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223 results on '"Loupy, Alexandre"'

1. Transplantation of a genetically modified porcine heart into a live human

Author

Griffith, Bartley P., Grazioli, Alison, Singh, Avneesh K., Tully, Andy, Galindo, Javier, Saharia, Kapil K., Shah, Aakash, Strauss, Erik R., Odonkor, Patrick N., Williams, Brittney, Silverman, Henry J., Burke, Allen, Drachenberg, Cinthia B., Wells, Chris L., Dickfeld, Timm, Hong, Susie N., Hicks, III, Albert J., Ananthram, Manjula, Gupta, Anuj, Christenson, Robert H., Tamburro, Lo, Zhang, Tianshu, Hershfeld, Alena, Lewis, Billeta, Feller, Erika D., Kuravi, Kasinath, Sorrells, Lori, Morgand, Erwan, Mezine, Fariza, Goutaudier, Valentin, Rothblatt, Martine, Lau, Christine L., Taylor, Bradley, Perrin, Steve, Loupy, Alexandre, Ayares, David, and Mohiuddin, Muhammad M.

Published
2025
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3. Successful prevention of BK-polyomavirus nephropathy using extracorporeal photopheresis for immunosuppression minimisation following severe BK polyomavirus replication after kidney transplantation in a double lung transplant recipient, a case report

Author

Von Tokarski, Florent, Parquin, François, Roux, Antoine, Hayem, Victor, Kerdiles, Thibault, Rabant, Marion, Isnard, Pierre, Loupy, Alexandre, Fourniol, Cyril, Tricot, Leila, Picard, Clément, Hertig, Alexandre, and Oniszczuk, Julie

Published
2024
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4. A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients

Author

Yoo, Daniel, Divard, Gillian, Raynaud, Marc, Cohen, Aaron, Mone, Tom D., Rosenthal, John Thomas, Bentall, Andrew J., Stegall, Mark D., Naesens, Maarten, Zhang, Huanxi, Wang, Changxi, Gueguen, Juliette, Kamar, Nassim, Bouquegneau, Antoine, Batal, Ibrahim, Coley, Shana M., Gill, John S., Oppenheimer, Federico, De Sousa-Amorim, Erika, Kuypers, Dirk R. J., Durrbach, Antoine, Seron, Daniel, Rabant, Marion, Van Huyen, Jean-Paul Duong, Campbell, Patricia, Shojai, Soroush, Mengel, Michael, Bestard, Oriol, Basic-Jukic, Nikolina, Jurić, Ivana, Boor, Peter, Cornell, Lynn D., Alexander, Mariam P., Toby Coates, P., Legendre, Christophe, Reese, Peter P., Lefaucheur, Carmen, Aubert, Olivier, and Loupy, Alexandre

Published
2024
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5. Cell-free DNA for the detection of kidney allograft rejection

Author

Aubert, Olivier, Ursule-Dufait, Cindy, Brousse, Romain, Gueguen, Juliette, Racapé, Maud, Raynaud, Marc, Van Loon, Elisabet, Pagliazzi, Angelica, Huang, Edmund, Jordan, Stanley C., Chavin, Kenneth D., Gupta, Gaurav, Kumar, Dhiren, Alhamad, Tarek, Anand, Sanjiv, Sanchez-Garcia, Jorge, Abdalla, Basmah A., Hogan, Julien, Garro, Rouba, Dadhania, Darshana M., Jain, Pranjal, Mandelbrot, Didier A., Naesens, Maarten, Dandamudi, Raja, Dharnidharka, Vikas R., Anglicheau, Dany, Lefaucheur, Carmen, and Loupy, Alexandre

Published
2024
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6. Validation of a prediction system for risk of kidney allograft failure in pediatric kidney transplant recipients: An international observational study.

Author

Hogan, Julien, Divard, Gillian, Aubert, Olivier, Garro, Rouba, Boyer, Olivia, Donald Cooper, Lee, Farris, Alton, Fila, Marc, Seifert, Michael, Sellier-Leclerc, Anne-Laure, Smith, Jody, Fichtner, Alexander, Tönshoff, Burkhard, Twombley, Katherine, Warady, Bradley, Pearl, Meghan, Zahr, Rima, Lefaucheur, Carmen, Patzer, Rachel, and Loupy, Alexandre

Subjects
Banff classification, allograft failure, children, kidney transplantation, predictive model, Adult, Humans, Child, United States, Kidney Transplantation, Creatinine, Transplantation, Homologous, Kidney, Renal Insufficiency, Glomerular Filtration Rate, Transplant Recipients, Allografts
Abstract

