1,336 results on '"Macedo, F."'
Search Results
2. Reverse left ventricular remodeling after aortic valve replacement for aortic stenosis: a systematic review and meta-analysis.
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Sousa Nunes, F., Amaral Marques, C., Isabel Pinho, A., Sousa-Pinto, B., Beco, A., Ricardo Silva, J., Saraiva, F., Macedo, F., Leite-Moreira, A., and Sousa, C.
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- 2024
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3. Reverse left ventricular remodeling after aortic valve replacement for aortic stenosis: a systematic review and meta-analysis.
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Nunes, F. Sousa, Marques, C. Amaral, Pinho, A. Isabel, Sousa-Pinto, B., Beco, A., Silva, J. Ricardo, Saraiva, F., Macedo, F., Leite-Moreira, A., and Sousa, C.
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- 2024
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4. No difference in patient-reported outcomes or range of motion between ultracongruent and posterior stabilized total knee arthroplasty: A randomized controlled trial.
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Macedo F, Lucas J, Cunha P, Rocha M, Cerqueira R, Basto T, and Moura J
- Abstract
Purpose: Ultracongruent (UC) inserts were designed to overcome potential issues with posterior stabilized (PS) inserts, including bone resection, post-breakage, and patellar clunk syndrome. However, there remains a shortage of high-quality studies directly comparing this insert design to the established PS Total Knee Arthroplasty (TKA). This prospective randomized controlled trial (RCT) aimed to compare clinical outcomes, range of motion, and complications of UC and PS TKA., Methods: Ninety six patients with primary knee osteoarthritis were randomly assigned to either the PS or the UC group. There were no significant differences between the groups regarding age, body mass index, sex, or Osteoarthritis grade. The measured outcomes were Knee Injury and Osteoarthritis Outcome Score (KOOS) and Range of Motion (ROM), recorded preoperatively and at 3 and 6 months postoperative. Both the patient and interviewer were blinded to the allocation group., Results: Eighty one patients were included in the analysis, with a mean follow-up of 1.3 years. Both groups exhibited a gradual improvement in KOOS. Still, no statistically significant differences were observed between the groups during the follow-up examinations at 3 or 6 months in KOOS or range of motion. No complication occurred in either group during the follow-up period., Conclusion: Both designs demonstrated comparable positive outcomes, reinforcing the viability of UC designs as an alternative to the well-established PS TKA., Levels of Evidence: Level l, randomized controlled trial., Competing Interests: The authors declare no conflict of interest., (© 2024 The Author(s). Journal of Experimental Orthopaedics published by John Wiley & Sons Ltd on behalf of European Society of Sports Traumatology, Knee Surgery and Arthroscopy.)
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- 2024
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5. Corrigendum: Reverse left ventricular remodeling after aortic valve replacement for aortic stenosis: a systematic review and meta-analysis.
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Sousa Nunes F, Amaral Marques C, Isabel Pinho A, Sousa-Pinto B, Beco A, Ricardo Silva J, Saraiva F, Macedo F, Leite-Moreira A, and Sousa C
- Abstract
[This corrects the article DOI: 10.3389/fcvm.2024.1407566.]., (© 2024 Sousa Nunes, Amaral Marques, Isabel Pinho, Sousa-Pinto, Beco, Ricardo Silva, Saraiva, Macedo, Leite-Moreira and Sousa.)
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- 2024
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6. Incidence of coronary anomalies in patients with D-transposition of great arteries (D-TGA) after arterial switch operation (ASO)
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Calvao, J, primary, Costa, C, additional, Amador, A F, additional, Proenca, T, additional, Cabrita, A, additional, Marques, C, additional, Pinho, A, additional, Oliveira, C, additional, Santos, L, additional, Carvalho, A, additional, Rebelo, J, additional, Vasconcelos, M, additional, Moreira, J, additional, Cruz, C, additional, and Macedo, F, additional
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- 2023
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7. Left bundle branch block cardiomyopathy: an intriguing and defiant entity from diagnosis to treatment
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Marques, C, primary, Cabrita, C, additional, Carvalho, M M, additional, Calvao, J, additional, Amador, A F, additional, Costa, C M, additional, Pinho, A I, additional, Santos, L D, additional, Oliveira, C, additional, Moreira, H S, additional, Rocha, M, additional, Palma, P M, additional, Martins, E, additional, and Macedo, F, additional
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- 2023
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8. Head-up tilt test induced asystole and recurrent syncope: a follow-up study
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Amador, A, primary, Calvao, C, additional, Costa, C, additional, Cabrita, A, additional, Marques, C, additional, Pinho, A, additional, Oliveira, C, additional, Santos, L, additional, Moreira, H, additional, Palma, P, additional, Rocha, M, additional, Amorim, S, additional, Freitas, J, additional, and Macedo, F, additional
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- 2023
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9. Study of the centers responsible for the TL emission by EPR and PL analysis of Eu-doped CaSiO3 phosphors synthesized by the devitrification method
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Gonzales-Lorenzo, Carlos D., primary, Rao, T.K. Gundu, additional, Ccollque-Quispe, Alberto A., additional, Ayala-Arenas, Jorge, additional, Gomes, Monise B., additional, Silva-Carrera, Betzabel N., additional, Gennari, Roseli F., additional, Pachas, Valeria S., additional, Monzon-Macedo, F., additional, Loro, H., additional, Chubaci, Jose F.D., additional, Cano, Nilo F., additional, Rocca, René R., additional, and Watanabe, Shigueo, additional
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- 2023
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10. Non-Hodgkin's Anaplastic Large T-Cell Lymphoma: A Case Report.
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Halpern GA, Miziara Brochi L, Gomes C, Lachter Zusman G, Carvalho de Macedo F, and Annete Damasceno Rodrigues J
- Abstract
Anaplastic large T/null cell lymphoma (ALCL) is an aggressive non-Hodgkin's lymphoma (NHL) that most commonly affects young men. Herein, we present a case of a 32-year-old male patient in severe condition with ulcerated right axillary adenopathy, diffuse subcutaneous nodules, and sepsis. He was admitted to the ED, where a bone marrow aspirate and biopsy confirmed the diagnosis of ALCL. The immunohistochemical examination demonstrated neoplastic cells with immunopositivity with antibodies CD3 (focal), CD30 (diffuse), protein ALK-1 (diffuse), and epithelial membrane antigen (EMA) (multifocal). Appropriate chemotherapy treatment was done, and the patient showed a complete response. This article aims to report a rare subtype of NHL to increase awareness and bring up a discussion about the clinical presentation and diagnostic features of ALCL. Moreover, we discuss treatment regimens that are currently used and have shown reasonable disease remission rates., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Halpern et al.)
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- 2024
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11. Foxo3 regulates cortical and medullary thymic epithelial cell homeostasis with implications in T cell development.
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Ribeiro C, Ferreirinha P, Landry JJM, Macedo F, Sousa LG, Pinto R, Benes V, and Alves NL
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- Animals, Mice, Mice, Knockout, Cell Differentiation, T-Lymphocytes metabolism, T-Lymphocytes immunology, Mice, Inbred C57BL, Thymus Gland metabolism, Thymus Gland cytology, Forkhead Box Protein O3 metabolism, Forkhead Box Protein O3 genetics, Epithelial Cells metabolism, Homeostasis
- Abstract
Within the thymus, thymic epithelial cells (TECs) create dedicated microenvironments for T cell development and selection. Considering that TECs are sensitive to distinct pathophysiological conditions, uncovering the molecular elements that coordinate their thymopoietic role has important fundamental and clinical implications. Particularly, medullary thymic epithelial cells (mTECs) play a crucial role in central tolerance. Our previous studies, along with others, suggest that mTECs depend on molecular factors linked to genome-protecting pathways, but the precise mechanisms underlying their function remain unknown. These observations led us to examine the role of Foxo3, as it is expressed in TECs and involved in DNA damage response. Our findings show that mice with TEC-specific deletion of Foxo3 (Foxo3
cKO ) displayed a disrupted mTEC compartment, with a more profound impact on the numbers of CCL21+ and thymic tuft mTEClo subsets. At the molecular level, Foxo3 controls distinct functional modules in the transcriptome of cTECs and mTECs under normal conditions, which includes the regulation of ribosomal biogenesis and DNA damage response, respectively. These changes in the TEC compartment resulted in a reduced total thymocyte cellularity and specific changes in regulatory T cell and iNKT cell development in the Foxo3cKO thymus. Lastly, the thymic defects observed in adulthood correlated with mild signs of altered peripheral immunotolerance in aged Foxo3cKO mice. Moreover, the deficiency in Foxo3 moderately aggravated the autoimmune predisposition observed in Aire-deficient mice. Our findings highlight the importance of Foxo3 in preserving the homeostasis of TECs and in supporting their role in T cell development and tolerance., (© 2024. The Author(s).)- Published
- 2024
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12. Stabbed in the right place: The millimetric line between luck and disaster.
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Amaral Marques C, Mil-Homens F, Resende CX, Fernandes J, Gouveia D, Pinho P, and Macedo F
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- Humans, Male, Wounds, Stab
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- 2024
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13. Pulmonary valve replacement in tetralogy of Fallot - who and how?
