Author: "Lin, G. L." / Publication Year Range: Last 3 years - Searchworks@Jio Institute Digital Library Search Results

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30 results on '"Lin, G. L."'

1. Measurement of Electron Antineutrino Oscillation Amplitude and Frequency via Neutron Capture on Hydrogen at Daya Bay

Author: Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. -C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Experiment
Abstract: This Letter reports the first measurement of the oscillation amplitude and frequency of reactor antineutrinos at Daya Bay via neutron capture on hydrogen using 1958 days of data. With over 3.6 million signal candidates, an optimized candidate selection, improved treatment of backgrounds and efficiencies, refined energy calibration, and an energy response model for the capture-on-hydrogen sensitive region, the relative $\overline{\nu}_{e}$ rates and energy spectra variation among the near and far detectors gives $\mathrm{sin}^22\theta_{13} = 0.0759_{-0.0049}^{+0.0050}$ and $\Delta m^2_{32} = (2.72^{+0.14}_{-0.15})\times10^{-3}$ eV$^2$ assuming the normal neutrino mass ordering, and $\Delta m^2_{32} = (-2.83^{+0.15}_{-0.14})\times10^{-3}$ eV$^2$ for the inverted neutrino mass ordering. This estimate of $\sin^2 2\theta_{13}$ is consistent with and essentially independent from the one obtained using the capture-on-gadolinium sample at Daya Bay. The combination of these two results yields $\mathrm{sin}^22\theta_{13}= 0.0833\pm0.0022$, which represents an 8% relative improvement in precision regarding the Daya Bay full 3158-day capture-on-gadolinium result.
Published: 2024

2. Search for a sub-eV sterile neutrino using Daya Bay's full dataset

Author: An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Experiment
Abstract: This Letter presents results of a search for the mixing of a sub-eV sterile neutrino with three active neutrinos based on the full data sample of the Daya Bay Reactor Neutrino Experiment, collected during 3158 days of detector operation, which contains $5.55 \times 10^{6}$ reactor \anue candidates identified as inverse beta-decay interactions followed by neutron-capture on gadolinium. The analysis benefits from a doubling of the statistics of our previous result and from improvements of several important systematic uncertainties. No significant oscillation due to mixing of a sub-eV sterile neutrino with active neutrinos was found. Exclusion limits are set by both Feldman-Cousins and CLs methods. Light sterile neutrino mixing with $\sin^2 2\theta_{14} \gtrsim 0.01$ can be excluded at 95\% confidence level in the region of $0.01$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.1 $ eV$^2$. This result represents the world-leading constraints in the region of $2 \times 10^{-4}$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.2 $ eV$^2$., Comment: 7 pages, 4 figures, 1 table
Published: 2024

3. First measurement of the yield of $^8$He isotopes produced in liquid scintillator by cosmic-ray muons at Daya Bay

Author: Daya Bay Collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: Nuclear Experiment, High Energy Physics - Experiment
Abstract: Daya Bay presents the first measurement of cosmogenic $^8$He isotope production in liquid scintillator, using an innovative method for identifying cascade decays of $^8$He and its child isotope, $^8$Li. We also measure the production yield of $^9$Li isotopes using well-established methodology. The results, in units of 10$^{-8}\mu^{-1}$g$^{-1}$cm$^{2}$, are 0.307$\pm$0.042, 0.341$\pm$0.040, and 0.546$\pm$0.076 for $^8$He, and 6.73$\pm$0.73, 6.75$\pm$0.70, and 13.74$\pm$0.82 for $^9$Li at average muon energies of 63.9~GeV, 64.7~GeV, and 143.0~GeV, respectively. The measured production rate of $^8$He isotopes is more than an order of magnitude lower than any other measurement of cosmogenic isotope production. It replaces the results of previous attempts to determine the ratio of $^8$He to $^9$Li production that yielded a wide range of limits from 0 to 30\%. The results provide future liquid-scintillator-based experiments with improved ability to predict cosmogenic backgrounds.
Published: 2024

4. Charged-current non-standard neutrino interactions at Daya Bay

Author: Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract: The full data set of the Daya Bay reactor neutrino experiment is used to probe the effect of the charged current non-standard interactions (CC-NSI) on neutrino oscillation experiments. Two different approaches are applied and constraints on the corresponding CC-NSI parameters are obtained with the neutrino flux taken from the Huber-Mueller model with a $5\%$ uncertainty. For the quantum mechanics-based approach (QM-NSI), the constraints on the CC-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ are extracted with and without the assumption that the effects of the new physics are the same in the production and detection processes, respectively. The approach based on the weak effective field theory (WEFT-NSI) deals with four types of CC-NSI represented by the parameters $[\varepsilon_{X}]_{e\alpha}$. For both approaches, the results for the CC-NSI parameters are shown for cases with various fixed values of the CC-NSI and the Dirac CP-violating phases, and when they are allowed to vary freely. We find that constraints on the QM-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ from the Daya Bay experiment alone can reach the order $\mathcal{O}(0.01)$ for the former and $\mathcal{O}(0.1)$ for the latter, while for WEFT-NSI parameters $[\varepsilon_{X}]_{e\alpha}$, we obtain $\mathcal{O}(0.1)$ for both cases., Comment: 25 pages, 16 figures, 6 tables; 36 pages, format changed, references added
Published: 2024

5. Charged-current non-standard neutrino interactions at Daya Bay

Author: An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y.-C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Morales Reveco, C., Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W.-H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Published: 2024
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6. Precision measurement of reactor antineutrino oscillation at kilometer-scale baselines by Daya Bay

Author: Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, Y. Y., Ding, X. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Pan, H. -R., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Experiment
Abstract: We present a new determination of the smallest neutrino mixing angle ${\theta}_{13}$ and the mass-squared difference ${\Delta}{\rm m}^{2}_{32}$ using a final sample of $5.55 \times 10^{6}$ inverse beta-decay (IBD) candidates with the final-state neutron captured on gadolinium. This sample was selected from the complete data set obtained by the Daya Bay reactor neutrino experiment in 3158 days of operation. Compared to the previous Daya Bay results, selection of IBD candidates has been optimized, energy calibration refined, and treatment of backgrounds further improved. The resulting oscillation parameters are ${\rm sin}^{2}2{\theta}_{13} = 0.0851 \pm 0.0024$, ${\Delta}{\rm m}^{2}_{32} = (2.466 \pm 0.060) \times 10^{-3}{\rm eV}^{2}$ for the normal mass ordering or ${\Delta}{\rm m}^{2}_{32} = -(2.571 \pm 0.060) \times 10^{-3} {\rm eV}^{2}$ for the inverted mass ordering., Comment: 7 pages, 3 figures, 1 table, 10 supplementary files
Published: 2022

7. First measurement of high-energy reactor antineutrinos at Daya Bay

Author: Daya Bay collaboration, An, F. P., Balantekin, A. B., Band, H. R., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, S. M., Chen, Y., Chen, Y. X., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dove, J., Dvorak, M., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Higuera, A., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, J. J., Li, Q. J., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Lu, C., Lu, H. Q., Lu, J. S., Luk, K. B., Ma, X. B., Ma, X. Y., Ma, Y. Q., Marshall, C., Caicedo, D. A. Martinez, McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Ochoa-Ricoux, J. P., Olshevskiy, A., Pan, H. -R., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, F. L., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. W., Zhang, Q. M., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: This Letter reports the first measurement of high-energy reactor antineutrinos at Daya Bay, with nearly 9000 inverse beta decay candidates in the prompt energy region of 8-12~MeV observed over 1958 days of data collection. A multivariate analysis is used to separate 2500 signal events from background statistically. The hypothesis of no reactor antineutrinos with neutrino energy above 10~MeV is rejected with a significance of 6.2 standard deviations. A 29\% antineutrino flux deficit in the prompt energy region of 8-11~MeV is observed compared to a recent model prediction. We provide the unfolded antineutrino spectrum above 7 MeV as a data-based reference for other experiments. This result provides the first direct observation of the production of antineutrinos from several high-$Q_{\beta}$ isotopes in commercial reactors., Comment: 7 pages, 4 figures, accepted by Physical Review Letters
Published: 2022
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8. Preliminary observation of tungsten-impurity suppression using on-axis ECRH by X-ray crystal spectroscopy in EAST

Author: Lin, Z. C., primary, Zhang, H. M., additional, Wang, F. D., additional, Bae, C., additional, Fu, J., additional, Shen, Y. C., additional, Dai, S. Y., additional, Lu, D. A., additional, Jin, Y. F., additional, He, L., additional, Wang, M. R., additional, Lin, G. L., additional, Ye, K. X., additional, Wang, S. X., additional, Zhao, H. L., additional, and Lyu, B., additional
Published: 2023
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9. High Energy Physics Opportunities Using Reactor Antineutrinos