Predicting long-term kidney allograft failure is an unmet need for clinical care and clinical trial optimization in children. We aimed to validate a kidney allograft failure risk prediction system in a large international cohort of pediatric kidney transplant recipients. Patients from 20 centers in Europe and the United States, transplanted between 2004 and 2017, were included. Allograft assessment included estimated glomerular filtration rate, urine protein-to-creatinine ratio, circulating antihuman leukocyte antigen donor-specific antibody, and kidney allograft histology. Individual predictions of allograft failure were calculated using the integrative box (iBox) system. Prediction performances were assessed using discrimination and calibration. The allograft evaluations were performed in 706 kidney transplant recipients at a median time of 9.1 (interquartile range, 3.3-19.2) months posttransplant; mean estimated glomerular filtration rate was 68.7 ± 28.1 mL/min/1.73 m2, and median urine protein-to-creatinine ratio was 0.1 (0.0-0.4) g/g, and 134 (19.0%) patients had antihuman leukocyte antigen donor-specific antibodies. The iBox exhibited accurate calibration and discrimination for predicting the outcomes up to 10 years after evaluation, with a C-index of 0.81 (95% confidence interval, 0.75-0.87). This study confirms the generalizability of the iBox to predict long-term kidney allograft failure in children, with performances similar to those reported in adults. These results support the use of the iBox to improve patient monitoring and facilitate clinical trials in children.

Published
2023

7. Integrative multi-omics profiling in human decedents receiving pig heart xenografts

Author

Schmauch, Eloi, Piening, Brian, Mohebnasab, Maedeh, Xia, Bo, Zhu, Chenchen, Stern, Jeffrey, Zhang, Weimin, Dowdell, Alexa K., Kim, Jacqueline I., Andrijevic, David, Khalil, Karen, Jaffe, Ian S., Loza, Bao-Li, Gragert, Loren, Camellato, Brendan R., Oliveira, Michelli F., O’Brien, Darragh P., Chen, Han M., Weldon, Elaina, Gao, Hui, Gandla, Divya, Chang, Andrew, Bhatt, Riyana, Gao, Sarah, Lin, Xiangping, Reddy, Kriyana P., Kagermazova, Larisa, Habara, Alawi H., Widawsky, Sophie, Liang, Feng-Xia, Sall, Joseph, Loupy, Alexandre, Heguy, Adriana, Taylor, Sarah E. B., Zhu, Yinan, Michael, Basil, Jiang, Lihua, Jian, Ruiqi, Chong, Anita S., Fairchild, Robert L., Linna-Kuosmanen, Suvi, Kaikkonen, Minna U., Tatapudi, Vasishta, Lorber, Marc, Ayares, David, Mangiola, Massimo, Narula, Navneet, Moazami, Nader, Pass, Harvey, Herati, Ramin S., Griesemer, Adam, Kellis, Manolis, Snyder, Michael P., Montgomery, Robert A., Boeke, Jef D., and Keating, Brendan J.

Published
2024
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8. Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection

Author

Goutaudier, Valentin, Sablik, Marta, Racapé, Maud, Rousseau, Olivia, Audry, Benoit, Kamar, Nassim, Raynaud, Marc, Aubert, Olivier, Charreau, Béatrice, Papuchon, Emmanuelle, Danger, Richard, Letertre, Laurence, Couzi, Lionel, Morelon, Emmanuel, Le Quintrec, Moglie, Taupin, Jean-Luc, Vicaut, Eric, Legendre, Christophe, Le Mai, Hoa, Potluri, Vishnu, Nguyen, Thi-Van-Ha, Azoury, Marie-Eliane, Pinheiro, Alice, Nouadje, Georges, Sonigo, Pierre, Anglicheau, Dany, Tieken, Ineke, Vogelaar, Serge, Jacquelinet, Christian, Reese, Peter, Gourraud, Pierre-Antoine, Brouard, Sophie, Lefaucheur, Carmen, and Loupy, Alexandre

Published
2024
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9. Banff Digital Pathology Working Group: Image Bank, Artificial Intelligence Algorithm, and Challenge Trial Developments.

