1. A LIGHT-HVEM/LTβR axis contributes to the fibrosis of intrauterine adhesion.
- Author
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Abudukeyoumu A, Lai ZZ, Lu JJ, Zhang X, Hou DY, Dong J, Wu JN, Li MQ, and Xie F
- Subjects
- Actins, Female, Fibrosis genetics, Humans, Pregnancy, Signal Transduction, Transforming Growth Factor beta1, Lymphotoxin beta Receptor genetics, Lymphotoxin beta Receptor physiology, Receptors, Tumor Necrosis Factor, Member 14 genetics, Tumor Necrosis Factor Ligand Superfamily Member 14 genetics, Uterine Diseases genetics, Uterine Diseases pathology
- Abstract
Intrauterine adhesion (IUA) is a fibrotic disease, with complex and multifactorial process, causing menstrual disorders, pregnancy loss or infertility. LIGHT (also named TNFSF14), mainly expressed by immune cells, has been reported to be associated with tissue fibrosis. However, the features of immunocyte subsets, the expression and roles of LIGHT and its receptor HVEM (herpes virus entry mediator) and LTβR (lymphotoxin beta receptor) in IUA remain largely unknown. Compared with the control group, we observed increased ratios of CD45
+ cells, neutrophils, T cells, macrophages and decreased natural killer cells proportion, and high LIGHT expression on CD4+ T cells and macrophages in IUA endometrium. Further analysis showed there was a positive correlation between upregulated profibrotic factors (e.g., ɑ-smooth muscle actin, transforming growth factor β1) and HVEM in IUA endometrial tissue. More importantly, recombinant human LIGHT protein directly up-regulated the expression of HVEM, LTβR, profibrotic and proinflammatory factors expression in human endometrial stromal cells. These findings reveal abnormal changes of immune cell subsets proportion and the overexpression of LIGHT-HVEM/LTβR axis in IUA endometrium, should contribute to inflammation and fibrosis formation of IUA., Competing Interests: Conflict of interest There are no conflict of interest in this study., (Copyright © 2022 Elsevier B.V. All rights reserved.)- Published
- 2022
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