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1. Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): an international, multicentric study

Author

Dayawansa, Sam, Dumot, Chloe, Mantziaris, Georgios, Xu, Zhiyuan, Pikis, Stylianos, Peker, Selcuk, Samanci, Yavuz, Ardor, Gokce D., Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Abdelkarim, Khaled, El-Shehaby, Amr M. N., Eldin, Reem M. Emad, Elazzazi, Ahmed H., Moreno, Nuria Martínez, Álvarez, Roberto Martínez, Liscak, Roman, May, Jaromir, Mathieu, David, Tourigny, Jean-Nicolas, Tripathi, Manjul, Rajput, Akshay, Kumar, Narendra, Kaur, Rupinder, Picozzi, Piero, Franzini, Andrea, Speckter, Herwin, Hernandez, Wenceslao, Brito, Anderson, Warnick, Ronald E., Alzate, Juan, Kondziolka, Douglas, Bowden, Greg N., Patel, Samir, and Sheehan, Jason P.

Published
2024
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2. Comparative analysis of stereotactic radiosurgery outcomes for supratentorial hemangioblastomas in von hippel-lindau disease and sporadic cases: A multi-center international study

Author

Tos, Salem M., Hajikarimloo, Bardia, Mantziaris, Georgios, Shaaban, Ahmed, Pham, Duy, Dayawansa, Sam, Wei, Zhishuo, McKendrick, Lindsay M., Niranjan, Ajay, Lunsford, L Dade, Peker, Selcuk, Samanci, Yavuz, Liscak, Roman, May, Jaromir, Mathieu, David, Picozzi, Piero, Franzini, Andrea, Warnick, Ronald E., Schoenhals, Jonathan E., Palmer, Joshua D., Xu, Zhiyuan, and Sheehan, Jason P.

Published
2024
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3. Epilepsy associated with cerebral cavernous malformations managed with stereotactic radiosurgery: an international, multicenter study

Author

Dumot, Chloe, Mantziaris, Georgios, Pikis, Stylianos, Dayawansa, Sam, Xu, Zhiyuan, Samanci, Yavuz, Ardor, Gokce D., Peker, Selcuk, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Abdel Karim, Khaled, El-Shehaby, Amr M. N., Eldin, Reem M. Emad, Elazzazi, Ahmed H., Moreno, Nuria Martínez, Álvarez, Roberto Martínez, Liscak, Roman, May, Jaromir, Mathieu, David, Tourigny, Jean-Nicolas, Tripathi, Manjul, Rajput, Akshay, Kumar, Narendra, Kaur, Rupinder, Picozzi, Piero, Franzini, Andrea, Speckter, Herwin, Hernandez, Wenceslao, Brito, Anderson, Warnick, Ronald E., Alzate, Juan, Kondziolka, Douglas, Bowden, Greg N., Patel, Samir, and Sheehan, Jason P.

Published
2023
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4. A retrospective comparison of active surveillance to stereotactic radiosurgery for the management of elderly patients with an incidental meningioma.

Author

Hallak, Hana, Mantziaris, Georgios, Pikis, Stylianos, Islim, Abdurrahman I., Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., El-Shehaby, Amr M. N., Abdelkarim, Khaled, Emad, Reem M., Mathieu, David, Lee, Cheng-Chia, Liscak, Roman, Alvarez, Roberto Martinez, Kondziolka, Douglas, Tripathi, Manjul, Speckter, Herwin, and Bowden, Greg N.

Subjects
OLDER patients, PROPENSITY score matching, ASYMPTOMATIC patients, WATCHFUL waiting, MENINGIOMA, STEREOTACTIC radiosurgery
Abstract

Introduction: Management for elderly patients (> 65yo) with incidental meningiomas remains unclear. This study aims to characterize the functional and tumor outcomes of expectant and stereotactic radiosurgery (SRS) management of asymptomatic meningioma elderly patients. Methods: Using retrospectively collected data from 14 centers, SRS outcomes were compared to radiographic and clinical observation of asymptomatic meningiomas in elderly patients following propensity score matching. Results: Following propensity score matching, 114 patients were in each cohort. Tumor control was achieved at 97.37% in the SRS cohort, and no meningioma growth was seen 71.93% of the observation cohorts (p < 0.01; OR 14.44 [95% CI 4.27–48.78]). New neurological deficits developed in 1.39% of the SRS cohort but in none of the patients managed conservatively. 3.5% of patients underwent resection in the active surveillance matched cohort compared to 0.9% of patients in the SRS cohort (p = 0.063; OR 0.135 [95% CI 0.163–1.117]). The all-cause mortality rate was almost half in the SRS group (9.65%) compared to the observation group (18.42%) (p = 0.06; OR 0.47 [95% CI.22–1.03]). Conclusion: SRS achieves superior radiological tumor control compared to surveillance but with a slightly increased the risk of new SRS-related neurological deficits in elderly patients with asymptomatic meningiomas. Although SRS reduces meningioma progression, the need for of an open neurosurgical procedure and mortality were not significantly reduced. Furthermore, mortality in the observation group was not directly related to the meningioma in any of the patients. [ABSTRACT FROM AUTHOR]

Published
2025
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5. Pleomorphic Xanthoastrocytoma: Multi-Institutional Evaluation of Stereotactic Radiosurgery.

Author

Düzkalir, Ali Haluk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Abdelkarim, Khaled, El-Shehaby, Amr M. N., Emad, Reem M., Martínez Moreno, Nuria, Martínez Álvarez, Roberto, Mathieu, David, Niranjan, Ajay, Lunsford, L. Dade, Wei, Zhishuo, Shanahan, Regan M., Liscak, Roman, May, Jaromir, Dono, Antonio, Blanco, Angel I., and Esquenazi, Yoshua

Published
2025
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6. Risk of new tumor, carotid stenosis, and stroke after stereotactic radiosurgery for pituitary tumor: A multicenter study of 2254 patients with imaging follow-up.

