Published
2023
Full Text
View/download PDF

17. Microvascular Complications Are Associated With Coronary Collateralization in Type 2 Diabetes and Chronic Occlusion

Author

Gurgoglione, Filippo Luca, primary, Pitocco, Dario, additional, Montone, Rocco A, additional, Rinaldi, Riccardo, additional, Bonadonna, Riccardo C, additional, Magnani, Giulia, additional, Calvieri, Camilla, additional, Solinas, Emilia, additional, Rizzi, Alessandro, additional, Tartaglione, Linda, additional, Flex, Andrea, additional, Viti, Luca, additional, Trani, Carlo, additional, Ardissino, Diego, additional, Crea, Filippo, additional, and Niccoli, Giampaolo, additional

Published
2023
Full Text
View/download PDF

19. Air pollution and out-of-hospital cardiac arrest risk

Author

Moderato, Luca, primary, Aschieri, Daniela, additional, Lazzeroni, Davide, additional, Rossi, Luca, additional, Bricoli, Serena, additional, Biagi, Andrea, additional, Ferraro, Stefano, additional, Binno, SImone, additional, Monello, Alberto, additional, Pellizzoni, Valentina, additional, Sticozzi, Concetta, additional, Zanni, Alessia, additional, Magnani, Giulia, additional, Gurgoglione, Filippo Luca, additional, CAPUCCI, ALESSANDRO, additional, Nani, Stefano, additional, Montone, Rocco A, additional, Ardissino, Diego, additional, Nicolini, Francesco, additional, and Niccoli, Giampaolo, additional

Published
2023
Full Text
View/download PDF

21. 702 PROGNOSTIC ROLE OF MYOCARDIAL VIABILITY ASSESSMENT BY 18F-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY IN STEMI PATIENTS WITH LATE PRESENTATION

Author

Denegri, Andrea, primary, Gurgoglione, Filippo Luca, additional, Magnani, Giulia, additional, Montagna, Riccardo, additional, Vignali, Luigi, additional, Paoli, Giorgia, additional, Graziani, Tiziano, additional, Ruffini, Livia, additional, Ardissino, Diego, additional, and Niccoli, Giampaolo, additional

Published
2022
Full Text
View/download PDF

23. Sex-Related Differences in Long-Term Outcomes After Early-Onset Myocardial Infarction

Author

Ardissino, Maddalena, primary, Nelson, Adam J., additional, Maglietta, Giuseppe, additional, Malagoli Tagliazucchi, Guidantonio, additional, Disisto, Caterina, additional, Celli, Patrizia, additional, Ferrario, Maurizio, additional, Canosi, Umberto, additional, Cernetti, Carlo, additional, Negri, Francesco, additional, Merlini, Piera Angelica, additional, Tubaro, Marco, additional, Berzuini, Carlo, additional, Manzalini, Chiara, additional, Ignone, Gianfranco, additional, Campana, Carlo, additional, Moschini, Luigi, additional, Ponte, Elisabetta, additional, Pozzi, Roberto, additional, Fetiveau, Raffaela, additional, Buratti, Silvia, additional, Paraboschi, Elvezia Maria, additional, Asselta, Rosanna, additional, Botti, Andrea, additional, Tuttolomondo, Domenico, additional, Barocelli, Federico, additional, Bricoli, Serena, additional, Biagi, Andrea, additional, Bonura, Rosario, additional, Moccetti, Tiziano, additional, Crocamo, Antonio, additional, Benatti, Giorgio, additional, Paoli, Giorgia, additional, Solinas, Emilia, additional, Notarangelo, Maria Francesca, additional, Moscarella, Elisabetta, additional, Calabrò, Paolo, additional, Duga, Stefano, additional, Magnani, Giulia, additional, and Ardissino, Diego, additional

Published
2022
Full Text
View/download PDF

25. Additional file 1 of Microvascular complications identify a specific coronary atherosclerotic phenotype in patients with type 2 diabetes mellitus

