38 results on '"Longoni, Marco"'
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2. Predictors of futile recanalization in nonagenarians treated with mechanical thrombectomy: a multi-center observational study
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D’Anna, Lucio, Merlino, Giovanni, Romoli, Michele, Zhang, Liqun, Del Regno, Caterina, Aggour, Mohammed, Levee, Viva, Foschi, Matteo, Sponza, Massimo, Toraldo, Francesco, Algazlan, Razan, Ruggiero, Maria, Longoni, Marco, Lobotesis, Kyriakos, Abu-Rumeileh, Samir, Bagatto, Daniele, Mansoor, Nina, Gigli, Gian Luigi, Valente, Mariarosaria, and Banerjee, Soma
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- 2024
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3. Thrombectomy in ischemic stroke patients with tandem occlusion in the posterior versus anterior circulation
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Cappellari, Manuel, Pracucci, Giovanni, Saia, Valentina, Mandruzzato, Nicolò, Valletta, Francesco, Sallustio, Fabrizio, Casetta, Ilaria, Fainardi, Enrico, Da Ros, Valerio, Diomedi, Marina, Capasso, Francesco, Nencini, Patrizia, Vallone, Stefano, Bigliardi, Guido, Tessitore, Agostino, La Spina, Paolino, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Ruggiero, Maria, Longoni, Marco, Castellan, Lucio, Malfatto, Laura, Saletti, Andrea, De Vito, Alessandro, Menozzi, Roberto, Scoditti, Umberto, Simonetti, Luigi, Zini, Andrea, Lafe, Elvis, Cavallini, Anna, Lazzarotti, Guido Andrea, Giannini, Nicola, Boghi, Andrea, Naldi, Andrea, Romano, Daniele, Napoletano, Rosa, Comai, Alessio, Franchini, Enrica, Cavasin, Nicola, Critelli, Adriana, Giorgianni, Andrea, Cariddi, Lucia Princiotta, Semeraro, Vittorio, Boero, Giovanni, Zimatore, Domenico Sergio, Petruzzellis, Marco, Biraschi, Francesco, Nicolini, Ettore, Pedicelli, Alessandro, Frisullo, Giovanni, Calzoni, Andrea, Tassinari, Tiziana, Gallesio, Ivan, Sepe, Federica, Filauri, Pietro, Sacco, Simona, Lozupone, Emilio, Rizzo, Annalisa, Besana, Michele, Giossi, Alessia, Pavia, Marco, Invernizzi, Paolo, Amistà, Pietro, Russo, Monia, Florio, Francesco, Inchingolo, Vincenzo, Filizzolo, Marco, Mannino, Marina, Mangiafico, Salvatore, and Toni, Danilo
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- 2024
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4. IV thrombolysis plus thrombectomy versus IV thrombolysis alone for minor stroke with anterior circulation large vessel occlusion from the IRETAS and Italian SITS-ISTR cohorts
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Cappellari, Manuel, Pracucci, Giovanni, Saia, Valentina, Fainardi, Enrico, Casetta, Ilaria, Sallustio, Fabrizio, Ruggiero, Maria, Longoni, Marco, Simonetti, Luigi, Zini, Andrea, Lazzarotti, Guido Andrea, Giannini, Nicola, Da Ros, Valerio, Diomedi, Marina, Vallone, Stefano, Bigliardi, Guido, Limbucci, Nicola, Nencini, Patrizia, Ajello, Daniele, Marcheselli, Simona, Burdi, Nicola, Boero, Giovanni, Bracco, Sandra, Tassi, Rossana, Boghi, Andrea, Naldi, Andrea, Biraschi, Francesco, Nicolini, Ettore, Castellan, Lucio, Del Sette, Massimo, Allegretti, Luca, Sugo, Annalisa, Buonomo, Orazio, Dell’Aera, Cristina, Saletti, Andrea, De Vito, Alessandro, Lafe, Elvis, Mazzacane, Federico, Bergui, Mauro, Cerrato, Paolo, Feraco, Paola, Piffer, Silvio, Augelli, Raffaele, Vit, Federica, Gasparotti, Roberto, Magoni, Mauro, Comelli, Simone, Melis, Maurizio, Menozzi, Roberto, Scoditti, Umberto, Cavasin, Nicola, Critelli, Adriana, Causin, Francesco, Baracchini, Claudio, Guzzardi, Giuseppe, Tarletti, Roberto, Filauri, Pietro, Orlandi, Berardino, Giorgianni, Andrea, Cariddi, Lucia Princiotta, Piano, Mariangela, Motto, Cristina, Gallesio, Ivan, Sepe, Federica Nicoletta, Romano, Giuseppe, Grasso, Maria Federico, Pauciulo, Alfredo, Rizzo, Annalisa, Comai, Alessio, Franchini, Enrica, Sicurella, Luigi, Galvano, Gianluca, Mannino, Marina, Mangiafico, Salvatore, Toni, Danilo, and on behalf of the IRETAS group
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- 2023
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5. Mechanical thrombectomy in patients with heart failure: the Italian registry of Endovascular Treatment in Acute Stroke
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Gentile, Luana, Pracucci, Giovanni, Saia, Valentina, Falcou, Anne, Biraschi, Francesco, Zini, Andrea, Simonetti, Luigi, Riva, Letizia, Bigliardi, Guido, Vallone, Stefano, Nencini, Patrizia, Limbucci, Nicola, Diomedi, Marina, Da Ros, Valerio, Longoni, Marco, Ruggiero, Maria, Tassinari, Tiziana, Allegretti, Luca, Cerrato, Paolo, Rubino, Elisa, Bergui, Mauro, Cavallo, Roberto, Naldi, Andrea, Comelli, Chiara, Cappellari, Manuel, Zivelonghi, Cecilia, Plebani, Mauro, De Vito, Alessandro, Merli, Nicola, Saletti, Andrea, Musolino, Rosa Fortunata, Ferraù, Ludovica, Vinci, Sergio Lucio, Sacco, Simona, Orlandi, Berardino, De Santis, Federica, Filauri, Pietro, Ruiz, Luigi, Sepe, Federica Nicoletta, Gallesio, Ivan, Petruzzellis, Marco, Chiumarulo, Luigi, Sangalli, Davide, Salmaggi, Andrea, Filizzolo, Marco, Moller, Jessica, Melis, Maurizio, Comelli, Simone, Magoni, Mauro, Gilberti, Nicola, Gasparotti, Roberto, Invernizzi, Paolo, Pavia, Marco, Pinto, Vincenza, Laspada, Salvatore, Marcheselli, Simona, Ajello, Daniele, Viaro, Federica, Baracchini, Claudio, Causin, Francesco, Giannini, Nicola, Caselli, Maria Chiara, Mancuso, Michelangelo, Cosottini, Mirco, Scoditti, Umberto, Menozzi, Roberto, Russo, Monia, Amistá, Pietro, Napoletano, Rosa, Romano, Daniele Giuseppe, Tassi, Rossana, Bracco, Sandra, Carimati, Federico, Versino, Maurizio, Giorgianni, Andrea, De Boni, Antonella, Fasano, Antonio, Barbarini, Leonardo, Paladini, Adriana, Franchini, Enrica, Dall’Ora, Elisa, Comai, Alessio, Giovanni, Frisullo, Pedicelli, Alessandro, Sallustio, Fabrizio, Casetta, Ilaria, Fainardi, Enrico, Mangiafico, Salvatore, and Toni, Danilo
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- 2023
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6. Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study
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Yaghi, Shadi, Shu, Liqi, Mandel, Daniel, Leon Guerrero, Christopher R., Henninger, Nils, Muppa, Jayachandra, Affan, Muhammad, Ul Haq Lodhi, Omair, Heldner, Mirjam R., Antonenko, Kateryna, Seiffge, David, Arnold, Marcel, Salehi Omran, Setareh, Crandall, Ross, Lester, Evan, Lopez Mena, Diego, Arauz, Antonio, Nehme, Ahmad, Boulanger, Marion, Touze, Emmanuel, Sousa, Joao Andre, Sargento-Freitas, Joao, Barata, Vasco, Castro-Chaves, Paulo, Brito, Maria Teresa, Khan, Muhib, Mallick, Dania, Rothstein, Aaron, Khazaal, Ossama, Kaufmann, Josefin E., Engelter, Stefan T., Traenka, Christopher, Aguiar de Sousa, Diana, Soares, Mafalda, Rosa, Sara, Zhou, Lily W., Gandhi, Preet, Field, Thalia S., Mancini, Steven, Metanis, Issa, Leker, Ronen R., Pan, Kelly, Dantu, Vishnu, Baumgartner, Karl, Burton, Tina, Von Rennenberg, Regina, Nolte, Christian H., Choi, Richard, MacDonald, Jason, Bavarsad Shahripour, Reza, Guo, Xiaofan, Ghannam, Malik, Almajali, Mohammad, Samaniego, Edgar A., Sanchez, Sebastian, Rioux, Bastien, Zine-Eddine, Faycal, Poppe, Alexandre, Fonseca, Ana Catarina, Baptista, Maria Fortuna, Cruz, Diana, Romoli, Michele, De Marco, Giovanna, Longoni, Marco, Keser, Zafer, Griffin, Kim, Kuohn, Lindsey, Frontera, Jennifer, Amar, Jordan, Giles, James, Zedde, Marialuisa, Pascarella, Rosario, Grisendi, Ilaria, Nzwalo, Hipolito, Liebeskind, David S., Molaie, Amir, Cavalier, Annie, Kam, Wayneho, Mac Grory, Brian, Al