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Your search keyword '"Lopez, Angel"' showing total 231 results
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231 results on '"Lopez, Angel"'

1. Designing an adaptive room for captivating the collective consciousness from internal states

Author

Flores-Ramírez, Adán, Alarcón-López, Ángel Mario, Vaca-Narvaja, Sofía, and Leo-Orozco, Daniela

Subjects
Computer Science - Neural and Evolutionary Computing, Quantitative Biology - Neurons and Cognition
Abstract

Beyond conventional productivity metrics, human interaction and collaboration dynamics merit careful consideration in our increasingly digital workspace. This research proposes a conjectural neuro-adaptive room that enhances group interactions by adjusting the physical environment to desired internal states. Drawing inspiration from previous work on collective consciousness, the system leverages computer vision and machine learning models to analyze physiological and behavioral cues, such as facial expressions and speech analysis, to infer the overall internal state of occupants. Environmental conditions of the room, such as visual projections, lighting and sound, are actively adjusted to create an optimal setting for inducing the desired state, including focus or collaboration. Our goal is to create a dynamic and responsive environment to support group needs, fostering a sense of collective consciousness and improving workplace well-being., Comment: 5 pages, 2 figures. Longevity, AI, and Cognitive Research Hackathon

Published
2024

2. Dynamical Mean-Field Theory of Self-Attention Neural Networks

Author

Poc-López, Ángel and Aguilera, Miguel

Subjects
Condensed Matter - Disordered Systems and Neural Networks, Computer Science - Machine Learning
Abstract

Transformer-based models have demonstrated exceptional performance across diverse domains, becoming the state-of-the-art solution for addressing sequential machine learning problems. Even though we have a general understanding of the fundamental components in the transformer architecture, little is known about how they operate or what are their expected dynamics. Recently, there has been an increasing interest in exploring the relationship between attention mechanisms and Hopfield networks, promising to shed light on the statistical physics of transformer networks. However, to date, the dynamical regimes of transformer-like models have not been studied in depth. In this paper, we address this gap by using methods for the study of asymmetric Hopfield networks in nonequilibrium regimes --namely path integral methods over generating functionals, yielding dynamics governed by concurrent mean-field variables. Assuming 1-bit tokens and weights, we derive analytical approximations for the behavior of large self-attention neural networks coupled to a softmax output, which become exact in the large limit size. Our findings reveal nontrivial dynamical phenomena, including nonequilibrium phase transitions associated with chaotic bifurcations, even for very simple configurations with a few encoded features and a very short context window. Finally, we discuss the potential of our analytic approach to improve our understanding of the inner workings of transformer models, potentially reducing computational training costs and enhancing model interpretability.

Published
2024

3. Magnetic versus nonmagnetic polymorphs of RuBr$_3$ under pressure

Author

Shen, Bin, Ginga, Victoria A., Arévalo-López, Angel M., Garbarino, Gaston, Uykur, Ece, Goncalves-Faria, Marcos, Mukharjee, Prashanta K., Gegenwart, Philipp, and Tsirlin, Alexander A.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

Pressure evolution of the crystal structure and magnetism of the honeycomb $\alpha$-RuBr$_3$ is studied using high-pressure x-ray diffraction, magnetometry, and density-functional band-structure calculations. Hydrostatic compression transforms antiferromagnetic $\alpha$-RuBr$_3$ ($R\bar 3$) into paramagnetic $\alpha'$-RuBr$_3$ ($P\bar 1$) where short Ru-Ru bonds cause magnetism collapse above 1.3 GPa at 0 K and 2.5 GPa at 295 K. Below this critical pressure, the N\'eel temperature of $\alpha$-RuBr$_3$ increases with the slope of 1.8 K/GPa. Pressure tunes $\alpha$-RuBr$_3$ away from the Kitaev limit, whereas increased third-neighbor in-plane coupling and interlayer coupling lead to a further stabilization of the collinear zigzag state. Both $\alpha$- and $\alpha'$-RuBr$_3$ are metastable at ambient pressure, but their transformation into the thermodynamically stable $\beta$-polymorph is kinetically hindered at room temperature., Comment: 8 pages + Supplemental Material: published version

Published
2024
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4. Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s.