Author

Montone, Rocco A., Pitocco, Dario, Gurgoglione, Filippo Luca, Rinaldi, Riccardo, Del Buono, Marco Giuseppe, Camilli, Massimiliano, Rizzi, Alessandro, Tartaglione, Linda, Rizzo, Gaetano Emanuele, Di Leo, Mauro, Flex, Andrea, Russo, Michele, Liuzzo, Giovanna, Magnani, Giulia, Bonadonna, Riccardo C., Ardissino, Diego, Crea, Filippo, and Niccoli, Giampaolo

Abstract

Additional file 1: Table S1. Predictors of DMC in the overall population by univariate and multivariate logistic regression analysis. Table S2. Clinical, echocardiographic and angiographic features in the overall OCT population according to the presence or absence of DMC. Table S3. Sensitivity analysis of OCT characteristics of coronary plaques in the culprit vessel according to the presence or absence of diabetic microvascular complications excluding patients with diabetic neuropathy. Table S4. Predictors of large calcifications in the OCT sub-group by univariate and multivariate logistic regression analysis. Table S5. Predictors of healed plaque phenotype in the OCT sub-group by univariate and multivariate logistic regression analysis. Table S6. Predictors of lipid plaque phenotype in the OCT sub-group by univariate and multivariate logistic regression analysis. Table S7. Sensitivity analysis of clinical outcome according to the presence or absence of diabetic microvascular complications including only patients on therapy with metformin at the time of discharge. Table S8. Sensitivity analysis of predictors of MACEs including only patients on therapy with metformin at the time of discharge by univariate and multivariate Cox regression analysis. Table S9. Sensitivity analysis of clinical outcome according to the presence or absence of diabetic microvascular complications including only patients with ACS as clinical presentation. Table S10. Sensitivity analysis of predictors of MACEs in the ACS population by univariate and multivariate Cox regression analysis. Table S11. Sensitivity analysis of clinical outcome according to the presence or absence of diabetic microvascular complications including only patients with CCS as clinical presentation. Table S12. Sensitivity analysis of predictors of MACEs in the CCS population by univariate and multivariate Cox regression analysis. Figure S1. A Clinical outcomes in the overall population stratified according to the number of DMC. B Kaplan–Meier curve for MACEs according to the number of DMC. Abbreviations: MACEs; Major Adverse Cardiovascular Events; DMC: Diabetic Microvascular Complications.

Published
2022
Full Text
View/download PDF

27. 189 Long-term outcomes of early-onset myocardial infarction with non-obstructive coronary artery disease

Author

Magnani, Giulia, primary, Bricoli, Serena, additional, Ardissino, Maddalena, additional, Maglietta, Giuseppe, additional, Nelson, Adam, additional, Tagliazzuccchi, Guidoantonio Malagoli, additional, Disisto, Caterina, additional, Celli, Patrizia, additional, Ferrario, Maurizio, additional, Canosi, Umberto, additional, Cernetti, Carlo, additional, Negri, Francesco, additional, Merlini, Piera Angelica, additional, Tubaro, Marco, additional, Berzuini, Carlo, additional, Manzalini, Chiara, additional, Ignone, Giancarlo, additional, Campana, Carlo, additional, Moschini, Luigi, additional, Ponte, Elisabetta, additional, Pozzi, Roberto, additional, Fetiveau, Raffaella, additional, Buratti, Silvia, additional, Paraboschi, Elvezia, additional, Asselta, Rosanna, additional, Botti, Andrea, additional, Tuttolomondo, Domenico, additional, Barocelli, Federico, additional, Biagi, Andrea, additional, Bonura, Rosario, additional, Moccetti, Tiziano, additional, Crocamo, Antonio, additional, Benatti, Giorgio, additional, Paoli, Giorgia, additional, Solinas, Emilia, additional, Notarangelo, Maria Francesca, additional, Moscarella, Elisabetta, additional, Calabrò, Paolo, additional, Duga, Stefano, additional, Niccoli, Giampoalo, additional, and Ardissino, Diego, additional

Published
2021
Full Text
View/download PDF

28. 346 Baroreflex sensitivity and autonomic function in Takotsubo syndrome long after the acute phase

