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Your search keyword '"Magierowska, Katarzyna"' showing total 19 results
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19 results on '"Magierowska, Katarzyna"'

5. Physiological healing of chronic gastric ulcer is not impaired by the hydrogen sulphide (H2S)-releasing derivative of acetylsalicylic acid (ATB-340): functional and proteomic approaches.

Author

Korbut, Edyta, Suski, Maciej, Śliwowski, Zbigniew, Bakalarz, Dominik, Głowacka, Urszula, Wójcik-Grzybek, Dagmara, Ginter, Grzegorz, Krukowska, Kinga, Brzozowski, Tomasz, Magierowski, Marcin, Wallace, John L., and Magierowska, Katarzyna

Subjects
STOMACH ulcers, ASPIRIN, HYDROGEN sulfide, WOUND healing, HEALING, SUPPRESSORS of cytokine signaling
Abstract

Gastric ulcers affect approx. 10% of population. Non-steroidal anti-inflammatory drugs (NSAIDs), including acetylsalicylic acid (ASA) predispose to or impair the physiologically complex healing of pre-existing ulcers. Since H2S is an endogenous cytoprotective molecule, we hypothesized that new H2S-releasing ASA-derivative (ATB-340) could overcome pathological impact of NSAIDs on GI regeneration. Clinically translational gastric ulcers were induced in Wistar rats using state-of-the-art microsurgical model employing serosal application of acetic acid. This was followed by 9 days long i.g. daily treatment with vehicle, ATB-340 (6–24 mg/kg) or equimolar ASA doses (4–14 mg/kg). Ulcer area was assessed macro- and microscopically. Prostaglandin (PG)E2 levels, indicating pharmacological activity of NSAIDs and 8-hydroxyguanozine content, reflecting nucleic acids oxidation in serum/gastric mucosa, were determined by ELISA. Qualitative and/or quantitative pathway-specific alterations at the ulcer margin were evaluated using real-time PCR and mass spectrometry-based proteomics. ASA, unlike ATB-340, dose-dependently delayed/impaired gastric tissue recovery, deregulating 310 proteins at the ulcer margin, including Ras signalling, wound healing or apoptosis regulators. ATB-340 maintained NSAIDs-specific cyclooxygenase-inhibiting capacity on systemic and GI level but in time-dependent manner. High dose of ATB-340 (24 mg/kg daily), but not ASA, decreased nucleic acids oxidation and upregulated anti-oxidative/anti-inflammatory heme oxygenase-1, 24-dehydrocholesterol reductase or suppressor of cytokine signalling (SOCS3) at the ulcer margin. Thus, ASA impairs the physiological healing of pre-existing gastric ulcers, inducing the extensive molecularly functional and proteomic alterations at the wound margin. H2S-releasing ATB-340 maintains the target activity of NSAIDs with limited impact on gastric PGE2 signalling and physiological GI regeneration, enhancing anti-inflammatory and anti-oxidative response, and providing the pharmacological advantage. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Hydrogen Sulfide-Releasing Indomethacin-Derivative (ATB-344) Prevents the Development of Oxidative Gastric Mucosal Injuries

Author

Głowacka, Urszula, primary, Magierowski, Marcin, additional, Śliwowski, Zbigniew, additional, Cieszkowski, Jakub, additional, Szetela, Małgorzata, additional, Wójcik-Grzybek, Dagmara, additional, Chmura, Anna, additional, Brzozowski, Tomasz, additional, Wallace, John L., additional, and Magierowska, Katarzyna, additional

Published
2023
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9. Tu1534: INTESTINAL ALKALINE PHOSPHATASE THERAPY COUNTERACTS THE INTENSIFICATION OF COLITIS IN OBESE MICE SUBJECTED TO FORCED TREADMILL EXERCISE BY SHAPING THE INTESTINAL MICROBIOTA AND ATTENUATING OF PRO-INFLAMMATORY AND OXIDATIVE STRESS BIOMARKERS

Author

Wójcik-Grzybek, Dagmara, primary, Surmiak, Marcin, additional, Kwiecien, Slawomir, additional, Sliwowski, Zbigniew, additional, Magierowski, Marcin, additional, Bilski, Jan, additional, Mazur-Bialy, Agnieszka I., additional, Targosz, Aneta, additional, Magierowska, Katarzyna, additional, Ptak-Belowska, Agata, additional, and Brzozowski, Tomasz, additional

Published
2022
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10. Sa1129: THERAPEUTIC EFFECT OF MITOCHONDRIA-TARGETING HYDROGEN SULFIDE PRODRUG, AP39 IN THE HEALING OF CHRONIC GASTRIC ULCERS