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Costa CM, Cruz C, Pinho T, Torres S, Silva JC, Madureira JA, Salgueiro E, Casanova J, Pinho P, and Macedo F
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- Adult, Humans, Male, Treatment Outcome, Retrospective Studies, Pulmonary Valve surgery, Pulmonary Valve Insufficiency etiology, Pulmonary Valve Insufficiency surgery, Tetralogy of Fallot complications, Tetralogy of Fallot surgery, Heart Valve Prosthesis Implantation adverse effects, Cardiac Surgical Procedures adverse effects
- Abstract
Background and Aim: Pulmonary regurgitation is the most common complication in repaired tetralogy of Fallot patients. Severe chronic pulmonary regurgitation can be tolerated for decades, but if not treated, it can progress to symptomatic, irreversible right ventricular dilatation and dysfunction. We investigated clinical associations with pulmonary valve replacement among patients with significative pulmonary regurgitation and how interventional developments can change their management., Methods: All adult patients with repaired tetralogy of Fallot who were followed at an adult CHD Clinic at a single centre from 1980 to 2022 were included on their first outpatient visit. Follow-up was estimated from the time of correction surgery until one of the following events occurred first: pulmonary valve replacement, death, loss to follow-up or conclusion of the study., Results: We included 221 patients (116 males) with a median age of 19 (18-25). At a median age of 33 (10) years old, 114 (51%) patients presented significant pulmonary regurgitation. Among patients with significant pulmonary regurgitation, pulmonary valve replacement was associated with male gender, older age at surgical repair, and longer QRS duration in adulthood. Pulmonary valve replacement was performed in 50 patients, including four transcatheter pulmonary valve implantations, at a median age of 34 (14) years., Conclusion: Pulmonary regurgitation affects a large percentage of tetralogy of Fallot adult patients, requiring a long-term clinical and imaging follow-up. Sex, age at surgical repair and longer QRS are associated with the need of PVR among patients with significative pulmonary regurgitation. Clinical practice and current literature support TPVI as the future gold standard intervention.
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- 2024
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14. Diagnosis and Treatment of Low Back Pain: Synopsis of the 2021 US Department of Veterans Affairs and US Department of Defense Clinical Practice Guideline.
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Macedo F, Annaswamy T, Coller R, Buelt A, Glotfelter MA, Heideman PW, Kang D, Konitzer L, Okamoto C, Olson J, Pangarkar S, Sall J, Spacek LC, Steil E, Vogsland R, and Sandbrink F
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- Humans, United States, Low Back Pain therapy, Low Back Pain diagnosis, United States Department of Defense, United States Department of Veterans Affairs
- Abstract
Abstract: Low back pain is a significant issue in the US Department of Veterans Affairs and Department of Defense populations as well as the general US population at large. This type of pain can be distressing to those who experience its effects, leading patients to seek relief of their symptoms. In 2022, leadership within the US Department of Veterans Affairs and US Department of Defense approved a joint clinical practice guideline for the management of low back pain. The guideline provides evidence-based recommendations for assessing and managing low back pain. Development of the guideline included a systematic evidence review, which was guided by 12 key questions. A multidisciplinary team, which included clinical stakeholders, reviewed the evidence that was retrieved and developed 39 recommendations using the Grading of Recommendations Assessment, Development, and Evaluation system. The scope of the clinical practice guideline is broad; however, the authors have focused on key recommendations that are important for clinicians in the evaluation and nonoperative treatment of low back pain, including pharmacologic therapies and both noninvasive and invasive nonpharmacologic treatments., Competing Interests: Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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15. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19
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Einstein, A, Hirschfeld, C, Williams, M, Vitola, J, Better, N, Villines, T, Cerci, R, Shaw, L, Choi, A, Dorbala, S, Karthikeyan, G, Lu, B, Sinitsyn, V, Ansheles, A, Kudo, T, Bucciarelli-Ducci, C, Norgaard, B, Maurovich-Horvat, P, Campisi, R, Milan, E, Louw, L, Allam, A, Bhatia, M, Sewanan, L, Malkovskiy, E, Cohen, Y, Randazzo, M, Narula, J, Morozova, O, Pascual, T, Pynda, Y, Dondi, M, Paez, D, Hinterleitner, G, Lu, Y, Xu, Z, Erinne, I, Shetty, M, Lopez-Mattei, J, Parwani, P, Goda, A, Shirka, E, Bouyoucef, S, Chelghoum, L, Mansouri, F, Medjahedi, A, Naili, Q, Ridouh, M, Alasia, D, Alberghina, L, Aramayo, N, Buchara, D, Busso, F, Bustos Rivadero, J, Camilletti, J, Campanelli, H, Castro, R, Daicz, M, del Riego, H, Dragonetti, L, Echazarreta, D, Erriest, J, Faccio, F, Facello, A, Gallegos, H, Geronazzo, R, Glait, H, Hasbani, V, Jager, V, Lewkowicz, J, Lotti, J, Maciel, N, Masoli, O, Mastrovito, E, Medus, M, Merani, M, Molteni, S, Montecinos, M, Parisi, G, Sueldo, C, Perez de Arenaza, D, Quintana, L, Radzinschi, A, Redruello, M, Rodriguez, M, Rojas, H, Acuna, A, Schere, D, Traverso, S, Vazquez, G, Zeffiro, S, Sakanyan, M, Beuzeville, S, Boktor, R, Crowley, M, Downie, D, Dwivedi, G, Elison, B, Farouque, O, Jasper, K, Joshi, S, Lee, J, Lee, K, Lui, E, Mcconachie, P, Meaker, J, Nandurkar, D, Neill, J, O'Rourke, E, O'Sullivan, P, Pandos, G, Premaratne, M, Prior, D, Rutherford, N, Saunders, C, Taubman, K, Tauro, A, Taylor, A, Theuerle, J, Thomas, P, Tow, J, Upton, A, Vamadevan, S, Wayne, V, Wegner, E, Wong, D, Younger, J, Beitzke, D, Feuchtner, G, Sommer, O, Weiss, K, Maroz-Vadalazhskaya, N, Tserakhau, U, Homans, F, Van De Heyning, C, Araujo, R, Soldat-Stankovic, V, Stankovic, S, Almeida, A, Anselmi, C, Azevedo, G, Bittencourt, M, Pianta, D, Cabeda, E, Carreira, L, Coelho, I, de Amorim Fernandes, F, de Lorenzo, A, Delgado, R, Erthal, F, Fernandes, F, Fernandes, J, Ferreira de Souza, T, Foppa, M, Matos Alves, W, Gontijo, C, Gottlieb, I, Grossman, G, Albernaz Siqueira, M, Nomura, C, Koga, K, Lima, R, Lopes, R, Marcal Filho, H, Masiero, P, Mastrocola, L, Menezes de Siqueira, M, Mesquita, C, Naves, D, Penna, F, Pinto, I, Rocha, T, Rocha, J, Rodrigues, A, Salioni, L, Sanches, A, Santos, M, Da Silva, L, Schvartzman, P, Matushita, C, Senra, T, Silva, M, Soares, C, Spiro, B, Suaide Silva, C, Torres, R, Monte, G, Vilela, A, Villa, A, Voss, T, Waltrick, R, Zapparoli, M, Naseer, H, Garcheva-Tsacheva, M, Ouattara, T, Thou, S, Varoeun, S, Abikhzer, G, Beanlands, R, Chetrit, M, Dabreo, D, Dennie, C, Friedrich, M, Hafez, M, Hanneman, K, Miller, R, Oikonomou, A, Roifman, I, Small, G, Tandon, V, Trivedi, A, White, J, Zukotynski, K, Alay, R, Concha, C, Massardo, T, Abad, P, Anzola, K, Arturo, H, Benitez, L, Cadena, A, Zamudio, C, Calderon, A, Gutierrez Villamil, C, Jaimes, C, Londono, J, Lopez, N, Merlano-Gaitan, S, Murgieitio-Cabrera, R, Valencia, M, Vergel, D, Santamaria, A, Solis, F, Batinic, T, Franceschi, M, Paar, M, Prpic, M, Felipe Batista, C, Cabrera, L, Peix, A, Pena, Y, Rochela Vazquez, L, Ntalas, I, Kaminek, M, Kincl, V, Lang, O, Abdulla, J, Bottcher, M, Busk, M, Geisler, U, Gormsen, L, Hansson, N, Hess, S, Hove, J, Jensen, L, Jensen, M, Kragholm, K, Ovrehus, K, Rasmussen, J, Ronnow Sand, N, Sondergaard, H, Zaremba, T, Speckter, H, Amores, N, Velez, M, Alrahman, T, Elsamad, S, Abdelfattah, A, Elkaffas, S, Hassan, M, Hussein, E, Ibrahim, A, Kandeel, A, Ali, M, Shaaban, M, Flores, C, Gomez