Kasab, Sami, Anadani, Mohammad, Kicielinski, Kimberly, Eltatawy, Ali, Chervak, Lina, Chulluncuy-Rivas, Roberto, Aziz, Yasmin, Bakradze, Ekaterina, Tran, Thanh Lam, Rodrigo-Gisbert, Marc, Requena, Manuel, Saleh Velez, Faddi, Ortiz Gracia, Jorge, Mudassani, Varsha, de Havenon, Adam, Vishnu, Venugopalan Y., Yaddanapudi, Sridhara, Adams, Latasha, Browngoehl, Abigail, Ranasinghe, Tamra, Dunston, Randy, Lynch, Zachary, Penckofer, Mary, Siegler, James, Mayer, Silvia, Willey, Joshua, Zubair, Adeel, Cheng, Yee Kuang, Sharma, Richa, Marto, João Pedro, Mendes Ferreira, Vítor, Klein, Piers, Nguyen, Thanh N., Asad, Syed Daniyal, Sarwat, Zoha, Balabhadra, Anvesh, Patel, Shivam, Secchi, Thais, Martins, Sheila, Mantovani, Gabriel, Kim, Young Dae, Krishnaiah, Balaji, Elangovan, Cheran, Lingam, Sivani, Quereshi, Abid, Fridman, Sebastian, Alvarado, Alonso, Khasiyev, Farid, Linares, Guillermo, Mannino, Marina, Terruso, Valeria, Vassilopoulou, Sofia, Tentolouris, Vasilis, Martinez-Marino, Manuel, Carrasco Wall, Victor, Indraswari, Fransisca, El Jamal, Sleiman, Liu, Shilin, Alvi, Muhammad, Ali, Farman, Sarvath, Mohammed, Morsi, Rami Z., Kass-Hout, Tareq, Shi, Feina, Zhang, Jinhua, Sokhi, Dilraj, Said, Jamil, Simpkins, Alexis N., Gomez, Roberto, Sen, Shayak, Ghani, Mohammad, Elnazeir, Marwa, Xiao, Han, Kala, Narendra, Khan, Farhan, Stretz, Christoph, Mohammadzadeh, Nahid, Goldstein, Eric, and Furie, Karen
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- 2024
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7. Drip-and-ship toward mothership model for mechanical thrombectomy during COVID-19 pandemic: a retrospective analysis
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Paolucci, Matteo, Biguzzi, Sara, Cordici, Francesco, Romoli, Michele, Altini, Mattia, Agnoletti, Vanni, Fabbri, Andrea, Francesconi, Raffaella, Menarini, Maurizio, Perin, Tiziana, Ruggiero, Maria, and Longoni, Marco
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- 2023
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8. Effect of tauroursodeoxycholic acid on survival and safety in amyotrophic lateral sclerosis: a retrospective population-based cohort study
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Ferri, Laura, Gessani, Annalisa, Liguori, Rocco, Cortelli, Pietro, Michelucci, Roberto, Salvi, Fabrizio, Bartolomei, Ilaria, Borghi, Anna Maria, Zini, Andrea, Rinaldi, Rita, Tugnoli, Valeria, Pugliatti, Maura, Codeluppi, Luca, Valzania, Franco, Stragliati, Filippo, Nuredini, Andi, Romano, Sonia, D'Orsi, Alessandro, Parrino, Liborio, Medici, Doriana, Pilurzi, Giovanna, Terlizzi, Emilio, Guidetti, Donata, De Pasqua, Silvia, Santangelo, Mario, De Massis, Paola, Gizzi, Matteo, Casmiro, Mario, Querzani, Pietro, Morresi, Simonetta, Vitiello, Maria, Longoni, Marco, Patuelli, Alberto, Malagù, Susanna, Bianchi, Francesca, Dossi, Marco Currò, Ganino, Cristiana, Zucchi, Elisabetta, Musazzi, Umberto Maria, Fedele, Guido, Martinelli, Ilaria, Gianferrari, Giulia, Simonini, Cecilia, Fini, Nicola, Ghezzi, Andrea, Caputo, Maria, Sette, Elisabetta, Vacchiano, Veria, Zinno, Lucia, Anceschi, Pietro, Canali, Elena, Vinceti, Marco, Ferro, Salvatore, and Mandrioli, Jessica
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- 2023
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9. Anti-LGI1 encephalitis following COVID-19 vaccination: a case series
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Asioli, Gian Maria, Muccioli, Lorenzo, Barone, Valentina, Giacomozzi, Sebastiano, Rossi, Simone, Silvestri, Tania, Spinardi, Luca, Mastrangelo, Vincenzo, Bernabè, Giorgia, Leta, Chiara, Brutto, Mariachiara, Faggiano, Chiara, Liguori, Rocco, Bisulli, Francesca, Longoni, Marco, Tinuper, Paolo, Guarino, Maria, and Cortelli, Pietro
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- 2022
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10. A case of Kennedy terminal ulcer in a 17th-century Italian mummy
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Traversari, Mirko, primary, Ventura, Luca, additional, Iwaszczonek, Aleksander Sebastian, additional, Cilli, Elisabetta, additional, Longoni, Marco, additional, Pasquinelli, Gianandrea, additional, Troncone, Giancarlo, additional, Brunetti, Arturo, additional, Melandri, Davide, additional, and Bellevicine, Claudio, additional
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- 2024
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11. Stress hyperglycemia is associated with futile recanalization in patients with anterior large vessel occlusion undergoing mechanical thrombectomy
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Merlino, Giovanni, primary, Romoli, Michele, additional, Ornello, Raffaele, additional, Foschi, Matteo, additional, Del Regno, Caterina, additional, Toraldo, Francesco, additional, Marè, Alessandro, additional, Cordici, Francesco, additional, Trosi, Alessio, additional, Longoni, Marco, additional, Kuris, Fedra, additional, Tereshko, Yan, additional, Lorenzut, Simone, additional, Gentile, Carolina, additional, Janes, Francesco, additional, Bax, Francesco, additional, Sponza, Massimo, additional, Gavrilovic, Vladimir, additional, Banerjee, Soma, additional, Sacco, Simona, additional, Gigli, Gian Luigi, additional, D’Anna, Lucio, additional, and Valente, Mariarosaria, additional
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- 2024
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12. Identifying and predicting amyotrophic lateral sclerosis clinical subgroups: a population-based machine-learning study
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Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Canosa, Antonio, Manera, Umberto, Vasta, Rosario, Palumbo, Francesca, Bombaci, Alessandro, Grassano, Maurizio, Brunetti, Maura, Casale, Federico, Fuda, Giuseppe, Salamone, Paolina, Iazzolino, Barbara, Peotta, Laura, Cugnasco, Paolo, De Marco, Giovanni, Torrieri, Maria Claudia, Gallone, Salvatore, Barberis, Marco, Sbaiz, Luca, Gentile, Salvatore, Mauro, Alessandro, Mazzini, Letizia, De Marchi, Fabiola, Corrado, Lucia, D'Alfonso, Sandra, Bertolotto, Antonio, Imperiale, Daniele, De Mattei, Marco, Amarù, Salvatore, Comi, Cristoforo, Labate, Carmelo, Poglio, Fabio, Ruiz, Luigi, Testa, Lucia, Rota, Eugenia, Ghiglione, Paolo, Launaro, Nicola, Di Sapio, Alessia, Mandrioli, Jessica, Fini, Nicola, Martinelli, Ilaria, Zucchi, Elisabetta, Gianferrari, Giulia, Simonini, Cecilia, Meletti, Stefano, Liguori, Rocco, Vacchiano, Veria, Salvi, Fabrizio, Bartolomei, Ilaria, Michelucci, Roberto, Cortelli, Pietro, Rinaldi, Rita, Borghi, Anna Maria, Zini, Andrea, Sette, Elisabetta, Tugnoli, Valeria, Pugliatti, Maura, Canali, Elena, Codeluppi, Luca, Valzania, Franco, Zinno, Lucia, Pavesi, Giovanni, Medici, Doriana, Pilurzi, Giovanna, Terlizzi, Emilio, Guidetti, Donata, De Pasqua, Silvia, Santangelo, Mario, De Massis, Patrizia, Bracaglia, Martina, Casmiro, Mario, Querzani, Pietro, Morresi, Simonetta, Longoni, Marco, Patuelli, Alberto, Malagù, Susanna, Currò Dossi, Marco, Vidale, Simone, Ferro, Salvatore, Faghri, Faraz, Brunn, Fabian, Dadu, Anant, Nalls, Michael A, Campbell, Roy H, and Traynor, Bryan J
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- 2022
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13. Applying Telemedicine for Stroke Remote Diagnosis: the TeleStroke System
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Croatti, Angelo, Longoni, Marco, and Montagna, Sara
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- 2022
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14. 18FFlutemetamol-PET Aided Classification of Cerebral Amyloid Angiopathy: A Multicenter Study.