Author

Zinelli, Martina, primary, Lazzeroni, Davide, additional, Moderato, Luca, additional, Centorbi, Claudio Stefano, additional, Bini, Matteo, additional, Magnani, Giulia, additional, Brambilla, Lorenzo, additional, Castiglioni, Paolo, additional, Piepoli, Massimo, additional, Cabassi, Aderville, additional, Ardissino, Diego, additional, Coruzzi, Paolo, additional, and Niccoli, Giampaolo, additional

Published
2021
Full Text
View/download PDF

29. 345 Blood pressure and autonomic function in essential hypertension: comparative evaluation of 24-hour heart rate variability and blood pressure

Author

Pivetti, Vanessa, primary, Lazzeroni, Davide, additional, Moderato, Luca, additional, Centorbi, Claudio Stefano, additional, Bini, Matteo, additional, Brambilla, Lorenzo, additional, Magnani, Giulia, additional, Piepoli, Massimo, additional, Ardissino, Diego, additional, Niccoli, Giampaolo, additional, Coruzzi, Paolo, additional, and Cabassi, Aderville, additional

Published
2021
Full Text
View/download PDF

30. 347 From arterial hypertension to left ventricular hypertrophy and heart failure: role of cardiopulmonary exercise testing in heart failure with preserved ejection fraction

Author

Borsi, Leonardo, primary, Lazzeroni, Davide, additional, Moderato, Luca, additional, Centorbi, Claudio Stefano, additional, Bini, Matteo, additional, Magnani, Giulia, additional, Brambilla, Lorenzo, additional, Piepoli, Massimo, additional, Cabassi, Aderville, additional, Ardissino, Diego, additional, Coruzzi, Paolo, additional, and Niccoli, Giampaolo, additional

Published
2021
Full Text
View/download PDF

31. 338 Autonomic function and hyper-adrenergic tone despite beta-blockers in chronic coronary syndrome with preserved ejection fraction: prevalence and related factors

Author

Italia, Antonio, primary, Lazzeroni, Davide, additional, Moderato, Luca, additional, Centorbi, Claudio, additional, Bini, Matteo, additional, Magnani, Giulia, additional, Castiglioni, Paolo, additional, Brambilla, Lorenzo, additional, Piepoli, Massimo, additional, Coruzzi, Paolo, additional, Niccoli, Giampaolo, additional, and Ardissino, Diego, additional

Published
2021
Full Text
View/download PDF

32. Long‐Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS‐TIMI 54 Trial

Author

Bergmark, Brian A., primary, Bhatt, Deepak L., additional, Steg, P. Gabriel, additional, Budaj, Andrzej, additional, Storey, Robert F., additional, Gurmu, Yared, additional, Kuder, Julia F., additional, Im, KyungAh, additional, Magnani, Giulia, additional, Oude Ophuis, Ton, additional, Hamm, Christian, additional, Špinar, Jindřich, additional, Kiss, Robert G., additional, Van de Werf, Frans J., additional, Montalescot, Gilles, additional, Johanson, Per, additional, Braunwald, Eugene, additional, Sabatine, Marc S., additional, and Bonaca, Marc P., additional

Published
2021
Full Text
View/download PDF

33. Ticagrelor versus prasugrel in acute coronary syndrome: sex-specific analysis from the RENAMI Registry

Author

AL RAISI, Sara, primary, PROTTY, Majd, additional, RAPOSEIRAS-ROUBÍN, Sergio, additional, D’ASCENZO, Fabrizio, additional, ABU-ASSI, Emad, additional, ARIZA-SOLÉ, Albert, additional, MANZANO-FERNÁNDEZ, Sergio, additional, TEMPLIN, Christian, additional, VELICKI, Lazar, additional, XANTHOPOULOU, Ioanna, additional, CERRATO, Enrico, additional, QUADRI, Giorgio, additional, ROGNONI, Andrea, additional, BOCCUZZI, Giacomo, additional, MONTABONE, Andrea, additional, TAHA, Salma, additional, DURANTE, Alessandro, additional, GILI, Sebastiano, additional, MAGNANI, Giulia, additional, AUTELLI, Michele, additional, GROSSO, Alberto, additional, FLORES-BLANCO, Pedro, additional, VARBELLA, Ferdinando, additional, CESPÓN-FERNÁNDEZ, María, additional, GALLO, Diego, additional, MORBIDUCCI, Umberto, additional, DOMÍNGUEZ-RODRÍGUEZ, Alberto, additional, CEQUIER, Ángel, additional, GAITA, Fiorenzo, additional, ALEXOPOULOS, Dimitrios, additional, VALGIMIGLI, Marco, additional, ÍÑIGUEZ-ROMO, Andrés, additional, and KINNAIRD, Tim, additional