Author

Dumot, Chloe, Mantziaris, Georgios, Dayawansa, Sam, Brantley, Carson, Lee, Cheng-Chia, Yang, Huai-Che, Peker, Selcuk, Samanci, Yavuz, Mathieu, David, Tourigny, Jean-Nicolas, Moreno, Nuria Martinez, Alvarez, Roberto Martinez, Chytka, Thomas, Liscak, Roman, Speckter, Herwin, Lazo, Erwin, Brito, Anderson, Picozzi, Piero, Franzini, Andrea, and Alzate, Juan

Published
2024
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7. Local control and survival after stereotactic radiosurgery for colorectal cancer brain metastases: an international multicenter analysis

Author

Bin-Alamer, Othman, primary, Abou-Al-Shaar, Hussam, additional, Singh, Raj, additional, Mallela, Arka N., additional, Legarreta, Andrew, additional, Bowden, Greg, additional, Mathieu, David, additional, Perlow, Haley K., additional, Palmer, Joshua D., additional, Elhamdani, Shahed, additional, Shepard, Matthew, additional, Liang, Yun, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad Eldin, Reem, additional, Elazzazi, Ahmed Hesham, additional, Warnick, Ronald E., additional, Gozal, Yair M., additional, Daly, Megan, additional, McShane, Brendan, additional, Addis-Jackson, Marcel, additional, Karthikeyan, Gokul, additional, Smith, Sian, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Kaisman-Elbaz, Tehila, additional, Yang, Huai-che, additional, Hess, Judith, additional, Templeton, Kelsey, additional, Zhang, Xiaoran, additional, Wei, Zhishuo, additional, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Simonova, Gabriela, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Chiang, Veronica, additional, Kersh, Charles R., additional, Lee, Cheng-Chia, additional, Trifiletti, Daniel M., additional, Niranjan, Ajay, additional, Hadjipanayis, Constantinos G., additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2024
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8. Stereotactic Radiosurgery for WHO Grade 2 and 3 Oligodendroglioma: An International Multicenter Study

Author

Langlois, Anne-Marie, primary, Iorio-Morin, Christian, additional, Kallos, Justiss, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Park, David J., additional, Barnett, Gene H., additional, Liscak, Roman, additional, Simonova, Gabriela, additional, Sheehan, Jason P., additional, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Lee, Cheng-Chia, additional, Yang, Huai-Che, additional, Bowden, Gregory N., additional, and Mathieu, David, additional

Published
2024
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9. 499 Silent Corticotroph Staining Pituitary Neuroendocrine Tumors: Prognostic Significance in Radiosurgery

Author

Maragkos, Georgios A., primary, Mantziaris, Georgios, additional, Pikis, Stylianos, additional, Chytka, Tomas, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Bindal, Shray, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Kaur, Rupinder, additional, Tripathi, Manjul, additional, Pangal, Dhiraj J., additional, Strickland, Ben Allen, additional, Zada, Gabriel, additional, Langlois, Anne-Marie, additional, Mathieu, David, additional, Warnick, Ronald E., additional, Patel, Samir, additional, Minier, Zayda, additional, Speckter, Herwin, additional, Kondziolka, Douglas S., additional, Lee, Cheng-chia, additional, Lee Vance, Mary, additional, and Sheehan, Jason P., additional

Published
2024
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10. 220 Outcome Evaluation of Repeat Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations

Author

Mantziaris, Georgios, primary, Dumot, Chloe, additional, Liscak, Roman, additional, Lee, Cheng-Chia, additional, Lunsford, L. Dade, additional, Niranjan, Ajay, additional, Peker, Selcuk, additional, Mathieu, David, additional, Kondziolka, Douglas S., additional, Tripathi, Manjul, additional, Palmer, Joshua, additional, Zada, Gabriel, additional, Cifarelli, Christopher Paul, additional, Pikis, Stylianos, additional, Dayawansa, Sam, additional, and Sheehan, Jason P., additional

Published
2024
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11. Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): An International, Multicentric Study

Author

Dayawansa, Sam, primary, Dumot, Chloe, additional, Mantziaris, Georgios, additional, Xu, Zhiyuan, additional, Pikis, Stylianos, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Ardor, Gokce D, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M. N., additional, Eldin, Reem M Emad, additional, Elazzazi, Ahmed H, additional, Moreno, Nuria Martínez, additional, Álvarez, Roberto Martínez, additional, Liscak, Roman, additional, May, Jaromir, additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Rajput, Akshay, additional, Kumar, Narendra, additional, Kaur, Rupinder, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Brito, Anderson, additional, Warnick, Ronald E., additional, Alzate, Juan, additional, Kondziolka, Douglas, additional, Bowden, Greg N., additional, Patel, Samir, additional, and sheehan, jason, additional

Published
2024
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12. Long-term radiographic and endocrinological outcomes of stereotactic radiosurgery for recurrent or residual nonfunctioning pituitary adenomas

Author

Shaaban, Ahmed, primary, Dumot, Chloé, additional, Mantziaris, Georgios, additional, Dayawansa, Sam, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdel Karim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad Eldin, Reem M., additional, Ragab Abdelsalam, Ahmed, additional, Liscak, Roman, additional, May, Jaromir, additional, Mashiach, Elad, additional, De Nigris Vasconcellos, Fernando, additional, Bernstein, Kenneth, additional, Kondziolka, Douglas, additional, Speckter, Herwin, additional, Mota, Ruben, additional, Brito, Anderson, additional, Bindal, Shray K., additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Benjamin, Carolina Gesteira, additional, Almeida, Timoteo, additional, Mao, Jennifer Z., additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Palmer, Joshua David, additional, Matsui, Jennifer, additional, Crooks, Joseph, additional, Wegner, Rodney E., additional, Shepard, Matthew J., additional, and Sheehan, Jason P., additional

Published
2024
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13. Stereotactic radiosurgery for nonfunctioning pituitary tumor: A multicenter study of new pituitary hormone deficiency