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Romoli, Michele, Marinoni, Giulia, Tagliabue, Luca, Capozza, Antonella, Matteucci, Federica, Mattone, Vincenzo, Longoni, Marco, Cenni, Patrizia, Ruggiero, Maria, Rifino, Nicola, Canavero, Isabella, Boncoraglio, Giorgio, Stanziano, Mario, Bersano, Anna, and Storti, Benedetta
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- 2024
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15. Mechanical Thrombectomy in Ischemic Stroke with a Large Infarct Core: A Meta-Analysis of Randomized Controlled Trials.
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Romoli, Michele, Princiotta Cariddi, Lucia, Longoni, Marco, Stufano, Gianluca, Giacomozzi, Sebastiano, Pompei, Luca, Diana, Francesco, D'Anna, Lucio, Sacco, Simona, and Vidale, Simone
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ISCHEMIC stroke ,INTRACRANIAL hemorrhage ,RANDOMIZED controlled trials ,ENDOVASCULAR surgery ,THERAPEUTICS - Abstract
Background/Objectives: Endovascular treatment (EVT) is recommended for acute ischemic stroke due to large-vessel occlusion (LVO) and an Alberta Stroke Program Early CT Score (ASPECTS) ≥ 6. Randomized controlled trials (RCTs) have recently become available on EVT effects in people with LVO-related large core stroke (ASPECTS 0–5). Here, we provide an updated meta-analysis of the EVT effect on functional neurological status in people with large-core stroke. Methods: The study followed the PRISMA guidelines. PubMed, EMBASE and Cochrane Central were searched for RCTs comparing EVT vs. best medical treatment (BMT) in large-core LVO stroke. The primary outcome was functional independence at 90 days (modified Rankin Scale; mRS 0–2). The secondary outcomes were symptomatic intracranial hemorrhage (sICH), good functional outcome (mRS 0–3) and excellent functional outcome (mRS 0–1). EVT vs. BMT was compared through random effect meta-analysis. Heterogeneity was assessed with the I
2 and Q test and risk of bias reported according to the RoB2 tool. Results: Six RCTs were included (n = 1656 patients). All studies had a moderate risk of bias, with blinding bias due to the nature of the intervention, potential allocation bias and incomplete outcome reporting. Functional independence was significantly more frequent in the EVT vs. BMT group (OR = 2.47, 95% CI = 1.52–4.03, p < 0.001). sICH rates (OR = 1.77, 95% CI = 1.01–3.11, p = 0.04) and good functional outcome (OR = 2.20; 95% CI = 1.72–2.81, p < 0.001) were more frequent in the EVT vs. BMT group, while the rates of mRS 0–1 did not differ. Conclusions: In patients with large-core stroke and LVO, EVT plus BMT as compared to BMT alone carries a significant increase in independent ambulation and good functional outcome at 3 months despite the marginal increase in sICH. [ABSTRACT FROM AUTHOR]- Published
- 2024
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16. Predictors of futile recanalization in nonagenarians treated with mechanical thrombectomy: a multi-center observational study.
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D'Anna, Lucio, Merlino, Giovanni, Romoli, Michele, Zhang, Liqun, Del Regno, Caterina, Aggour, Mohammed, Levee, Viva, Foschi, Matteo, Sponza, Massimo, Toraldo, Francesco, Algazlan, Razan, Ruggiero, Maria, Longoni, Marco, Lobotesis, Kyriakos, Abu-Rumeileh, Samir, Bagatto, Daniele, Mansoor, Nina, Gigli, Gian Luigi, Valente, Mariarosaria, and Banerjee, Soma
- Subjects
ISCHEMIC stroke ,THROMBECTOMY ,NONAGENARIANS ,PATIENTS' attitudes ,THROMBOLYTIC therapy - Abstract
Background: There is a lack of data regarding patients aged 90 years or older undergoing mechanical thrombectomy and their predictors of futile recanalization. Aims: We sought to evaluate the predictors of futile recanalization in patients ≥ 90 years with large vessel occlusion undergoing mechanical thrombectomy. Methods: This multi-center observational retrospective study included patients ≥ 90 years consecutively treated with mechanical thrombectomy in four thrombectomy capable centers between January 1st, 2016 and 30th March 2023. Futile recanalization was defined as large vessel occlusion patients experiencing a 90-day poor outcome (mRS 3–6) despite successful recanalization (mTICI ≥ 2b) after mechanical thrombectomy. Results: Our cohort included 139 patients ≥ 90 years with acute ischemic stroke due to anterior circulation large vessel occlusion treated with mechanical thrombectomy. One hundred seventeen of one hundred thirty-nine patients ≥ 90 years who achieved successful recanalization were included in the analysis (seventy-six female (64.9%)), of whom thirty-one (26.49%) experienced effective recanalization and eighty-six (73.51%) experienced futile recanalization. Patients with futile recanalization had higher NIHSS on admission (p < 0.001); they were less frequently treated with intravenous thrombolysis (p = 0.048), had more often general anesthesia (p = 0.011), and longer door to groin puncture delay (p = 0.002). Univariable regression analysis showed that use of intravenous thrombolysis (0.29, 95% CI 0.02–0.79, p = 0.034) and site of occlusion distal vs proximal (0.34, 95% CI 0.11–0.97, p = 0.044) were associated with reduced probability of futile recanalization while NIHSS on admission (1.29, 95% CI 1.16–1.45, p < 0.001), NIHSS at 24 h (1.15, 95% CI 1.07–1.25, p = 0.002), type of anesthesia used (4.18, 95% CI 1.57–11.08, p = 0.004), and door to groin puncture time (1.02, 95% CI 1.00–1.05, p = 0.005) were associated with increased probability of futile recanalization. Multivariable regression analysis showed that use of intravenous thrombolysis (0.44, 95% CI 0.09–0.88, p = 0.039) was associated with reduced probability of futile recanalization. Conclusion: Our study seems to suggest that mechanical thrombectomy with intravenous thrombolysis is associated with reduced probability of futile recanalization in a multi-center cohort of patients aged 90 years or older. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Effect of tauroursodeoxycholic acid on survival and safety in amyotrophic lateral sclerosis: a retrospective population-based cohort study
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Zucchi, Elisabetta, primary, Musazzi, Umberto Maria, additional, Fedele, Guido, additional, Martinelli, Ilaria, additional, Gianferrari, Giulia, additional, Simonini, Cecilia, additional, Fini, Nicola, additional, Ghezzi, Andrea, additional, Caputo, Maria, additional, Sette, Elisabetta, additional, Vacchiano, Veria, additional, Zinno, Lucia, additional, Anceschi, Pietro, additional, Canali, Elena, additional, Vinceti, Marco, additional, Ferro, Salvatore, additional, Mandrioli, Jessica, additional, Ferri, Laura, additional, Gessani, Annalisa, additional, Liguori, Rocco, additional, Cortelli, Pietro, additional, Michelucci, Roberto, additional, Salvi, Fabrizio, additional, Bartolomei, Ilaria, additional, Borghi, Anna Maria, additional, Zini, Andrea, additional, Rinaldi, Rita, additional, Tugnoli, Valeria, additional, Pugliatti, Maura, additional, Codeluppi, Luca, additional, Valzania, Franco, additional, Stragliati, Filippo, additional, Nuredini, Andi, additional, Romano, Sonia, additional, D'Orsi, Alessandro, additional, Parrino, Liborio, additional, Medici, Doriana, additional, Pilurzi, Giovanna, additional, Terlizzi, Emilio, additional, Guidetti, Donata, additional, De Pasqua, Silvia, additional, Santangelo, Mario, additional, De Massis, Paola, additional, Gizzi, Matteo, additional, Casmiro, Mario, additional, Querzani, Pietro, additional, Morresi, Simonetta, additional, Vitiello, Maria, additional, Longoni, Marco, additional, Patuelli, Alberto, additional, Malagù, Susanna, additional, Bianchi, Francesca, additional, Dossi, Marco Currò, additional, and Ganino, Cristiana, additional
- Published
- 2023
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18. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context
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Sormani, Maria Pia, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri Rossi, Beatrice Maria, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, dʼAmbrosio, Alessandro, DʼAmico, Emanuele, Danni, Maura Chiara, dʼArma, Alessia, Dattola, Vincenzo, de Biase, Stefano, Luca, Giovanna De, Mercanti, Stefania Federica De, De Mitri, Paolo, De Stefano, Nicola, Cava, Marco Della, Napoli, Mario di, Sapio, Alessia Di, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Diana, Ferraro, Ferrò, Maria Teresa, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Furlan, Roberto, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grasso, Maria Grazia, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Infante, Maria Teresa, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Landi, Doriana, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, LʼEpiscopo, Maria Rita, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Mancinelli, Chiara Rosa, Mancinelli, Luca, Manganotti, Paolo, Maniscalco, Giorgia Teresa, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Marinelli, Fabiana, Marti, Alessandro, Boneschi, Filippo Martinelli, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Moiola, Lucia, Montepietra, Sara, MontiBragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Nicoletti, Carolina Gabri, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, Pietroboni, Anna M, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Rilla, Maria Teresa, Rinaldi, Francesca, Romano, Calogero Marcello, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Scarano, Giuditta Ilaria, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Stromillo, Maria Laura, Strumia, Silvia, Susani, Emanuela Laura, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Torri, Clerici Valentina, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Verrengia, Elena Pinuccia, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Zarbo, Ignazio Roberto, and Zuliani, Luigi
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- 2022
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19. Predictors for hemorrhagic transformation and cerebral edema in stroke patients with first-pass complete recanalization