Leiva, V, Liiver, A, Larikka, M, Uusitalo, V, Agostini, D, Berger, C, Dietz, M, Hyafil, F, Ohana, M, Prigent, K, Regaieg, H, Sarda-Mantel, L, H-Ici, D, Ayetey, H, Angelidis, G, Fragkaki, C, Fragkiadaki, C, Georgoulias, P, Koutelou, M, Kyrozi, E, Lama, N, Prassopoulos, V, Spartalis, M, Zaglavara, T, Gonzalez, C, Gutierrez, G, Maldonado, A, Martinez, Y, Kovacs, A, Szilveszter, B, Banthia, N, Bhat, V, Choudhury, P, Chowdekar, V, Christopher, J, Garg, T, Goyal, N, Gupta, R, Gupta, A, Hephzibah, J, Jain, S, Krupa, J, Kumar, P, Kumar, S, Lalchandani, A, Mishra, A, Mishra, V, Mohan, P, Ozair, A, Pandey, S, Parameswaran, R, Patel, C, Patel, T, Patel, S, Vimala, L, Kumar Sarangi, D, Sengupta, S, Sethi, A, Sharma, A, Sharma, P, Shrigiriwar, A, Singh, S, Singh, H, Sood, A, Verma, A, Vyas, A, Soeriadi, E, Bun, E, Hutomo, F, Syawaluddin, H, Yudistiro, R, Albadr, A, Assadi, M, Emami, F, Emami-Ardekani, A, Farzanehfar, S, Jafari, R, Manafi-Farid, R, Tajik, M, Arnson, Y, Fuchs, S, Goldkorn, R, Kennedy, J, Leitman, M, Shalev, A, Acampa, W, Albano, D, Alongi, P, Arnone, G, Assante, R, Baritussio, A, Bauckneht, M, Bianco, F, Bonfiglioli, R, Bovenzi, F, Bruno, I, Bruno, A, Busnardo, E, Califaretti, E, Casoni, R, Censullo, V, Chierichetti, F, Chiocchi, M, Cittanti, C, Clemente, A, Cuocolo, A, De Rimini, M, De Vincentis, G, Della Tommasina, V, Dellegrottaglie, S, Erba, P, Evangelista, L, Faggi, L, Faragasso, E, Florimonte, L, Frantellizzi, V, Gatti, M, Gaudiano, A, Gelardi, F, Gerali, A, Gimelli, A, Guglielmo, M, Leccisotti, L, Liga, R, Liguori, C, Longo, G, Maffione, M, Marcassa, C, Matassa, G, Mele, D, Mircoli, L, Paccagnella, A, Pacella, S, Padovano, F, Pellegrini, D, Pergola, V, Pugliese, L, Quartuccio, N, Rampin, L, Ricci, F, Rubini, G, Russo, V, Sambuceti, G, Scatteia, A, Sciagra, R, Spidalieri, G, Stefanelli, A, Tedeschi, C, Ventroni, G, Baugh, D, Madu, E, Aikawa, T, Asano, H, Fujimoto, S, Fujise, K, Fukushima, Y, Fukuyama, K, Ichikawa, Y, Ideguchi, R, Iguchi, N, Imai, M, Ishimura, H, Isobe, S, Ito, K, Izawa, Y, Kadokami, T, Kasai, T, Kato, T, Kawamoto, T, Kiryu, S, Kumita, S, Manabe, O, Maruno, H, Matsumoto, N, Miyagawa, M, Moroi, M, Nagamachi, S, Nakajima, K, Nakazato, R, Nanasato, M, Naya, M, Norikane, T, Ohta, Y, Otomi, Y, Otsuka, H, Oyama-Manabe, N, Saito, M, Sarai, M, Sato, J, Sato, D, Shiraishi, S, Takanami, K, Takehana, K, Taniguchi, Y, Teragawa, H, Tomizawa, N, Umeji, K, Wakabayashi, Y, Yamada, S, Yamazaki, S, Yoneyama, T, Rawashdeh, M, Dautov, T, Makhdomi, K, Abass, M, Garashi, M, Siraj, Q, Kalnina, M, Haidar, M, Komiagiene, R, Kviecinskiene, G, Vajauskas, D, Karim, N, Doucoure, M, Reichmuth, L, Samuel, A, Dieng, M, Naojee, A, Hernandez, E, Alducin Tellez, C, Alexanderson-Rosas, E, Barragan, E, Cabada, M, Calderon, D, Carvajal-Juarez, I, Esparza, J, Gama-Moreno, M, Quinto, V, Gonzalez, N, Herrera-Zarza, M, Meave, A, Medina Verdugo, J, Melendez, G, Morales Murguia, R, Navarro Quiroz, C, Ornelas, M, Preciado-Anaya, A, Preciado-Gutierrez, O, Puente, A, Salazar, A, Rosales Uvera, S, Rosales-Uvera, S, Serna Macias, J, Sierra-Galan, L, Tirado Alderete, J, Vallejo, E, Faraggi, M, Sereegotov, E, Ben Rais, N, Alaoui, N, Kyiphyu, T, Oo, S, Win, S, Zar, H, Ghimire, R, Neupane, M, Glaudemans, A, Slart, R, Verschure, D, Allen, B, Edmond, J, Mckenzie, C, Tie, S, Van Pelt, N, Worthington, K, Young, C, Soli, I, Kana, S, Onubogu, U, Sani, M, Braten, A, Jorgensen, A, Vassbotn, H, Al Dhuhli, H, Jawa, Z, Tag, N, Fatima, S, Imran, M, Younis, M, Saadullah, M, Malo, Y, Lenturut-Katal, D, Castillo, M, Ortellado, J, Akhter, A, Cader, F, Hussain, R, Khan, S, Mandal, T, Nasreen, F, An, Y, Cao, D, Gong, L, Hou, Y, Jia, C, Li, T, Li, C, Liu, H, Liu, W, Liu, J, Ng, M, Shi, H, Tang, C, Wang, X, Wang, Z, Wang, Y, Wu, J, Yi, Y, Yuan, L, Zhang, T, Zhang, L, Chavez, E, Cruz, C, Llontop, C, Morales, R, Abrihan, P, Bustos-Barroso, A, Duldulao-Ogbac, M, Eduarte, C, Obaldo, J, Quinon, A, San Juan, B, San Juan, C, Sauler-Gomez, M, Uy, M, Kostkiewicz, M, Kunikowska, J, Teresinska, A, Urbanik, T, Bettencourt, N, Fontes-Carvalho, R, Gavina, C, Goncalves, L, Macedo, F, Moreno, N, Sousa, C, Timoteo, A, Vidigal, M, Al Heidous, M, Ramanathan, S, Arnous, S, Aytani, S, Byrne, A, Gleeson, T, Kerins, D, O'Brien, J, Bang, J, Bom, H, Cheon, M, Cheon, G, Cho, S, Hong, C, Jeong, Y, Kang, W, Kang, Y, Kim, J, Oh, S, So, Y, Song, H, Won, K, Yoo, S, Mitevska, I, Vavlukis, M, Salobir, B, Stalc, M, Benedek, T, Pop, M, Stan, C, Dariy, O, Gagarina, N, Itskovich, I, Karalkin, A, Kokov, A, Marina, G, Migunova, E, Pospelov, V, Ryzhkova, D, Sayfullina, G, Sergienko, V, Shurupova, I, Vakhromeeva, M, Valiullina, N, Zavadovsky, K, Zhuravlev, K, Abazid, R, Al Garni, T, Alasnag, M, Aljizeeri, A, Amer, H, Amro, A, Hamdy, H, Smettei, O, Saranovic, D, Vlajkovic, M, Keng, F, See, J, Berecova, Z, Mistinova, J, Evbuomwan, O, Govender, N, Hack, J, Hadebe, B, Hlongwa, K, Kaplan, M, Lakhi, H, Milos, K, Modiselle, M, More, S, Muambadzi, N, Scholtz, L, Barreiro-Perez, M, Blanco, I, Broncano, J, Camarero, A, Casans-Tormo, I, De Haro, J, Flotats, A, Garcia, E, Mendiguchia, C, Jimenez-Heffernan, A, Leta, R, Diaz, J, Vega, L, Manovel-Sanchez, A, Monzonis, A, Patrut, B, Pubul, V, Perez, R, Zeidan, N, Nanayakkara, D, Suliman, A, Engblom, H, Murtadha, M, Ostenfeld, E, Simonsson, M, Alkadhi, H, Buechel, R, Burger, P, Grani, C, Kamani, C, Kawel-Bohm, N, Klaeser, B, Manka, R, Prior, J, Kaewchur, T, Khiewvan, B, Kositwattanarerk, A, Namwongprom, S, Thientunyakit, T, Sayman, H, Yuksel, M, Sebikali, M, Okello, E, Korol, P, Noverko, I, Satyr, M, 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K. A., Doucoure M., Reichmuth L., Samuel A., Dieng M. L., Naojee A. S., Hernandez E. A., Alducin Tellez C. R., Alexanderson-Rosas E., Barragan E., Cabada M., Calderon D., Carvajal-Juarez I., Esparza J., Gama-Moreno M. G., Quinto V. G., Gonzalez N. C., Herrera-Zarza M. C., Meave A., Medina Verdugo J. G., Melendez G., Morales Murguia R. H., Navarro Quiroz C. S., Ornelas M., Preciado-Anaya A., Preciado-Gutierrez O. U., Puente A., Salazar A. R., Rosales Uvera S. G., Rosales-Uvera S., Serna Macias J. A., Sierra-Galan L., Sierra-Galan L. M., Tirado Alderete J. C., Vallejo E., Faraggi M., Sereegotov E., Ben Rais N., Alaoui N. I., Kyiphyu T., Oo S. T., Win S. M., Zar H., Ghimire R., Neupane M., Glaudemans A., Slart R., Verschure D., Allen B., Edmond J., Mckenzie C., Tie S., Van Pelt N., Worthington K., Young C., Soli I. A., Kana S., Onubogu U., Sani M., Braten A. T., Jorgensen A., Vassbotn H. -E., Al Dhuhli H., Jawa Z., Tag N., Fatima S., Imran M. B., Younis M. N., Saadullah M., Malo Y. H., Lenturut-Katal D., Castillo M., Ortellado J., Akhter A., Cader F. A., Hussain R., Khan S. R., Mandal T., Nasreen F., An Y., Cao D., Gong L., Hou Y., Jia C., Li T., Li C., Liu H., Liu W., Liu J., Ng M. -Y., Shi H., Tang C., Wang X., Wang Z., Wang Y., Wu J., Yi Y., Yuan L., Zhang T., Zhang L., Chavez E., Cruz C., Llontop C., Morales R., Abrihan P., Bustos-Barroso A., Duldulao-Ogbac M., Eduarte C., Obaldo J., Quinon A., San Juan B., San Juan C. J., Sauler-Gomez M. R., Uy M., Kostkiewicz M., Kunikowska J., Teresinska A., Urbanik T., Bettencourt N., Fontes-Carvalho R., Gavina C., Goncalves L., Macedo F., Moreno N., Sousa C., Timoteo A. T., Vidigal M. J., Al Heidous M., Ramanathan S., Arnous S., Aytani S., Byrne A., Gleeson T., Kerins D., O'Brien J., Bang J. -I., Bom H., Cheon M., Cheon G. J., Cho S. -G., Hong C. M., Jeong Y. H., Kang W. J., Kang Y. -K., Kim J. -Y., Oh S. W., So Y., Song H. -C., Won K. S., Yoo S. W., Mitevska I., Vavlukis M., Salobir B. G., Stalc M., Benedek T., Pop M., Stan C., Ansheles A., Dariy O., Gagarina N., Itskovich I., Karalkin A., Kokov A., Marina G., Migunova E., Pospelov V., Ryzhkova D., Sayfullina G., Sergienko V., Shurupova I., Vakhromeeva M., Valiullina N., Zavadovsky K., Zhuravlev K., Abazid R., Al Garni T., Alasnag M., Aljizeeri A., Amer H., Amro A., Hamdy H., Smettei O., Saranovic D. S., Vlajkovic M., Keng F., See J., Berecova Z., Mistinova J. P., Evbuomwan O., Govender N., Hack J., Hadebe B., Hlongwa K., Kaplan M., Lakhi H., Milos K., Modiselle M., More S., Muambadzi N., Scholtz L., Barreiro-Perez M., Blanco I., Broncano J., Camarero A., Casans-Tormo I., De Haro J., Flotats A., Garcia E., Mendiguchia C. G., Jimenez-Heffernan A., Leta R., Diaz J. L., Vega L. L., Manovel-Sanchez A., Monzonis A. M., Patrut B., Pubul V., Perez R. R., Zeidan N., Nanayakkara D., Suliman A., Engblom H., Murtadha M., Ostenfeld E., Simonsson M., Alkadhi H., Buechel R. R., Burger P., Grani C., Kamani