Author

Farris, Alton, Alexander, Mariam, Balis, Ulysses, Barisoni, Laura, Boor, Peter, Bülow, Roman, Cornell, Lynn, Demetris, Anthony, Farkash, Evan, Hermsen, Meyke, Hogan, Julien, Kain, Renate, Kers, Jesper, Kong, Jun, Levenson, Richard, Loupy, Alexandre, Naesens, Maarten, Sarder, Pinaki, Tomaszewski, John, van der Laak, Jeroen, van Midden, Dominique, Yagi, Yukako, and Solez, Kim

Subjects
Banff, artificial intelligence, digital pathology, image analysis, machine learning, Humans, Artificial Intelligence, Algorithms, Kidney Transplantation, Kidney
Abstract

The Banff Digital Pathology Working Group (DPWG) was established with the goal to establish a digital pathology repository; develop, validate, and share models for image analysis; and foster collaborations using regular videoconferencing. During the calls, a variety of artificial intelligence (AI)-based support systems for transplantation pathology were presented. Potential collaborations in a competition/trial on AI applied to kidney transplant specimens, including the DIAGGRAFT challenge (staining of biopsies at multiple institutions, pathologists visual assessment, and development and validation of new and pre-existing Banff scoring algorithms), were also discussed. To determine the next steps, a survey was conducted, primarily focusing on the feasibility of establishing a digital pathology repository and identifying potential hosts. Sixteen of the 35 respondents (46%) had access to a server hosting a digital pathology repository, with 2 respondents that could serve as a potential host at no cost to the DPWG. The 16 digital pathology repositories collected specimens from various organs, with the largest constituent being kidney (n = 12,870 specimens). A DPWG pilot digital pathology repository was established, and there are plans for a competition/trial with the DIAGGRAFT project. Utilizing existing resources and previously established models, the Banff DPWG is establishing new resources for the Banff community.

Published
2023

10. Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)

Author

Goutaudier, Valentin, Danger, Richard, Catar, Rusan Ali, Racapé, Maud, Philippe, Aurélie, Elias, Michelle, Raynaud, Marc, Aubert, Olivier, Bouton, Didier, Girardin, François, Vicaut, Éric, Yaiche, Sarhan, Demotes, Jacques, Heidecke, Harald, Taupin, Jean-Luc, Randoux-Lebrun, Christine, Zaidan, Mohamad, Papuchon, Emmanuelle, Le Mai, Hoa, Nguyen, Thi-Van-Ha, Moreso, Francesc, Berney, Thierry, Villard, Jean, Legendre, Christophe, Dragun, Duska, Papalois, Vassilios, Potena, Luciano, Giral, Magali, Gourraud, Pierre-Antoine, Brouard, Sophie, Crespo, Elena, Halleck, Fabian, Budde, Klemens, Bestard, Oriol, Loupy, Alexandre, and Lefaucheur, Carmen

Published
2024
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12. High-dimensional mass cytometry identified circulating natural killer T-cell subsets associated with protection from cytomegalovirus infection in kidney transplant recipients

Author

Donadeu, Laura, Jouve, Thomas, Bin, Sofia, Hartzell, Susan, Crespo, Elena, Torija, Alba, Jarque, Marta, Kervella, Delphine, Zúñiga, José, Zhang, Weijia, Sun, Zeguo, Verlato, Alberto, Martínez-Gallo, Mónica, Font-Miñarro, Cristina, Meneghini, Maria, Toapanta, Nestor, Torres, Irina B., Sellarés, Joana, Perelló, Manel, Kaminski, Hannah, Couzi, Lionel, Loupy, Alexandre, La Manna, Gaetano, Moreso, Francesc, Cravedi, Paolo, and Bestard, Oriol

Published
2024
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14. Identification of liver transplant biopsy phenotypes associated with distinct liver biological markers and allograft survival

Author

Demir, Zeynep, Raynaud, Marc, Aubert, Olivier, Debray, Dominique, Sebagh, Mylène, Duong Van Huyen, Jean-Paul, Del Bello, Arnaud, Jolivet, Nicolas Congy, Paradis, Valérie, Durand, François, Muratot, Sophie, Lozach, Cécile, Chardot, Christophe, Francoz, Claire, Kamar, Nassim, Sarnacki, Sabine, Coilly, Audrey, Samuel, Didier, Vibert, Eric, Féray, Cyrille, Lefaucheur, Carmen, and Loupy, Alexandre

Published
2024
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15. Long-term Kidney Transplant Survival Across the Globe

Author

Hariharan, Sundaram, Rogers, Natasha, Naesens, Maarten, Pestana, J. Medina, Ferreira, Gustavo F., Requião-Moura, Lucio R., Foresto, Renato D., Kim, S. Joseph, Sullivan, Katrina, Helanterä, Ilkka, Goutaudier, Valentin, Loupy, Alexandre, Kute, Vivek B., Cardillo, Massimo, Tanabe, Kazunari, Åsberg, Anders, Jensen, Trond, Mahillo, Beatriz, Jeong, Jong Cheol, Anantharaman, Vathsala, Callaghan, Chris, Ravanan, Rommel, Manas, Derek, Israni, Ajay K., and Mehta, Rajil B.