Author

Dumot, Chloe, primary, Mantziaris, Georgios, additional, Dayawansa, Sam, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M, additional, Reda, Wael A, additional, Tawadros, Sameh R, additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M N, additional, Emad, Reem M, additional, Abdelsalam, Ahmed Ragab, additional, Liscak, Roman, additional, May, Jaromir, additional, Mashiach, Elad, additional, De Nigris Vasconcellos, Fernando, additional, Bernstein, Kenneth, additional, Kondziolka, Douglas, additional, Speckter, Herwin, additional, Mota, Ruben, additional, Brito, Anderson, additional, Bindal, Shray Kumar, additional, Niranjan, Ajay, additional, Lunsford, Dade L, additional, Benjamin, Carolina Gesteira, additional, Abrantes de Lacerda Almeida, Timoteo, additional, Mao, Jennifer, additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Palmer, Joshua David, additional, Matsui, Jennifer, additional, Crooks, Joe, additional, Wegner, Rodney E, additional, Shepard, Matthew J, additional, Vance, Mary Lee, additional, and Sheehan, Jason P, additional

Published
2023
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14. Clinical outcomes following stereotactic radiosurgery for cerebral cavernous malformations of the basal ganglia and thalamus

Author

Singh, Raj, primary, Dumot, Chloe, additional, Mantziaris, Georgios, additional, Dayawansa, Sam, additional, Xu, Zhiyuan, additional, Pikis, Stylianos, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Ardor, Gokce D., additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdel Karim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad Eldin, Reem M., additional, Sheehan, Darrah, additional, Sheehan, Kimball, additional, Elazzazi, Ahmed H., additional, Martínez Moreno, Nuria, additional, Martínez Álvarez, Roberto, additional, Liscak, Roman, additional, May, Jaromir, additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Rajput, Akshay, additional, Kumar, Narendra, additional, Kaur, Rupinder, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Brito, Anderson, additional, Warnick, Ronald E., additional, Alzate, Juan Diego, additional, Kondziolka, Douglas, additional, Bowden, Greg N., additional, Patel, Samir, additional, and Sheehan, Jason P., additional

Published
2023
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15. Effect of cerebral arteriovenous malformation location on outcomes of repeat, single-fraction stereotactic radiosurgery: a matched-cohort analysis

Author

Mantziaris, Georgios, primary, Pikis, Stylianos, additional, Dumot, Chloe, additional, Dayawansa, Sam, additional, Liscak, Roman, additional, May, Jaromir, additional, Lee, Cheng-Chia, additional, Yang, Huai-Che, additional, Martínez Moreno, Nuria, additional, Martinez Álvarez, Roberto, additional, Lunsford, L. Dade, additional, Niranjan, Ajay, additional, Wei, Zhishuo, additional, Srinivasan, Priyanka, additional, Tang, Lilly W., additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdel Karim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad Eldin, Reem M., additional, Elazzazi, Ahmed Hesham, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Padmanaban, Varun, additional, Jareczek, Francis J., additional, McInerney, James, additional, Cockroft, Kevin M., additional, Mathieu, David, additional, Aldakhil, Salman, additional, Alzate, Juan Diego, additional, Kondziolka, Douglas, additional, Tripathi, Manjul, additional, Palmer, Joshua D., additional, Upadhyay, Rituraj, additional, Lin, Michelle, additional, Zada, Gabriel, additional, Yu, Cheng, additional, Cifarelli, Christopher P., additional, Cifarelli, Daniel T., additional, Shaaban, Ahmed, additional, Xu, Zhiyuan, additional, and Sheehan, Jason P., additional

Published
2023
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16. Third Stereotactic Radiosurgery for Residual Arteriovenous Malformations: A Retrospective Multicenter Study.

Author

Pikis, Stylianos, Mantziaris, Georgios, Dumot, Chloe, Shaaban, Ahmed, Protopapa, Maria, Zhiyuan Xu, Niranjan, Ajay, Zhishuo Wei, Srinivasan, Priyanka, Tang, Lilly W., Liscak, Roman, May, Jaromir, Martinez Moreno, Nuria, Martinez Álvarez, Roberto, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., and Abdelkarim, Khaled

Published
2024
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18. Repeat stereotactic radiosurgery for persistent cerebral arteriovenous malformations in pediatric patients.

Author

Garcia, Gracie, Mantziaris, Georgios, Pikis, Stylianos, Dumot, Chloe, Lunsford, L. Dade, Niranjan, Ajay, Zhishuo Wei, Srinivasan, Priyanka, Tang, Lilly W., Liscak, Roman, May, Jaromir, Cheng-Chia Lee, Huai-Che Yang, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Karim, Khaled Abdel, and El-Shehaby, Amr M. N.

Published
2024
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19. Pediatric cerebral cavernous malformations and stereotactic radiosurgery: an analysis of 50 cases from a multicentric study.

Author

Mantziaris, Georgios, Dumot, Chloe, Pikis, Stylianos, Peker, Selcuk, Samanci, Yavuz, Ardor, Gokce D., Nabeel, Ahmed M., Reda, Wael A., Tawadros, Sameh R., Karim, Khaled Abdel, El-Shehaby, Amr M. N., Emad Eldin, Reem M., Elazzazi, Ahmed H., Sheehan, Darrah, Sheehan, Kimball, Martínez Moreno, Nuria, Martínez Álvarez, Roberto, Liscak, Roman, May, Jaromir, and Tripathi, Manjul

Published
2024
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20. Stereotactic radiosurgery for nonfunctioning pituitary tumor: A multicenter study of new pituitary hormone deficiency.

