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381 results on '"Liew, Danny"'

3. Sociocultural and Demographic Factors Predict Readmissions for General Surgery Patients

Author

Kovoor, Joshua G., Bacchi, Stephen, Gupta, Aashray K., Nann, Silas D., Stretton, Brandon, Chong, Esther H. L., Hewitt, Joseph N., Bhanushali, Ameya, Nathin, Kayla, Aujayeb, Nidhi, Lu, Amy, Ovenden, Christopher D., John, Athul, Reid, Jessica L., Gluck, Samuel, Liew, Danny, Reddi, Benjamin A., Hugh, Thomas J., Dobbins, Christopher, Padbury, Robert T., Hewett, Peter J., Trochsler, Markus I., and Maddern, Guy J.

Published
2023
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4. Intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis (PREDICT-UC): an open-label, multicentre, randomised controlled trial

Author

Choy, Matthew C, Li Wai Suen, Christopher F D, Con, Danny, Boyd, Kristy, Pena, Raquel, Burrell, Kathryn, Rosella, Ourania, Proud, David, Brouwer, Richard, Gorelik, Alexandra, Liew, Danny, Connell, William R, Wright, Emily K, Taylor, Kirstin M, Pudipeddi, Aviv, Sawers, Michelle, Christensen, Britt, Ng, Watson, Begun, Jakob, Radford-Smith, Graham, Garg, Mayur, Martin, Neal, van Langenberg, Daniel R, Ding, Nik S, Beswick, Lauren, Leong, Rupert W, Sparrow, Miles P, and De Cruz, Peter

Published
2024
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7. Delayed return of bowel function after general surgery in South Australia

Author

Kovoor, Joshua G., Bacchi, Stephen, Stretton, Brandon, Gupta, Aashray K., Jacobsen, Jonathan Henry W., To, Minh-Son, Goh, Rudy, Hewitt, Joseph N., Ovenden, Christopher D., Warren, Leigh, Marshall-Webb, Matthew, Jones, Karen L., Reddi, Benjamin A., Liew, Danny, Dobbins, Christopher, Padbury, Robert T., Hewett, Peter J., Hugh, Thomas J., Trochsler, Markus I., and Maddern, Guy J.

Published
2024
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8. A Nonrandomized Pilot Study to Investigate the Acceptability and Feasibility of LivR Well: A Multifaceted 28-Day Home-Based Liver Optimization Program for Acute-on-Chronic Liver Failure

Author

Ngu, Natalie L.Y., Saxby, Edward, Worland, Thomas, Anderson, Patricia, Stothers, Lisa, Hunter, Jo, Elford, Alexander T., Ha, Phil, Hartley, Imogen, Roberts, Andrew, Seah, Dean, Tambakis, George, Connoley, Declan, Figredo, Anita, Ratnam, Dilip, Liew, Danny, Rogers, Benjamin, Sievert, William, Bell, Sally, and Le, Suong

Published
2024
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31. A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trial

Author

Ngu, Natalie LY, Saxby, Edward, Worland, Thomas, Anderson, Patricia, Stothers, Lisa, Figredo, Anita, Hunter, Jo, Elford, Alexander, Ha, Phil, Hartley, Imogen, Roberts, Andrew, Seah, Dean, Tambakis, George, Liew, Danny, Rogers, Benjamin, Sievert, William, Bell, Sally, and Le, Suong

Published
2022
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40. Inappropriate prescribing and association with readmission or mortality in hospitalised older adults with frailty: a systematic review and meta-analysis.

Author

Inglis, Joshua M., Caughey, Gillian, Thynne, Tilenka, Brotherton, Kate, Liew, Danny, Mangoni, Arduino A., and Shakib, Sepehr

Subjects
EMERGENCY room visits, PATIENT readmissions, MIDDLE-aged persons, RANDOM effects model, CLINICAL trials
Abstract

Background: Inappropriate prescribing (IP) is common in hospitalised older adults with frailty. However, it is not known whether the presence of frailty confers an increased risk of mortality and readmissions from IP nor whether rectifying IP reduces this risk. This review was conducted to determine whether IP increases the risk of adverse outcomes in hospitalised middle-aged and older adults with frailty. Methods: A systematic review was conducted on IP in hospitalised middle-aged (45–64 years) and older adults (≥ 65 years) with frailty. This review considered multiple types of IP including potentially inappropriate medicines, prescribing omissions and drug interactions. Both observational and interventional studies were included. The outcomes were mortality and hospital readmissions. The databases searched included MEDLINE, CINAHL, EMBASE, World of Science, SCOPUS and the Cochrane Library. The search was updated to 12 July 2024. Meta-analysis was performed to pool risk estimates using the random effects model. Results: A total of 569 studies were identified and seven met the inclusion criteria, all focused on the older population. One of the five observational studies found an association between IP and emergency department visits and readmissions at specific time points. Three of the observational studies were amenable to meta-analysis which showed no significant association between IP and hospital readmissions (OR 1.08, 95% CI 0.90–1.31). Meta-analysis of the subgroup assessing Beers criteria medicines demonstrated that there was a 27% increase in the risk of hospital readmissions (OR 1.27, 95% CI 1.03–1.57) with this type of IP. In meta-analysis of the two interventional studies, there was a 37% reduced risk of mortality (OR 0.63, 95% CI 0.40-1.00) with interventions that reduced IP compared to usual care but no difference in hospital readmissions (OR 0.83, 95% CI 0.19–3.67). Conclusions: Interventions to reduce IP were associated with reduced risk of mortality, but not readmissions, compared to usual care in older adults with frailty. The use of Beers criteria medicines was associated with hospital readmissions in this group. However, there was limited evidence of an association between IP more broadly and mortality or hospital readmissions. Further high-quality studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Infectious and sepsis presentations to, and hospital admissions from emergency departments in Victoria, Australia.