Published
2024
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17. The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, and Mengel, Michael

Published
2024
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18. The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics

Author

Naesens, Maarten, Roufosse, Candice, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Adam, Benjamin A., Aubert, Olivier, Böhmig, Georg A., Callemeyn, Jasper, Clahsen-van Groningen, Marian, Cornell, Lynn D., Demetris, Anthony J., Drachenberg, Cinthia B., Einecke, Gunilla, Fogo, Agnes B., Gibson, Ian W., Halloran, Philip, Hidalgo, Luis G., Horsfield, Catherine, Huang, Edmund, Kikić, Željko, Kozakowski, Nicolas, Nankivell, Brian, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Sapir-Pichhadze, Ruth, Schinstock, Carrie, Solez, Kim, Tambur, Anat R., Thaunat, Olivier, Wiebe, Chris, Zielinski, Dina, Colvin, Robert, Loupy, Alexandre, and Mengel, Michael

Published
2024
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20. Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Ahn, Curie, Alberú, Josefina, Baliker, Mary, Bamgboye, Ebun L., Barber, Thelma, Bensouda, Melissa, Chadban, Steve J., Dadhania, Darshana M., Dębska-Ślizień, Alicja, Devresse, Arnaud, Ditzen, Beate, Fowler, Kevin, Gill, John S., Jha, Vivekanand, Khairallah, Pascale, Knoll, Greg A., Korst, Uwe, Lee, Austin, Legendre, Christophe, Lentine, Krista L., Lerma, Edgar V., Lorenz, Elizabeth C., Matas, Arthur J., Mohan, Sumit, Nazarewski, Sławomir, Noronha, Irene L., Obrador, Gregorio T., Parekh, Rulan S., Pavlakis, Martha, Pascual, Julio, Pilmore, Helen L., Rosenkranz, Alexander R., Rozen-Zvi, Benaya, Roy-Chaudhury, Prabir, Tanabe, Kazunari, Wanner, Christoph, Wasse, Haimanot, Yang, Chul-Woo, Josephson, Michelle A., Becker, Yolanda, Budde, Klemens, Kasiske, Bertram L., Kiberd, Bryce A., Loupy, Alexandre, Małyszko, Jolanta, Mannon, Roslyn B., Tönshoff, Burkhard, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., and Zeier, Martin

Published
2023
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21. An automated histological classification system for precision diagnostics of kidney allografts

Author

Yoo, Daniel, Goutaudier, Valentin, Divard, Gillian, Gueguen, Juliette, Astor, Brad C., Aubert, Olivier, Raynaud, Marc, Demir, Zeynep, Hogan, Julien, Weng, Patricia, Smith, Jodi, Garro, Rouba, Warady, Bradley A., Zahr, Rima S., Sablik, Marta, Twombley, Katherine, Couzi, Lionel, Berney, Thierry, Boyer, Olivia, Duong-Van-Huyen, Jean-Paul, Giral, Magali, Alsadi, Alaa, Gourraud, Pierre A., Morelon, Emmanuel, Le Quintrec, Moglie, Brouard, Sophie, Legendre, Christophe, Anglicheau, Dany, Villard, Jean, Zhong, Weixiong, Kamar, Nassim, Bestard, Oriol, Djamali, Arjang, Budde, Klemens, Haas, Mark, Lefaucheur, Carmen, Rabant, Marion, and Loupy, Alexandre

Published
2023
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25. Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study

Author

Loupy, Alexandre, Goutaudier, Valentin, Giarraputo, Alessia, Mezine, Fariza, Morgand, Erwan, Robin, Blaise, Khalil, Karen, Mehta, Sapna, Keating, Brendan, Dandro, Amy, Certain, Anaïs, Tharaux, Pierre-Louis, Narula, Navneet, Tissier, Renaud, Giraud, Sébastien, Hauet, Thierry, Pass, Harvey I, Sannier, Aurélie, Wu, Ming, Griesemer, Adam, Ayares, David, Tatapudi, Vasishta, Stern, Jeffrey, Lefaucheur, Carmen, Bruneval, Patrick, Mangiola, Massimo, and Montgomery, Robert A

Published
2023
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26. Subclinical rejection-free diagnostic after kidney transplantation using blood gene expression