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Cappellari, Manuel, primary, Pracucci, Giovanni, additional, Saia, Valentina, additional, Sallustio, Fabrizio, additional, Casetta, Ilaria, additional, Fainardi, Enrico, additional, Capasso, Francesco, additional, Nencini, Patrizia, additional, Vallone, Stefano, additional, Bigliardi, Guido, additional, Saletti, Andrea, additional, De Vito, Alessandro, additional, Ruggiero, Maria, additional, Longoni, Marco, additional, Semeraro, Vittorio, additional, Boero, Giovanni, additional, Silvagni, Umberto, additional, Stancati, Furio, additional, Lafe, Elvis, additional, Mazzacane, Federico, additional, Bracco, Sandra, additional, Tassi, Rossana, additional, Comelli, Simone, additional, Melis, Maurizio, additional, Romano, Daniele, additional, Napoletano, Rosa, additional, Menozzi, Roberto, additional, Scoditti, Umberto, additional, Chiumarulo, Luigi, additional, Petruzzellis, Marco, additional, Vinci, Sergio Lucio, additional, Ferraù, Ludovica, additional, Taglialatela, Francesco, additional, Zini, Andrea, additional, Sanna, Antioco, additional, Tassinari, Tiziana, additional, Iacobucci, Marta, additional, Nicolini, Ettore, additional, Bergui, Mauro, additional, Cerrato, Paolo, additional, Giorgianni, Andrea, additional, Princiotta Cariddi, Lucia, additional, Amistà, Pietro, additional, Russo, Monia, additional, Gallesio, Ivan, additional, Sepe, Federica, additional, Comai, Alessio, additional, Franchini, Enrica, additional, Filauri, Pietro, additional, Orlandi, Berardino, additional, Besana, Michele, additional, Giossi, Alessia, additional, Lazzarotti, Guido Andrea, additional, Orlandi, Giovanni, additional, Castellano, Davide, additional, Naldi, Andrea, additional, Plebani, Mauro, additional, Zivelonghi, Cecilia, additional, Invernizzi, Paolo, additional, Mangiafico, Salvatore, additional, and Toni, Danilo, additional
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- 2023
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20. Insight into Elderly ALS Patients in the Emilia Romagna Region: Epidemiological and Clinical Features of Late-Onset ALS in a Prospective, Population-Based Study
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Gianferrari, Giulia, Martinelli, Ilaria, Simonini, Cecilia, Zucchi, Elisabetta, Fini, Nicola, Caputo, Maria, Ghezzi, Andrea, Gessani, Annalisa, Canali, Elena, Casmiro, Mario, De Massis, Patrizia, Curro' Dossi, Marco, De Pasqua, Silvia, Liguori, Rocco, Longoni, Marco, Medici, Doriana, Morresi, Simonetta, Patuelli, Alberto, Pugliatti, Maura, Santangelo, Mario, Sette, Elisabetta, Stragliati, Filippo, Terlizzi, Emilio, Vacchiano, Veria, Zinno, Lucia, Ferro, Salvatore, Amedei, Amedeo, Filippini, Tommaso, Vinceti, Marco, Errals Group, Null, and Mandrioli, Jessica
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amyotrophic lateral sclerosis ,phenotype ,elderly ALS ,epidemiology ,prognosis ,survival - Published
- 2023
21. Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular events : a 1-year follow-up
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Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Vanguru, Husitha Reddy, Lesaine, Emilie, Tsivgoulis, Georgios, Loochtan, Aaron, I, Demeestere, Jelle, Uchino, Ken, Inoa, Violiza, Goyal, Nitin, Charidimou, Andreas, Siegler, James E., Yaghi, Shadi, de Sousa, Diana Aguiar, Mohammaden, Mahmoud H., Haussen, Diogo C., Kristoffersen, Espen Saxhaug, Lereis, Virginia Pujol, Scollo, Sergio Daniel, Campbell, Bruce C.V., Ma, Alice, Thomas, James Orton, Parsons, Mark W., Singhal, Shaloo, Slater, Lee-Anne, Martins, Rodrigo Tomazini, Enzinger, Chris, Gattringer, Thomas, Rahman, Aminur, Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C.T., de Neves, Luciana Oliveira, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, de Silva, Isabelle Lameirinhas, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Angel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Skorna, Miroslav, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Nolte, Christian H., Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Gotz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, Jose Dominguo, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P.N., Pramana, Nyoman Angga Krishna, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Abu Raya, Tariq, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Zaidi, Wan Asyraf Wan, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Coutinho, Jonathan M., Rinkel, Leon A., Dippel, Diederik W.J., Van dam-Nolen, Dianne H.K., Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Yalung, Patrick Matic, Dy, Jon Stewart Hao, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Fonseca, Luisa, Marto, Joao Pedro, Pinho e Melo, Teresa, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Mako, Miroslav, Ayo-Martin, Oscar, Hernandez-Ferandez, Francisco, Blasco, Jordi, Rodriguez-Vazquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Perez-Sanchez, Soledad, Garcia Sanchez, Maria Jesas, Guillan Rodriguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T.P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Azcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Bahiru, Zeelalem, Below, Kristine, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Khatri, Rakesh, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutierrez, Santiago, Puri, Ajit S., Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, Jose Rafael, Rost, Natalia S., Rothstein, Aaron, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Huynh Vu Le, Quy Viet Nguyen, Thong Nhu Pham, Trung Thanh Nguyen, Hoang Thi Phan, Mai Duy Ton, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., Nogueira, Raul G., SVIN COVID-19 Global Stroke Registry, Neurology, ACS - Atherosclerosis & ischemic syndromes, ANS - Neurovascular Disorders, Graduate School, and Radiology & Nuclear Medicine
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Neurology (clinical) ,Human medicine - Abstract
Background and ObjectivesDeclines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).MethodsWe conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by theirICD-10codes or classifications in stroke databases.ResultsThere were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1–6.9];p< 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1–4.6];p< 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4–5.8];p< 0.0001). Larger declines were observed at high-volume compared with low-volume centers (allp< 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6–0.9];p= 0.49). Stroke was diagnosed in 1.3% [1.31–1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82–2.97], 5,656/195,539) of all stroke hospitalizations.DiscussionThere was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.Trial Registration InformationThis study is registered underNCT04934020.
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- 2023
22. Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular events
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Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Vanguru, Husitha Reddy, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Lesaine, Emilie, Nolte, Christian H., Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, Jose Dominguo, Tsivgoulis, Georgios, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P.N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Loochtan, Aaron I., Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Demeestere, Jelle, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Uchino, Ken, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Inoa, Violiza, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Goyal, Nitin, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Charidimou, Andreas, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Siegler, James E., Coutinho, Jonathan M., Rinkel, Leon A., Dippel, Diederik W.J., van Dam-Nolen, Dianne H.K., Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Yaghi, Shadi, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, de Sousa, Diana Aguiar, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Mohammaden, Mahmoud H., Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Haussen, Diogo C., Fonseca, Luisa, Marto, João Pedro, Melo, Teresa Pinho e, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Kristoffersen, Espen Saxhaug, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Perez-Sanchez, Soledad, García Sánchez, María Jesús, Lereis, Virginia Pujol, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T.P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Scollo, Sergio Daniel, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Özcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, Campbell, Bruce C. V., John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Ma, Alice, Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Thomas, James Orton, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Parsons, Mark W., Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Singhal, Shaloo, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Slater, Lee-Anne, Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutierrez, Santiago, Tomazini Martins, Rodrigo, Puri, Ajit S., Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, Jose Rafael, Rost, Natalia S., Rothstein, Aaron, Enzinger, Chris, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Gattringer, Thomas, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., Rahman, Aminur, Nogueira, Raul G., Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C.T., de Oliveira Neves, Luciana, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Lameirinhas da Silva, Isabelle, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Angel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, and Repositório da Universidade de Lisboa
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© 2022 American Academy of Neurology, Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020). Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results: There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations. Discussion: There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.