Author: Awe, C., Barbeau, P. S., Haghighat, A., Huber, P., Li, S. C., Link, J. M., Mascolino, V., Subedi, T., Walkup, K., Aguilar-Arevalo, A., Bertou, X., Bonifazi, C., Cancelo, G., Cervantes-Vergara, B. A., Chavez, C., D Olivo, J. C., Egea, J. M., Dos Anjos, J. C., Estrada, J., Neto, A. R. F., Fernandez-Moroni, G., Foguel, A., Ford, R., Gasanego, J., Gollo, V., Izraelevitch, F., Kilminster, B., Lima, Jr H. P., Makler, M., Mendes, L. H., Molina, J., Mota, P., Nasteva, I., Paolini, E., Romero, C., Sarkis, Y., Haro, M. S., Soto, A., Stalder, D., Tiffenberg, J., Torres, C., Lindner, M., An, F. P., Balantekin, A. B., Band, H. R., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, S. M., Chen, Y., Chen, Y. X., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dove, J., Dvořák, M., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Higuera, A., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, X. T., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, S., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Lu, C., Lu, H. Q., Lu, J. S., Luk, K. B., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., Martinez Caicedo, D. A., Mcdonald, K. T., Mckeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Ochoa-Ricoux, J. P., Olshevskiy, A., Pan, H. -R, Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H, Tull, C. E., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, F. L., Wu, Q., Wenjie Wu, Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. W., Zhang, Q. M., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhou, L., Zhuang, H. L., Zou, J. H., Abusleme, A., Adam, T., Ahmad, S., Ahmed, R., Aiello, S., An, G. P., An, Q., Andronico, G., Anfimov, N., Antonelli, V., Antoshkina, T., Asavapibhop, B., André, J. P. A. M., Auguste, D., Babic, A., Baldini, W., Barresi, A., Baussan, E., Bellato, M., Bergnoli, A., Bernieri, E., Birkenfeld, T., Blin, S., Blum, D., Bolshakova, A., Bongrand, M., Bordereau, C., Breton, D., Brigatti, A., Brugnera, R., Bruno, R., Budano, A., Buesken, M., Buscemi, M., Busto, Jose, Butorov, I., Cabrera, A., Cai, H., Cai, X., Cai, Y. K., Cai, Z. Y., Cammi, A., Campeny, A., Cao, C. Y., Caruso, R., Cerna, C., Chakaberia, I., Chen, P. P., Chen, P. A., Chen, S., Chen, X., Chen, Y. W., Chen, Z., Cheng, Y., Chiesa, D., Chimenti, P., Chukanov, A., Chuvashova, A., Claverie, G., Clementi, C., Clerbaux, B., Di Lorenzo, S., Corti, D., Costa, S., Corso, F. D., La Taille, C., Deng, J., Deng, Z., Deng, Z. Y., Depnering, W., Diaz, M., Ding, X. F., Dirgantara, B., Dmitrievsky, S., Donchenko, G., Dong, J. M., Dornic, D., Doroshkevich, E., Dracos, M., Druillole, F., Du, S. X., Dusini, S., Dvorak, M., Enqvist, T., Enzmann, H., Fabbri, A., Fajt, L., Fan, D. H., Fan, L., Fang, C., Fang, J., Fang, W. X., Fargetta, M., Fatkina, A., Fedoseev, D., Fekete, V., Feng, L. C., Feng, Q. C., Formozov, A., Fournier, A., Gan, H. N., Gao, F., Garfagnini, A., Göttel, A., Genster, C., Giammarchi, M., Giaz, A., Giudice, N., Gong, G., Gorchakov, O., Gornushkin, Y., Grassi, M., Grewing, C., Gromov, V., Gu, M., Gu, X., Gu, Y., Guan, M. Y., Guardone, N., Gul, M., Guo, C., Guo, W. L., Hackspacher, P., Hagner, C., Han, R., Han, Y., Hassan, M., He, W., Heinz, T., Hellmuth, P., Herrera, R., Hong, D. J., Hou, S. J., Hsiung, Y., Hu, H., Hu, J., Hu, S. Y., Huang, C. H., Huang, G. H., Huang, Q. H., Huang, W. H., Huang, X., Huang, Y. B., Hui, J. Q., Huo, L., Huo, W., Huss, C., Hussain, S., Insolia, A., Ioannisian, A., Isocrate, R., Ji, X. Z., Jia, H. H., Jia, J. J., Jian, S. Y., Jiang, D., Jiang, X. S., Jin, R. Y., Jing, X. P., Jollet, C., Joutsenvaara, J., Jungthawan, S., Kalousis, L., Kampmann, P., Karagounis, M., Kazarian, N., Khan, A., Khan, W., Khosonthongkee, K., Kinz, P., Korablev, D., Kouzakov, K., Krasnoperov, A., Krumshteyn, Z., Kruth, A., Kutovskiy, N., Kuusiniemi, P., Lachenmaier, T., Landini, C., Leblanc, S., Lebrin, V., Lefevre, F., Lei, R., Leung, J., Li, C., Li, D., Li, H., Li, J., Li, K. J., Li, M. Z., Li, M., Li, N., Li, R. H., Li, S. F., Li, S. J., Li, T., Li, W. G., Li, X. M., Li, X. L., Li, Y., Li, Z., Li, Z. Y., Liang, J. J., Liebau, D., Limphirat, A., Limpijumnong, S., Lin, S. X., Lin, T., Lippi, I., Liu, F., Liu, H. D., Liu, H. B., Liu, H. J., Liu, H. T., Liu, H., Liu, M., Liu, Q., Liu, R. X., Liu, S. Y., Liu, S. B., Liu, S. L., Liu, X. W., Liu, X., Liu, Y., Lokhov, A., Lombardi, P., Lombardo, C., Loo, K., Lu, J. B., Lu, J. G., Lu, S. X., Lu, X. X., Lubsandorzhiev, B., Lubsandorzhiev, S., Ludhova, L., Luo, F. J., Luo, G., Luo, P. W., Luo, S., Luo, W. M., Lyashuk, V., Ma, Q. M., Ma, S., Maalmi, J., Malyshkin, Y., Mantovani, F., Manzali, F., Mao, X., Mao, Y. J., Mari, S. M., Marini, F., Marium, S., Martellini, C., Martin-Chassard, G., Martini, A., Mayilyan, D., Müller, A., Mednieks, I., Meregaglia, A., Meroni, E., Meyhöfer, D., Mezzetto, M., Miller, J., Miramonti, L., Monforte, S., Montini, P., Montuschi, M., Morozov, N., Muhammad, A., Muralidharan, P., Nastasi, M., Naumov, D. V., Nemchenok, I., Ning, F. P., Ning, Z., Nunokawa, H., Oberauer, L., Orestano, D., Ortica, F., Pan, H. R., Paoloni, A., Parkalian, N., Parmeggiano, S., Payupol, T., Pei, Y., Pelliccia, N., Peng, A., Peng, H., Perrot, F., Petitjean, P. A., Petrucci, F., Piñeres Rico, L. F., Pilarczyk, O., Popov, A., Poussot, P., Pratumwan, W., Previtali, E., Qi, F., Qian, S., Qian, X. H., Qiao, H., Qin, Z. H., Qiu, S. K., Rajput, M., Ranucci, G., Re, A., Rebber, H., Rebii, A., Ren, B., Rezinko, T., Ricci, B., Robens, M., Roche, M., Rodphai, N., Romani, A., Roth, C., Ruan, X., Rujirawat, S., Rybnikov, A., Sadovsky, A., Saggese, P., Salamanna, G., Sanfilippo, S., Sangka, A., Sanguansak, N., Sawangwit, U., Sawatzki, J., Sawy, F., Schever, M., Schuler, J., Schwab, C., Schweizer, K., Selivanov, D., Selyunin, A., Serafini, A., Settanta, G., Settimo, M., Shao, Z., Sharov, V., Shi, J., Shutov, V., Sidorenkov, A., Simkovic, F., Sirignano, C., Siripak, J., Sisti, M., Slupecki, M., Smirnov, M., Smirnov, O., Sogo-Bezerra, T., Songwadhana, J., Soonthornthum, B., Sotnikov, A., Sramek, O., Sreethawong, W., Stahl, A., Stanco, L., Stankevich, K., Stefanik, D., Steiger, H., Steinmann, J., Sterr, T., Stock, M. R., Strati, V., Studenikin, A., Sun, G. X., Sun, S. F., Sun, X. L., Sun, Y. J., Sun, Y. Z., Suwonjandee, N., Szelezniak, M., Tang, J., Tang, Q., Tang, X., Tietzsch, A., Tkachev, I., Triossi, A., Troni, G., Trzaska, W., Tuve, C., Ushakov, N., Waasen, S., Boom, J. Vanden, Vanroyen, G., Vassilopoulos, N., Vedin, V., Verde, G., Vialkov, M., Viaud, B., Volpe, C., Voronin, D., Votano, L., Walker, P., Wang, C., Wang, E., Wang, G., Wang, K. Y., Wang, L., Wang, M. F., Wang, S. G., Wang, W. S., Wang, X. Y., Wang, Y. G., Wang, Y. Q., Wang, Z. Y., Waqas, M., Watcharangkool, A., Wei, W., Wei, Y. D., Wiebusch, C., Wong, S. C. F., Wonsak, B., Wu, D., Wu, W. J., Wu, Z., Wurm, M., Wurtz, J., Wysotzki, C., Xi, Y. F., Xie, Y. G., Xu, B., Xu, C., Xu, D. L., Xu, F. R., Xu, H. K., Xu, J., Xu, M. H., Xu, Y., Yan, B. J., Yan, T., Yan, W. Q., Yan, X. B., Yan, Y. P., Yang, A. B., Yang, H., Yang, J., Yang, X. Y., Yang, Y., Yang, Y. F., Yasin, Z., Ye, J. X., Ye, Z. P., Yegin, U., Yermia, F., Yi, P. H., Yin, X. W., You, Z. Y., Yu, B. X., Yu, C. Y., Yu, C. X., Yu, M., Yu, X. H., Yuan, C. Z., Yuan, Y., Yuan, Z. X., Yuan, Z. Y., Zafar, N., Zambanini, A., Zeng, T. X., Zeng, Y. D., Zhang, G. Q., Zhang, H. Q., Zhang, J., Zhang, J. B., Zhang, P., Zhang, S., Zhang, T., Zhang, X. M., Zhang, Y., Zhang, Y. H., Zhang, Y. P., Zhao, F. Y., Zhao, R., Zhao, S. J., Zhao, T. C., Zheng, D. Q., Zheng, H., Zheng, M. S., Zheng, Y. H., Zhong, W. R., Zhou, J., Zhou, N., Zhou, S., Zhou, X., Zhu, J., Zhu, K. J., Zhuang, B., Zong, L., Rasco, B. C., Han, B. Y., Jeon, E. J., Jeong, Y., Jo, H. S., Kim, D. K., Kim, J. Y., Kim, J. G., Kim, Y. D., Ko, Y. J., Lee, H. M., Lee, M. H., Moon, C. S., Oh, Y. M., Park, H. K., Park, K. S., Seo, S. H., Siyeon, K., Sun, G. M., Yoon, Y. S., Yu, I., Borusinski, M. J., Dorrill, R., Druetzler, A., Learned, J., Li, V., Markoff, D., Maricic, J., Matsuno, S., Mumm, H. P., Nishimura, K., Irani, A., Pitt, M., Rasco, C., Thibodeau, B., Varner, G., Vogelaar, B., Wright, T., Andriamirado, M., Bass, C. D., Bergeron, D. E., Berish, D., Bowden, N. S., Brodsky, J. P., Bryan, C. D., Carr, R., Classen, T., Conant, A. J., Deichert, G., Dolinski, M. J., Erickson, A., Foust, B. T., Gaison, J. K., Galindo-Uribarri, A., Gilbert, C. E., Grant, C., Hackett, B. T., Hansell, A. B., Ji, X., Jones, D. C., Kyzylova, O., Lane, C. E., Larosa, J., Lu, X., Mendenhall, M. P., Meyer, A. M., Milincic, R., Mitchell, I., Mueller, P. E., Nave, C., Neilson, R., Nikkel, J. A., Norcini, D., Nour, S., Palomino, J. L., Pushin, D. A., Romero-Romero, E., Surukuchi, P. T., Tyra, M. A., Varner, R. L., Venegas-Vargas, D., Weatherly, P. B., White, C., Wilhelmi, J., Woolverton, A., Zhang, A., Zhang, X., Choi, J. H., Jang, H. I., Jang, J. S., Jeon, S. H., Joo, K. K., Ju, K., Jung, D. E., Kim, J. H., Kim, S. B., Kim, S. Y., Kim, W., Kwon, E., Lee, D. H., Lee, H. G., Lim, I. T., Moon, D. H., Pac, M. Y., Seo, H., Seo, J. W., Shin, C. D., Yang, B. S., Yoo, J., Yoon, S. G., Yeo, I. S., Chang, C., Bergé, L., Broniatowski, A., Dumoulin, L., Giuliani, A., Chapellier, M., Marcillac, P., Marnieros, S., Olivieri, E., Poda, D., Calvo, M., Goupy, J., Monfardini, A., Arnaud, Q., Augier, C., Billard, J., Cazes, A., Colas, J., Filippini, J., Gascon, J., Jesus, M., Lattaud, H., Juillard, A., Salagnac, T., Soldner, T., Lubashevskiy, A., Yakushev, E., Rozov, S., Lamblin, J., Mom, B., Stutz, A., Formaggio, J. A., Mayer, D. W., Johnston, J., Harrington, P., Heine, S., Sibille, V., Chen, R., Figueroa-Feliciano, E., Ziqing, H., Hertel, S., Patel, P., Pinckney, D., Serafin, A., Shilcusky, A., Decheine, N., Palladino, K., Weber, S., Hirjibehedin, C., Akindele, O. A., Carman, L., Dazeley, S., Ford, M., Jovanovic, I., Sutanto, F., Zaitseva, N., Beaumont, W., Binet, S., Bolognino, I., Borg, J., Buridon, V., Chanal, H., Coupé, B., Crochet, P., Cussans, D., Roeck, A., Durand, D., Fallot, M., Galbinski, D., Gallego, S., Giot, L., Guillon, B., Henaff, D., Hayashida, S., Hosseini, B., Kalcheva, S., Lehaut, G., Michiels, I., Monteil, S., Newbold, D., Roy, N., Ryckbosch, D., Sfar, H. Rejeb, Simard, L., Vacheret, A., Vandierendonck, G., Dyck, S., Remortel, N., Vercaemer, S., Verstraeten, M., Weber, A., Yeresko, M., Bonhomme, A., Buck, C., Del Amo Sanchez, P., El Atmani, I., Labit, L., Letourneau, A., Lhuillier, D., Licciardi, M., Materna, T., Pessard, H., Rogly, R., Savu, V., Schoppmann, S., Vialat, M., Algora, A., Beloeuvre, A., Estienne, M., Kean, R., Porta, A., Tain, J. L., Sidelnik, I., Anderson, T., Askins, M., Bagdasarian, Z., Baldoni, A., Barna, A., Benson, T., Bergevin, M., Bernstein, A., Birrittella, B., Bogetic, S., Boissevain, J., Borusinki, J., Boyd, S., Brooks, T., Budsworth, Mat, Burns, J., Calle, M., Camilo, C., Carroll, A., Coleman, J., Collins, R., Connor, C., Cowen, D., Crow, B., Curry, J., Dalnoki-Veress, F., Danielson, D., Diwan, M., Dixon, S., Drakopoulou, L., Duron, J., Dye, S., Fargher, S., Fienberg, A., Fischer, V., Foster, R., Frankiewicz, Kat, Gamble, T., Gooding, D., Gokhale, S., Gregorio, R., Gribble, J., Griskevich, J., Hadley, D., He, J., Healey, K., Hecla, J., Holt, G., Jabbari, C., Jewkes, K., Kaiser, R., Keenan, M., Keener, P., Kneale, Liz, Kudryavtsev, V., Kunkle, P., Litchfield, P., Liu, X. Ran, Lynch, G., Malek, M., Marr-Laundrie, P., Masic, B., Mauger, C., Mccauley, N., Metelko, C., Mills, R., Mitra, A., Muheim, F., Mullen, A., Murphy, A., Needham, M., Neights, E., Ogren, K., Orebi Gann, G., Oxborough, L., Paling, S., Papatyi, A., Paulos, B., Pershing, T., Pickard, L., Quillin, S., Resoro, R., Richards, B., Sabarots, L., Scarff, A., Schnellbach, Yan-Jie, Scovell, P., Seitz, B., Shea, O., Shebalin, V., Smith, G., Smy, M., Song, H., Spooner, N., Stanton, C., Stone, O., Svoboda, R., Szoldos, S., Thompson, L., Thomson, F., Toth, C., Vagins, M., Berg, Rick, Ventura, S., Walsh, B., Webster, J., Weiss, M., Westphal, D., Wetstein, M., Wilson, T., Wilson, S., Wolcott, S., Wright, M., Berryman, J. M., Collar, J. I., Erlandson, A., Gariazzo, S., Garzelli, M. V., Giunti, C., Goldblum, B. L., Hayes, A., Hedges, S., Mariani, C., Minic, D., Mougeot, X., Naim, D., Newby, J., Ni, K., O Donnell, T., Ozturk, S., Périssé, L., Pestes, R., Sonzogni, A. A., Tabrizi, Z., Vivier, M., Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Neutrino de Champagne Ardenne (LNCA - UMS 3263), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Cryogénie (NEEL - Cryo), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Hélium : du fondamental aux applications (NEEL - HELFA), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut Laue-Langevin (ILL), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département de Physique Nucléaire (ex SPhN) (DPHN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CHANDLER, CONNIE, CONUS, Daya Bay, JUNO, MTAS, NEOS, NuLat, PROSPECT, RENO, Ricochet, ROADSTR Near-Field Working Group, SoLid, Stereo, Valencia-Nantes TAGS, vIOLETA, WATCHMAN, and HEP, INSPIRE
Subjects: High Energy Physics - Experiment (hep-ex), [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], hep-ex, neutrino: energy spectrum, antineutrino: nuclear reactor, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], FOS: Physical sciences, neutrino: oscillation, neutrino: nuclear reactor, Particle Physics - Experiment, neutrino: flux, High Energy Physics - Experiment
Abstract: Nuclear reactors are uniquely powerful, abundant, and flavor-pure sources of antineutrinos that continue to play a vital role in the US neutrino physics program. The US reactor antineutrino physics community is a diverse interest group encompassing many detection technologies and many particle physics topics, including Standard Model and short-baseline oscillations, BSM physics searches, and reactor flux and spectrum modeling. The community's aims offer strong complimentary with numerous aspects of the wider US neutrino program and have direct relevance to most of the topical sub-groups composing the Snowmass 2021 Neutrino Frontier. Reactor neutrino experiments also have a direct societal impact and have become a strong workforce and technology development pipeline for DOE National Laboratories and universities. This white paper, prepared as a submission to the Snowmass 2021 community organizing exercise, will survey the state of the reactor antineutrino physics field and summarize the ways in which current and future reactor antineutrino experiments can play a critical role in advancing the field of particle physics in the next decade., Contribution to Snowmass 2021
Published: 2022