Author

Roy, Pritam, Maturano, Jonathan, Hasdemir, Hale, Lopez, Angel, Xu, Fengyun, Tajkhorshid, Emad, Sarlah, David, Das, Aditi, and Hellman, Judith

Subjects
Humans, Cytochrome P-450 Enzyme System, Mice, Animals, Cannabinoids, Molecular Structure, Molecular Dynamics Simulation, Male, Cytochrome P-450 CYP2C9
Abstract

Cannabichromene (CBC) is a nonpsychoactive phytocannabinoid well-known for its wide-ranging health advantages. However, there is limited knowledge regarding its human metabolism following CBC consumption. This research aimed to explore the metabolic pathways of CBC by various human liver cytochrome P450 (CYP) enzymes and support the outcomes using in vivo data from mice. The results unveiled two principal CBC metabolites generated by CYPs: 8-hydroxy-CBC and 6,7-epoxy-CBC, along with a minor quantity of 1″-hydroxy-CBC. Notably, among the examined CYPs, CYP2C9 demonstrated the highest efficiency in producing these metabolites. Moreover, through a molecular dynamics simulation spanning 1 μs, it was observed that CBC attains stability at the active site of CYP2J2 by forming hydrogen bonds with I487 and N379, facilitated by water molecules, which specifically promotes the hydroxy metabolites formation. Additionally, the presence of cytochrome P450 reductase (CPR) amplified CBCs binding affinity to CYPs, particularly with CYP2C8 and CYP3A4. Furthermore, the metabolites derived from CBC reduced cytokine levels, such as IL6 and NO, by approximately 50% in microglia cells. This investigation offers valuable insights into the biotransformation of CBC, underscoring the physiological importance and the potential significance of these metabolites.

Published
2024

5. Towards a Zero-Defect in Welding: An Exploration of Factors to Improve the Training Data for Image Classification

Author

Javanbakhtghahfarokhi, Negin, Lopez, Angel J., Rodríguez-Echeverría, Jorge, Gautama, Sidharta, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Arai, Kohei, editor

Published
2024
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6. Opportunities and Challenges in Inquiry-Based Science Education

Author

Moraga-Toledo, Sylvia, García-Ruiz, Cristina, Lupión-Cobos, Teresa, Blanco-López, Ángel, Zeidler, Dana L., Series Editor, Bencze, John Lawrence, Editorial Board Member, Clough, Michael P., Editorial Board Member, Abd-El-Khalick, Fouad, Editorial Board Member, Rollnick, Marissa, Editorial Board Member, Sadler, Troy D., Editorial Board Member, Sjøeberg, Svein, Editorial Board Member, Treagust, David, Editorial Board Member, Yore, Larry D, Editorial Board Member, Marzabal, Ainoa, editor, and Merino, Cristian, editor

Published
2024
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7. A Viability Study of Pickup and Delivery Locations Using Genetic Algorithm in Intelligent Transportation Systems

Author

Lucq, Delphine, Lopez, Angel J., Aghezzaf, El-Houssaine, Semanjski, Ivana, Gautama, Sidharta, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Arai, Kohei, editor

Published
2024
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8. Part-of-Speech Tagging Accuracy for Manufacturing Process Documents and Knowledge

Author

Moghaddam, Fatemeh Besharati, Lopez, Angel J., De Vuyst, Stijn, Gautama, Sidharta, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Arai, Kohei, editor

Published
2024
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9. Knitting a Markov blanket is hard when you are out-of-equilibrium: two examples in canonical nonequilibrium models

Author

Aguilera, Miguel, Poc-López, Ángel, Heins, Conor, and Buckley, Christopher L.

Subjects
Quantitative Biology - Neurons and Cognition, Condensed Matter - Disordered Systems and Neural Networks, Nonlinear Sciences - Chaotic Dynamics
Abstract

Bayesian theories of biological and brain function speculate that Markov blankets (a conditional independence separating a system from external states) play a key role for facilitating inference-like behaviour in living systems. Although it has been suggested that Markov blankets are commonplace in sparsely connected, nonequilibrium complex systems, this has not been studied in detail. Here, we show in two different examples (a pair of coupled Lorenz systems and a nonequilibrium Ising model) that sparse connectivity does not guarantee Markov blankets in the steady-state density of nonequilibrium systems. Conversely, in the nonequilibrium Ising model explored, the more distant from equilibrium the system appears to be correlated with the distance from displaying a Markov blanket. These result suggests that further assumptions might be needed in order to assume the presence of Markov blankets in the kind of nonequilibrium processes describing the activity of living systems.

