Search

Alzheimer's disease (AD) is a neurodegenerative disease that involves multiple systems in the body. Numerous recent studies have revealed bidirectional crosstalk between the brain and bone, but the interaction between bone and brain in AD remains unclear. In this review, we summarize human studies of the association between bone and brain and provide an overview of their interactions and the underlying mechanisms in AD. We review the effects of AD on bone from the aspects of AD pathogenic proteins, AD risk genes, neurohormones, neuropeptides, neurotransmitters, brain‐derived extracellular vesicles (EVs), and the autonomic nervous system. Correspondingly, we elucidate the underlying mechanisms of the involvement of bone in the pathogenesis of AD, including bone‐derived hormones, bone marrow‐derived cells, bone‐derived EVs, and inflammation. On the basis of the crosstalk between bone and the brain, we propose potential strategies for the management of AD with the hope of offering novel perspectives on its prevention and treatment. Highlights: The pathogenesis of AD, along with its consequent changes in the brain, may involve disturbing bone homeostasis.Degenerative bone disorders may influence the progression of AD through a series of pathophysiological mechanisms.Therefore, relevant bone intervention strategies may be beneficial for the comprehensive management of AD. [ABSTRACT FROM AUTHOR]

Electrochemical reduction of CO2 (ECO2R) is gaining attention as a promising approach to store excess or intermittent electricity generated from renewable energies in the form of valuable chemicals such as CO, HCOOH, CH4, and so on. Selective ECO2R to CH4 is a challenging target because the rate-determining step of CH4 formation, namely CO* protonation, competes with hydrogen evolution reaction and the C–C coupling toward the production of longer-chain chemicals. Herein, a Cu-TiO2 composite catalyst consisting of CuOx clusters or Cu nanoparticles (CuNPs), which are isolated on the TiO2 grain surface, was synthesized using a one-pot solvothermal method and subsequent thermal treatment. The Cu-TiO2 catalyst exhibited high selectivity for CH4, and the ratio of FE for CH4 to total FE for all products in ECO2R reached 70%. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a neurodegenerative disease that involves multiple systems in the body. Numerous recent studies have revealed bidirectional crosstalk between the brain and bone, but the interaction between bone and brain in AD remains unclear. In this review, we summarize human studies of the association between bone and brain and provide an overview of their interactions and the underlying mechanisms in AD. We review the effects of AD on bone from the aspects of AD pathogenic proteins, AD risk genes, neurohormones, neuropeptides, neurotransmitters, brain-derived extracellular vesicles (EVs), and the autonomic nervous system. Correspondingly, we elucidate the underlying mechanisms of the involvement of bone in the pathogenesis of AD, including bone-derived hormones, bone marrow-derived cells, bone-derived EVs, and inflammation. On the basis of the crosstalk between bone and the brain, we propose potential strategies for the management of AD with the hope of offering novel perspectives on its prevention and treatment. HIGHLIGHTS: The pathogenesis of AD, along with its consequent changes in the brain, may involve disturbing bone homeostasis. Degenerative bone disorders may influence the progression of AD through a series of pathophysiological mechanisms. Therefore, relevant bone intervention strategies may be beneficial for the comprehensive management of AD., (© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)