C., Kawel-Bohm N., Klaeser B., Manka R., Prior J., Kaewchur T., Khiewvan B., Kositwattanarerk A., Namwongprom S., Thientunyakit T., Sayman H. B., Yuksel M., Sebikali M. J., Okello E., Korol P., Noverko I., Satyr M., Ahmad T., Alfakih K., Andrade I., Buckingham S., Bularga A., Carpenter J. -P., Cole G., Cusack D., David S., Davis P., Fairbairn T., Ghosh A., Ramkumar P. G., Hamilton M., Haque F., Hudson B., Johnstone A., Karthikeyan V. J., Kay M., Khan M. A., Kitt J., Low C. S., Mcalindon E., Mccreavy D., Morrissey B., Motwani M., Na D., Nicol E., Patel D., Rodrigues J., Rofe C., Schofield R., Semple T., Sheikh A., Sinha A., Subedi D., Topping W., Tweed K., Underwood S. R., Weir-Mccall J., Zuhairy H., Abbasi T., Abohashem S., Abramson S., Al-Mallah M., Kumar M. A., Balmer-Swain M., Berman D., Bernheim A., Bhatti S., Biederman R., Bieging E., Bingham S., Bloom S., Blue S., Borges A., Branch K., Bravo P., Buddhe S., Budoff M., Bullock-Palmer R., Cahill M., Candela C., Cao J., Chatterjee S., Chatzizisis Y., Chaudhuri N. R., Cheezum M., Chelliah A., Chen T., Chen M., Chen L., Chokshi A., Chung J., Danciu S., DeSisto W., Dilorenzo M., Doukky R., Duvall W., Ferencik M., Foster C., Fuisz A., Gannon M., German D., Gerson M., Geske J., Hage F., Haider A., Haider S., Hamirani Y., Hassen K., Hendel R., Henkel J., Horgan S., Hyun M., Janardhanan R., Jerome S., Kalra D., Kassop D., Kinkhabwala M., Kinzfogl G., Koch B., Koweek L., Krepp J., Kwon Y., Layer J., Lesser J., Leung S., Lisske B., Magurany K., Markowitz J., Mccullough B., Moalemi A., Moffitt C., Montanez J., Moore W., Morayati S., Mossa-Basha M., Mrsic Z., Murthy V., Nagpal P., Nelson K., Nijjar P., O'Quinn R., Passen E., Patil P., Pursnani A., Quachang N., Rabbat M., Ranjan P., Lozano P. R., Schemmer M., Seifried R., Shah N., Shah A., Shanbhag S., Sharma G., Skotnicki R., Sobczak M., Soman P., Sorrell V., Srichai M., Streeter J., Strickland L., Suliman S., Tebyanian N., Thomas D., Thompson R., Uretsky S., Vallurupalli S., Vandyck-Acquah M., Verma V., Villines T., Weinstein J., Wolinsky D., Zareba K., Zgaljardic M., Beretta M., Ferrando R., Kapitan M., Mut F., Djuraev O., Rozikhodjaeva G., Vera L., Duc B. D., Nguyen X. C., and Hiep Nguyen P. M.
- Abstract
Background: The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown. Objectives: The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care providers worldwide. Methods: The International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular diagnostic care at the pandemic's onset and 1 year later. Multivariable regression was used to determine factors associated with procedure volume recovery. Results: Surveys were submitted from 669 centers in 107 countries. Worldwide reduction in cardiac procedure volumes of 64% from March 2019 to April 2020 recovered by April 2021 in high- and upper middle-income countries (recovery rates of 108% and 99%) but remained depressed in lower middle- and low-income countries (46% and 30% recovery). Although stress testing was used 12% less frequently in 2021 than in 2019, coronary computed tomographic angiography was used 14% more, a trend also seen for other advanced cardiac imaging modalities (positron emission tomography and magnetic resonance; 22%-25% increases). Pandemic-related psychological stress was estimated to have affected nearly 40% of staff, impacting patient care at 78% of sites. In multivariable regression, only lower-income status and physicians’ psychological stress were significant in predicting recovery of cardiac testing. Conclusions: Cardiac diagnostic testing has yet to recover to prepandemic levels in lower-income countries. Worldwide, the decrease in standard stress testing is offset by greater use of advanced cardiac imaging modalities. Pandemic-related psychological stress among providers is widespread and associated with poor recovery of cardiac testing.
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- 2022
16. It is not too late for ... percutaneous angiography in a 90-plus population
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Costa, C, primary, Amador, A, additional, Calvao, J, additional, Pinto, R, additional, Proenca, T, additional, Carvalho, M, additional, Cabrita, A, additional, Marques, C, additional, Oliveira, C, additional, Santos, L, additional, Silva, M, additional, Silva, J, additional, and Macedo, F, additional
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- 2023
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17. The relationship of kinesiophobia in patients with lymphedema: a case-control investigation.
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Monteiro AJ, de Labra C, Losa-Iglesias ME, Dias A, Becerro-de-Bengoa-Vallejo R, Silva-Migueis H, Macedo F, López-López D, and Gómez-Salgado J
- Abstract
Introduction: Kinesiophobia and lymphedema appear to be related conditions, and it is important to understand this relationship, as many of the symptoms and comorbidities presented by individuals with lower limb lymphedema are prevented and treated through movement, thus constituting kinesiophobia as a barrier to intervention. The objective of this study is, therefore, to evaluate and analyze the kinesiophobic beliefs reported by individuals with and without lower limb lymphedema, regarding the agreement, severity and differences found, and to establish levels of kinesiophobia., Methods: A case-control study with a total sample of 80 participants (40 with lower limb lymphedema and 40 without) was performed. Both groups (with and without lymphedema) were characterized anthropologically, sociodemographically, and clinically. In the case group, lymphedema was evaluated. Participants in both groups completed the Tampa Scale for Kinesiophobia - 13 items (TSK-13)., Results: Individuals with lower limb lymphedema had higher TSK-13 scores than their matched group without lymphedema. The items belonging to the activity avoidance subscale had the highest agreement and score in both groups. Differences between groups were mainly established for items belonging to the somatic focus subscale, showing that individuals with lower limb lymphedema have kinesiophobic beliefs related to the perceived severity of their lymphedema. The prevalence of kinesiophobia was increased in both groups, but the severity was mild., Conclusions: Considering the apparent tendency of people with lower limb lymphedema to present kinesiophobia and movement-limiting beliefs regarding the condition, greater attention should be paid to its assessment, prevention and treatment from a multidisciplinary and multimodal perspective, which takes into account the multiplicity of factors inherent to kinesiophobia and lymphedema and thus reduce their impact on the management of lymphedema., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Monteiro, de Labra, Losa-Iglesias, Dias, Becerro-de-Bengoa-Vallejo, Silva-Migueis, Macedo, López-López and Gómez-Salgado.)
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- 2024
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18. Pericardial hemangioma - Imaging with pathologic correlation of an extremely rare mediastinal lesion.
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Barros Alves F, Ribeiro Morgado M, Carvalho A, Vasconcelos M, Rodrigues-Pereira P, Alves S, Macedo F, and Madureira AJ
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- Humans, Pericardium diagnostic imaging, Pericardium pathology, Hemangioma diagnostic imaging, Hemangioma pathology
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- 2024
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19. SA28 Unique Device Identifiers for Cardiac Implantable Electronic Devices – A Data Quality Assessment of Administrative Hospital Data in Portugal
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Couto, S, primary, Lobo, M, additional, Lopes, F, additional, Silva Cardoso, JC, additional, Moreira, E, additional, Rocha, A, additional, Macedo, F, additional, and Freitas, A, additional
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- 2022
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20. Long-term success in percutaneous valve commissurotomy – is Wilkins score over 9 a definitive limit?