Author

Dumot, Chloe, Mantziaris, Georgios, Dayawansa, Sam, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M, Reda, Wael A, Tawadros, Sameh R, Abdelkarim, Khaled, El-Shehaby, Amr M N, Emad, Reem M, Abdelsalam, Ahmed Ragab, Liscak, Roman, May, Jaromir, Mashiach, Elad, Vasconcellos, Fernando De Nigris, Bernstein, Kenneth, Kondziolka, Douglas, Speckter, Herwin, and Mota, Ruben

Published
2024
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21. Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation: a multi-institutional, retrospective study

Author

Dumot, Chloe, primary, Mantziaris, Georgios, additional, Dayawansa, Sam, additional, Xu, Zhiyuan, additional, Pikis, Stylianos, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Ardor, Gokce D, additional, Nabeel, Ahmed M, additional, Reda, Wael A, additional, Tawadros, Sameh R, additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M N, additional, Emad Eldin, Reem M, additional, Elazzazi, Ahmed H, additional, Moreno, Nuria Martínez, additional, Martínez Álvarez, Roberto, additional, Liscak, Roman, additional, May, Jaromir, additional, Mathieu, David, additional, Tourigny, Jean-Nicolas, additional, Tripathi, Manjul, additional, Rajput, Akshay, additional, Kumar, Narendra, additional, Kaur, Rupinder, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Brito, Anderson, additional, Warnick, Ronald E, additional, Alzate, Juan, additional, Kondziolka, Douglas, additional, Bowden, Greg N, additional, Patel, Samir, additional, and Sheehan, Jason, additional

Published
2023
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22. Intratumoral Hemorrhage in Vestibular Schwannomas After Stereotactic Radiosurgery: Multi-Institutional Study

Author

Bin-Alamer, Othman, primary, Abou-Al-Shaar, Hussam, additional, Mallela, Arka N., additional, Kallos, Justiss A., additional, Deng, Hansen, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M. N., additional, Emad, Reem M., additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Mathieu, David, additional, Tripathi, Manjul, additional, Mantziaris, Georgios, additional, Mullapudi, Abhishek, additional, Urgosik, Dusan, additional, Liscak, Roman, additional, Bowden, Greg N., additional, Zaki, Peter, additional, Wegner, Rodney E., additional, Shepard, Matthew J., additional, Sheehan, Jason P., additional, Niranjan, Ajay, additional, Hadjipanayis, Constantinos G., additional, and Lunsford, L. Dade, additional

Published
2023
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23. Clinical and Imaging Outcomes After Trigeminal Schwannoma Radiosurgery: Results From a Multicenter, International Cohort Study

Author

Niranjan, Ajay, primary, Faramand, Andrew, additional, Raju, Sudesh S., additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Nabeel, Ahmed M., additional, Tawadros, Sameh R., additional, El-Shehaby, Amr M. N., additional, Abdelkarim, Khaled, additional, Emad, Reem M., additional, Reda, Wael A., additional, Álvarez, Roberto Martínez, additional, Moreno, Nuria E. Martínez, additional, Liscak, Roman, additional, May, Jaromir, additional, Mathieu, David, additional, Langlois, Anne-Marie, additional, Snyder, M. Harrison, additional, Shepard, Matthew J., additional, Sheehan, Jason, additional, Muhsen, Baha'eddin A., additional, Borghei-Razavi, Hamid, additional, Barnett, Gene, additional, Kondziolka, Douglas, additional, Golfinos, John G., additional, Attuati, Luca, additional, Picozzi, Piero, additional, McInerney, James, additional, Daggubati, Lekhaj Chand, additional, Warnick, Ronald E., additional, Feliciano, Caleb E., additional, Carro, Eric, additional, McCarthy, David, additional, Starke, Robert M., additional, Landy, Howard J., additional, Cifarelli, Christopher P., additional, Vargo, John A., additional, Flickinger, John, additional, and Lunsford, L. Dade, additional

Published
2023
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24. Silent Corticotroph Staining Pituitary Neuroendocrine Tumors: Prognostic Significance in Radiosurgery

Author

Maragkos, Georgios A., primary, Mantziaris, Georgios, additional, Pikis, Stylianos, additional, Chytka, Tomas, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Bindal, Shray K., additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Kaur, Rupinder, additional, Madan, Renu, additional, Tripathi, Manjul, additional, Pangal, Dhiraj J., additional, Strickland, Ben A., additional, Zada, Gabriel, additional, Langlois, Anne-Marie, additional, Mathieu, David, additional, Warnick, Ronald E., additional, Patel, Samir, additional, Minier, Zayda, additional, Speckter, Herwin, additional, Kondziolka, Douglas, additional, Lee, Cheng-chia, additional, Vance, Mary Lee, additional, and Sheehan, Jason P., additional

Published
2023
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25. Stereotactic radiosurgery for vestibular schwannoma in neurofibromatosis type 2: an international multicenter case series of response and malignant transformation risk

Author

Peker, Selçuk (ORCID 0000-0003-3057-3355 & YÖK ID 11480); Samancı, Mustafa Yavuz (ORCID 0000-0001-8952-6866 & YÖK ID 275252), Bin-Alamer, Othman; Faramand, Andrew; Alarifi, Norah A.; Wei, Zhishuo; Mallela, Arka N.; Lu, Victor M.; Nabeel, Ahmed M.; Reda, Wael A.; Tawadros, Sameh R.; Abdelkarim, Khaled; El-Shehaby, Amr M. N.; Emad, Reem M.; Lee, Cheng-chia; Yang, Huai-che; Delabar, Violaine; Mathieu, David; Tripathi, Manjul; Kearns, Kathryn Nicole; Bunevicius, Adomas; Sheehan, Jason P.; Chytka, Tomas; Liscak, Roman; Moreno, Nuria Martinez; Alvarez, Roberto Martinez; Grills, Inga S.; Parzen, Jacob S.; Cifarelli, Christopher P.; Rehman, Azeem A.; Speckter, Herwin; Niranjan, Ajay; Lunsford, L. Dade; Abou-Al-Shaar, Hussam, School of Medicine, Peker, Selçuk (ORCID 0000-0003-3057-3355 & YÖK ID 11480); Samancı, Mustafa Yavuz (ORCID 0000-0001-8952-6866 & YÖK ID 275252), Bin-Alamer, Othman; Faramand, Andrew; Alarifi, Norah A.; Wei, Zhishuo; Mallela, Arka N.; Lu, Victor M.; Nabeel, Ahmed M.; Reda, Wael A.; Tawadros, Sameh R.; Abdelkarim, Khaled; El-Shehaby, Amr M. N.; Emad, Reem M.; Lee, Cheng-chia; Yang, Huai-che; Delabar, Violaine; Mathieu, David; Tripathi, Manjul; Kearns, Kathryn Nicole; Bunevicius, Adomas; Sheehan, Jason P.; Chytka, Tomas; Liscak, Roman; Moreno, Nuria Martinez; Alvarez, Roberto Martinez; Grills, Inga S.; Parzen, Jacob S.; Cifarelli, Christopher P.; Rehman, Azeem A.; Speckter, Herwin; Niranjan, Ajay; Lunsford, L. Dade; Abou-Al-Shaar, Hussam, and School of Medicine