Author

Badet, Lionel, Brunet, Maria, Buron, Fanny, Cahen, Rémi, Codas, Ricardo, Daoud, Sameh, Dubois, Valérie, Fournie, Coralie, Gaillard, François, Grégoire, Arnaud, Koenig, Alice, Lévi, Charlène, Morelon, Emmanuel, Pouteil-Noble, Claire, Rabeyrin, Maud, Rimmelé, Thomas, Thaunat, Olivier, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Chapelet, Agnès, Dantal, Jacques, Deltombe, Clément, Figueres, Lucile, Gaisne, Raphael, Garandeau, Claire, Giral, Magali, Gourraud-Vercel, Caroline, Hourmant, Maryvonne, Karam, Georges, Kerleau, Clarisse, Kervella, Delphine, Masset, Christophe, Meurette, Aurélie, Ville, Simon, Kandell, Christine, Moreau, Anne, Renaudin, Karine, Delbos, Florent, Walencik, Alexandre, Devis, Anne, Amrouche, Lucile, Anglicheau, Dany, Aubert, Olivier, Bererhi, Lynda, Legendre, Christophe, Loupy, Alexandre, Martinez, Frank, Méjean, Arnaud, Sberro-Soussan, Rébecca, Scemla, Anne, Timsit, Marc-Olivier, Zuber, Julien, Danger, Richard, Le Berre, Ludmilla, Cadoux, Marion, Papuchon, Emmanuelle, Mai, Hoa Le, Nguyen, Thi-Van-Ha, Guérif, Pierrick, Lefaucheur, Carmen, Couzi, Lionel, Del Bello, Arnaud, Kamar, Nassim, Le Quintrec, Moglie, Goutaudier, Valentin, and Brouard, Sophie

Published
2023
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27. Prognostic Biomarkers in Kidney Transplantation: A Systematic Review and Critical Appraisal

Author

Raynaud, Marc, Al-Awadhi, Solaf, Louis, Kevin, Zhang, Huanxi, Su, Xiaojun, Goutaudier, Valentin, Wang, Jiali, Demir, Zeynep, Wei, Yongcheng, Truchot, Agathe, Bouquegneau, Antoine, Del Bello, Arnaud, Bailly, Élodie, Lombardi, Yannis, Maanaoui, Mehdi, Giarraputo, Alessia, Naser, Sofia, Divard, Gillian, Aubert, Olivier, Murad, Mohammad Hassan, Wang, Changxi, Liu, Longshan, Bestard, Oriol, Naesens, Maarten, Friedewald, John J., Lefaucheur, Carmen, Riella, Leonardo, Collins, Gary, Ioannidis, John P.A., and Loupy, Alexandre

Published
2024
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29. Machine learning does not outperform traditional statistical modelling for kidney allograft failure prediction

Author

Truchot, Agathe, Raynaud, Marc, Kamar, Nassim, Naesens, Maarten, Legendre, Christophe, Delahousse, Michel, Thaunat, Olivier, Buchler, Matthias, Crespo, Marta, Linhares, Kamilla, Orandi, Babak J., Akalin, Enver, Pujol, Gervacio Soler, Silva, Helio Tedesco, Jr., Gupta, Gaurav, Segev, Dorry L., Jouven, Xavier, Bentall, Andrew J., Stegall, Mark D., Lefaucheur, Carmen, Aubert, Olivier, and Loupy, Alexandre

Published
2023
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31. Tacrolimus to belatacept conversion in proteinuric kidney transplant recipients.

Author

Efe, Orhan, Al Jurdi, Ayman, Eiting, Morgan Mabey, Marks, Christine Rogers, Cote, Mariesa Ann, Wojciechowski, David, Safa, Kassem, Gilligan, Hannah, Azzi, Jamil, Goyal, Nitender, Raynaud, Marc, Loupy, Alexandre, Weins, Astrid, and Riella, Leonardo V.

Subjects
GLOMERULAR filtration rate, CLINICAL trials, BELATACEPT, KIDNEY transplantation, GRAFT survival
Abstract

Background: Proteinuria is associated with worse allograft outcomes in kidney transplant recipients (KTRs) and treatment strategies are limited. We examined the outcomes of calcineurin inhibitor (CNI) to belatacept conversion in proteinuric KTRs. Methods: In a pilot phase II single-arm multicenter prospective trial, we recruited adult KTRs >6 months post-kidney transplantation with an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73m2 and proteinuria >1 g/day. Patients were converted from CNI to belatacept. The primary outcome was a 25% reduction in proteinuria at 12 months. Results: A total of 15 KTRs were recruited who had pre-conversion median (interquartile range) proteinuria of 1.8 (IQR 1.4 – 3.5) g/g and estimated glomerular filtration rate (eGFR) of 48 (IQR 32 – 52.5) ml/min/1.73m2. At 12 months post-conversion, median proteinuria was 1.4 (IQR 0.4 – 2.2) g/g (P = 0.068) and eGFR was maintained at 43 (34 – 54.5) ml/min/1.73m2. The primary outcome of at least a 25% reduction in proteinuria occurred in 53% (8/15) at 12 months. Abbreviated IBOX scores predicting 7-year graft survival were also stable at 1-year post-conversion compared to baseline. At extended follow-up at 5 years, both proteinuria and eGFR remained stable at 0.69 (0.24 – 2.15) g/g and 39 (31 – 57) ml/min/1.73m2, respectively. Conclusions: CNI to belatacept conversion was associated with preserved allograft function in KTRs with significant proteinuria. These findings need to be confirmed in a larger randomized clinical trial. Clinical trial registration: https://clinicaltrials.gov/ , identifier NCT0232740. [ABSTRACT FROM AUTHOR]