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- 2023
23. Myelomatous meningitis diagnosed by cerebrospinal fluid cytology examination.
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Bizzarro, Tommaso, De Marco, Giovanna, Romoli, Michele, Paolucci, Lina, Morigi, Federico, Longoni, Marco, and Bartolini, Daniela
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CEREBROSPINAL fluid examination ,MENINGITIS ,PLASMA cell diseases ,DIAGNOSIS ,CEREBROSPINAL fluid ,CAUDA equina ,CELL morphology - Abstract
This article, published in the journal Cytopathology, discusses the diagnosis of myelomatous meningitis through cerebrospinal fluid cytology examination. Myelomatous meningitis is a rare complication of multiple myeloma, a neoplastic plasma cell disorder. The article presents a case study of a 72-year-old woman with a history of IgA-lambda multiple myeloma who developed symptoms of headache, disequilibrium, and neurological deficits. Cerebrospinal fluid analysis, combined with immunocytochemistry, confirmed the presence of myeloma cells in the central nervous system, leading to a diagnosis of myelomatous meningitis. The article emphasizes the importance of prompt diagnosis and multidisciplinary approaches in managing this condition. [Extracted from the article]
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- 2024
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24. Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality
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Nguyen, Thanh N, Qureshi, Muhammad M, Klein, Piers, Yamagami, Hiroshi, Abdalkader, Mohamad, Mikulik, Robert, Sathya, Anvitha, Mansour, Ossama Yassin, Czlonkowska, Anna, Hannah, Lo, Field, Thalia S, Charidimou, Andreas, Banerjee, Soma, Yaghi, Shadi, Siegler, James E, Sedova, Petra, Kwan, Joseph, de Sousa, Diana Aguiar, Demeestere, Jelle, Inoa, Violiza, Omran, Setareh Salehi, Zhang, Liqun, Michel, Patrik, Strambo, Davide, Marto, João Pedro, Nogueira, Raul G, Kristoffersen, Espen Saxhaug, Tsivgoulis, Georgios, Lereis, Virginia Pujol, Alice, Ma, Enzinger, Christian, Gattringer, Thomas, Rahman, Aminur, Bonnet, Thomas, Ligot, Noémie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C T, Mora Cuervo, Daissy Liliana, de Oliveira Neves, Luciana, Lameirinhas da Silva, Isabelle, Martíns, Rodrigo Targa, Rebello, Letícia C, Santiago, Igor Bessa, Sadelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Cora, Elena Adela, Kelly, Michael E, Peeling, Lissa, Pikula, Aleksandra, Chen, Hui-Sheng, Chen, Yimin, Yang, Shuiquan, Roje Bedekovic, Marina, Čabal, Martin, Tenora, Dusan, Fibrich, Petr, Dušek, Pavel, Hlaváčová, Helena, Hrabanovska, Emanuela, Jurák, Lubomír, Kadlčíková, Jana, Karpowicz, Igor, Klečka, Lukáš, Kovář, Martin, Neumann, Jiří, Paloušková, Hana, Reiser, Martin, Rohan, Vladimir, Šimůnek, Libor, Skoda, Ondreij, Škorňa, Miroslav, Šrámek, Martin, Drenck, Nicolas, Sobh, Khalid, Lesaine, Emilie, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Strbian, Daniel, Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, José Dominguo, Huded, Vikram, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P N, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Sadeghi Hokmabadi, Elyar, Hashemilar, Mazyar, Sabetay, Sergiu Ionut, Rahal, Fadi, Acampa, Maurizio, Adami, Alessandro, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Sakai, Kenichiro, Fukuda, Hiroki, Fujita, Kyohei, Imamura, Hirotoshi, Kosuke, Miyake, Sakaguchi, Manabu, Sonoda, Kazutaka, Matsumaru, Yuji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Sakai, Nobuyuki, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Sohn, Sung-Il, Lee, Jin Soo, Arsovska, Anita Ante, Chieh, Chan Yong, Wan Zaidi, Wan Asyraf, Wan Yahya, Wan Nur Nafisah, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Dippel, Diederik, van Dam-Nolen, Dianne H K, Teddy Y, Wu, Punter, Martin, Adebayo, Tajudeen Temitayo, Bello, Abiodun H, Sunmonu, Taofiki Ajao, Wahab, Kolawole Wasiu, Sundseth, Antje, Al Hashmi, Amal M, Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Jon Stewart Hao, Dy, Brola, Waldemar, Dębiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M, Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Sobolewski, Piotr, Wiącek, Marcin, Zielinska-Turek, Justyna, Araújo, André Pinho, Rocha, Mariana, Castro, Pedro, Ferreira, Patricia, Nunes, Ana Paiva, Fonseca, Luísa, Pinho E Melo, Teresa, Rodrigues, Miguel, Silva, M Luis, Ciopleias, Bogdan, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Haring, Jozef, Ayo-Martin, Oscar, Hernandez-Fernandez, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Perez-Sanchez, Soledad, García Sánchez, María Jesús, Guillán Rodríguez, Marta, Bernava, Gianmarco, Bolognese, Manuel, Carrera, Emmanuel, Churojana, Anchalee, Aykac, Ozlem, Özdemir, Atilla Özcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed I, John, Seby, Krishnan, Kailash, Lenthall, Robert, Asif, Kaiz S, Below, Kristine, Biller, Jose, Chen, Michael, Chebl, Alex, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam H, Dharmadhikari, Sushrut, Eskey, Clifford J, Farooqui, Mudassir, Feske, Steven K, Goyal, Nitin, Grimmett, Kasey B, Guzik, Amy K, Haussen, Diogo C, Hovingh, Majesta, Jillela, Dinesh, Kan, Peter T, Khatri, Rakesh, Khoury, Naim N, Kiley, Nicole L, Kolikonda, Murali K, Lara, Stephanie, Grace, Li, Linfante, Italo, Loochtan, Aaron I, Lopez, Carlos D, Lycan, Sarah, Male, Shailesh S, Nahab, Fadi, Maali, Laith, Masoud, Hesham E, Min, Jiangyong, Orgeta-Gutierrez, Santiago, Mohamed, Ghada A, Mohammaden, Mahmoud, Nalleballe, Krishna, Radaideh, Yazan, Ramakrishnan, Pankajavalli, Rayo-Taranto, Bliss, Rojas-Soto, Diana M, Ruland, Sean, Simpkins, Alexis N, Sheth, Sunil A, Starosciak, Amy K, Tarlov, Nicholas E, Taylor, Robert A, Voetsch, Barbara, Zhang, Linda, Duong, Hai Quang, Dao, Viet-Phuong, Huynh Vu, Le, Pham, Thong Nhu, Ton, Mai Duy, Tran, Anh Duc, Zaidat, Osama O, Machi, Paolo, Dirren, Elisabeth, Rodríguez Fernández, Claudio, Escartín López, Jorge, Fernández Ferro, Jose Carlos, Mohammadzadeh, Niloofar, Suryadevara, Neil C, de la Cruz Fernández, Beatriz, Bessa, Filipe, Jancar, Nina, Brady, Megan, Scozzari, Dawn, SVIN COVID-19 Global COVID Stroke Registry, Neurology, Radiology & Nuclear Medicine, Society of Vascular and Interventional Neurology, Nguyen, Thanh N., Nogueira, Raul G., Clinical sciences, Neuroprotection & Neuromodulation, Biology, Neurologian yksikkö, HUS Neurocenter, and Helsinki University Hospital Area
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Stroke ,Vaccine-induced immune thrombotic thrombocytopenia ,SDG 3 - Good Health and Well-being ,Cerebral venous thrombosis ,SARS-CoV-2 ,3112 Neurosciences ,COVID-19 ,Mortality ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,3124 Neurology and psychiatry - Abstract
[Background and Purpose] Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year., [Methods] We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020)., [Results] There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P, [Conclusions] During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT., The study was funded by the Society of Vascular and Interventional Neurology research pilot grant.