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Martins De Carvalho, M, primary, Alves Pinto, R, additional, Proenca, T, additional, Calvao, J, additional, Martins Da Costa, C, additional, Amador, A F, additional, Amaral Marques, C, additional, Cabrita, A, additional, Santos, L, additional, Oliveira, C, additional, Pinho, A, additional, Sousa, C, additional, Paiva, M, additional, Silva, J C, additional, and Macedo, F, additional
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- 2022
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21. Patient delay in acute myocardial infarction: a long journey still ahead
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Marques, C, primary, Cabrita, A, additional, Maia Araujo, P, additional, Proenca, T, additional, Pinto, R, additional, Carvalho, M, additional, Costa, C, additional, Amador, A F, additional, Calvao, J, additional, Pinho, A, additional, Oliveira, C, additional, Santos, L, additional, Cruz, C, additional, and Macedo, F, additional
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- 2022
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22. Acute total occlusion of the unprotected left main coronary artery – patient characteristics and outcomes
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Calvao, J, primary, Braga, M, additional, Brandao, M, additional, Campinas, A, additional, Alexandre, A, additional, Amador, A F, additional, Costa, C, additional, Carvalho, M M, additional, Pinto, R A, additional, Proenca, T, additional, Silva, J C, additional, Pires-Morais, G, additional, Silva, M P, additional, Brochado, B, additional, and Macedo, F, additional
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- 2022
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23. Aortic valve calcium score: does it correlate with mean transaortic gradient?
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Amador, A, primary, Martins Da Costa, C, additional, Calvao, J, additional, Carvalho, J M, additional, Proenca, T, additional, Pinto, R, additional, Marques, C, additional, Cabrita, A, additional, Santos, L, additional, Oliveira, C, additional, Pinho, A, additional, Palma, P, additional, Rocha, M, additional, Sousa, C, additional, and Macedo, F, additional
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- 2022
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24. “Innocent” ventricular arrhythmia – can cardiovascular magnetic resonance augment diagnosis of structural heart disease?
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Costa, C, primary, Calvao, J, additional, Amador, J, additional, Proenca, T, additional, Carvalho, M, additional, Pinto, R, additional, Cabrita, A, additional, Marques, C, additional, Oliveira, C, additional, Santos, L, additional, Pinho, A, additional, Madureira, A J, additional, Lebreiro, A, additional, Pinho, T, additional, and Macedo, F, additional
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- 2022
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25. Percutaneous valve commissurotomy in mitral stenosis patients: a 20 years follow-up
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Alves Pinto, R, primary, Martins Carvalho, M, additional, Proenca, T, additional, Costa, C, additional, Amador, A F, additional, Calvao, J, additional, Marques, C, additional, Cabrita, A, additional, Santos, L, additional, Pinho, A, additional, Oliveira, C, additional, Paiva, M, additional, Silva, J C, additional, and Macedo, F, additional
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- 2022
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26. 20 year-follow up of mitral stenosis patients after percutaneous valve commissurotomy: moderate disease of other valves as predictor for re-intervention
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Amador, A, primary, Martins Da Costa, C, additional, Calvao, C, additional, Pinto, R, additional, Proenca, T, additional, Carvalho, J M, additional, Cabrita, A, additional, Marques, C, additional, Pinho, A, additional, Santos, L, additional, Oliveira, C, additional, Palma, P, additional, Paiva, M, additional, Silva, J C, additional, and Macedo, F, additional
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- 2022
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27. Reduced 3D-left atrium ejection fraction predicts development of atrial fibrillation in patients with hypertrophic cardiomyopathy
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Amador, A, primary, Martins Da Costa, C, additional, Calvao, J, additional, Pinto, R, additional, Proenca, T, additional, Carvalho, J M, additional, Cabrita, A, additional, Marques, C, additional, Pinho, A, additional, Santos, L, additional, Oliveira, C, additional, Moreira, H, additional, Palma, P, additional, Sousa, C, additional, and Macedo, F, additional
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- 2022
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28. International Curriculum for Nurses Working with Respiratory Patients - Why do we Need it? A Portuguese Perspective
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Dos Santos Castro Padilha, J M, primary, Silva, R P, additional, Macedo, F, additional, Gaspar, L, additional, and Rocha, B, additional
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- 2022
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29. First description of Portuguese patients with cardiac amyloidosis and p.Val142Ile: more evidence of an "African variant" in Caucasians.
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da Costa CM, Amador AF, Calvão J, Vasconcelos Porto A, Fernandes S, Martins E, and Macedo F
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- Male, Humans, Aged, Portugal epidemiology, Amyloid Neuropathies, Familial diagnosis, Amyloid Neuropathies, Familial epidemiology, Amyloid Neuropathies, Familial genetics, Heart Failure
- Abstract
Objectives. Hereditary transthyretin amyloidosis caused by the (ATTRv) p. Val142Ile variant is a common cause of cardiac amyloidosis among Western African countries and Afro-Americans populations. However, in recent years, Caucasian patients have been identified in greater numbers, raising the question of whether this variant has been undeappreciated in this population. We now have new cases of cardiac amyloidosis caused by the p.Val142Ile from a center in northern Portugal. In addition, we reviewed and discussed the published data concerning p.Val142Ile in Caucasians. Design. Patients diagnosed with cardiac amyloidosis underwent genetic testing using TTR gene sequencing and their relatives were recommended for genetic counsellingand testing if a pathogenic TTR variant was found. In our center, we reviewed the clinical data of patients who had the p.Val142Ile variant. A review of published cases of p.Val142Ile in Caucasians was also performed, to which our data was compared. Results. We found three ATTRv patients with the p.Val142Ile variant (one homozygotic), all Caucasian males with a median age at diagnosis of 69 years old. All of them had heart failure and arrhythmias. During the follow-up period, two patients died. There were 47 unrelated unrelated Caucasian cases of ATTRv p.Val142Ile variant reported worldwide until May 2022. Conclusions . Our findings add to the mounting evidence that the global prevalence of p.Val142Ile is likely understated. This highlights the importance of the systematic screening of the TTR gene in amyloidosis and phenocopies, as well as larger epidemiologic studies to determine the true ATTRv p.Val142Ile prevalence in non-African communities.
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- 2023
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30. [Nonverbal communication in the health care process].
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Abarca Macedo F, Tapia Cruz M, and Pari Yana Y
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- Humans, Health Facilities, Communication, Nonverbal Communication, Delivery of Health Care
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- 2023
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31. Treatment of intracardiac thrombi using ultra-slow low-dose thrombolytic therapy: A case report.
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Alves Pinto R, Torres S, Formigo M, Sousa E, Coentrão L, Neves A, Macedo F, Maciel MJ, and Oliveira T
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- Male, Humans, Middle Aged, Heparin therapeutic use, Thrombolytic Therapy adverse effects, Thrombolytic Therapy methods, Heart Diseases etiology, Thrombosis drug therapy, Thrombosis etiology, Thromboembolism, Pulmonary Embolism drug therapy
- Abstract
A 57-year-old male with previously known severe primary mitral regurgitation was admitted to the intensive care unit (ICU) due to massive venous thromboembolism, associated with right ventricular dysfunction and two large mobile right atrial thrombi. Due to deterioration in his clinical condition despite standard treatment with unfractionated heparin, it was decided to use an ultra-slow low-dose thrombolysis protocol, which consisted of a 24-hour infusion of 24 mg of alteplase at a rate of 1 mg per hour, without initial bolus. The treatment was continued for 48 consecutive hours, with clinical improvement and resolution of the intracardiac thrombi and no complications. One month after ICU admission, successful mitral valve repair surgery was conducted. This case demonstrates that ultra-slow low-dose thrombolysis is a valid bailout treatment option in patients with large intracardiac thrombi refractory to the standard approach., (Copyright © 2023. Publicado por Elsevier España, S.L.U.)
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- 2023
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32. Expert perspectives on strategic factors for the management and prevention of heart failure in Portugal.
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Caldeira D, Brito D, Aguiar C, Silva Cardoso J, Fonseca C, Franco F, Macedo F, Moura B, Pinto FJ, and Vaz-Carneiro A
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- Humans, Portugal epidemiology, Prognosis, Stroke Volume, Transition to Adult Care, Heart Failure prevention & control, Heart Failure drug therapy, Cardiac Rehabilitation
- Abstract
Introduction and Objectives: Heart failure (HF) has significant morbidity and mortality, and its prevalence will continue to increase in the future. This unfavorable evolution requires reflection as well as recommendations and decisions based on expert critical and strategic appraisal., Methods: In the Acceleration on Heart Failure Empowerment and Awareness - the Portuguese Challenge (ATHENA-PT) study, a range of strategic factors that represent the strengths, weaknesses, threats, and opportunities (SWOT) of HF in Portugal were established. These factors were assessed quantitatively by experts, to create a final SWOT matrix for the management and prevention of HF in Portugal and to outline recommendations., Results: For HF management, the panel emphasized the following strategic recommendations: (i) reimbursement of natriuretic peptides testing in primary healthcare; (ii) reimbursement of Doppler assessment in echocardiographic studies and promotion of detailed information in reports; (iii) intervention to improve the prognosis of patients with HF with preserved ejection fraction; (iv) ensuring effective healthcare transition between hospital and ambulatory units, using checklists/protocols; and (v) reinforcement and commitment to the training of primary health physicians and to the cardiac rehabilitation of patients. For the prevention of HF, the following recommendations/proposals were proposed: (i) campaigns to raise awareness of cardiovascular disease risk factors; (ii) promotion of physical exercise and healthy eating; and (iii) avoidance of therapeutic inertia in the management of risk factors., Conclusions: The acknowledgment of various strategic factors and their prioritization by experts made it possible to create and reinforce a range of new strategic recommendations for the management and prevention of HF., (Copyright © 2023 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.)