Published
2022

21. Knitting a Markov Blanket is Hard When You are Out-of-Equilibrium: Two Examples in Canonical Nonequilibrium Models

Author

Aguilera, Miguel, Poc-López, Ángel, Heins, Conor, Buckley, Christopher L., Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Buckley, Christopher L., editor, Cialfi, Daniela, editor, Lanillos, Pablo, editor, Ramstead, Maxwell, editor, Sajid, Noor, editor, Shimazaki, Hideaki, editor, and Verbelen, Tim, editor

Published
2023
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22. A Toyota Corolla Hybrid GUI Based on Simulink and LabVIEW for Live-Data Acquisition and Monitoring System

Author

López, Ángel, Rojas, Diego, Fernández, Efrén, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Robles-Bykbaev, Vladimir, editor, Mula, Josefa, editor, and Reynoso-Meza, Gilberto, editor

Published
2023
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30. Cytokine Receptors and Their Ligands

Author

Shing, Karen S.C.T., primary, Kan, Winnie L., additional, Nero, Tracy L., additional, Hercus, Timothy R., additional, Tvorogov, Denis, additional, Metcalfe, Riley D., additional, Griffin, Michael D.W., additional, De Weerd, Nicole A., additional, Guthridge, Mark A., additional, Hertzog, Paul J., additional, Lopez, Angel F., additional, and Parker, Michael W., additional

Published
2023
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38. TLR7 gain-of-function genetic variation causes human lupus

Author

Brown, Grant J., Cañete, Pablo F., Wang, Hao, Medhavy, Arti, Bones, Josiah, Roco, Jonathan A., He, Yuke, Qin, Yuting, Cappello, Jean, Ellyard, Julia I., Bassett, Katharine, Shen, Qian, Burgio, Gaetan, Zhang, Yaoyuan, Turnbull, Cynthia, Meng, Xiangpeng, Wu, Phil, Cho, Eun, Miosge, Lisa A., Andrews, T. Daniel, Field, Matt A., Tvorogov, Denis, Lopez, Angel F., Babon, Jeffrey J., López, Cristina Aparicio, Gónzalez-Murillo, África, Garulo, Daniel Clemente, Pascual, Virginia, Levy, Tess, Mallack, Eric J., Calame, Daniel G., Lotze, Timothy, Lupski, James R., Ding, Huihua, Ullah, Tomalika R., Walters, Giles D., Koina, Mark E., Cook, Matthew C., Shen, Nan, de Lucas Collantes, Carmen, Corry, Ben, Gantier, Michael P., Athanasopoulos, Vicki, and Vinuesa, Carola G.

Published
2022
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39. Targeting the Human βc Receptor Inhibits Contact Dermatitis in a Transgenic Mouse Model

Author

Yip, Kwok Ho, McKenzie, Duncan, Ramshaw, Hayley S., Chao, Jessica, McClure, Barbara J., Raquet, Elmar, Kraushaar, Timo, Röder, Joachim, Maxwell, Mhairi, Alhamdoosh, Monther, Hammet, Andrew, Fong, Jia Hong, Zeglinski, Kathleen, Monaghan, Katherine, Pant, Harshita, Grimbaldeston, Michele A., Vairo, Gino, Wilson, Nicholas J., Owczarek, Catherine M., Hercus, Timothy R., Lopez, Angel F., and Tumes, Damon J.

Published
2022
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41. Personalized bacteriophage therapy outcomes for 100 consecutive cases:a multicentre, multinational, retrospective observational study