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- 2022
25. Thrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis
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Romoli, Michele, primary, Matteo, Eleonora, additional, Migliaccio, Ludovica, additional, Gentile, Mauro, additional, Mosconi, Maria Giulia, additional, Scura, Giuseppe Maria, additional, Naccarato, Marcello, additional, Colangeli, Enrico, additional, Candelaresi, Paolo, additional, Andreone, Vincenzo, additional, Giammello, Fabrizio, additional, Fortunata Musolino, Rosa, additional, Dell’Aera, Cristina, additional, Sepe, Federica Nicoletta, additional, Pronello, Edoardo, additional, Barbarini, Leonardo, additional, Caggiula, Marcella, additional, Rizzo, Federica, additional, Petruzzellis, Marco, additional, Giorli, Elisa, additional, Zedde, Maria Luisa, additional, Anticoli, Sabrina, additional, Mangiardi, Marilena, additional, Muto, Mario, additional, Diana, Francesco, additional, De Angelis, Maria Vittoria, additional, Digiovanni, Anna, additional, Concari, Letizia, additional, La Gioia, Sara, additional, Sessa, Maria, additional, Biguzzi, Sara, additional, Cordici, Francesco, additional, Longoni, Marco, additional, Ruggiero, Maria, additional, Cenciarelli, Silvia, additional, Eusebi, Paolo, additional, Sacco, Simona, additional, Caso, Valeria, additional, Paciaroni, Maurizio, additional, Ricci, Stefano, additional, Zini, Andrea, additional, Toni, Danilo, additional, and Giannandrea, David, additional
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- 2022
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26. Identifying and predicting amyotrophic lateral sclerosis clinical subgroups: a population-based machine-learning study
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Faghri, Faraz, primary, Brunn, Fabian, additional, Dadu, Anant, additional, Zucchi, Elisabetta, additional, Martinelli, Ilaria, additional, Mazzini, Letizia, additional, Vasta, Rosario, additional, Canosa, Antonio, additional, Moglia, Cristina, additional, Calvo, Andrea, additional, Nalls, Michael A, additional, Campbell, Roy H, additional, Mandrioli, Jessica, additional, Traynor, Bryan J, additional, Chiò, Adriano, additional, Manera, Umberto, additional, Palumbo, Francesca, additional, Bombaci, Alessandro, additional, Grassano, Maurizio, additional, Brunetti, Maura, additional, Casale, Federico, additional, Fuda, Giuseppe, additional, Salamone, Paolina, additional, Iazzolino, Barbara, additional, Peotta, Laura, additional, Cugnasco, Paolo, additional, De Marco, Giovanni, additional, Torrieri, Maria Claudia, additional, Gallone, Salvatore, additional, Barberis, Marco, additional, Sbaiz, Luca, additional, Gentile, Salvatore, additional, Mauro, Alessandro, additional, De Marchi, Fabiola, additional, Corrado, Lucia, additional, D'Alfonso, Sandra, additional, Bertolotto, Antonio, additional, Imperiale, Daniele, additional, De Mattei, Marco, additional, Amarù, Salvatore, additional, Comi, Cristoforo, additional, Labate, Carmelo, additional, Poglio, Fabio, additional, Ruiz, Luigi, additional, Testa, Lucia, additional, Rota, Eugenia, additional, Ghiglione, Paolo, additional, Launaro, Nicola, additional, Di Sapio, Alessia, additional, Fini, Nicola, additional, Gianferrari, Giulia, additional, Simonini, Cecilia, additional, Meletti, Stefano, additional, Liguori, Rocco, additional, Vacchiano, Veria, additional, Salvi, Fabrizio, additional, Bartolomei, Ilaria, additional, Michelucci, Roberto, additional, Cortelli, Pietro, additional, Rinaldi, Rita, additional, Borghi, Anna Maria, additional, Zini, Andrea, additional, Sette, Elisabetta, additional, Tugnoli, Valeria, additional, Pugliatti, Maura, additional, Canali, Elena, additional, Codeluppi, Luca, additional, Valzania, Franco, additional, Zinno, Lucia, additional, Pavesi, Giovanni, additional, Medici, Doriana, additional, Pilurzi, Giovanna, additional, Terlizzi, Emilio, additional, Guidetti, Donata, additional, De Pasqua, Silvia, additional, Santangelo, Mario, additional, De Massis, Patrizia, additional, Bracaglia, Martina, additional, Casmiro, Mario, additional, Querzani, Pietro, additional, Morresi, Simonetta, additional, Longoni, Marco, additional, Patuelli, Alberto, additional, Malagù, Susanna, additional, Currò Dossi, Marco, additional, Vidale, Simone, additional, and Ferro, Salvatore, additional
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- 2022
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27. sj-docx-1-eso-10.1177_23969873221131635 – Supplemental material for Thrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis
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Romoli, Michele, Matteo, Eleonora, Migliaccio, Ludovica, Gentile, Mauro, Mosconi, Maria Giulia, Scura, Giuseppe Maria, Naccarato, Marcello, Colangeli, Enrico, Candelaresi, Paolo, Andreone, Vincenzo, Giammello, Fabrizio, Fortunata Musolino, Rosa, Dell’Aera, Cristina, Sepe, Federica Nicoletta, Pronello, Edoardo, Barbarini, Leonardo, Caggiula, Marcella, Rizzo, Federica, Petruzzellis, Marco, Giorli, Elisa, Zedde, Maria Luisa, Anticoli, Sabrina, Mangiardi, Marilena, Muto, Mario, Diana, Francesco, De Angelis, Maria Vittoria, Digiovanni, Anna, Concari, Letizia, La Gioia, Sara, Sessa, Maria, Biguzzi, Sara, Cordici, Francesco, Longoni, Marco, Ruggiero, Maria, Cenciarelli, Silvia, Eusebi, Paolo, Sacco, Simona, Caso, Valeria, Paciaroni, Maurizio, Ricci, Stefano, Zini, Andrea, Toni, Danilo, and Giannandrea, David
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FOS: Clinical medicine ,Cardiology ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental material, sj-docx-1-eso-10.1177_23969873221131635 for Thrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis by Michele Romoli, Eleonora Matteo, Ludovica Migliaccio, Mauro Gentile, Maria Giulia Mosconi, Giuseppe Maria Scura, Marcello Naccarato, Enrico Colangeli, Paolo Candelaresi, Vincenzo Andreone, Fabrizio Giammello, Rosa Fortunata Musolino, Cristina Dell’Aera, Federica Nicoletta Sepe, Edoardo Pronello, Leonardo Barbarini, Marcella Caggiula, Federica Rizzo, Marco Petruzzellis, Elisa Giorli, Maria Luisa Zedde, Sabrina Anticoli, Marilena Mangiardi, Mario Muto, Francesco Diana, Maria Vittoria De Angelis, Anna Digiovanni, Letizia Concari, Sara La Gioia, Maria Sessa, Sara Biguzzi, Francesco Cordici, Marco Longoni, Maria Ruggiero, Silvia Cenciarelli, Paolo Eusebi, Simona Sacco, Valeria Caso, Maurizio Paciaroni, Stefano Ricci, Andrea Zini, Danilo Toni and David Giannandrea in European Stroke Journal
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- 2022
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28. sj-docx-2-eso-10.1177_23969873221131635 – Supplemental material for Thrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis
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Romoli, Michele, Matteo, Eleonora, Migliaccio, Ludovica, Gentile, Mauro, Mosconi, Maria Giulia, Scura, Giuseppe Maria, Naccarato, Marcello, Colangeli, Enrico, Candelaresi, Paolo, Andreone, Vincenzo, Giammello, Fabrizio, Fortunata Musolino, Rosa, Dell’Aera, Cristina, Sepe, Federica Nicoletta, Pronello, Edoardo, Barbarini, Leonardo, Caggiula, Marcella, Rizzo, Federica, Petruzzellis, Marco, Giorli, Elisa, Zedde, Maria Luisa, Anticoli, Sabrina, Mangiardi, Marilena, Muto, Mario, Diana, Francesco, De Angelis, Maria Vittoria, Digiovanni, Anna, Concari, Letizia, La Gioia, Sara, Sessa, Maria, Biguzzi, Sara, Cordici, Francesco, Longoni, Marco, Ruggiero, Maria, Cenciarelli, Silvia, Eusebi, Paolo, Sacco, Simona, Caso, Valeria, Paciaroni, Maurizio, Ricci, Stefano, Zini, Andrea, Toni, Danilo, and Giannandrea, David
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FOS: Clinical medicine ,Cardiology ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental material, sj-docx-2-eso-10.1177_23969873221131635 for Thrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis by Michele Romoli, Eleonora Matteo, Ludovica Migliaccio, Mauro Gentile, Maria Giulia Mosconi, Giuseppe Maria Scura, Marcello Naccarato, Enrico Colangeli, Paolo Candelaresi, Vincenzo Andreone, Fabrizio Giammello, Rosa Fortunata Musolino, Cristina Dell’Aera, Federica Nicoletta Sepe, Edoardo Pronello, Leonardo Barbarini, Marcella Caggiula, Federica Rizzo, Marco Petruzzellis, Elisa Giorli, Maria Luisa Zedde, Sabrina Anticoli, Marilena Mangiardi, Mario Muto, Francesco Diana, Maria Vittoria De Angelis, Anna Digiovanni, Letizia Concari, Sara La Gioia, Maria Sessa, Sara Biguzzi, Francesco Cordici, Marco Longoni, Maria Ruggiero, Silvia Cenciarelli, Paolo Eusebi, Simona Sacco, Valeria Caso, Maurizio Paciaroni, Stefano Ricci, Andrea Zini, Danilo Toni and David Giannandrea in European Stroke Journal
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- 2022
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29. Drip-and-ship toward mothership model for mechanical thrombectomy during COVID-19 pandemic: a retrospective analysis
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Paolucci, Matteo, primary, Biguzzi, Sara, additional, Cordici, Francesco, additional, Romoli, Michele, additional, Altini, Mattia, additional, Agnoletti, Vanni, additional, Fabbri, Andrea, additional, Francesconi, Raffaella, additional, Menarini, Maurizio, additional, Perin, Tiziana, additional, Ruggiero, Maria, additional, and Longoni, Marco, additional
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- 2022
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30. The benefit of a short-stay neurological observation unit in the COVID-19 era
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Paolucci, Matteo, Biguzzi, Sara, Bomprezzi, Chiara, Cordici, Francesco, Di Stasio, Flavio, Infante, Rossella, Mancinelli, Luca, Morresi, Simonetta, Postiglione, Emanuela, Preda, Francesca, Romoli, Michele, Terlizzi, Rossana, Vitiello, Maria, and Longoni, Marco
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- 2021
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31. Shift from drip-and-ship towards mothership model for mechanical thrombectomy during COVID-19 pandemic: A retrospective analysis of a stroke network performances