10. First Measurement of High-Energy Reactor Antineutrinos at Daya Bay

Author: An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Pan, H.-R., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Morales Reveco, C., Rosero, R., Roskovec, B., Ruan, X. C., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W.-H., Tull, C. E., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, General Physics and Astronomy, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment, High Energy Physics - Experiment, Physics::Geophysics
Abstract: This Letter reports the first measurement of high-energy reactor antineutrinos at Daya Bay, with nearly 9000 inverse beta decay candidates in the prompt energy region of 8-12~MeV observed over 1958 days of data collection. A multivariate analysis is used to separate 2500 signal events from background statistically. The hypothesis of no reactor antineutrinos with neutrino energy above 10~MeV is rejected with a significance of 6.2 standard deviations. A 29\% antineutrino flux deficit in the prompt energy region of 8-11~MeV is observed compared to a recent model prediction. We provide the unfolded antineutrino spectrum above 7 MeV as a data-based reference for other experiments. This result provides the first direct observation of the production of antineutrinos from several high-$Q_{\beta}$ isotopes in commercial reactors., Comment: 7 pages, 4 figures, accepted by Physical Review Letters
Published: 2022

11. Joint Determination of Reactor Antineutrino Spectra from ²³⁵U and ²³⁹Pu Fission by Daya Bay and PROSPECT

Author: An, F. P., Andriamirado, M., Balantekin, A. B., Band, H. R., Bass, C. D., Bergeron, D. E., Berish, D., Bishai, M., Blyth, S., Bowden, N. S., Bryan, C. D., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, S. M., Chen, Y., Chen, Y. X., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Classen, T., Conant, A. J., Cummings, J. P., Dalager, O., Deichert, G., Delgado, A., Deng, F. S., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolinski, M. J., Dolzhikov, D., Dove, J., Dvořák, M., Dwyer, D. A., Erickson, A., Foust, B. T., Gaison, J. K., Galindo-Uribarri, A., Gallo, J. P., Gilbert, C. E., Gonchar, M., Gong, G. H., Gong, H., Grassi, M., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Hans, S., Hansell, A. B., He, M., Heeger, K. M., Heffron, B., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Koblanski, J., Jaffe, D. E., Jayakumar, S., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D. C., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Kyzylova, O., Lane, C. E., Langford, T. J., LaRosa, J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Lu, X., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Maricic, J., Marshall, C., McDonald, K. T., McKeown, R. D., Mendenhall, M. P., Meng, Y., Meyer, A. M., Milincic, R., Mueller, P. E., Mumm, H. P., Napolitano, J., Naumov, D., Naumova, E., Neilson, R., Nguyen, T. M. T., Nikkel, J. A., Nour, S., Ochoa-Ricoux, J. P., Olshevskiy, A., Palomino, J. L., Pan, H.-R., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Pushin, D. A., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Morales Reveco, C., Rosero, R., Roskovec, B., Ruan, X. C., Searles, M., Steiner, H., Sun, J. L., Surukuchi, P. T., Tmej, T., Treskov, K., Tse, W.-H., Tull, C. E., Tyra, M. A., Varner, R. L., Venegas-Vargas, D., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y., Wang, Y. F., Wang, Z., Wang, Z. M., Weatherly, P. B., Wei, H. Y., Wei, L. H., Wen, L. J., Whisnant, K., White, C., Wilhelmi, J., Wong, H. L. H., Woolverton, A., Worcester, E., Wu, D. R., Wu, F. L., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Abstract: A joint determination of the reactor antineutrino spectra resulting from the fission of ²³⁵U and ²³⁹Pu has been carried out by the Daya Bay and PROSPECT Collaborations. This Letter reports the level of consistency of ²³⁵U spectrum measurements from the two experiments and presents new results from a joint analysis of both data sets. The measurements are found to be consistent. The combined analysis reduces the degeneracy between the dominant ²³⁵U and ²³⁹Pu isotopes and improves the uncertainty of the ²³⁵U spectral shape to about 3%. The ²³⁵U and ²³⁹Pu antineutrino energy spectra are unfolded from the jointly deconvolved reactor spectra using the Wiener-SVD unfolding method, providing a data-based reference for other reactor antineutrino experiments and other applications. This is the first measurement of the ²³⁵U and ²³⁹Pu spectra based on the combination of experiments at low- and highly enriched uranium reactors.
Published: 2022

12. Publisher Correction: Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus

Author: Peter J. M. Openshaw, Jeroen Aerssens, Daniel H. O'Connor, Harish Nair, Federico Martinón-Torres, Christopher C Butler, Simon B. Drysdale, Matthew D. Snape, Tanya Golubchik, David Bonsall, Rory Bowden, Deniz Öner, Anthony Brown, G MacIntyre-Cockett, M A Ansari, E Mellado-Gomez, Andrew J. Pollard, M de Cesare, Louis Bont, Lin G-L., and Commission of the European Communities
Subjects: Male, GeneralLiterature_INTRODUCTORYANDSURVEY, Science, Mutation, Missense, General Physics and Astronomy, Respiratory Syncytial Virus Infections, Biology, Virus Replication, Viral infection, General Biochemistry, Genetics and Molecular Biology, Virus, Viral Proteins, Viral genetics, Humans, Viral evolution, Aged, Science & Technology, Multidisciplinary, Host (biology), Genetic Variation, Infant, General Chemistry, Publisher Correction, Antigenic Variation, Virology, Multidisciplinary Sciences, Respiratory Syncytial Virus, Human, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Science & Technology - Other Topics, Female, RESCEU Investigators
Abstract: Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children globally, but little is known about within-host RSV diversity. Here, we characterised within-host RSV populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017-2020. RSV-B had lower consensus diversity than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B consensus sequences had an amino acid alteration (K68N) in the fusion (F) protein, which has been associated with reduced susceptibility to nirsevimab (MEDI8897), a novel RSV monoclonal antibody under development. In addition, several minor variants were identified in the antigenic sites of the F protein, one of which may confer resistance to palivizumab, the only licensed RSV monoclonal antibody. The differences in within-host virus populations emphasise the importance of monitoring for vaccine efficacy and may help to explain the different prevalences of monoclonal antibody-escape mutants between the two subgroups.
Published: 2021

13. [Impacts of participation in surgical clinical trial on safety and survival outcomes in patients with right-sided colon cancer].