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- 2023
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33. Zika, chikungunya and co-occurrence in Brazil: space-time clusters and associated environmental-socioeconomic factors.
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Gardini Sanches Palasio R, Marques Moralejo Bermudi P, Luiz de Lima Macedo F, Reis Santana LM, and Chiaravalloti-Neto F
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- Humans, Brazil epidemiology, Socioeconomic Factors, Chikungunya Fever epidemiology, Dengue epidemiology, Zika Virus Infection epidemiology, Zika Virus
- Abstract
Chikungunya and Zika have been neglected as emerging diseases. This study aimed to analyze the space-time patterns of their occurrence and co-occurrence and their associated environmental and socioeconomic factors. Univariate (individually) and multivariate (co-occurrence) scans were analyzed for 608,388 and 162,992 cases of chikungunya and Zika, respectively. These occurred more frequently in the summer and autumn. The clusters with the highest risk were initially located in the northeast, dispersed to the central-west and coastal areas of São Paulo and Rio de Janeiro (2018-2021), and then increased in the northeast (2019-2021). Chikungunya and Zika demonstrated decreasing trends of 13% and 40%, respectively, whereas clusters showed an increasing trend of 85% and 57%, respectively. Clusters with a high co-occurrence risk have been identified in some regions of Brazil. High temperatures are associated with areas at a greater risk of these diseases. Chikungunya was associated with low precipitation levels, more urbanized environments, and places with greater social inequalities, whereas Zika was associated with high precipitation levels and low sewage network coverage. In conclusion, to optimize the surveillance and control of chikungunya and Zika, this study's results revealed high-risk areas with increasing trends and priority months and the role of socioeconomic and environmental factors., (© 2023. Springer Nature Limited.)
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- 2023
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34. Warmth and competence perceptions of key protagonists are associated with containment measures during the COVID-19 pandemic: Evidence from 35 countries
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Friehs, M, Kotzur, P, Kraus, C, Schemmerling, M, Herzig, J, Stanciu, A, Dilly, S, Hellert, L, Hübner, D, Rückwardt, A, Ulizcay, V, Christ, O, Brambilla, M, De Keersmaecker, J, Durante, F, Gale, J, Grigoryev, D, Igou, E, Javakhishvili, N, Kienmoser, D, Nicolas, G, Oldmeadow, J, Rohmer, O, Sætrevik, B, Barbedor, J, Bastias, F, Bjørkheim, S, Bolatov, A, Duran, N, Findor, A, Götz, F, Graf, S, Hakobjanyan, A, Halkias, G, Hancheva, C, Hřebíčková, M, Hruška, M, Husnu, S, Kadirov, K, Khachatryan, N, Macedo, F, Makashvili, A, Martínez-Muñoz, M, Mercadante, E, Mesesan Schmitz, L, Michael, A, Mullabaeva, N, Neto, F, Neto, J, Ozturk, M, Paschenko, S, Pietraszkiewicz, A, Psaltis, C, Qiu, Y, Rupar, M, Samekin, A, Schmid, K, Sczesny, S, Sun, Y, Svedholm-Häkkinen, A, Szymkow, A, Teye-Kwadjo, E, Torres, C, Vieira, L, Yahiiaiev, I, Yzerbyt, V, Friehs, Maria-Therese, Kotzur, Patrick F, Kraus, Christine, Schemmerling, Moritz, Herzig, Jessica A, Stanciu, Adrian, Dilly, Sebastian, Hellert, Lisa, Hübner, Doreen, Rückwardt, Anja, Ulizcay, Veruschka, Christ, Oliver, Brambilla, Marco, De Keersmaecker, Jonas, Durante, Federica, Gale, Jessica, Grigoryev, Dmitry, Igou, Eric R, Javakhishvili, Nino, Kienmoser, Doris, Nicolas, Gandalf, Oldmeadow, Julian, Rohmer, Odile, Sætrevik, Bjørn, Barbedor, Julien, Bastias, Franco, Bjørkheim, Sebastian B, Bolatov, Aidos, Duran, Nazire, Findor, Andrej, Götz, Friedrich, Graf, Sylvie, Hakobjanyan, Anna, Halkias, Georgios, Hancheva, Camellia, Hřebíčková, Martina, Hruška, Matej, Husnu, Shenel, Kadirov, Kamoliddin, Khachatryan, Narine, Macedo, Francisco G, Makashvili, Ana, Martínez-Muñoz, Maylin, Mercadante, Eric, Mesesan Schmitz, Luiza, Michael, Andreas, Mullabaeva, Nozima, Neto, Félix, Neto, Joana, Ozturk, Merve, Paschenko, Svitlana, Pietraszkiewicz, Agnieszka, Psaltis, Charis, Qiu, Yuting, Rupar, Mirjana, Samekin, Adil, Schmid, Katharina, Sczesny, Sabine, Sun, Yiwen, Svedholm-Häkkinen, Annika M, Szymkow, Aleksandra, Teye-Kwadjo, Enoch, Torres, Claudio V, Vieira, Luc, Yahiiaiev, Illia, Yzerbyt, Vincent, Friehs, M, Kotzur, P, Kraus, C, Schemmerling, M, Herzig, J, Stanciu, A, Dilly, S, Hellert, L, Hübner, D, Rückwardt, A, Ulizcay, V, Christ, O, Brambilla, M, De Keersmaecker, J, Durante, F, Gale, J, Grigoryev, D, Igou, E, Javakhishvili, N, Kienmoser, D, Nicolas, G, Oldmeadow, J, Rohmer, O, Sætrevik, B, Barbedor, J, Bastias, F, Bjørkheim, S, Bolatov, A, Duran, N, Findor, A, Götz, F, Graf, S, Hakobjanyan, A, Halkias, G, Hancheva, C, Hřebíčková, M, Hruška, M, Husnu, S, Kadirov, K, Khachatryan, N, Macedo, F, Makashvili, A, Martínez-Muñoz, M, Mercadante, E, Mesesan Schmitz, L, Michael, A, Mullabaeva, N, Neto, F, Neto, J, Ozturk, M, Paschenko, S, Pietraszkiewicz, A, Psaltis, C, Qiu, Y, Rupar, M, Samekin, A, Schmid, K, Sczesny, S, Sun, Y, Svedholm-Häkkinen, A, Szymkow, A, Teye-Kwadjo, E, Torres, C, Vieira, L, Yahiiaiev, I, Yzerbyt, V, Friehs, Maria-Therese, Kotzur, Patrick F, Kraus, Christine, Schemmerling, Moritz, Herzig, Jessica A, Stanciu, Adrian, Dilly, Sebastian, Hellert, Lisa, Hübner, Doreen, Rückwardt, Anja, Ulizcay, Veruschka, Christ, Oliver, Brambilla, Marco, De Keersmaecker, Jonas, Durante, Federica, Gale, Jessica, Grigoryev, Dmitry, Igou, Eric R, Javakhishvili, Nino, Kienmoser, Doris, Nicolas, Gandalf, Oldmeadow, Julian, Rohmer, Odile, Sætrevik, Bjørn, Barbedor, Julien, Bastias, Franco, Bjørkheim, Sebastian B, Bolatov, Aidos, Duran, Nazire, Findor, Andrej, Götz, Friedrich, Graf, Sylvie, Hakobjanyan, Anna, Halkias, Georgios, Hancheva, Camellia, Hřebíčková, Martina, Hruška, Matej, Husnu, Shenel, Kadirov, Kamoliddin, Khachatryan, Narine, Macedo, Francisco G, Makashvili, Ana, Martínez-Muñoz, Maylin, Mercadante, Eric, Mesesan Schmitz, Luiza, Michael, Andreas, Mullabaeva, Nozima, Neto, Félix, Neto, Joana, Ozturk, Merve, Paschenko, Svitlana, Pietraszkiewicz, Agnieszka, Psaltis, Charis, Qiu, Yuting, Rupar, Mirjana, Samekin, Adil, Schmid, Katharina, Sczesny, Sabine, Sun, Yiwen, Svedholm-Häkkinen, Annika M, Szymkow, Aleksandra, Teye-Kwadjo, Enoch, Torres, Claudio V, Vieira, Luc, Yahiiaiev, Illia, and Yzerbyt, Vincent
- Abstract
It is crucial to understand why people comply with measures to contain viruses and their effects during pandemics. We provide evidence from 35 countries (Ntotal = 12,553) from 6 continents during the COVID-19 pandemic (between 2021 and 2022) obtained via cross-sectional surveys that the social perception of key protagonists on two basic dimensions—warmth and competence—plays a crucial role in shaping pandemic-related behaviors. Firstly, when asked in an open question format, heads of state, physicians, and protest movements were universally identified as key protagonists across countries. Secondly, multiple-group confirmatory factor analyses revealed that warmth and competence perceptions of these and other protagonists differed significantly within and between countries. Thirdly, internal meta-analyses showed that warmth and competence perceptions of heads of state, physicians, and protest movements were associated with support and opposition intentions, containment and prevention behaviors, as well as vaccination uptake. Our results have important implications for designing effective interventions to motivate desirable health outcomes and coping with future health crises and other global challenges.
