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Your search keyword '"Liang, Yuelong"' showing total 19 results
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19 results on '"Liang, Yuelong"'

5. An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut.

Author

Nan, Kewang, Wong, Kiwan, Li, Dengfeng, Ying, Binbin, McRae, James C., Feig, Vivian R., Wang, Shubing, Du, Ningjie, Liang, Yuelong, Mao, Qijiang, Zhou, Enjie, Chen, Yonglin, Sang, Lei, Yao, Kuanming, Zhou, Jingkun, Li, Jian, Jenkins, Joshua, Ishida, Keiko, Kuosmanen, Johannes, and Mohammed Madani, Wiam Abdalla

Subjects
ELECTRONIC equipment, ELECTRIC stimulation, COUPLINGS (Gearing), GHRELIN, CLINICAL medicine
Abstract

Ingestible electronics have the capacity to transform our ability to effectively diagnose and potentially treat a broad set of conditions. Current applications could be significantly enhanced by addressing poor electrode-tissue contact, lack of navigation, short dwell time, and limited battery life. Here we report the development of an ingestible, battery-free, and tissue-adhering robotic interface (IngRI) for non-invasive and chronic electrostimulation of the gut, which addresses challenges associated with contact, navigation, retention, and powering (C-N-R-P) faced by existing ingestibles. We show that near-field inductive coupling operating near 13.56 MHz was sufficient to power and modulate the IngRI to deliver therapeutically relevant electrostimulation, which can be further enhanced by a bio-inspired, hydrogel-enabled adhesive interface. In swine models, we demonstrated the electrical interaction of IngRI with the gastric mucosa by recording conductive signaling from the subcutaneous space. We further observed changes in plasma ghrelin levels, the "hunger hormone," while IngRI was activated in vivo, demonstrating its clinical potential in regulating appetite and treating other endocrine conditions. The results of this study suggest that concepts inspired by soft and wireless skin-interfacing electronic devices can be applied to ingestible electronics with potential clinical applications for evaluating and treating gastrointestinal conditions. Existing ingestible electronics suffer from poor tissue contact, short dwell time, and limited battery life. Here, the authors report an ingestible, battery- free, and tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Global Trends in Research of Antimicrobial Peptides for the Treatment of Drug-Resistant Bacteria from 1995 to 2021: A Bibliometric Analysis

Author

Liang,Yuelong, Huang,Zhengze, Shen,Xuqiu, Zhang,Yiyin, Chai,Yihan, Jiang,Kexin, Chen,Qi, Zhao,Feng, Liang,Yuelong, Huang,Zhengze, Shen,Xuqiu, Zhang,Yiyin, Chai,Yihan, Jiang,Kexin, Chen,Qi, and Zhao,Feng

Abstract

Yuelong Liang,1,* Zhengze Huang,1,* Xuqiu Shen,1,* Yiyin Zhang,1 Yihan Chai,1 Kexin Jiang,1 Qi Chen,2 Feng Zhao3 1Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China; 2Department of General Surgery, Hangzhou Fuyang Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuelong Liang; Feng Zhao, Email yuelongliang@zju.edu.cn; fengzhao3901@zju.edu.cnBackground: Antimicrobial peptides (AMPs) can act on the bacterial cell membrane to play an antibacterial role in types of drug-resistant bacteria. Therefore, AMPs have attracted more and more attention in the treatment of drug-resistant bacteria.Methods: Bibliometric analysis was employed to sort out the development and trends in the research of AMPs in the treatment of drug-resistant bacteria and map the knowledge structure for scholars.Results: Since 2010, the publications and citations in this field have exploded, indicating a growing global interest in the field of AMPs for the treatment of drug-resistant bacteria. And as major countries in this field, China and the USA had conducted very in-depth exchanges and cooperation, which had injected a steady stream of impetus into this field. Both old and new scholars have made efforts, and related fields have developed rapidly, especially in the synthesis and improvement of novel AMPs. In recent years, research directions in the field of AMPs for the treatment of drug-resistant bacteria gradually focused on the practical application, optimization of drug delivery mode, optimization of synthesis mode, screening of new AMPs and other fields, indicating that the relevant research results of AMPs for the

Published
2023

18. Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic Analysis

Author

Zhang, Yiyin, primary, Mao, Qijiang, additional, Li, Yirun, additional, Cheng, Jiaxi, additional, Xia, Qiming, additional, Chen, Guoqiao, additional, Chen, Peng, additional, Jin, Shengxi, additional, Li, Duguang, additional, Zhong, Cheng, additional, Yang, Jing, additional, Fan, Xiaoxiao, additional, Liang, Yuelong, additional, and Lin, Hui, additional

Published
2022
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19. GelNB molecular coating as a biophysical barrier to isolate intestinal irritating metabolites and regulate intestinal microbial homeostasis in the treatment of inflammatory bowel disease

Author

Mao, Qijiang, Pan, Haoqi, Zhang, Yiyin, Zhang, Yi, Zhu, Qiuwen, Hong, Yi, Huang, Zhengze, Li, Yang, Feng, Xu, Fang, Yifeng, Chen, WenChao, Chen, Pengfei, Shen, Bo, Ouyang, Hongwei, and Liang, Yuelong

Abstract

Inflammatory bowel disease (IBD) is a chronic, immune-mediated inflammatory disease characterized by the destruction of the structure and function of the intestinal epithelial barrier. Due to the poor remission effect and severe adverse events associated with current clinical medications, IBD remains an incurable disease. Here, we demonstrated a novel treatment strategy with high safety and effective inflammation remission via tissue-adhesive molecular coating. The molecular coating is composed of o-nitrobenzaldehyde (NB)-modified Gelatin (GelNB), which can strongly bond with –NH2on the intestinal surface of tissue to form a thin biophysical barrier. We found that this molecular coating was able to stay on the surface of the intestine for long periods of time, effectively protecting the damaged intestinal epithelium from irritations of external intestinal metabolites and harmful flora. In addition, our results showed that this coating not only provided a beneficial environment for cell migration and proliferation to promote intestinal repair and regeneration, but also achieved a better outcome of IBD by reducing intestinal inflammation. Moreover, the in vivoexperiments showed that the GelNB was better than the classic clinical medication—mesalazine. Therefore, our molecular coating showed potential as a promising strategy for the prevention and treatment of IBD.

Published
2022
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