Published
2021
Full Text
View/download PDF

34. Sex-Related Differences in Long-Term Outcomes After Early-Onset Myocardial Infarction

Author

Maddalena Ardissino, Adam J. Nelson, Giuseppe Maglietta, Guidantonio Malagoli Tagliazucchi, Caterina Disisto, Patrizia Celli, Maurizio Ferrario, Umberto Canosi, Carlo Cernetti, Francesco Negri, Piera Angelica Merlini, Marco Tubaro, Carlo Berzuini, Chiara Manzalini, Gianfranco Ignone, Carlo Campana, Luigi Moschini, Elisabetta Ponte, Roberto Pozzi, Raffaela Fetiveau, Silvia Buratti, Elvezia Maria Paraboschi, Rosanna Asselta, Andrea Botti, Domenico Tuttolomondo, Federico Barocelli, Serena Bricoli, Andrea Biagi, Rosario Bonura, Tiziano Moccetti, Antonio Crocamo, Giorgio Benatti, Giorgia Paoli, Emilia Solinas, Maria Francesca Notarangelo, Elisabetta Moscarella, Paolo Calabrò, Stefano Duga, Giulia Magnani, Diego Ardissino, Ardissino, Maddalena, Nelson, Adam J, Maglietta, Giuseppe, Malagoli Tagliazucchi, Guidantonio, Disisto, Caterina, Celli, Patrizia, Ferrario, Maurizio, Canosi, Umberto, Cernetti, Carlo, Negri, Francesco, Merlini, Piera Angelica, Tubaro, Marco, Berzuini, Carlo, Manzalini, Chiara, Ignone, Gianfranco, Campana, Carlo, Moschini, Luigi, Ponte, Elisabetta, Pozzi, Roberto, Fetiveau, Raffaela, Buratti, Silvia, Paraboschi, Elvezia Maria, Asselta, Rosanna, Botti, Andrea, Tuttolomondo, Domenico, Barocelli, Federico, Bricoli, Serena, Biagi, Andrea, Bonura, Rosario, Moccetti, Tiziano, Crocamo, Antonio, Benatti, Giorgio, Paoli, Giorgia, Solinas, Emilia, Notarangelo, Maria Francesca, Moscarella, Elisabetta, Calabrò, Paolo, Duga, Stefano, Magnani, Giulia, and Ardissino, Diego

Subjects
myocardial infarction, baseline risk difference, young, long term outcome, gender, Cardiology and Cardiovascular Medicine
Abstract

ImportanceThere is growing awareness of sex-related differences in cardiovascular risk profiles, but less is known about whether these extend to pre-menopausal females experiencing an early-onset myocardial infarction (MI), who may benefit from the protective effects of estrogen exposure.MethodsA nationwide study involving 125 Italian Coronary Care Units recruited 2,000 patients between 1998 and 2002 hospitalized for a type I myocardial infarction before the age of 45 years (male, n = 1,778 (88.9%). Patients were followed up for a median of 19.9 years (IQR 18.1–22.6). The primary composite endpoint was the occurrence of cardiovascular death, non-fatal myocardial re-infarction or non-fatal stroke, and the secondary endpoint of hospitalization for revascularisation by means of a percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG).ResultsST-elevation MI was the most frequent presentation among both men and women (85.1 vs. 87.4%, p = ns), but the men had a greater baseline coronary atherosclerotic burden (median Duke Coronary Artery Disease Index: 48 vs. 23; median Syntax score 9 vs. 7; both p < 0.001). The primary composite endpoint occurred less frequently among women (25.7% vs. 37.0%; adjusted hazard ratio: 0.69, 95% CI 0.52–0.91; p = 0.01) despite being less likely to receive treatment with most secondary prevention medications during follow up.ConclusionsThere are significant sex-related differences in baseline risk factors and outcomes among patients with early-onset MI: women present with a lower atherosclerotic disease burden and, although they are less frequently prescribed secondary prevention measures, experience better long-term outcomes.Trial Registration4272/98 Ospedale Niguarda, Ca' Granda 03/09/1998.