Published
2025
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32. Evaluation of a Decentralized Donor-Derived Cell-Free DNA Assay for Kidney Allograft Rejection Monitoring.

Author

Loupy, Alexandre, Certain, Anaïs, Tangprasertchai, Narin S., Racapé, Maud, Ursule-Dufait, Cindy, Benbadi, Kawthar, Raynaud, Marc, Vaskova, Evgeniya, Marchis, Corina, Casas, Sílvia, Hague, Tim, Bestard, Oriol, Kervella, Delphine, Lefaucheur, Carmen, Viard, Thierry, and Aubert, Olivier

Subjects
*GRAFT rejection, *CELL-free DNA, *LOGISTIC regression analysis, *KIDNEY transplantation, *RENAL biopsy
Abstract

Donor-derived cell-free DNA (dd-cfDNA) is an emerging non-invasive biomarker for allograft injury detection. This study aimed to evaluate a new, decentralized dd-cfDNA testing kit against a centralized dd-cfDNA testing service broadly utilized in the United States. Kidney transplant recipients with decentralized and centralized dd-cfDNA measurements and concomitant kidney allograft biopsies were included in the study. 580 kidney allograft recipients from 3 referral centers were included for 603 total evaluations. Correlation between assays was evaluated using r-squared (r 2) and Spearman's rank correlation test, and associations with rejection using logistic regression analyses and discrimination using area under the curve. Mean dd-cfDNA levels from decentralized and centralized tests were 0.51% ± 0.81% and 0.43% ± 0.78%, respectively. The assays were highly correlated, with r 2 = 0.95 and Spearman's rank correlation 0.88 (p < 0.0001). Both tests showed significant association with allograft rejection (p < 0.0001) and good and similar discriminations to predict rejection (AUC: 0.758 for the decentralized and AUC: 0.760 for the centralized dd-cfDNA; p = 0.8466). Consistency between the assays was also confirmed across clinical scenarios including post-transplant timepoint, allograft stability, and allograft rejection subcategories. This decentralized dd-cfDNA assessment demonstrates high accuracy and value to non-invasively monitor kidney recipients. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Safety, tolerability, and efficacy of monoclonal CD38 antibody felzartamab in late antibody-mediated renal allograft rejection: study protocol for a phase 2 trial

Author

Mayer, Katharina A., Budde, Klemens, Halloran, Philip F., Doberer, Konstantin, Rostaing, Lionel, Eskandary, Farsad, Christamentl, Anna, Wahrmann, Markus, Regele, Heinz, Schranz, Sabine, Ely, Sarah, Firbas, Christa, Schörgenhofer, Christian, Kainz, Alexander, Loupy, Alexandre, Härtle, Stefan, Boxhammer, Rainer, Jilma, Bernd, and Böhmig, Georg A.

Published
2022
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35. Comparison of artificial intelligence and human-based prediction and stratification of the risk of long-term kidney allograft failure

Author

Divard, Gillian, Raynaud, Marc, Tatapudi, Vasishta S., Abdalla, Basmah, Bailly, Elodie, Assayag, Maureen, Binois, Yannick, Cohen, Raphael, Zhang, Huanxi, Ulloa, Camillo, Linhares, Kamila, Tedesco, Helio S., Legendre, Christophe, Jouven, Xavier, Montgomery, Robert A., Lefaucheur, Carmen, Aubert, Olivier, and Loupy, Alexandre

Published
2022
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38. 240.1: The Risk of Venous Thromboembolism Is Enhanced After A Cytomegalovirus Infection in Kidney Transplant Recipient

Author

Masset, Christophe, Scemla, Anne, Kerleau, Clarisse, Bressolette, Celine, Le borgne, Florent, Morelon, Emmanuel, Buron, Fanny, Lequintrec-Donnette, Moglie, Perrin, Vincent, Ladrière, Marc, Girerd, Sophie, Legendre, Christophe, Loupy, Alexandre, Sicard, Antoine, Albano, Laetitia, Lefaucheur, Carmen, Glotz, Denis, Mariat, Christophe, Claisse, Guillaume, Dantal, Jacques, and Giral, Magali