Author: Zhang HQ, Wang GQ, Wu B, Lin GL, Qiu HZ, Niu BZ, Lu JY, Xu L, Sun XY, Zhang GN, and Xiao Y
Abstract: Objective: To explore the impact on safety and prognosis in patients with right-sided colon cancer participating in surgical clinical research. Methods: This retrospective cohort study utilized data from a randomized controlled trial (RELARC study) conducted by the colorectal surgery group at Peking Union Medical College Hospital in which laparoscopic complete mesocolic excision (CME) was compared with D2 radical resection for the management of right-sided colon cancer. The eligibility criteria were age 18-75 years, biopsy-proven colon adenocarcinoma, tumor located between the cecum and right 1/3 of the transverse colon, enhanced chest, abdomen, and pelvic CT scans suggesting tumor stage T2-T4N0M0 or TanyN+ M0, and having undergone radical surgical treatment from January 2016 to December 2019. Exclusion factors included multiple primary colorectal cancers, preoperative stage T1N0 or enlarged central lymph nodes, tumor involving surrounding organs requiring their resection, definite distant metastasis or otherwise unable to undergo R0 resection, history of any other malignant tumors within previous 5 years, intestinal obstruction, perforation, or gastrointestinal bleeding requiring emergency surgery, and assessed as unsuitable for laparoscopic surgery. Patients who had participated in the RELARC study were included in the RELARC group, whereas those who met the inclusion criteria but refused to participate in the RELAEC study were included in the control group. The main indicators studied were the patient's baseline data, surgery and perioperative conditions, pathological characteristics, adjuvant treatment, and postoperative follow-up (including average frequency of follow-up within the first 3 years) and survival (including 3-year disease-free survival rate (DFS) and 3-year overall survival rate (OS). Differences in these indicators between the RELARC and control groups were compared. Results: The study cohort comprised 290 patients, 173 in the RELARC group (RELARC-CME group, 82; RELARC-D2 group, 91) and 117 in the control group (CME control group, 72; D2 control group, 45). There was a significantly higher proportion of overweight patients (BMI ≥24 kg/m 2 ) in the RELARC-CME than in the CME control group (67.1% [55/82] vs. 33.3% [24/72], χ 2 =17.469, P <0.001). There were no other statistically significant differences in baseline characteristics (all P >0.05). No significant disparities were found between the CME and D2 groups in terms of operation duration, intraoperative blood loss, rate of conversion to open surgery, combined organ resection, intraoperative blood transfusion, or intraoperative complications (all P >0.05). There was a trend toward Clavien-Dindo grade II or higher postoperative complications in the RELARC-CME group (24.4% [20/82]) than in the CME control group (18.1% [13/72]); however, this difference was not statistically significant (χ 2 =0.914, P =0.339). Similarly, the difference in this rate did not differ significantly between the RELARC-D2 group (25.3% [23/91]) and D2 control group (24.4% [11/45], χ 2 =0.011, P =0.916). The median duration of postoperative follow-up was significantly shorter in the RELARC groups than in the corresponding control groups. Specifically, the median duration of follow-up was 4.5 (4.5, 4.5) months in the RELARC-CME and 7.2 (6.0, 9.0) months in the CME control group ( Z =-10.608, P <0.001). Similarly, the median duration of follow-up was 4.5 (4.5, 4.5) months in the RELARC-D2 group as opposed to 8.3 (6.6, 9.0) months in the D2 control group ( Z =-10.595, P <0.001). The 3-year DFS rate (91.5%) and OS rate (96.3%) tended to be higher in the RELARC-CME group than in the CME control group (84.7% and 90.3%, respectively). The 3-year DFS rate (87.9%) and OS rate (96.7%) tended to be higher in the RELARC-D2 group than in the D2 control group (81.8% and 88.6%, respectively); however, these differences were not statistically significant (all P >0.05). Subgroup analysis according to pathological stage revealed that patients in the RELARC-D2 group with pN0 stage achieved a significantly superior 3-year OS rate than did those in the D2 control group (100% vs. 88.9%, P =0.008). We identified no statistically significant differences in survival rates between the remaining subgroups (all P >0.05). Conclusions: A high-quality surgical clinical trial with close follow-up can achieve perioperative safety and a trend toward improved survival outcomes.
Published: 2024
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14. Search for a Sub-eV Sterile Neutrino Using Daya Bay's Full Dataset.

Author: An FP, Bai WD, Balantekin AB, Bishai M, Blyth S, Cao GF, Cao J, Chang JF, Chang Y, Chen HS, Chen HY, Chen SM, Chen Y, Chen YX, Chen ZY, Cheng J, Cheng YC, Cheng ZK, Cherwinka JJ, Chu MC, Cummings JP, Dalager O, Deng FS, Ding XY, Ding YY, Diwan MV, Dohnal T, Dolzhikov D, Dove J, Dugas KV, Duyang HY, Dwyer DA, Gallo JP, Gonchar M, Gong GH, Gong H, Gu WQ, Guo JY, Guo L, Guo XH, Guo YH, Guo Z, Hackenburg RW, Han Y, Hans S, He M, Heeger KM, Heng YK, Hor YK, Hsiung YB, Hu BZ, Hu JR, Hu T, Hu ZJ, Huang HX, Huang JH, Huang XT, Huang YB, Huber P, Jaffe DE, Jen KL, Ji XL, Ji XP, Johnson RA, Jones D, Kang L, Kettell SH, Kohn S, Kramer M, Langford TJ, Lee J, Lee JHC, Lei RT, Leitner R, Leung JKC, Li F, Li HL, Li JJ, Li QJ, Li RH, Li S, Li S, Li SC, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin S, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu JC, Liu JL, Liu JX, Lu C, Lu HQ, Luk KB, Ma BZ, Ma XB, Ma XY, Ma YQ, Mandujano RC, Marshall C, McDonald KT, McKeown RD, Meng Y, Napolitano J, Naumov D, Naumova E, Nguyen TMT, Ochoa-Ricoux JP, Olshevskiy A, Park J, Patton S, Peng JC, Pun CSJ, Qi FZ, Qi M, Qian X, Raper N, Ren J, Morales Reveco C, Rosero R, Roskovec B, Ruan XC, Russell B, Steiner H, Sun JL, Tmej T, Tse WH, Tull CE, Tung YC, Viren B, Vorobel V, Wang CH, Wang J, Wang M, Wang NY, Wang RG, Wang W, Wang X, Wang YF, Wang Z, Wang Z, Wang ZM, Wei HY, Wei LH, Wei W, Wen LJ, Whisnant K, White CG, Wong HLH, Worcester E, Wu DR, Wu Q, Wu WJ, Xia DM, Xie ZQ, Xing ZZ, Xu HK, Xu JL, Xu T, Xue T, Yang CG, Yang L, Yang YZ, Yao HF, Ye M, Yeh M, Young BL, Yu HZ, Yu ZY, Yuan CZ, Yue BB, Zavadskyi V, Zeng S, Zeng Y, Zhan L, Zhang C, Zhang FY, Zhang HH, Zhang JL, Zhang JW, Zhang QM, Zhang SQ, Zhang XT, Zhang YM, Zhang YX, Zhang YY, Zhang ZJ, Zhang ZP, Zhang ZY, Zhao J, Zhao RZ, Zhou L, Zhuang HL, and Zou JH
Abstract: This Letter presents results of a search for the mixing of a sub-eV sterile neutrino with three active neutrinos based on the full data sample of the Daya Bay Reactor Neutrino Experiment, collected during 3158 days of detector operation, which contains 5.55×10^{6} reactor ν[over ¯]_{e} candidates identified as inverse beta-decay interactions followed by neutron capture on gadolinium. The analysis benefits from a doubling of the statistics of our previous result and from improvements of several important systematic uncertainties. No significant oscillation due to mixing of a sub-eV sterile neutrino with active neutrinos was found. Exclusion limits are set by both Feldman-Cousins and CLs methods. Light sterile neutrino mixing with sin^{2}2θ_{14}≳0.01 can be excluded at 95% confidence level in the region of 0.01 eV^{2}≲|Δm_{41}^{2}|≲0.1 eV^{2}. This result represents the world-leading constraints in the region of 2×10^{-4} eV^{2}≲|Δm_{41}^{2}|≲0.2 eV^{2}.
Published: 2024
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15. [Effects of tumor location and mismatch repair on clinicopathological features and survival for non-metastatic colon cancer: A retrospective, single center, cohort study].

Author: Sun Z, Zhou WX, Li KX, Wu B, Lin GL, Qiu HZ, Niu BZ, Sun XY, Lu JY, Xu L, and Xiao Y
Subjects: Humans, Male, Retrospective Studies, Female, Middle Aged, DNA Mismatch Repair, Adenocarcinoma pathology, Aged, Disease-Free Survival, Survival Rate, Cohort Studies, Prognosis, Kaplan-Meier Estimate, Proportional Hazards Models, Colonic Neoplasms pathology
Abstract: Objective: To analyze the differences in clinicopathological features of colon cancers and survival between patients with right- versus left-sided colon cancers. Methods: This was a retrospective cohort study. Information on patients with colon cancer from January 2016 to August 2020 was collected from the prospective registry database at Peking Union Medical College Hospital . Primary tumors located in the cecum, ascending colon, and proximal two-thirds of the transverse colon were defined as right-sided colon cancers (RCCs), whereas primary tumors located in the distal third of the transverse colon, descending colon, or sigmoid colon were defined as left-sided colon cancers (LCCs). Clinicopathological features were compared using the χ 2 test or Mann-Whitney U test. Survival was estimated by Kaplan-Meier curves and the log-rank test. Factors that differed significantly between the two groups were identified by multivariate survival analyses performed with the Cox proportional hazards function. One propensity score matching was performed to eliminate the effects of confounding factors. Results: The study cohort comprised 856 patients, with TNM Stage I disease, 391 (45.7%) with Stage II, and 336 (39.3%) with Stage III, including 442 (51.6%) with LCC and 414 (48.4%) with RCC and 129 (15.1%). Defective mismatch repair (dMMR) was identified in 139 patients (16.2%). Compared with RCC, the proportion of men (274/442 [62.0%] vs. 224/414 [54.1%], χ 2 =5.462, P =0.019), body mass index (24.2 [21.9, 26.6] kg/m 2 vs. 23.2 [21.3, 25.5] kg/m 2 , U =78,789.0, P <0.001), and well/moderately differentiated cancer (412/442 [93.2%] vs. 344/414 [83.1%], χ 2 =22.266, P <0.001) were higher in the LCC than the RCC group. In contrast, the proportion of dMMR (40/442 [9.0%] vs. 99/414 [23.9%], χ 2 =34.721, P <0.001) and combined vascular invasion (106/442[24.0%] vs. 125/414[30.2%], χ 2 =4.186, P =0.041) were lower in the LCC than RCC group. The median follow-up time for all patients was 48 (range 33, 59) months. The log-rank test revealed no significant differences in disease-free survival (DFS) ( P =0.668) or overall survival (OS) ( P =0.828) between patients with LCC versus RCC. Cox proportional hazards model showed that dMMR was significantly associated with a longer DFS (HR=0.419, 95%CI: 0.204‒0.862, P =0.018), whereas a higher proportion of T3-4 (HR=2.178, 95%CI: 1.089‒4.359, P =0.028), N+ (HR=2.126, 95%CI: 1.443‒3.133, P <0.001), and perineural invasion (HR=1.835, 95%CI: 1.115‒3.020, P =0.017) were associated with poor DFS. Tumor location was not associated with DFS or OS (all P >0.05). Subsequent analysis showed that RCC patients with dMMR had longer DFS than did RCC patients with pMMR (HR=0.338, 95%CI: 0.146‒0.786, P =0.012). However, the difference in OS between the two groups was not statistically significant (HR=0.340, 95%CI:0.103‒1.119, P =0.076). After propensity score matching for independent risk factors for DFS, the log-rank test revealed no significant differences in DFS ( P =0.343) or OS ( P =0.658) between patients with LCC versus RCC, whereas patient with dMMR had better DFS ( P =0.047) and OS ( P =0.040) than did patients with pMMR. Conclusions: Tumor location is associated with differences in clinicopathological features; however, this has no impact on survival. dMMR status is significantly associated with longer survival: this association may be stronger in RCC patients.
Published: 2024
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16. [Anal adenocarcinoma combined with perianal Paget disease involving vulva: a case report].

Author: Li GB, Shi WK, Zhang N, and Lin GL
Subjects: Female, Humans, Vulva, Adenocarcinoma, Anus Neoplasms, Neoplasms, Connective Tissue, Skin Neoplasms
Published: 2024
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17. [Analysis of influencing factors and clinical value of anterior peritoneal reflection for patients with rectal cancer].