Author

Pirnay, Jean Paul, Djebara, Sarah, Steurs, Griet, Griselain, Johann, Cochez, Christel, De Soir, Steven, Glonti, Tea, Spiessens, An, Vanden Berghe, Emily, Green, Sabrina, Wagemans, Jeroen, Lood, Cédric, Schrevens, Eddie, Chanishvili, Nina, Kutateladze, Mzia, de Jode, Mathieu, Ceyssens, Pieter Jan, Draye, Jean Pierre, Verbeken, Gilbert, De Vos, Daniel, Rose, Thomas, Onsea, Jolien, Van Nieuwenhuyse, Brieuc, Soentjens, Patrick, Lavigne, Rob, Merabishvili, Maya, Pang, Kim Win, Metsemakers, Willem Jan, Van der Linden, Dimitri, Chatzis, Olga, Eskenazi, Anaïs, Lopez, Angel, De Voeght, Adrien, Rousseau, Anne Françoise, Tilmanne, Anne, Vens, Daphne, Gérain, Jean, Layeux, Brice, Vlieghe, Erika, Baar, Ingrid, Van Ierssel, Sabrina, Van Laethem, Johan, Guiot, Julien, De Roock, Sophie, Jennes, Serge, Uyttebroek, Saartje, Van Gerven, Laura, Hellings, Peter W., Dupont, Lieven, Debaveye, Yves, Devolder, David, Spriet, Isabel, De Munter, Paul, Depypere, Melissa, Vanfleteren, Michiel, Cornu, Olivier, Verhulst, Stijn, Boiy, Tine, Lamote, Stoffel, Van Zele, Thibaut, Wieërs, Grégoire, Courtin, Cécile, Lebeaux, David, Sartre, Jacques, Ferry, Tristan, Laurent, Frédéric, Paul, Kevin, Di Luca, Mariagrazia, Gottschlich, Stefan, Tkhilaishvili, Tamta, Cesta, Novella, Racenis, Karlis, Barbosa, Telma, López-Cortés, Luis Eduardo, Tomás, Maria, Hübner, Martin, Pham, Truong Thanh, Nagtegaal, Paul, Ten Oever, Jaap, Daniels, Johannes, Loubert, Maartje, Iheb, Ghariani, Jones, Joshua, Hall, Lesley, Young, Matthew, Balarjishvili, Nana, Tediashvili, Marina, Tong, Yigang, Rohde, Christine, Wittmann, Johannes, Hazan, Ronen, Nir-Paz, Ran, Azeredo, Joana, Krylov, Victor, Cameron, David, Pitton, Melissa, Que, Yok Ai, Resch, Gregory, McCallin, Shawna, Dunne, Matthew, Kilcher, Samuel, Pirnay, Jean Paul, Djebara, Sarah, Steurs, Griet, Griselain, Johann, Cochez, Christel, De Soir, Steven, Glonti, Tea, Spiessens, An, Vanden Berghe, Emily, Green, Sabrina, Wagemans, Jeroen, Lood, Cédric, Schrevens, Eddie, Chanishvili, Nina, Kutateladze, Mzia, de Jode, Mathieu, Ceyssens, Pieter Jan, Draye, Jean Pierre, Verbeken, Gilbert, De Vos, Daniel, Rose, Thomas, Onsea, Jolien, Van Nieuwenhuyse, Brieuc, Soentjens, Patrick, Lavigne, Rob, Merabishvili, Maya, Pang, Kim Win, Metsemakers, Willem Jan, Van der Linden, Dimitri, Chatzis, Olga, Eskenazi, Anaïs, Lopez, Angel, De Voeght, Adrien, Rousseau, Anne Françoise, Tilmanne, Anne, Vens, Daphne, Gérain, Jean, Layeux, Brice, Vlieghe, Erika, Baar, Ingrid, Van Ierssel, Sabrina, Van Laethem, Johan, Guiot, Julien, De Roock, Sophie, Jennes, Serge, Uyttebroek, Saartje, Van Gerven, Laura, Hellings, Peter W., Dupont, Lieven, Debaveye, Yves, Devolder, David, Spriet, Isabel, De Munter, Paul, Depypere, Melissa, Vanfleteren, Michiel, Cornu, Olivier, Verhulst, Stijn, Boiy, Tine, Lamote, Stoffel, Van Zele, Thibaut, Wieërs, Grégoire, Courtin, Cécile, Lebeaux, David, Sartre, Jacques, Ferry, Tristan, Laurent, Frédéric, Paul, Kevin, Di Luca, Mariagrazia, Gottschlich, Stefan, Tkhilaishvili, Tamta, Cesta, Novella, Racenis, Karlis, Barbosa, Telma, López-Cortés, Luis Eduardo, Tomás, Maria, Hübner, Martin, Pham, Truong Thanh, Nagtegaal, Paul, Ten Oever, Jaap, Daniels, Johannes, Loubert, Maartje, Iheb, Ghariani, Jones, Joshua, Hall, Lesley, Young, Matthew, Balarjishvili, Nana, Tediashvili, Marina, Tong, Yigang, Rohde, Christine, Wittmann, Johannes, Hazan, Ronen, Nir-Paz, Ran, Azeredo, Joana, Krylov, Victor, Cameron, David, Pitton, Melissa, Que, Yok Ai, Resch, Gregory, McCallin, Shawna, Dunne, Matthew, and Kilcher, Samuel