Published
2022
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39. The impact of competing risks in kidney allograft failure prediction

Author

Truchot, Agathe, primary, Raynaud, Marc, additional, Helantera, Ilkka, additional, Aubert, Olivier, additional, Kamar, Nassim, additional, Legendre, Christophe, additional, Hertig, Alexandre, additional, Buchler, Matthias, additional, Crespo, Marta, additional, Akalin, Enver, additional, Soler Pujol, Gervasio, additional, Ribeiro de Castro, Maria Cristina, additional, Matas, Arthur J., additional, Ulloa, Camilo, additional, Jordan, Stanley C., additional, Huang, Edmund, additional, Juric, Ivana, additional, Basic-Jukic, Nikolina, additional, Coemans, Maarten, additional, Naesens, Maarten, additional, Friedewald, John J., additional, Tedesco Silva, Helio, additional, Lefaucheur, Carmen, additional, Segev, Dorry L., additional, Collins, Gary S., additional, and Loupy, Alexandre, additional

Published
2024
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41. The Banff 2022 Kidney Meeting Work Plan:Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, Mengel, Michael, Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, and Mengel, Michael

Abstract

The XVIth Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from September 19 to 23, 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular inflammation and biopsy-based transcript analysis on the Banff Classification, further sessions were devoted to other aspects of kidney transplant pathology, in particular T cell–mediated rejection, activity and chronicity indices, digital pathology, xenotransplantation, clinical trials, and surrogate endpoints. Although the output of these sessions has not led to any changes in the classification, the key role of Banff Working Groups in phrasing unanswered questions, and coordinating and disseminating results of investigations addressing these unanswered questions was emphasized. This paper summarizes the key Banff Meeting 2022 sessions not covered in the Banff Kidney Meeting 2022 Report paper and also provides an update on other Banff Working Group activities relevant to kidney allografts.

Published
2024

42. Prognostic Biomarkers in Kidney Transplantation: A Systematic Review and Critical Appraisal

Author

Raynaud, Marc, primary, Al-Awadhi, Solaf, additional, Louis, Kevin, additional, Zhang, Huanxi, additional, Su, Xiaojun, additional, Goutaudier, Valentin, additional, Wang, Jiali, additional, Demir, Zeynep, additional, Wei, Yongcheng, additional, Truchot, Agathe, additional, Bouquegneau, Antoine, additional, Del Bello, Arnaud, additional, Bailly, Élodie, additional, Lombardi, Yannis, additional, Maanaoui, Mehdi, additional, Giarraputo, Alessia, additional, Naser, Sofia, additional, Divard, Gillian, additional, Aubert, Olivier, additional, Murad, Mohammad Hassan, additional, Wang, Changxi, additional, Liu, Longshan, additional, Bestard, Oriol, additional, Naesens, Maarten, additional, Friedewald, John J., additional, Lefaucheur, Carmen, additional, Riella, Leonardo, additional, Collins, Gary, additional, Ioannidis, John P.A., additional, and Loupy, Alexandre, additional

Published
2023
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43. Identification of liver transplant biopsy phenotypes associated with distinct liver biological markers and allograft survival

Author

Demir, Zeynep, primary, Raynaud, Marc, additional, Aubert, Olivier, additional, Debray, Dominique, additional, Sebagh, Mylène, additional, Van Huyen, Jean-Paul Duong, additional, Del Bello, Arnaud, additional, Congy Jolivet, Nicolas, additional, Paradis, Valérie, additional, Durand, François, additional, Muratot, Sophie, additional, Lozach, Cécile, additional, Chardot, Christophe, additional, Francoz, Claire, additional, Sarnacki, Sabine, additional, Coilly, Audrey, additional, Samuel, Didier, additional, Vibert, Eric, additional, Féray, Cyrille, additional, Lefaucheur, Carmen, additional, and Loupy, Alexandre, additional