Abstract

BACKGROUND: Vestibular schwannomas (VSs) related to neurofibromatosis type 2 (NF2) are challenging tumors. The increasing use of stereotactic radiosurgery (SRS) necessitates further investigations of its role and safety. OBJECTIVE: To evaluate tumor control, freedom from additional treatment (FFAT), serviceable hearing preservation, and radiation-related risks of patients with NF2 after SRS for VS.METHODS: We performed a retrospective study of 267 patients with NF2 (328 VSs) who underwent single-session SRS at 12 centers participating in the International Radiosurgery Research Foundation. The median patient age was 31 years (IQR, 21-45 years), and 52% were male. RESULTS: A total of 328 tumors underwent SRS during a median follow-up time of 59 months (IQR, 23-112 months). At 10 and 15 years, the tumor control rates were 77% (95% CI: 69%-84%) and 52% (95% CI: 40%-64%), respectively, and the FFAT rate were 85% (95% CI: 79%-90%) and 75% (95% CI: 65%-86%), respectively. At 5 and 10 years, the serviceable hearing preservation rates were 64% (95% CI: 55%-75%) and 35% (95% CI: 25%-54%), respectively. In the multivariate analysis, age (hazards ratio: 1.03 [95% CI: 1.01-1.05]; P= .02) and bilateral VSs (hazards ratio: 4.56 [95% CI: 1.05-19.78]; P= .04) were predictors for serviceable hearing loss. Neither radiation-induced tumors nor malignant transformation were encountered in this cohort. CONCLUSION: Although the absolute volumetric tumor progression rate was 48% at 15 years, the rate of FFAT related to VS was 75% at 15 years after SRS. None of the patients with NF2-related VS developed a new radiation-related neoplasm or malignant transformation after SRS., NA

Published
2023

26. Facial Nerve Schwannoma Treatment with Stereotactic Radiosurgery (SRS) versus Resection followed by SRS: Outcomes and a Management Protocol.

Author

Dayawansa, Sam, Dumot, Chloe, Mantziaris, Georgios, Mehta, Gautam U., Lekovic, Gregory P., Kondziolka, Douglas, Mathieu, David, Reda, Wael A., Liscak, Roman, Cheng-chia, Lee, Kaufmann, Anthony M., Barnet, Gene, Trifiletti, Daniel M., Lunsford, L Dade, and Sheehan, Jason

Subjects
STEREOTACTIC radiosurgery, VESTIBULAR nerve, FACIAL nerve, RADIATION doses, CANCER invasiveness, SCHWANNOMAS
Abstract

Background Stereotactic radiosurgery (SRS) and resection are treatment options for patients with facial nerve schwannomas without mass effect. Objective This article evaluates outcomes of patients treated with SRS versus resection + SRS. Method We retrospectively compared 43 patients treated with SRS to 12 patients treated with resection + SRS. The primary study outcome was unfavorable combined endpoint, defined as worsening or new clinical symptoms, and/or tumor radiological progression. SRS (38.81 ± 5.3) and resection + SRS (67.14 ± 11.8) groups had similar clinical follow-ups. Results At the time of SRS, the tumor volumes of SRS (mean ± standard error; 1.83 ± 0.35 mL) and resection + SRS (2.51 ± 0.75 mL) groups were similar. SRS (12.15 ± 0.08 Gy) and resection + SRS (12.16 ± 0.14 Gy) groups received similar radiation doses. SRS group (42/43, 98%) had better local tumor control than the resection + SRS group (10/12, 83%, p = 0.04). Most of SRS (32/43, 74%) and resection + SRS (10/12, 83%) group patients reached a favorable combined endpoint following SRS (p = 0.52). Considering surgical associated side effects, only 2/10 patients of the resection + SRS group reached a favorable endpoint (p < 0.001). Patients of SRS group, who are > 34 years old (p = 0.02), have larger tumors (> 4 mL, 0.04), internal auditory canal (IAC) segment tumor involvement (p = 0.01) were more likely to reach an unfavorable endpoint. Resection + SRS group patients did not show such a difference. Conclusion While resection is still needed for larger tumors, SRS offers better clinical and radiological outcomes compared to resection followed by SRS for facial schwannomas. Younger age, smaller tumors, and non-IAC situated tumors are factors that portend a favorable outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Clinical and Imaging Outcomes After Trigeminal Schwannoma Radiosurgery: Results From a Multicenter, International Cohort Study.

Author

Niranjan, Ajay, Faramand, Andrew, Raju, Sudesh S., Cheng-chia Lee, Huai-che Yang, Nabeel, Ahmed M., Tawadros, Sameh R., El-Shehaby, Amr M. N., Abdelkarim, Khaled, Emad, Reem M., Reda, Wael A., Álvarez, Roberto Martínez, Martínez Moreno, Nuria E., Liscak, Roman, May, Jaromir, Mathieu, David, Langlois, Anne-Marie, Snyder, M. Harrison, Shepard, Matthew J., and Sheehan, Jason

Published
2024
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28. Adjuvant Stereotactic Radiosurgery With or Without Postresection Fractionated Radiation Therapy for the Management of Clival Chordomas in Adults: An International Multicenter Case Series