Author

Flacks, Nathaniel, Martin, Catherine, Liew, Danny, Walker, Katie, and Jones, Daryl

Subjects
INFECTION risk factors, RISK assessment, PATIENTS, HOSPITAL admission & discharge, HOSPITAL emergency services, EMERGENCY medicine, RETROSPECTIVE studies, HOSPITAL mortality, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, SEPSIS, INTENSIVE care units, CLINICAL deterioration, NOSOLOGY, DISEASE risk factors
Abstract

Objective: To investigate the frequency and outcomes of adult infectious and sepsis presentations to, and hospital admissions from, Emergency Departments (EDs) in Victoria, Australia. Methods: Retrospective cohort study using the Victorian Emergency Minimum Dataset and Victorian Admitted Episodes Dataset. We included adults (age ≥ 18 years) presenting to an ED, or admitted to hospital from ED in Victoria between July 2017 and June 2018. One‐year mortality was analysed until June 2019 using the Victorian Death Index, and ICD‐10 coding was used to identify cases. Results: Among 1.28 million ED presentations over 1 year, 12.00% and 0.45% were coded with infectious and sepsis diagnoses, respectively. Despite having lower triage categories, patients with infections were more likely to be admitted to hospital (50.4% vs 44.9%), but not directly to ICU (0.8%). Patients coded with sepsis were assigned higher triage categories and required hospital admission much more frequently (96.4% vs 44.9%), including to ICU (15.9% vs 0.8%). Patients presenting with infections and sepsis had increased risk of 1‐year mortality (adjusted hazard ratio 1.44 and 4.13, respectively). Of the 648 280 hospital admissions from the ED, infection and sepsis were coded in 23.69% and 2.66%, respectively, and the adjusted odds ratio for 1‐year mortality were 1.64 and 4.79, respectively. Conclusions: Infections and sepsis are common causes of presentation to, and admission from the ED in Victoria. Such patients experience higher mortality than non‐infectious patients, even after adjusting for age. There is a need to identify modifiable factors contributing to these outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Societal health and economic burden of cardiovascular diseases in the population with type 2 diabetes in Qatar. A 10‐year forecasting model.

Author

Abushanab, Dina, Al‐Badriyeh, Daoud, Marquina, Clara, Liew, Danny, Al‐Zaidan, Manal, Ghaith Al‐Kuwari, Mohammed, Abdulmajeed, Jazeel, and Ademi, Zanfina

Subjects
TYPE 2 diabetes, CARDIOVASCULAR diseases, QUALITY-adjusted life years, MYOCARDIAL infarction, FORECASTING
Abstract

Aims: To predict the future health and economic burden of cardiovascular disease (CVD) in type 2 diabetes (T2D) in Qatar. Materials and Methods: A dynamic multistate model was designed to simulate the progression of fatal and non‐fatal CVD events among people with T2D in Qatar aged 40‐79 years. First CVD events [i.e. myocardial infarction (MI) and stroke] were calculated via the 2013 Pooled Cohort Equation, while recurrent CVD events were sourced from the REACH registry. Key model outcomes were fatal and non‐fatal MI and stroke, years of life lived, quality‐adjusted life years, total direct medical costs and total productivity loss costs. Utility and cost model inputs were drawn from published sources. The model adopted a Qatari societal perspective. Sensitivity analyses were performed to test the robustness of estimates. Results: Over 10 years among people with T2D, model estimates 108 195 [95% uncertainty interval (UI) 104 249‐112 172] non‐fatal MIs, 62 366 (95% UI 60 283‐65 520) non‐fatal strokes and 14 612 (95% UI 14 472‐14 744) CVD deaths. The T2D population accrued 4 786 605 (95% UI 4 743 454, 4 858 705) total years of life lived and 3 781 833 (95% UI 3 724 718‐3 830 669) total quality‐adjusted life years. Direct costs accounted for 57.85% of the total costs, with a projection of QAR41.60 billion (US$11.40 billion) [95% UI 7.53‐147.40 billion (US$2.06‐40.38 billion)], while the total indirect costs were expected to exceed QAR30.31 billion (US$8.30 billion) [95% UI 1.07‐162.60 billion (US$292.05 million‐44.55 billion)]. Conclusions: The findings suggest a significant economic and health burden of CVD among people with T2D in Qatar and highlight the need for more enhanced preventive strategies targeting this population group. [ABSTRACT FROM AUTHOR]

Published
2024
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