Published
2023
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44. Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Josephson, Michelle A., primary, Becker, Yolanda, additional, Budde, Klemens, additional, Kasiske, Bertram L., additional, Kiberd, Bryce A., additional, Loupy, Alexandre, additional, Małyszko, Jolanta, additional, Mannon, Roslyn B., additional, Tönshoff, Burkhard, additional, Cheung, Michael, additional, Jadoul, Michel, additional, Winkelmayer, Wolfgang C., additional, Zeier, Martin, additional, Ahn, Curie, additional, Alberú, Josefina, additional, Baliker, Mary, additional, Bamgboye, Ebun L., additional, Barber, Thelma, additional, Bensouda, Melissa, additional, Chadban, Steve J., additional, Dadhania, Darshana M., additional, Dębska-Ślizień, Alicja, additional, Devresse, Arnaud, additional, Ditzen, Beate, additional, Fowler, Kevin, additional, Gill, John S., additional, Jha, Vivekanand, additional, Khairallah, Pascale, additional, Knoll, Greg A., additional, Korst, Uwe, additional, Lee, Austin, additional, Legendre, Christophe, additional, Lentine, Krista L., additional, Lerma, Edgar V., additional, Lorenz, Elizabeth C., additional, Matas, Arthur J., additional, Mohan, Sumit, additional, Nazarewski, Sławomir, additional, Noronha, Irene L., additional, Obrador, Gregorio T., additional, Parekh, Rulan S., additional, Pavlakis, Martha, additional, Pascual, Julio, additional, Pilmore, Helen L., additional, Rosenkranz, Alexander R., additional, Rozen-Zvi, Benaya, additional, Roy-Chaudhury, Prabir, additional, Tanabe, Kazunari, additional, Wanner, Christoph, additional, Wasse, Haimanot, additional, and Yang, Chul-Woo, additional

Published
2023
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46. The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, primary, Naesens, Maarten, additional, Haas, Mark, additional, Lefaucheur, Carmen, additional, Mannon, Roslyn B., additional, Afrouzian, Marjan, additional, Alachkar, Nada, additional, Aubert, Olivier, additional, Bagnasco, Serena M., additional, Batal, Ibrahim, additional, Bellamy, Chris O.C., additional, Broecker, Verena, additional, Budde, Klemens, additional, Clahsen-Van Groningen, Marian, additional, Coley, Shana M., additional, Cornell, Lynn D., additional, Dadhania, Darshana, additional, Demetris, Anthony J., additional, Einecke, Gunilla, additional, Farris, Alton B., additional, Fogo, Agnes B., additional, Friedewald, John, additional, Gibson, Ian W., additional, Horsfield, Catherine, additional, Huang, Edmund, additional, Husain, Syed A., additional, Jackson, Annette M., additional, Kers, Jesper, additional, Kikić, Željko, additional, Klein, Amanda, additional, Kozakowski, Nicolas, additional, Liapis, Helen, additional, Mangiola, Massima, additional, Montgomery, Robert A., additional, Nankinvell, Brian, additional, Neil, Desley A.H., additional, Nickerson, Peter, additional, Rabant, Marion, additional, Randhawa, Parmjeet, additional, Riella, Leonardo V., additional, Rosales, Ivy, additional, Royal, Virginie, additional, Sapir-Pichhadze, Ruth, additional, Sarder, Pinaki, additional, Sarwal, Minnie, additional, Schinstock, Carrie, additional, Stegall, Mark, additional, Solez, Kim, additional, van der Laak, Jeroen, additional, Wiebe, Chris, additional, Colvin, Robert B., additional, Loupy, Alexandre, additional, and Mengel, Michael, additional

Published
2023
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48. Banff Digital Pathology Working Group: Image Bank, Artificial Intelligence Algorithm, and Challenge Trial Developments

Author

Farris, Alton B., primary, Alexander, Mariam P., additional, Balis, Ulysses G. J., additional, Barisoni, Laura, additional, Boor, Peter, additional, Bülow, Roman D., additional, Cornell, Lynn D., additional, Demetris, Anthony J., additional, Farkash, Evan, additional, Hermsen, Meyke, additional, Hogan, Julien, additional, Kain, Renate, additional, Kers, Jesper, additional, Kong, Jun, additional, Levenson, Richard M., additional, Loupy, Alexandre, additional, Naesens, Maarten, additional, Sarder, Pinaki, additional, Tomaszewski, John E., additional, van der Laak, Jeroen, additional, van Midden, Dominique, additional, Yagi, Yukako, additional, and Solez, Kim, additional

Published
2023
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50. Report of the 2022 Banff Heart Concurrent: Focus on Non-HLA Antibodies in Rejection and the Pathology of “Mixed” Rejection

Author

Fedrigo, Marny, primary, Berry, Gerald J., additional, Coutance, Guillaume, additional, Reed, Elaine F., additional, Lin, Chieh-Yu, additional, Giarraputo, Alessia, additional, Kransdorf, Evan, additional, Thaunat, Olivier, additional, Goddard, Martin, additional, Angelini, Annalisa, additional, Neil, Desley AH., additional, Bruneval, Patrick, additional, Duong Van Huyen, Jean-Paul, additional, Loupy, Alexandre, additional, and Miller, Dylan V., additional

Published
2023
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