Author

Bin-Alamer, Othman, primary, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Abdulbaki, Arif, additional, Mallela, Arka N., additional, Lu, Victor M., additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, El-Shehaby, Amr M. N., additional, Abdelkarim, Khaled, additional, Emad Eldin, Reem M., additional, Sheehan, Darrah, additional, Sheehan, Kimball, additional, Liscak, Roman, additional, Chytka, Tomas, additional, Tripathi, Manjul, additional, Madan, Renu, additional, Speckter, Herwin, additional, Hernández, Wenceslao, additional, Barnett, Gene H., additional, Hori, Yusuke S., additional, Dabhi, Nisha, additional, Aldakhil, Salman, additional, Mathieu, David, additional, Kondziolka, Douglas, additional, Bernstein, Kenneth, additional, Wei, Zhishuo, additional, Niranjan, Ajay, additional, Kersh, Charles R., additional, Lunsford, L. Dade, additional, Sheehan, Jason P., additional, and Abou-Al-Shaar, Hussam, additional

Published
2023
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29. 477 Stereotactic Radiosurgery With Versus Without Prior Onyx Embolization for Brain Arteriovenous Malformations

Author

Chen, Ching-Jen, primary, Ding, Dale, additional, Lee, Cheng-chia, additional, Kearns, Kathryn, additional, Pomeraniec, Isaac Jonathan, additional, Cifarelli, Christopher Paul, additional, Liscak, Roman, additional, May, Jaromir, additional, Williams, Brian Jeremy, additional, Ironside, Natasha, additional, Burke, Rebecca M., additional, Warnick, Ronald E., additional, Trifiletti, Daniel M., additional, Mathieu, David, additional, Kondziolka, Douglas, additional, Feliciano, Caleb E., additional, Rodriguez-Mercado, Rafael, additional, Cockroft, Kevin M., additional, Simon, Scott Douglas, additional, Lee, John Y.K., additional, and Sheehan, Jason P., additional

Published
2023
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30. Local Control and Survival Outcomes After Stereotactic Radiosurgery for Brain Metastases From Gastrointestinal Primaries: An International Multicenter Analysis

Author

Singh, Raj, primary, Bowden, Greg, additional, Mathieu, David, additional, Perlow, Haley K., additional, Palmer, Joshua D., additional, Elhamdani, Shahed, additional, Shepard, Matthew, additional, Liang, Yun, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R, additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M.N., additional, Emad, Reem M, additional, Elazzazi, Ahmed Hesham, additional, Warnick, Ronald E., additional, Gozal, Yair M., additional, Daly, Megan, additional, McShane, Brendan, additional, Addis-Jackson, Marcel, additional, Karthikeyan, Gokul, additional, Smith, Sian, additional, Picozzi, Piero, additional, Franzini, Andrea, additional, Kaisman-Elbaz, Tehila, additional, Yang, Huai-che, additional, Wei, Zhishuo, additional, Legarreta, Andrew, additional, Hess, Judith, additional, Templeton, Kelsey, additional, Pikis, Stylianos, additional, Mantziaris, Georgios, additional, Simonova, Gabriela, additional, Liscak, Roman, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Chiang, Veronica, additional, Niranjan, Ajay, additional, Kersh, Charles R., additional, Lee, Cheng-Chia, additional, Trifiletti, Daniel M., additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2023
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31. Stereotactic Radiosurgery for Vestibular Schwannoma in Neurofibromatosis Type 2: An International Multicenter Case Series of Response and Malignant Transformation Risk

Author

Bin-Alamer, Othman, primary, Faramand, Andrew, additional, Alarifi, Norah A., additional, Wei, Zhishuo, additional, Mallela, Arka N., additional, Lu, Victor M., additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M.N., additional, Emad, Reem M., additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Delabar, Violaine, additional, Mathieu, David, additional, Tripathi, Manjul, additional, Kearns, Kathryn Nicole, additional, Bunevicius, Adomas, additional, Sheehan, Jason P., additional, Chytka, Tomas, additional, Liscak, Roman, additional, Moreno, Nuria Martínez, additional, Álvarez, Roberto Martínez, additional, Grills, Inga S., additional, Parzen, Jacob S., additional, Cifarelli, Christopher P., additional, Rehman, Azeem A., additional, Speckter, Herwin, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, and Abou-Al-Shaar, Hussam, additional

Published
2023
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32. Effects of Neuroanatomic Structural Distances on Pituitary Function After Stereotactic Radiosurgery: A Multicenter Study

Author

Ironside, Natasha, primary, Chen, Ching-Jen, additional, Xu, Zhiyuan, additional, Schlesinger, David, additional, Lee Vance, Mary, additional, Hong, Gregory K., additional, Jane, John A., additional, Patel, Samir, additional, Bindal, Shray K., additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Liscak, Roman, additional, Chytka, Thomas, additional, Jezkova, Jana, additional, Saifi, Omran, additional, Trifiletti, Daniel M., additional, Berger, Assaf, additional, Alzate, Juan, additional, Bernstein, Kenneth, additional, Kondziolka, Douglas, additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Lazo, Erwin, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Zacharia, Brad E., additional, Mau, Christine, additional, Wegner, Rodney E., additional, Shepard, Matthew J., additional, Mathieu, David, additional, Maillet, Michel, additional, and Sheehan, Jason P., additional

Published
2023
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35. Stereotactic Radiosurgery for Intraventricular Metastases: A Multicenter Study

Author

Mantziaris, Georgios, primary, Pikis, Stylianos, additional, Xu, Zhiyuan, additional, Mullen, Reed, additional, Alzate, Juan, additional, Bernstein, Kenneth, additional, Kondziolka, Douglas, additional, Wei, Zhishuo, additional, Niranjan, Ajay, additional, Lunsford, L. Dade, additional, Liscak, Roman, additional, May, Jaromir, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Coupé, François-Louis, additional, Mathieu, David, additional, Sheehan, Kimball, additional, Sheehan, Darrah, additional, Palmer, Joshua D., additional, Perlow, Haley K., additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Peterson, Jennifer, additional, Trifiletti, Daniel M., additional, Shepard, Matthew J., additional, Elhamdani, Shahed, additional, Wegner, Rodney E., additional, Speckter, Herwin, additional, Hernandez, Wenceslao, additional, Warnick, Ronald E., additional, and Sheehan, Jason, additional

Published
2022
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36. Facial Nerve Schwannoma Treatment with Stereotactic Radiosurgery (SRS) versus Resection followed by SRS: Outcomes and a Management Protocol