Author

Wójcik-Grzybek, Dagmara, primary, Sliwowski, Zbigniew, additional, Ginter, Grzegorz, additional, Magierowska, Katarzyna, additional, Danielak, Aleksandra, additional, Kwiecien, Slawomir, additional, Cieszkowski, Jakub, additional, Futyma, Tomasz, additional, Chmura, Anna, additional, Whiteman, Matthew, additional, and Magierowski, Marcin, additional

Published
2022
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11. Mo1618: EXPRESSION OF TIGHT JUNCTION PROTEINS IS MODULATED BY MATERNAL OBESITY INDUCED BY DIFFERENT DIET PROGRAM. EVIDENCE FROM INTESTINE OF PREGNANT DAMS AND THEIR MALE AND FEMALE RAT OFFSPRING

Author

Glowacka, Urszula, primary, Gawlinska, Kinga, additional, Magierowski, Marcin, additional, Sliwowski, Zbigniew, additional, Bakalarz, Dominik, additional, Magierowska, Katarzyna, additional, Korbut, Edyta, additional, and Brzozowski, Tomasz, additional

Published
2022
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12. Tu1167b: INTRODUCTION TO THE THERAPEUTIC POTENTIAL OF CARBON MONOXIDE (CO) RELEASED FROM PHARMACOLOGICAL DONORS AGAINST BARRETT'S METAPLASIA AND ESOPHAGEAL ADENOCARCINOMA (EAC) DEVELOPMENT

Author

Krukowska, Kinga, primary, Danielak, Aleksandra, additional, Wierdak, Mateusz, additional, Wójcik-Grzybek, Dagmara, additional, Bakalarz, Dominik, additional, Magierowska, Katarzyna, additional, Glowacka, Urszula, additional, Cieszkowski, Jakub, additional, Ginter, Grzegorz, additional, Szetela, Malgorzata, additional, Brzozowski, Tomasz, additional, Korbut, Edyta, additional, and Magierowski, Marcin, additional

Published
2022
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13. Role of Obesity, Physical Exercise, Adipose Tissue-Skeletal Muscle Crosstalk and Molecular Advances in Barrett’s Esophagus and Esophageal Adenocarcinoma

Author

Bilski, Jan, primary, Pinkas, Monika, additional, Wojcik-Grzybek, Dagmara, additional, Magierowski, Marcin, additional, Korbut, Edyta, additional, Mazur-Bialy, Agnieszka, additional, Krzysiek-Maczka, Gracjana, additional, Kwiecien, Slawomir, additional, Magierowska, Katarzyna, additional, and Brzozowski, Tomasz, additional

Published
2022
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14. Sa1208 THE GUT-SPARING EFFECTS OF ROFECOXIB, A CYCLOOXYGENASE-2 INHIBITOR, AND RESVERATROL, A PREFERENTIAL CYCLOOXYGENASE-1 INHIBITOR IN EXPERIMENTAL COLITIS, ARE ELIMINATED BY THE SIMULTANEOUS BLOCKADE OF NITRIC OXIDE SYNTHASE

Author

Kwiecien, Slawomir, Sliwowski, Zbigniew, Wójcik-Grzybek, Dagmara, Magierowska, Katarzyna, Chmura, Anna, Targosz, Aneta, Glowacka, Urszula, Strzalka, Malgorzata, Ptak-Belowska, Agata, Magierowski, Marcin, and Brzozowski, Tomasz

Published
2024
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16. Microbiome Profile and Molecular Pathways Alterations in Gastrointestinal Tract by Hydrogen Sulfide-Releasing Nonsteroidal Anti-Inflammatory Drug (ATB-352): Insight into Possible Safer Polypharmacy

Author

Głowacka, Urszula, primary, Magierowska, Katarzyna, additional, Wójcik, Dagmara, additional, Hankus, Jerzy, additional, Szetela, Małgorzata, additional, Cieszkowski, Jakub, additional, Korbut, Edyta, additional, Danielak, Aleksandra, additional, Surmiak, Marcin, additional, Chmura, Anna, additional, Wallace, John L., additional, and Magierowski, Marcin, additional

Published
2022
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17. Hydrogen sulfide as a modulator of mitochondrial activity in the protection against oxidative NSAIDs-induced gastric injury

Author

Danielak, Aleksandra, primary, Wójcik, Dagmara, additional, Magierowska, Katarzyna, additional, Korbut, Edyta, additional, Bakalarz, Dominik, additional, Głowacka, Urszula, additional, Futyma, Tomasz, additional, Szetela, Małgorzata, additional, Brzozowski, Tomasz, additional, Wallace, John, additional, Whiteman, Matthew, additional, and Magierowski, Marcin, additional

Published
2022
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