- Published
- 2022
35. Breast cancer patients presenting with cardiotoxicity - risk factors and role of cardioprotective drugs
- Author
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Martins De Carvalho, M, primary, Proenca, T, additional, Pinto, RA, additional, Costa, I, additional, Torres, S, additional, Resende, CX, additional, Grilo, PD, additional, Amador, AF, additional, Costa, C, additional, Calvao, J, additional, Cabrita, A, additional, Marques, C, additional, Sousa, C, additional, Paiva, M, additional, and Macedo, F, additional
- Published
- 2022
- Full Text
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36. Aortic valve calcium score and peri-prothesis leaks after transcatheter aortic valve implantation: a hint?
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Amador, A, primary, Martins Da Costa, C, additional, Calvao, J, additional, Alves Pinto, R, additional, Proenca, T, additional, Carvalho, JM, additional, Cabrita, A, additional, Marques, C, additional, Grilo, PD, additional, Sousa, C, additional, and Macedo, F, additional
- Published
- 2022
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37. Can aortic calcium score predict new conduction disturbances in pos-transcatheter aortic valve implantation?
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Costa, C, primary, Calvao, J, additional, Amador, A, additional, Proenca, T, additional, Carvalho, M, additional, Pinto, R, additional, Marques, C, additional, Cabrita, A, additional, Grilo, PD, additional, Resende, CX, additional, Torres, S, additional, Sousa, C, additional, and Macedo, F, additional
- Published
- 2022
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38. Impact of severe mitral annular calcification on mitral regurgitation after transcatheter aortic valve implantation
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Calvao, J, primary, Costa, C, additional, Amador, A, additional, Pinto, R, additional, Carvalho, M, additional, Proenca, T, additional, Marques, C, additional, Cabrita, A, additional, Grilo, P, additional, Resende, C, additional, Torres, S, additional, Sousa, C, additional, and Macedo, F, additional
- Published
- 2022
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39. Transcatheter systemic atrioventricular valve-in-valve implantation in a congenitally corrected transposition of the great arteries patient.
- Author
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de Carvalho MM, Machado AP, Rodrigues RA, Silva JC, Cruz C, and Macedo F
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- Female, Humans, Pregnancy, Congenitally Corrected Transposition of the Great Arteries, Tricuspid Valve, Transposition of Great Vessels complications, Transposition of Great Vessels surgery
- Abstract
We present an asymptomatic pregnant patient with congenitally corrected transposition of the great arteries and severe atrioventricular bioprosthesis regurgitation - with increased maternal and fetal risk due to volume overload. She was considered high risk for reintervention and was submitted to an off-label post-partum transcatheter valve-in-valve implantation with a Sapiens 3 valve. The procedure was successful, and she remains asymptomatic 30 months after - and even went through another successful pregnancy.
- Published
- 2023
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40. Percutaneous implantation of a Sapiens 3 valve-in-valve in mitral position: A case report involving correction of prosthetic mitral valve regurgitation.
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Martins de Carvalho M, Alves Pinto R, Proença T, Paiva M, Sousa C, Silva JC, and Macedo F
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- Humans, Mitral Valve surgery, Treatment Outcome, Mitral Valve Insufficiency etiology, Mitral Valve Insufficiency surgery, Heart Valve Prosthesis Implantation adverse effects, Heart Valve Prosthesis
- Published
- 2023
- Full Text
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41. Antiprotozoal Activity of Benzoylthiourea Derivatives against Trypanosoma cruzi : Insights into Mechanism of Action.
- Author
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Pereira PML, Fernandes BT, Dos Santos VR, Cabral WRC, Lovo-Martins MI, Alonso L, Lancheros CAC, de Paula JC, Camargo PG, Suzukawa HT, Alonso A, Macedo F Jr, Nakamura CV, Tavares ER, de Lima Ferreira Bispo M, Yamauchi LM, Pinge-Filho P, and Yamada-Ogatta SF
- Abstract
For decades, only two nitroheterocyclic drugs have been used as therapeutic agents for Chagas disease. However, these drugs present limited effectiveness during the chronic phase, possess unfavorable pharmacokinetic properties, and induce severe adverse effects, resulting in low treatment adherence. A previous study reported that N -(cyclohexylcarbamothioyl) benzamide ( BTU-1 ), N -( tert -butylcarbamothioyl) benzamide ( BTU-2 ), and (4-bromo- N -(3-nitrophenyl) carbamothioyl benzamide ( BTU-3 ) present selective antiprotozoal activity against all developmental forms of Trypanosoma cruzi Y strain. In this study, we investigated the mechanism of action of these compounds through microscopy and biochemical analyses. Transmission electron microscopy analysis showed nuclear disorganization, changes in the plasma membrane with the appearance of blebs and extracellular arrangements, intense vacuolization, mitochondrial swelling, and formation of myelin-like structures. Biochemical results showed changes in the mitochondrial membrane potential, reactive oxygen species content, lipid peroxidation, and plasma membrane fluidity. In addition, the formation of autophagic vacuoles was observed. These findings indicate that BTU-1 , BTU-2, and BTU-3 induced profound morphological, ultrastructural, and biochemical alterations in epimastigote forms, triggering an autophagic-dependent cell death pathway.
- Published
- 2023
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42. Bilateral Synchronous Olecranon Apophyseal Fracture in a Teenager: A Case Report.
- Author
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Macedo F, Marques M, Costa J, Rocha M, Ambrosi R, and Moura J
- Abstract
Introduction: While elbow fractures are frequently observed in children, isolated apophyseal detachments of the olecranon are rare, accounting for just 1.7% of all elbow fractures in healthy children. These fractures have been found to have a large positive likelihood ratio for osteogenesis imperfecta (OI). Within the population of patients with OI, the incidence is 13.5%, with 6% sustaining bilateral fractures. There are, however, very few reports of synchronous bilateral fractures., Case Report: A 15-year-old boy sustained a bilateral olecranon apophyse fracture, AO/OTA 21u-M/7 (displaced on the right side and minimal displacement on the left) after a low-energy fall. The patient was submitted on the same day to surgical treatment (open reduction and internal fixation with AO tension band wiring technique) on the right elbow and nonoperative treatment with a cast on the left side. Exome sequencing excluded mutations related to OI., Conclusion: Apophyseal avulsion fractures of the olecranon may not be pathognomonic of OI, However, orthopedists should exercise caution and remain alert to the potential occurrence in patients who experience displaced, isolated olecranon fractures due to low-energy mechanisms, particularly if they have a history of previous fractures. The clinical genetic evaluation was recommended because of clinical suspicion of OI and because patient management can be significantly influenced by genetic testing, particularly when a genetic syndrome is identified., Competing Interests: Conflict of Interest: Nil, (Copyright: © Indian Orthopaedic Research Group.)
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- 2023
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43. The influence of N-alkyl chains in benzoyl-thiourea derivatives on urease inhibition: Soil studies and biophysical and theoretical investigations on the mechanism of interaction.
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Tavares MC, Dos Santos Nascimento IJ, de Aquino TM, de Oliveira Brito T, Macedo F Jr, Modolo LV, de Fátima Â, and Santos JCC
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- Humans, Urease chemistry, Urease metabolism, Fertilizers analysis, Urea chemistry, Enzyme Inhibitors pharmacology, Thiourea, Biophysics, Soil, Helicobacter pylori metabolism
- Abstract
Ureases are enzymes produced by fungi, plants, and bacteria associated with agricultural and clinical problems. The urea hydrolysis in NH
3 and CO2 leads to the loss of N-urea fertilizers in soils and changes the human stomach microenvironment, favoring the colonization of H. pylori. In this sense, it is necessary to evaluate potential enzyme inhibitors to mitigate the effects of their activities and respond to scientific and market demands to produce fertilizers with enhanced efficiency. Thus, biophysical and theoretical studies were carried out to evaluate the influence of the N-alkyl chain in benzoyl-thiourea derivatives on urease enzyme inhibition. A screening based on IC50 , binding constants, and theoretical studies demonstrated that BTU1 without the N-alkyl chain (R = H) was more active than other compounds, so the magnitude of the interaction was determined as BTU1 > BTU2 > BTU3 > BTU4 > BTU5, corresponding to progressively increased chain length. Thus, BTU1 was selected for interaction and soil application essays. The binding constants (Kb ) for the supramolecular urease-BTU1 complex ranged from 7.95 to 5.71 × 103 M-1 at different temperatures (22, 30, and 38 °C), indicating that the preferential forces responsible for the stabilization of the complex are hydrogen bonds and van der Waals forces (ΔH = -15.84 kJ mol-1 and ΔS = -36.61 J mol-1 K-1 ). Theoretical and experimental results (thermodynamics, synchronous fluorescence, and competition assay) agree and indicate that BTU1 is a mixed inhibitor. Finally, urease inhibition was evaluated in the four soil samples, where BTU1 was as efficient as NBPT (based on ANOVA two-way and Tukey test with 95% confidence), with an average inhibition of 20% of urease activity. Thus, the biophysics and theoretical studies are strategies for evaluating potential inhibitors and showed that increasing the N-alkyl chain in benzoyl-thiourea derivatives did not favor urease inhibition., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)- Published
- 2023
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44. Acute total occlusion of the unprotected left main coronary artery: Patient characteristics and outcomes.