Author: Zhang HQ, Wang ST, Sun Z, Lin GL, Wu B, Niu BZ, Lu JY, Xu L, and Xiao Y
Abstract: Objectives: To investigate the factors influencing the height of anterior peritoneal reflection (APR) for patients with rectal cancer, and to analyze the relationship between the APR and the lateral lymph node metastasis. Methods: Clinical data of 432 patients with tumor located within and below APR were retrospectively collected from the rectal cancer database at the Department of General Surgery, Peking Union Medical College Hospital from August 2020 to September 2022. Ninty-eight non-rectal cancer patients were also enrolled as a control group. There were 308 males and 124 females in the tumor group, aged ( M (IQR)) 62 (16) years (range: 24 to 85 years) and 53 males and 45 females in the control group, aged 60 (22) years (range: 27 to 87 years). The APR height, pelvis, and tumor-related parameters were measured by MRI. A multifactor linear regression model was established to analyze the dependent correlation factors of APR height. These factors of the two groups were matched by propensity score matching and their APR heights were compared after matching. An ordinal Logistic regression model was established to explore the relationship between APR-related parameters and radiographic lateral lymph node metastasis. Results: The APR height of the tumor group was (98.7±14.4) mm (range: 43.3 to 154.0 mm) and the control group was (95.1±12.7) mm (range: 68.0 to 137.9 mm). Multivariable linear regression revealed that the greater the weight ( B= 0.519, 95% CI : 0.399 to 0.640, P <0.01), the anterior pelvic depth ( B= 0.109, 95% CI : 0.005 to 0.213, P =0.039) and the smaller the bi-ischial diameter ( B= -0.172, 95% CI :-0.294 to -0.049, P =0.006), the higher the APR height. The tumor group had a higher APR height than the control group after propensity score matching ((98.3±14.2) mm vs. (95.1±12.7) mm, t =-1.992, P =0.047). Ordinal Logistic regression indicated that the longer segment of the tumor invade the nonperitoneal rectum was an independent influencing factor of radiographic lateral lymph node metastasis ( OR =1.016, 95% CI : 1.002 to 1.030, P =0.021), while the distance between the anal verge and the tumor was not ( OR =0.986, 95% CI : 0.972 to 1.000, P =0.058). Conclusions: The higher the weight, the deeper and narrower the pelvis, the higher the APR height. There is a certain relationship between APR and lateral lymph node metastasis on imaging.
Published: 2023
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18. [Development and validation of a prognostic prediction model for patients with stage Ⅰ to Ⅲ colon cancer incorporating high-risk pathological features].

Author: Li KX, Wu QB, Zhao FQ, Zhang JL, Luo SL, Hu SD, Wu B, Li HL, Lin GL, Qiu HZ, Lu JY, Xu L, Wang Z, Du XH, Kang L, Wang X, Wang ZQ, Liu Q, and Xiao Y
Subjects: Male, Female, Humans, Prognosis, Neoplasm Staging, Retrospective Studies, Lymph Nodes pathology, Risk Factors, Nomograms, Colonic Neoplasms surgery
Abstract: Objective: To examine a predictive model that incorporating high risk pathological factors for the prognosis of stage Ⅰ to Ⅲ colon cancer. Methods: This study retrospectively collected clinicopathological information and survival outcomes of stage Ⅰ~Ⅲ colon cancer patients who underwent curative surgery in 7 tertiary hospitals in China from January 1, 2016 to December 31, 2017. A total of 1 650 patients were enrolled, aged ( M (IQR)) 62 (18) years (range: 14 to 100). There were 963 males and 687 females. The median follow-up period was 51 months. The Cox proportional hazardous regression model was utilized to select high-risk pathological factors, establish the nomogram and scoring system. The Bootstrap resampling method was utilized for internal validation of the model, the concordance index (C-index) was used to assess discrimination and calibration curves were presented to assess model calibration. The Kaplan-Meier method was used to plot survival curves after risk grouping, and Cox regression was used to compare disease-free survival between subgroups. Results: Age ( HR =1.020, 95% CI : 1.008 to 1.033, P =0.001), T stage (T3: HR =1.995,95% CI :1.062 to 3.750, P =0.032;T4: HR =4.196, 95% CI : 2.188 to 8.045, P <0.01), N stage (N1: HR =1.834, 95% CI : 1.307 to 2.574, P <0.01; N2: HR =3.970, 95% CI : 2.724 to 5.787, P <0.01) and number of lymph nodes examined (≥36: HR =0.438, 95% CI : 0.242 to 0.790, P =0.006) were independently associated with disease-free survival. The C-index of the scoring model (model 1) based on age, T stage, N stage, and dichotomous variables of the lymph nodes examined (<12 and ≥12) was 0.723, and the C-index of the scoring model (model 2) based on age, T stage, N stage, and multi-categorical variables of the lymph nodes examined (<12, 12 to <24, 24 to <36, and ≥36) was 0.726. A scoring system was established based on age, T stage, N stage, and multi-categorical variables of lymph nodes examined, the 3-year DFS of the low-risk (≤1), middle-risk (2 to 4) and high-risk (≥5) group were 96.3% ( n =711), 89.0% ( n =626) and 71.4% ( n =313), respectively. Statistically significant difference was observed among groups ( P <0.01). Conclusions: The number of lymph nodes examined was an independent prognostic factor for disease-free survival after curative surgery in patients with stage Ⅰ to Ⅲ colon cancer. Incorporating the number of lymph nodes examined as a multi-categorical variable into the T and N staging system could improve prognostic predictive validity.
Published: 2023
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19. [Advances in three-dimensional tumor models for colorectal cancer].

Author: Wang CT, Zhou JL, Lin GL, Yin SY, Cong L, Zhang GN, An Y, and Qiu XY
Subjects: Humans, Cell Culture Techniques, Tumor Microenvironment, Organoids pathology, Colorectal Neoplasms drug therapy, Colorectal Neoplasms pathology
Abstract: Conventional tumor culture models include two-dimensional tumor cell cultures and xenograft models. The former has disadvantages including lack of tumor heterogeneity and poor clinical relevance, while the latter are limited by the slow growth, low engraftment successful rate, and high cost. In recent years, in vitro three-dimensional (3D) tumor models have emerged as the tool to better recapitulate the spatial structure and the in vivo environment of tumors. In addition, they preserve the pathological and genetic features of tumor cells and reflect the complex intracellular and extracellular interactions of tumors, which have become a powerful tool for investigating the tumor mechanism, drug screening, and personalized cancer treatment. 3D tumor model technologies such as spheroids, organoids, and microfluidic devices are maturing. Application of new technologies such as co-culture, 3D bioprinting, and air-liquid interface has further improved the clinical relevance of the models. Some models recapitulate the tumor microenvironment, and some can even reconstitute endogenous immune components and microvasculature. In recent years, some scholars have combined xenograft models with organoid technology to develop matched in vivo / in vitro model biobanks, giving full play to the advantages of the two technologies, and providing an ideal research platform for individualized precision therapy for specific molecular targets in certain subtypes of tumors. So far, the above technologies have been widely applied in the field of colorectal cancer research. Our research team is currently studying upon the application of patient-derived tumor cell-like clusters, a self-assembly 3D tumor model, in guiding the selection of postoperative chemotherapy regimens for colorectal cancer. A high modeling success rate and satisfactory results in the drug screening experiments have been achieved. There is no doubt that with the advancement of related technologies, 3D tumor models will play an increasingly important role in the research and clinical practice of colorectal cancer.
Published: 2023
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20. Improved Measurement of the Evolution of the Reactor Antineutrino Flux and Spectrum at Daya Bay.

Author: An FP, Bai WD, Balantekin AB, Bishai M, Blyth S, Cao GF, Cao J, Chang JF, Chang Y, Chen HS, Chen HY, Chen SM, Chen Y, Chen YX, Cheng J, Cheng J, Cheng YC, Cheng ZK, Cherwinka JJ, Chu MC, Cummings JP, Dalager O, Deng FS, Ding YY, Diwan MV, Dohnal T, Dolzhikov D, Dove J, Dugas KV, Duyang HY, Dwyer DA, Gallo JP, Gonchar M, Gong GH, Gong H, Gu WQ, Guo JY, Guo L, Guo XH, Guo YH, Guo Z, Hackenburg RW, Han Y, Hans S, He M, Heeger KM, Heng YK, Hor YK, Hsiung YB, Hu BZ, Hu JR, Hu T, Hu ZJ, Huang HX, Huang JH, Huang XT, Huang YB, Huber P, Jaffe DE, Jen KL, Ji XL, Ji XP, Johnson RA, Jones D, Kang L, Kettell SH, Kohn S, Kramer M, Langford TJ, Lee J, Lee JHC, Lei RT, Leitner R, Leung JKC, Li F, Li HL, Li JJ, Li QJ, Li RH, Li S, Li SC, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin S, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu JC, Liu JL, Liu JX, Lu C, Lu HQ, Luk KB, Ma BZ, Ma XB, Ma XY, Ma YQ, Mandujano RC, Marshall C, McDonald KT, McKeown RD, Meng Y, Napolitano J, Naumov D, Naumova E, Nguyen TMT, Ochoa-Ricoux JP, Olshevskiy A, Park J, Patton S, Peng JC, Pun CSJ, Qi FZ, Qi M, Qian X, Raper N, Ren J, Morales Reveco C, Rosero R, Roskovec B, Ruan XC, Russell B, Steiner H, Sun JL, Tmej T, Treskov K, Tse WH, Tull CE, Tung YC, Viren B, Vorobel V, Wang CH, Wang J, Wang M, Wang NY, Wang RG, Wang W, Wang X, Wang Y, Wang YF, Wang Z, Wang Z, Wang ZM, Wei HY, Wei LH, Wen LJ, Whisnant K, White CG, Wong HLH, Worcester E, Wu DR, Wu Q, Wu WJ, Xia DM, Xie ZQ, Xing ZZ, Xu HK, Xu JL, Xu T, Xue T, Yang CG, Yang L, Yang YZ, Yao HF, Ye M, Yeh M, Young BL, Yu HZ, Yu ZY, Yue BB, Zavadskyi V, Zeng S, Zeng Y, Zhan L, Zhang C, Zhang FY, Zhang HH, Zhang JL, Zhang JW, Zhang QM, Zhang SQ, Zhang XT, Zhang YM, Zhang YX, Zhang YY, Zhang ZJ, Zhang ZP, Zhang ZY, Zhao J, Zhao RZ, Zhou L, Zhuang HL, and Zou JH
Subjects: Uranium, Nuclear Reactors
Abstract: Reactor neutrino experiments play a crucial role in advancing our knowledge of neutrinos. In this Letter, the evolution of the flux and spectrum as a function of the reactor isotopic content is reported in terms of the inverse-beta-decay yield at Daya Bay with 1958 days of data and improved systematic uncertainties. These measurements are compared with two signature model predictions: the Huber-Mueller model based on the conversion method and the SM2018 model based on the summation method. The measured average flux and spectrum, as well as the flux evolution with the ^{239}Pu isotopic fraction, are inconsistent with the predictions of the Huber-Mueller model. In contrast, the SM2018 model is shown to agree with the average flux and its evolution but fails to describe the energy spectrum. Altering the predicted inverse-beta-decay spectrum from ^{239}Pu fission does not improve the agreement with the measurement for either model. The models can be brought into better agreement with the measurements if either the predicted spectrum due to ^{235}U fission is changed or the predicted ^{235}U, ^{238}U, ^{239}Pu, and ^{241}Pu spectra are changed in equal measure.
Published: 2023
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21. Precision Measurement of Reactor Antineutrino Oscillation at Kilometer-Scale Baselines by Daya Bay.

