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Your search keyword '"Li, Wen-Peng"' showing total 7 results
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7 results on '"Li, Wen-Peng"'

6. Special type of distal junctional failure exhibits pelvic incidence changes: sacroiliac joint-related pain following lumbar spine surgery

Author

Yan, Hao-Lin, Jiang, Xu, Zhang, Chi, Yang, Can-Chun, Wu, Jiong-Lin, Guo, Rui, Peng, Xiao-Shuai, Wang, Zhe-Yu, Zhang, Di, Zhao, Qian-Cheng, Zeng, Zi-Liang, Li, Wen-Peng, Huang, Ren-Yuan, Zhang, Zhi-Lei, Wang, Qi-Wei, Jin, Song, Hu, Xu-Min, and Gao, Liang-Bin

Subjects
Original Article, General Medicine
Abstract

BACKGROUND: Currently, change in pelvic incidence (PI) in patients after spinal surgery have not been associated with clear clinical symptoms. This study sought to compare changes in the sagittal parameters of different patients before and after thoracolumbar spine surgery, the relationship between PI change and sacroiliac joint pain (SIJP) after surgery was clarified, and the correlation between PI change and sacroiliac joint (SIJ) activity was verified. METHODS: This study retrospectively analyzed the data of patients who underwent thoracolumbar fusion at Sun Yat-sen Memorial Hospital from January 2019 to June 2021. The spinal and pelvic parameters [including pelvic tilt (PT), sacral slope (SS), PI, lumbar lordosis (LL) angle, etc.] of 409 patients with standard standing lateral radiographs before and after surgery were compared and analyzed. Postoperative follow-up of all patients with standardized SIJP assessment. The incidence of postoperative SIJP, and its correlation with sagittal parameters of the spine and pelvis, surgical methods, and the basic characteristics of patients were analyzed. The Chi-square test was used for categorical variables, the independent-sample t-test was used for generally conformed normally distributed continuous variables. Risk factors associated with the development of SIJP were analyzed using logistics regression. Correlations among SS, PI, and the 4 other sagittal parameters were analyzed using the Pearson correlation coefficient (r). RESULTS: Postoperative PI changes tended to be larger in the lowest instrumented vertebra (LIV) (L4 and above: 1.63°; L5: 2.43°; S1: 3.83°; P4° [odds ratio (OR) =13.051; P4°) are similar to the mechanism of distal junctional kyphosis (DJK), while such changes make patients prone to SIJP following lumbar spine surgery.

Published
2022

7. Neuroprotective effects of all-trans-retinoic acid are mediated via downregulation of TLR4/NF-κB signaling in a rat model of middle cerebral artery occlusion.

Author

Tan L, Liu Q, Chen S, You R, Li X, Wen T, and Peng Z

Subjects
Animals, Male, Rats, Disease Models, Animal, Microglia drug effects, Microglia metabolism, Toll-Like Receptor 4 metabolism, Toll-Like Receptor 4 drug effects, Rats, Sprague-Dawley, Tretinoin pharmacology, Tretinoin therapeutic use, Infarction, Middle Cerebral Artery drug therapy, Neuroprotective Agents pharmacology, Neuroprotective Agents therapeutic use, Signal Transduction drug effects, NF-kappa B metabolism, NF-kappa B drug effects, Down-Regulation drug effects
Abstract

Objectives: To determine the effects of all-trans-retinoic acid (ATRA) on the post-stroke inflammatory response and elucidate the underlying molecular mechanisms., Methods: This animal experiment was conducted at Central Laboratory, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China during 2020-2022. Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 1.5 h, and treated with ATRA at 2 and 24 h after reperfusion. Neurological deficit scores on behavioral tests, and cerebral infarct volume, microglial polarization, and the expression levels of inflammatory cytokines and proteins associated with TLR4/NF-κB signaling were assessed., Results: The ATRA administration reduced cerebral infarct volume and ameliorated neurological deficit scores in MCAO rats. Additionally, ATRA relieved cerebral edema and downregulated the secretion of proinflammatory cytokines after stroke. Finally, ATRA attenuated the polarization of the microglia toward the M1 phenotype and promoted the activation of the beneficial M2 phenotype; the underlying mechanism potentially involved the suppression of the TLR4/NF-κB signaling pathway., Conclusion: The ATRA treatment promoted functional recovery in an experimental model of ischemic stroke by attenuating neural inflammation. ATRA potentially modulated microglia-mediated neuroinflammation via the downregulation of the TLR4/NF-κB signaling pathway, which makes it a candidate treatment for post-stroke neuroinflammation., (Copyright: © Neurosciences.)

Published
2024
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