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Calvão J, Braga M, Brandão M, Campinas A, Alexandre A, Amador A, Costa C, Silva JC, Silva M, Brochado B, Freitas J, and Macedo F
- Subjects
- Humans, Male, Middle Aged, Female, Shock, Cardiogenic etiology, Coronary Vessels, Retrospective Studies, Prognosis, Coronary Angiography, Treatment Outcome, Myocardial Infarction, Percutaneous Coronary Intervention methods
- Abstract
Introduction and Objectives: Acute total occlusion of the unprotected left main coronary artery (LMCA) is a dramatic event. There are limited data regarding this population. We aimed to describe the clinical presentation and outcomes of patients and to determine predictors of in-hospital mortality., Methods: This retrospective study included patients presenting with acute (<12 h) myocardial infarction due to total occlusion of the LMCA (TIMI flow 0) between January 2008 and December 2020 in three tertiary hospitals., Results: During this period, 11036 emergent coronary angiographies were performed, 59 (0.5%) of which revealed acute total occlusion of the LMCA. Patients' mean age was 61.2 (SD±12.2) years and 73% were male. No patients had left dominance. At presentation, 73% were in cardiogenic shock, aborted cardiac arrest occurred in 27% and 97% underwent myocardial revascularization. Primary percutaneous coronary intervention was performed in 90% of cases and angiographic success was achieved in 56% of procedures, while 7% of patients underwent surgical revascularization. In-hospital mortality was 58%. Among survivors, 92% and 67% were alive after one and five years, respectively. After multivariate analysis, only cardiogenic shock and angiographic success were independent predictors of in-hospital mortality. Use of mechanical circulatory support and presence of well-developed collateral circulation were not predictive of short-term prognosis., Conclusion: Acute total occlusion of the LMCA is associated with a dismal prognosis. Cardiogenic shock and angiographic success play a major role in predicting the prognosis of these patients. The effect of mechanical circulatory support on patient prognosis remains to be determined., (Copyright © 2023. Publicado por Elsevier España, S.L.U.)
- Published
- 2023
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45. An Unexpected Cause of Acute Abdomen Late After Heart Transplantation-A Case Report.
- Author
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Amorim S, Araújo P, Pinto R, Medas R, Pereira P, Lopes J, Santos L, Pinheiro-Torres J, Macedo F, and Pinho P
- Subjects
- Male, Humans, Valganciclovir therapeutic use, Antiviral Agents therapeutic use, Ganciclovir therapeutic use, Abdomen, Acute etiology, Abdomen, Acute complications, Cytomegalovirus Infections complications, Cytomegalovirus Infections diagnosis, Cytomegalovirus Infections drug therapy, Heart Transplantation adverse effects, Gastrointestinal Diseases, Ampulla of Vater
- Abstract
Cytomegalovirus (CMV) infection is a frequent complication after a solid organ transplant, and in 86% of the cases, CMV disease occurred during the first 6 months after transplantation. Invasive CMV infections may be present as ulcerative infections of the upper gastrointestinal tract with esophagitis, gastritis, and ulcerations of the duodenum and the small bowel; however, CMV infections of the pancreatobiliary system, especially papillitis, are rarely observed. We present a case report of a man who underwent a heart transplant 6 years before, with a clinical picture of duodenitis and a simultaneous pseudotumor of major duodenal papilla who developed signs of acute abdomen caused by gastrointestinal CMV infection, successfully treated with medical therapy with valganciclovir. There is an urgent need for developments in CMV and solid organ transplantation to stratify the risk of late-onset CMV disease., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
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46. Cutaneous Tuberculosis in Heart Transplant.
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Lino R, Amorim S, Silva C, Neves N, Araújo P, Pinto R, Pinheiro-Torres J, Pinho P, Macedo F, and Santos L
- Subjects
- Humans, Abscess, Rifampin therapeutic use, Tuberculosis, Cutaneous diagnosis, Tuberculosis, Cutaneous drug therapy, Mycobacterium tuberculosis, Heart Transplantation adverse effects
- Abstract
Tuberculosis is a disease with a significant global burden in terms of morbidity and mortality. It usually presents as a pulmonary disease but can occasionally have extrapulmonary presentations. Immunosuppressed people are at an increased risk of tuberculosis and more frequently have atypical manifestations of the disease. Cutaneous involvement is estimated to occur in only 2% of extrapulmonary presentations. We report a case of a heart transplant recipient with disseminated tuberculosis who initially presented with cutaneous manifestations in the form of multiple abscesses that were mistaken for a community-acquired bacterial infection. The diagnosis was made after positive nucleic acid amplification testing and cultures for Mycobacterium tuberculosis from the drainage of the abscesses. After initiating antituberculous treatment, the patient had 2 instances of immune reconstitution inflammatory syndrome. A combination of diminished immunosuppression due to discontinuation of mycophenolate mofetil in the setting of acute infection, rifampin drug interactions with cyclosporine, and the beginning of treatment of tuberculosis all contributed to this paradoxical worsening. The patient responded favorably to increased glucocorticoid therapy and showed no signs of treatment failure after 6 months of antituberculous therapy., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
47. Therapeutic impact of determination of RAS mutations in the plasma of patient with colorectal cancer.
- Author
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Macedo, F., Monteiro, J., Pereira, T. Cunha, Monteiro, A. R., Soares, R. Felix, Bonito, N., and Sousa, G.
- Subjects
GENETIC mutation ,MOLECULAR diagnosis ,GENE expression ,COLORECTAL cancer ,POLYMERASE chain reaction ,EXTRACELLULAR space ,NUCLEIC acids - Abstract
Stage IV colorectal cancer treatment includes targeted therapy depending on RAS status. During disease progression, loss or gain of RAS mutations could happen, supporting the hypothesis of the evolutionary pressure of therapy. Circulating tumor DNA (ctDNA) are nucleic acids released to the bloodstream by the tumor during its development and may be detected by liquid biopsy. The Idylla© Biocartis, a fully automated real-time-PCR-based molecular diagnostic system, was used in a patient with metastatic colorectal cancer with a NRAS mutation in progression after several therapeutic lines. The ctDNA mutational analysis was performed and revealed the absence of mutations in the KRAS, NRAS, and BRAF genes. The patient started the third line of palliative chemotherapy with irinotecan + cetuximab and achieved a partial response for the first time. The authors describe a case in which liquid biopsy determined the higher progression-free survival achieved. [ABSTRACT FROM AUTHOR]
- Published
- 2022
48. DELETERIOUS EFFECT OF VICILINS FRACTIONS OF LEGUMINOUS SEEDS in vitro AND IN SEMI-FIELD CONDITIONS FOR Ceratitis capitata.
- Author
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MACEDO, C. S., FRANÇA, A. F. J., MACEDO, L. L. P., AMORIM, T. M. L., ARAÚJO, R. R. O., SANTOS, Y. Q., CARELLI, G. S. C., UCHOA, A. F., MACEDO, F. P., OLIVEIRA, A. S., SANTOS, E. A., and ARAUJO, J. N.
- Subjects
MEDITERRANEAN fruit-fly ,AFFINITY chromatography ,SEEDS ,COMMON bean ,BIOLOGICAL insecticides ,SEED proteins - Abstract
Copyright of HOLOS is the property of Instituto Federal do Rio Grande do norte - IFRN and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
49. The world upside down - after 20 years of follow-up of dextro-transposition of the great arteries.
- Author
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Alves Pinto R, Amaral Marques C, Proença T, Martins Carvalho M, Cruz C, and Macedo F
- Subjects
- Adult, Humans, Female, Male, Follow-Up Studies, Heart Atria, Arteries, Treatment Outcome, Retrospective Studies, Transposition of Great Vessels surgery, Transposition of Great Vessels complications, Atrial Flutter
- Abstract
Dextro-transposition of the great arteries (D-TGA) is a congenital heart disease (CHD) classically palliated with atrial switch (ATR-S) and nowadays corrected with arterial switch (ART-S). Our aim was to observe a group of D-TGA patients followed in an adult CHD outpatient clinic. We analyzed a group of D-TGA patients born between 1974 and 2001. Adverse events were defined as a composite of death, stroke, myocardial infarction or coronary revascularization, arrhythmia, and ventricular, baffle, or significative valvular dysfunction. A total of 79 patients were enrolled, 46% of whom were female, with a mean follow-up of 27±6 years after surgery. ATR-S was performed in 54% and ART-S in 46%; the median age at procedure was 13 months and 10 days, respectively. During follow-up, almost all ART-S remained in sinus rhythm versus 64% of ATR-S (p=0.002). The latter group had a higher incidence of arrhythmias (41% versus 3%, p<0.001), mostly atrial flutter or fibrillation; the median time to first arrhythmia was 23 years. Systemic ventricle systolic dysfunction (SVSD) was more frequent in ATR-S (41% versus 0%, p<0.001); the mean time to SVSD was 25 years. In ART-S, the most frequent complication was significant valvular regurgitation (14%). Regarding time-to-event analysis, 80% and 40% of ATR-S maintained adverse events-free after 20 and 30 years, respectively; the time-to-first adverse event was 23 years, and there was no difference compared to ART-S (Log-rank=0.596). ART-S tended to maintain more preserved biventricular function than ATR-S (Log-rank=0.055). After a long term free of adverse events, ATR-S patients experienced more arrhythmias and SVSD. ART-S complications were predominantly anastomosis-related; SVSD or arrhythmias were rare.
- Published
- 2023
- Full Text
- View/download PDF
50. Marked PR interval variability in a patient with Brugada syndrome.
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Martins de Carvalho M, Pinto RA, Proença T, Souteiro D, Adão L, Macedo F, and Campelo M
- Published
- 2023
- Full Text
- View/download PDF
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