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Paolucci, Matteo, Ruggiero, Maria, Agnoletti, Vanni, Menarini, Maurizio, Francesconi, Raffaella, Perin, Tiziana, Fabbri, Andrea, Biguzzi, Sara, Cordici, Francesco, and Longoni, Marco
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- 2021
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32. The Genetic Landscape of Patent Foramen Ovale: A Systematic Review
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Paolucci, Matteo, primary, Vincenzi, Chiara, additional, Romoli, Michele, additional, Amico, Giulia, additional, Ceccherini, Isabella, additional, Lattanzi, Simona, additional, Bersano, Anna, additional, Longoni, Marco, additional, Sacco, Simona, additional, Vernieri, Fabrizio, additional, Pascarella, Rosario, additional, Valzania, Franco, additional, and Zedde, Marialuisa, additional
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- 2021
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33. Thrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis
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Romoli, Michele, Matteo, Eleonora, Migliaccio, Ludovica, Gentile, Mauro, Mosconi, Maria Giulia, Scura, Giuseppe Maria, Naccarato, Marcello, Colangeli, Enrico, Candelaresi, Paolo, Andreone, Vincenzo, Giammello, Fabrizio, Fortunata Musolino, Rosa, Dell’Aera, Cristina, Sepe, Federica Nicoletta, Pronello, Edoardo, Barbarini, Leonardo, Caggiula, Marcella, Rizzo, Federica, Petruzzellis, Marco, Giorli, Elisa, Zedde, Maria Luisa, Anticoli, Sabrina, Mangiardi, Marilena, Muto, Mario, Diana, Francesco, De Angelis, Maria Vittoria, Digiovanni, Anna, Concari, Letizia, La Gioia, Sara, Sessa, Maria, Biguzzi, Sara, Cordici, Francesco, Longoni, Marco, Ruggiero, Maria, Cenciarelli, Silvia, Eusebi, Paolo, Sacco, Simona, Caso, Valeria, Paciaroni, Maurizio, Ricci, Stefano, Zini, Andrea, Toni, Danilo, and Giannandrea, David
- Abstract
Introduction: Recent anticoagulant intake represents a contraindication for thrombolysis in acute ischemic stroke. Idarucizumab reverses the anticoagulant effect of dabigatran, potentially allowing for thrombolysis. This nation-wide observational cohort study, systematic review, and meta-analysis evaluated the efficacy and safety of thrombolysis preceded by dabigatran-reversal in people with acute ischemic stroke.Patients and methods: We recruited people undergoing thrombolysis following dabigatran-reversal at 17 stroke centers in Italy (reversal-group), people on dabigatran treated with thrombolysis without reversal (no-reversal group), and age, sex, hypertension, stroke severity, and reperfusion treatment-matched controls in 1:7 ratio (control-group). We compared groups for symptomatic intracranial hemorrhage (sICH, main outcome), any brain hemorrhage, good functional outcome (mRS 0–2 at 3 months), and death. The systematic review followed a predefined protocol (CRD42017060274), and odds ratio (OR) meta-analysis was implemented to compare groups.Results: Thirty-nine patients in dabigatran-reversal group and 300 matched controls were included. Reversal was associated with a non-significant increase in sICH (10.3% vs 6%, aOR = 1.32, 95% CI = 0.39–4.52), death (17.9% vs 10%, aOR = 0.77, 95% CI = 0.12–4.93) and good functional outcome (64.1% vs 52.8%, aOR = 1.41, 95% CI = 0.63–3.19). No hemorrhagic events or deaths were registered in no-reversal group (n = 12). Pooling data from 3 studies after systematic review (n = 1879), reversal carried a non-significant trend for sICH (OR = 1.53, 95% CI = 0.67–3.50), death (OR = 1.53, 95% CI = 0.73–3.24) and good functional outcome (OR = 2.46, 95% CI = 0.85–7.16).Discussion and conclusion: People treated with reperfusion strategies after dabigatran reversal with idarucizumab seem to have a marginal increase in the risk of sICH but comparable functional recovery to matched patients with stroke. Further studies are needed to define treatment cost-effectiveness and potential thresholds in plasma dabigatran concentration for reversal.
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- 2023
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34. Stroke network performance during the first COVID-19 pandemic stage: A meta-analysis based on stroke network models.
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Romoli, Michele, Eusebi, Paolo, Forlivesi, Stefano, Gentile, Mauro, Giammello, Fabrizio, Piccolo, Laura, Giannandrea, David, Vidale, Simone, Longoni, Marco, Paolucci, Matteo, Hsiao, Jessica, Sayles, Emily, Yeo, Leonard LL, Kristoffersen, Espen Saxhaug, Chamorro, Angel, Jiao, Liqun, Khatri, Pooja, Tsivgoulis, Georgios, Paciaroni, Maurizio, and Zini, Andrea
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COVID-19 pandemic ,NETWORK performance ,STROKE ,ISCHEMIC stroke ,COVID-19 ,ENDOVASCULAR surgery - Abstract
Background: The effect of the COVID pandemic on stroke network performance is unclear, particularly with consideration of drip&ship vs. mothership models. Aims: We systematically reviewed and meta-analyzed variations in stroke admissions, rate and timing of reperfusion treatments during the first wave COVID pandemic vs. the pre-pandemic timeframe depending on stroke network model adopted. Summary of findings: The systematic review followed registered protocol (PROSPERO-CRD42020211535), PRISMA and MOOSE guidelines. We searched MEDLINE, EMBASE, and CENTRAL until 9 October 2020 for studies reporting variations in ischemic stroke admissions, treatment rates, and timing in COVID (first wave) vs. control-period. Primary outcome was the weekly admission incidence rate ratio (IRR = admissions during COVID-period/admissions during control-period). Secondary outcomes were (i) changes in rate of reperfusion treatments and (ii) time metrics for pre- and in-hospital phase. Data were pooled using random-effects models, comparing mothership vs. drip&ship model. Overall, 29 studies were included in quantitative synthesis (n = 212,960). COVID-period was associated with a significant reduction in stroke admission rates (IRR = 0.69, 95%CI = 0.61–0.79), with higher relative presentation of large vessel occlusion (risk ratio (RR) = 1.62, 95% confidence interval (CI) = 1.24–2.12). Proportions of patients treated with endovascular treatment increased (RR = 1.14, 95%CI = 1.02–1.28). Intravenous thrombolysis decreased overall (IRR = 0.72, 95%CI = 0.54–0.96) but not in the mothership model (IRR = 0.81, 95%CI = 0.43–1.52). Onset-to-door time was longer for the drip&ship in COVID-period compared to the control-period (+32 min, 95%CI = 0–64). Door-to-scan was longer in COVID-period (+5 min, 95%CI = 2–7). Door-to-needle and door-to-groin were similar in COVID-period and control-period. Conclusions: Despite a 35% drop in stroke admissions during the first pandemic wave, proportions of patients receiving reperfusion and time-metrics were not inferior to control-period. Mothership preserved the weekly rate of intravenous thrombolysis and the onset-to-door timing to pre-pandemic standards. [ABSTRACT FROM AUTHOR]
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- 2021
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35. Sex differences in outcome after thrombectomy for acute ischemic stroke. A propensity score-matched study
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Casetta, Ilaria, Fainardi, Enrico, Pracucci, Giovanni, Saia, Valentina, Sallustio, Fabrizio, da Ros, Valerio, Nappini, Sergio, Nencini, Patrizia, Bigliardi, Guido, Vinci, Sergio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Zini, Andrea, Ruggiero, Maria, Longoni, Marco, Castellan, Lucio, Malfatto, Laura, Castellini, Paola, Cosottini, Mirco, Comai, Alessio, Franchini, Enrica, Lozupone, Emilio, Della Marca, Giacomo, Puglielli, Edoardo, Casalena, Alfonsina, Baracchini, Claudio, Savio, Daniele, Duc, Enrica, Ricciardi, Giuseppe, Cappellari, Manuel, Chiumarulo, Luigi, Petruzzellis, Marco, Cavallini, Anna, Cavasin, Nicola, Critelli, Adriana, Burdi, Nicola, Boero, Giovanni, Giorgianni, Andrea, Versino, Maurizio, Biraschi, Francesco, Nicolini, Ettore, Comelli, Simone, Melis, Maurizio, Padolecchia, Riccardo, Tassinari, Tiziana, Paolo Nuzzi, Nunzio, Marcheselli, Simona, Sacco, Simona, Invernizzi, Paolo, Gallesio, Ivan, Ferrandi, Delfina, Fancello, Maria, Valeria Saddi, Maria, Russo, Monia, Pischedda, Aldo, Baule, Antonio, Mannino, Marina, Florio, Francesco, Inchingolo, Vincenzo, Elena Flacco, Maria, Romano, Daniele, Silvagni, Umberto, Inzitari, Domenico, Mangiafico, Salvatore, and Toni, Danilo
- Abstract
Background and purpose We sought to investigate whether there are gender differences in clinical outcome after stroke due to large vessel occlusion (LVO) after mechanical thrombectomy (EVT) in a large population of real-world patients.Methods From the Italian Registry of Endovascular Thrombectomy, we extracted clinical and outcome data of patients treated for stroke due to large vessel occlusion. We compared clinical and safety outcomes in men and women who underwent EVT alone or in combination with intravenous thrombolysis (IVT) in the total population and in a Propensity Score matched set.Results Among 3422 patients included in the study, 1801 (52.6%) were women. Despite older age at onset (mean 72.4 vs 68.7; p< 0.001), and higher rate of atrial fibrillation (41.7% vs 28.6%; p< 0.001), women had higher probability of 3-month functional independence (adjusted odds ratio-adjOR 1.19; 95% CI 1.02–1.38), of complete recanalization (adjOR 1.25; 95% CI 1.09–1.44) and lower probability of death (adjOR 0.75; 95% CI 0.62–0.90). After propensity-score matching, a well-balanced cohort comprising 1150 men and 1150 women was analyzed, confirming the same results regarding functional outcome (3-month functional independence: OR 1.25; 95% CI 1.04–1.51), and complete recanalization (OR 1.29; 95% CI 1.09–1.53).Conclusions Subject to the limitations of a non-randomized comparison, women with stroke due to LVO treated with mechanical thrombectomy had a better chance to achieve complete recanalization, and 3-month functional independence than men. The results could be driven by women who underwent combined treatment.