Author

Dayawansa, Sam, additional, Dumot, Chloe, additional, Mantziaris, Georgios, additional, Mehta, Gautam U., additional, Lekovic, Gregory P., additional, Kondziolka, Douglas, additional, Mathieu, David, additional, Reda, Wael A., additional, Liscak, Roman, additional, Cheng-chia, Lee, additional, Kaufmann, Anthony M., additional, Barnet, Gene, additional, Trifiletti, Daniel M., additional, Lunsford, L Dade, additional, and Sheehan, Jason, additional

Published
2022
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37. Chronic Encapsulated Expanding Hematomas After Stereotactic Radiosurgery for Intracranial Arteriovenous Malformations: An International Multicenter Case Series

Author

Abou-Al-Shaar, Hussam, primary, Patel, Aneek, additional, Mallela, Arka N., additional, Bin-Alamer, Othman, additional, Niranjan, Ajay, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Liscak, Roman, additional, May, Jaromir, additional, Kumar, Jeyan Sathia, additional, Sheehan, Jason P., additional, and Lunsford, L. Dade, additional

Published
2022
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38. Stereotactic radiosurgery for intracranial chordomas: an international multiinstitutional study

Author

Pikis, Stylianos, primary, Mantziaris, Georgios, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, El-Shehaby, Amr M. N., additional, Abdelkarim, Khaled, additional, Eldin, Reem M. Emad, additional, Sheehan, Darrah, additional, Sheehan, Kimball, additional, Liscak, Roman, additional, Chytka, Tomas, additional, Tripathi, Manjul, additional, Madan, Renu, additional, Speckter, Herwin, additional, Hernández, Wenceslao, additional, Barnett, Gene H., additional, Hori, Yusuke S., additional, Dabhi, Nisha, additional, Aldakhil, Salman, additional, Mathieu, David, additional, Kondziolka, Douglas, additional, Bernstein, Kenneth, additional, Wei, Zhishuo, additional, Niranjan, Ajay, additional, Kersh, Charles R., additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2022
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40. Stereotactic Radiosurgery Compared With Active Surveillance for Asymptomatic, Parafalcine, and Parasagittal Meningiomas: A Matched Cohort Analysis From the IMPASSE Study

Author

Pikis, Stylianos, primary, Mantziaris, Georgios, additional, Bunevicius, Adomas, additional, Islim, Abdurrahman I., additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, El-Shehaby, Amr M. N., additional, Abdelkarim, Khaled, additional, Emad, Reem M., additional, Delabar, Violaine, additional, Mathieu, David, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Liscak, Roman, additional, May, Jaromir, additional, Alvarez, Roberto Martinez, additional, Patel, Dev N., additional, Kondziolka, Douglas, additional, Bernstein, Kenneth, additional, Moreno, Nuria Martinez, additional, Tripathi, Manjul, additional, Speckter, Herwin, additional, Albert, Camilo, additional, Bowden, Greg N., additional, Benveniste, Ronald J., additional, Lunsford, L. Dade, additional, Jenkinson, Michael D., additional, and Sheehan, Jason, additional

Published
2022
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41. Comparison of Active Surveillance to Stereotactic Radiosurgery for the Management of Patients with an Incidental Frontobasal Meningioma—A Sub-Analysis of the IMPASSE Study

Author

Islim, Abdurrahman I., primary, Mantziaris, Georgios, additional, Pikis, Stylianos, additional, Chen, Ching-Jen, additional, Bunevicius, Adomas, additional, Peker, Selçuk, additional, Samanci, Yavuz, additional, Nabeel, Ahmed M., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, El-Shehaby, Amr M. N., additional, Abdelkarim, Khaled, additional, Emad, Reem M., additional, Delabar, Violaine, additional, Mathieu, David, additional, Lee, Cheng-Chia, additional, Yang, Huai-Che, additional, Liscak, Roman, additional, May, Jaromir, additional, Alvarez, Roberto Martinez, additional, Moreno, Nuria Martinez, additional, Tripathi, Manjul, additional, Kondziolka, Douglas, additional, Speckter, Herwin, additional, Albert, Camilo, additional, Bowden, Greg N., additional, Benveniste, Ronald J., additional, Lunsford, Lawrence Dade, additional, Sheehan, Jason P., additional, and Jenkinson, Michael D., additional

Published
2022
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42. 153 An International Multicenter Matched Cohort Analysis of Incidental Meningioma Progression During Active Surveillance or After Stereotactic Radiosurgery: The IMPASSE Study

Author

Sheehan, Jason P., primary, Pikis, Stylianos, additional, Islim, Abdurrahman, additional, Mathieu, David, additional, Liscak, Roman, additional, Tripathi, Manjul, additional, Kondziolka, Douglas S., additional, Bowden, Greg N., additional, Lunsford, L. Dade, additional, and Jenkinson, Michael D., additional

Published
2022
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43. Reirradiation With Stereotactic Radiosurgery After Local or Marginal Recurrence of Brain Metastases From Previous Radiosurgery

Author

Kowalchuk, Roman O., primary, Niranjan, Ajay, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Liscak, Roman, additional, Guseynova, Khumar, additional, Tripathi, Manjul, additional, Kumar, Narendra, additional, Peker, Selcuk, additional, Samanci, Yavuz, additional, Hess, Judith, additional, Chiang, Veronica, additional, Iorio-Morin, Christian, additional, Mathieu, David, additional, Pikis, Stylianos, additional, Wei, Zhishuo, additional, Lunsford, L. Dade, additional, Trifiletti, Daniel M., additional, and Sheehan, Jason P., additional

Published
2022
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44. Dose to neuroanatomical structures surrounding pituitary adenomas and the effect of stereotactic radiosurgery on neuroendocrine function: an international multicenter study