Abstract

In contrast to the many reports of successful real-world cases of personalized bacteriophage therapy (BT), randomized controlled trials of non-personalized bacteriophage products have not produced the expected results. Here we present the outcomes of a retrospective observational analysis of the first 100 consecutive cases of personalized BT of difficult-to-treat infections facilitated by a Belgian consortium in 35 hospitals, 29 cities and 12 countries during the period from 1 January 2008 to 30 April 2022. We assessed how often personalized BT produced a positive clinical outcome (general efficacy) and performed a regression analysis to identify functional relationships. The most common indications were lower respiratory tract, skin and soft tissue, and bone infections, and involved combinations of 26 bacteriophages and 6 defined bacteriophage cocktails, individually selected and sometimes pre-adapted to target the causative bacterial pathogens. Clinical improvement and eradication of the targeted bacteria were reported for 77.2% and 61.3% of infections, respectively. In our dataset of 100 cases, eradication was 70% less probable when no concomitant antibiotics were used (odds ratio = 0.3; 95% confidence interval = 0.127–0.749). In vivo selection of bacteriophage resistance and in vitro bacteriophage–antibiotic synergy were documented in 43.8% (7/16 patients) and 90% (9/10) of evaluated patients, respectively. We observed a combination of antibiotic re-sensitization and reduced virulence in bacteriophage-resistant bacterial isolates that emerged during BT. Bacteriophage immune neutralization was observed in 38.5% (5/13) of screened patients. Fifteen adverse events were reported, including seven non-serious adverse drug reactions suspected to be linked to BT. While our analysis is limited by the uncontrolled nature of these data, it indicates that BT can be effective in combination with antibiotics and can inform the design of future controlled clinical trials. B

Published
2024

42. CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting.

Author

Lim, Kelly, Kan, Winnie L., Nair, Pramod C., Kutyna, Monika, Lopez, Angel F., Hercus, Timothy, Ross, David M., Lane, Steven, Fong, Chun Yew, Brown, Anna, Yong, Agnes, Yeung, David, Hughes, Timothy, Hiwase, Devendra, and Thomas, Daniel

Subjects
CHRONIC leukemia, PROGENITOR cells, OLDER people, STEM cells, CANCER patients
Abstract

Chronic myelomonocytic leukemia (CMML) is a rare blood cancer of older adults (3 in every 1,000,000 persons) characterized by poor survival and lacking effective mutation-specific therapy. Mutations in the ubiquitin ligase Cbl occur frequently in CMML and share biological and molecular features with a clonal disease occurring in children, juvenile myelomonocytic leukemia (JMML). Here we analyzed the clinical presentations, molecular features and immunophenotype of CMML patients with CBL mutations enrolled in a prospective Phase II clinical trial stratified according to molecular markers. Clinically, CBL mutations were associated with increased bone marrow blasts at diagnosis, leukocytosis and splenomegaly, similar to patients harboring NRAS or KRAS mutations. Interestingly, 64% of patients presented with more than one CBL variant implying a complex subclonal architecture, often with co-occurrence of TET2 mutations. We found CBL mutations in CMML frequently clustered in the RING domain in contrast to JMML, where mutations frequently involve the linker helix region (P<0.0001). According to our comparative alignment of available X-ray structures, mutations in the linker helix region such as Y371E give rise to conformational differences that could be exploited by targeted therapy approaches. Furthermore, we noted an increased percentage of CMML CD34+ stem and progenitor cells expressing CD116 and CD131 in all CBL mutant cases and increased CD116 receptor density compared to healthy controls, similar to CMML overall. In summary, our data demonstrate that CBL mutations are associated with distinct molecular and clinical features in CMML and are potentially targetable with CD116-directed immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis

Author

Thompson, Emma J., primary, Escarbe, Samantha, additional, Tvorogov, Denis, additional, Farshid, Gelareh, additional, Gregory, Philip A., additional, Khew-Goodall, Yeesim, additional, Madden, Stephen, additional, Ingman, Wendy V., additional, Lindeman, Geoffrey J., additional, Lim, Elgene, additional, Lopez, Angel F., additional, and Bonder, Claudine S., additional

Published
2024
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47. Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Author

El Khawanky, Nadia, Hughes, Amy, Yu, Wenbo, Myburgh, Renier, Matschulla, Tony, Taromi, Sanaz, Aumann, Konrad, Clarson, Jade, Vinnakota, Janaki Manoja, Shoumariyeh, Khalid, Miething, Cornelius, Lopez, Angel F., Brown, Michael P., Duyster, Justus, Hein, Lutz, Manz, Markus G., Hughes, Timothy P., White, Deborah L., Yong, Agnes S. M., and Zeiser, Robert

Published
2021
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48. Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade

Author

Wang, Hao, primary, Yip, Kwok Ho, additional, Keam, Simon P., additional, Vlahos, Ross, additional, Nichol, Kristy, additional, Wark, Peter, additional, Toubia, John, additional, Kral, Anita C., additional, Cildir, Gökhan, additional, Pant, Harshita, additional, Hercus, Timothy R., additional, Wilson, Nick, additional, Owczarek, Catherine, additional, Lopez, Angel F., additional, Bozinovski, Steven, additional, and Tumes, Damon J., additional

Published
2023
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