Published
2022

35. Sudden cardiac death after early-onset myocardial infarction. A multicentre longitudinal cohort study with 20 years' follow-up.

Author

Bricoli S, Magnani G, Ardissino M, Maglietta G, Celli P, Ferrario M, Canosi U, Cernetti C, Negri F, Merlini PA, Tubaro M, Berzuini C, Manzalini C, Moschini L, Ponte E, Pozzi R, Buratti S, Botti A, Barocelli F, Biagi A, Bonura R, Bearzot L, Moccetti T, Crocamo A, Notarangelo MF, Moscarella E, Calabrò P, Niccoli G, and Ardissino D

Abstract

Background: Sudden cardiac death (SCD) is a serious consequence of a myocardial infarction (MI), but identifying patients at risk of developing SCD remains a major clinical challenge especially in the case of juvenile MI. The aim of this study was to identify predictors of SCD after early-onset MI using long-term follow-up data relating to a large nationwide patient cohort., Methods: The Italian Genetic Study on Early-onset MI enrolled 2,000 patients experiencing a first MI before the age of 45 years, who were followed up for a median of 19.9 years. Fine-Gray proportional hazard models were used to assess the associations between their clinical, demographic and index event data and the occurrence of SCD., Results: SCD occurred in 195 patients, who were more frequently males, hypertensive and/or diabetic; had a history of previous thromboembolic events with a greater atherosclerotic burden; and had a lower left ventricular ejection fraction (LVEF) after the index event. Multivariable analysis showed that the independent predictors of SCD were diabetes, hypertension, previous thromboembolic events, higher Syntax score, and a lower LVEF. There was no clear evidence of the clustering of SCD events during follow-up. SCD was the first post-MI clinical event in 101 patients; the remaining 94 experienced SCD after a non-fatal MI or hospitalisation for coronary revascularisation., Conclusions: SCD frequently occurs during the 20 years after early-onset MI. The nature of the identified predictors and the absence of clustering suggests that the pathophysiological basis of SCD may be related to progressive coronary atherosclerosis., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
Full Text
View/download PDF

36. Polymer-free stents for percutaneous coronary intervention in diabetic patients: a systematic review and meta-analysis.

Author

Gurgoglione FL, Donelli D, Antonelli M, Vignali L, Benatti G, Solinas E, Tadonio I, Magnani G, Denegri A, Lazzeroni D, Montone RA, Bonadonna RC, Nicolini F, Ardissino D, and Niccoli G

Abstract

Aim: To compare the efficacy of polymer-free drug-eluting stents (PF-DES) versus other stents in diabetic patients with coronary artery disease undergoing percutaneous coronary interventions. Materials & methods: A systematic review and meta-analysis were performed to identify pertinent randomized controlled trials. The primary end point was the occurrence of target lesion failure. Results: Eight randomized controlled trials were included for a total of 4854 subjects. The PF-DES group experienced a trend in favor of a lower rate of target lesion failure (Incidence rate ratio = 0.91; p  = 0.11) and a significantly lower rate of cardiac mortality, as compared with the control group (Incidence rate ratio = 0.82; p  = 0.04). However, statistical significance was lost if bare-metal stent patients were excluded and a trend in favor of the PF-DES strategy was reported only for cardiac mortality. Conclusion: PF-DES could be a valuable strategy in diabetic patients with coronary artery disease undergoing percutaneous coronary interventions.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results