Author

Pomeraniec, I. Jonathan, primary, Xu, Zhiyuan, additional, Lee, Cheng-Chia, additional, Yang, Huai-Che, additional, Chytka, Tomas, additional, Liscak, Roman, additional, Martinez-Alvarez, Roberto, additional, Martinez-Moreno, Nuria, additional, Attuati, Luca, additional, Picozzi, Piero, additional, Kondziolka, Douglas, additional, Mureb, Monica, additional, Bernstein, Kenneth, additional, Mathieu, David, additional, Maillet, Michel, additional, Ogino, Akiyoshi, additional, Long, Hao, additional, Kano, Hideyuki, additional, Lunsford, L. Dade, additional, Zacharia, Brad E., additional, Mau, Christine, additional, Tuanquin, Leonard C., additional, Cifarelli, Christopher, additional, Arsanious, David, additional, Hack, Joshua, additional, Warnick, Ronald E., additional, Strickland, Ben A., additional, Zada, Gabriel, additional, Chang, Eric L., additional, Speckter, Herwin, additional, Patel, Samir, additional, Ding, Dale, additional, Sheehan, Darrah, additional, Sheehan, Kimball, additional, Kvint, Svetlana, additional, Buch, Love Y., additional, Haber, Alexander R., additional, Shteinhart, Jacob, additional, Vance, Mary Lee, additional, and Sheehan, Jason P., additional

Published
2022
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45. 300 Stereotactic Radiosurgery With Versus Without Embolization for Brain Arteriovenous Malformations

Author

Chen, Ching-Jen, primary, Ding, Dale, additional, Lee, Cheng-chia, additional, Kearns, Kathryn, additional, Pomeraniec, Isaac J., additional, Ironside, Natasha, additional, Kondziolka, Douglas S., additional, Trifiletti, Daniel M., additional, Liscak, Roman, additional, Cockroft, Kevin M., additional, Lee, John Y. K., additional, and Sheehan, Jason P., additional

Published
2022
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46. Stereotactic Radiosurgery for Intraventricular Metastases: A Multicenter Study.

Author

Mantziaris, Georgios, Pikis, Stylianos, Xu, Zhiyuan, Mullen, Reed, Alzate, Juan, Bernstein, Kenneth, Kondziolka, Douglas, Wei, Zhishuo, Niranjan, Ajay, Lunsford, L. Dade, Liscak, Roman, May, Jaromir, Lee, Cheng-chia, Yang, Huai-che, Coupé, François-Louis, Mathieu, David, Sheehan, Kimball, Sheehan, Darrah, Palmer, Joshua D., and Perlow, Haley K.

Published
2023
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48. Stereotactic Radiosurgery for World Health Organization Grade 2 and 3 Oligodendroglioma: An International Multicenter Study

Author

Langlois, Anne-Marie, Iorio-Morin, Christian, Kallos, Justiss, Niranjan, Ajay, Lunsford, L. Dade, Peker, Selcuk, Samanci, Yavuz, Park, David J., Barnett, Gene H., Liscak, Roman, Simonova, Gabriela, Pikis, Stylianos, Mantziaris, Georgios, Sheehan, Jason, Lee, Cheng-chia, Yang, Huai-che, Bowden, Greg N., and Mathieu, David

Published
2025
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49. Skull Base Meningiomas in Patients with Neurofibromatosis Type 2: An International Multicenter Study Evaluating Stereotactic Radiosurgery.

Author

Ruiz-Garcia, Henry, Trifiletti, Daniel M., Mohammed, Nasser, Hung, Yi-Chieh, Xu, Zhiyuan, Chytka, Tomas, Liscak, Roman, Tripathi, Manjul, Arsanious, David, Cifarelli, Christopher P., Caceres, Marco Perez, Mathieu, David, Speckter, Herwin, Mehta, Gautam U., Lekovic, Gregory P., and Sheehan, Jason P.

Subjects
NEUROFIBROMATOSIS 2, SKULL base, STEREOTACTIC radiosurgery, STEREOTAXIC techniques, RADIOSURGERY, CEREBRAL arteriovenous malformations, PROGRESSION-free survival
Abstract

Objective  Meningiomas are the second most common tumors in neurofibromatosis type 2 (NF-2). Microsurgery is challenging in NF-2 patients presenting with skull base meningiomas due to the intrinsic risks and need for multiple interventions over time. We analyzed treatment outcomes and complications after primary Gamma Knife radiosurgery (GKRS) to delineate its role in the management of these tumors. Methods  An international multicenter retrospective study approved by the International Radiosurgery Research Foundation was performed. NF-2 patients with at least one growing and/or symptomatic skull base meningioma and 6-month follow-up after primary GKRS were included. Clinical and radiosurgical parameters were recorded for analysis. Results  In total, 22 NF-2 patients with 54 skull base meningiomas receiving GKRS as primary treatment met inclusion criteria. Median age at GKRS was 38 years (10–79 years). Most lesions were located in the posterior fossa (55.6%). Actuarial progression free survival (PFS) rates were 98.1% at 2 years and 90.0% at 5 and 10 years. The median follow-up time after initial GKRS was 5.0 years (0.6–25.5 years). Tumor volume at GKRS was a predictor of tumor control. Lesions >5.5 cc presented higher chances to progress after radiosurgery (p  = 0.043). Three patients (13.64%) developed adverse radiation effects. No malignant transformation or death due to meningioma or radiosurgery was reported. Conclusions  GKRS is effective and safe in the management of skull base meningiomas in NF-2 patients. Tumor volume deserve greater relevance during clinical decision-making regarding the most appropriate time to treat. GKRS offers a minimally invasive approach of particular interest in this specific group of patients. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Hemorrhage and Recurrence of Obliterated Brain Arteriovenous Malformations Treated With Stereotactic Radiosurgery.

Author

Chen, Ching-Jen, Ding, Dale, Kumar, Jeyan S., Kearns, Kathryn N., Ironside, Natasha, Yang, Huai-Che, Ogino, Akiyoshi, Kano, Hideyuki, Liscak, Roman, May, Jaromir, Williams, Brian J., Gigliotti, Michael J., Cockroft, Kevin, McInerney, James, Simon, Scott, Lee, Cheng-Chia, Sheehan, Jason P., and International Radiosurgery Research Foundation

Published
2022
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