Author: An FP, Bai WD, Balantekin AB, Bishai M, Blyth S, Cao GF, Cao J, Chang JF, Chang Y, Chen HS, Chen HY, Chen SM, Chen Y, Chen YX, Chen ZY, Cheng J, Cheng ZK, Cherwinka JJ, Chu MC, Cummings JP, Dalager O, Deng FS, Ding YY, Ding XY, Diwan MV, Dohnal T, Dolzhikov D, Dove J, Duyang HY, Dwyer DA, Gallo JP, Gonchar M, Gong GH, Gong H, Gu WQ, Guo JY, Guo L, Guo XH, Guo YH, Guo Z, Hackenburg RW, Han Y, Hans S, He M, Heeger KM, Heng YK, Hor YK, Hsiung YB, Hu BZ, Hu JR, Hu T, Hu ZJ, Huang HX, Huang JH, Huang XT, Huang YB, Huber P, Jaffe DE, Jen KL, Ji XL, Ji XP, Johnson RA, Jones D, Kang L, Kettell SH, Kohn S, Kramer M, Langford TJ, Lee J, Lee JHC, Lei RT, Leitner R, Leung JKC, Li F, Li HL, Li JJ, Li QJ, Li RH, Li S, Li SC, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin S, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu JC, Liu JL, Liu JX, Lu C, Lu HQ, Luk KB, Ma BZ, Ma XB, Ma XY, Ma YQ, Mandujano RC, Marshall C, McDonald KT, McKeown RD, Meng Y, Napolitano J, Naumov D, Naumova E, Nguyen TMT, Ochoa-Ricoux JP, Olshevskiy A, Pan HR, Park J, Patton S, Peng JC, Pun CSJ, Qi FZ, Qi M, Qian X, Raper N, Ren J, Morales Reveco C, Rosero R, Roskovec B, Ruan XC, Russell B, Steiner H, Sun JL, Tmej T, Treskov K, Tse WH, Tull CE, Viren B, Vorobel V, Wang CH, Wang J, Wang M, Wang NY, Wang RG, Wang W, Wang X, Wang Y, Wang YF, Wang Z, Wang Z, Wang ZM, Wei HY, Wei LH, Wei W, Wen LJ, Whisnant K, White CG, Wong HLH, Worcester E, Wu DR, Wu Q, Wu WJ, Xia DM, Xie ZQ, Xing ZZ, Xu HK, Xu JL, Xu T, Xue T, Yang CG, Yang L, Yang YZ, Yao HF, Ye M, Yeh M, Young BL, Yu HZ, Yu ZY, Yue BB, Zavadskyi V, Zeng S, Zeng Y, Zhan L, Zhang C, Zhang FY, Zhang HH, Zhang JL, Zhang JW, Zhang QM, Zhang SQ, Zhang XT, Zhang YM, Zhang YX, Zhang YY, Zhang ZJ, Zhang ZP, Zhang ZY, Zhao J, Zhao RZ, Zhou L, Zhuang HL, and Zou JH
Abstract: We present a new determination of the smallest neutrino mixing angle θ_{13} and the mass-squared difference Δm_{32}^{2} using a final sample of 5.55×10^{6} inverse beta-decay (IBD) candidates with the final-state neutron captured on gadolinium. This sample is selected from the complete dataset obtained by the Daya Bay reactor neutrino experiment in 3158 days of operation. Compared to the previous Daya Bay results, selection of IBD candidates has been optimized, energy calibration refined, and treatment of backgrounds further improved. The resulting oscillation parameters are sin^{2}2θ_{13}=0.0851±0.0024, Δm_{32}^{2}=(2.466±0.060)×10^{-3} eV^{2} for the normal mass ordering or Δm_{32}^{2}=-(2.571±0.060)×10^{-3} eV^{2} for the inverted mass ordering.
Published: 2023
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22. [Predictive value of MRI pelvic measurements for "difficult pelvis" during total mesorectal excision].

Author: Sun Z, Hou WY, Liu JJ, Xue HD, Xu PR, Wu B, Lin GL, Xu L, Lu JY, and Xiao Y
Subjects: Humans, Male, Middle Aged, Female, Retrospective Studies, Pelvis pathology, Magnetic Resonance Imaging, Treatment Outcome, Laparoscopy methods, Rectal Neoplasms surgery, Rectal Neoplasms pathology
Abstract: Objective: Total mesorectal resection (TME) is difficult to perform for rectal cancer patients with anatomical confines of the pelvis or thick mesorectal fat. This study aimed to evaluate the ability of pelvic dimensions to predict the difficulty of TME, and establish a nomogram for predicting its difficulty. Methods: The inclusion criteria for this retrospective study were as follows: (1) tumor within 15 cm of the anal verge; (2) rectal cancer confirmed by preoperative pathological examination; (3) adequate preoperative MRI data; (4) depth of tumor invasion T1-4a; and (5) grade of surgical difficulty available. Patients who had undergone non-TME surgery were excluded. A total of 88 patients with rectal cancer who underwent TME between March 2019 and November 2021 were eligible for this study. The system for scaling difficulty was as follows: Grade I, easy procedure, no difficulties; Grade II, difficult procedure, but no impact on specimen quality (complete TME); Grade III, difficult procedure, with a slight impact on specimen quality (near-complete TME); Grade IV: very difficult procedure, with remarkable impact on specimen quality (incomplete TME). We classified Grades I-II as no surgical difficulty and grades III-IV as surgical difficulty. Pelvic parameters included pelvic inlet length, anteroposterior length of the mid-pelvis, pelvic outlet length, pubic tubercle height, sacral length, sacral depth, distance from the pubis to the pelvic floor, anterior pelvic depth, interspinous distance, and inter-tuberosity distance. Univariate and multivariate logistic regression analyses were performed to identify the factors associated with the difficulty of TME, and a nomogram predicting the difficulty of the procedure was established. Results: The study cohort comprised 88 patients, 30 (34.1%) of whom were classified as having undergone difficult procedures and 58 (65.9%) non-difficult procedures. The median age was 64 years (56-70), 51 patients were male and 64 received neoadjuvant therapy. The median pelvic inlet length, anteroposterior length of the mid-pelvis, pelvic outlet length, pubic tubercle height, sacral length, sacral depth, distance from the pubis to the pelvic floor, anterior pelvic depth, interspinous distance, and inter-tuberosity distance were 12.0 cm, 11.0 cm, 8.6 cm, 4.9 cm, 12.6 cm, 3.7 cm, 3.0 cm, 13.3 cm, 10.2 cm, and 12.2 cm, respectively. Multivariable analyses showed that preoperative chemoradiotherapy (OR=4.97,95% CI: 1.25-19.71, P =0.023), distance between the tumor and the anal verge (OR=1.31, 95% CI: 1.02-1.67, P =0.035) and pubic tubercle height (OR=3.36, 95% CI: 1.56-7.25, P =0.002) were associated with surgical difficulty. We then built and validated a predictive nomogram based on the above three variables (AUC = 0.795, 95%CI: 0.696-0.895). Conclusion: Our research demonstrated that our system for scaling surgical difficulty of TME is useful and practical. Preoperative chemoradiotherapy, distance between tumor and anal verge, and pubic tubercle height are risk factors for surgical difficulty. These data may aid surgeons in planning appropriate surgical procedures.
Published: 2022
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23. [Risk factor and early diagnosis of anastomotic leakage after rectal cancer surgery].

Author: Shi WK, Qiu XY, Li YH, and Lin GL
Subjects: Humans, Rectum surgery, Risk Factors, Early Diagnosis, Anastomotic Leak diagnosis, Anastomotic Leak etiology, Anastomotic Leak surgery, Rectal Neoplasms surgery, Rectal Neoplasms complications
Abstract: Anastomotic leakage (AL) is one of the most serious complications after sphincter- preserving surgery for rectal cancer, which can significantly prolong the length of stay of patients, increase perioperative mortality, cause dysfunction, shorten overall survival and recurrence-free survival of patients. In order to reduce the serious consequences caused by AL, prediction of AL through preoperative and intraoperative risk factors are of great importance. However, the influences of neoadjuvant chemoradiotherapy, protective stoma, laparoscopic surgery and some intraoperative manipulations on AL are still controversial. Through the auxiliary judgment of anastomotic blood supply during operation, such as indocyanine green imaging, hemodynamic ultrasound, etc., it is expected to achieve the source control of AL. Early diagnosis of AL can be achieved by attention to clinical manifestations and drainage, examination of peripheral blood, drainage and intestinal flora, identification of high risk factors such as fever, diarrhea and increased infectious indicators, and timely administration of CT with contrast enema.
Published: 2022
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24. [Analysis of prognosis factors of postoperative cardiac complications in colorectal cancer patients with comorbid coronary artery disease].

Author: Chang GJ, Lu JY, Hou WY, Xue ZG, Wu B, Lin GL, Zhou JL, Xu L, Zhang GN, Qiu HZ, and Xiao Y
Abstract: Objective: To examine the prognosis factors of postoperative cardiac complications in colorectal cancer patients co-morbidated with coronary artery disease. Methods: Clinical data of 449 patients colorectal cancer patients co-morbidated with coronary artery disease accepted redical surgery from April 2013 to April 2020 at Department of General Surgery, Peking Union Medical College Hospital were analyzed retrospectively. There were 306 males and 143 females, aging (68.7±8.9) years (range: 44 to 89 years). Postoperative acute coronary syndrome, new-onset arrhythmia and heart failure that causes clinical symptoms were recorded as cardiac complications. t test, χ 2 test and Fisher exact test were used for univariate analysis of prognosis factors of postoperative cardiac events. The variables with P <0.05 were included in the multivariate Logistic regression was used to determine the independent prognosis factors. Results: After surgery, 44 patients (9.8%) suffered from at least one cardiac event, including 30 patients with acute coronary syndrome, 19 patients with new-onset arrhythmia and 9 patients with heart failure. There were 3 deaths in the cohort within 30 days after surgery. Two patients died from cardiac-related complications, and one from septic shock due to postoperative anastomotic leaks. On Univariate analysis showed that cardiac complications were associated with age ≥80 years, co-morbidated diabetes, emergency surgery, re-operation, anastomotic leakage, intestinal flora disorder and elevation of preoperative neutrophil-lymphocyte ratio (χ 2 : 4.308 to 12.219, all P <0.05). Multivariate Logistic regression analysis identified age ≥80 years( OR =3.195, 95% CI: 1.379 to 7.407, P =0.007), co-morbidated diabetes ( OR =2.551, 95% CI : 1.294 to 5.025, P =0.007), emergency surgery ( OR =4.717, 95% CI : 1.052 to 20.833, P =0.043), and elevated preoperative neutrophil-lymphocyte ratio ( OR =1.114, 95% CI : 1.018 to 1.218, P =0.018) as independent prognosis factors for cardiac complications. Conclusions: Emergency surgery, advanced age, co-morbidated type 2 diabetes and elevated preoperative neutrophil-lymphocyte ratio may increase the risk of postoperative cardiac complications in colorectal cancer patients with coronary artery disease. Surgeons should strictly master surgical indications, pay attention to preoperative assessment, perioperative monitoring, and diagnosis and treatment of postoperative complications in order to reduce the risk of complications.
Published: 2022
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25. [Safety and prognosis analysis of transanal total mesorectal excision versus laparoscopic mesorectal excision for mid-low rectal cancer].