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- 2022
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36. 18F Flutemetamol-PET Aided Classification of Cerebral Amyloid Angiopathy: A Multicenter Study.
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Romoli M, Marinoni G, Tagliabue L, Capozza A, Matteucci F, Mattone V, Longoni M, Cenni P, Ruggiero M, Rifino N, Canavero I, Boncoraglio G, Stanziano M, Bersano A, and Storti B
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- Humans, Male, Female, Aged, Middle Aged, Benzothiazoles, Aged, 80 and over, Intracranial Hemorrhages diagnostic imaging, Cerebral Amyloid Angiopathy diagnostic imaging, Cerebral Amyloid Angiopathy pathology, Cerebral Amyloid Angiopathy classification, Cerebral Amyloid Angiopathy complications, Positron-Emission Tomography methods, Magnetic Resonance Imaging, Aniline Compounds
- Abstract
Objectives: Cerebral amyloid angiopathy (CAA)-related features on neuroimaging often coexist with signs of arteriolosclerosis-small vessel disease on neuroimaging in people with intracranial hemorrhage (ICH). This study aimed at defining the value of amyloid pathology detected by
18F flutemetamol PET in reclassification and stratification of risk of bleeding in people with mixed CAA-arteriolosclerosis features., Methods: We included consecutive patients admitted to 2 institutions (2018-2023) with spontaneous symptomatic ICH, subarachnoid hemorrhage (SAH), transient focal neurologic episodes (TFNE), or cognitive impairment and MRI showing CAA hallmarks. All patients underwent brain magnetic resonance imaging (MRI) with susceptibility weighted imaging and18F flutemetamol PET imaging and were followed up for at least 1 year. We compared cases with CAA and arteriolosclerosis + CAA features and defined long-term outcomes (composite outcome including death, ICH, ischemic stroke, SAH, TFNE) depending on PET status (CAA/amyloid pathology vs arteriolosclerosis-predominant groups)., Results: Among 47 patients, according to PET and MRI imaging, 38 patients were reclassified in the CAA/amyloid pathology group and 9 in the arteriolosclerosis-predominant group, with similar cardiovascular risk factors but a significantly higher lobar microbleed burden for the former group. The CAA/amyloid pathology group had higher rates of composite outcome (43.9 vs 11.1 events per 100 patient-year; p = 0.039) and ICH (36.5 vs 5.6 events per 100 patient-years; p = 0.04) compared with the arteriolosclerosis-predominant group., Discussion:18F Flutemetamol PET imaging can help in reclassification of mixed arteriolosclerosis + CAA into CAA/amyloid pathology and arteriolosclerosis-predominant, with implications on long-term risk of recurrent events., Classification of Evidence: This study provides Class IV evidence that18F flutemetamol PET can distinguish between CAA + arteriolosclerosis and arteriolosclerosis-predominant pathology.- Published
- 2024
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37. Insight into Elderly ALS Patients in the Emilia Romagna Region: Epidemiological and Clinical Features of Late-Onset ALS in a Prospective, Population-Based Study.
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Gianferrari G, Martinelli I, Simonini C, Zucchi E, Fini N, Caputo M, Ghezzi A, Gessani A, Canali E, Casmiro M, De Massis P, Curro' Dossi M, De Pasqua S, Liguori R, Longoni M, Medici D, Morresi S, Patuelli A, Pugliatti M, Santangelo M, Sette E, Stragliati F, Terlizzi E, Vacchiano V, Zinno L, Ferro S, Amedei A, Filippini T, Vinceti M, Errals Group, and Mandrioli J
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Few studies have focused on elderly (>80 years) amyotrophic lateral sclerosis (ALS) patients, who represent a fragile subgroup generally not included in clinical trials and often neglected because they are more difficult to diagnose and manage. We analyzed the clinical and genetic features of very late-onset ALS patients through a prospective, population-based study in the Emilia Romagna Region of Italy. From 2009 to 2019, 222 (13.76%) out of 1613 patients in incident cases were over 80 years old at diagnosis, with a female predominance (F:M = 1.18). Elderly ALS patients represented 12.02% of patients before 2015 and 15.91% from 2015 onwards ( p = 0.024). This group presented with bulbar onset in 38.29% of cases and had worse clinical conditions at diagnosis compared to younger patients, with a lower average BMI (23.12 vs. 24.57 Kg/m
2 ), a higher progression rate (1.43 vs. 0.95 points/month), and a shorter length of survival (a median of 20.77 vs. 36 months). For this subgroup, genetic analyses have seldom been carried out (25% vs. 39.11%) and are generally negative. Finally, elderly patients underwent less frequent nutritional- and respiratory-supporting procedures, and multidisciplinary teams were less involved at follow-up, except for specialist palliative care. The genotypic and phenotypic features of elderly ALS patients could help identify the different environmental and genetic risk factors that determine the age at which disease onset occurs. Since multidisciplinary management can improve a patient's prognosis, it should be more extensively applied to this fragile group of patients.- Published
- 2023
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38. Epidemiological, Clinical and Genetic Features of ALS in the Last Decade: A Prospective Population-Based Study in the Emilia Romagna Region of Italy.
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Gianferrari G, Martinelli I, Zucchi E, Simonini C, Fini N, Vinceti M, Ferro S, Gessani A, Canali E, Valzania F, Sette E, Pugliatti M, Tugnoli V, Zinno L, Stano S, Santangelo M, De Pasqua S, Terlizzi E, Guidetti D, Medici D, Salvi F, Liguori R, Vacchiano V, Casmiro M, Querzani P, Currò Dossi M, Patuelli A, Morresi S, Longoni M, De Massis P, Rinaldi R, Borghi A, Errals Group, Amedei A, and Mandrioli J
- Abstract
Increased incidence rates of amyotrophic lateral sclerosis (ALS) have been recently reported across various Western countries, although geographic and temporal variations in terms of incidence, clinical features and genetics are not fully elucidated. This study aimed to describe demographic, clinical feature and genotype-phenotype correlations of ALS cases over the last decade in the Emilia Romagna Region (ERR). From 2009 to 2019, our prospective population-based registry of ALS in the ERR of Northern Italy recorded 1613 patients receiving a diagnosis of ALS. The age- and sex-adjusted incidence rate was 3.13/100,000 population (M/F ratio: 1.21). The mean age at onset was 67.01 years; women, bulbar and respiratory phenotypes were associated with an older age, while C9orf72-mutated patients were generally younger. After peaking at 70-75 years, incidence rates, among women only, showed a bimodal distribution with a second slight increase after reaching 90 years of age. Familial cases comprised 12%, of which one quarter could be attributed to an ALS-related mutation. More than 70% of C9orf72-expanded patients had a family history of ALS/fronto-temporal dementia (FTD); 22.58% of patients with FTD at diagnosis had C9orf72 expansion (OR 6.34, p = 0.004). In addition to a high ALS incidence suggesting exhaustiveness of case ascertainment, this study highlights interesting phenotype-genotype correlations in the ALS population of ERR.
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- 2022
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