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2. Mitochondrial DNA and Inflammation Are Associated with Cerebral Vessel Remodeling and Early Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus.

Author

Petrica, Ligia, Gadalean, Florica, Muntean, Danina Mirela, Jianu, Dragos Catalin, Vlad, Daliborca, Dumitrascu, Victor, Bob, Flaviu, Milas, Oana, Suteanu-Simulescu, Anca, Glavan, Mihaela, Ursoniu, Sorin, Balint, Lavinia, Mogos-Stefan, Maria, Ienciu, Silvia, Cretu, Octavian Marius, Popescu, Roxana, Gluhovschi, Cristina, Iancu, Lavinia, and Vlad, Adrian

Subjects
DIABETIC nephropathies, MITOCHONDRIAL DNA, TYPE 2 diabetes, CD54 antigen, NADH dehydrogenase, INTERNAL carotid artery, TUMOR necrosis factors
Abstract

Cerebrovascular disease accounts for major neurologic disabilities in patients with type 2 diabetes mellitus (DM). A potential association of mitochondrial DNA (mtDNA) and inflammation with cerebral vessel remodeling in patients with type 2 DM was evaluated. A cohort of 150 patients and 30 healthy controls were assessed concerning urinary albumin/creatinine ratio (UACR), synaptopodin, podocalyxin, kidney injury molecule-1 (KIM-1), N-acetyl-β-(D)-glucosaminidase (NAG), interleukins IL-17A, IL-18, IL-10, tumor necrosis factor-alpha (TNFα), intercellular adhesion molecule-1 (ICAM-1). MtDNA-CN and nuclear DNA (nDNA) were quantified in peripheral blood and urine by qRT-PCR. Cytochrome b (CYTB) gene, subunit 2 of NADH dehydrogenase (ND2), and beta 2 microglobulin nuclear gene (B2M) were assessed by TaqMan assays. mtDNA-CN was defined as the ratio of the number of mtDNA/nDNA copies, through analysis of the CYTB/B2M and ND2/B2M ratio; cerebral Doppler ultrasound: intima-media thickness (IMT)—the common carotid arteries (CCAs), the pulsatility index (PI) and resistivity index (RI)- the internal carotid arteries (ICAs) and middle cerebral arteries (MCAs), the breath-holding index (BHI). The results showed direct correlations of CCAs-IMT, PI-ICAs, PI-MCAs, RI-ICAs, RI-MCAs with urinary mtDNA, IL-17A, IL-18, TNFα, ICAM-1, UACR, synaptopodin, podocalyxin, KIM-1, NAG, and indirect correlations with serum mtDNA, IL-10. BHI correlated directly with serum IL-10, and serum mtDNA, and negatively with serum IL-17A, serum ICAM-1, and NAG. In neurologically asymptomatic patients with type 2 DM cerebrovascular remodeling and impaired cerebrovascular reactivity may be associated with mtDNA variations and inflammation from the early stages of diabetic kidney disease. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Mitochondrial DNA Changes in Blood and Urine Display a Specific Signature in Relation to Inflammation in Normoalbuminuric Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Author

Petrica, Ligia, primary, Vlad, Adrian, additional, Gadalean, Florica, additional, Muntean, Danina Mirela, additional, Vlad, Daliborca, additional, Dumitrascu, Victor, additional, Bob, Flaviu, additional, Milas, Oana, additional, Suteanu-Simulescu, Anca, additional, Glavan, Mihaela, additional, Jianu, Dragos Catalin, additional, Ursoniu, Sorin, additional, Balint, Lavinia, additional, Mogos-Stefan, Maria, additional, Ienciu, Silvia, additional, Cretu, Octavian Marius, additional, and Popescu, Roxana, additional

Published
2023
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