Author: Sun R, Cong L, Qiu HZ, Lin GL, Wu B, Niu BZ, Sun XY, Zhou JL, Xu L, Lu JY, and Xiao Y
Subjects: Anastomotic Leak etiology, Humans, Postoperative Complications epidemiology, Prognosis, Prospective Studies, Rectum pathology, Rectum surgery, Retrospective Studies, Treatment Outcome, Laparoscopy methods, Rectal Neoplasms pathology, Transanal Endoscopic Surgery methods
Abstract: Objective: To compare the short-term and long-term outcomes between transanal total mesorectal excision (taTME) and laparoscopic total mesorectal excision (laTME) for mid-to-low rectal cancer and to evaluate the learning curve of taTME. Methods: This study was a retrospective cohort study. Firstly, consecutive patients undergoing total mesorectal excision who were registered in the prospective established database of Division of Colorectal Diseases, Department of General Surgery, Peking Union Medical College Hospital during July 2014 to June 2020 were recruited. The enrolled patients were divided into taTME and laTME group. The demographic data, clinical characteristics, neoadjuvant treatment, intraoperative and postoperative complications, pathological results and follow-up data were extracted from the database. The primary endpoint was the incidence of anastomotic leakage and the secondary endpoints included the 3-year disease-free survival (DFS) and the 3-year local recurrence rate. Independent t -test for comparison between groups of normally distributed measures; skewed measures were expressed as M (range). Categorical variables were expressed as examples (%) and the χ(2) or Fisher exact probability was used for comparison between groups. When comparing the incidence of anastomotic leakage, 5 variables including sex, BMI, clinical stage evaluated by MRI, distance from tumor to anal margin evaluated by MRI, and whether receiving neoadjuvant treatment were balanced by propensity score matching (PSM) to adjust confounders. Kaplan-Meier curve and Log-rank test were used to compare the DFS of two groups. Cox proportional hazard model was used to analyze and determine the independent risk factors affecting the DFS of patients with mid-low rectal cancer. Secondly, the data of consecutive patients undergoing taTME performed by the same surgical team (the trananal procedures were performed by the same main surgeon) from February 2017 to March 2021 were separately extracted and analyzed. The multidimensional cumulative sum (CUSUM) control chart was used to draw the learning curve of taTME. The outcomes of 'mature' taTME cases through learning curve were compared with laTME cases and the independent risk factors of DFS of 'mature' cases were also analyzed. Results: Two hundred and forty-three patients were eventually enrolled, including 182 undergoing laTME and 61 undergoing taTME. After PSM, both fifty-two patients were in laTME group and taTME group respectively, and patients of these two groups had comparable characteristics in sex, age, BMI, clinical tumor stage, distance from tumor to anal margin by MRI, mesorectal fasciae (MRF) and extramural vascular invasion (EMVI) by MRI and proportion of receiving neoadjuvant treatment. After PSM, as compared to laTME group, taTME group showed significantly longer operation time [(198.4±58.3) min vs. (147.9±47.3) min, t =-4.321, P <0.001], higher ratio of blood loss >100 ml during surgery [17.3% (9/52) vs. 0, P =0.003], higher incidence of anastomotic leakage [26.9% (14/52) vs. 3.8% (2/52), χ(2)=10.636, P =0.001] and higher morbidity of overall postoperative complications [55.8%(29/52) vs. 19.2% (10/52), χ(2)=14.810, P <0.001]. Total harvested lymph nodes and circumferential resection margin involvement were comparable between two groups (both P >0.05). The median follow-up for the whole group was 24 (1 to 72) months, with 4 cases lost, giving a follow-up rate of 98.4% (239/243). The laTME group had significantly better 3-year DFS than taTME group (83.9% vs. 73.0%, P =0.019), while the 3-year local recurrence rate was similar in two groups (1.7% vs. 3.6%, P =0.420). Multivariate analysis showed that and taTME surgery (HR=3.202, 95%CI: 1.592-6.441, P =0.001) the postoperative pathological staging of UICC stage II (HR=13.862, 95%CI:1.810-106.150, P =0.011), stage III (HR=8.705, 95%CI: 1.104-68.670, P =0.040) were independent risk factors for 3-year DFS. Analysis of taTME learning curve revealed that surgeons would cross over the learning stage after performing 28 cases. To compare the two groups excluding the cases within the learning stage, there was no significant difference between two groups after PSM no matter in the incidence of anastomotic leakage [taTME: 6.7%(1/15); laTME: 5.3% (2/38), P =1.000] or overall complications [taTME: 33.3%(5/15), laTME: 26.3%(10/38), P =0.737]. The taTME was still an independent risk factor of 3-year DFS only analyzing patients crossing over the learning stage (HR=5.351, 95%CI:1.666-17.192, P =0.005), and whether crossing over the learning stage was not the independent risk factor of 3-year DFS for mid-low rectal cancer patients undergoing taTME (HR=0.954, 95%CI:0.227-4.017, P =0.949). Conclusions: Compared with conventional laTME, taTME may increase the risk of anastomotic leakage and compromise the oncological outcomes. Performing taTME within the learning stage may significantly increase the risk of postoperative anastomotic leakage.
Published: 2022
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26. [Quality of life of patients with locally advanced rectal cancer after neoadjuvant therapy and sphincter-preserving surgery].

Author: Shi WK, Li YH, Qiu XY, Xiao Y, Zhou JL, Wu B, and Lin GL
Subjects: Dysuria, Female, Humans, Lactation, Male, Middle Aged, Neoadjuvant Therapy, Pain, Postoperative Complications, Quality of Life, Retrospective Studies, Syndrome, Treatment Outcome, Dyspareunia, Neoplasms, Second Primary, Rectal Neoplasms surgery, Urinary Incontinence
Abstract: Objective: To investigate quality of life (QoL) of patients with locally advanced rectal cancer (LARC) who underwent low anterior resection with protective stoma under neoadjuvant therapy mode, and to explore the changes of QoL of patients from before neoadjuvant therapy to 12 months after stoma reversal. Methods: A descriptive case series study was carried out. A retrospective study was performed on patients with mid and low LARC who received complete neoadjuvant long course radiotherapy and chemotherapy, followed by radical low anterior resection (LAR) combined with protective stoma at Peking Union Medical College Hospital from December 2017 to January 2020. Inclusion criteria: (1) patients with rectal MRI assessment of mT3-4b or mN1-2 without distant metastasis (M0) before neoadjuvant therapy; (2) distance from tumor lower margin to the anal verge <12 cm; (3) rectal adenocarcinoma confirmed by biopsy before neoadjuvant therapy; (4) complete cycle of neoadjuvant therapy; (5) patients undergoing radical LAR with sphincter preservation and protective ostomy; (6) patients receiving follow-up for more than 12 months after stoma reversal. Exclusion criteria: (1) patients as grade Ⅳ to Ⅴclassified by the American Society of Anesthesiologists (ASA); (2) patients with multiple primary colorectal cancer; (3) patients with history of other malignant tumors in the past 5 years; (4) patients of emergency surgery; (5) pregnant or lactating women; (6) patients with history of severe mental illness; (7) patients with contraindication of MRI, radiotherapy, chemotherapy, or surgical treatment. A total of 83 patients were enrolled, including 51 males and 28 females with median age of 59 years and mean BMI of (24.4±3.1) kg/m(2). EORTC QLQ-CR29, international erectile function index (IIEF), Wexner constipation score and low anterior resection syndrome (LARS) score were applied to investigate the QoL of the patients before neoadjuvant therapy, 3 and 12 months after ostomy reversal, including rectal anal function and sexual function. M (P25, P75) was used for the scores of the scale. Results: (1) EORTC QLQ-CR29 score showed that before neoadjuvant therapy, before surgery, 3 months and 12 months after ostomy reversal, anxiety [64.4 (52, 0, 82.5), 75.3 (66.0, 89.5), 82.6 (78.5, 90.0), 83.6 (78.0, 91.0)] and concern about body image [76.8 (66.0, 92.0), 81.1 (76.5, 91.5), 85.5 (82.5, 94.0), 86.1 (82.0, 92.0)] were improved (all P <0.01); pelvic pain [5.4 (2.0, 8.0), 5, 0 (2.0, 7.8), 3.9 (1.0, 5.0), 3.0 (1.0, 5.0)], urinary incontinence [15.7 (7.0, 22.0), 11.1 (0, 17.5), 10.0 (0, 17.0), 9.9 (0, 16.0)], impotence [14.3 (4.2, 19.0), 12.2 (0, 16.8), 5.6 (0, 10.0), 5.2 (0.2, 8.0)], urinate [26.4 (13.0, 38.5), 13.9 (0, 20.0), 13.4 (2.5, 21.5), 13.2 (2.0, 20.0)] and mucous bloody stool [4.7 (3.0, 6.0), 2.6 (0, 5.0), 2.2 (0, 5.0), 1.9 (0, 4.0)] were improved as well (all P <0.01). The scores fluctuated in the improvement of male sexual function, abdominal pain, dry mouth, worry about body mass change, skin pain and dyspareunia, but the symptoms were significantly improved after ostomy reversal compared with before neoadjuvant therapy (all P <0.05). There were no significant changes in female sexual function, dysuria, dysgeusia and fecal incontinence after ostomy reversal compared with before neoadjuvant therapy (all P >0.05). (2) IIEF scale showed that all scores were similar before and after neoadjuvant therapy (all P >0.05). (3) Rectal and anal function scale revealed that before neoadjuvant therapy, before operation, 3 months and 12 months after stoma reversal, gas incontinence [3.1 (0, 4.0), 2.3 (0, 4.0), 1.8 (0, 4.0), 1.2 (0, 3.0)] and urgent defecation [7.2 (0, 11.0), 5.2 (0, 11.0), 2.9 (0, 9.0), 1.7 (0, 0)] were improved (all P <0.001). In terms of improving incomplete emptying sensation, the symptoms fluctuated, but the symptoms improved significantly after ostomy reversal compared with before neoadjuvant therapy (all P <0.05). While the symptoms of assistance with defecation [0 (0, 0), 0.7 (0, 1.0), 0.6 (0, 1.0), 0.7 (0, 1.0)] and defecation failure [0.2 (0, 0), 1.0 (0, 2.0), 0.8 (0, 1.5), 0.8 (0, 1.0)] showed a worsening trend (all P <0.001). Stratified analysis was performed on patients with different efficacy of neoadjuvant therapy to compare the changes in QoL before and after neoadjuvant therapy. Patients with less sensitive and more sensitive neoadjuvant therapy showed similar changes in function and symptoms. Patients with less sensitive therapy showed significant improvement in dysuria, urinary incontinence, skin pain and dyspareunia (all P <0.05), and the symptom of defecation frequency in more sensitive patients was significantly improved ( P <0.05). Conclusions: For patients with LARC, neoadjuvant radiochemotherapy combined with radical LAR and protective stoma can improve QoL in many aspects. It is noted that patients show a worsening trend in the need for assistance with defecation and in defecation failure.
Published: 2022
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27. [Risk factors of postoperative surgical site infection in colon cancer based on a single center database].

Author: Guo YC, Sun R, Wu B, Lin GL, Qiu HZ, Li KX, Hou WY, Sun XY, Niu BZ, Zhou JL, Lu JY, Cong L, Xu L, and Xiao Y
Subjects: Case-Control Studies, Humans, Retrospective Studies, Risk Factors, Colonic Neoplasms surgery, Surgical Wound Infection etiology
Abstract: Objective: To explore the incidence and risk factors of postoperative surgical site infection (SSI) after colon cancer surgery. Methods: A retrospective case-control study was performed. Patients diagnosed with colon cancer who underwent radical surgery between January 2016 and May 2021 were included, and demographic characteristics, comorbidities, laboratory tests, surgical data and postoperative complications were extracted from the specialized prospective database at Department of General Surgery, Peking Union Medical College Hospital. Case exclusion criteria: (1) simultaneously multiple primary colon cancer; (2) segmental resection, subtotal colectomy, or total colectomy; (3) patients undergoing colostomy/ileostomy during the operation or in the state of colostomy/ileostomy before the operation; (4) patients receiving natural orifice specimen extraction surgery or transvaginal colon surgery; (5) patients with the history of colectomy; (6) emergency operation due to intestinal obstruction, perforation and acute bleeding; (7) intestinal diversion operation; (8) benign lesions confirmed by postoperative pathology; (9) patients not following the colorectal clinical pathway of our department for intestinal preparation and antibiotic application. Univariate analysis and multivariate analysis were used to determine the risk factors of SSI after colon cancer surgery. Results: A total of 1291 patients were enrolled in the study. 94.3% (1217/1291) of cases received laparoscopic surgery. The incidence of overall SSI was 5.3% (69/1291). According to tumor location, the incidence of SSI in the right colon, transverse colon, left colon and sigmoid colon was 8.6% (40/465), 5.2% (11/213), 7.1% (7/98) and 2.1% (11/515) respectively. According to resection range, the incidence of SSI after right hemicolectomy, transverse colectomy, left hemicolectomy and sigmoid colectomy was 8.2% (48/588), 4.5% (2/44), 4.8% (8 /167) and 2.2% (11/492) respectively. Univariate analysis showed that preoperative BUN≥7.14 mmol/L, tumor site, resection range, intestinal anastomotic approach, postoperative diarrhea, anastomotic leakage, postoperative pneumonia, and anastomotic technique were related to SSI (all P <0.05). Multivariate analysis revealed that anastomotic leakage (OR=22.074, 95%CI: 6.172-78.953, P <0.001), pneumonia (OR=4.100, 95%CI: 1.546-10.869, P =0.005), intracorporeal anastomosis (OR=5.288, 95%CI: 2.919-9.577, P <0.001) were independent risk factors of SSI. Subgroup analysis showed that in right hemicolectomy, the incidence of SSI in intracorporeal anastomosis was 19.8% (32/162), which was significantly higher than that in extracorporeal anastomosis (3.8%, 16/426, χ(2)=40.064, P <0.001). In transverse colectomy [5.0% (2/40) vs. 0, χ(2)=0.210, P =1.000], left hemicolectomy [5.4% (8/148) vs. 0, χ(2)=1.079, P =0.599] and sigmoid colectomy [2.1% (10/482) vs. 10.0% (1/10), χ(2)=2.815, P =0.204], no significant differences of SSI incidence were found between intracorporeal anastomosis and extracorporeal anastomosis (all P >0.05). Conclusions: The incidence of SSI increases with the resection range from sigmoid colectomy to right hemicolectomy. Intracorporeal anastomosis and postoperative anastomotic leakage are independent risk factors of SSI. Attentions should be paid to the possibility of postoperative pneumonia and actively effective treatment measures should be carried out.
Published: 2022
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28. Joint Determination of Reactor Antineutrino Spectra from ^{235}U and ^{239}Pu Fission by Daya Bay and PROSPECT.

Author: An FP, Andriamirado M, Balantekin AB, Band HR, Bass CD, Bergeron DE, Berish D, Bishai M, Blyth S, Bowden NS, Bryan CD, Cao GF, Cao J, Chang JF, Chang Y, Chen HS, Chen SM, Chen Y, Chen YX, Cheng J, Cheng ZK, Cherwinka JJ, Chu MC, Classen T, Conant AJ, Cummings JP, Dalager O, Deichert G, Delgado A, Deng FS, Ding YY, Diwan MV, Dohnal T, Dolinski MJ, Dolzhikov D, Dove J, Dvořák M, Dwyer DA, Erickson A, Foust BT, Gaison JK, Galindo-Uribarri A, Gallo JP, Gilbert CE, Gonchar M, Gong GH, Gong H, Grassi M, Gu WQ, Guo JY, Guo L, Guo XH, Guo YH, Guo Z, Hackenburg RW, Hans S, Hansell AB, He M, Heeger KM, Heffron B, Heng YK, Hor YK, Hsiung YB, Hu BZ, Hu JR, Hu T, Hu ZJ, Huang HX, Huang JH, Huang XT, Huang YB, Huber P, Koblanski J, Jaffe DE, Jayakumar S, Jen KL, Ji XL, Ji XP, Johnson RA, Jones DC, Kang L, Kettell SH, Kohn S, Kramer M, Kyzylova O, Lane CE, Langford TJ, LaRosa J, Lee J, Lee JHC, Lei RT, Leitner R, Leung JKC, Li F, Li HL, Li JJ, Li QJ, Li RH, Li S, Li SC, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin S, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu JC, Liu JL, Liu JX, Lu C, Lu HQ, Lu X, Luk KB, Ma BZ, Ma XB, Ma XY, Ma YQ, Mandujano RC, Maricic J, Marshall C, McDonald KT, McKeown RD, Mendenhall MP, Meng Y, Meyer AM, Milincic R, Mueller PE, Mumm HP, Napolitano J, Naumov D, Naumova E, Neilson R, Nguyen TMT, Nikkel JA, Nour S, Ochoa-Ricoux JP, Olshevskiy A, Palomino JL, Pan HR, Park J, Patton S, Peng JC, Pun CSJ, Pushin DA, Qi FZ, Qi M, Qian X, Raper N, Ren J, Morales Reveco C, Rosero R, Roskovec B, Ruan XC, Searles M, Steiner H, Sun JL, Surukuchi PT, Tmej T, Treskov K, Tse WH, Tull CE, Tyra MA, Varner RL, Venegas-Vargas D, Viren B, Vorobel V, Wang CH, Wang J, Wang M, Wang NY, Wang RG, Wang W, Wang W, Wang X, Wang Y, Wang YF, Wang Z, Wang Z, Wang ZM, Weatherly PB, Wei HY, Wei LH, Wen LJ, Whisnant K, White C, Wilhelmi J, Wong HLH, Woolverton A, Worcester E, Wu DR, Wu FL, Wu Q, Wu WJ, Xia DM, Xie ZQ, Xing ZZ, Xu HK, Xu JL, Xu T, Xue T, Yang CG, Yang L, Yang YZ, Yao HF, Ye M, Yeh M, Young BL, Yu HZ, Yu ZY, Yue BB, Zavadskyi V, Zeng S, Zeng Y, Zhan L, Zhang C, Zhang FY, Zhang HH, Zhang JW, Zhang QM, Zhang SQ, Zhang X, Zhang XT, Zhang YM, Zhang YX, Zhang YY, Zhang ZJ, Zhang ZP, Zhang ZY, Zhao J, Zhao RZ, Zhou L, Zhuang HL, and Zou JH
Abstract: A joint determination of the reactor antineutrino spectra resulting from the fission of ^{235}U and ^{239}Pu has been carried out by the Daya Bay and PROSPECT Collaborations. This Letter reports the level of consistency of ^{235}U spectrum measurements from the two experiments and presents new results from a joint analysis of both data sets. The measurements are found to be consistent. The combined analysis reduces the degeneracy between the dominant ^{235}U and ^{239}Pu isotopes and improves the uncertainty of the ^{235}U spectral shape to about 3%. The ^{235}U and ^{239}Pu antineutrino energy spectra are unfolded from the jointly deconvolved reactor spectra using the Wiener-SVD unfolding method, providing a data-based reference for other reactor antineutrino experiments and other applications. This is the first measurement of the ^{235}U and ^{239}Pu spectra based on the combination of experiments at low- and highly enriched uranium reactors.
Published: 2022
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29. [Application of electric tube stapler in laparoscopic colorectal tumor surgery].

Author: Liu WJ, Li YH, and Lin GL
Subjects: Humans, Colorectal Neoplasms surgery, Laparoscopy
Abstract: Objective: To investigate the application of electric tube stapler in laparoscopic colorectal tumor surgery. Methods: A descriptive case series study was conducted. Clinical data of patients who underwent laparoscopic colorectal surgery in Peking Union Medical College Hospital in August 2021 using domestic electric tube stapler were collected to analyze the occurrence of postoperative anastomotic leakage, anastomotic bleeding and other complications as well as postoperative intestinal function recovery. Results: A total of 11 patients with colorectal tumor were enrolled in this study, including 8 males and 3 females. Eight patients underwent laparoscopic low anterior resection (1 patient underwent protective ileostomy), and three patients underwent laparoscopic sigmoid carcinoma radical resection. During operation, power system failure of stapler occurred in 1 patient, and the replacement manual device was used to complete the anastomosis. No anastomotic leakage or bleeding occurred in the cohort of patients. There was no conversion to laparotomy or conventional anastomosis. One patient developed acute myocardial infarction 2 days after surgery. The average time to the first flatus after surgery was (2.4±0.8) days and the average length of hospital stay was (10.0±6.1) days. Conclusions: The application of electric tube stapler in laparoscopic colorectal tumor surgery has many advantages, such as safe and effective anastomosis, low morbidity of postoperative complications, and rapid recovery of intestinal function. Domestic electric tube stapler can be applied in minimally invasive surgery for colorectal tumor.
Published: 2021
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30. [Questionnaire investigation of radiation rectal injury with anxiety, depression and somatic disorder].

Author: Lian B, Cao XP, Deng HJ, Jiang J, Jiang KW, Li XX, Li YS, Lin GL, Liu JH, Bai SM, Wang F, Wang ZQ, Wu AW, Xiao Y, Yao HW, Yuan WT, Zhang W, Zhang Z, Zhou YB, Ma TH, and Zhao QC
Subjects: Aged, Anxiety, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Rectum, Surveys and Questionnaires, Depression, Quality of Life
Abstract: Objective: To observe the incidence and treatment of radiation rectal injury complicated with anxiety, depression and somatic symptom disorder. Methods: A cross-sectional survey research method was carried out. Patients with radiation rectal injury managed by members of the editorial board of Chinese Journal of Gastrointestinal Surgery were the subjects of investigation. The inclusion criteria of the survey subjects: (1) patients suffered from pelvic tumors and received pelvic radiotherapy; (2) colonoscopy showed inflammatory reaction or ulcer in the rectum. Exclusion criteria: (1) patient had a history of psycho-somatic disease before radiotherapy; (2) patient was unable to use a smart phone, unable to read and understand the questions in the questionnaire displayed on the phone; (3) patient refused to sign an informed consent form. According to the SOMA self-rating scale, PHQ-15 self-rating scale, GAD-7 and PHQ-9 self-rating scale, the electronic questionnaire of "Psychological Survey of Radiation Proctitis" was designed. The questionnaire was sent to patients with radiation rectal injury managed by the committee through the WeChat group. Observational indicators: (1) radiation rectal injury symptom assessment: using SOMA self-rating scale, radiation rectal injury symptom classification: mild group (≤3 points), moderate group (4-6 points) and severe group (> 6 points); (2) incidence of anxiety, depression and physical disorder: using GAD-7, PHQ-9 and PHQ-15 self-rating scales respectively for assessment; (3) correlation of radiation rectal injury symptom grading with anxiety, depression, and somatic symptom disorder. Results: Seventy-one qualified questionnaires were collected, of which 41 (56.9%) were from Guangzhou. Among the 71 patients, 6 were males and 65 were females; the mean age was (55.7±9.3) years old and 48 patients (67.6%) were less than 60 years old; the median confirmed duration of radiation rectal injury was 2.0 (1.0, 5.0) years. (1) Evaluation of symptoms of radiation rectal injury: 18 cases of mild (25.4%), 27 cases of moderate (38.0%), and 26 cases of severe (36.6%). (2) Incidence of anxiety, depression and somatic disorder: 12 patients (16.9%) without comorbidities; 59 patients (83.1%) with anxiety, depression, or somatic disorder, of whom 2 patients only had anxiety, 1 patient only had depression, 9 only had somatic disorder, 2 had anxiety plus depression, 4 had anxiety plus somatic disorder, 2 had depression plus somatic disorder, and 40 had all three symptoms. (3) correlation of radiation rectal injury grading with anxiety, depression, and somatic symptom disorder: as compared to patients in mild group and moderate group, those in severe group had higher severity of anxiety and somatic symptom disorder ( Z =-2.143, P =0.032; Z =-2.045, P =0.041), while there was no statistically significant difference of depression between mild group and moderate group ( Z =-1.176, P =0.240). Pearson correlation analysis revealed that radiation rectal injury symptom score was positively correlated with anxiety ( r =0.300, P =0.013), depression ( r =0.287, P =0.015) and somatic symptom disorder ( r =0.344, P =0.003). Conclusions: The incidence of anxiety, depression, and somatic symptom disorder in patients with radiation rectal injury is extremely high. It is necessary to strengthen the diagnosis and treatment of somatic symptom disorder, so as to alleviate the symptoms of patients with pelvic perineum pain and improve the quality of life.
Published: 2021
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30 results on '"Lin, G. L."'

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